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International Forum of Allergy & Rhinology

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https://www.readbyqxmd.com/read/28318142/finding-clinical-efficacy-with-balloon-sinus-dilation-in-pediatric-chronic-rhinosinusitis-patients
#1
LETTER
Gary J Nishioka
No abstract text is available yet for this article.
March 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28318118/distinct-expression-of-nk2-homeobox-1-nkx2-1-and-goblet-cell-hyperplasia-in-nasal-polyps-with-different-endotypes
#2
Jintao Du, Luo Ba, Bo Li, Feng Liu, Xianting Hu, Jie Zhang, Yafeng Liu, Junming Xian, Sixi Liu, Huabin Li
BACKGROUND: Decreased expression of airway epithelial-specific transcription factor NK2 homeobox 1 (NKX2-1) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2-1 in nasal polyps (NPs) with different endotypes were undefined yet. METHODS: We examined the expression of key cytokines (interleukin [IL]-4 IL-5, IL-13, and IL-17A, etc.) and NKX2-1 in NPs with different endotypes and control tissues by immunohistochemistry staining, qualitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA), and Western blot analysis...
March 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28296272/ergonomic-analysis-of-the-surgical-position-in-functional-endoscopic-sinus-surgery
#3
Vijay R Ramakrishnan, Benjamin M Milam
BACKGROUND: Ergonomics is the methodologic study of people's efficiency in their work environment and is based on anatomy, physiology, psychology, and engineering. Although highly studied in other work environments, little attention has been paid to surgeons until the landmark survey by Park et al in 2010. Many unique aspects of endoscopic surgery amplify task-related physical discomfort, and, because of these issues, we aimed to study the physical fatigue effects of functional endoscopic sinus surgery (FESS) performed in the standing and sitting positions...
March 15, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28296288/effect-of-diabetes-mellitus-on-postoperative-endoscopic-sinus-surgery-outcomes
#4
Andrey Filimonov, Sei Yeon Chung, Anni Wong, Jacob S Brady, Soly Baredes, Jean Anderson Eloy
BACKGROUND: Endoscopic sinus surgery (ESS) has become the treatment of choice for a variety of nasal conditions. The purpose of this study was to analyze the effect of diabetes mellitus (DM) on postoperative outcomes in ESS. METHODS: Data on endoscopic sinus surgery performed from 2005 to 2013 were collected from the American College of Surgeons National Surgical Quality Improvement (ACS-NSQIP) database. Two groups were created, based on the presence of a DM diagnosis, and were analyzed for preoperative variables, comorbidities, and postoperative complications using SPSS statistical software...
March 10, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28272841/does-positive-airway-pressure-therapy-improve-olfactory-function
#5
Sabri Koseoğlu, Serhan Derin, Mustafa Yilmaz, Gulnihal Kutlu, Murat Sahan
BACKGROUND: Olfactory function deteriorates in patients with severe obstructive sleep apnea syndrome (OSAS). The effect of positive airway pressure (PAP) therapy on olfactory function has not been investigated before. In this study, we aimed to investigate the role of PAP therapy on olfactory impairment in patients with OSAS. METHODS: Thirty patients who had OSAS and planned for PAP therapy were included in the study. All participants underwent a detailed otorhinolaryngological examination and polysomnography...
March 8, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28272838/mortality-risk-in-patients-with-chronic-rhinosinusitis-and-its-association-to-asthma
#6
Jeremiah A Alt, Andrew J Thomas, Karen Curtin, Jathine Wong, Luke Rudmik, Richard R Orlandi
BACKGROUND: Chronic rhinosinusitis (CRS) is a highly prevalent inflammatory condition, with significant effects on morbidity and quality of life. Given that other chronic inflammatory conditions have been associated with increased mortality risk, we sought to evaluate the relationship between mortality and CRS including the influence of asthma. Our objective was to determine if CRS, with or without asthma, is associated with altered risk of mortality. METHODS: Using a statewide population database, we retrospectively identified 27,005 patients diagnosed with CRS between 1996 and 2012, and 134,440 unaffected controls matched 5:1 on birth year and sex...
March 8, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28236375/discordant-frequencies-of-tissue-resident-and-circulating-cd180-negative-b-cells-in-chronic-rhinosinusitis
#7
Dijana Miljkovic, Judy Ou, Chandra Kirana, Kathryn E Hulse, Ehud Hauben, Alkis Psaltis, Peter-John Wormald, Sarah Vreugde
BACKGROUND: The unconventional toll-like receptor (TLR) CD180 is implicated in chronic inflammatory diseases; however, its role in chronic rhinosinusitis (CRS) has yet to be investigated. Here we study the expression of CD180, its homologue TLR4 and myeloid differentiation factor 1 (MD1) on mucosal and systemic immune cell populations in relation to serum immunoglobulin G (IgG) levels. METHODS: A total of 70 patients were recruited to the study. Mucosal and peripheral blood samples were prospectively collected from CRS patients and non-CRS controls without evidence of sinus disease...
February 25, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28236359/single-nucleotide-polymorphisms-related-to-cystic-fibrosis-in-chronic-rhinositus-a-pilot-study
#8
Benjamin P Hull, Pawina Jiramongkolchai, Justin H Turner, Lana Olson, Rakesh K Chandra
BACKGROUND: The clinical association between cystic fibrosis (CF) and chronic rhinosinusitis (CRS) is well known. Studies have identified several non-CF transmembrane conductance regulator single nucleotide polymorphisms (SNPs) associated with disease severity in CF patients. We hypothesized that prevalence of these SNPs would be different between CRS patients and age/gender-matched non-CRS controls. METHODS: This is a targeted SNP study of 1231 CRS patients identified through a large university hospital database who were compared with 8796 age- and gender-matched controls without a history of rhinitis, sinusitis, allergies, or asthma...
February 25, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28218486/determinants-and-outcomes-of-upfront-surgery-versus-medical-therapy-for-chronic-rhinosinusitis-in-cystic-fibrosis
#9
Noel Ayoub, Andrew Thamboo, Al-Rahim Habib, Jayakar V Nayak, Peter H Hwang
BACKGROUND: The indications for surgical management of chronic rhinosinusitis (CRS) in patients with cystic fibrosis (CF) are poorly defined. In this study we compare outcomes of medical versus surgical treatment and examine trends associated with the transition from medical to surgical therapy in CF patients. METHODS: One hundred thirty-six patients with CF referred to a tertiary rhinology practice were retrospectively divided into 3 cohorts: Medical, Upfront Surgery, or Crossover, if they converted from medical to surgical management...
February 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28207197/changing-the-surgical-dogma-in-frontal-sinus-trauma-transnasal-endoscopic-repair
#10
Jessica W Grayson, Hari Jeyarajan, Elisa A Illing, Do-Yeon Cho, Kristen O Riley, Bradford A Woodworth
BACKGROUND: Management of frontal sinus trauma includes coronal or direct open approaches through skin incisions to either ablate or obliterate the frontal sinus for posterior table fractures and openly reduce/internally fixate fractured anterior tables. The objective of this prospective case-series study was to evaluate outcomes of frontal sinus anterior and posterior table trauma using endoscopic techniques. METHODS: Prospective evaluation of patients undergoing surgery for frontal sinus fractures was performed...
February 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28207194/clinical-outcomes-of-sinonasal-squamous-cell-carcinomas-based-on-tumor-etiology
#11
Carol H Yan, Jason G Newman, David W Kennedy, James N Palmer, Nithin D Adappa
BACKGROUND: Squamous cell carcinoma (SCC) of the sinonasal cavity is a rare entity that arises as either de-novo tumors or from inverted papillomas (IPs). In this study we evaluate and compare oncologic outcomes of sinonasal SCCs based on their etiology and treatment strategy. METHODS: This investigation was a single-center, retrospective review comparing de-novo SCCs (n = 28) and those associated with IPs (n = 38) resected during the period from 2000 to 2015. Demographic and tumor data, surgical approach, recurrence, and clinical outcomes were analyzed...
February 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28182336/f508del-genotype-in-endoscopic-sinus-surgery-do-differences-in-outcomes-exist-between-genotypic-subgroups
#12
Ashleigh A Halderman, Natalie West, James Benke, Christopher R Roxbury, Sandra Y Lin
BACKGROUND: The impact of endoscopic sinus surgery (ESS) on pulmonary function in cystic fibrosis (CF) patients with chronic rhinosinusitis remains unclear, as studies have demonstrated conflicting results. To date, no study has looked specifically at the impact of CF genotype on lung function after ESS. In this study, we reviewed changes in pulmonary function test (PFT) results after ESS in F508del homozygotes and heterozygotes. METHODS: The charts of 25 patients with CF without prior lung transplant, who underwent ESS performed by the same surgeon between the period of July 2005 to July 2015, were retrospectively reviewed...
February 9, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28182334/utility-of-intraoperative-frozen-sections-in-surgical-decision-making-for-acute-invasive-fungal-rhinosinusitis
#13
Peter Papagiannopoulos, Diana Murro Lin, Samer Al-Khudari, Kumar Rajan, Swathi Reddy, Paulo Gattuso, Bobby Tajudeen, Pete S Batra
BACKGROUND: Acute invasive fungal rhinosinusitis (AIFRS) represents a fulminant, potentially fatal, disease process in immunocompromised patients. The diagnosis often rests on high index of clinical suspicion, with relative paucity of data on the diagnostic and therapeutic implications of intraoperative frozen sections. METHODS: Retrospective review was performed for 18 cases undergoing endoscopic sinus surgery for AIFRS. Reliability of intraoperative frozen section diagnosis was evaluated for all patients using final pathology as the gold standard...
February 9, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28182331/establishing-utility-values-for-the-22-item-sino-nasal-outcome-test-snot-22-using-a-crosswalk-to-the-euroqol-five-dimensional-questionnaire-three-level-version-eq-5d-3l
#14
R Trafford Crump, Ernest Lai, Guiping Liu, Arif Janjua, Jason M Sutherland
BACKGROUND: Chronic rhinosinusitis (CRS) is a common condition for which there are numerous medical and surgical treatments. The 22-item Sino-Nasal Outcome Test (SNOT-22) is a patient-reported outcome measure often used with patients diagnosed with CRS. However, there are no utility values associated with the SNOT-22, limiting its use in comparative effectiveness research. The purpose of this study was to establish utilities for the SNOT-22 by mapping responses to utility values associated with the EuroQol-5-dimensional questionnaire-3-level version (EQ-5D-3L)...
February 9, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28182329/perceived-compliance-and-barriers-to-care-in-sublingual-immunotherapy
#15
Manvinder S Kumar, Melissa S Oh, Brittany Leader, Melissa Rotella, Leisa Stillman, John M DelGaudio, Sarah K Wise
BACKGROUND: For allergy immunotherapy to be effective, patient compliance is critical. However, aqueous sublingual immunotherapy (SLIT) may be considered demanding for patients, requiring strict daily dosing and refilling of medication at regular intervals. In this study we sought to determine how patients perceive their own compliance with SLIT and identify barriers that may hinder compliance. METHODS: Using a retrospective review, 46 patients currently undergoing aqueous SLIT were identified to have less-than-excellent compliance based on frequency of clinic visits for SLIT refills...
February 9, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28151588/safety-of-long-term-intranasal-budesonide-delivered-via-the-mucosal-atomization-device-for-chronic-rhinosinusitis
#16
Jamil Manji, Gurkaran Singh, Christopher Okpaleke, Anali Dadgostar, Fahad Al-Asousi, Ameen Amanian, Luis Macias-Valle, Andres Finkelstein, Mark Tacey, Andrew Thamboo, Amin Javer
BACKGROUND: Although short-term use (≤2 months) of atomized topical nasal steroids has been shown to be safe and effective, the long-term safety has yet to be demonstrated. The aim of this study was to determine the impact of long-term topical budesonide treatment via the mucosal atomization device (MAD) on the hypothalamic-pituitary-adrenal axis (HPAA) and intraocular pressure (IOP). METHODS: A cross-sectional study of patients with chronic rhinosinusitis (CRS), with or without nasal polyposis, managed with daily nasal budesonide via MAD was conducted at a tertiary rhinology center...
February 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28151587/nonadherence-to-sublingual-immunotherapy-in-allergic-rhinitis-a-real-life-analysis
#17
Ting Wang, Yue Li, Feng Wang, Chengyong Zhou
BACKGROUND: To sustain the long-lasting beneficial effects of allergen-specific sublingual immunotherapy (SLIT), an adequate duration of treatment is required. Nevertheless, many patients discontinue prematurely and therefore fail to obtain satisfactory therapeutic effect in clinical practice. The aim of this study was to analyze the causes leading to premature discontinuation of SLIT in allergic rhinitis (AR), and to provide the corresponding countermeasures for the following SLIT course...
February 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28151586/nuclear-erythroid-2-related-factor-2-activation-inhibits-house-dust-mite-induced-sinonasal-epithelial-cell-barrier-dysfunction
#18
Nyall R London, Anuj Tharakan, Andrew P Lane, Shyam Biswal, Murugappan Ramanathan
BACKGROUND: Dysregulated sinonasal epithelial cell (SNEC) barrier function has been proposed to contribute to the pathogenesis of sinonasal inflammatory conditions such as allergic rhinitis (AR) and chronic rhinosinusitis (CRS). Allergens such as house dust mite (HDM) have been reported to disrupt SNEC barrier integrity. We have recently identified nuclear erythroid 2-related factor 2 (Nrf2) activation via sulforaphane (SFN) stimulation to stabilize SNEC barrier function. The purpose of this study was to explore whether Nrf2 activation could ameliorate HDM-induced SNEC barrier dysfunction...
February 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28117948/bactericidal-antibiotics-promote-oxidative-damage-and-programmed-cell-death-in-sinonasal-epithelial-cells
#19
Michael A Kohanski, Anuj Tharakan, Nyall R London, Andrew P Lane, Murugappan Ramanathan
BACKGROUND: Antibiotics are widely and heavily used in the treatment of chronic sinusitis. Bactericidal antibiotics can stimulate reactive oxygen species (ROS) formation, a proinflammatory response, and cell death in cultured human sinonasal epithelial cells (SNECs). Sulforaphane (SFN) is a potent stimulator of the antioxidant nuclear factor erythroid 2-related factor 2 (Nrf-2) system and a suppressor of inflammation. In this study we utilized SFN to further explore the relationship between levofloxacin treatment, ROS formation, and the cell death response...
January 24, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28092140/a-systematic-review-of-sinonasal-oncocytomas-and-oncocytic-carcinomas-diagnosis-management-and-technical-considerations
#20
REVIEW
Zerina Hodzic, Nicholas R Rowan, Ryota Kashiwazaki, Thomas J Willson, Eric W Wang, Stella E Lee
BACKGROUND: Oncocytomas and oncocytic carcinomas are rare tumors of the sinonasal cavity with the propensity for local invasion. This report and systematic review details a case of a nasal oncocytoma involving the lacrimal sac and provides an update of the current literature. METHODS: A systematic literature review was performed using PubMed and Ovid databases. The data obtained from published articles with sinonasal oncocytoma/oncocytic carcinoma as the primary diagnosis included patient demographics, presentation, radiographic and histologic findings, management, and recurrence rates...
January 16, 2017: International Forum of Allergy & Rhinology
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