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Journal of Tissue Engineering

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https://www.readbyqxmd.com/read/28717506/injectable-scaffold-materials-differ-in-their-cell-instructive-effects-on-primary-human-myoblasts
#1
Eva Kildall Hejbøl, Jeeva Sellathurai, Prabha Damodaran Nair, Henrik Daa Schrøder
Scaffolds are materials used for delivery of cells for regeneration of tissues. They support three-dimensional organization and improve cell survival. For the repair of small skeletal muscles, injections of small volumes of cells are attractive, and injectable scaffolds for delivery of cells offer a minimally invasive technique. In this study, we examined in vitro the cell instructive effects of three types of injectable scaffolds, fibrin, alginate, and poly(lactic-co-glycolic acid)-based microparticles on primary human myoblasts...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28634532/cellularizing-hydrogel-based-scaffolds-to-repair-bone-tissue-how-to-create-a-physiologically-relevant-micro-environment
#2
Mathieu Maisani, Daniele Pezzoli, Olivier Chassande, Diego Mantovani
Tissue engineering is a promising alternative to autografts or allografts for the regeneration of large bone defects. Cell-free biomaterials with different degrees of sophistication can be used for several therapeutic indications, to stimulate bone repair by the host tissue. However, when osteoprogenitors are not available in the damaged tissue, exogenous cells with an osteoblast differentiation potential must be provided. These cells should have the capacity to colonize the defect and to participate in the building of new bone tissue...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28616152/magnetically-levitated-mesenchymal-stem-cell-spheroids-cultured-with-a-collagen-gel-maintain-phenotype-and-quiescence
#3
Natasha S Lewis, Emily El Lewis, Margaret Mullin, Helen Wheadon, Matthew J Dalby, Catherine C Berry
Multicellular spheroids are an established system for three-dimensional cell culture. Spheroids are typically generated using hanging drop or non-adherent culture; however, an emerging technique is to use magnetic levitation. Herein, mesenchymal stem cell spheroids were generated using magnetic nanoparticles and subsequently cultured within a type I collagen gel, with a view towards developing a bone marrow niche environment. Cells were loaded with magnetic nanoparticles, and suspended beneath an external magnet, inducing self-assembly of multicellular spheroids...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28616151/therapeutic-potential-of-dental-stem-cells
#4
REVIEW
Elna Paul Chalisserry, Seung Yun Nam, Sang Hyug Park, Sukumaran Anil
Stem cell biology has become an important field in regenerative medicine and tissue engineering therapy since the discovery and characterization of mesenchymal stem cells. Stem cell populations have also been isolated from human dental tissues, including dental pulp stem cells, stem cells from human exfoliated deciduous teeth, stem cells from apical papilla, dental follicle progenitor cells, and periodontal ligament stem cells. Dental stem cells are relatively easily obtainable and exhibit high plasticity and multipotential capabilities...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28567273/bone-and-cartilage-differentiation-of-a-single-stem-cell-population-driven-by-material-interface
#5
Hannah Donnelly, Carol-Anne Smith, Paula E Sweeten, Nikolaj Gadegaard, Rm Dominic Meek, Matteo D'Este, Alvaro Mata, David Eglin, Matthew J Dalby
Adult stem cells, such as mesenchymal stem cells, are a multipotent cell source able to differentiate towards multiple cell types. While used widely in tissue engineering and biomaterials research, they present inherent donor variability and functionalities. In addition, their potential to form multiple tissues is rarely exploited. Here, we combine an osteogenic nanotopography and a chondrogenic hyaluronan hydrogel with the hypothesis that we can make a complex tissue from a single multipotent cell source with the exemplar of creating a three-dimensional bone-cartilage boundary environment...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28560015/a-mini-review-focused-on-the-proangiogenic-role-of-silicate-ions-released-from-silicon-containing-biomaterials
#6
REVIEW
Khandmaa Dashnyam, Ahmed El-Fiqi, Jennifer O Buitrago, Roman A Perez, Jonathan C Knowles, Hae-Won Kim
Angiogenesis is considered an important issue in the development of biomaterials for the successful regeneration of tissues including bone. While growth factors are commonly used with biomaterials to promote angiogenesis, some ions released from biomaterials can also contribute to angiogenic events. Many silica-based biomaterials have been widely used for the repair and regeneration of tissues, mainly hard tissues such as bone and tooth structure. They have shown excellent performance in bone formation by stimulating angiogenesis...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28540031/outgrowing-endothelial-and-smooth-muscle-cells-for-tissue-engineering-approaches
#7
Moritz Kolster, Mathias Wilhelmi, Claudia Schrimpf, Andres Hilfiker, Axel Haverich, Thomas Aper
In recent years, circulating progenitors of endothelial cells and smooth muscle cells were identified in the peripheral blood. In our study, we evaluated the utilization of both cell types isolated and differentiated from peripheral porcine blood in terms for their use for tissue engineering purposes. By means of density gradient centrifugation, the monocyte fraction from porcine blood was separated, split, and cultivated with specific culture media with either endothelial cell growth medium-2 or smooth muscle cell growth medium-2 for the differentiation of endothelial cells or smooth muscle cells...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28540030/human-platelet-rich-plasma-improves-the-nesting-and-differentiation-of-human-chondrocytes-cultured-in-stabilized-porous-chitosan-scaffolds
#8
Maria Sancho-Tello, Sara Martorell, Manuel Mata Roig, Lara Milián, M A Gámiz-González, Jose Luis Gómez Ribelles, Carmen Carda
The clinical management of large-size cartilage lesions is difficult due to the limited regenerative ability of the cartilage. Different biomaterials have been used to develop tissue engineering substitutes for cartilage repair, including chitosan alone or in combination with growth factors to improve its chondrogenic properties. The main objective of this investigation was to evaluate the benefits of combining activated platelet-rich plasma with a stabilized porous chitosan scaffold for cartilage regeneration...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28507726/adapting-tissue-engineered-in-vitro-cns-models-for-high-throughput-study-of-neurodegeneration
#9
Caitriona O'Rourke, Charlotte Lee-Reeves, Rosemary Al Drake, Grant Ww Cameron, A Jane Loughlin, James B Phillips
Neurodegenerative conditions remain difficult to treat, with the continuing failure to see therapeutic research successfully advance to clinical trials. One of the obstacles that must be overcome is to develop enhanced models of disease. Tissue engineering techniques enable us to create organised artificial central nervous system tissue that has the potential to improve the drug development process. This study presents a replicable model of neurodegenerative pathology through the use of engineered neural tissue co-cultures that can incorporate cells from various sources and allow degeneration and protection of neurons to be observed easily and measured, following exposure to neurotoxic compounds - okadaic acid and 1-methyl-4-phenylpyridinium...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28491274/biomimetic-strategies-for-fracture-repair-engineering-the-cell-microenvironment-for-directed-tissue-formation
#10
Wollis J Vas, Mittal Shah, Rawiya Al Hosni, Helen C Owen, Scott J Roberts
Complications resulting from impaired fracture healing have major clinical implications on fracture management strategies. Novel concepts taken from developmental biology have driven research strategies towards the elaboration of regenerative approaches that can truly harness the complex cellular events involved in tissue formation and repair. Advances in polymer technology and a better understanding of naturally derived scaffolds have given rise to novel biomaterials with an increasing ability to recapitulate native tissue environments...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28228933/vascularization-and-innervation-of-slits-within-polydimethylsiloxane-sheets-in-the-subcutaneous-space-of-athymic-nude-mice
#11
Rachel E Gurlin, Mark T Keating, Shiri Li, Jonathan Rt Lakey, Sébastien de Feraudy, Bhupinder S Shergill, Elliot L Botvinick
Success of cell therapy in avascular sites will depend on providing sufficient blood supply to transplanted tissues. A popular strategy of providing blood supply is to embed cells within a functionalized hydrogel implanted within the host to stimulate neovascularization. However, hydrogel systems are not always amenable for removal post-transplantation; thus, it may be advantageous to implant a device that contains cells while also providing access to the circulation so retrieval is possible. Here we investigate one instance of providing access to a vessel network, a thin sheet with through-cut slits, and determine if it can be vascularized from autologous materials...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28228932/a-clinically-relevant-in-vivo-model-for-the-assessment-of-scaffold-efficacy-in-abdominal-wall-reconstruction
#12
Jeffrey Cy Chan, Krishna Burugapalli, Yi-Shiang Huang, John L Kelly, Abhay Pandit
An animal model that allows for assessment of the degree of stretching or contraction of the implant area and the in vivo degradation properties of biological meshes is required to evaluate their performance in vivo. Adult New Zealand rabbits underwent full thickness subtotal unilateral rectus abdominis muscle excision and were reconstructed with the non-biodegradable Peri-Guard(®), Prolene(®) or biodegradable Surgisis(®) meshes. Following 8 weeks of recovery, the anterior abdominal wall tissue samples were collected for measurement of the implant dimensions...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28717505/correction-impact-of-mechanical-stretch-on-the-cell-behaviors-of-bone-and-surrounding-tissues
#13
(no author information available yet)
[This corrects the article DOI: 10.1177/2041731415618342.].
January 2016: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28228931/tubular-organ-epithelialisation
#14
REVIEW
Rhea Saksena, Chuanyu Gao, Mathew Wicox, Achala de Mel
Hollow, tubular organs including oesophagus, trachea, stomach, intestine, bladder and urethra may require repair or replacement due to disease. Current treatment is considered an unmet clinical need, and tissue engineering strategies aim to overcome these by fabricating synthetic constructs as tissue replacements. Smart, functionalised synthetic materials can act as a scaffold base of an organ and multiple cell types, including stem cells can be used to repopulate these scaffolds to replace or repair the damaged or diseased organs...
January 2016: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28228930/optimal-conjugation-of-catechol-group-onto-hyaluronic-acid-in-coronary-stent-substrate-coating-for-the-prevention-of-restenosis
#15
Eugene Lih, Seul Gi Choi, Dong June Ahn, Yoon Ki Joung, Dong Keun Han
Although endovascular stenting has been used as an interventional therapy to treat cardio- and cerebro-vascular diseases, it is associated with recurrent vascular diseases following stent thrombosis and in-stent restenosis. In this study, a metallic stent was coated with dopamine-conjugated hyaluronic acid with different ratios of catechol group to improve hemocompatibility and re-endothelialization. Especially, we were interested in how much amount of catechol group is appropriate for the above-mentioned purposes...
January 2016: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28228929/decellularized-bone-matrix-grafts-for-calvaria-regeneration
#16
Dong Joon Lee, Shannon Diachina, Yan Ting Lee, Lixing Zhao, Rui Zou, Na Tang, Han Han, Xin Chen, Ching-Chang Ko
Decellularization is a promising new method to prepare natural matrices for tissue regeneration. Successful decellularization has been reported using various tissues including skin, tendon, and cartilage, though studies using hard tissue such as bone are lacking. In this study, we aimed to define the optimal experimental parameters to decellularize natural bone matrix using 0.5% sodium dodecyl sulfate and 0.1% NH4OH. Then, the effects of decellularized bone matrix on rat mesenchymal stem cell proliferation, osteogenic gene expression, and osteogenic differentiations in a two-dimensional culture system were investigated...
January 2016: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/27994846/hybrid-polyurea-elastomers-with-enzymatic-degradation-and-tunable-mechanical-properties
#17
Nicholas A Sears, Geraldine Pena-Galea, Stacy N Cereceres, Elizabeth Cosgriff-Hernandez
Herein, we report on the synthesis and characterization of enzymatically labile polyureas for use as a tissue-engineered ligament scaffold. Polyureas were selected due to their excellent tensile properties, fatigue resistance, and highly tunable nature. Incorporation of a collagenase-sensitive peptide into the backbone of the polyurea provided a means to confer cell-responsive degradation to the synthetic polymer. Chemical, morphological, and mechanical testing were used to confirm incorporation of the peptide and characterize polyurea films...
January 2016: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/27928496/bioactive-mesoporous-wollastonite-particles-for-bone-tissue-engineering
#18
S Saravanan, Nagarajan Selvamurugan
The current investigation was aimed at identifying the role of mesoporous wollastonite particles on the healing of rat tibial bone defect. The bone defect was created with a 3-mm-diameter dental drill, and it was filled with mesoporous wollastonite particles. After second and fourth weeks of filling treatments, it was found that mesoporous wollastonite particles promoted bone formation as evidenced by X-ray, histological, scanning electron microscope, and energy-dispersive spectra studies. X-ray study showed the closure of drill hole as seen by high-dense radio-opacity image...
January 2016: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/27895888/in-situ-formation-of-poly-vinyl-alcohol-heparin-hydrogels-for-mild-encapsulation-and-prolonged-release-of-basic-fibroblast-growth-factor-and-vascular-endothelial-growth-factor
#19
Justine J Roberts, Brooke L Farrugia, Rylie A Green, Jelena Rnjak-Kovacina, Penny J Martens
Heparin-based hydrogels are attractive for controlled growth factor delivery, due to the native ability of heparin to bind and stabilize growth factors. Basic fibroblast growth factor and vascular endothelial growth factor are heparin-binding growth factors that synergistically enhance angiogenesis. Mild, in situ encapsulation of both basic fibroblast growth factor and vascular endothelial growth factor and subsequent bioactive dual release has not been demonstrated from heparin-crosslinked hydrogels, and the combined long-term delivery of both growth factors from biomaterials is still a major challenge...
January 2016: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/27766141/multi-compartmental-biomaterial-scaffolds-for-patterning-neural-tissue-organoids-in-models-of-neurodevelopment-and-tissue-regeneration
#20
Richard J McMurtrey
Biomaterials are becoming an essential tool in the study and application of stem cell research. Various types of biomaterials enable three-dimensional culture of stem cells, and, more recently, also enable high-resolution patterning and organization of multicellular architectures. Biomaterials also hold potential to provide many additional advantages over cell transplants alone in regenerative medicine. This article describes novel designs for functionalized biomaterial constructs that guide tissue development to targeted regional identities and structures...
January 2016: Journal of Tissue Engineering
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