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Journal of Blood Medicine

Samaneh Abolbashari, Susan Darroudi, Maryam Tayefi, Zahra Khashyarmaneh, Parvin Zamani, Hamideh Moalemzadeh Haghighi, Amir Hooshang Mohammadpour, Shima Tavalaei, Mahsa Ahmadnezhad, Habibollah Esmaily, Gordon A Ferns, Zahra Meshkat, Majid Ghayour-Mobarhan
Introduction: Copper (Cu) and zinc (Zn) are important trace elements that are also structural ions of superoxide dismutase (SOD), which reduce oxidative stress. Zinc deficiency and excess copper have been reported to be associated with inflammation. The human T-lymphotropic virus type 1 (HTLV-1) is a retrovirus, which is believed to cause systemic inflammation. The aim of this study is to measure levels of Zn, Cu, SOD, and prooxidant-antioxidant balance (PAB) in HTLV-1-positive patients and investigate the association between serum Zn and Cu concentrations and levels of oxidative stress in them...
2019: Journal of Blood Medicine
Rolando Innocenti, Luigi Rigacci, Umberto Restelli, Barbara Scappini, Giacomo Gianfaldoni, Rosa Fanci, Francesco Mannelli, Francesca Scolari, Davide Croce, Erminio Bonizzoni, Tania Perrone, Alberto Bosi
Purpose: We conducted a retrospective study to evaluate the efficacy and related costs of using two different molecules of granulocyte-colony stimulating factor (G-CSF) (lenograstim - LENO or filgrastim - FIL) as primary prophylaxis of chemotherapy-induced neutropenia in a hematological inpatient setting. Methods: The primary endpoints of the analysis were the efficacy of the two G-CSFs in terms of the level of white blood cells, hemoglobin and platelets at the end of the treatment and the per capita direct medical costs related to G-CSF prophylaxis...
2019: Journal of Blood Medicine
(no author information available yet)
[This retracts the article on p. 163 in vol. 9, PMID: 30323700.].
2019: Journal of Blood Medicine
Wilson L Mandala, Esther N Gondwe, Tonney S Nyirenda, Mark Drayson, Malcolm E Molyneux, Calman A MacLennan
Aim: Cerebral malaria (CM), unlike severe malarial anemia (SMA), has previously been characterized by pan-lymphopenia that normalizes in convalescence, while HIV infection is associated with depletion of CD4+ T cells. In this study, we investigate whether HIV infection in Malawian children exacerbates the pan-lymphopenia associated with CM. Methods: We investigated the absolute and percentage lymphocyte-subset counts and their activation and memory status in Malawian children presenting with either CM who were HIV-uninfected (n=29), HIV-infected (n=9), or SMA who were HIV-uninfected (n=30) and HIV-infected (n=5) in comparison with HIV-uninfected children without malaria (n=42) and HIV-infected children without malaria (n=4)...
2019: Journal of Blood Medicine
Shosaku Nomura, Tomoki Ito, Atsushi Satake, Kazuyoshi Ishii
Background: The outcome for chronic myelogenous leukemia (CML) patients presented in the chronic phase has changed dramatically since the introduction of tyrosine kinase inhibitor (TKI) therapy. Notably, an increased incidence of large granular lymphocytes (LGLs), which is related to immunological conditions, appears to be predictive of a favorable outcome for dasatinib therapy. We therefore examined the immunological characteristics of CML patients during dasatinib therapy by determining the plasma concentrations of five different biomarkers...
2019: Journal of Blood Medicine
Mohamed El-Shanshory, Nahed M Hablas, Yasmin Shebl, Ahmed R Fakhreldin, Mohamed Attia, Hamdi H Almaramhy, Hussam Baghdadi, Mongi Ayat, Amal Albeihany, Amr El-Dardear, Hoda Ali Ibrahim, Hany Salah Mahmoud, Manal Mohamed Helmy Nabo, Salah Mohamed El Sayed
Background: Thalassemia is a major health problem due to iron overload, iron deposition and oxidative stress-induced tissue damage. Here, we introduce Al-hijamah (a minor surgical excretory procedure) as a novel percutaneous iron excretion therapy. Al-hijamah is a wet cupping therapy of prophetic medicine, and prophet Muhammad, peace be upon him, strongly recommended Al-hijamah, saying: "The best of your treatment is Al-hijamah". Aim of the study: Our study aimed at investigating the safety, iron chelation, pharmacological potentiation and oxidant clearance effects exerted by Al-hijamah to thalassemic children...
2018: Journal of Blood Medicine
Madhvi Rajpurkar, David L Cooper
Introduction: Continuous infusion (CI) of clotting factors as a replacement therapy for perioperative hemostatic protection has been performed for many years, including with factors VIII and IX and recombinant activated factor VII (rFVIIa). This approach provides steady factor levels without requiring frequent administration of bolus doses. Aim: To review safety, efficacy, and dosing data regarding CI of rFVIIa for hemostatic management of patients with congenital hemophilia with inhibitors (CHwI) or congenital factor VII deficiency (C7D)...
2018: Journal of Blood Medicine
Keneth Mandu, Sharifu K Tusuubira, Bashir Mwambi, Fred Webbo, Christine Atuhairwe, Ivan Mugisha Taremwa
Purpose: To evaluate the occurrence of sickle cell trait (SCT), assess patient awareness and evaluate the performance of a sickle cell hemoglobin-S (dithionate-qualitative solubility) point-of-care test among patients seeking care at Magale Health Center IV, Namisindwa District, Eastern Uganda. Materials and methods: We conducted a cross sectional study, in which we consecutively enrolled participants aged ≥18 years at Magale Health Center IV. Four milliliters of EDTA blood were collected by venipuncture and screened for SCT using solubility testing, and confirmed with hemoglobin (Hb) electrophoresis at Central Public Health Laboratory (CPHL), Kampala, Uganda...
2018: Journal of Blood Medicine
Shilpa Jain, Jennifer Donkin, Mary-Jane Frey, Skye Peltier, Sriya Gunawardena, David L Cooper
Background: One of the most common rare inherited bleeding disorders, congenital factor VII (FVII) deficiency typically has a milder bleeding phenotype than other rare bleeding disorders. Categorizing severity in terms of factor activity associated with hemophilia (severe <1%, moderate 1%-5%, mild 6%-40%) has led to the observation that bleeding phenotype does not follow closely with FVII activity. Over the past decade, large-scale global registries have investigated bleeding phenotype more thoroughly...
2018: Journal of Blood Medicine
Charles Antwi-Boasiako, Ivy Ekem, Mubarak Abdul-Rahman, Frederika Sey, Alfred Doku, Bartholomew Dzudzor, Gifty B Dankwah, Kate Hagar Otu, John Ahenkorah, Robert Aryee
Background: Effective treatment and management of sickle cell disease (SCD) has been a challenge in Africa over the years. Hematological parameters are very useful profiles in the effective management of the disease. However, there is scarcity of studies on the hematological parameters of SCD in Ghana. This study aimed at determining hematological parameters among SCD patients with vaso-occlusion, those in the steady state as well as healthy controls at a teaching hospital in Ghana. Methodology: This was a cross-sectional study involving a total of 628 subjects, including 148 HbAA controls, 208 HbSS patients in steady state, 82 HbSC patients in steady state, 156 HbSS patients in vaso-occlusive crises (VOC), and 34 HbSC patients in VOC...
2018: Journal of Blood Medicine
Apollo Ocan, Caesar Oyet, Fred Webbo, Bashir Mwambi, Ivan Mugisha Taremwa
Aim/objective: The aim of this study was to determine the prevalence, severity, morphological characterization, and the associated factors of anemia among children under the age of 5 years at St. Mary's Hospital Lacor, Gulu District, Northern Uganda. Materials and methods: A structured questionnaire was administered to each participant's parent/caregiver to collect data on sociodemographic factors, feeding pattern, and history of chronic illness. Hemoglobin (Hb) estimation was performed using a HemoCue 201+ analyzer...
2018: Journal of Blood Medicine
(no author information available yet)
[This corrects the article on p. 87 in vol. 3, PMID: 22977316.].
2018: Journal of Blood Medicine
Diane J Nugent, Alicia A Romano, Shreya Sabharwal, David L Cooper
Background: Noonan syndrome (NS) is an autosomal dominant genetic condition that has a number of clinical features, including bleeding diathesis and a number of hematological abnormalities including clotting factor deficiencies, von Willebrand disease and abnormal platelet count/function. Methods: We evaluated the frequency/types of bleeding disorders, and associated hematological laboratory findings, in patients with NS, using published data from 1965 to 2014. Results: Of 45 studies identified, 31 included data for 428 patients with NS...
2018: Journal of Blood Medicine
José Carlos Jaime-Pérez, Patrizia Elva Aguilar-Calderón, Lorena Salazar-Cavazos, David Gómez-Almaguer
Evans syndrome (ES) is a rare and chronic autoimmune disease characterized by autoimmune hemolytic anemia and immune thrombocytopenic purpura with a positive direct anti-human globulin test. It is classified as primary and secondary, with the frequency in patients with autoimmune hemolytic anemia being 37%-73%. It predominates in children, mainly due to primary immunodeficiencies or autoimmune lymphoproliferative syndrome. ES during pregnancy is associated with high fetal morbidity, including severe hemolysis and intracranial bleeding with neurological sequelae and death...
2018: Journal of Blood Medicine
Saeed Baradwan, Abdullah Alyousef, Abdulrhman Turkistani
Background: Iron deficiency anemia (IDA) during pregnancy is a common and preventable disorder. It remains a contributing factor to maternal morbidity and mortality and is associated with high perinatal mortality rates. Objective: To determine the prevalence of IDA and its associated clinical features among pregnant women. Methods: This analytical prospective cohort study included 1,579 pregnant women who attended an antenatal clinic, Women's Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia, between January 2018 and April 2018...
2018: Journal of Blood Medicine
Alinane U Munyenyembe, Kamunkhwala Gausi, Tonney S Nyirenda, Jasmin Hiestand, Jane Mallewa, Wilson L Mandala
Aim: Although malaria and HIV infections independently affect the electrolyte and hematologic profiles, little is known of how these profiles are affected in individuals coinfected with malaria and HIV. We therefore conducted this study to investigate the electrolyte and hematologic profiles of Malawian adults presenting with either uncomplicated malaria (UM), severe malaria (SM), and those presenting with HIV and UM or HIV and SM. Methods: Study participants were recruited at Queen Elizabeth Central Hospital, and malaria infection was confirmed by rapid diagnostic test and malaria slides, and full blood count, HIV, and wet chemistries were analyzed...
2018: Journal of Blood Medicine
Adnan I Al-Hindi, Omar F Khabour, Karem H Alzoubi, Nour A Al-Sawalha
Introduction: Blood donation is important for saving human life as blood is used in surgeries, blood transfusion and for clinical use. The mission of blood banks can be extended to include medical research. The objective of the study was to determine and assess the attitude of blood donors in Gaza towards the use of their blood samples and medical data for biomedical research and the associated ethical issues. Methods: The study is cross-sectional and questionnaire-based and involved 616 blood donors from the Gaza Strip...
2018: Journal of Blood Medicine
Arwa Lardhi, Rania Alhaj Ali, Rola Ali, Tarek Mohammed
Vitamin B12 is essential for proper neurological functioning, and its deficiency may cause a wide range of neuropsychiatric and hematological manifestations. We report a case of a previously healthy 32-year-old female who was admitted to our hospital with sudden onset of bilateral lower limb paraparesis and loss of sensation. The serum level of vitamin B12 was mildly decreased with high methylmalonic acid and homocysteine levels. However, her complete blood count showed no evidence of anemia or macrocytosis; instead, her mean corpuscular volume was low...
2018: Journal of Blood Medicine
Nicoletta Machin, Margaret V Ragni
Fitusiran is an RNA interference therapeutic that targets antithrombin (AT) in the liver and interferes with AT translation by binding and degrading messenger RNA-AT, thereby silencing AT gene expression and preventing AT synthesis. In both preclinical and clinical studies, AT knockdown results in dose-dependent AT lowering when fitusiran is given weekly or monthly subcutaneously. In clinical trials, fitusiran dose escalation has resulted in improved thrombin generation and clinical hemostasis as measured by reduction in annualized bleed rate...
2018: Journal of Blood Medicine
Timothy H Pohlman, Alison M Fecher, Cecivon Arreola-Garcia
From clinical and laboratory studies of specific coagulation defects induced by injury, damage control resuscitation (DCR) emerged as the most effective management strategy for hemorrhagic shock. DCR of the trauma patient who has sustained massive blood loss consists of 1) hemorrhage control; 2) permissive hypotension; and 3) the prevention and correction of trauma-induced coagulopathies, referred to collectively here as acute coagulopathy of trauma (ACOT). Trauma patients with ACOT have higher transfusion requirements, may eventually require massive transfusion, and are at higher risk of exsanguinating...
2018: Journal of Blood Medicine
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