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International Forum of Allergy & Rhinology

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https://www.readbyqxmd.com/read/29461689/clinical-associations-between-allergies-and-rapid-eye-movement-sleep-disturbances
#1
Shelley R Berson, Jaclyn Klimczak, Elizabeth A Prezio, Shirley Hu, Manoj Abraham
BACKGROUND: Allergic rhinitis, an immunoglobulin E inflammatory condition including nasal congestion, obstruction, sneezing, pruritus, and fatigue symptoms, has significant impact on quality of life and impairs sleep. Sleep-disordered breathing (SDB) patients often have normal all-night apnea-hypopnea (AHI) or respiratory-disturbance (RDI) indices on polysomnography (PSG). We hypothesized that the rapid eye motion-respiratory disturbance index (REM-RDI) may be a novel predictor of allergic status...
February 20, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29457874/computed-tomography-analysis-of-frontal-cell-prevalence-according-to-the-international-frontal-sinus-anatomy-classification
#2
Garret Choby, Andrew Thamboo, Tae-Bin Won, Jooyeon Kim, Liang Chun Shih, Peter H Hwang
BACKGROUND: The International Frontal Sinus Anatomy Classification (IFAC) is an international consensus document published in 2016 to standardize the nomenclature of cells in the region of the frontal recess and frontal sinus. The IFAC was designed to be surgically relevant and anatomically precise. The current study was undertaken to assess the prevalence of the frontal cell variants as defined by the IFAC, as well as to determine the interrater reliability of the IFAC. METHODS: Three independent reviewers examined triplanar nondiseased maxillofacial computed tomography (CT) scans to assess the anatomy of the frontal recess according to the IFAC system...
February 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29457873/the-impact-of-video-nasal-endoscopy-on-patient-satisfaction
#3
Vidur Bhalla, D David Beahm, Kevin J Sykes, Kavindu K Ndeti, Alexander G Chiu
BACKGROUND: Video nasal endoscopy has significant associated expense for practices, but its use has been justified by the benefit it provides to the examiner. No study has examined the perceived benefit to the patient. In this study, the impact of video endoscopy on patient satisfaction is evaluated. METHODS: A prospective, randomized, single-blinded study was performed on new patients receiving care in the rhinology clinics of a tertiary-care center. Patients were randomized into the standard endoscopic examination (SEE) or video endoscopic examination (VEE) groups...
February 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29446869/dimensions-of-the-medial-wall-of-the-prelacrimal-recess
#4
Khaled Kashlan, John Craig
BACKGROUND: Addressing anterior maxillary sinus pathology endoscopically that is inaccessible with an endoscopic modified medial maxillectomy requires either a prelacrimal approach (PLA) or an endoscopic Denker's approach (EDA). The PLA involves removing the medial wall of the prelacrimal recess (PLR), which is the bone between the pyriform aperture (PA) and nasolacrimal duct (NLD), from nasal floor to orbital floor. The PLA preserves the inferior turbinate and NLD, whereas both are sacrificed during an EDA...
February 15, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29443458/the-functional-and-psychological-burden-of-empty-nose-syndrome
#5
Jamil Manji, Jayakar V Nayak, Andrew Thamboo
BACKGROUND: Empty nose syndrome (ENS) is a debilitating disorder thought to arise as a postsurgical phenomenon from excessive loss of nasal tissues. Affected patients often report a profound impact on all aspects of life, but the extent of this burden has not been quantified. We sought to determine the association of ENS with mental health and functional impairments. METHODS: A cross-sectional study was performed of individuals with ENS recruited from online ENS forums...
February 14, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29437297/snot-22-based-clusters-in-chronic-rhinosinusitis-without-nasal-polyposis-exhibit-distinct-endotypic-and-prognostic-differences
#6
Devyani Lal, Claire Hopkins, Rohit D Divekar
BACKGROUND: Endotypic and prognosticating features of chronic rhinosinusitis without nasal polyposis (CRSsNP) are poorly understood. Our objectives were to use an unbiased symptom-based approach to: (1) study symptoms, clinical and endotypic features; and (2) identify features predicating outcomes from endoscopic sinus surgery (ESS). METHODS: Clinical, computed tomography (CT), histopathology, and 22-item Sino-Nasal Outcome Test (SNOT-22) data was collected on 146 adult CRSsNP patients who underwent ESS...
February 13, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29424124/can-a-postnasal-drip-can-be-aspirated-into-the-lungs
#7
EDITORIAL
Peter-John Wormald
No abstract text is available yet for this article.
February 9, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29412515/l-methionine-anti-biofilm-activity-against-pseudomonas-aeruginosa-is-enhanced-by-the-cystic-fibrosis-transmembrane-conductance-regulator-potentiator-ivacaftor
#8
Do-Yeon Cho, Dong-Jin Lim, Calvin Mackey, Christopher G Weeks, Jaime A Peña Garcia, Daniel Skinner, Jessica W Grayson, Harrison S Hill, David K Alexander, Shaoyan Zhang, Bradford A Woodworth
BACKGROUND: Biofilms may contribute to refractory chronic rhinosinusitis (CRS), as they lead to antibiotic resistance and failure of effective clinical treatment. l-Methionine is an amino acid with reported biofilm-inhibiting properties. Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator with mild antimicrobial activity via inhibition of bacterial DNA gyrase and topoisomerase IV. The objective of this study was to evaluate whether co-treatment with ivacaftor and l-methionine can reduce the formation of Pseudomonas aeruginosa biofilms...
February 7, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29412510/otolaryngologist-adherence-to-the-aao-hnsf-allergic-rhinitis-clinical-practice-guideline
#9
Adam Honeybrook, Matthew Ellison, Liana Puscas, Eileen Raynor
BACKGROUND: In February 2015, the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNSF) published the Allergic Rhinitis Clinical Practice Guideline (AR-CPG). The objective of this study was to assess otolaryngologists' perception of the accuracy and adherence to the AR-CPG. METHODS: A survey was distributed to fellows of the American Academy of Otolaryngic Allergy and members of the American Academy of Otolaryngology-Head and Neck Surgery Foundation...
February 7, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29394004/corticosteroid-nasal-irrigations-are-more-effective-than-simple-sprays-in-a-randomized-double-blinded-placebo-controlled-trial-for-chronic-rhinosinusitis-after-sinus-surgery
#10
Richard J Harvey, Kornkiat Snidvongs, Larry H Kalish, Gretchen M Oakley, Raymond Sacks
BACKGROUND: Persistent mucosal inflammation in patients with chronic rhinosinusitis (CRS) often results in ongoing symptoms, recurrence of polypoid mucosa, infective exacerbations, and further systemic medication despite surgical intervention. Debate exists as to the most effective topical therapy in CRS. METHODS: The objective was to determine if corticosteroid delivered via a nasal irrigation or via a simple nasal spray would be more effective in controlling the symptoms and signs of CRS...
February 2, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29394000/influence-of-the-location-of-nasal-polyps-on-olfactory-airflow-and-olfaction
#11
Hironobu Nishijima, Kenji Kondo, Takahisa Yamamoto, Tsutomu Nomura, Shu Kikuta, Yuya Shimizu, Yu Mizushima, Tatsuya Yamasoba
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) often results in decreased olfaction. In this study, we examined the relationship between nasal polyp location and olfactory airflow and odorant transport changes using virtual nasal polyp models at different locations and computational fluid dynamics (CFD) analysis. We also compared olfactory airflow and olfaction between patients with nasal polyps at different locations using CFD analysis and an olfactory test. METHODS: Nasal computed tomography images were used to generate a normal model and 4 virtual nasal polyp models based on polyp locations, including the olfactory region (all-olfactory model), the region anterior to the olfactory region (preolfactory model), the middle meatus (middle-meatus model), and the superior meatus (superior-meatus model)...
February 2, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29393992/medical-treatment-of-epistaxis-in-hereditary-hemorrhagic-telangiectasia-an-evidence-based-review
#12
Ashleigh A Halderman, Matthew W Ryan, Christopher Clark, Raj Sindwani, Douglas D Reh, David M Poetker, Rosangela Invernizzi, Bradley F Marple
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant hereditary disorder resulting in vascular dysplasia and formation of arteriovenous malformations. Recurrent epistaxis is a hallmark of the disease. An array of medical therapies are used in this patient population, but robust evidence-based recommendations regarding the medical treatment of epistaxis are lacking. This systematic review was performed to look at the current literature and make meaningful evidence-based recommendations...
February 2, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29381260/risk-of-second-primary-malignancy-in-patients-with-sinonasal-tumors-a-population-based-cohort-study
#13
Ashwin Ganti, Max A Plitt, Edward C Kuan, Hannah N Kuhar, Pete S Batra, Bobby A Tajudeen
BACKGROUND: The 5-year overall survival rate for patients with sinonasal cancers has remained around 50% for the last 3 decades. Prior studies on head and neck cancers have suggested that 1 reason for poor survival is the frequent development of second primary malignancies (SPMs). The purpose of this study is to assess overall and site-specific risks of SPM following treatment of sinonasal malignancy. METHODS: A retrospective, population-based cohort study was performed on 2614 patients in the Surveillance, Epidemiology, and End Results (SEER) database who were diagnosed with primary sinonasal malignancy between 1973 and 2014...
January 30, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29381259/nasal-valve-evaluation-in-the-mexican-hispanic-mestizo-nose
#14
Elizabeth Jasso-Ramírez, Fernando Sánchez Y Béjar, Fernando Arcaute Aizpuru, Irene E Maulen Radován, Héctor de la Garza Hesles
BACKGROUND: Our aim in this study was to determine the angle of the internal nasal valve in Mexican patients with the "mestizo nose" feature and without nasal obstructive symptoms. The work was prospective, comparative, and observational in nature and included patients >14 years of age who were seen in the Otolaryngology Department at the Los Angeles Lomas Hospital between April and May 2016. METHODS: The angle of the internal nasal valve was measured in 30 patients without obstructive symptoms...
January 30, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29381255/airborne-and-food-sensitization-patterns-in-children-and-adults-with-eosinophilic-esophagitis
#15
Yu Ting He, Paul J Christos, William R Reisacher
BACKGROUND: The pathogenesis of eosinophilic esophagitis (EoE) is currently unknown, but evidence suggests that allergic sensitization to food and airborne allergens may play a key role. This retrospective study examines the rate of sensitization to both food and airborne allergens in EoE patients, and compares their sensitivity patterns to control groups. METHODS: We identified 103 patients with a diagnosis of EoE via esophageal eosinophilia (≥15 eosinophils/high-power field [hpf]), who had undergone comprehensive food and/or airborne allergen testing through either skin or in vitro methods...
January 30, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29377605/single-vs-multiallergen-sublingual-immunotherapy-in-the-polysensitized-patient-a-pilot-study
#16
Alexandra Shams Ortiz, K Christopher McMains, Adrienne M Laury
BACKGROUND: Sublingual immunotherapy (SLIT) has emerged as an effective and exceptionally safe method of treatment of the atopic patient. However, the optimal number of allergens that should be included in the SLIT treatment regimen for the polysensitized patient is not known and practices vary widely. This study aims to compare the efficacy of single-allergen SLIT with pauci-allergen vs multiallergen aqueous SLIT in polysensitized patients. METHODS: Sixteen subjects sensitized to 6+ allergens were enrolled in the study...
January 29, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29360225/olfactory-dysfunction-and-cognition-among-older-adults-in-the-united-states
#17
Janet S Choi, Kevin Hur, Michael Chow, Jasper Shen, Bozena Wrobel
BACKGROUND: In this work we assess the association between olfactory dysfunction and cognition in a nationally representative sample of older adults in the United States. METHODS: Participants aged ≥60 years (n = 1236) from the 2013-2014 National Health and Nutritional Examination Survey underwent both olfactory and cognitive testing. Olfaction was assessed by both objective test (8-odor Pocket Smell Test: smell impairment defined as score ≤2) and self-report...
January 23, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29350840/a-phase-3-trial-of-mometasone-furoate-sinus-implants-for-chronic-sinusitis-with-recurrent-nasal-polyps
#18
Robert C Kern, J Pablo Stolovitzky, Stacey L Silvers, Ameet Singh, Jivianne T Lee, David M Yen, Alfred M C Iloreta, Francis P J Langford, Boris Karanfilov, Keith E Matheny, James W Stambaugh, Anna K Gawlicka
BACKGROUND: Topical intranasal corticosteroid sprays (INCSs) are standard treatment for nasal polyps (NPs), but their efficacy is reduced by poor patient compliance and impaired access of drug to the sinus mucosa. A corticosteroid-eluting sinus implant was designed to address these limitations in patients with recurrent polyposis after sinus surgery by delivering 1350 μg of mometasone furoate (MF) directly to the ethmoid sinus mucosa over approximately 90 days. METHODS: A randomized, sham-controlled, double-blind trial was undertaken in 300 adults with refractory chronic rhinosinusitis with NPs (CRSwNP), who were candidates for repeat surgery...
January 19, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29341484/nasal-ventilation-is-an-important-factor-in-evaluating-the-diagnostic-value-of-nasal-nitric-oxide-in-allergic-rhinitis
#19
Jing Hou, Hongfei Lou, Yang Wang, Fei He, Feifei Cao, Chengshuo Wang, Luo Zhang
BACKGROUND: The role of nasal nitric oxide (NO) in the diagnosis of allergic rhinitis (AR) is controversial. The aim of this study was to identify factors that may affect levels of nasal NO in AR patients and evaluate the role of nasal NO in the diagnosis of AR. METHODS: Seventy-five AR patients and 31 healthy controls were enrolled in this study. AR symptom scores were assessed using the visual analog scale. Eosinophil cationic protein (ECP) was detected by enzyme-linked immunoassay, nasal NO was measured using a chemiluminescence analyzer, and nasal airway resistance (NAR) was assessed by active anterior rhinomanometry...
January 17, 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29341450/characterization-of-a-novel-papain-inducible-murine-model-of-eosinophilic-rhinosinusitis
#20
Anuj Tharakan, Alex Dobzanski, Nyall R London, Syed M Khalil, Nitya Surya, Andrew P Lane, Murugappan Ramanathan
BACKGROUND: Eosinophilic chronic rhinosinusitis (ECRS) is a disease characterized by eosinophilic inflammatory infiltrate and a local type 2 cytokine milieu. Current animal models fail to recapitulate many of the innate and adaptive immunologic hallmarks of the disease, thus hindering the development of effective therapeutics. In the present study, mice were exposed intranasally to the cysteine protease papain, which shares functional similarities with parasitic proteases and aeroallergens, to generate a rapidly inducible murine model of eosinophilic rhinosinusitis...
January 17, 2018: International Forum of Allergy & Rhinology
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