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American Journal of Cancer Research

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https://www.readbyqxmd.com/read/28560069/the-identification-and-validation-of-trichosstatin-a-as-a-potential-inhibitor-of-colon-tumorigenesis-and-colon-cancer-stem-like-cells
#1
Tse-Hung Huang, Szu-Yuan Wu, Yan-Jiun Huang, Po-Li Wei, Alexander Th Wu, Tsu-Yi Chao
Colon cancer is one of the most prevalent cancer types in developed countries. Metastasis and drug resistance are two contributing factors to the high mortality rate. Accumulating evidence suggest that cancer stem-like cells (CSCs) represents as a major contributor to these malignant features. Here, we identified and isolated colon cancer stem-like cells using side-population (SP) method from human colon cancer cell lines. SP colon cells demonstrate cancer stem-like cell properties including enhanced sphere-forming ability and resistance towards fluorouracil (5-FU)...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560068/hdac2-overexpression-correlates-with-aggressive-clinicopathological-features-and-dna-damage-response-pathway-of-breast-cancer
#2
Wenqi Shan, Yuanyuan Jiang, Huimei Yu, Qianhui Huang, Lanxin Liu, Xuhui Guo, Lei Li, Qingsheng Mi, Kezhong Zhang, Zengquan Yang
There are 18 lysine deacetylases, also known as histone deacetylases (HDACs), that remove acetyl groups from histone and non-histone proteins, thereby playing critical roles in numerous biological processes. In many human cancers, HDACs are dysregulated through mutation, altered expression, or inappropriate recruitment to certain loci. However, knowledge of the genomic and transcriptomic alterations and the clinical significance of most HDACs in breast cancer remain incomplete. We used TCGA and METABRIC datasets to perform comprehensive, integrated genomic and transcriptomic analyses of 18 HDAC genes in approximately 3000 primary breast cancers and identified associations among recurrent copy number alteration, gene expression, clinicopathological features, and patient survival...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560067/inhibition-of-hif-1%C3%AE-by-px-478-suppresses-tumor-growth-of-esophageal-squamous-cell-cancer-in-vitro-and-in-vivo
#3
Yingming Zhu, Yuanwei Zang, Fen Zhao, Zhenxiang Li, Jianbo Zhang, Liang Fang, Minghuan Li, Ligang Xing, Zhonghua Xu, Jinming Yu
The aim of this study is to investigate the clinical significance of hypoxia inducible factor-1α (HIF-1α) expression in esophageal squamous cell cancer (ESCC) and clarify the effects of PX-478, a selective HIF-1α inhibitor, on ESCC both in vitro and in vivo. HIF-1α, cyclooxygenase-2 (COX-2) and programmed death ligand-1 (PD-L1) were markedly overexpressed in ESCC tissue and associated with poorer survival. In vitro, both COX-2 and PD-L1 expression of ESCC cells were significantly induced by CoCl2 treatment, but inhibited by HIF-1α knock-down or PX-478 treatment...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560066/galnac-t6-in-the-relationship-with-invasion-ability-of-endometrial-carcinomas-and-prognostic-significance
#4
Thuy Thi Nguyen, Tomoko Kurita, Chiho Koi, Midori Murakami, Seiji Kagami, Toru Hachisuga, Hisaoka Masanori, Yasuo Morimoto, Hiroto Izumi
O-glycosylation in the field of carcinogenesis has been a critical topic of concern for several decades. The abnormal function of enzymes catalyzing the first step of this process, named polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) has been determined to play an important role in cancer development and metastasis. Accordingly, we investigated the expression of GalNAc-T6 in endometrial carcinoma and evaluated the relationship between invasion characteristics and the cellular level of GalNAc-T6...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560065/microrna-338-3p-inhibits-thyroid-cancer-progression-through-targeting-akt3
#5
Guo-Qing Sui, Dan Fei, Feng Guo, Xi Zhen, Qiang Luo, Shuai Yin, Hui Wang
microRNA-338-3p (miR-338-3p) has been implicated in tumor development and progression in many types of cancers. However, the function and mechanism underlying the action of miR-383-3p in thyroid cancer remain unclear and were therefore investigated in this study by in vitro and in vivo experiments. We found that miR-338-3p was downregulated in thyroid cancer tissues and cell lines. miR-338-3p expression was significantly associated with the clinical stage and lymph node metastasis of thyroid cancer. Forced expression of miR-338-3p suppressed thyroid cancer cell proliferation, clonogenicity, migration, and invasion in vitro and inhibited tumorigenesis in a nude mouse xenograft model system...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560064/fms-related-tyrosine-kinase-1-flt1-functions-as-an-oncogene-and-regulates-glioblastoma-cell-metastasis-by-regulating-sonic-hedgehog-signaling
#6
Kun Jiang, Yan-Ping Wang, Xiao-Dong Wang, Xiao-Bo Hui, Lian-Shu Ding, Ji Liu, Dai Liu
Studies have shown that the abnormal expression of Fms related tyrosine kinase 1 (Flt1) is associated with multiple malignancies, yet its role in glioblastoma pathology remains to be elucidated. In this study, we investigated the role of Flt1 in regulating proliferation, migration and invasion of glioblastoma cells by establishing glioblastoma cell strains with constitutively silenced or elevated Flt1 expression. We demonstrate that ectopic expression of Flt1 promotes glioblastoma cells migration, invasion through cell scratching and Transwell assays...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560063/ccr6-b-lymphocytes-responding-to-tumor-cell-derived-ccl20-support-hepatocellular-carcinoma-progression-via-enhancing-angiogenesis
#7
Huan He, Jianxiong Wu, Mengya Zang, Weihu Wang, Xiuli Chang, Xiangmei Chen, Ruijun Wang, Zhiyuan Wu, Liming Wang, Dongmei Wang, Fengmin Lu, Zongtang Sun, Chunfeng Qu
BACKGROUND & AIMS: Different immune cells in tumor microenvironment shape tumor progression. CCL20 over-expression was reported as one of the "stemness" trait in TP53 mutated hepatocellular carcinoma (HCC). We aimed to understand the effect of CCL20 on HCC progression. METHODS: In two HCC cohort patients (n=95, n=85 respectively), serum CCL20 concentration was quantified by using ELISA. Expressions of CCL20 and CCR6 in 41 paired HCC tumor and adjacent non-tumor tissues were determined by quantitative Real-Time PCR, confirmed by immunohistochemistry (CCL20) or by flow cytometry analysis (CCR6)...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560062/mir-146b-5p-regulates-cell-growth-invasion-and-metabolism-by-targeting-pdhb-in-colorectal-cancer
#8
Yuanzeng Zhu, Gang Wu, Wenfeng Yan, Han Zhan, Peichun Sun
MiRNA have been found to play a role in a plethora of cellular processes of cancer cells such as cell apoptosis, cell proliferation, invasion, migration metabolism and stem cell differentiation. Dysregulation of miR-146b-5p has been documented in a variety of human malignancies. However, the biological functions and molecular mechanisms of miR-146b-5p in ovarian cancer remain unknown. In this study, our results show that miR-146b-5p was unregulated in colorectal cancer (CRC) tissues compared with the adjacent non-cancerous tissues...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560061/understanding-tumor-anabolism-and-patient-catabolism-in-cancer-associated-cachexia
#9
Alejandro Schcolnik-Cabrera, Alma Chávez-Blanco, Guadalupe Domínguez-Gómez, Alfonso Dueñas-González
Cachexia is a multifactorial paraneoplastic syndrome commonly associated with advanced stages of cancer. Cachexia is responsible for poor responses to antitumoral treatment and death in close to one-third of affected patients. There is still an incomplete understanding of the metabolic dysregulation induced by a tumor that leads to the appearance and persistence of cachexia. Furthermore, cachexia is irreversible, and there are currently no guidelines for its diagnosis or treatments for it. In this review, we aim to discuss the current knowledge about cancer-associated cachexia, starting with generalities about cancer as the generator of this syndrome, then analyzing the characteristics of cachexia at the biochemical and metabolic levels in both the tumor and the patient, and finally discussing current therapeutic approaches to treating cancer-associated cachexia...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560060/microrna-365-inhibits-ovarian-cancer-progression-by-targeting-wnt5a
#10
Yanli Wang, Chunling Xu, Yun Wang, Xiaomeng Zhang
MicroRNA-365 (miR-365) has been reported to play an important role in tumorigenesis in many types of cancers; however, the role of miR-365 in the carcinogenesis of ovarian cancer remains unknown. In this study, we focused on the roles and underlying mechanisms of miR-365 in ovarian cancer. Here, we found that miR-365 expression level was significantly decreased in ovarian cancer tissues and cell lines, and that low miR-365 expression was negatively significantly associated with advanced stages as defined by the International Federation of Gynecology and Obstetrics (FIGO), histological grading, and lymph node metastasis...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560059/the-anti-protozoan-drug-nifurtimox-preferentially-inhibits-clonogenic-tumor-cells-under-hypoxic-conditions
#11
Quhuan Li, Qun Lin, Hoon Kim, Zhong Yun
Tumor hypoxia is an independent prognostic indicator of tumor malignant progression and poor patient survival. Therefore, eradication of hypoxic tumor cells is of paramount importance for successful disease control. In this study, we have made a new discovery that nifurtimox, a clinically approved drug to treat Chagas disease caused by the parasitic protozoan trypanosomes, can function as a hypoxia-activated cytotoxin. We have found that nifurtimox preferentially kill clonogenic tumor cells especially under the hypoxic conditions of ≤0...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560058/flot2-promotes-tumor-growth-and-metastasis-through-modulating-cell-cycle-and-inducing-epithelial-mesenchymal-transition-of-hepatocellular-carcinoma
#12
Cheng-Hao Wang, Xiao-Dong Zhu, De-Ning Ma, Hui-Chuan Sun, Dong-Mei Gao, Ning Zhang, Cheng-Dong Qin, Yuan-Yuan Zhang, Bo-Gen Ye, Hao Cai, Wen-Kai Shi, Man-Qin Cao, Zhao-You Tang
Flotillin-2 (Flot2) is a highly conserved and ubiquitously expressed protein that resides on the cytoplasmic side of the cell membrane within specific cholesterol rich microdomains. Some studies have reported that overexpression of Flot2 is related to cancer progression. However, the role of Flot2 in hepatocellular carcinoma (HCC) remains unclarified. In this study, we aim to explore the correlation between Flot2 expression and HCC progression and the underlying mechanism. In the present study, overexpression of Flot2 in HCC tissues and cell lines was detected, and forced overexpression of Flot2 significantly promoted the proliferation, migration, invasion and metastasis of HCC in vitro and in vivo by modulating cell cycle and inducing EMT, which was mediated via up-regulation of Twist as a result of Raf/MEK/ERK1/2 pathway activation...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560057/cebpa-mediated-upregulation-of-the-lncrna-plin2-promotes-the-development-of-chronic-myelogenous-leukemia-via-the-gsk3-and-wnt-%C3%AE-catenin-signaling-pathways
#13
Chengming Sun, Shuping Luan, Guili Zhang, Na Wang, Huiyuan Shao, Caifu Luan
Accumulating evidence has shown that long noncoding RNAs (lncRNAs) are significant regulators of multiple cellular processes, including the development of chronic myelocytic leukemia (CML). However, the mechanism of how the lncRNA PLIN2 affects CML development remains unclear. In this study, we aimed to investigate the potential roles of CEBPA-mediated upregulation of PLIN2 in the process of CML development by regulating the GSK3 and Wnt/β-catenin signaling pathways. We found that both CEBPA and PLIN2 were expressed at significantly higher levels in CML...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560056/maintaining-a-regular-physical-activity-aggravates-intramuscular-tumor-growth-in-an-orthotopic-liposarcoma-model
#14
Mohamad Assi, Frédéric Derbré, Luz Lefeuvre-Orfila, Dany Saligaut, Nathalie Stock, Mickael Ropars, Amélie Rébillard
Today, care teams within cancer centers encourage patients to be physically active, after diagnosis, based on data obtained mainly from breast, colon and prostate cancer. Intriguingly, the impact of physical activity (PA) on intramuscular tumors (e.g. sarcomas) has not been specifically addressed and, thus, could be mistakenly confounded with other cancers. In this preclinical study we assessed the impact of PA on intramuscular liposarcoma (LS) evolution. Four-week-old nude male mice were active by voluntary running on wheels, for six weeks...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28560055/revisiting-the-hallmarks-of-cancer
#15
REVIEW
Yousef Ahmed Fouad, Carmen Aanei
The hallmarks of cancer described by Hanahan and Weinberg have proved seminal in our understanding of cancer's common traits and in rational drug design. Not free of critique and with understanding of different aspects of tumorigenesis coming into clearer focus in the recent years, we attempt to draw a more organized and updated picture of the cancer hallmarks. We define seven hallmarks of cancer: selective growth and proliferative advantage, altered stress response favoring overall survival, vascularization, invasion and metastasis, metabolic rewiring, an abetting microenvironment, and immune modulation, while highlighting some considerations for the future of the field...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28469971/alpinumisoflavone-suppresses-tumour-growth-and-metastasis-of-clear-cell-renal-cell-carcinoma
#16
Tingting Wang, Yuhua Jiang, Lei Chu, Tianhui Wu, Jie You
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. The present study is aimed to investigate the role of alpinumisoflavone (AIF), a naturally occurring flavonoid compound, in ccRCC and the underlying mechanism. In this study, miR-101 has been identified as a novel therapeutic target, which exerts anti-tumor effect on ccRCC by directly targeting RLIP76. Moreover, our results showed that AIF was able to increase the expression of miR-101 by suppressing Akt signalling. Our findings in this study provided experimental evidence that AIF has the potential to be used as an agent in the treatment of ccRCC...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28469970/microrna-1301-inhibits-proliferation-of-human-glioma-cells-by-directly-targeting-n-ras
#17
Tongle Zhi, Kuan Jiang, Chuanzhuo Zhang, Xiupeng Xu, Weining Wu, Er Nie, Tianfu Yu, Xu Zhou, Zhongyuan Bao, Xin Jin, Junxia Zhang, Yingyi Wang, Ning Liu
Glioma is one of the most common, rapidly progressive and fatal brain tumors, and accumulating evidence shows that microRNAs (miRNAs) play important roles in the development of cancers, including glioma. Therapeutic applications of miRNAs in Ras-driven glioma have been proposed; however, their specific functions and mechanisms are poorly understood. Here, we report that miR-1301-3p directly targets the neuroblastoma Ras viral oncogene homolog (N-Ras) and functions as a tumor-suppressor in glioma. Quantitative reverse transcription-PCR was applied to detect the expression of miR-1301-3p in glioma specimens...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28469969/vessel-morphometric-parameters-correlation-with-histologic-grade-and-vegf-expression-in-oligodendroglioma
#18
Leah B Strickland-Marmol, Steven Brem, Amyn M Rojiani, Mumtaz V Rojiani
The contributions of histologic features including microvascular proliferation to the determination of malignancy in oligodendrogliomas remain uncertain. We have retrospectively performed morphometric assessments in 20 tumors histologically classified as well-differentiated (WHO Grade II, n=8) or anaplastic (WHO Grade III, n=12) oligodendrogliomas (WDO or AO). Quantitative studies utilized image analysis of double immunolabeled vasculature with anti CD34 with VIP chromogen (purple) and proliferating nuclei with anti MIB-1, using DAB (brown)...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28469968/the-selective-c-met-inhibitor-tepotinib-can-overcome-epidermal-growth-factor-receptor-inhibitor-resistance-mediated-by-aberrant-c-met-activation-in-nsclc-models
#19
Manja Friese-Hamim, Friedhelm Bladt, Giuseppe Locatelli, Uz Stammberger, Andree Blaukat
Non-small cell lung cancer (NSCLC) sensitive to first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) often acquires resistance through secondary EGFR mutations, including the T790M mutation, aberrant c-Met receptor activity, or both. We assessed the ability of the highly selective c-Met inhibitor tepotinib to overcome EGFR TKI resistance in various xenograft models of NSCLC. In models with EGFR-activating mutations and low c-Met expression (patient explant-derived LU342, cell line PC-9), EGFR TKIs caused tumors to shrink, but growth resumed upon cessation of treatment...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28469967/elevated-ascl2-expression-in-breast-cancer-is-associated-with-the-poor-prognosis-of-patients
#20
Hui Xu, Xi-Long Zhao, Xue Liu, Xu-Gang Hu, Wen-Juan Fu, Qian Li, Yan Wang, Yi-Fang Ping, Xia Zhang, Xiu-Wu Bian, Xiao-Hong Yao
Achaete scute-like 2 (ASCL2) is a member of the basic helix-loop-helix (bHLH) transcription factors, and is expressed mainly in intestinal stem cells under normal conditions. Recently, aberrantly elevated ASCL2 was detected in cancer tissues, but the clinical relevance of ASCL2 in breast cancers remains to be decided. In this study, we evaluated the expression of ASCL2 and its relationship to cancer progression in specimens from 191 cases of breast cancer patients with follow-up information. The results indicated that ASCL2 was highly expressed in cancer cells while it was undetectable in normal epithelial cells...
2017: American Journal of Cancer Research
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