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Journal of Biomedical Research

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https://www.readbyqxmd.com/read/29988026/luminal-extracellular-domains-of-chimeric-ci-m6pr-c-proteins-interfere-with-their-retrograde-endosome-to-tgn-trafficking-in-the-transient-expression-system
#1
Fei Chang, Na Li, Kang Yan, Yumin Huang, Hongfei Xu, Yongjian Liu
The membrane trafficking of cation-independent mannose 6-phosphate receptor (CI-M6PR) between the trans-Golgi network (TGN) and endosomal compartments is not only critical for maintaining lysosomal function but also a well-known event for understanding molecular and cellular mechanisms in retrograde endosome-to-TGN trafficking. Although it has been well established in literature that the C-terminus of bovine CI-M6PR determines its retrograde trafficking, it remains unclear whether the luminal domain of the protein plays a role on these sorting events...
July 10, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29970623/emerging-pathways-of-communication-between-the-heart-and-non-cardiac-organs
#2
Hardy-Rando Eugenio, Fernandez-Patron Carlos
The breakthrough discovery of cardiac natriuretic peptides provided the first direct demonstration of the connection between the heart and the kidneys for the maintenance of sodium and volume homeostasis in health and disease. Yet, little is still known about how the heart and other organs cross-talk. Here, we review three physiological mechanisms of communication linking the heart to other organs through: i) cardiac natriuretic peptides, ii) the microRNA-208a/mediator complex subunit-13 axis and iii) the matrix metalloproteinase-2 (MMP-2)/C-C motif chemokine ligand-7/cardiac secreted phospholipase A2 (sPLA2) axis - a pathway which likely applies to the many cytokines, which are cleaved and regulated by MMP-2...
July 2, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29970622/psychotic-due-to-bath-salts-and-methamphetamines-emergency-cesarean-section-under-general-anesthesia
#3
Schloemerkemper Nina
The use of "bath salts" or other new psychoactive substances, otherwise known as "legal highs", is increasing. Illicit drug use during pregnancy is not uncommon. Nevertheless, literature reporting bath salts and their effect on pregnancy is scant. Besides, there seems to be no literature about bath salts and conduct of general anesthesia. This case report describes a general anesthetic for the surgical delivery of an infant to a woman under the acute influence of bath salts and methamphetamines...
July 2, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29884775/a-novel-extradural-nerve-transfer-technique-by-coaptation-of-c4-to-c5-and-c7-to-c6-for-treating-isolated-upper-trunk-avulsion-of-the-brachial-plexus
#4
Kai-Xiang Yang, Shao-Hua Zhang, Da-Wei Ge, Tao Sui, Hong-Tao Chen, Xiao-Jian Cao
The study aimed to demonstrate the feasibility of an extradural nerve anastomosis technique for the restoration of a C5 and C6 avulsion of the brachial plexus. Nine fresh frozen human cadavers were used. The diameters, sizes, and locations of the extradural spinal nerve roots were observed. The lengths of the extradural spinal nerve roots and the distance between the neighboring nerve root outlets were measured and compared in the cervical segments. In the spinal canal, the ventral and dorsal roots were separated by the dura and arachnoid...
June 8, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29921747/diagnostic-performance-of-contrast-enhanced-ultrasound-and-enhanced-magnetic-resonance-for-breast-nodules
#5
Cui-Ying Li, Hai-Yan Gong, Li-Jun Ling, Li-Wen Du, Tong Su, Shui Wang, Jie Wang
In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound (US), contrast-enhanced US (CEUS), combined US and CEUS and magnetic resonance imaging (MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve...
June 1, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29752428/angiopoietin-like-protein-3-angptl3-deficiency-and-familial-combined-hypolipidemia
#6
Patrizia Tarugi, Stefano Bertolini, Sebastiano Calandra
Three members of the angiopoietin-like (ANGPTL) protein family-ANGPTL3, ANGPTL4 and ANGPTL8- are important regulators of plasma lipoproteins. They inhibit the enzyme lipoprotein lipase, which plays a key role in the intravascular lipolysis of triglycerides present in some lipoprotein classes. This review focuses on the role of ANGPTL3 as emerged from the study of genetic variants of Angptl3 gene in mice and humans. Both loss of function genetic variants and inactivation of Angptl3 gene in mice are associated with a marked reduction of plasma levels of triglyceride and cholesterol and an increased activity of lipoprotein lipase and endothelial lipase...
April 12, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29921746/legal-protection-of-the-rights-of-clinical-trial-subjects-in-china
#7
Yuan-Peng Ren, Xin-Rui Jin, Shan Jiang, Bai-Sheng Jiang
No abstract text is available yet for this article.
March 26, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29336355/evaluation-of-cardiolipin-nanodisks-as-lipid-replacement-therapy-for-barth-syndrome
#8
Nikita Ikon, Fong-Fu Hsu, Jennifer Shearer, Trudy M Forte, Robert O Ryan
Barth syndrome (BTHS) is a mitochondrial disorder characterized by cardiomyopathy and skeletal muscle weakness. Disease results from mutations in the tafazzin (TAZ) gene, encoding a phospholipid transacylase. Defective tafazzin activity results in an aberrant cardiolipin (CL) profile. The feasibility of restoring the intracellular CL profile was tested by in vivo administration of exogenous CL in nanodisk (ND) delivery particles. Ninety mg/kg CL (as ND) was administered to doxycycline-inducible taz shRNA knockdown (KD) mice once a week...
March 26, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29353820/cervical-spine-fractures-in-osteopetrosis-a-case-report-and-review-of-the-literature
#9
Arjang Ahmadpour, Amir Goodarzi, Darrin J Lee, Ripul R Panchal, Kee D Kim
While management of appendicular fractures has been well described in the setting of osteopetrosis, there is limited information on managing fractures of the axial spine. Here we present an osteopetrotic patient with multiple traumatic multiple, comminuted, unstable cervical spinal fractures managed with non-operative stabilization, and provide a review of the pathophysiology, genetic characteristics, and special considerations that must be explored when determining operative versus non-operative management of spinal injury in osteopetrosis...
January 18, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29353819/interference-with-the-c-terminal-structure-of-marf1-causes-defective-oocyte-meiotic-division-and-female-infertility-in-mice
#10
Guang-Yi Cao, Ming-Zhe Li, Hao Wang, Lan-Ying Shi, You-Qiang Su
Meiosis-arrest female 1 (MARF1) is a recently identified key oogenic regulator essential for the maintenance of female fertility and genome integrity in mice. However, the detailed functions and the underlying mechanisms of MARF1 remain elusive. Here, in an attempt to create a mouse model expressing fluorescent protein-tagged MARF1 to facilitate further exploration of the roles of MARF1 in oocytes, we produced a Marf1-eGFP knockin (KI) mouse line in which the C-terminal structure and function of MARF1 were interfered by its fusing eGFP peptide...
January 18, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29353818/safety-of-axitinib-and-sorafenib-monotherapy-for-patients-with-renal-cell-carcinoma-a-meta-analysis
#11
Fei Qin, Hao Yu, Chang-Rong Xu, Hui-Hui Chen, Jian-Ling Bai
We sought to investigate safety of axitinib or sorafenib in renal cell carcinoma (RCC) patients and compare toxicity of these two vascular endothelial growth factor receptor inhibitors. Databases of PubMed and Embase were searched. We included phase II and III prospective trials, as well as retrospective studies, in which patients diagnosed with RCC were treated with axitinib or sorafenib monotherapy at a starting dose of 5 mg and 400 mg twice daily, respectively. The overall incidence of high grade hypertension, fatigue, gastrointestinal toxicity and hand-foot syndrome, along with their 95% confidence intervals (CI), were calculated using fixed- or random- effects model according to heterogeneity test results...
January 18, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29353817/transforming-growth-factor-%C3%AE-signaling-in-systemic-sclerosis
#12
Nolan B Ayers, Chen-Ming Sun, Shi-You Chen
Systemic sclerosis (SSc) is a complex, multiorgan autoimmune disease of unknown etiology. Manifestation of the disease results from an interaction of three key pathologic features including irregularities of the antigen-specific immune system and the non-specific immune system, resulting in autoantibody production, vascular endothelial activation of small blood vessels, and tissue fibrosis as a result of fibroblast dysfunction. Given the heterogeneity of clinical presentation of the disease, a lack of universal models has impeded adequate testing of potential therapies for SSc...
January 18, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29353816/human-parvovirus-b19-associated-hematopathy-in-hiv-disease-need-for-clinicopathological-revisit
#13
Idris Abdullahi Nasir, Jessy Thomas Medugu, Amos Dangana
No abstract text is available yet for this article.
January 18, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29109330/vanishing-cerebral-vasculitis-in-a-patient-with-lewy-pathology
#14
Natalia Liapounova, Kamran H Azar, J Max Findlay, Jian-Qiang Lu
Immune-mediated mechanisms are involved in the pathogenesis of both cerebral vasculitis and Parkinson's disease (PD, brainstem-predominant Lewy pathology), but the presentation of cerebral vasculitis with comorbid Lewy pathology has not yet been reported. Here we present a case of pathologically confirmed vasculitis in a 73-year-old male patient whose postmortem examination revealed Lewy pathology diagnostic of PD. This case study suggests a comorbidity of cerebral vasculitis and Lewy pathology, as well as potential pathogenic interactions between these two disorders with immune-mediated mechanisms...
November 7, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29109328/semi-automated-carotid-lumen-segmentation-in-computed-tomography-angiography-images
#15
Hamid Reza Hemmati, Mahdi Alizadeh, Alireza Kamali-Asl, Shapour Shirani
Carotid artery stenosis causes narrowing of carotid lumens and may lead to brain infarction. The purpose of this study was to develop a semi-automated method of segmenting vessel walls, surrounding tissues, and more importantly, the carotid artery lumen by contrast computed tomography angiography (CTA) images and to define the severity of stenosis and present a three-dimensional model of the carotid for visual inspection. In vivo contrast CTA images of 14 patients (7 normal subjects and 7 patients undergoing endarterectomy) were analyzed using a multi-step segmentation algorithm...
November 5, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29109329/role-of-apolipoproteins-abca1-and-lcat-in-the-biogenesis-of-normal-and-aberrant-high-density-lipoproteins
#16
Vassilis I Zannis, Shi Su, Panagiotis Fotakis
In this review, we focus on the pathway of biogenesis of HDL, the essential role of apoA-I, ATP binding cassette transporter A1 (ABCA1), and lecithin: cholesterol acyltransferase (LCAT) in the formation of plasma HDL; the generation of aberrant forms of HDL containing mutant apoA-I forms and the role of apoA-IV and apoE in the formation of distinct HDL subpopulations. The biogenesis of HDL requires functional interactions of the ABCA1 with apoA-I (and to a lesser extent with apoE and apoA-IV) and subsequent interactions of the nascent HDL species thus formed with LCAT...
November 4, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29784899/pathway-based-analysis-of-genome-wide-association-study-of-circadian-phenotypes
#17
Di-di Zhu, Jia-Min Yuan, Rui Zhu, Yao Wang, Zhi-Yong Qian, Jian-Gang Zou
Sleepiness affects normal social life, which attracts more and more attention. Circadian phenotypes contribute to obvious individual differences in susceptibility to sleepiness. We aimed to identify candidate single nucleotide polymorphisms (SNPs) which may cause circadian phenotypes, elucidate the potential mechanisms, and generate corresponding SNP-gene-pathways. A genome-wide association studies (GWAS) dataset of circadian phenotypes was utilized in the study. Then, the Identify Candidate Causal SNPs and Pathways analysis was employed to the GWAS dataset after quality control filters...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29784898/pretreatment-with-simvastatin-upregulates-expression-of-bk-2r-and-cd11b-in-the-ischemic-penumbra-of-rats
#18
Jian-Ying Zhang, Qing-Ke Bai, Ying-Dong Zhang
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductases, collectively known as statins, have been shown to minimize cerebral ischemic events in patients. We assessed the mechanisms of simvastatin pretreatment in preventing cerebral ischemia/reperfusion injury in rats using a model of middle cerebral artery occlusion (MCAO). Rats were pretreated with simvastatin 14 days prior to MCAO induction. At 3, 24, and 48 hours after reperfusion, bradykinin levels in the ischemic penumbra were assayed by ELISA, mRNA levels of bradykinin B2 receptors (BK-2Rs) and CD11b were measured by fluorescent quantitative real-time PCR (RT-PCR), and co-expression of microglia and BK-2Rs was determined by immunofluorescence...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29770779/effect-of-neoadjuvant-chemotherapy-on-the-expression-of-hormone-receptors-and-ki-67-in-chinese-breast-cancer-patients-a-retrospective-study-of-525-patients
#19
Yu-Tuan Wu, Xin Li, Lin-Jie Lu, Lu Gan, Wei Dai, Yan-Ling Shi, Vishnu Prasad Adhikari, Kai-Nan Wu, Ling-Quan Kong
This study was designed to investigate the effect of neoadjuvant chemotherapy on the expression of hormone receptors and ki67 in Chinese female breast cancer patients. The expression of estrogen receptor (ER), progesterone receptor (PR) and Ki67 among 525 neoadjuvant chemotherapy cases was studied by immunohistochemistry (IHC). Differences between specimens made through preoperative core needle biopsy (CB) and excised tissue biopsy (EB) were observed. The positive rates of ER, PR and Ki67 in CB and EB were 65...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29770778/apolipoprotein-e-in-diet-induced-obesity-a-paradigm-shift-from-conventional-perception
#20
Kyriakos E Kypreos, Eleni A Karavia, Caterina Constantinou, Aikaterini Hatziri, Christina Kalogeropoulou, Eva Xepapadaki, Evangelia Zvintzou
Apolipoprotein E (APOE) is a major protein component of peripheral and brain lipoprotein transport systems. APOE in peripheral circulation does not cross blood brain barrier or blood cerebrospinal fluid barrier. As a result, peripheral APOE expression does not affect brain APOE levels and vice versa. Numerous epidemiological studies suggest a key role of peripherally expressed APOE in the development and progression of coronary heart disease while brain APOE has been associated with dementia and Alzheimer's disease...
November 1, 2017: Journal of Biomedical Research
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