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Pediatric Allergy, Immunology, and Pulmonology

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https://www.readbyqxmd.com/read/27583171/feasibility-of-picture-based-asthma-medication-plans-in-urban-pediatric-outpatient-clinics
#1
Stephanie J Mitchell, Andrew L Bilderback, Sande O Okelo
Picture-based Asthma Action Plans show promise for overcoming parental literacy barriers and improving child asthma outcomes, but it is uncertain how parents respond to pictures of specific medications, which may be particularly important for improving disease self-management. Thus, we assessed parent attitudes toward an asthma-related picture-based medication plan (PBMP) in an urban academic pediatric clinic and examined attitudes by literacy level. Surveys were administered to a convenience sample of parents of children presenting to an urban pediatric pulmonary clinic for asthma consultation between March and August 2011...
June 1, 2016: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/27458539/macrolides-for-acute-wheezing-episodes-in-preschool-children
#2
Hengameh H Raissy, Kathryn Blake
The National Asthma Education and Prevention Program's Expert Panel Report 3, Guidelines for the Diagnosis and Management of Asthma does not recommend antibiotics for the management of acute episodes of asthma exacerbation. Macrolides seem to have some potential effect beyond or in addition to their antibacterial effect. It has been reported that macrolides may potentially benefit patients with chronic inflammatory airway diseases due to their antibacterial, antiviral, and/or anti-inflammatory effects. This review presents recent data on use of azithromycin in prevention and management of acute exacerbation of respiratory symptoms in infants and young children...
June 1, 2016: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/27458538/rituximab-desensitization-in-pediatric-patients-results-of-a-case-series
#3
Meredith A Dilley, Joyce P Lee, Craig D Platt, Ana Dioun Broyles
Rituximab is a monoclonal antibody (mAb) primarily used to treat oncologic and autoinflammatory conditions. Although hypersensitivity reactions (HSRs) and desensitization protocols to mAbs have been well described in adults, the experience in the pediatric population is very limited. We sought to determine the safety and efficacy of desensitization to rituximab in the pediatric population at our institution. We retrospectively reviewed the experience with HSRs and desensitization to rituximab during a 5-year period in our tertiary care pediatric center, including reaction evaluation, premedication regimens, and desensitization procedures and protocols...
June 1, 2016: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/27458537/a-proof-of-concept-study-to-detect-urease-producing-bacteria-in-lungs-using-aerosolized-13-c-urea
#4
Hengameh H Raissy, Graham Timmins, Lea Davies, Theresa Heynekamp, Michelle Harkins, Zachary D Sharp, H William Kelly
This is a "proof of concept" study to determine whether inhalation of (13)C-urea can be safely used to detect the presence of urease producing bacteria in the airways of patients with cystic fibrosis (CF) by detecting (13)CO2 in breath. This was a prospective, 2-part, open label, single-center, single-arm, single-administration, dose-escalation investigational device exemption trial. First, the safety of 20 and 50 mg inhaled (13)C-urea was evaluated in 6 healthy adult participants. Then, 3 adult CF participants colonized with Pseudomonas aeruginosa were enrolled for each dose of inhaled (13)C-urea...
June 1, 2016: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/27158551/through-the-looking-glass-chronic-urticaria-treated-with-anti-ige-therapy
#5
Giovanni B Pajno
No abstract text is available yet for this article.
March 1, 2016: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/27158550/do-written-asthma-action-plans-improve-outcomes
#6
John M Kelso
With appropriate management, children with asthma should expect few symptoms, no limits on activity, rare exacerbations, and normal lung function. Appropriate education of parents and other caregivers of children with asthma has clearly been shown to help achieve these goals. Although recommended in asthma guidelines, providing written asthma action plans does not improve outcomes beyond asthma education alone.
March 1, 2016: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/26697265/lung-transplantation-in-cystic-fibrosis-trends-and-controversies
#7
Joshua Blatter, Stuart Sweet
This article is not an overview of all facets of lung transplantation in cystic fibrosis (CF), but rather it is intended as a review of current allocation controversies, as well as of trends in diagnostics and management in lung transplant recipients and in patients with end-stage lung disease. Despite changes in donor and recipient selection, long-term survival in pediatric lung transplant has continued to be limited by chronic lung allograft dysfunction (CLAD). Due to, in part, this short survival benefit, transplant continues to be an appropriate option for only a subset of pediatric patients with CF...
December 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/26421215/adolescent-asthma-pharmacotherapy-in-a-state-of-flux
#8
Hengameh Raissy, Kathryn Blake
Recently, the United States Food and Drug Administration (FDA) elected not to approve a once-daily inhaled corticosteroid/long-acting β2 agonist combination product in 12-17-year-old patients due to lack of sufficient data, despite approval of previous combination products with similar levels of supporting evidence. As the FDA's stance toward adolescent data is changing, the opportunity to learn about their response to asthma medication has now arisen. A review of the relevant issues pertinent to pharmacotherapy of asthma in the 12-17-year-old population is discussed in this review...
September 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/26421214/application-of-an-asthma-screening-questionnaire-in-children-with-sickle-cell-disease
#9
Aravind Yadav, Fernando F Corrales-Medina, James M Stark, S Shahrukh Hashmi, Mary P Carroll, Keely G Smith, Kristen M Meulmester, Deborah L Brown, Cindy Jon, Ricardo A Mosquera
Objective: Asthma in sickle cell disease (SCD) patients is associated with elevated morbidity and mortality. Early detection and initiation of treatment may therefore lead to improved outcome. Utility of an asthma screening questionnaire to identify obstructive airway disease and physician diagnosed asthma in children with SCD at an outpatient setting as an effective, easy-to-administer screening tool has not previously been evaluated in this population. Methods: A previously validated asthma screening questionnaire and spirometry were prospectively administered to 41 SCD children at a routine clinic visit...
September 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/26421213/urine-club-cell-16-kda-secretory-protein-and-childhood-wheezing-illnesses-after-lower-respiratory-tract-infections-in-infancy
#10
Christian Rosas-Salazar, Tebeb Gebretsadik, Kecia N Carroll, Sara Reiss, Nancy Wickersham, Emma K Larkin, Kristina M James, E Kathryn Miller, Larry J Anderson, Tina V Hartert
Background: Infants with lower respiratory tract infections (LRTIs) are at an increased risk of developing childhood wheezing illnesses (including asthma), but it is not currently possible to predict those at risk for these long-term outcomes. The current objective was to examine whether urine levels of club cell 16-kDa secretory protein (CC16) at the time of an infant LRTI are associated with the development of childhood wheezing illnesses. Methods: Prospective study of 133 previously healthy infants enrolled during a healthcare visit for a LRTI and followed longitudinally for childhood wheezing illnesses...
September 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/26155370/development-of-a-tool-to-evaluate-asthma-preparedness-and-management-in-child-care-centers
#11
Chelsea A Young, Curtis Chan, Jodi Stookey, Anisha I Patel, Jane Evans, Karen Cohn, Luz Agana, Irene H Yen, Alicia Fernandez, Michael D Cabana
Introduction: Asthma is a common condition affecting many children in child-care centers. The National Asthma Education and Prevention Program offers recommendations about creating an asthma-friendly child-care setting. However, no studies have investigated the extent to which child-care centers adhere to these recommendations. This study describes the development of a novel instrument to determine the ability of child-care centers to meet national recommendations for asthma. Methods: The Preparing for Asthma in Child Care (PACC) Instrument was developed using information from existing recommendations and standards, the peer-reviewed literature, site visits, and expert interviews...
June 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/26155369/respiratory-severity-score-separates-upper-versus-lower-respiratory-tract-infections-and-predicts-measures-of-disease-severity
#12
Amy S Feldman, Tina V Hartert, Tebeb Gebretsadik, Kecia N Carroll, Patricia A Minton, Kimberly B Woodward, Emma K Larkin, Eva Kathryn Miller, Robert S Valet
Background: A respiratory severity score (RSS) describing acute respiratory illness (ARI) severity would be useful for research and clinical purposes. Methods: A total of 630 term infants presenting with ARI had their RSS measured. Results: RSS was higher in those with lower respiratory tract infection (LRTI) compared with those with upper respiratory infection (URI; LRTI 6.5 [4-8.5]; URI 1 [0-2], p<0.001) and in hospitalized infants compared with outpatients (hospitalized 6.5 [4-9]; outpatient 1 [0-3], p<0...
June 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/26155368/relationship-between-serum-interleukin-17f-level-and-severity-of-atopic-dermatitis-in-children
#13
Young A Park, Yoon Hee Kim, In Suk Sol, Seo Hee Yoon, Jung Yeon Hong, Mi Na Kim, Kyung Eun Lee, Kyung Won Kim, Kyu-Earn Kim, Myung Hyun Sohn
Background: Recent discovery of the Th17 pathway is providing new opportunities for understanding chronic immune-mediated diseases. The Th17 pathway has been historically associated with chronic inflammatory diseases such as psoriasis, multiple sclerosis, and rheumatoid arthritis. Among Th17 cytokines, pathogenic roles of IL-17A and IL-17F in asthma have been well described. Recently, the number of peripheral blood Th17 cells was found to correlate with disease severity in patients with atopic dermatitis (AD)...
June 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/26155367/identification-of-il13-c1923t-as-a-single-nucleotide-polymorphism-for-asthma-in-children-from-mauritius
#14
Kamleshun Ramphul, Li Hua, Yi Xiao Bao, Jing Yang Li, Quan Hua Liu, Ruo Xu Ji, Ding Zhu Fang
Background: Research increasingly suggests that asthma is a familial and hereditary disorder and that genetic and environmental factors play a key role in its pathogenesis. Objective: The aim of this study was to investigate the associations between 10 single nucleotide polymorphism (SNP) loci in the development of asthma in children from the Mauritian population. Methods: The study population consisted of 193 children with asthma and 189 healthy controls from the Mauritian population. Asthma was diagnosed in accordance with the American Thoracic Society criteria...
June 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/26155366/the-clinical-relevance-of-various-hypersensitivity-tests-in-patients-with-atopic-dermatitis-as-assessed-by-their-history-scorad-changes-and-number-of-days-with-need-of-anti-inflammatory-treatment
#15
Martin Liska, Vaclava Gutova, Petr Panzner, Petra Brodska
Immediate and delayed hypersensitivity reactions can play a role in the pathogenesis of atopic dermatitis (AD). We tested 71 patients (median age 5 years) with AD for hypersensitivity to grass and birch pollen, Dermatophagoides pteronyssinus, and Dermatophagoides farinae using atopy patch test (APT), skin prick test (SPT), and specific IgE measurement. The sensitivity (SE) and specificity (SP) of the tests were calculated on the basis of personal history of AD exacerbation, clinical AD score (SCORAD) changes, and the number of days with need for topical anti-inflammatory treatment (AITD) in relation to exposure to the allergens being tested...
June 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/25852969/vitamin-d-and-asthma-association-causality-or-intervention
#16
Hengameh Raissy, Kathryn Blake
Many observational studies have investigated the potential association between vitamin D and asthma. However, it is difficult to find a temporal causal relationship in cross-sectional or observational studies. This review presents recent clinical trials and the evidence of association between vitamin D and asthma in different patient populations and asthma status. Well-designed clinical trials are warranted in order to define the optimal level of vitamin D, as well as dosing and duration of vitamin D supplementation, in pediatric patients...
March 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/25852968/median-household-income-association-with-mortality-in-children-on-chronic-ventilation-at-home-secondary-to-bronchopulmonary-dysplasia
#17
A Ioana Cristea, Veda L Ackerman, Stephanie D Davis, Aaron E Carroll, Stephen M Downs, Zhangsheng Yu, James E Slaven, Nancy L Swigonski
Objective: The aim of this study was to determine if living in a lower income neighborhood is associated with mortality of patients with bronchopulmonary dysplasia (BPD) on home ventilation. Methods: Patients were divided into two groups by their ZIP code-based annual household income (Z-AHI), their year of birth, and the median state household income. Survival, liberation from ventilation, and decannulation rates were analyzed between the groups. Results: Over 27 years, 94 patients met our inclusion criteria: 58 (61...
March 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/25852967/the-impact-of-parent-s-health-literacy-on-pediatric-asthma-outcomes
#18
Kathleen F Harrington, Bin Zhang, Teresa Magruder, William C Bailey, Lynn B Gerald
Background: Health literacy has been associated with health disparities in many disease outcomes, including children's asthma. Parents are responsible for most of children's healthcare. Therefore, parents' health literacy may impact children's health outcomes, including asthma control. This study sought to determine the association between parent health literacy and children's asthma control among a cohort of predominately minority urban children aged between 6 and 12 years. Methods: This cross-sectional study assessed children with asthma and their parents at a single outpatient visit...
March 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/25852966/immunoglobulin-resistance-in-kawasaki-disease
#19
Georgios A Hartas, Syed Shahrukh Hashmi, Chi Pham-Peyton, Emmanouil Tsounias, John T Bricker, Monesha Gupta-Malhotra
Background: The aim of this study was to identify risk factors for immunoglobulin resistance, including clinical symptoms such as arthritis and the pH of intravenous immunoglobulin. Methods: The data of children with Kawasaki disease who had received immunoglobulin were evaluated. Data regarding the brand of immunoglobulin administered were abstracted from the pharmacy records. Results: Eighty consecutive children with Kawasaki disease were evaluated (Mdn age=28 months, 66% male). The prevalence of immunoglobulin resistance was 30%...
March 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/25830075/electronic-cigarettes-vulnerability-of-youth
#20
Dean E Schraufnagel
Electronic cigarettes have become popular and are heavily promoted as a safer cigarette and an aid to quit smoking. Although they may have value in reducing cigarette use among smokers, they are of limited value in smoking cessation and pose many problems, particularly in children. Nicotine is highly addictive and affects virtually all cells in the body. It is particularly harmful to developing brains and other organs. The electronic nicotine delivery systems are largely uncontrolled and safety risks are manifold...
March 1, 2015: Pediatric Allergy, Immunology, and Pulmonology
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