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International Forum of Allergy & Rhinology

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https://www.readbyqxmd.com/read/27897397/development-and-validation-of-a-septoplasty-training-model-using-3-dimensional-printing-technology
#1
Mahmoud A AlReefi, Lily H P Nguyen, Luc G Mongeau, Bassam Ul Haq, Siddharth Boyanapalli, Nauman Hafeez, Francois Cegarra-Escolano, Marc A Tewfik
BACKGROUND: Providing alternative training modalities may improve trainees' ability to perform septoplasty. Three-dimensional printing has been shown to be a powerful tool in surgical training. The objectives of this study were to explain the development of our 3-dimensional (3D) printed septoplasty training model, to assess its face and content validity, and to present evidence supporting its ability to distinguish between levels of surgical proficiency. METHODS: Imaging data of a patient with a nasal septal deviation was selected for printing...
November 29, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27888649/prospective-multicenter-evaluation-of-balloon-sinus-dilation-for-treatment-of-pediatric-chronic-rhinosinusitis
#2
Zachary M Soler, Jeffrey S Rosenbloom, Douglas Skarada, Michael Gutman, Mark J Hoy, Shaun A Nguyen
BACKGROUND: Although balloon sinus dilation is a treatment option for adults with chronic rhinosinusitis (CRS), there have been few studies performed in pediatric patients. METHODS: This study was designed as a prospective, multicenter, single-arm investigation. Children (2 to 21 years old) with CRS who had failed medical management were treated with balloon sinus dilation and followed to 6 months postprocedure. RESULTS: Fifty children were treated at 4 centers; 33 participants were 2 to 12 years old (mean ± standard deviation age: 6...
November 26, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27888645/olfaction-in-patients-with-allergic-rhinitis-an-indicator-of-successful-mp-azeflu-therapy
#3
Ludger Klimek, Sophia C Poletti, Annette Sperl, Magdalena Spielhaupter, Cornel Bardenhewer, Joaquim Mullol, Karl Hörmann, Thomas Hummel
BACKGROUND: The purpose of this study was to investigate the effect of MP-AzeFlu on olfaction and the interaction between severity of allergic rhinitis and olfactory improvement after therapy. METHODS: A prospective, multicenter, observational study was performed on 47 patients with persistent allergic rhinitis. Duration and severity of allergic rhinitis was diagnosed and classified using the modified Allergic Rhinitis and its Impact on Asthma (ARIA) criteria and the proof of allergen sensitization from positive skin-prick tests, specific immonoglobulin E (IgE) in serum, and nasal provocation response...
November 26, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27888644/myrtol-standardized-affects-mucociliary-clearance
#4
Ying Ying Li, Jing Liu, Chun Wei Li, Somasundaram Subramaniam, Siew Shuen Chao, Feng Gang Yu, Noam A Cohen, Shi Li, Yun Wang
BACKGROUND: Myrtol standardized (Gelomyrtol forte) has been shown to be effective in controlling nasal symptoms of rhinosinusitis by promoting mucociliary clearance. Our aim was to evaluate the short- and long-term effects of myrtol on ciliated columnar cells and goblet cells in an in-vitro setting. METHODS: Nasal epithelial cells were harvested (42 days) from an air-liquid interface (ALI) culture of human nasal epithelial stem/progenitor cells (hNESPCs), which was derived from biopsies of nasal inferior turbinate mucosa...
November 26, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27888643/correlation-between-the-number-of-allergen-sensitizations-and-immunoglobulin-e-monosensitization-vs-polysensitization
#5
Jacob E Kuperstock, Christopher D Brook, Matthew W Ryan, Michael P Platt
BACKGROUND: The purpose of this study was to determine if total serum immunoglobulin E (IgE) could predict monosensitization compared to polysensitization in patients with allergic rhinitis (AR). METHODS: This was a retrospective study of a cohort of 1073 patients who underwent allergy testing. Differences in total IgE level between unsensitized, monosensitized, and polysensitized subjects were calculated. Pearson correlation coefficient was calculated to determine whether there was a relationship between total IgE level and the number of positive allergen sensitizations...
November 26, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27888642/histamine-h4-receptor-gene-polymorphisms-a-potential-predictor-of-oral-h1-antihistamine-efficacy-for-allergic-rhinitis
#6
Jian Gu, Xiao-Hui Mao, Xi-Zhi Yang, Hua-Fei Ao, Zhe Zhang, You Li
BACKGROUND: Our study aimed to investigate the associations between Histamine H4 receptor (HRH4) gene polymorphisms (rs77485247, rs74604924, and rs77041280) and oral H1 antihistamine efficacy for the treatment of allergic rhinitis (AR) patients. METHODS: A total of 142 AR patients were selected as a case group and 160 healthy individuals were recruited as a control group. Single nucleotide polymorphisms (SNPs) in the HRH4 gene were detected using direct sequencing...
November 26, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27879060/evidence-of-microbiota-dysbiosis-in-chronic-rhinosinusitis
#7
Michael Hoggard, Kristi Biswas, Melissa Zoing, Brett Wagner Mackenzie, Michael W Taylor, Richard G Douglas
BACKGROUND: Despite considerable research, the pathogenesis of chronic rhinosinusitis (CRS) remains poorly understood. Potential microbial roles in the etiology or progression of CRS have long been hypothesized, yet few specific associations have been identified. In this study we investigate associations between patterns in resident bacterial communities and clinical variants of CRS. METHODS: Bacterial communities were assessed in 94 patients with extensive bilateral CRS undergoing endoscopic sinus surgery (ESS) and 29 controls undergoing ESS for indications other than CRS...
November 23, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27879058/sinus-surgery-can-improve-quality-of-life-lung-infections-and-lung-function-in-patients-with-primary-ciliary-dyskinesia
#8
Mikkel Christian Alanin, Kasper Aanaes, Niels Høiby, Tania Pressler, Marianne Skov, Kim Gjerum Nielsen, Helle Krogh Johansen, Christian von Buchwald
BACKGROUND: Chronic rhinosinusitis (CRS) and bacterial sinusitis are ubiquitous in patients with primary ciliary dyskinesia (PCD). From the sinuses, Pseudomonas aeruginosa can infect the lungs. METHODS: We studied the effect of endoscopic sinus surgery (ESS) on symptoms of CRS and lower airway infections in PCD patients in a prospective single-arm intervention study of ESS with adjuvant therapy using nasal irrigation with saline, topical nasal steroids, and 2 weeks of systemic antibiotics...
November 23, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27869359/pitfalls-in-the-use-of-epinephrine-for-anaphylaxis-patient-and-provider-opportunities-for-improvement
#9
Michael B Cohen, Stefanie S Saunders, Sarah K Wise, Samih Nassif, Michael P Platt
BACKGROUND: Epinephrine remains the mainstay of treatment for life-threatening allergic reactions. A number of challenges are encountered with epinephrine, resulting in underutilization and misutilization of epinephrine. The purpose of this study was to identify the scope of epinephrine pitfalls and opportunities for improvement in the management of allergy emergencies. METHODS: A PubMed search from 1990 to 2015 was performed to identify all cases and reports pertaining to the use and misuse of epinephrine for anaphylaxis...
November 21, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27869357/the-impact-of-endoscopic-sinus-surgery-on-paranasal-physiology-in-simulated-sinus-cavities
#10
Ravi Jain, Haribalan Kumar, Merryn Tawhai, Richard Douglas
BACKGROUND: Surgery improves symptoms for the majority of chronic rhinosinusitis (CRS) patients; however, physiological changes in the sinus cavities remain poorly characterized. Direct measurement of changes in airflow, pressure, temperature, humidity, and intranasal spray distribution following surgery is technically challenging. Accordingly, we have used computational fluid dynamic modeling to quantify how these parameters change postoperatively. METHODS: Computed tomography images from a normal control, a patient with CRS preoperatively and postoperatively, and a patient following an endoscopic Lothrop procedure (ELP) were used to create 4 three-dimensional models of the sinus cavities...
November 21, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27869354/efficacy-of-olopatadine-hydrochloride-0-1-emedastine-difumarate-0-05-and-loteprednol-etabonate-0-5-for-chinese-children-with-seasonal-allergic-conjunctivitis-a-randomized-vehicle-controlled-study
#11
Rui-Fen Liu, Xiao-Xuan Wu, Xiao Wang, Jing Gao, Jun Zhou, Qi Zhao
BACKGROUND: Allergic conjunctivitis (AC) is a disease of various agents that affects the physical and mental health of children. Although the most effective therapy has not been found so far, it is essential to explore the considerable therapeutic method. We compared the clinical efficacy of olopatadine, emedastine, loteprednol etabonate (LE), and vehicle for treating seasonal allergic conjunctivitis (SAC) in Chinese children. METHODS: Eighty cases of 160 eyes aged from 5 to 10 years with SAC were available and those subjects were randomly distributed into 4 groups...
November 21, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27860385/paranasal-sinus-size-is-decreased-in-cftr-heterozygotes-with-chronic-rhinosinusitis
#12
Joshua B Calton, Pradeep C Koripella, Amanda L Willis, Christopher H Le, Alexander G Chiu, Eugene H Chang
BACKGROUND: Cystic fibrosis (CF) heterozygotes with a single mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene are at significantly higher risk to develop chronic rhinosinusitis (CRS). However the reasons why remain unknown. We tested the hypothesis that CFTR heterozygotes would have smaller sinus volumes than healthy controls. To exclude sinus disease as a confounding factor we also assessed paranasal sinus volume in those with CRS, but without known CFTR mutations...
November 17, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27865063/face-content-and-construct-validation-of-a-low-cost-non-biologic-sinus-surgery-task-trainer-and-knowledge-based-curriculum
#13
Richard A Harbison, Kaalan E Johnson, Craig Miller, Maya G Sardesai, Greg E Davis
BACKGROUND: The purpose of this study was to evaluate face and content validity of a low-cost, low-technology, non-biologic endoscopic sinus surgery (ESS) task trainer and knowledge-based curriculum followed by construct validation of the task trainer. METHODS: A sinus surgery task trainer and curriculum were developed. Attending otolaryngologists were surveyed regarding the utility of the task trainer and curriculum. A cross-sectional construct validation study was performed including medical students, residents, and attending otolaryngologists...
November 16, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27865062/endoscopic-nasopharyngectomy-in-recurrent-nasopharyngeal-carcinoma-a-case-series-literature-review-and-pooled-analysis
#14
Alexander C Vlantis, Dennis L Y Lee, Eddy W Y Wong, Samuel M W Chow, Siu K Ng, Jason Y K Chan
BACKGROUND: To critically evaluate the use of endoscopic nasopharyngectomy in the treatment of recurrent nasopharyngeal carcinoma (NPC) through a case series, systematic literature review, and pooled analysis. METHODS: A case series of 18 patients combined with systematic literature review and pooled analysis of PubMed, Web of Science, and Scopus search, identifying 576 papers. After excluding 307 papers as search engine duplicates, only 16 of the remaining papers had adequate patient data to be included...
November 16, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27863163/surgical-therapy-vs-continued-medical-therapy-for-medically-refractory-chronic-rhinosinusitis-a-systematic-review-and-meta-analysis
#15
Zara M Patel, Andrew Thamboo, Luke Rudmik, Jayakar V Nayak, Timothy L Smith, Peter H Hwang
BACKGROUND: The currently accepted treatment paradigm of treating chronic rhinosinusitis (CRS) first with appropriate medical therapy (AMT) and then with surgery if patients are refractory to AMT, has been criticized for lack of evidence. The objective of this study was to reassess the literature and establish the highest level of evidence possible regarding further management of CRS patients refractory to AMT. METHODS: This study was a systematic review (SR) with meta-analysis (MA)...
November 11, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27863156/influence-of-interpersonal-traits-on-patient-outcomes-in-the-treatment-of-chronic-rhinosinusitis
#16
Joshua M Levy, Jess C Mace, Timothy L Smith, Zachary M Soler
BACKGROUND: Patient-reported outcome measures (PROMs) measure health states in chronic rhinosinusitis (CRS) and have become the dominant metrics of treatment outcomes. Interpersonal traits (IPTs) are patient-specific factors that include personality type, perceived social support, and trust in physicians. The association of IPTs on treatment outcomes among patients with CRS has not been described previously, and IPTs may represent major clinical factors influencing treatment outcomes...
November 11, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27863150/sinonasal-adenoid-cystic-carcinoma-a-population-based-analysis-of-694-cases
#17
Aykut A Unsal, Sei Y Chung, Albert H Zhou, Soly Baredes, Jean Anderson Eloy
BACKGROUND: Currently, limited literature exists about sinonasal adenoid cystic carcinoma (SNACC). In this study, we analyze the demographics, survival, and treatment efficacy of this rare entity. METHODS: Our study was a retrospective population-based analysis of SNACC in the Surveillance, Epidemiology, and End Results (SEER) database assessing the 40-year time-frame of 1973 to 2013. RESULTS: Six hundred ninety-four SNACC patients were identified; 53...
November 11, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27863138/prevention-of-sinonasal-inflammation-by-a-synthetic-glycosaminoglycan
#18
Abigail Pulsipher, Xuan Qin, Andrew J Thomas, Glenn D Prestwich, Siam Oottamasathien, Jeremiah A Alt
BACKGROUND: Glycosaminoglycans (GAGs) are polysaccharides that are distributed on respiratory epithelial cells, endothelial cells, and submucosal glands. Uniquely positioned, certain GAGs exhibit anti-inflammatory properties in respiratory diseases and serve important roles in repairing mucosal surfaces and modulating mucociliary clearance. We hypothesized that topical administration of a synthetic GAG (GM-0111) would prevent sinonasal inflammation in a mouse model of rhinosinusitis (RS)...
November 11, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27860447/fluorescein-guided-intraoperative-endoscopy-in-patients-with-hereditary-hemorrhagic-telangiectasia-first-impressions
#19
Fabio Pagella, Alessandro Pusateri, Dario Zaccari, Daniele Bongetta, Cesare Zoia, Giuseppe Spinozzi, Carla Olivieri, Elina Matti
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is a rare genetic disease that results in mucocutaneous telangiectasias and arteriovenous visceral malformations. Nasal telangiectasias lead to recurrent epistaxis, which affects up to 96% of patients. Different morphologic classifications and methods of visualization of nasal lesions have been described in the literature. We developed a new method of intraoperative endoscopy based on the intravenous administration of fluorescein...
November 11, 2016: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/27754596/educational-utility-of-advanced-three-dimensional-virtual-imaging-in-evaluating-the-anatomical-configuration-of-the-frontal-recess
#20
Abib Agbetoba, Amber Luong, Jin Keat Siow, Brent Senior, Claudio Callejas, Kornel Szczygielski, Martin J Citardi
BACKGROUND: Endoscopic sinus surgery represents a cornerstone in the professional development of otorhinolaryngology trainees. Mastery of these surgical skills requires an understanding of paranasal sinus and skull-base anatomy. The frontal sinus is associated with a wide range of variation and complex anatomical configuration, and thus represents an important challenge for all trainees performing endoscopic sinus surgery. METHODS: Forty-five otorhinolaryngology trainees and 20 medical school students from 5 academic institutions were enrolled and randomized into 1 of 2 groups...
October 18, 2016: International Forum of Allergy & Rhinology
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