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Journal of Tissue Engineering

James R Henstock, Michael Rotherham, Alicia J El Haj
Magnetic ion channel activation technology uses superparamagnetic nanoparticles conjugated with targeting antibodies to apply mechanical force directly to stretch-activated ion channels on the cell surface, stimulating mechanotransduction and downstream processes. This technique has been reported to promote differentiation towards musculoskeletal cell types and enhance mineralisation. Previous studies have shown how mesenchymal stem cells injected into a pre-mineralised environment such as a foetal chick epiphysis, results in large-scale osteogenesis at the target site...
January 2018: Journal of Tissue Engineering
Jung-Hwan Lee, Min Young Lee, Yohan Lim, Jonathan Knowles, Hae-Won Kim
Auditory function takes a major part in human life. While sensorineural hearing loss is related with many factors including genetic disorders, age and noise, the clear causes are not well understood. Even more, the currently available treatments with drugs cause side effects, which thus are considered suboptimal. Here, we communicate the delivery systems with biomaterials that can be possible therapeutic options to restore hearing and vestibular functions. We introduce briefly the various pathological factors related with hearing loss and the limitation of current therapies, detail the recent studies on delivery systems including nanoparticles and hydrogels and discuss future clinical availability...
January 2018: Journal of Tissue Engineering
Ho-Jin Moon, Jung-Hwan Lee, Joong-Hyun Kim, Jonathan C Knowles, Yong-Bum Cho, Dong-Hoon Shin, Hae-Hyoung Lee, Hae-Won Kim
Mineral trioxide aggregate, which comprises three major inorganic components, namely, tricalcium silicate (C3S), dicalcium silicate (C2S), and tricalcium aluminate (C3A), is promising regenerative cement for dentistry. While mineral trioxide aggregate has been successfully applied in retrograde filling, the exact role of each component in the mineral trioxide aggregate system is largely unexplored. In this study, we individually synthesized the three components, namely, C3S, C2A, and C3A, and then mixed them to achieve various compositions (a total of 14 compositions including those similar to mineral trioxide aggregate)...
January 2018: Journal of Tissue Engineering
Guang-Zhen Jin, Hae-Won Kim
Dedifferentiation of chondrocytes remains a major problem in cartilage tissue engineering. The development of hydrogels that can preserve chondrogenic phenotype and prevent chondrocyte dedifferentiation is a meaningful strategy to solve dedifferentiation problem of chondrocytes. In the present study, three gels were prepared (alginate gel (Alg gel), type I collagen gel (Col gel), and their combination gel (Alg/Col gel)), and the in vitro efficacy of chondrocytes culture while preserving their phenotypes was investigated...
January 2018: Journal of Tissue Engineering
Patrick Rider, Željka Perić Kačarević, Said Alkildani, Sujith Retnasingh, Mike Barbeck
Bioprinting is the process of creating three-dimensional structures consisting of biomaterials, cells, and biomolecules. The current additive manufacturing techniques, inkjet-, extrusion-, and laser-based, create hydrogel structures for cellular encapsulation and support. The requirements for each technique, as well as the technical challenges of printing living cells, are discussed and compared. This review encompasses the current research of bioprinting for tissue engineering and its potential for creating tissue-mimicking structures...
January 2018: Journal of Tissue Engineering
Jianying Zhang, Daibang Nie, Jorge L Rocha, MaCalus V Hogan, James H-C Wang
In this study, we report that human plantar fascia consists of two distinct tissues with differential structural properties. These tissues also contain stem/progenitor cells with differential biological properties. The mechanobiological responses of these two plantar fascia stem cells also differ in terms of expression of collagen I and IV, non-ligament-related genes, and proinflammatory genes. The production of inflammatory agents (prostaglandin E2 , interleukin-6) and matrix degradative enzymes (matrix metalloproteinase-1, matrix metalloproteinase-2) are also different between the two types of plantar fascia stem cells...
January 2018: Journal of Tissue Engineering
Ilida Ortega Asencio, Shweta Mittar, Colin Sherborne, Ahtasham Raza, Frederik Claeyssens, Sheila MacNeil
The continual renewal of the epidermis is thought to be related to the presence of populations of epidermal stem cells residing in physically protected microenvironments (rete ridges) directly influenced by the presence of mesenchymal fibroblasts. Current skin in vitro models do acknowledge the influence of stromal fibroblasts in skin reorganisation but the study of the effect of the rete ridge-microenvironment on epidermal renewal still remains a rich topic for exploration. We suggest there is a need for the development of new in vitro models in which to study epithelial stem cell behaviour prior to translating these models into the design of new cell-free biomaterial devices for skin reconstruction...
January 2018: Journal of Tissue Engineering
Sneha Mehta, Brooke McClarren, Ayesha Aijaz, Rabab Chalaby, Kimberly Cook-Chennault, Ronke M Olabisi
Low-magnitude, high-frequency vibration has stimulated osteogenesis in mesenchymal stem cells when these cells were cultured in certain types of three-dimensional environments. However, results of osteogenesis are conflicting with some reports showing no effect of vibration at all. A large number of vibration studies using three-dimensional scaffolds employ scaffolds derived from natural sources. Since these natural sources potentially have inherent biochemical and microarchitectural cues, we explored the effect of low-magnitude, high-frequency vibration at low, medium, and high accelerations when mesenchymal stem cells were encapsulated in poly(ethylene glycol) diacrylate microspheres...
January 2018: Journal of Tissue Engineering
Shona J Waddell, María C de Andrés, Penelope M Tsimbouri, Enateri V Alakpa, Maggie Cusack, Matthew J Dalby, Richard Oc Oreffo
The regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central issue remains efficacious, controlled cell differentiation strategies to aid progression of cell therapies to the clinic. The nacre surface from Pinctada maxima shells is known to enhance bone formation. However, to date, there is a paucity of information on the role of the topography of P. maxima surfaces, nacre and prism. To investigate this, nacre and prism topographical features were replicated onto polycaprolactone and skeletal stem cell behaviour on the surfaces studied...
January 2018: Journal of Tissue Engineering
Jonathan Knowles, Hae-Won Kim
No abstract text is available yet for this article.
January 2018: Journal of Tissue Engineering
Ryo Torii, Rallia-Iliana Velliou, David Hodgson, Vivek Mudera
Expectation on engineered tissue substitute continues to grow, and for an effective development of a functional tissue and to control its quality, cellular mechanoresponse plays a key role. Although the mechanoresponse - in terms of cell-tissue interaction across scales - has been understood better in recent years, there are still technical limitations to quantitatively monitor the processes involved in the development of both native and engineered tissues. Computational (in silico) studies have been utilised to complement the experimental limitations and successfully applied to the prediction of tissue growth...
January 2018: Journal of Tissue Engineering
Laila Damiati, Marcus G Eales, Angela H Nobbs, Bo Su, Penelope M Tsimbouri, Manuel Salmeron-Sanchez, Matthew J Dalby
Titanium (Ti) plays a predominant role as the material of choice in orthopaedic and dental implants. Despite the majority of Ti implants having long-term success, premature failure due to unsuccessful osseointegration leading to aseptic loosening is still too common. Recently, surface topography modification and biological/non-biological coatings have been integrated into orthopaedic/dental implants in order to mimic the surrounding biological environment as well as reduce the inflammation/infection that may occur...
January 2018: Journal of Tissue Engineering
Elisa Costa, Cristina González-García, José Luis Gómez Ribelles, Manuel Salmerón-Sánchez
Articular chondrocytes are difficult to grow, as they lose their characteristic phenotype following expansion on standard tissue culture plates. Here, we show that culturing them on surfaces of poly(L-lactic acid) of well-defined microtopography allows expansion and maintenance of characteristic chondrogenic markers. We investigated the dynamics of human chondrocyte dedifferentiation on the different poly(L-lactic acid) microtopographies by the expression of collagen type I, collagen type II and aggrecan at different culture times...
January 2018: Journal of Tissue Engineering
Kyoung-Suk Moon, Young-Bum Park, Ji-Myung Bae, Seunghan Oh
The infection control of implants is one of the hot issues in the field of medicine and dentistry. In this study, we prepared gold nanorod-sputtered titania nanotubes on titanium surface, which is the main component of implant material, and aimed to estimate the remote-controlled tetracycline release and resulting antibacterial effects of gold nanorod-sputtered titania nanotubes using near-infrared laser irradiation. Gold nanorods prepared by ion plasma sputtering (aspect ratio = 1:3) showed optical properties like those of chemically synthesized gold nanorods, exhibiting photothermal effects in the near-infrared region, as demonstrated using field-emission scanning electron microscopy, transmission electron microscopy, and diffuse ultraviolet-visible-near-infrared spectrophotometry...
January 2018: Journal of Tissue Engineering
Wich Orapiriyakul, Peter S Young, Laila Damiati, Penelope M Tsimbouri
The use of biomaterials in orthopaedics for joint replacement, fracture healing and bone regeneration is a rapidly expanding field. Infection of these biomaterials is a major healthcare burden, leading to significant morbidity and mortality. Furthermore, the cost to healthcare systems is increasing dramatically. With advances in implant design and production, research has predominately focussed on osseointegration; however, modification of implant material, surface topography and chemistry can also provide antibacterial activity...
January 2018: Journal of Tissue Engineering
Michaela Rödel, Katrin Baumann, Jürgen Groll, Uwe Gbureck
Silk fibroin is commonly used as scaffold material for tissue engineering applications. In combination with a mineralization with different calcium phosphate phases, it can also be applied as material for bone regeneration. Here, we present a study which was performed to produce mineralized silk fibroin scaffolds with controlled macroporosity. In contrast to former studies, our approach focused on a simultaneous gelation and mineralization of silk fibroin by immersion of frozen silk fibroin monoliths in acidic calcium phosphate solutions...
January 2018: Journal of Tissue Engineering
Christopher Allan, Andrew Ker, Carol-Anne Smith, Penelope M Tsimbouri, Juliana Borsoi, Stewart O'Neill, Nikolaj Gadegaard, Matthew J Dalby, R M Dominic Meek
The ability to influence stem cell differentiation is highly desirable as it would help us improve clinical outcomes for patients in various aspects. Many different techniques to achieve this have previously been investigated. This concise study, however, has focused on the topography on which cells grow. Current uncemented orthopaedic implants can fail if the implant fails to bind to the surrounding bone and, typically, forms a soft tissue interface which reduces direct bone contact. Here, we look at the effect of a previously reported nanotopography that utilises nanodisorder to influence mesenchymal stromal cell (as may be found in the bone marrow) differentiation towards bone and to also exert this effect on mature osteoblasts (as may be found in the bone)...
January 2018: Journal of Tissue Engineering
Alexandra Levin, Vaibhav Sharma, Lilian Hook, Elena García-Gareta
This article presents a case study to show the usefulness and importance of using factorial design in tissue engineering and biomaterials science. We used a full factorial experimental design (2 × 2 × 2 × 3) to solve a routine query in every biomaterial research project: the optimisation of cell seeding efficiency for pre-clinical in vitro cell studies, the importance of which is often overlooked. In addition, tissue-engineered scaffolds can be cellularised with relevant cell type(s) to form implantable tissue constructs, where the cell seeding method must be reliable and robust...
January 2018: Journal of Tissue Engineering
Gabriel Fernandez de Grado, Laetitia Keller, Ysia Idoux-Gillet, Quentin Wagner, Anne-Marie Musset, Nadia Benkirane-Jessel, Fabien Bornert, Damien Offner
Bone replacement might have been practiced for centuries with various materials of natural origin, but had rarely met success until the late 19th century. Nowadays, many different bone substitutes can be used. They can be either derived from biological products such as demineralized bone matrix, platelet-rich plasma, hydroxyapatite, adjunction of growth factors (like bone morphogenetic protein) or synthetic such as calcium sulfate, tri-calcium phosphate ceramics, bioactive glasses, or polymer-based substitutes...
January 2018: Journal of Tissue Engineering
Shiva Kamini Divakarla, Seiji Yamaguchi, Tadashi Kokubo, Dong-Wook Han, Jae Ho Lee, Wojciech Chrzanowski
The leading reason for implant revision surgery globally is lack of implant integration with surrounding bone. A new titanium alloy GUMMETAL® (Ti59 Nb36 Ta2 Zr3 O0.3 ) is currently used in biomedical devices and has a Young's modulus that is better matched to bone. The surface was subject to NaOH, CaCl2 , heat and water treatment (BioGum) after which the surfaces were evaluated using atomic force microscope, scanning electron microscope, X-ray diffractometer and elemental analysis using energy dispersive X-ray...
January 2018: Journal of Tissue Engineering
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