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Journal of Biomedical Research

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https://www.readbyqxmd.com/read/30190448/prostate-cancer-tends-to-metastasize-in-the-bone-mimicking-microenvironment-via-activating-nf-%C3%AE%C2%BAb-signaling
#1
Haibo Tong, Chunlin Zou, Siyuan Qin, Jie Meng, Evan T Keller, Jian Zhang, Yi Lu
Prostate cancer preferentially metastasizes to the bone. However, the underlying molecular mechanisms are still unclear. To explore the effects of a bone-mimicking microenvironment on PC3 prostate cancer cell growth and metastasis, we used osteoblast differentiation medium (ODM; minimal essential medium alpha supplemented with L-ascorbic acid) to mimic the bone microenvironment. PC3 cells grown in ODM underwent epithelial-mesenchymal transition and showed enhanced colony formation, migration, and invasion abilities compared to the cells grown in normal medium...
September 6, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30190447/association-between-pri-mir-34b-c-rs4938723-polymorphism-and-bladder-cancer-risk
#2
Mohammad Hashemi, Vahed Hasanpour, Hiva Danesh, Fatemeh Bizhani, Behzad Narouie
Several studies examined the impact of miR-34b/c rs4938723 polymorphism and cancer risk, but the findings are inconsistent. However, no study has been conducted to inspect the impact of miR-34b/c polymorphism on bladder cancer. This study aimed to assess possible association between rs4938723 polymorphism and bladder cancer risk. This case-control study was done on 136 pathologically proven bladder cancer patients and 144 controls. Genotyping of Pri-miR-34b/c rs4938723 polymorphism was achieved by using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method...
September 6, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30174320/design-synthesis-and-biological-evaluation-of-selective-survivin-inhibitors
#3
Min Xiao, Yi Xue, Zhongzhi Wu, Zi-Ning Lei, Jin Wang, Zhe-Sheng Chen, Wei Li
The differential distribution between cancer cells and normal adult tissues makes survivin a very attractive cancer drug target. We have previously reported a series of novel selective survivin inhibitors with the most potent compound MX106 reaching nanomolar activity in several cancer cell lines. Further optimization of the MX106 scaffold leads to the discovery of more potent and more selective survivin inhibitors. Various structural modifications were synthesized and their anticancer activities were evaluated to determine the structure activity relationships for this MX106 scaffold...
August 31, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30174319/preparation-optimization-and-characterization-of-chitosan-coated-solid-lipid-nanoparticles-for-ocular-drug-delivery
#4
Fengzhen Wang, Mingwan Zhang, Dongsheng Zhang, Yuan Huang, Li Chen, Sunmin Jiang, Kun Shi, Rui Li
The present study aimed to develop and optimize chitosan coated solid lipid nanoparticles (chitosan-SLNs) encapsulated with methazolamide. Chitosan-SLNs were successfully prepared by a modified oil-in-water emulsification-solvent evaporation method with glyceryl monostearate as the solid lipid and phospholipid as the surfactant. Systematic screening of formulation factors was carried out. The optimized formula for preparation was screened by orthogonal design as well as Box-Behnken design with entrapment efficiency, particle size and zeta potential as the indexes...
August 31, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30057371/a-meta-analysis-of-caspase-8-652-6n-del-polymorphism-and-digestive-tract-cancer-risk
#5
Haina Du, Guoxin Song, Mingzhi Fang, Yong-Qian Shu, Xin Zhao, Ling-Jun Zhu
Caspase-8 (CASP8) is one key regulator of apoptosis of T lymphocytes and is encoded by the CASP8 gene. It has been reported that the six-nucleotide deletion polymorphism (-652 6N del) of the CASP8 gene had effect on some cancer risk. Few studies explored the association between CASP8 gene polymorphism and digestive tract cancer risk. To evaluate the association between the CASP8 -652 6N del polymorphism and the risk of digestive tract cancer, we conducted this meta-analysis. We found that CASP8-652 6N del polymorphism was associated with a significantly reduced risk of digestive tract cancer in the co-dominant model (del/del vs...
July 27, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30007953/bone-regeneration-with-adipose-derived-stem-cells-in-a-rabbit-model
#6
Michele Maglione, Enrico Salvador, Maria E Ruaro, Mauro Melato, Giuliana Tromba, Daniele Angerame, Lorenzo Bevilacqua
It has been shown that stem cells are able to calcify both in vitro and in vivo once implanted under the skin, if conveniently differentiated. Nowadays, however, a study on their efficiency in osseous regeneration does not exist in scientific literature and this very task is the real aim of the present experimentation. Five different defects of 6 mm in diameter and 2 mm in depth were created in the calvaria of 8 white New Zealand rabbits. Four defects were regenerated using 2 different conveniently modified scaffolds (Bio-Oss® Block and Bio-Oss Collagen®, Geistlich), with and without the aid of stem cells...
July 11, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30007952/antigenicity-of-tissues-and-organs-from-ggta1-cmah-%C3%AE-4galnt2-triple-gene-knockout-pigs
#7
Rong-Gen Wang, Miaomiao Ruan, Run-Jie Zhang, Lei Chen, Xiao-Xue Li, Bin Fang, Chu Li, Xue-Yang Ren, Ji-Ying Liu, Qiang Xiong, Li-Ning Zhang, Yong Jin, Lin Li, Rongfeng Li, Ying Wang, Hai-Yuan Yang, Yi-Fan Dai
Clinical xenotransplantations have been hampered by human preformed antibody-mediated damage of the xenografts. To overcome biological incompatibility between pigs and humans, one strategy is to remove the major antigens [Gal, Neu5Gc, and Sd(a)] present on pig cells and tissues. Triple gene (GGTA1, CMAH, and β 4GalNT2) knockout (TKO) pigs were produced in our laboratory by CRISPR-Cas9 targeting. To investigate the antigenicity reduction in the TKO pigs, the expression levels of these three xenoantigens in the cornea, heart, liver, spleen, lung, kidney, and pancreas tissues were examined...
July 11, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29970623/emerging-pathways-of-communication-between-the-heart-and-non-cardiac-organs
#8
Eugenio Hardy-Rando, Carlos Fernandez-Patron
The breakthrough discovery of cardiac natriuretic peptides provided the first direct demonstration of the connection between the heart and the kidneys for the maintenance of sodium and volume homeostasis in health and disease. Yet, little is still known about how the heart and other organs cross-talk. Here, we review three physiological mechanisms of communication linking the heart to other organs through: i) cardiac natriuretic peptides, ii) the microRNA-208a/mediator complex subunit-13 axis and iii) the matrix metalloproteinase-2 (MMP-2)/C-C motif chemokine ligand-7/cardiac secreted phospholipase A2 (sPLA2) axis - a pathway which likely applies to the many cytokines, which are cleaved and regulated by MMP-2...
July 2, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30047495/serial-lumbar-puncture-reduces-cerebrospinal-fluid-csf-infection-during-removal-of-hemorrhagic-csf-in-aneurysmal-subarachnoid-hemorrhage-after-endovascular-coiling
#9
Chen Liang, Ling Yang, Shiwen Guo
The present study aimed to compare the complications and clinical outcomes of serial lumbar puncture (LP) and lumbar cerebrospinal fluid (CSF) drainage (LD) of patients with aneurysmal subarachnoid hemorrhage and provide more evidence to guide clinical management. In this retrospective study, 41 and 39 aneurysmal subarachnoid hemorrhage patients were enrolled in the LP and LD group, respectively. Clinical outcomes, including CSF infection, intracerebral hemorrhage, vasospasm, hydrocephalus, death, length of stay, duration of drainage and the Glasgow Outcome Scale score were compared between the two groups...
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30008465/2-methyl-5h-benzo-d-pyrazolo-5-1-b-1-3-oxazin-5-imine-an-edaravone-analog-exerts-neuroprotective-effects-against-acute-ischemic-injury-via-inhibiting-oxidative-stress
#10
Huan-Yu Ni, Yi-Xuan Song, Hai-Yin Wu, Lei Chang, Chun-Xia Luo, Dong-Ya Zhu
Oxidative stress plays an indispensable role in the pathogenesis of cerebral ischemia. Inhibiting oxidative stress has been considered as an effective approach for stroke treatment. Edaravone, a free radical scavenger, has been shown to prevent cerebral ischemic injury. However, the clinical efficacy of edaravone is limited because it has a low scavenging activity for superoxide anions (O2 · - ). Here, we report that 2-methyl-5H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine, a novel small-molecule compound structurally related to edaravone, showed a stronger inhibitory effect on oxidative stress in vitro...
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30008464/pravastatin-alleviates-lipopolysaccharide-induced-placental-tlr4-over-activation-and-promotes-uterine-arteriole-remodeling-without-impairing-rat-fetal-development
#11
Mu-Yi Yang, Zhen-Yu Diao, Zhi-Yin Wang, Gui-Jun Yan, Guang-Feng Zhao, Ming-Ming Zheng, An-Yi Dai, Yi-Min Dai, Ya-Li Hu
Preeclampsia is associated with over-activation of the innate immune system in the placenta, in which toll-like receptor 4 (TLR4) plays an essential part. With their potent anti-inflammatory effects, statins have been suggested as potential prevention or treatment of preeclampsia, although evidence remains inadequate. Herewith, we investigated whether pravastatin could ameliorate preeclampsia-like phenotypes in a previously established lipopolysaccharide (LPS)-induced rat preeclampsia model, through targeting the TLR4/NF-κB pathway...
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30008463/dietary-vitamin-d-intake-and-vitamin-d-related-genetic-polymorphisms-are-not-associated-with-gastric-cancer-in-a-hospital-based-case-control-study-in-korea
#12
Sang-Yong Eom, Dong-Hyuk Yim, Dae-Hoon Kim, Hyo-Yung Yun, Young-Jin Song, Sei-Jin Youn, Taisun Hyun, Joo-Seung Park, Byung Sik Kim, Yong-Dae Kim, Heon Kim
There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic polymorphisms, and their association with the incidence of gastric cancer were investigated in a hospital case-control study, including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex...
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/30007954/identification-of-a-lmna-c-646c-t-variant-by-whole-exome-sequencing-in-combination-with-a-dilated-cardiomyopathy-dcm-related-gene-filter-in-a-family-with-familiar-dcm
#13
Liang Chen, Zhong-Yin Zhou, Hui-He Lu, Ye Xie, Gang Li, Jian-Fei Huang, Dong-Sheng Zhao
No abstract text is available yet for this article.
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29988026/luminal-extracellular-domains-of-chimeric-ci-m6pr-c-proteins-interfere-with-their-retrograde-endosome-to-tgn-trafficking-in-the-transient-expression-system
#14
Fei Chang, Na Li, Kang Yan, Yumin Huang, Hongfei Xu, Yongjian Liu
The membrane trafficking of cation-independent mannose 6-phosphate receptor (CI-M6PR) between the trans-Golgi network (TGN) and endosomal compartments is not only critical for maintaining lysosomal function but also a well-known event for understanding molecular and cellular mechanisms in retrograde endosome-to-TGN trafficking. Although it has been well established in literature that the C-terminus of bovine CI-M6PR determines its retrograde trafficking, it remains unclear whether the luminal domain of the protein plays a role on these sorting events...
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29970622/psychotic-due-to-bath-salts-and-methamphetamines-emergency-cesarean-section-under-general-anesthesia
#15
Nina Schloemerkemper
The use of "bath salts" or other new psychoactive substances, otherwise known as "legal highs", is increasing. Illicit drug use during pregnancy is not uncommon. Nevertheless, literature reporting bath salts and their effect on pregnancy is scant. Besides, there seems to be no literature about bath salts and conduct of general anesthesia. This case report describes a general anesthetic for the surgical delivery of an infant to a woman under the acute influence of bath salts and methamphetamines...
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29884775/a-novel-extradural-nerve-transfer-technique-by-coaptation-of-c4-to-c5-and-c7-to-c6-for-treating-isolated-upper-trunk-avulsion-of-the-brachial-plexus
#16
Kai-Xiang Yang, Shao-Hua Zhang, Da-Wei Ge, Tao Sui, Hong-Tao Chen, Xiao-Jian Cao
The study aimed to demonstrate the feasibility of an extradural nerve anastomosis technique for the restoration of a C5 and C6 avulsion of the brachial plexus. Nine fresh frozen human cadavers were used. The diameters, sizes, and locations of the extradural spinal nerve roots were observed. The lengths of the extradural spinal nerve roots and the distance between the neighboring nerve root outlets were measured and compared in the cervical segments. In the spinal canal, the ventral and dorsal roots were separated by the dura and arachnoid...
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29089470/pitavastatin-attenuates-ages-induced-mitophagy-via-inhibition-of-ros-generation-in-the-mitochondria-of-cardiomyocytes
#17
Zhi-Min Zha, Jun-Hong Wang, Shi-Ling Li, Yan Guo
This study aimed to investigate whether pitavastatin protected against injury induced by advanced glycation end products products (AGEs) in neonatal rat cardiomyocytes, and to examine the underlying mechanisms. Cardiomyocytes of neonatal rats were incubated for 48 hours with AGEs (100 μg/mL), receptor for advanced glycation end products (RAGE), antibody (1 μg/mL) and pitavastatin (600 ng/mL). The levels of p62 and beclin1 were determined by Western blotting. Mitochondrial membrane potential (ΔΨm) and the generation of reactive oxygen species (ROS) were measured through the JC-1 and DCFH-DA...
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28963446/clinical-features-of-multiple-myeloma-patients-with-isolated-extramedullary-relapse
#18
Xiao-Yan Qu, Li-Juan Chen, Tian Tian, Li-Min Duan, Rui-Nan Lu, Hua Lu, Han-Xin Wu, Jian-Yong Li
This study sought to analyze the clinical features and prognosis of multiple myeloma with isolated extramedullary relapse and with the absence of systemic progression. The clinical features and outcome were retrospectively analyzed in six multiple myeloma patients. These patients had secretory multiple myeloma at diagnosis. When relapsed, the dissociation between medullary and extramedullary response was detected. The serum or urine monoclonal component was extremely low or absent. The plasma cells in bone marrow were <5%...
July 23, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29921747/diagnostic-performance-of-contrast-enhanced-ultrasound-and-enhanced-magnetic-resonance-for-breast-nodules
#19
Cui-Ying Li, Hai-Yan Gong, Li-Jun Ling, Li-Wen Du, Tong Su, Shui Wang, Jie Wang
In the current study, we sought to evaluate the diagnostic efficacies of conventional ultrasound (US), contrast-enhanced US (CEUS), combined US and CEUS and magnetic resonance imaging (MRI) in detecting focal solid breast lesions. Totally 117 patients with 120 BI-RADS category 4A-5 breast lesions were evaluated by conventional US and CEUS, and MRI, respectively. SonoVue was used as contrast agent in CEUS and injected as an intravenous bolus; nodule scan was performed 4 minutes after bolus injection. A specific sonographic quantification software was used to obtain color-coded maps of perfusion parameters for the investigated lesion, namely the time-intensity curve...
June 1, 2018: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29752428/angiopoietin-like-protein-3-angptl3-deficiency-and-familial-combined-hypolipidemia
#20
Patrizia Tarugi, Stefano Bertolini, Sebastiano Calandra
Three members of the angiopoietin-like (ANGPTL) protein family-ANGPTL3, ANGPTL4 and ANGPTL8- are important regulators of plasma lipoproteins. They inhibit the enzyme lipoprotein lipase, which plays a key role in the intravascular lipolysis of triglycerides present in some lipoprotein classes. This review focuses on the role of ANGPTL3 as emerged from the study of genetic variants of Angptl3 gene in mice and humans. Both loss of function genetic variants and inactivation of Angptl3 gene in mice are associated with a marked reduction of plasma levels of triglyceride and cholesterol and an increased activity of lipoprotein lipase and endothelial lipase...
April 12, 2018: Journal of Biomedical Research
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