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International Forum of Allergy & Rhinology

Naweed I Chowdhury, Timothy L Smith, Rakesh K Chandra, Justin H Turner
BACKGROUND: Convolutional neural networks (CNNs) are advanced artificial intelligence algorithms well suited to image classification tasks with variable features. These have been used to great effect in various real-world applications including handwriting recognition, face detection, image search, and fraud prevention. We sought to retrain a robust CNN with coronal computed tomography (CT) images to classify osteomeatal complex (OMC) occlusion and assess the performance of this technology with rhinologic data...
August 11, 2018: International Forum of Allergy & Rhinology
Sarina K Mueller, Angela L Nocera, Simon T Dillon, Dawei Wu, Towia A Libermann, Benjamin S Bleier
BACKGROUND: The coagulation pathway has been previously implicated in the etiopathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) through analysis of individual proteins within the cascade. The purpose of this study was to: (1) apply a large-scale proteomic approach to confirm these previous findings; and (2) correlate the protein aberrations between tissue and exosomes to establish exosomal proteomics as a method to probe the pathophysiology of CRSwNP. METHODS: This investigation was an internal review board-approved study in which matched tissue and mucus exosomal proteomes were compared between control and CRSwNP (n = 10/group) using an aptamer-based proteomic array and confirmed using whole transcriptome sequencing...
August 9, 2018: International Forum of Allergy & Rhinology
Tobial McHugh, Kornkiat Snidvongs, Michael Xie, Sarfaraz Banglawala, Doron Sommer
BACKGROUND: Patients with eosinophilic chronic rhinosinusitis (ECRS) have been shown to have greater disease severity and poorer treatment outcomes after sinus surgery. Although the inflammatory pattern of ECRS is essential to diagnosing this subtype, there is currently no consensus for diagnosis. Our aim in this study was to determine whether high tissue eosinophilia (HTE), measured as eosinophils per high-power field (eos/HPF), could be used to define ECRS based on likelihood of recurrence...
August 9, 2018: International Forum of Allergy & Rhinology
Nyall R London, Masaru Ishii, Gary Gallia, Kofi D O Boahene
BACKGROUND: Reconstruction of the clivus and posterior cranial base defects following endoscopic skull-base surgery can be particularly challenging. Commonly, defects in this region are repaired with pedicled mucoperichondrial flaps from the sinonasal cavity. Complex and large defects often require regional or free flaps, particularly when intranasal flaps have been exhausted. While there are no primary barriers to routing flaps into the clivus or nasopharynx in large open approaches, secondary surgical corridors are necessary during endoscopic cases for routing of free flaps...
August 2, 2018: International Forum of Allergy & Rhinology
Likhit Khattiyawittayakun, Kachorn Seresirikachorn, Wirach Chitsuthipakorn, Dichapong Kanjanawasee, Kornkiat Snidvongs
BACKGROUND: Intranasal corticosteroid (INCS) is the most efficacious medicine for treating chronic rhinitis. A decongestant and INCS combination (INCS-D) is considered for nasal congestion that is not improved by INCS. This study aimed to investigate the effects of INCS-D on chronic rhinitis. METHODS: Literature searches were performed using MEDLINE and EMBASE. Randomized controlled trials studying the effects of INCS-D vs INCS alone for treating chronic rhinitis were included...
July 28, 2018: International Forum of Allergy & Rhinology
Daniel M Beswick, Jess C Mace, Luke Rudmik, Zachary M Soler, Adam S DeConde, Timothy L Smith
BACKGROUND: Chronic rhinosinusitis (CRS) is associated with substantial productivity losses. Prior cross-sectional study has identified risk factors and symptom subdomains contributing to baseline productivity loss. This study evaluates correlations between posttreatment changes in symptom subdomain and productivity loss. METHODS: A total of 202 adult patients with refractory CRS were prospectively enrolled into an observational, multi-institutional cohort study between August 2012 and June 2015...
July 28, 2018: International Forum of Allergy & Rhinology
Yongshi Yang, Yin Wang, Lin Yang, Jingru Wang, Nan Huang, Xiaolong Wang, Lintao Hu, Qing Jiang, Guanghui Liu, Rongfei Zhu
BACKGROUND: Allergen immunotherapy (AIT) is still the only causal treatment for allergic diseases. However, conventional subcutaneous immunotherapy (SCIT) administration schedules are time-consuming and patient nonadherence is a major barrier to achieving a satisfactory therapeutic effect. Our study aimed to analyze the causes leading to discontinuation of SCIT and to determine risk factors associated with nonadherence in respiratory allergies. METHODS: This was a prospective study...
July 26, 2018: International Forum of Allergy & Rhinology
Waleed M Abuzeid, Vallerinteavide Mavelli Girish, Judd H Fastenberg, Andrew R Draganski, Andrew Y Lee, Joshua D Nosanchuk, Joel M Friedman
BACKGROUND: Bacteria, particularly in the biofilm state, may be implicated in the pathogenesis of chronic rhinosinusitis (CRS) and enhance antibiotic resistance. Nitric oxide (NO) is a gaseous immunomodulator with antimicrobial activity and a short half-life, complicating achievement of therapeutic concentrations. We hypothesized that a novel microparticle-based delivery platform, which allows for adjustable release of NO, could exhibit potent antibacterial effects. METHODS: Porous organosilica microparticles (SNO-MP) containing nitrosylated thiol groups were formulated...
July 25, 2018: International Forum of Allergy & Rhinology
Woo Ri Choi, Hyeon-Yeong Jeong, Ji Heui Kim
BACKGROUND: The Questionnaire of Olfactory Disorders (QOD) is a self-report questionnaire that provides subjective information about olfactory dysfunction. The QOD is widely used in clinical practice because of its high level of reliability and efficacy in Western countries. In this study we evaluated the reliability and validity of the Korean version of the QOD. METHODS: A total of 213 patients with subjective olfactory dysfunction completed 2 different surveys (the QOD and the 36-item Short-Form Health Survey [SF-36])...
July 24, 2018: International Forum of Allergy & Rhinology
David W Kennedy
No abstract text is available yet for this article.
July 20, 2018: International Forum of Allergy & Rhinology
Elizabeth D Stephenson, Zainab Farzal, Adam M Zanation, Brent A Senior
BACKGROUND: Analysis of general surgery literature has revealed noteworthy sex bias and underreporting. Our objective was to determine the prevalence of sex bias and underreporting in rhinology. METHODS: All articles in 2016 issues of Rhinology, the American Journal of Rhinology and Allergy (AJRA), and the International Forum of Allergy and Rhinology (IFAR) were reviewed. Of 369 articles, 248 met inclusion criteria. Excluded studies were cadaveric, meta-analysis/review, and editorial...
July 20, 2018: International Forum of Allergy & Rhinology
Mingyang L Gray, Caleb J Fan, Catharine Kappauf, Sarah Kidwai, Patrick Colley, Alfred Marc Iloreta, Satish Govindaraj
BACKGROUND: Postoperative pain management is controversial as there are no current guidelines to direct clinical practice. The purpose of this study was to demonstrate prescribing patterns for pain management after functional endoscopic sinus surgery (FESS). METHODS: A 15-item web-based survey was electronically distributed to 1770 members of the American Rhinologic Society (ARS). Linear regression analysis was used to determine associations between providers and prescribing patterns...
July 18, 2018: International Forum of Allergy & Rhinology
Sean McKee, Anthony Yang, Sarah Kidwai, Satish Govindaraj, Raj Shrivastava, Alfred Iloreta
BACKGROUND: Prolonged length of stay (pLOS), disease-related complications, and 30-day readmissions are important quality metrics under the Affordable Care Act. The purpose of our study was to investigate the effect of patient-level and hospital-level factors on these outcomes for patients admitted for transsphenoidal pituitary surgery. METHODS: The Statewide Planning and Research Cooperative System (SPARCS) database was queried to investigate 30-day readmissions and pLOS for transsphenoidal pituitary surgery in New York from 1995 to 2015...
July 14, 2018: International Forum of Allergy & Rhinology
Jian-Bo Shao, Xiang-Qian Luo, Yong-Jin Wu, Mao-Gang Li, Jing-Yi Hong, Li-Hua Mo, Zhi-Gang Liu, Hua-Bin Li, Da-Bo Liu, Ping-Chang Yang
BACKGROUND: The interleukin (IL)-10 expression in B cells plays an important role in immune tolerance. The regulation of IL-10 expression in B cells is not fully understood yet. Tumor necrosis factor (TNF) is increased in allergic rhinitis (AR) patients. This study tests a hypothesis that TNF enhances histone deacetylase (HDAC)11 expression to inhibit the expression of IL-10 in B cells of AR patients. METHODS: Peripheral B cells were collected from healthy persons and patients with AR...
July 14, 2018: International Forum of Allergy & Rhinology
Renwu Zhao, Zhiqiang Guo, Weiyang Dong, Congrui Deng, Zhijin Han, Jian Liu, Hanwei Wang, Guoshun Zhuang, Ruxin Zhang
BACKGROUND: According to epidemiologic studies, fine particulate matter (particulate matter ≤2.5 μm, PM2.5) is closely associated with increases in the incidence and severity of chronic rhinosinusitis (CRS). However, the role of PM2.5 in the pathophysiology of CRS remains largely unknown. In this study, we investigated the effects of PM2.5 on nasal cilia, tissue remodeling, and mucus hypersecretion in a rabbit model of CRS. METHODS: CRS rabbits were exposed to ambient PM2...
July 12, 2018: International Forum of Allergy & Rhinology
Elif Dağli, Emre Ocak, Emre Mirici, Mesut Kaya, Aydın Acar
BACKGROUND: A randomized, prospective, double-blinded clinical study was conducted at a single, tertiary referral center. The aim of the study was to evaluate the effects of nasal decongestant use in the early postoperative period after septoplasty. METHODS: After septoplasty, patients who met the study inclusion criteria were randomized into 2 groups to receive either physiologic saline irrigation (saline group) or physiologic saline irrigation plus oxymetazoline hydrochloride 0...
July 12, 2018: International Forum of Allergy & Rhinology
Andrew Thamboo, Aakanksha Rathor, Nicole A Borchard, Jayakar V Nayak, Peter H Hwang, Zara M Patel
BACKGROUND: In uncomplicated chronic rhinosinusitis (CRS), a consensus regarding appropriate medical therapy (AMT) before surgical intervention has been published in the form of "appropriateness criteria" for endoscopic sinus surgery (ESS). We sought to determine why tertiary surgeons may deviate from the suggested criteria and evaluated whether those deviations result in change in outcomes. METHODS: Patients with uncomplicated CRS were prospectively enrolled over the course of 1 year...
July 12, 2018: International Forum of Allergy & Rhinology
Justin Cottrell, Jonathan Yip, Yvonne Chan, Christopher J Chin, Ali Damji, John R de Almeida, Martin Desrosiers, Arif Janjua, Shaun Kilty, John M Lee, Kristian I Macdonald, Eric K Meen, Luke Rudmik, Doron D Sommer, Leigh Sowerby, Marc A Tewfik, Allan D Vescan, Ian J Witterick, Erin Wright, Eric Monteiro
BACKGROUND: Chronic rhinosinusitis (CRS) has been identified as a high-priority disease category for quality improvement. To this end, this study aimed to develop CRS-specific quality indicators (QIs) to evaluate diagnosis and management that relieves patient discomfort, improves quality of life, and prevents complications. METHODS: A guideline-based approach, proposed in 2012 by Kötter et al. was used to develop QIs for CRS. Candidate indicators (CIs) were extracted from 3 practice guidelines and 1 international consensus statement on the diagnosis and management of CRS...
July 12, 2018: International Forum of Allergy & Rhinology
Lei Ren, Luo Zhang, Su Duan, Wei Zhang, Yuan Zhang
BACKGROUND: Although nasal congestion is among the most common symptoms in subjects suffering from nasal diseases, relatively few data on normal airflow resistance are available for reference, especially in healthy Chinese subjects. The aim of present study was therefore to objectively measure the normal airflow resistance by rhinomanometry, and calculate mean and standard reference intervals in a cohort of healthy Chinese subjects. METHODS: A total of 1084 participants were recruited in Huairou region in Beijing, China from November to December 2011...
July 11, 2018: International Forum of Allergy & Rhinology
Jordan T Glicksman, Arjun K Parasher, Laurel Doghramji, David Brauer, Jeremy Waldram, Kristen Walters, Jeff Bulva, James N Palmer, Nithin D Adappa, Andrew A White, John V Bosso
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic rhinosinusitis, nasal polyps, asthma, and respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). In addition to sensitivity to aspirin and NSAIDs, the majority of patients with AERD have been reported to have respiratory intolerance associated with the consumption of alcohol. METHODS: A multicenter prospective cohort study was performed...
July 10, 2018: International Forum of Allergy & Rhinology
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