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International Forum of Allergy & Rhinology

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https://www.readbyqxmd.com/read/29028287/a-validated-model-for-the-22-item-sino-nasal-outcome-test-subdomain-structure-in-chronic-rhinosinusitis
#1
Allen L Feng, Nicholas C Wesely, Lloyd P Hoehle, Katie M Phillips, Alisa Yamasaki, Adam P Campbell, Luciano L Gregorio, Thomas E Killeen, David S Caradonna, Josh C Meier, Stacey T Gray, Ahmad R Sedaghat
BACKGROUND: Previous studies have identified subdomains of the 22-item Sino-Nasal Outcome Test (SNOT-22), reflecting distinct and largely independent categories of chronic rhinosinusitis (CRS) symptoms. However, no study has validated the subdomain structure of the SNOT-22. This study aims to validate the existence of underlying symptom subdomains of the SNOT-22 using confirmatory factor analysis (CFA) and to develop a subdomain model that practitioners and researchers can use to describe CRS symptomatology...
October 13, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29028274/the-2017-13-th-annual-david-w-kennedy-md-lecture-the-evolution-of-outcomes-in-sinus-surgery-for-chronic-rhinosinusitis-past-present-and-future
#2
Timothy L Smith
This is an edited transcript from the 2017 13th Annual David W. Kennedy, MD, Lecture, presented to the American Rhinologic Society during the 63rd Annual Meeting.
October 13, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29024522/in-vitro-safety-evaluation-of-human-nasal-epithelial-cell-monolayers-exposed-to-carrageenan-sinus-wash
#3
Mahnaz Ramezanpour, Jae Murphy, Jason L P Smith, Sarah Vreugde, Alkis James Psaltis
BACKGROUND: Carrageenans have shown to reduce the viral load in nasal secretions and lower the incidence of secondary infections in children with common cold. Despite the widespread use of carrageenans in topical applications, the effect of carrageenans on the sinonasal epithelial barrier has not been elucidated. We investigate the effect of different carrageenans on the sinonasal epithelial barrier and inflammatory response in vitro. METHODS: Iota and Kappa carrageenan delivered in saline irrigation solutions applied to air-liquid interface (ALI) cultures of primary human nasal epithelial cells from chronic rhinosinusitis patients and controls...
October 12, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29024520/allergen-immunotherapy-exploring-areas-for-further-inquiry
#4
Tam Ramsey, Wanda Lai, Peter F Svider, Houmehr Hojjat, Jean Anderson Eloy, Adam J Folbe
BACKGROUND: Allergy-related illness impacts millions of individuals worldwide. Our objectives were to characterize current trends of clinical trials research relating to allergen immunotherapy and to describe the landscape of allergen immunotherapy in National Institutes of Health (NIH)-supported research inquiry. METHODS: On ClinicalTrials.gov, the following terms were searched: allergen immunotherapy OR allergy immunotherapy. Variables, including completion status, dates, design, study population, funder, location, and allergen were recorded...
October 12, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29024448/isolated-sphenoid-sinus-opacifications-a-systematic-review-and-meta-analysis
#5
REVIEW
William J Moss, Andrey Finegersh, Aria Jafari, Bharat Panuganti, Charles S Coffey, Adam DeConde, Jacob Husseman
BACKGROUND: Isolated sphenoid sinus opacifications (ISSOs) represent a relatively uncommon disease with the potential for serious complications. To better understand this disease, we performed a systematic review to further characterize the underlying pathologies, associated symptoms, and treatment outcomes of patients with ISSOs. METHODS: A systematic review of ISSO case series was performed utilizing the Medline, Embase, Web of Science, and Cochrane databases in accordance with guidelines established by PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses)...
October 12, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28985037/postoperative-sinonasal-morbidity-in-sellar-reconstruction-mucosal-autograft-versus-acellular-dermal-allograft
#6
Christopher R Roxbury, J Trent Magruder, Murugappan Ramanathan, Michael Lim, Gary L Gallia, Masaru Ishii, Douglas D Reh
BACKGROUND: Sellar pathology is increasingly addressed using the expanded endonasal approach (EEA). Although avascular graft reconstruction is an acceptable means to prevent cerebrospinal fluid leak, there are few data regarding sinonasal morbidity in these patients. In this study we compare rates of persistent postoperative crusting (PPC) and rhinosinusitis in patients undergoing sellar reconstruction with mucosal autografting and acellular dermal allografting (ADA). METHODS: Patients undergoing the EEA between 2008 and 2014 were categorized into 2 subgroups: mucosal reconstruction and ADA reconstruction...
October 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28985031/trends-in-sinusitis-research-a-systematic-review-of-extramural-funding
#7
Joshua M Levy, Stephanie Shintani Smith, Rickul Varshney, Eugene H Chang, Vijay R Ramakrishnan, Jonathan Y Ting, Benjamin S Bleier
BACKGROUND: Innovation represents a core value of the American Rhinologic Society (ARS), with multiple efforts to promote research in the advancement rhinologic care. We therefore sought to identify trends in extramural sinusitis funding and underutilized sources of support to facilitate future efforts. METHODS: A systematic review of the National Institutes of Health (NIH) Research Portfolio Online Tools (RePORTER) database (fiscal year 1993 to 2017) was completed with the search strategy: ("chronic sinusitis" OR rhinosinusitis)...
October 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28941212/the-impact-of-surgical-wait-time-on-patient-reported-outcomes-in-sinus-surgery-for-chronic-rhinosinusitis
#8
Ethan Newton, Arif Janjua, Ernest Lai, Guiping Liu, Trafford Crump, Jason M Sutherland
BACKGROUND: In many developed countries, wait times for elective surgery are increasing. Among these elective surgeries is endoscopic sinus surgery (ESS) performed for treatment of chronic rhinosinusitis (CRS). Little is known about the impact of wait times on patients' surgical outcomes. The purpose of this study was to evaluate the association between patients' wait times and postoperative patient-reported outcomes. METHODS: This study was based on a prospectively recruited longitudinal cohort of patients booked for ESS for the treatment of medically-refractory CRS in Vancouver, Canada...
September 22, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28941169/three-dimensional-image-analysis-for-staging-chronic-rhinosinusitis
#9
Sooyoung Lim, Michael V Ramirez, Jonathan C Garneau, Megan K Ford, Katherine McKeough, Daniel T Ginat, Fuad M Baroody, Samuel G Armato, Jayant M Pinto
BACKGROUND: Traditional methods of staging chronic rhinosinusitis (CRS) through imaging do not differentiate between degrees of partial mucosal sinus inflammation, thus limiting their utility as imaging biomarkers. We hypothesized that software-aided, quantitative measurement of sinus inflammation would generate a metric of disease burden that would correlate with clinical parameters in patients with suspected sinus disease. METHODS: Adults with rhinologic complaints undergoing computed tomography imaging were recruited at an urban, academic, tertiary care center (n = 45 with Lund-Mackay [LM] scores ≥4)...
September 22, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28941136/comparison-of-surgical-outcomes-between-patients-with-unilateral-and-bilateral-chronic-rhinosinusitis
#10
Daniel M Beswick, Jess C Mace, Naweed I Chowdhury, Jeremiah A Alt, Peter H Hwang, Adam S DeConde, Timothy L Smith
BACKGROUND: Although the majority of patients with chronic rhinosinusitis without nasal polyposis (CRSsNP) suffer from bilateral disease, a subset suffer from unilateral disease. Currently, outcomes following endoscopic sinus surgery (ESS) for medically recalcitrant CRS are inferred from outcomes for patients with bilateral disease. This study compares outcomes of ESS between patients with unilateral and bilateral disease. METHODS: Patients with CRSsNP who failed appropriate medical therapy and elected ESS were enrolled between 2011 and 2015...
September 22, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28922579/evaluating-real-time-effects-of-topical-1-1000-epinephrine-in-endoscopic-sinus-and-skull-base-surgery-on-hemodynamic-parameters-through-intraoperative-arterial-line-monitoring
#11
Michael T Yim, Omar G Ahmed, Masayoshi Takashima
BACKGROUND: Administration of topical 1:1000 epinephrine is commonly used in practice to achieve vasoconstriction during endoscopic sinus surgery and skull-base surgery; however, real-time effects on cardiovascular changes from systemic absorption have not been well studied. METHODS: Twenty-six patients undergoing endoscopic transsphenoidal resection of a pituitary lesion at a single institution were included into the study. Following arterial line placement by anesthesiology, 6 cottonoid pledgets soaked in 1:1000 epinephrine were placed into the bilateral nasal passages...
September 18, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28881424/anatomic-relationship-of-the-first-olfactory-neuron-and-trochlea-cadaveric-study-with-surgical-implications
#12
Philip Locker, Max Plitt, Peter Papagiannopoulos, Ryan Smith, Bobby A Tajudeen
BACKGROUND: Iatrogenic injury to the trochlea is a potential complication of the Draf III or endoscopic modified Lothrop procedure; however, the location of the trochlea from within the sinus cavity has yet to be clearly characterized. We performed the first cadaveric study assessing the position of the trochlea in relation to the first olfactory neuron, a commonly identified landmark during the Draf III procedure. METHODS: Thirteen external dissections of the trochlea were performed on 7 disarticulated cadaveric heads via an extended Lynch type incision...
September 7, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28873286/the-impact-of-asthma-on-the-cost-effectiveness-of-surgery-for-chronic-rhinosinusitis-with-nasal-polyps
#13
George A Scangas, Aaron K Remenschneider, Brooke M Su, Mark G Shrime, Ralph Metson
BACKGROUND: The objective of this work was to evaluate the impact of asthma on the cost-effectiveness profile of endoscopic sinus surgery (ESS) compared to medical therapy for patients with chronic rhinosinusitis with nasal polyps (CRSwNP). METHODS: The study design consisted of a cohort-style Markov decision-tree cost utility analysis with a 35-year time horizon. Matched cohorts of CRSwNP patients with (n = 95) and without (n = 95) asthma who underwent ESS were compared with cohorts of patients from the national Medical Expenditures Survey Panel (MEPS) database who underwent medical management for chronic rhinosinusitis (CRS)...
September 5, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28863237/a-prospective-analysis-evaluating-tissue-biopsy-location-and-its-clinical-relevance-in-chronic-rhinosinusitis-with-nasal-polyps
#14
Ava R Weibman, Julia He Huang, Whitney W Stevens, Lydia A Suh, Caroline P E Price, Alcina K Lidder, David B Conley, Kevin C Welch, Stephanie Shintani-Smith, Anju T Peters, Leslie C Grammer, Atsushi Kato, Robert C Kern, Robert P Schleimer, Bruce K Tan
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) has a high propensity for recurrence. Studies suggest that eosinophilia influences disease severity and surgical outcomes, but the selection of sinonasal site for measuring eosinophilia has not been examined. The aim of this study was to investigate how region-specific tissue eosinophilia affects radiographic severity, comorbidity prevalence, and polyp recurrence risk following sinus surgery. METHODS: Eosinophil cationic protein (ECP) levels in uncinate tissue (UT) and nasal polyp (NP) homogenates from 116 CRSwNP patients were measured using enzyme-linked immunosorbent assay (ELISA)...
September 1, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28863235/therapeutic-potential-of-%C3%AE-lipoic-acid-derivative-sodium-zinc-histidine-dithiooctanamide-in-a-mouse-model-of-allergic-rhinitis
#15
Toshiaki Nakano, Li-Wen Hsu, Chia-Yun Lai, Yuki Takaoka, Masafumi Inomata, Seigo Kitano, Chao-Long Chen, Shigeru Goto
BACKGROUND: Oxidative stress is involved in various diseases, including allergies. Several studies have pointed to the preventive and therapeutic potential of antioxidants in allergic disorders. However, little is known about the immunomodulatory effects of antioxidants in type I hypersensitivity. In this study we aimed to explore the impact of a water-soluble antioxidant and α-lipoic acid derivative, sodium zinc histidine dithiooctanamide (DHL-HisZn), on mast-cell- and T-cell-mediated allergic and immune responses both in vitro and in vivo...
September 1, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28859245/comparison-of-the-effect-of-aerosolized-fibrin-sealant-and-biodegradable-synthetic-polyurethane-foam-on-hemostasis-and-wound-healing-after-endoscopic-sinus-surgery-a-prospective-randomized-study
#16
Moon Sik Jung, Chang Hwan Choi, Myeong Sang Yu
BACKGROUND: Use of absorbable packing materials after functional endoscopic sinus surgery (FESS) is associated with increased patient comfort and a lack of need for packing removal. Different materials may induce different patterns of mucosal healing and hemostasis. This study investigated the effect of fibrin sealant (FS; Tisseel) or biodegradable synthetic polyurethane foam (Nasopore(®) ) packing on hemostasis and wound healing after FESS. METHODS: This prospective randomized controlled trial included 35 consecutive patients who underwent bilateral FESS for chronic rhinosinusitis...
August 31, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28853224/response-to-letter-to-the-editor-regarding-changing-the-surgical-dogma-in-frontal-sinus-trauma-transnasal-endoscopic-repair
#17
LETTER
Jessica W Grayson, Hari Jeyarajan, Elisa A Illing, Do-Yeon Cho, Kristen O Riley, Bradford A Woodworth
No abstract text is available yet for this article.
August 29, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28843038/in-response-to-changing-the-surgical-dogma-in-frontal-sinus-trauma-transnasal-endoscopic-repair-by-grayson-et-al
#18
LETTER
Kiruba Shankar, Alok Thakar, S C Sharma
No abstract text is available yet for this article.
August 26, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28843029/a-retrospective-analysis-of-538-sinonasal-fungus-ball-cases-treated-at-a-single-tertiary-medical-center-in-korea-1996-2015
#19
Young Hoon Yoon, Jun Xu, Soo Kyoung Park, Jae Hyung Heo, Yong Min Kim, Ki-Sang Rha
BACKGROUND: Sinonasal fungus ball (FB) is a type of noninvasive fungal rhinosinusitis affecting immunocompetent hosts. FB, previously considered rare, has been reported with increasing frequency. We reviewed our experience of 538 cases over the past 20 years. METHODS: We retrospectively examined clinical records including clinical presentations, radiological findings, management, and outcomes of FB patients who have undergone surgery for treatment. The number of FB patients who underwent endoscopic sinus surgery (ESS) was calculated annually...
August 26, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28834622/development-of-the-endoscopic-endonasal-sinus-and-skull-base-surgery-questionnaire
#20
Ellen Ten Dam, Robert A Feijen, Minke J C van den Berge, Eelco W Hoving, Jos M Kuijlen, Bernard F A M van der Laan, Karin M Vermeulen, Paul F M Krabbe, Astrid G W Korsten-Meijer
BACKGROUND: The patients' perspective of health outcomes has become important input for assessing treatment effects. However, existing endoscopic endonasal surgery (EES) instruments are not fully aligned with the concept of health-related quality of life (HRQoL). A prospective cohort study was therefore conducted to develop a suitable quality-of-life tool to assess nasal morbidity after EES: the Endoscopic Endonasal Sinus and Skull Base Surgery Questionnaire (EES-Q). METHODS: The study included 300 patients: 207 with sinus pathology and 93 with anterior skull base pathology...
August 23, 2017: International Forum of Allergy & Rhinology
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