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International Forum of Allergy & Rhinology

Joseph D Hunt, Evan R Reiter, Richard M Costanzo
BACKGROUND: Taste complaints are commonly encountered in clinical practice. Although changes in taste function may arise from varied etiologies, numerous other factors may impact patients' taste perceptions, the most common of which is olfactory dysfunction. Thus, patients with taste complaints may or may not have measurable deficits in taste function. This poses a challenge to providers faced with evaluation of patients with taste disorders, and may delay diagnosis and management. METHODS: We retrospectively examined records of 1108 patients evaluated at the Virginia Commonwealth University Health System Smell and Taste Clinic and compared patients' subjective taste complaints with results of objective testing of the senses of taste and smell...
December 10, 2018: International Forum of Allergy & Rhinology
Jonathan Yip, Weibo Hao, Antoine Eskander, John M Lee
BACKGROUND: Previous studies on the impact of wait times for endoscopic sinus surgery (ESS) in medically recalcitrant chronic rhinosinusitis (rCRS) have not examined its influence on the 5 distinct symptoms domains of the 22-item Sino-Nasal Outcome Test (SNOT-22), and have not applied evidence-based surgical indications. Our primary study objective was to investigate the impact of ESS wait times on postoperative SNOT-22 global and symptom domain scores in patients with rCRS deemed "appropriate" surgical candidates...
December 10, 2018: International Forum of Allergy & Rhinology
Timothy L Smith
No abstract text is available yet for this article.
December 3, 2018: International Forum of Allergy & Rhinology
Charles A Riley, Matthew Kim, Anthony P Sclafani, Aron Kallush, Klaus Kjaer, Ashutosh S Kacker, Abtin Tabaee
BACKGROUND: Opioid-based analgesics are routinely prescribed after elective rhinologic surgery. Balancing appropriate pain management while avoiding overprescription necessitates an evidence-based approach. METHODS: Patients undergoing elective rhinologic surgery, including endoscopic sinus surgery (ESS), septoplasty, or ESS with septoplasty, were prospectively enrolled. Patients completed demographic and psychometric questionnaires assessing attitudes toward pain, baseline anxiety, and depression before surgery...
December 3, 2018: International Forum of Allergy & Rhinology
Weiqing Wang, Yali Gao, Zhenzhen Zhu, Yang Zha, Xiaowei Wang, Fang Qi, Liangrui Zhou, Junyi Pang, Zhiqiang Gao, Wei Lv
BACKGROUND: Traditionally, it was believed that chronic rhinosinusitis with nasal polyps (CRSwNP) demonstrated less eosinophilic and more neutrophilic inflammation in China compared to North America and Europe. However, inflammatory patterns may change over time. The study aimed to analyze the changing trends in the clinical and histological characteristics of CRSwNP over time in China. METHODS: A total of 115 consecutive CRSwNP patients from 2003 to 2005 and 114 consecutive CRSwNP patients from 2014 to 2016 were enrolled in this retrospective study...
November 29, 2018: International Forum of Allergy & Rhinology
Guillermo Maza, Chengyu Li, Jillian P Krebs, Bradley A Otto, Alexander A Farag, Ricardo L Carrau, Kai Zhao
BACKGROUND: Empty nose syndrome (ENS) is a rare and debilitating disease with a controversial definition, etiology, and treatment. One puzzling fact is that patients who undergo an endoscopic endonasal approach (EEA) often have resection of multiple anatomic structures, yet seldom develop ENS. In this pilot study, we analyzed and compared the computational fluid dynamics (CFD) and symptoms among post-EEA patients, ENS patients, and healthy subjects. METHODS: Computed tomography scans of 4 post-EEA patients were collected and analyzed using CFD techniques...
November 29, 2018: International Forum of Allergy & Rhinology
Edward D McCoul, Scott I Mayer, Abtin Tabaee, Jeffrey C Bedrosian, Michael J Marino
BACKGROUND: Signs of inflammation are commonly encountered during endoscopic examination of the Eustachian tube (ET) region. The clinical applicability of these findings may be enhanced by use of a standardized assessment score. METHODS: Digital video recordings were obtained of 50 nasal endoscopy examinations of the nasopharyngeal portion of the ET. Four fellowship-trained rhinologists independently reviewed the videos with regard to specific physical findings: edema of the ET torus, erythema of the ET torus, exudate at the ET orifice, and presence of tubal tonsil...
November 28, 2018: International Forum of Allergy & Rhinology
Justin C Morse, Meghan H Shilts, Kim A Ely, Ping Li, Quanhu Sheng, Li-Ching Huang, Todd J Wannemuehler, Naweed I Chowdhury, Rakesh K Chandra, Suman R Das, Justin H Turner
BACKGROUND: Olfactory dysfunction is a common symptom of chronic rhinosinusitis (CRS). We previously identified several cytokines potentially linked to smell loss, potentially supporting an inflammatory etiology for CRS-associated olfactory dysfunction. In the current study we sought to validate patterns of olfactory dysfunction in CRS using hierarchical cluster analysis, machine learning algorithms, and multivariate regression. METHODS: CRS patients undergoing functional endoscopic sinus surgery were administered the Smell Identification Test (SIT) preoperatively...
November 28, 2018: International Forum of Allergy & Rhinology
Nicholas R Rowan, Zachary M Soler, Kristina A Storck, Florence Othieno, Kimia G Ganjaei, Timothy L Smith, Rodney J Schlosser
BACKGROUND: Despite the tremendous burden of smell and taste dysfunction in patients with chronic rhinosinusitis (CRS), objective measures of smell and taste fail to fully account for eating-related disruptions in CRS patient quality of life (QOL). In this study we sought to investigate the driving force behind impaired eating-related QOL in CRS patients. METHODS: Adult CRS patients were prospectively enrolled and answered a series of surveys relating to smell, taste, overall sinus-specific QOL, and depression...
November 28, 2018: International Forum of Allergy & Rhinology
Sarina K Mueller, Angela L Nocera, Simon T Dillon, Xuesong Gu, Olaf Wendler, Hasan H Otu, Towia A Libermann, Benjamin S Bleier
BACKGROUND: Exosomes are secreted epithelial-derived vesicles that contain a conserved protein array representative of their parent cell. Exosomes may be reproducibly and noninvasively purified from nasal mucus. The exosomal proteome can be quantified using SOMAscanTM , a highly multiplexed, aptamer-based proteomic platform. The purpose of this study was to determine whether chronic rhinosinusitis with nasal polyps (CRSwNP) has a unique predictive exosomal proteomic biosignature. METHODS: Exosomes were isolated from whole mucus sampled from control and CRSwNP patients (n = 20 per group) by differential ultracentrifugation...
November 28, 2018: International Forum of Allergy & Rhinology
Eric H Holbrook, Sidharth V Puram, Reiner B See, Aaron G Tripp, Dinesh G Nair
BACKGROUND: Anosmia has an estimated prevalence of 5% of the general population. Outside of inflammatory causes, therapeutic options are limited despite research advances. Bypassing peripheral neuronal damage through central stimulation is a potential therapeutic option that has shown success in other sensory systems, most notably with hearing. We performed a pilot study to determine the feasibility of inducing smell through artificial electrical stimulation of the olfactory bulbs in humans...
November 27, 2018: International Forum of Allergy & Rhinology
Peng Tian, Huashuang Ou, Fan Wu, Yun Ma, Xiang Liu, Qiujian Chen, Hua Dang, Hua Zou
BACKGROUND: Much attention on the pathophysiology of nasal polyp (NP) has focused on eosinophils. Interleukin (IL)-4 and eotaxin-3 (C-C motif chemokine ligand 26, or CCL26) levels have been reported to be increased in eosinophilic nasal polyps. The aim of this study was to characterize CCL26 posttranscriptional regulation by the RNA-binding protein HuR in primary human nasal polyp-derived epithelial cells (hNPDECs) challenged with IL-4. METHODS: A prospective, observational study was conducted...
November 24, 2018: International Forum of Allergy & Rhinology
Justin McCormick, Do-Yeon Cho, Brooks Lampkin, Joshua Richman, Heather Hathorne, Steven M Rowe, Bradford A Woodworth
BACKGROUND: Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that improves pulmonary function in cystic fibrosis (CF) patients with at least 1 copy of the G551D CFTR mutation. The purpose of this study is to evaluate the impact of ivacaftor on chronic rhinosinusitis (CRS) symptoms in this population. METHODS: The G551D Observational (GOAL) study was a multicenter prospective cohort study enrolling CF patients ≥6 years with at least 1 G551D mutation...
November 24, 2018: International Forum of Allergy & Rhinology
Carol H Yan, Jonathan B Overdevest, Zara M Patel
BACKGROUND: Olfactory loss is a common and debilitating disease with limited treatment options, particularly for olfactory dysfunction not related to sinonasal inflammation. Both topical and systemic steroids have been used as treatments for olfactory loss. This study systematically reviews the literature on the efficacy of steroids for non-chronic rhinosinusitis (CRS)-related olfactory loss and provides recommendations. METHODS: A literature search of PubMed, Ovid, EMBASE, and the Cochrane Database was performed according to Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) guidelines...
November 24, 2018: International Forum of Allergy & Rhinology
Zain H Rizvi, Rocco Ferrandino, Quang Luu, Jeffrey D Suh, Marilene B Wang
BACKGROUND: Transsphenoidal pituitary surgery has evolved into a safe procedure with shorter hospitalizations, yet unplanned readmissions remain a quality measure for which there is a paucity of data. We sought to examine rates, timing, etiologic factors, and costs surrounding readmission after transsphenoidal pituitary surgery. METHODS: The Nationwide Readmissions Database (NRD) was queried for patients who underwent transsphenoidal pituitary between January 2013 and November 2013...
November 23, 2018: International Forum of Allergy & Rhinology
Bassel Bashjawish, Shreya Patel, Suat Kılıç, Peter F Svider, Wayne D Hsueh, James K Liu, Soly Baredes, Jean Anderson Eloy
BACKGROUND: Elderly patients with multiple comorbidities may be at higher risk of postoperative complications. With an increasingly aging population, more data assessing for predisposing factors are needed in this at-risk group. In this study, we analyzed the effect of elderly status on relative comorbidities and complications of sinonasal cancer (SNC) patients receiving surgery. METHODS: A retrospective database analysis was performed using cases from the Nationwide Inpatient Sample (NIS) from 2003 to 2012...
November 23, 2018: International Forum of Allergy & Rhinology
Ashley Sikand, Dale R Ehmer, J Pablo Stolovitzky, Chad M McDuffie, Neelesh Mehendale, Ford D Albritton
BACKGROUND: A limited number of studies have demonstrated symptomatic improvement for recurrent acute rhinosinusitis (RARS) patients after endoscopic sinus surgery. In this randomized, controlled study we evaluated 24-week outcomes for balloon sinus dilation (BSD) performed in-office (IO) with medical management (MM) as compared with MM only for RARS patients. METHODS: Adults diagnosed with RARS were randomized to groups with BSD plus MM (n = 29) or MM alone (n = 30)...
November 19, 2018: International Forum of Allergy & Rhinology
Tingjie Liu, Yurong Gu, Kaizheng Chen, Xia Shen
BACKGROUND: For sinus surgery, some centers favor total intravenous anesthesia (TIVA) over inhalation anesthesia. However, whether TIVA affects the patient's perceived quality of recovery remains unclear. This study used the Quality of Recovery-40 questionnaire (QoR-40) to compare patient recovery between surgical patients who received TIVA and those who received desflurane (DES) anesthesia. METHODS: Eighty patients (20 to 65 years old) undergoing endoscopic sinus surgery were prospectively enrolled and randomized to either the TIVA (propofol and remifentanil infusion) or DES (desflurane inhalation and remifentanil infusion) group...
November 19, 2018: International Forum of Allergy & Rhinology
Bing Yan, Yang Wang, Ying Li, Chengshuo Wang, Luo Zhang
BACKGROUND: The epithelial-mesenchymal transition (EMT) is a distinguishing characteristic of chronic rhinosinusitis with nasal polyps (CRSwNP). The underlying mechanism remains largely unknown. Arachidonate 15-lipoxygenase (ALOX15), an enzyme involved in arachidonic acid metabolism, has been reported to cause airway epithelial injury and thus may further promote the EMT. The aim of this study was to evaluate the role of ALOX15 during the EMT process in CRSwNP. METHODS: A total of 54 samples were obtained, including 10 from healthy control, 16 from non-eosinophilic CRSwNP, and 28 from eosinophilic CRSwNP...
November 19, 2018: International Forum of Allergy & Rhinology
Christopher R Roxbury, Janki Shah, Dennis Tang, Varun R Kshettry, Pablo F Recinos, Troy D Woodard, Mark Taylor, Raj Sindwani
BACKGROUND: Late cancellations within 24 hours of surgery lead to decreased utilization of operating room time with loss of productivity, decreased access to care, and inconvenience to patients and staff. To date, no studies have analyzed 24-hour cancellations in a tertiary rhinology practice. METHODS: All procedures performed at a tertiary rhinology/skull base practice from January 2016 to December 2017 were reviewed. Twenty-four-hour cancellations were analyzed by procedure type and reason for cancellation...
November 15, 2018: International Forum of Allergy & Rhinology
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