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American Journal of Cancer Research

Krittiya Korphaisarn, Chao-Kai Chou, Wei-Ya Xia, Callisia N Clarke, Riham Katkhuda, Jennifer S Davis, Kanwal Ps Raghav, Hsin-Wei Liao, Ji-Yuan Wu, David G Menter, Dipen M Maru, Mien-Chie Hung, Scott Kopetz
Arginine methylation of the epidermal growth factor receptor (meEGFR) increases the binding affinity of EGFR ligands and is reported to have a role in predicting response to anti-EGFR agents. This study investigated the predictive impact of meEGFR in metastatic colorectal cancer (mCRC) patients treated with anti-EGFR agents. Two patient cohorts were evaluated. Cohort 1 consisted of mCRC patients with documented disease progression following anti-EGFR treatment. Circulating tumor cells (CTCs) were isolated and distinguished based on CD45- and Epcam+...
2017: American Journal of Cancer Research
Kazuaki Matsuoka, Teiji Takechi
Trifluridine/tipiracil (FTD/TPI or TFTD, also known as TAS-102) with a molar ratio of 1:0.5, is a novel combination of FTD, an antineoplastic thymidine analog, and TPI, an inhibitor of thymidine phosphorylase. It has been approved as a treatment for unresectable advanced or recurrent colorectal cancer. Irinotecan (CPT-11) is an active agent in colorectal cancer. The administration order of drugs is a critical issue in clinical combination therapy. In this study, we evaluated the in vitro simultaneous and sequential combination efficacy of FTD and SN-38, an active metabolite of CPT-11, against human colorectal 5-fluorouracil (5-FU) resistant cell line DLD-1/5-FU and the parental cells DLD-1...
2017: American Journal of Cancer Research
Peter J Esau, Elizabeth M Gittemeier, Alexander B Opoku-Acheampong, Korynne S Rollins, Dryden R Baumfalk, David C Poole, Timothy I Musch, Bradley J Behnke, Steven W Copp
Exercise capacity is reduced in prostate cancer patients concurrently treated with androgen deprivation therapy compared to healthy counterparts. We tested the hypothesis that prostate cancer independently reduces endurance exercise capacity in a preclinical orthotopic prostate tumor model. Male Copenhagen rats performed an initial treadmill running test to exhaustion. The rats' prostates were subsequently injected with either prostate tumor cells (R-3327 AT-1, tumor bearing, n=9) or vehicle control (sham, n=9) and the treadmill tests were repeated four and eight weeks post-surgery...
2017: American Journal of Cancer Research
Haolei Tan, Gangcai Zhu, Li She, Ming Wei, Yunyun Wang, Leiming Pi, Changhan Chen, Diekuo Zhang, Pingqing Tan, Jie Chen, Donghai Huang, Yongquan Tian, Yong Liu, Xin Zhang
PURPOSE: MicroRNAs function through regulating specific target mRNA expression and then participate in the development and progression of diverse human cancers. MiR-98 shows aberrant expression and dysfunction in tumors. However, its clinical significance and exact role in squamous cell carcinoma of the head and neck (SCCHN) remain elusive. METHODS: MiR-98 expression was examined by qRT-PCR and correlated with clinicopathological variables and prognosis in SCCHN patients...
2017: American Journal of Cancer Research
Yanjun Xu, Rui Hou, Qijie Lu, Yang Zhang, Lei Chen, Yuanyi Zheng, Bing Hu
MicroRNA-491-5p (miR-491-5p) has been implicated in several cancers; however, its role in human prostate cancer (PCa) remains unknown. In this study, we observed downregulation of miR-491-5p expression in PCa tissues and cell lines. CCK-8 and EdU assays showed that forced expression of miR-491-5p suppressed PCa cell proliferation, which was further confirmed in a cell cycle assay. Overexpression of miR-491-5p also reduced PCa cell migration and invasion abilities as indicated by Transwell assays. Additionally, miR-491-5p overexpression significantly inhibited PCa growth in a mouse xenograft model...
2017: American Journal of Cancer Research
Li-Guo Zhang, Xin-Ke Zhou, Ru-Jian Zhou, Hui-Zeng Lv, Wei-Peng Li
Increasing evidence demonstrates abnormal expression of long non-coding RNA (lncRNA) is closely correlated with various malignancies including hepatocellular carcinoma (HCC). The present study aims to investigate the role of lncRNA long intergenic noncoding RNA 00673 (LINC00673) in tumorigenesis of HCC. Quantitative real-time polymerase chain reaction (qRT-PCR) revealed LINC00673 was upregulated in HCC cancerous tissue and cell lines compared to adjacent normal tissue and normal liver cell lines. LINC00673 overexpression is associated with poor prognosis and low survival rate...
2017: American Journal of Cancer Research
Hailin Zhang, Ming Bai, Ang Zeng, Loubin Si, Nanze Yu, Xiaojun Wang
Long non-coding RNAs (lncRNAs) act as critical regulators of many malignant tumors cellular processes including cell proliferation, differentiation, apoptosis, invasion and metastasis. However, the functions and molecular mechanisms of lncRNA HOXD-AS1 in melanoma remain little known. In the present study, we observed that lncRNA HOXD-AS1 expression was remarkably higher in melanoma tissues compared to skin tissues with melanocytic nevus. Increased expression of lncRNA HOXD-AS1 correlated with poor survival of melanoma patients...
2017: American Journal of Cancer Research
Guanghua Liu, Zixing Ye, Xin Zhao, Zhigang Ji
Clear cell renal cell carcinoma (ccRCC) is one of the leading causes of genitourinary cancer-related death, largely due to the metastasis of ccRCC. Previous profiling study showed that lncRNAs are critical regulators in lots of cancers. However, the roles of specific lncRNAs in ccRCC migration and invasion are still unknown. In this study, we utilized the high-throughput genome sequencing to identify the potential differentially expressed lncRNAs in ccRCC and further determined the underlying regulatory mechanism...
2017: American Journal of Cancer Research
Wanhu Zhu, Qing Liang, Xu Yang, Yan Yu, Xiaoying Shen, Guangchun Sun
Sorafenib is currently the only approved first-line targeted drug against advanced hepatocellular carcinoma (HCC). However, unsatisfactory efficacy and resistance of sorafenib raises the urgent need to develop more effective therapeutic strategies for HCC. Here, we evaluated the effects of combination of histone deacetylase inhibitor Valproic acid (VPA) and sorafenib in HCC both in vitro and in vivo. Co-treatment of sorafenib and VPA synergistically inhibited HCC cell viability, induced cell apoptosis, along with the up-regulation of p21, Bax, cleaved caspase9, cleaved caspase3, cleaved PARP and down-regulation of Bcl-xL, suggesting this combination activated intrinsic apoptotic pathway...
2017: American Journal of Cancer Research
Chao Jing, Xin Qu, Zhaoqing Li, Chuanqiang Wu, Minghui Zhao, Yu Wang, Shanshan Sun, Shengchi Zhang, Jinliang Chen, Yu Qiao, Xiaomeng Hu, Xiaofeng Yao, Rui Jin, Xudong Wang, Lun Zhang, Xuan Zhou
Patients suffered from head and neck squamous cell carcinoma (HNSCC) have an overall poor prognosis owing to proliferation and resistance to treatment. Hence, mining the underlying mechanism of malignancies above and translating the bench outcomes to clinical practice are in urgent need. Previous studies found that the epidermal growth factor receptor (EGFR) increases and co-expresses with EGFRvIII in HNSCC tissues, which indicates poor prognosis of HNSCC patients. Here, we clarify that compared with EGFRwt, EGFRwt/vIII enhances the capability of proliferation and colony formation in HNSCC cells in vitro, and reduces the sensitivity to cisplatin...
2017: American Journal of Cancer Research
Hannah M Jones, Ziwei Fang, Wenchuan Sun, Leslie H Clark, Jessica E Stine, Arthur-Quan Tran, Stephanie A Sullivan, Timothy P Gilliam, Chunxiao Zhou, Victoria L Bae-Jump
Ovarian cancer is the 8th most common cancer in women, and the 5th leading cause of cancer-related deaths among women in the United States. Statins have been shown to have promising anti-tumorigenic activity in many types of cancers. We sought to determine the effects of atorvastatin (ATO) on cell proliferation in ovarian cancer and identify the mechanisms by which ATO inhibits cell growth in this disease. ATO inhibited cell proliferation of both the Hey and SKOV3 ovarian cancer cells in a dose-dependent manner...
2017: American Journal of Cancer Research
Ping-Ting Gao, Jian-Wen Cheng, Zi-Jun Gong, Bo Hu, Yun-Fan Sun, Ya Cao, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Xin-Rong Yang
Overall survival of patients with hepatocellular carcinoma (HCC) remains poor, and the multidrug resistance of HCC cells contributes to the limited efficacy of anti-cancer drugs, and reduced time to recurrence. We systematically screened the expression of transporter genes in HCC samples and found that solute carrier family 29 member A1 (SLC29A1) expression was significantly elevated in human HCC cells compared with para-carcinoma cell samples. The results of tissues microarray showed that SLC29A1 was an independent prognostic factor for overall survival and tumor recurrence, especially for patients with AFP ≤ 20 ng/ml, no microvascular invasion and early staging...
2017: American Journal of Cancer Research
Niroshaathevi Arumuggam, Nicole Melong, Catherine Kl Too, Jason N Berman, Hp Vasantha Rupasinghe
The overall clinical outcome in T-cell acute lymphoblastic leukemia (T-ALL) can be improved by minimizing risk for treatment failure using effective pharmacological adjuvants. Phloridzin (PZ), a flavonoid precursor found in apple peels, was acylated with docosahexaenoic acid (DHA) yielding a novel ester known as phloridzin docosahexaenoate (PZ-DHA). Here, we have studied the cytotoxic effects of PZ-DHA on human leukemia cells using in vitro and in vivo models. The inhibitory effects of PZ-DHA were tested on human Jurkat T-ALL cells in comparison to K562 chronic myeloid leukemia (CML) cells and non-malignant murine T-cells...
2017: American Journal of Cancer Research
Lin-Xin Zhang, Lu Xu, Chen-Han Zhang, Yi-Han Lu, Tian-Hao Ji, Li-Jun Ling
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 bp with no protein-coding capacity. Transcribed ultraconserved regions (T-UCRs) are a type of lncRNA and are conserved among human, chick, dog, mouse and rat genomes. These sequences are involved in cancer biology and tumourigenesis. Nevertheless, the clinical significance and biological mechanism of T-UCRs in breast cancer remain largely unknown. The expression of uc.38, a T-UCR, was down-regulated in both breast cancer tissues and breast cancer cell lines...
2017: American Journal of Cancer Research
Holli A Loomans, Shanna A Arnold, Kate Hebron, Chase J Taylor, Andries Zijlstra, Claudia D Andl
Squamous cell carcinomas of the head and neck (HNSCC) and esophagus (ESCC) pose a global public health issue due to high mortality rates. Unfortunately, little progress has been made in improving patient outcomes. This is partially a result of a lack of understanding the mechanisms that drive SCC progression. Recently, Activin A signaling has been implicated in a number of cancers, yet the role of this pathway in SCC remains poorly understood. We have previously discovered that the Activin A ligand acts as a tumor suppressor when epithelial Activin receptor type IB (ACVRIB) is intact; however, this effect is lost upon ACVRIB downregulation...
2017: American Journal of Cancer Research
Xiulei Zhang, Qinyue Chen, Meiyu Chen, Xiaoqing Ren, Xiaofei Wang, Jianghui Qian, Yali Sun, Xianyi Sha
Lung carcinoma has become a more and more serious health problem as platinum-based chemotherapy remains a limited benefit. Accumulating evidences indicate that autophagy plays a significant role in decreased curative effect and chemotherapy failure. Inhibition of autophagy can potentiate anti-proliferation effect and contribute to tumor regression in lung carcinoma. Here, we showed that the expectorant drug ambroxol (Ax) promoted autophagosomes accumulation by blocking late-stage autophagic flux in lung carcinoma cells...
2017: American Journal of Cancer Research
Xuedong Fu, Wei Liu, Qian Huang, Yanjun Wang, Huijuan Li, Ying Xiong
The clinical management of pediatric acute lymphoblastic leukemia (ALL) is still changeling and identification of agents that can sensitize standard chemotherapy is needed for its better management. In this work, we demonstrate that tigecycline, a FDA-approved antibiotic, is an attractive candidate for ALL treatment. Tigecycline inhibits growth and induces apoptosis of multiple ALL cell lines. Compared to normal hematopoietic cells, tigecycline is more active against primary lymphocytes and CD34 progenitors from ALL patients through decreasing survival and clonogenic growth...
2017: American Journal of Cancer Research
Fengzhi Li, Tao Jiang, Qingyong Li, Xiang Ling
Camptothecin (CPT) was discovered from plant extracts more than 60 years ago. Since then, only two CPT analogues (irinotecan and topotecan) have been approved for cancer treatment, although several thousand CPT derivatives have been synthesized and many of them were actively studied in our research community over the past 6+ decades. In this review article, we briefly summarize: (1) the discovery and early development of CPTs, (2) the recognized CPT mechanism of action (MOA), (3) the synthesis of CPT and CPT analogues, and (4) the structure-activity relationship (SAR) of CPT and its analogues...
2017: American Journal of Cancer Research
Vincent Crenn, Kevin Biteau, Jérôme Amiaud, Clotilde Dumars, Romain Guiho, Luciano Vidal, Louis-Romée Le Nail, Dominique Heymann, Anne Moreau, François Gouin, Françoise Redini
Osteosarcoma, the most common malignant primary bone tumor, is currently treated with chemotherapy and surgery. The effectiveness of chemotherapy is evaluated by means of histological analysis of tumor necrosis, known as "the Huvos score". However, 25% of the patients initially considered good responders will relapse. In our practice, strong tissue heterogeneity around the residual viable cells of the osteosarcoma is observed, but this is not taken into account by the Huvos score, as it is only an average. The objective is to determine whether heterogeneity in the osteosarcoma's microenvironment can play a role in the histological response to chemotherapy...
2017: American Journal of Cancer Research
Tian Lu, Jinming Li
Liquid biopsy is gaining significant attention as a tool for unveiling the molecular landscape of tumor and holds great promise for individualized medicine for cancer. Cell-free DNA serves as an extremely important component of liquid biopsy for cancer, and cell-free DNA in urine is even promising due to the remarkable advantage of urine as an ultra-noninvasive sample source over tissue and blood. Compared with the widely studied cell-free DNA in blood, less is known about the role of urinary cell-free DNA...
2017: American Journal of Cancer Research
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