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International Forum of Allergy & Rhinology

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https://www.readbyqxmd.com/read/28719062/immersive-virtual-reality-as-a-teaching-tool-for-neuroanatomy
#1
Katelyn Stepan, Joshua Zeiger, Stephanie Hanchuk, Anthony Del Signore, Raj Shrivastava, Satish Govindaraj, Alfred Iloreta
BACKGROUND: Three-dimensional (3D) computer modeling and interactive virtual reality (VR) simulation are validated teaching techniques used throughout medical disciplines. Little objective data exists supporting its use in teaching clinical anatomy. Learner motivation is thought to limit the rate of utilization of such novel technologies. The purpose of this study is to evaluate the effectiveness, satisfaction, and motivation associated with immersive VR simulation in teaching medical students neuroanatomy...
July 18, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28707818/inhibition-of-fibroblast-growth-factor-receptor-with-azd4547-mitigates-juvenile-nasopharyngeal-angiofibroma
#2
Tran Le, Jacob New, Joel W Jones, Shireen Usman, Sreeya Yalamanchali, Ossama Tawfik, Larry Hoover, Dan E Bruegger, Sufi Mary Thomas
BACKGROUND: Juvenile nasopharyngeal angiofibroma (JNA) is a benign tumor that presents in adolescent males. Although surgical excision is the mainstay of treatment, recurrences complicate treatment. There is a need to develop less invasive approaches for management. JNA tumors are composed of fibroblasts and vascular endothelial cells. We identified fibroblast growth factor receptor (FGFR) and vascular endothelial growth factor (VEGF) expression in JNA-derived fibroblasts. FGFR influences fibroblast proliferation and VEGF is necessary for angiogenesis...
July 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28707807/accuracy-of-computer-assisted-navigation-significant-augmentation-by-facial-recognition-software
#3
Jordan T Glicksman, Christine Reger, Arjun K Parasher, David W Kennedy
BACKGROUND: Over the past 20 years, image guidance navigation has been used with increasing frequency as an adjunct during sinus and skull base surgery. These devices commonly utilize surface registration, where varying pressure of the registration probe and loss of contact with the face during the skin tracing process can lead to registration inaccuracies, and the number of registration points incorporated is necessarily limited. The aim of this study was to evaluate the use of novel facial recognition software for image guidance registration...
July 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28707783/aggressive-necrotizing-pseudomonal-sinonasal-infections
#4
Edward C Kuan, Bobby A Tajudeen, Kevin C Welch, Rakesh K Chandra, Ben J Glasgow, Jeffrey D Suh
BACKGROUND: Pseudomonas aeruginosa is a gram-negative bacterium frequently implicated in recalcitrant sinonasal infections, especially in immunocompromised hosts. We report 6 cases of rapidly progressive pseudomonal acute rhinosinusitis producing tissue necrosis and, in certain cases, cranial nerve palsies. METHODS: Retrospective review of 6 patients with aggressive necrotizing sinonasal infections treated at 4 tertiary academic medical centers with sinonasal cultures growing P...
July 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28665550/industry-relationships-are-associated-with-performing-a-greater-number-of-sinus-balloon-dilation-procedures
#5
Jean Anderson Eloy, Peter F Svider, Michael Bobian, Richard J Harvey, Stacey T Gray, Soly Baredes, Adam J Folbe
BACKGROUND: Industry outreach promotes awareness of novel technologies. However, concerns have been raised that such relationships may also unduly impact medical decision-making. Our objective in this study was to evaluate industry relationships among practitioners who frequently employ balloon dilation (BD), characterizing whether there is any association between financial relationships and BD utilization. METHODS: Provider utilization data (FY-2014) was accessed for individuals billing BD procedures to Medicare, the largest healthcare payor in the United States...
June 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28665549/quality-measurement-for-rhinosinusitis-a-review-from-the-quality-improvement-committee-of-the-american-rhinologic-society
#6
Luke Rudmik, Jose Mattos, John Schneider, Peter R Manes, Janalee K Stokken, Jivianne Lee, Thomas S Higgins, Rodney J Schlosser, Douglas D Reh, Michael Setzen, Zachary M Soler
BACKGROUND: Measuring quality outcomes is an important prerequisite to improve quality of care. Rhinosinusitis represents a high value target to improve quality of care because it has a high prevalence of disease, large economic burden, and large practice variation. In this study we review the current state of quality measurement for management of both acute (ARS) and chronic rhinosinusitis (CRS). METHODS: The major national quality metric repositories and clearinghouses were queried...
June 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28665518/increased-expression-of-tipe2-in-alternatively-activated-macrophages-is-associated-with-eosinophilic-inflammation-and-disease-severity-in-chronic-rhinosinusitis-with-nasal-polyps
#7
Yin Yao, Zhi-Chao Wang, Jin-Xin Liu, Jin Ma, Cai-Ling Chen, Yi-Ke Deng, Bo Liao, Nan Wang, Heng Wang, Qin Ning, Zheng Liu
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multifactorial disorder characterized by exaggerated local immune responses. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is a novel protein with potential immune modulating function. The expression and function of TIPE2 in human airway diseases are unclear. METHODS: The expression of TIPE2 in sinonasal mucosal samples was assessed by means of quantitative reverse transcript-polymerse chain reaction, immunohistochemistry, and Western blotting...
June 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28665504/prognostic-value-of-nasal-cytology-and-clinical-factors-in-nasal-polyps-development-in-patients-at-risk-can-the-beginning-predict-the-end
#8
Eugenio De Corso, Daniela Lucidi, Mariapina Battista, Matteo Romanello, Carla De Vita, Silvia Baroni, Chiara Autilio, Jacopo Galli, Gaetano Paludetti
BACKGROUND: We evaluated the prognostic value of nasal cytology and clinical factors in predicting nasal polyp (NP) development in patients with history of nonallergic chronic sinonasal inflammation. METHODS: This was a retrospective case-control study of 295 patients followed at our institution for a mean of 85.70 ± 19.41 months. According to the inclusion criteria we enrolled 84 cases with persistent eosinophilic nonallergic sinonasal inflammation (group A) and 106 cases with neutrophilic inflammation (group B), both without evidence of NPs at the baseline...
June 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28658539/a-call-for-critical-examination-of-endoscopically-guided-cultures-in-chronic-rhinosinusitis
#9
LETTER
Vijay R Ramakrishnan
No abstract text is available yet for this article.
June 28, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28658531/assessment-of-acquired-mucociliary-clearance-defects-using-micro-optical-coherence-tomography
#10
Kiranya E Tipirneni, Jessica W Grayson, Shaoyan Zhang, Do-Yeon Cho, Daniel F Skinner, Dong-Jin Lim, Calvin Mackey, Guillermo J Tearney, Steven M Rowe, Bradford A Woodworth
BACKGROUND: Dehydration of airway surface liquid (ASL) disrupts normal mucociliary clearance (MCC) in sinonasal epithelium, which may lead to chronic rhinosinusitis (CRS). Abnormal chloride (Cl(-) ) transport is one such mechanism that contributes to this disorder and can be acquired secondary to environmental perturbations, such as hypoxia at the tissue surface. The objective of this study was to assess the technological feasibility of the novel micro-optical coherence tomography (μOCT) imaging technique for investigating acquired MCC defects in cultured human sinonasal epithelial (HSNE) cells...
June 28, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28658522/platelet-activation-by-crushed-and-uncrushed-muscle-a-flow-cytometry-analysis
#11
Alistair Jukes, Dijana Miljkovic, P J Wormald, Alkis J Psaltis
BACKGROUND: Crushed autologous muscle is used in skull base surgery in the acute phase of major arterial hemorrhage to stop bleeding. The mechanism of this is not yet clear, but is thought to involve the formation of a platelet plug, which seals the vessel wall defect but still allows ongoing blood flow to the brain. METHODS: In this study we use flow cytometry to replicate the in-vivo actions of crushed muscle on platelets in whole blood. We compare the ratio of activation of platelets exposed to crushed and uncrushed muscle supernatant in control patients and in patients on antiplatelet agents...
June 28, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28658521/the-in-vitro-mucolytic-effect-of-xylitol-and-dornase-alfa-on-chronic-rhinosinusitis-mucus
#12
Tim Hardcastle, Ravi Jain, Fiona Radcliff, Sharon Waldvogel-Thurlow, Melissa Zoing, Kristi Biswas, Richard Douglas
BACKGROUND: The overproduction and stagnation of purulent mucus impair mucociliary clearance and exacerbate the symptoms of chronic rhinosinusitis (CRS). There is a clinical need for effective topical mucolytic agents to facilitate removal of mucus and improve postoperative outcomes. METHODS: The effects of xylitol (5%) and dornase alfa (1 mg/mL) on mucus and mucus crusts were investigated. Viscoelasticity and viscosity of wet mucus derived from 30 CRS patients was measured with a plate rheometer...
June 28, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28614638/development-and-validation-of-a-3d-printed-model-of-the-ostiomeatal-complex-and-frontal-sinus-for-endoscopic-sinus-surgery-training
#13
Abdulaziz S Alrasheed, Lily H P Nguyen, Luc Mongeau, W Robert J Funnell, Marc A Tewfik
BACKGROUND: Endoscopic sinus surgery poses unique training challenges due to complex and variable anatomy, and the risk of major complications. We sought to create and provide validity evidence for a novel 3D-printed simulator of the nose and paranasal sinuses. METHODS: Sinonasal computed tomography (CT) images of a patient were imported into 3D visualization software. Segmentation of bony and soft tissue structures was then performed. The model was printed using simulated bone and soft tissue materials...
June 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28614630/prevalence-of-atopic-disease-in-patients-with-eosinophilic-esophagitis
#14
Michael S Benninger, Madeleine Strohl, Chantal E Holy, Andrea L Hanick, Paul C Bryson
BACKGROUND: The objective of this work was to evaluate prevalence of eosinophilic esophagitis (EoE) in the United States, and analyze prevalence of atopic disease in patients with EoE. The study design was a retrospective administrative database analysis in U.S.-based outpatient settings. METHODS: A retrospective claims analysis in the inpatient and outpatient setting (using MarketScan) was conducted to analyze prevalence of atopic disease diagnoses in patients with EoE in 2012, and timing of those diagnoses vs EoE...
June 14, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28597597/sinus-hypoplasia-in-the-cystic-fibrosis-rat-resolves-in-the-absence-of-chronic-infection
#15
Jessica Grayson, Kiranya E Tipirneni, Daniel F Skinner, Matthew Fort, Do-Yeon Cho, Shaoyan Zhang, Andrew C Prince, Dong-Jin Lim, Calvin Mackey, Bradford A Woodworth
BACKGROUND: Sinus hypoplasia is a hallmark characteristic in cystic fibrosis (CF). Chronic rhinosinusitis (CRS) is nearly universal from a young age, impaired sinus development could be secondary to loss of the cystic fibrosis transmembrane conductance regulator (CFTR) or consequences of chronic infection during maturation. The objective of this study was to assess sinus development relative to overall growth in a novel CF animal model. METHODS: Sinus development was evaluated in CFTR(-/-) and CFTR(+/+) rats at 3 stages of development: newborn; 3 weeks; and 16 weeks...
June 8, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28574651/impact-of-tobacco-smoke-on-upper-airway-dendritic-cell-accumulation-and-regulation-by-sinonasal-epithelial-cells
#16
Jennifer K Mulligan, Brendan P O'Connell, Whitney Pasquini, Ryan M Mulligan, Sarah Smith, Zachary M Soler, Carl Atkinson, Rodney J Schlosser
BACKGROUND: In these studies we examined the impact of environmental tobacco smoke (ETS) and active smoking on sinonasal dendritic cell (DC) subsets in controls or patients with chronic rhinosinusitis with nasal polyps (CRSwNP). In subsequent in-vitro investigations, we examined the influence of cigarette smoke extract (CSE) on human sinonasal epithelial cells' (HSNECs) ability to regulate DC functions. METHODS: Sinonasal tissue, blood, and hair were collected from patients undergoing sinus surgery...
June 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28574642/delivering-irrigation-to-the-anterior-ethmoid-region-evaluation-of-a-lacrimal-diversion-device-in-a-cadaver-model
#17
Bobby A Tajudeen, Sanjay Gupta, Brian Willoughby, David W Kennedy
BACKGROUND: Topical solutions to the sinus cavity are primarily administered via a transnasal route with inherent limitations of distribution. Here we describe an alternate method of sinus access via lacrimal sinus diversion using a novel lacrimal diversion device (LDD). METHODS: A cadaveric study was performed using 12 disarticulated fresh heads. The LDD was implanted in 23 sides meeting insertion criteria. Time to placement was recorded and patency was assessed via nasal endoscopy...
June 2, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28558148/glucosamine-has-an-antiallergic-effect-in-mice-with-allergic-asthma-and-rhinitis
#18
Ah-Yeoun Jung, Min-Jeong Heo, Young Hyo Kim
BACKGROUND: Glucosamine (GlcN) is generally used as a dietary supplement because of its antiinflammatory effects. We evaluated the antiallergic effect of GlcN in mice with allergic asthma and rhinitis. METHODS: Thirty-two mice were allocated equally into 4 groups (n = 8). In group A (control), we performed intraperitoneal/intranasal challenge using sterile saline. In group B (asthma/rhinitis), we used ovalbumin for intraperitoneal/intranasal challenge to induce allergic asthma and rhinitis...
May 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28558147/safety-and-efficacy-of-a-bioabsorbable-fluticasone-propionate-eluting-sinus-dressing-in-postoperative-management-of-endoscopic-sinus-surgery-a-randomized-clinical-trial
#19
Gwijde F J P M Adriaensen, Keng-Hua Lim, Wytske J Fokkens
BACKGROUND: Postoperative wound healing after endoscopic sinus surgery (ESS) in patients with chronic rhinosinusitis (CRS) is an important factor in procedural success. Local steroids and separation of opposing mucosa are commonly implemented to optimize healing. A bioabsorbable, fluticasone propionate (FP)-eluting implant, SinuBand FP, was assessed for its safety and efficacy when used in patients with CRS and nasal polyps, who were indicated for ESS including bilateral anterior and posterior ethmoidectomy...
May 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28558139/safety-and-tolerability-of-surfactant-nasal-irrigation
#20
Justin H Turner, Jeffanie Wu, Cindy A Dorminy, Rakesh K Chandra
BACKGROUND: Abnormal mucus composition and bacterial biofilms are thought to contribute to the pathophysiology of rhinosinusitis. Addition of a mucoactive surfactant to saline irrigation solution has been hypothesized to address these factors. We evaluated the safety and tolerability of a reformulated surfactant in a sample of normal subjects. METHODS: A total of 33 volunteers were randomly assigned to receive either surfactant solution or buffered saline at baseline in a controlled crossover study design...
May 30, 2017: International Forum of Allergy & Rhinology
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