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Innovations in Clinical Neuroscience

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https://www.readbyqxmd.com/read/30013819/atrial-fibrillation-and-injected-aripiprazole-a-case-report
#1
Anthi Stefatos, Julie N Ha, Adrian Baranchuk, Ross J Baldessarini, Gustavo H Vázquez
Background: Aripiprazole is a widely clinically employed antipsychotic drug for a range of indications. It has unusual pharmacodynamics as a dopamine D2 receptor partial-agonist with complex interactions with serotonin receptors and, a relatively unusual long elimination half-life. Although other atypical antipsychotics have been associated with an increased risk of atrial fibrillation, aripiprazole is considered to be relatively neutral in regard to its cardiac risk. We report a case of a 45-year-old Caucasian patient with schizoaffective disorder who developed acute atrial fibrillation (AF) several days after an intramuscular injection of a large long-acting dose of the drug after low oral doses had been well-tolerated...
June 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/30013818/development-of-a-behavioral-health-stigma-measure-and-application-of-machine-learning-for-classification
#2
REVIEW
Farah Tokmic, Mirsad Hadzikadic, James R Cook, Oleg V Tcheremissine
Objective: Given the growing public health importance of measuring the change in mental health stigma over time, the goal of this study was to demonstrate the potential for using machine learning as a tool to analyze patterns of social stigma as a complement to traditional research methods. Methods: A total of 1,904 participants were recruited through Sona Systems, Ltd (Tallinn, Estonia), an experiment management system for online research, to complete a self-reported survey. The collected data were used to develop a new measure of mental (behavioral) health stigma...
June 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/30013817/delirium-and-psychotic-symptoms-associated-with-hyperglycemia-in-a-patient-with-poorly-controlled-type-2-diabetes-mellitus
#3
Rui Lopes, Bernardo Dias Pereira
Delirium, acute confusional states, and secondary psychosis have been associated with several medical conditions, including endocrine disorders. In the context of diabetes mellitus (DM), it has been mostly related to hypoglycemia and rarely occurs in association with hyperglycemia, outside of the context of a hyperglycemic hyperosmolar state or diabetic ketoacidosis. Here, we describe a case of delirium and psychotic symptoms associated with hyperglycemia in a patient with poorly controlled Type 2 DM as an attempt to alert clinicians to this rare association...
June 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/30013816/effects-of-lisdexamfetamine-dimesylate-on-functional-impairment-measured-on-the-sheehan-disability-scale-in-adults-with-moderate-to-severe-binge-eating-disorder-results-from-two-randomized-placebo-controlled-trials
#4
David V Sheehan, Maria Gasior, Susan L McElroy, Jana Radewonuk, Barry K Herman, James Hudson
Objective: In two Phase III, randomized, placebo-controlled trials (NCT01718483 and NCT01718509 at ClinicalTrials.gov), lisdexamfetamine dimesylate (LDX) reduced binge eating days/week in adults with moderate-to-severe binge eating disorder (BED). We describe the effects of LDX (50mg and 70mg) on the Sheehan Disability Scale (SDS; exploratory endpoint) from both studies. Design: The SDS was assessed at baseline, Week 6, and Week 12/early termination. Analyses included mixed-effects models for repeated measures for the examination of SDS total and domain score changes and a generalized estimating equation model to assess dichotomized remission status (remission [total score ≤6] versus nonremission [total score >6])...
June 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/30013815/combination-phentermine-topiramate-extended-release-for-the-treatment-of-binge-eating-disorder-an-open-label-prospective-study
#5
Anna I Guerdjikova, Stephanie Williams, Thomas J Blom, Nicole Mori, Susan L McElroy
Objective: The goal of this study was to obtain preliminary data on the usefulness of the combination of phentermine and topiramate extended release (phentermine-topiramate) in binge-eating disorder (BED) associated with obesity or overweight. Design: Ten participants with BED and obesity or overweightness with at least one weight-related complication received phentermine-topiramate in an open-label, prospective, 12-week trial. The primary outcome measure was change in weight. The study was registered under the identifier NCT02659475 at ClinicalTrials...
June 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/30013814/valbenazine-and-deutetrabenazine-for-tardive-dyskinesia
#6
REVIEW
Katie T B Touma, Jonathan R Scarff
Tardive dyskinesia (TD) is a medication-induced permanent movement disorder with no United States Food and Drug Administration (FDA)-approved treatments prior to 2017. Although TD is medication-induced, patients who have responded well to antipsychotics might not be candidates for dose reduction or discontinuation due to a risk of psychiatric decompensation. Valbenazine and deutetrabenazine were recently approved by the FDA for the treatment of TD. They offer a unique mechanism of action by inhibiting vesicular monoamine transporter type 2...
June 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/30013813/effective-pain-control-in-hutchinson-gilford-progeria-syndrome
#7
Muhammad Hassan Majeed, Muhammad Ubaidulhaq, William E Gusa
No abstract text is available yet for this article.
June 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/30013812/kratom-and-the-opioid-crisis
#8
Durga Bestha
No abstract text is available yet for this article.
June 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29721364/audio-recording-for-independent-confirmation-of-clinical-assessments-in-generalized-anxiety-disorder
#9
Steven D Targum, Christopher Murphy, Jibran Khan, Laura Zumpano, Mark Whitlock, Arthur A Simen, Brendon Binneman
Objective : The assessment of patients with generalized anxiety disorder (GAD) to deteremine whether a medication intervention is necessary is not always clear and might benefit from a second opinion. However, second opinions are time consuming, expensive, and not practical in most settings. We obtained independent, second opinion reviews of the primary clinician's assessment via audio-digital recording. Design : An audio-digital recording of key site-based assessments was used to generate site-independent "dual" reviews of the clinical presentation, symptom severity, and medication requirements of patients with GAD as part of the screening procedures for a clinical trial (ClinicalTrials...
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29707426/is-electroconvulsive-therapy-a-treatment-for-depression-following-traumatic-brain-injury
#10
Anja Srienc, Puneet Narang, Simrat Sarai, Yee Xiong, Steven Lippmann
Traumatic brain injury (TBI) can be caused by blunt or penetrating injury to the head. The pathophysiological evolution of TBI involves complex biochemical and genetic changes. Common sequelae of TBI include seizures and psychiatric disorders, particularly depression. In considering pharmacologic interventions for treating post-TBI depression, it is important to remember that TBI patients have a higher risk of seizures; therefore, the benefits of prescribing medications that lower the seizure threshold need to be weighed against the risk of seizures...
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29707425/psychosis-in-a-child-with-atypical-autism-a-case-report-and-a-brief-review-of-the-association-of-psychosis-and-autism
#11
Swapnajeet Sahoo, Susanta Kumar Padhy, Neha Singla, Aakanksha Singh
Recent studies have shown that individuals with an autism spectrum disorder (ASD) are at an increased risk of developing psychosis. Diagnosing psychosis in such individuals can be challenging when they present with symptoms at a young age. A careful history and thorough assessment are essential for proper diagnosis to avoid mislabeling certain behavioral problems encountered among children with ASD. We present the case of a 12-year-old child with atypical autism who developed psychotic symptoms that led to a diagnostic dilemma...
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29707424/comorbid-insomnia-and-psychiatric-disorders-an-update
#12
REVIEW
Khurshid A Khurshid
Insomnia is a clinical problem of significant public health importance. Insomnia can be a symptom or harbinger of other psychiatric disorders. Insomnia can also be comorbid with other psychiatric disorders, thereby adding to the medical burden and increasing the risk of psychiatric relapse. Insomnia can also be associated with medical and neurological disorders. Some medications can also cause insomnia. Treatment of insomnia can lead to positive outcomes, not only by alleviating symptoms and moderating these comorbid disorders, but by preventing new episodes...
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29707423/effects-of-statins-and-cholesterol-on-patient-aggression-is-there-a-connection
#13
Emily Leppien, Kimberly Mulcahy, Tammie Lee Demler, Eileen Trigoboff, Lewis Opler
Overview : Psychiatric adverse effects, including aggression, have been reported with the use of statin medications; however, there is little data to support or refute the theory that statins or low serum cholesterol do in fact increase a patient's risk of aggression. Objective : This study examined 1) statin use and increased aggression, measured by the requirement of either emergent psychiatric intervention referred to as "Code Green" (CG) or "Restraint and Seclusion" (RS) and 2) cholesterol level and increased aggression in psychiatric inpatients...
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29707422/modafinil-for-the-improvement-of-patient-outcomes-following-traumatic-brain-injury
#14
REVIEW
Amne Borghol, Michael Aucoin, Ifeanyichukwu Onor, Dana Jamero, Fadi Hawawini
Objective : The authors sought to assess the literature evidence on the efficacy of modafinil use in patients with fatigue or excessive daytime sleepiness (EDS) secondary to traumatic brain injury (TBI). Method of Research : A literature search of Medline and PubMed was performed using the EBSCOhost database. Primary literature, observational studies, meta-analyses, case reports, and systematic reviews were assessed for content regarding modafinil and psychostimulant use in patients with TBI. Of the 23 articles collected, three randomized, controlled studies, three observational studies, one case report, and two systematic reviews gave a description of modafinil use in TBI patients...
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29707421/neuroscience-is-the-next-oncology
#15
EDITORIAL
Michael D Ehlers
No abstract text is available yet for this article.
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29707420/prolactin-levels-in-patients-with-schizophrenia-who-were-switched-from-daily-to-once-monthly-aripiprazole-treatment
#16
Masaru Nakamura, Takahiko Nagamine
No abstract text is available yet for this article.
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29707419/olanzapine-and-diabetic-ketoacidosis-what-is-the-underlying-mechanism
#17
Takahiko Nagamine
No abstract text is available yet for this article.
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/29707418/discussing-ant1-role-in-amyotrophic-lateral-sclerosis-pathogenesis
#18
Simona Portaro, Vincenzo Cimino, Antonino Naro, Rocco Salvatore Calabrò
No abstract text is available yet for this article.
April 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/30023138/pneumocephalus-is-the-needle-size-significant
#19
Kolikonda Murali K, Priyanga Jayakumar, Srividya Sriramula, Steven Lippmann
No abstract text is available yet for this article.
February 1, 2018: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/30023137/acute-schizophrenia-like-psychotic-disorder-a-critical-appraisal-of-its-diagnostic-validity-through-a-case-series
#20
Álvaro López-Díaz, Ignacio Lara, José Luis Fernández-González
No abstract text is available yet for this article.
February 1, 2018: Innovations in Clinical Neuroscience
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