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American Journal of Cancer Research

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https://www.readbyqxmd.com/read/30416863/uri-knockdown-induces-autophagic-flux-in-gastric-cancer-cells
#1
Fei Zhang, Xiaoxia Hu, Yu Gu, Huiqin Bian, Zhonghai Xu, Qian Wang, Jinnan Chen, Yaojuan Lu, Lichuan Sun, Qiping Zheng, Junxia Gu
URI, a member of the prefoldin family of molecular chaperones, functions in the regulation of nutrient-sensitive, mTOR-dependent transcription signaling pathways. Previous studies of several tumor types demonstrated that URI exhibits characteristics similar to those of an oncoprotein. URI has been shown as a mitochondrial substrate of S6 kinase 1 (S6K1), which acts to integrate nutrient and growth factor signals to promote cell growth and survival. Notably, the Akt/mTOR/p70S6K signaling pathway constitutes major negative regulatory mechanism of autophagy...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416862/the-oncogenic-role-of-mst3-in-human-gastric-cancer
#2
Kuo-Ting Lee, Chia-Lin Chang, Chung-Yen Li, Hsianglin Song, Yan-Shen Shan, Ming-Derg Lai
MST3 (mammalian STE20-like kinase) is one of the protein kinase of the GCK III subfamily STE 20, and is known to play a role in cell growth and apoptosis. Our laboratory has demonstrated that MST3 promotes tumorigenicity through the VAV2/Rac1 signal axis in breast cancer. In this report, we further investigated the potential oncogenic role of MST3 in gastric cancer. Examination of tissue samples from 101 gastric cancer patients revealed that higher expression of MST3 was observed in tumor part with immunohistochemistry...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416861/downregulated-mir-621-promotes-cell-proliferation-via-targeting-caprin1-in-hepatocellular-carcinoma
#3
Yao Zhang, Wei You, Haoming Zhou, Zhiqiang Chen, Guoyong Han, Xueliang Zuo, Long Zhang, Jindao Wu, Xuehao Wang
MicroRNAs (miRNAs) have been reported to play an essential role in tumor development and progression. However, the function of miR-621 in hepatocellular carcinoma (HCC) remains largely unexplored. In this study, we found that miR-621 was downregulated in the HCC specimens and cell lines, and lower expression of miR-621 indicated poor survival. Overexpression of miR-621 was shown to induce G0/G1 cell cycle arrest and inhibit cell proliferation in vitro and in vivo . Luciferase assays revealed that cell cycle-associated protein 1 (CAPRIN1) is a novel functional downstream target of miR-621...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416860/immunotherapy-strategy-of-egfr-mutant-lung-cancer
#4
Shaorong Yu, Delin Liu, Bo Shen, Meiqi Shi, Jifeng Feng
EGFR-mutant lung cancer is an important molecular subtype in Asia considering that almost 40%-50% of patients with lung adenocarcinoma in Asian carry the active EGFR mutaiton. People have greatly anticipated the efficacy of PD-1/PD-L1 monoclonal antibody in lung cancer treatment but anti-PD-1/PD-L1 treatment failed to positively affect these patients. The NCCN guidelines do not recommend immunotherapy to patients with NSCLC carrying EGFR mutation at present. However, the reason why EGFR-mutant lung cancer patients show poor response to anti-PD-1/PD-L1 treatment is still unknown...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416859/predictive-value-of-ercc1-ercc2-ercc4-and-glutathione-s-transferase-pi-expression-for-the-efficacy-and-safety-of-folfirinox-in-patients-with-unresectable-pancreatic-cancer
#5
Shun Tezuka, Makoto Ueno, Satoshi Kobayashi, Manabu Morimoto, Shinichi Ohkawa, Akane Hirotani, Yuichiro Tozuka, Satoshi Moriya, Yoshiyasu Nakamura, Yohei Miyagi, Makoto Sugimori, Shin Maeda
The platinum-based chemotherapy regimen FOLFIRINOX (leucovorin, fluorouracil, irinotecan, and oxaliplatin) is currently used as a standard treatment for patients with unresectable pancreatic cancer. FOLFIRINOX is associated with severe toxicities, including neutropenia, febrile neutropenia, and anorexia; however, there are currently no reliable biomarkers to predict its efficacy and safety. Several studies of patients with various cancers have shown that tumor expression of excision repair cross-complementing (ERCC) proteins and glutathione S-transferase Pi (GSTPi) correlates with the response to platinum-based chemotherapies...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416858/the-extrema-of-circulating-mir-17-are-identified-as-biomarkers-for-aggressive-prostate-cancer
#6
Greg Dyson, Batoul Farran, Susan Bolton, Douglas B Craig, Alan Dombkowski, Jennifer L Beebe-Dimmer, Isaac J Powell, Izabela Podgorski, Lance K Heilbrun, Cathryn H Bock
MicroRNAs (miRNAs) constitute short non-coding RNAs that can post-transcriptionally modulate the expression of many oncogenes and tumor suppressor genes engaged in key cellular processes. Deregulated serum miRNA signatures have been detected in various solid cancers including prostate cancer, suggesting that circulating miRNAs could function as non-invasive biomarkers of tumor emergence and progression. To determine whether serum miRNA expression levels are different between patients with aggressive and non-aggressive prostate cancer, we analyzed a panel of miRNAs from the blood of African American (AA) prostate cancer patients using a new recursive partitioning method that allows hypothesis testing of each split...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416857/abnormal-expression-of-yeats4-associates-with-poor-prognosis-and-promotes-cell-proliferation-of-hepatic-carcinoma-cell-by-regulation-the-tcea1-ddx3-axis
#7
Song You, Fuqiang Wang, Qing Hu, Pengtao Li, Changmao Zhang, Yaqi Yu, Yi Zhang, Qiu Li, Qing Bao, Pingguo Liu, Jie Li
YEATS domain containing 4 (YEATS4) is usually amplified and functions as an oncogene in several malignancies, such as colorectum, ovarian, breast and lung. However, the biological role of YEATS4 in hepatocellular carcinoma (HCC) has not yet been discussed. Herein, we found that YEATS4 was significantly upregulated in HCC compared to para-cancerous tissues, and was associated with poor prognosis, large tumor size, poor differentiation and distant metastasis. In addition, YEATS4 promoted HCC cell proliferation and colony formation by binding to and increasing the transcriptional activity of the TCEA1 promoter...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416856/monepantel-considerably-enhances-the-therapeutic-potentials-of-pegylated-liposomal-doxorubicin-and-gemcitabine-in-ovarian-cancer-in-vitro-and-in-vivo-studies
#8
Parvin Ataie-Kachoie, Krishna Pillai, Samina Badar, Javed Akhter, David Lawson Morris
Ovarian cancer is a lethal disease since treated patients often die from relapse. Resistance to current treatment regime involving doxorubicin and gemcitabine is well known. Hence, we set forth to develop a more effective therapy by combining current treatment drugs with monepantel, an antihelminth drug with proven anticancer effect. In vitro cytotoxicity were first investigated with pegylated liposomal doxorubicin (PLD), gemcitabine, monepantel as single agents and then in combination with monepantel on ovarian tumor cells...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416855/vegf-c-flt-4-axis-in-tumor-cells-contributes-to-the-progression-of-oral-squamous-cell-carcinoma-via-upregulating-vegf-c-itself-and-contactin-1-in-an-autocrine-manner
#9
Seiji Shigetomi, Yorihisa Imanishi, Katsushi Shibata, Nobuya Sakai, Koji Sakamoto, Ryoichi Fujii, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Masayuki Shimoda, Kaori Kameyama, Hiroyuki Ozawa, Toshiki Tomita, Kaoru Ogawa
Tumor cell-derived vascular endothelial growth factor (VEGF)-C has been primarily implicated in promoting lymphangiogenesis by activating Flt-4 (VEGFR-3) expressed on lymphatic endothelial cells via a paracrine mechanism. Flt4 has also been shown to be expressed selectively in subsets of cancer cells. However, little is known about the functional role of VEGF-C/Flt4 signaling via an autocrine mechanism, as well as the clinicopathological implication of the VEGF-C/Flt4 axis and its downstream effector molecules, in head and neck squamous cell carcinoma (HNSCC), including oral squamous cell carcinoma (OSCC)...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416854/brms1-coordinates-with-lsd1-and-suppresses-breast-cancer-cell-metastasis
#10
Rongfang Qiu, Hang Shi, Shuang Wang, Shuai Leng, Ruiqiong Liu, Yu Zheng, Wei Huang, Yi Zeng, Jie Gao, Kai Zhang, Yongqiang Hou, Dandan Feng, Yang Yang
Breast carcinoma metastasis suppressor gene 1 ( BRMS1 ) encodes an inhibitor of metastasis and is reported in many types of tumor metastasis. However, the mechanism of BRMS1-mediated inhibition of breast cancer metastasis at the transcriptional level remains elusive. Here, we identified using affinity purification and mass spectrometry (MS) that BRMS1 is an integral component of the LSD1/CoREST corepressor complex. Analysis of the BRMS1/LSD1 complex using high-throughput RNA deep sequencing (RNA-seq) identified a cohort of target genes such as VIM, INSIG2, KLK11, MRPL33, COL5A2, OLFML3 and SLC1A1 , some of which are metastasis-related...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416853/long-non-coding-rna-linc01296-promotes-esophageal-squamous-cell-carcinoma-cell-proliferation-and-invasion-by-epigenetic-suppression-of-klf2
#11
Luming Wang, Di Meng, Yiqing Wang, Jian Hu
Dysregulated long non-coding RNAs (lncRNAs) are found in many types of tumors, including esophageal squamous cell carcinoma (ESCC); however, the pattern of expression and function of LINC01296 in esophageal squamous cell carcinoma are unknown. In the current study we showed that LINC01296 expression is significantly higher in ESCC tissues when compared with corresponding adjacent normal tissues. Higher LINC01296 expression was associated with lymph node metastasis, TNM stage, and worse overall survival rate in ESCC patients...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416852/novel-nano-drug-combination-therapeutic-regimen-demonstrates-significant-efficacy-in-the-transgenic-mouse-model-of-pancreatic-ductal-adenocarcinoma
#12
Arvind Thakkar, Preshita Desai, Sushma Chenreddy, Jalpa Modi, Astrid Thio, Wael Khamas, David Ann, Jeffrey Wang, Sunil Prabhu
The current work studied the chemopreventive efficacy of orally administered chitosan coated solid-lipid nanoparticle (c-SLN) encapsulated aspirin (ASP), curcumin (CUR) and free sulforaphane (SFN), ACS-cSLN, in the LSL-Kras G12D/ + ; Pdx-1 Cre/ + transgenic mouse model of pancreatic ductal adenocarcinoma (PDAC). In vitro uptake study and intracellular localization of ODA-FITC labeled ASP and CUR c-SLNs were performed in Panc-1 and MIA PaCa-2 cells by fluorescence microscopy. LSL-Kras G12D/ + ; Pdx-1 Cre/ + transgenic mice (n = 30) were randomly divided into 5 groups...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416851/foxa1-transcriptionally-up-regulates-cyclin-b1-expression-to-enhance-chondrosarcoma-progression
#13
Zong-Shin Lin, Chiao-Chen Chung, Yu-Chia Liu, Tsung-Ming Chen, Yung-Luen Yu, Shao-Chun Wang, Ya-Huey Chen
Chondrosarcoma is a malignant and common bone tumor that is highly resistant to radiation and chemotherapy. At this moment, amputation surgery is the only option which unfortunately has serious impact to daily lives of the patients. Thus, there is an urgent need to understand causative molecular mechanisms underlying the disease for more accurate prognosis and more effective targeted treatment. In the current study, we identify the transcription factor FOXA1 through cDNA microarray screening comparing normal versus chondrosarcoma cells and investigate the mechanisms underlying its function in chondrosarcoma development...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416850/mismatch-repair-based-stratification-for-immune-checkpoint-blockade-therapy
#14
REVIEW
Lihong Zhang, Yang Peng, Guang Peng
Mismatch repair (MMR) plays a key role in maintaining genomic stability. Mismatch repair deficiency (MMR-D) causes a molecular feature of microsatellite instability (MSI) and contributes to the development of human cancers and genetic diseases with cancer predisposition such as Lynch syndrome. Recent studies have shown that immune checkpoint blockade therapy has a promising response in MMR-D cancers regardless of the tissue of origin. Being able to identify patients with MMR-D cancers is an important challenge in clinical practice...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416849/an-overview-of-mct1-and-mct4-in-gbm-small-molecule-transporters-with-large-implications
#15
REVIEW
Simon J Park, Chase P Smith, Ryan R Wilbur, Charles P Cain, Sankeerth R Kallu, Srijan Valasapalli, Arpit Sahoo, Maheedhara R Guda, Andrew J Tsung, Kiran K Velpula
Monocarboxylate transporters (MCTs) represent a diverse group of transmembrane proteins encoded by the SLC16 gene family found ubiquitously across mammalian species. Two members of this family, MCT1 and MCT4, have been linked to key roles in the metabolic activity of tissues through the proton-coupled transport of monocarboxylates, most notably L-lactate, ketone bodies, and pyruvate. This review aims to provide an overview of MCT1 and MCT4, followed by the implications of their expression in a multitude of cancers and in glioblastoma (GBM) specifically...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416848/n6-methyladenine-rna-modification-and-cancers
#16
REVIEW
Xia Wu, Lina Sang, Yuping Gong
Similar to DNA methylation modifications, N6-methyladenine (m6 A) has been identified as a dynamic and reversible modification in messenger RNA (mRNA), regulated by m6 A methyltransferases and demethylases. m6 A modifications regulate gene expressions and play vital roles in many life processes. Some proteins serve as m6 A-binding proteins to perform the m6 A-modified biological functions. Recently, m6 A modifications have been reported to play critical roles in human cancers, including lung cancer, brain tumor, leukemia, and many others...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416847/promising-clinical-application-of-ctdna-in-evaluating-immunotherapy-efficacy
#17
REVIEW
Li Li, Jun Zhang, Xiaoyue Jiang, Qin Li
An increasing number of promising immunotherapies and related clinical trials have led to several major breakthroughs in multiple cancers, but a reliable and precise biomarker for evaluating efficacy and prognosis has not yet been established. As a typical representation of a liquid biopsy, circulating cell-free DNA (ctDNA) possesses the functions and advantages of tissue biopsy but its distinct advantages of convenience, real-time nature, non-invasiveness and homogeneity make it superior to tissue biopsy. Indeed, compared with routine imaging and tumor markers, ctDNA offers an earlier indication and provides more precise information...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416846/iron-and-magnetic-new-research-direction-of-the-ferroptosis-based-cancer-therapy
#18
REVIEW
Shenghang Wang, Jie Luo, Zhihao Zhang, Dandan Dong, Ying Shen, Yanwen Fang, Lijiang Hu, Mengyu Liu, Chengfu Dai, Songlin Peng, Zhicai Fang, Peng Shang
Ferroptosis is an iron depend cell death which caused by lipid peroxidation. Abnormal iron metabolism and high intracellular iron content are the characteristics of most cancer cells. Iron is a promoter of cell growth and proliferation. However, iron also could take part in Fenton reaction to produce reactive oxygen species (ROS). The intercellular ROS could induce lipid peroxidation, which is necessary for ferroptosis. Iron metabolism mainly includes three parts: iron uptake, storage and efflux. Therefore, iron metabolism-related genes could regulate intercellular iron content and status, which can be involved ferroptosis...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416845/the-emerging-role-of-circular-rnas-in-gastric-cancer
#19
REVIEW
Peina Shi, Jiangnan Wan, Haojun Song, Xiaoyun Ding
Gastric cancer (GC) ranks as the fourth most common cancer and the third leading cause of cancer-related death worldwide. Circular RNAs (circRNAs) are a new class of long noncoding RNAs characterized by a single-stranded covalently closed loop structure. Emerging evidence reveals the essential function of circRNAs in the occurrence and development of human diseases. Among these, circRNAs are aberrantly expressed in GC and are involved in the progression of GC. In this review, we briefly summarize the current knowledge of the classification, biogenesis and biological functions of circRNAs, with an emphasis on their relationship with GC...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/30416844/optogenetics-the-new-molecular-approach-to-control-functions-of-neural-cells-in-epilepsy-depression-and-tumors-of-the-central-nervous-system
#20
REVIEW
Bruno Camporeze, Bruno Alcântara Manica, Gabriel Alves Bonafé, Jivago Jordão Camargos Ferreira, Aurélio Lourenço Diniz, Carlos Tadeu Parisi de Oliveira, Luis Roberto Mathias Junior, Paulo Henrique Pires de Aguiar, Manoela Marques Ortega
The optogenetic tools have been described as valuable techniques to study neural activity through light stimulation, as well as potential neuromodulator approaches in the management of several central nervous system (CNS) diseases. Since the first bacteriorhodopsin protein described as a single-component light-activated regulator of transmembrane ion flow description, in 1980's, the focus has been on channel proteins for neurobiology; however, the advances in engineering techniques showed involvement changes in cellular biological behavior in several types of proteins involved in cell cytoskeleton regulation, motility and gene expression...
2018: American Journal of Cancer Research
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