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Journal of Laboratory Physicians

Ruchita Tyagi, Arshdeep Kaur, Pavneet Kaur Selhi, Harpreet Kaur Puri, Neena Sood
Histoplasma capsulatum is no longer confined to certain geographic areas and should always be considered in the differential diagnosis of lymphadenopathy and organomegaly in HIV-positive patients. We present an unusual case of a 20-year-old immunocompromised male of African origin presenting with fever, jaundice, hepatosplenomegaly, and retroperitoneal and cervical lymphadenopathy. Fine needle aspiration (FNA) smears from the cervical lymph node revealed numerous yeast forms of histoplasma in macrophages. The patient succumbed to the fulminant infection...
July 2016: Journal of Laboratory Physicians
Navjot Kaur, Bal Chander, Harjit Kaur, Rashmi Kaul
Heterotopic pancreatic tissue in the gall bladder is an uncommon incidental finding in most cases. We hereby describe the case of a 45-year-old woman who presented with symptoms of acalculous cholecystitis. Pathological examination detected heterotopic pancreatic tissue, pseudopyloric metaplasia, and adenomyomatous hyperplasia in the gall bladder. This is a rare combination of three entities which is being reported for the first time. This case emphasizes that heterotopic pancreas might be the causative factor for cholecystitis...
July 2016: Journal of Laboratory Physicians
Biswajit Dey, Bhawana Badhe, Krishna Kumar Govindarajan, Ranjith Arumbakkam Ramesh
Xp11.2 translocation renal cell carcinomas (TRCCs) are a group of neoplasms with distinct clinical, histopathological appearance, immunohistochemical, and cytogenetic profile. We report a case of Xp11.2 translocation TRCC in an 11-year-old male diagnosed based on immunohistochemistry and fluorescence in situ hybridization.
July 2016: Journal of Laboratory Physicians
Jai Bhagwan Sharma
Female genital tuberculosis (FGTB) is an important cause of infertility in developing countries. Various type of TB salpingitis can be endosalpingitis, exosalpingitis, interstitial TB salpingitis, and salpingitis isthmica nodosa. The fallopian tubes are thickened enlarged and tortuous. Unilateral or bilateral hydrosalpinx or pyosalpinx may be formed. A new sign python sign is presented in which fallopian tube looks like a blue python on dye testing in FGTB.
July 2016: Journal of Laboratory Physicians
Sunitha S Kiran, Saraswathy Aithal, Charalingappa S Belagavi
Hemoglobin E (HbE) is estimated to affect at least one million people around the world. Carrier frequency of hemoglobin E/β-thalassemia (HbE/β-thalassemia) is highest in Southeast Asia, reaching as high as 60% in parts of Thailand, Laos, and Cambodia. In the Indian subcontinent, highest frequency is observed in The Northeast regions, but relatively rare in rest of the country. Increasing migration of population from highly affected areas is resulting in rising prevalence in The South and other parts of India...
July 2016: Journal of Laboratory Physicians
Prathiksha Pai, Meena N Jadhav, Rashmi K Patil, Shreekant K Kittur
Sertoliform endometrioid carcinoma of the ovary (SEC) is an uncommon variant that bears histologic similarity to sertoli and sertoli-leydig cell tumors. We report an interesting case of SEC in a 55-year-old female with a left ovarian mass with torsion. Histology revealed an SEC, featuring foci of typical endometrioid carcinoma, and areas composed of uniform, small, hollow tubules lined by columnar cells with apical cytoplasm. Tumor cells were strongly immunoreactive for EMA and cytokeratin but negative for inhibin; thus, confirming the diagnosis of SEC ovary...
July 2016: Journal of Laboratory Physicians
Archana Srinivasyaiah, Priyanka Nitin, Usha Hegde
BACKGROUND: In routine histopathology, decalcification of teeth is an essential and important step during tissue processing. The present study was attempted to decalcify teeth using microwave method and to compare it with conventional decalcification method. AIM: To compare microwave decalcification with conventional decalcification method with respect to the speed of decalcification, preservation of tissue structure, and efficacy of staining. MATERIALS AND METHODS: A total of 72 single-rooted premolars were used for both conventional and microwave decalcification methods...
July 2016: Journal of Laboratory Physicians
Suheyla Gorar, Bulent Alioglu, Esranur Ademoglu, Seyit Uyar, Handan Bekdemir, Zehra Candan, Beylan Saglam, Gonul Koc, Cavit Culha, Yalcin Aral
CONTEXT: Impact of gestational diabetes mellitus (GDM) on the coagulation system, dynamics involved at a pathophysiological level and the exact mechanism remain unclear. AIMS: To evaluate the association between diabetes-related parameters and hemostatic factors to search for a tendency of thrombosis in GDM. SETTINGS AND DESIGN: Nineteen pregnant women who had GDM, 16 healthy pregnant and 13 healthy nonpregnant controls admitted to the Endocrinology outpatient clinics were enrolled in the study...
July 2016: Journal of Laboratory Physicians
Ramandeep Kaur, Neerja Jindal, Shilpa Arora, Shajla Kataria
BACKGROUND: Xpert MTB/RIF assay has revolutionized the diagnosis of tuberculosis (TB) by simultaneously detecting the bacteria and resistance to rifampicin (RIF), a surrogate marker for multidrug-resistant TB (MDR-TB) in <2 h. The RIF resistance pattern in Malwa region of Punjab, India, is not documented. Here, we report the epidemiology of RIF-resistant TB and mutations in rpoB gene of Mycobacterium tuberculosis (MTB). MATERIALS AND METHODS: A total of 1612 specimens received between October 2013 and February 2015 were tested by Xpert MTB/RIF assay following manufacturer's instructions...
July 2016: Journal of Laboratory Physicians
Devki Nandan, Prachi Kansal, Neha Patharia, Parul Goyal
PURPOSE: The objective of this study is to measure levels of nitrites in induced sputum in children with asthma and correlate it with clinical asthma parameters. METHOD: This prospective observational study was done in PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi, on 91 children aged 7-18 years with mild and moderate persistent asthma. Patients were specifically evaluated for five clinical parameters of asthma (i.e. Days of acute exacerbations, use of salbutamol as rescue medication, emergency visits, nights with cough, days of school absence) and induced sputum nitrite levels was done at the time of enrollment and 3 months after treatment with inhaled budesonide...
July 2016: Journal of Laboratory Physicians
Lata Baswanna Galate, Sachee R Agrawal, Jayanthi S Shastri, Vikram Londhey
BACKGROUND: Chikungunya fever (CHIK) is an arboviral disease. Dengue fever (DENG) and CHIK are indistinguishable clinically and need to be differentiated by laboratory investigations. PURPOSE: This study aimed at estimating the seroprevalence of CHIK mono-infection and CHIK and DENG dual infection in suspected patients. We also analyzed the age, sex distribution, joint involvement, and relation of joint movement restriction with visual analog scale (VAS). MATERIALS AND METHODS: Two hundred patients clinically suspected with DENG and CHIK were enrolled from a Tertiary Care Hospital in Mumbai from April 2012 to October 2013...
July 2016: Journal of Laboratory Physicians
Sanjiv Kumar Bansal, Sarita Agarwal, Mridul Kumar Daga
INTRODUCTION: The high prevalence, severity, and prematurity of coronary artery disease (CAD) in the Indian population cannot be completely explained by the conventional lipid parameters and the existing lipid indices. AIMS AND OBJECTIVES: To calculate newly defined advanced atherogenic index (AAI) in premature CAD patients and compare it between cases and controls and Correlate its values with the existing indices. MATERIAL AND METHODS: One hundred and twenty premature CAD patients and an equal number of age and sex matched healthy individuals were included in this study...
July 2016: Journal of Laboratory Physicians
Altaf Ahmad Mir, Bela Goyal, Sudip Kumar Datta, Saidaiah Ikkurthi, Arnab Pal
INTRODUCTION: Free ionic calcium is the metabolically active component of total calcium (TCa) in blood. However, most laboratories report TCa levels that are dependent on serum albumin concentration. Hence, several formulae have evolved to calculate free calcium levels from TCa after adjustment for albumin. However, free calcium can directly be measured using direction selective electrodes rather than spectrophotometric methods used in autoanalyzers. OBJECTIVES: This study compares the levels of free calcium obtained by measurement by direct ion selective electrode (ISE) and the one calculated as a function of TCa by formulae...
July 2016: Journal of Laboratory Physicians
Manoj Madakshira Gopal, Ajay Malik
No abstract text is available yet for this article.
January 2016: Journal of Laboratory Physicians
Preeti Chavan, Vivek Bhat, Manikchandra Tiwari, Umakant Gavhane, Sanjay Kumar Pal
No abstract text is available yet for this article.
January 2016: Journal of Laboratory Physicians
Mohammad Jaseem Hassan, Safia Rana, Sabina Khan, Zeeba Shamim Jairajpuri, Seema Monga, Abhinav Jain, Sujata Jetley
The thyroglossal duct cysts (TGDCs) are the most common congenital anomaly of the thyroid, usually manifested as painless midline neck mass. Malignancy is very rare and is reported in around 1% of cases as an incidental finding after histopathological evaluation of resected cyst. Papillary carcinoma is the most common carcinoma reported in TGDC. Here, we report a case of 17-year-old-female, who presented with a gradually increasing midline neck mass which moves with swallowing. On imaging a diagnosis of infected TGDC was made...
January 2016: Journal of Laboratory Physicians
Jitendra Nasit, Viren Vaghsiya, Srilaxmi Hiryur, Smita Patel
Subependymal giant cell astrocytoma (SEGA) is a low grade (WHO Grade I) tumor, usually seen in patients with tuberous sclerosis complex and commonly occurs at a lateral ventricular location. Intraoperative squash cytologic features can help in differentiating SEGA from gemistocytic astrocytoma (GA), giant cell glioblastoma and ependymoma, in proper clinical context and radiological findings, which may alter the surgical management. Here, we present a case of SEGA with squash cytologic findings and a review of cytology findings of SEGA presently available in the literature...
January 2016: Journal of Laboratory Physicians
Srirangaraj Sreenivasan, Arunava Kali, Jothimani Pradeep
Shigella enteritis remains an important cause of mortality and morbidity in all age groups, in developing as well as developed countries. Owing to the emerging resistance to multiple antibiotics among Shigella spp., it has been recognized as a major global public health concern and warrants constant monitoring of its resistance pattern. We report a case of segmental ileitis caused by non.-ESBL producing multidrug resistant Shigella flexneri in an infant clinically mimicking intussusception, which was effectively treated by ceftriaxone...
January 2016: Journal of Laboratory Physicians
Varun Goel, Dinesh Kumar, Rajendra Kumar, Purva Mathur, Sarman Singh
BACKGROUND: Urinary tract infections (UTIs) remain a major problem both in hospitalized and outdoor patients. Multidrug-resistant enterococci are emerging as a major nosocomial pathogen with increasing frequency. However, the incidence of community-acquired enterococcal infections and species prevalent in India is not thoroughly investigated. OBJECTIVES: This study aims to estimate the burden of community-acquired UTIs seen at a tertiary care hospital and to identify the Enterococcus species isolated from these patients...
January 2016: Journal of Laboratory Physicians
Trupti B Naik, Shobha D Nadagir, Asmabegaum Biradar
CONTEXT: Group A beta-hemolytic streptococci (GAS) is the most frequently isolated pathogen in acute pharyngitis. However, the role of Group C (GCS) and Group G (GGS) streptococci in disease burden is under recognized. The present study is carried out to find out the prevalence of acute pharyngitis caused by the different serogroups of streptococci and antibiotic susceptibility pattern of these streptococcal isolates. STUDY AND DESIGN: A cross sectional study. MATERIALS AND METHODS: A total of 218 throat swabs from patients with acute pharyngitis and 82 from healthy controls were collected and processed as per standard protocol...
January 2016: Journal of Laboratory Physicians
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