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International Journal of Nephrology and Renovascular Disease

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https://www.readbyqxmd.com/read/29588610/unmet-service-needs-evaluated-by-case-managers-among-disabled-patients-on-hemodialysis-in-japan
#1
Hidehiro Sugisawa, Toshio Shinoda, Yumiko Shimizu, Tamaki Kumagai, Hiroaki Sugisaki, Seiji Ohira
Background: This study aimed to investigate the levels of unmet needs for home and community-based services (HCBS) evaluated by case managers (CMs) among disabled patients on hemodialysis (DPHD) and to examine factors related to unmet needs. Unmet needs for HCBS were defined as situations in which patients do not use or underuse HCBS despite needing them. Candidates for the factors relating to unmet needs for HCBS included three dimensions: predisposing, enabling, and need factors. Methods: Self-administrated questionnaires were collected from 391 CMs of DPHD certified with long-term care insurance...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29559807/bold-magnetic-resonance-imaging-in-nephrology
#2
REVIEW
Michael E Hall, Jennifer H Jordan, Luis A Juncos, W Gregory Hundley, John E Hall
Magnetic resonance (MR) imaging, a non-invasive modality that provides anatomic and physiologic information, is increasingly used for diagnosis of pathophysiologic conditions and for understanding renal physiology in humans. Although functional MR imaging methods were pioneered to investigate the brain, they also offer powerful techniques for investigation of other organ systems such as the kidneys. However, imaging the kidneys provides unique challenges due to potential complications from contrast agents. Therefore, development of non-contrast techniques to study kidney anatomy and physiology is important...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29559806/anxiety-and-depression-in-patients-with-end-stage-renal-disease-impact-and-management-challenges-a-narrative-review
#3
REVIEW
Zhong Sheng Goh, Konstadina Griva
Psychiatric disorders commonly co-exist with the diagnosis of chronic kidney disease (CKD). Research on depression and CKD has increased to a great extent. Multiple studies have demonstrated that depression is more prevalent in CKD and that end-stage renal disease is a robust risk factor for adverse outcomes such as hospitalization and mortality, yet these are often underdiagnosed or untreated. This review provides a selective overview on the prevalence rates of depression and anxiety in patients with CKD and across renal replacement therapies, the factors most consistently associated with symptoms of distress and their clinical implications...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29497325/the-importance-of-the-thick-ascending-limb-of-henle-s-loop-in-renal-physiology-and-pathophysiology
#4
REVIEW
Miriam Zacchia, Giovanna Capolongo, Luca Rinaldi, Giovambattista Capasso
The thick ascending limb (TAL) of Henle's loop is a crucial segment for many tasks of the nephron. Indeed, the TAL is not only a mainstay for reabsorption of sodium (Na+ ), potassium (K+ ), and divalent cations such as calcium (Ca2+ ) and magnesium (Mg2+ ) from the luminal fluid, but also has an important role in urine concentration, overall acid-base homeostasis, and ammonia cycle. Transcellular Na+ transport along the TAL is a prerequisite for Na+ , K+ , Ca2+ , Mg2+ homeostasis, and water reabsorption, the latter through its contribution in the generation of the cortico-medullar osmotic gradient...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29440923/managing-hyperparathyroidism-in-hemodialysis-role-of-etelcalcetide
#5
REVIEW
Keith E Eidman, James B Wetmore
Secondary hyperparathyroidism (SHPT) is common in patients receiving maintenance hemodialysis and is associated with adverse outcomes. Currently, SHPT is managed by reducing circulating levels of phosphate with oral binders and parathyroid hormone (PTH) with vitamin D analogs and/or the calcimimetic cinacalcet. Etelcalcetide, a novel calcimimetic administered intravenously (IV) at the end of a hemodialysis treatment session, effectively reduces PTH in clinical trials when given thrice weekly. Additional clinical effects include reductions in circulating levels of phosphate and FGF-23 and an improved profile of markers of bone turnover...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29440922/is-the-light-at-the-end-of-the-tunnel-nigh-a-review-of-adpkd-focusing-on-the-burden-of-disease-and-tolvaptan-as-a-new-treatment
#6
REVIEW
Rashid A Barnawi, Rahaf Z Attar, Sultan S Alfaer, Osama Y Safdar
Autosomal dominant polycystic kidney disease (ADPKD) causes pathological cystic changes to the kidney and is characterized by numerous renal and systemic manifestations. ADPKD is the fourth most common renal disease requiring renal replacement therapy. In this report, we present a detailed review of ADPKD, with a particular focus on its major economic, psychological, and social burden in affected patients. Treatment of this disease has been based on prophylactic and supportive measures. However, in recent years, new drugs have emerged as promising agents that may retard the progression of ADPKD, such as tolvaptan...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29430193/tolvaptan-in-the-treatment-of-autosomal-dominant-polycystic-kidney-disease-patient-selection-and-special-considerations
#7
REVIEW
Laia Sans-Atxer, Dominique Joly
Standard of care therapies for autosomal dominant polycystic kidney disease (ADPKD) may limit morbidity and mortality due to disease-related complications, but they do not delay disease progression. Tolvaptan, a selective vasopressin V2 receptor antagonist, delays the increase in kidney volume (a surrogate marker for disease progression), slows the decline in renal function, and reduces pain in ADPKD patients with relatively preserved renal function. The most common adverse events of tolvaptan are linked to its aquaretic effect, and rare cases of idiosyncratic hepatitis were observed...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29403303/the-clinicopathological-features-of-patients-with-membranous-nephropathy
#8
Hanyu Zhu, Qiuxia Han, Dong Zhang, Yong Wang, Jing Gao, Xiaoli Yang, Wenjia Geng, Xiangmei Chen
Background: Membranous nephropathy (MN) represents a distinct glomerular disease which has been considered as a major cause of nephrotic syndrome (NS) in adults. Evidences show that the clinicopathological features of MN are various among MN cases. This study aimed to summarize and analyze the clinicopathological features of patients with MN. Methods: A total of 231 MN patients were recruited in this study. Their clinical and pathological features were collected and analyzed according to their age, gender, pathological stages, and anti-phospholipase A2 receptor (anti-PLA2R) antibodies tests...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29391823/pulse-versus-daily-oral-alfacalcidol-treatment-of-secondary-hyperparathyroidism-in-hemodialysis-patients-a-randomized-controlled-trial
#9
Osama Sawalmeh, Shaheed Moala, Zakaria Hamdan, Huda Masri, Khubaib Ayoub, Emad Khazneh, Mujahed Shraim
Background: Secondary hyperparathyroidism is a common complication of chronic kidney disease and is managed using vitamin D replacement therapy. Very few studies have examined the effectiveness of pulse alfacalcidol therapy in comparison to daily oral alfacalcidol therapy in suppressing serum parathyroid hormone (PTH) levels in hemodialysis patients. The aim of this randomized controlled trial was to replicate the findings of prior studies comparing effectiveness of pulse oral alfacalcidol therapy versus daily oral alfacalcidol therapy in suppressing PTH after 13 weeks of therapy using a Palestinian sample of hemodialysis patients, and to identify demographic and biomedical characteristics of patients that are independently associated with PTH levels...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29391822/post-marketing-surveillance-study-of-the-safety-and-efficacy-of-nalfurafine-hydrochloride-remitch%C3%A2-capsules-2-5-%C3%AE-g-in-3-762-hemodialysis-patients-with-intractable-pruritus
#10
Hideki Kozono, Hiroshi Yoshitani, Ryoko Nakano
Background: Intractable pruritus in hemodialysis patients can significantly decrease their quality of life and is also associated with poor vital prognosis. Although combined multiple causes of intractable pruritus in these patients have been identified, no existing treatments are proven to be sufficiently effective. We conducted a post-marketing surveillance to follow-up and assess the safety and efficacy of nalfurafine, a selective κ-opioid receptor agonist, for the treatment of intractable pruritus in patients undergoing hemodialysis...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29317843/calcium-channel-blockade-and-survival-in-recipients-of-successful-renal-transplant-an-analysis-of-the-favorit-trial-results
#11
Larry A Weinrauch, Jiankang Liu, Brian Claggett, Peter V Finn, Matthew R Weir, John A D'Elia
Introduction: Single-center and observational studies have suggested that calcium channel blocking agents may decrease the expression of sepsis in individual populations. In the renal transplant population, a role for calcium channel blockers in allograft protection and in prevention of sepsis has been postulated. We hypothesized that any important survival benefit or risk related to chronic use of calcium channel blocking agents should be discernable through an analysis of a large database of stable recipients of renal allografts who had enrolled in a large international trial...
2018: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29263687/nutcracker-syndrome-associated-with-celiacomesentric-trunk-anomaly-case-report
#12
Nabil A Al-Zoubi, Ibrahim F Al-Ghalayini, Radwan Al-Okour
Introduction: Nutcracker syndrome is a rare disease entity that is caused by entrapment of the left renal vein between the aorta and superior mesenteric artery, usually due to abnormal branching of the superior mesenteric artery from the aorta causing renal venous hypertension. The symptoms vary from asymptomatic hematuria to severe pelvic congestion. Celiacomes-enteric trunk anomaly is a rare variation of splanchnic artery anomaly that occurs when the celiac trunk and superior mesenteric arteries have a common origin from the aorta...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29075132/urinary-protein-profiles-in-ketorolac-associated-acute-kidney-injury-in-patients-undergoing-orthopedic-day-surgery
#13
Filippo Mariano, Chiara Cogno, Fulvia Giaretta, Ilaria Deambrosis, Simona Pozza, Maurizio Berardino, Giuseppe Massazza, Luigi Biancone
BACKGROUND: Parenteral administration of ketorolac is very effective in controlling postoperative pain for orthopedic surgery. Ketorolac can induce clinically relevant renal alterations in elderly patients, whereas its short course is considered safe for young adults with normal preoperative renal function. In this study, of a cohort of young adults undergoing elective orthopedic day surgery, we sought cases complicated by readmission due to acute kidney injury (AKI). PATIENTS AND METHODS: Among 1397 young adults, aged 18-32 years who were admitted to undergo orthopedic day surgery from 2013 to 2015, four patients (0...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/29033600/efficacy-and-safety-of-subcutaneous-administration-of-lyophilized-powder-of-alfa-erythropoietin-to-maintain-hemoglobin-concentrations-among-hemodialysis-patients
#14
Bancha Satirapoj, Rattanawan Dispan, Ouppatham Supasyndh
BACKGROUND: Anemia associated with chronic kidney disease (CKD) often requires treatment with recombinant human erythropoietin (EPO). This study investigated the therapeutic equivalence between lyophilized powder and standard liquid EPO alfa by subcutaneous (SC) administration in hemoglobin maintenance among patients on hemodialysis. METHODS: This was a single-blinded, randomized, controlled, single-center, parallel-group study regarding the treatment of anemia among CKD patients on hemodialysis and being treated with stable doses of EPO alfa at least for 12 weeks...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28979155/role-of-serum-cystatin-c-and-beta-2-microglobulin-as-early-markers-of-renal-dysfunction-in-children-with-beta-thalassemia-major
#15
Ola Galal Behairy, Eman Rateb Abd Almonaem, Neveen Tawfik Abed, Omima M Abdel Haiea, Rasha M Zakaria, Rania I AbdEllaty, Effat H Asr, Amira Ibrahim Mansour, Amira Mn Abdelrahman, Hoda A Elhady
BACKGROUND: Although advancements have been made in the management of thalassemic patients, many unrecognized complications have emerged, such as renal abnormalities. AIM: To measure serum levels of cystatin-C and β-2 microglobulin in children with beta-thalassemia major (β-TM) and investigate their significance as early markers of glomerular and tubular dysfunctions. SUBJECTS AND METHODS: The study was performed on 70 children with (β-TM) and 20 apparently healthy children matched for age and sex as a control group...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28919801/transforming-growth-factor-%C3%AE-1-smad3-independent-epithelial-mesenchymal-transition-in-type-i-collagen-glomerulopathy
#16
Amanda C Brodeur, Anna M Roberts-Pilgrim, Kimberlee L Thompson, Craig L Franklin, Charlotte L Phillips
The glomerulofibrotic Col1a2-deficient mouse model demonstrates glomerular homotrimeric type I collagen deposition in mesangial and subendothelial spaces. In this report, we investigate the role of transforming growth factor β1 (TGF-β1) in myofibroblast activation and epithelial-mesenchymal transition (EMT) in this glomerulopathy. Immunohistochemical analyses of glomerular α-sma, desmin, vimentin, and proliferating cell nuclear antigen demonstrated parietal epithelial cell proliferation and EMT in late stages of the glomerulopathy in the Col1a2-deficient mice...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28919800/renal-sympathetic-denervation-increases-renal-blood-volume-per-cardiac-cycle-a-serial-magnetic-resonance-imaging-study-in-resistant-hypertension
#17
Sinny Delacroix, Ramesh G Chokka, Adam J Nelson, Dennis T Wong, Samuel Sidharta, Stephen M Pederson, Adil Rajwani, Joanne Nimmo, Karen S Teo, Stephen G Worthley
AIM: Preclinical studies have demonstrated improvements in renal blood flow after renal sympathetic denervation (RSDN); however, such effects are yet to be confirmed in patients with resistant hypertension. Herein, we assessed the effects of RSDN on renal artery blood flow and diameter at multiple time points post-RSDN. METHODS AND RESULTS: Patients (n=11) with systolic blood pressures ≥160 mmHg despite taking three or more antihypertensive medications at maximum tolerated dose were recruited into this single-center, prospective, non-blinded study...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28860838/does-diabetes-impact-therapeutic-immunomodulation-therapy-decisions-for-kidney-transplant-recipients-data-from-the-folic-acid-for-vascular-outcome-reduction-in-transplant-favorit-trial
#18
Larry A Weinrauch, John A D'Elia, Matthew R Weir, Suphamai Bunnapradist, Peter Finn, Jiankang Liu, Brian Claggett, Anthony P Monaco
Although survival has improved for kidney transplant recipients over the past several decades, long-term survival in diabetic cohorts still is significantly less than that of non-diabetic cohorts. We hypothesized that among stable kidney transplant recipients, there might be differences between subgroups with and without diabetes with respect to prevalence of prior cardiovascular events and post-transplant antihypertensive and immunosuppressive therapy. We performed a post hoc analysis of participants in the Folic Acid for Vascular Outcome Reduction in Transplant (FAVORIT) trial, a multicenter international trial of 4110 prevalent kidney transplant recipients enrolled from 2002 to 2007 evaluating the effect of homocysteine-lowering vitamin therapy on cardiovascular outcomes...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28860837/the-role-of-novel-biomarkers-in-predicting-diabetic-nephropathy-a-review
#19
REVIEW
Samuel N Uwaezuoke
Diabetic nephropathy (DN) is one of the microvascular complications of the kidney arising commonly from type 1 diabetes mellitus (T1DM), and occasionally from type 2 diabetes mellitus (T2DM). Microalbuminuria serves as an early indicator of DN risk and a predictor of its progression as well as cardiovascular disease risk in both T1DM and T2DM. Although microalbuminuria remains the gold standard for early detection of DN, it is not a sufficiently accurate predictor of DN risk due to some limitations. Thus, there is a paradigm shift to novel biomarkers which would help to predict DN risk early enough and possibly prevent the occurrence of end-stage kidney disease...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28794652/stent-tunnel-technique-to-save-thrombosed-native-hemodialysis-fistula-with-extensive-venous-aneurysm
#20
Martin Rabellino, Guillermo J Rosa-Diez, Sergio A Shinzato, Pablo Rodriguez, Oscar A Peralta, Maria S Crucelegui, Rosario Luxardo, Agustina Heredia-Martinez, Mariela I Bedini-Rocca, Ricardo D García-Mónaco
INTRODUCTION AND PURPOSE: The increasing number of patients undergoing hemodialysis and the limited number of access sites have resulted in an increasing number of techniques to maintain vascular access for hemodialysis. Thrombosed arteriovenous (AV) fistulas with large venous aneurysms have poor treatment results, with both endovascular and surgical techniques, leading to a high rate of definitive AV access loss. The purpose of this study was to review the feasibility and initial results of this novel endovascular treatment of thrombosed AV fistulas with large venous aneurysms...
2017: International Journal of Nephrology and Renovascular Disease
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