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World Journal of Clinical Oncology

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https://www.readbyqxmd.com/read/28246589/difficult-endoscopic-diagnosis-of-a-pancreatic-plasmacytoma-case-report-and-review-of-literature
#1
Nicolas Williet, Radwan Kassir, Muriel Cuilleron, Olivier Dumas, Leslie Rinaldi, Karine Augeul-Meunier, Michèle Cottier, Xavier Roblin, Jean-Marc Phelip
A 71-year-old man, with history of plasmacytoma in relapse since one year, was hospitalized for a initial presentation of acute pancreatitis and hepatitis. Although there was a heterogeneous infiltration around the pancreas head, the diagnosis of an extramedullary localization of his plasmacytoma was not made until later. This delayed diagnosis was due to the lack of specific radiologic features and the lack of dilatation of biliary ducts at the admission. A diagnosis was made with a simple ultrasound guided paracentesis of the low abundance ascites after a transjugular hepatic biopsy, an endoscopic ultrasound-guided fine needle aspiration of the pancreatic mass, and a failed attempt of biliary drainage through endoscopic retrograde cholangiopancreatography...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28246588/intermittent-facial-spasms-as-the-presenting-sign-of-a-recurrent-pleomorphic-adenoma
#2
Rosalie A Machado, Sami P Moubayed, Azita Khorsandi, Juan C Hernandez-Prera, Mark L Urken
The intimate anatomical relationship of the facial nerve to the parotid parenchyma has a significant influence on the presenting signs and symptoms, diagnosis and treatment of parotid neoplasms. However, to our knowledge, hyperactivity of this nerve, presenting as facial spasm, has never been described as the presenting sign or symptom of a parotid malignancy. We report a case of carcinoma arising in a recurrent pleomorphic adenoma of the left parotid gland (i.e., carcinoma ex pleomorphic adenoma) that presented with hemifacial spasms...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28246587/salient-concerns-in-using-analgesia-for-cancer-pain-among-outpatients-a-cluster-analysis-study
#3
Salimah H Meghani, George J Knafl
AIM: To identify unique clusters of patients based on their concerns in using analgesia for cancer pain and predictors of the cluster membership. METHODS: This was a 3-mo prospective observational study (n = 207). Patients were included if they were adults (≥ 18 years), diagnosed with solid tumors or multiple myelomas, and had at least one prescription of around-the-clock pain medication for cancer or cancer-treatment-related pain. Patients were recruited from two outpatient medical oncology clinics within a large health system in Philadelphia...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28246586/ndrg2-gene-copy-number-is-not-altered-in-colorectal-carcinoma
#4
Anders Lorentzen, Cathy Mitchelmore
AIM: To investigate if the down-regulation of N-myc Downstream Regulated Gene 2 (NDRG2) expression in colorectal carcinoma (CRC) is due to loss of the NDRG2 allele(s). METHODS: The following were investigated in the human colorectal cancer cell lines DLD-1, LoVo and SW-480: NDRG2 mRNA expression levels using quantitative reverse transcription-polymerase chain reaction (qRT-PCR); interaction of the MYC gene-regulatory protein with the NDRG2 promoter using chromatin immunoprecipitation; and NDRG2 promoter methylation using bisulfite sequencing...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28246585/nanoparticle-linked-antagonist-for-leptin-signaling-inhibition-in-breast-cancer
#5
Tia Harmon, Adriana Harbuzariu, Viola Lanier, Crystal C Lipsey, Ward Kirlin, Lily Yang, Ruben R Gonzalez-Perez
AIM: To develop a leptin peptide receptor antagonist linked to nanoparticles and determine its effect on viability of breast cancer cells. METHODS: The leptin antagonist, LPrA2, was coupled via EDAC [1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide] to iron oxide nanoparticles (IONP-LPrA2) to increase its efficacy. IONP-LPrA2 conjugation was confirmed by Western blot and nanoparticle tracking analysis. Human triple negative breast cancer (TNBC) MDA-MB-231, HCC1806 and estrogen receptor positive (ER(+)) MCF-7 cells were analyzed for the expression of the leptin receptor, Ob-R...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28246584/from-targeting-the-tumor-to-targeting-the-immune-system-transversal-challenges-in-oncology-with-the-inhibition-of-the-pd-1-pd-l1-axis
#6
REVIEW
Melissa Bersanelli, Sebastiano Buti
After that the era of chemotherapy in the treatment of solid tumors have been overcome by the "translational era", with the innovation introduced by targeted therapies, medical oncology is currently looking at the dawn of a new "immunotherapy era" with the advent of immune checkpoint inhibitors (CKI) antibodies. The onset of PD-1/PD-L1 targeted therapy has demonstrated the importance of this axis in the immune escape across almost all human cancers. The new CKI allowed to significantly prolong survival and to generate durable response, demonstrating remarkable efficacy in a wide range of cancer types...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28246583/three-dimensional-bio-printing-a-new-frontier-in-oncology-research
#7
REVIEW
Nitin Charbe, Paul A McCarron, Murtaza M Tambuwala
Current research in oncology deploys methods that rely principally on two-dimensional (2D) mono-cell cultures and animal models. Although these methodologies have led to significant advancement in the development of novel experimental therapeutic agents with promising anticancer activity in the laboratory, clinicians still struggle to manage cancer in the clinical setting. The disappointing translational success is attributable mainly to poor representation and recreation of the cancer microenvironment present in human neoplasia...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28246582/therapeutic-management-options-for-stage-iii-non-small-cell-lung-cancer
#8
REVIEW
Stephanie M Yoon, Talha Shaikh, Mark Hallman
Lung cancer is the leading cause of cancer death worldwide. Majority of newly diagnosed lung cancers are non-small cell lung cancer (NSCLC), of which up to half are considered locally advanced at the time of diagnosis. Patients with locally advanced stage III NSCLC consists of a heterogeneous population, making management for these patients complex. Surgery has long been the preferred local treatment for patients with resectable disease. For select patients, multi-modality therapy involving systemic and radiation therapies in addition to surgery improves treatment outcomes compared to surgery alone...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28008384/circulating-cytokeratin-positive-cells-and-tumor-budding-in-colorectal-cancer
#9
Bruno Märkl, Narjes Wilhelms, Matthias Anthuber, Gerhard Schenkirsch, Günter Schlimok, Daniel Oruzio
AIM: To investigate whether circulating cytokeratin-positive (CK(+)) cells in the mesenteric blood of resected colorectal specimens are prognostic and correlate with tumor budding. METHODS: Fifty-six colorectal specimens were collected between 9/2007 and 7/2008. Blood from the mesenteric vein was drawn immediately after receiving the fresh and unfixed specimens in the pathology department. After separation of the mononuclear cells by Ficoll-Hypaque density-gradient centrifugation, cytological smears were immunocytochemically stained for CK18...
December 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28008383/better-to-be-alone-than-in-bad-company-the-antagonistic-effect-of-cisplatin-and-crizotinib-combination-therapy-in-non-small-cell-lung-cancer
#10
Nele Van Der Steen, Christophe Deben, Vanessa Deschoolmeester, An Wouters, Filip Lardon, Christian Rolfo, Paul Germonpré, Elisa Giovannetti, Godefridus J Peters, Patrick Pauwels
AIM: To investigate the potential benefit of combining the cMET inhibitor crizotinib and cisplatin we performed in vitro combination studies. METHODS: We tested three different treatment schemes in four non-small cell lung cancer (NSCLC) cell lines with a different cMET/epidermal growth factor receptor genetic background by means of the sulforhodamine B assay and performed analysis with Calcusyn. RESULTS: All treatment schemes showed an antagonistic effect in all cell lines, independent of the cMET status...
December 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777885/male-papillary-breast-cancer-treated-by-wide-resection-and-latissimus-dorsi-flap-reconstruction-a-case-report-and-review-of-the-literature
#11
Malgorzata Banys-Paluchowski, Eike Burandt, Joanna Banys, Stefan Geist, Guido Sauter, Natalia Krawczyk, Peter Paluchowski
Breast cancer (BC) in men represents between 0.5% and 1% of all BC diagnosed each year. We report a case of advanced BC in a 62-year-old male treated at our interdisciplinary Breast Cancer Center. The patient presented with a newly diagnosed large, symptomatic mass in his left breast. Clinical examination showed a not movable mass of 16 cm diameter, deforming the whole breast; the overlying skin was livid and hypervascularized. Enlarged lymph nodes were palpable in the axillary pit. He had no concomitant diseases at time of presentation...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777884/bone-and-soft-tissue-tumors-presenting-as-sciatic-notch-dumbbell-masses-a-critical-differential-diagnosis-of-sciatica
#12
Yoshihiro Matsumoto, Tomoya Matsunobu, Katsumi Harimaya, Kenichi Kawaguchi, Mitsumasa Hayashida, Seiji Okada, Toshio Doi, Yukihide Iwamoto
AIM: To study the clinical findings and characteristic features in sciatic notch dumbbell tumors (SNDTs). METHODS: We retrospectively reviewed the clinical outcomes and characteristic features of consecutive cases of SNDTs (n = 8). RESULTS: Buttock masses occurred in three patients with SNDT (37.5%). Severe buttock tenderness and pain at rest were observed in seven patients with SNDTs (87.5%). Remarkably, none of the patients with SNDTs experienced back pain...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777883/factors-associated-with-cervical-cancer-screening-in-a-safety-net-population
#13
Meredith A Heberer, Ian K Komenaka, Jesse N Nodora, Chiu-Hsieh Hsu, Sonal G Gandhi, Lauren E Welch, Marcia E Bouton, Paula Aristizabal, Barry D Weiss, Maria Elena Martinez
AIM: To identify factors associated with Papanicolaou-smear (Pap-smear) cervical cancer screening rates in a safety net population. METHODS: From January 2012 to May 2013, the use of Pap-smear was determined for all patients seen at the breast clinic in a safety net hospital. Health literacy assessment was performed using the validated Newest Vital Sign. The records of patients were reviewed to determine if they had undergone Pap-smears for cervical cancer screening...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777882/cigarette-smoking-dietary-habits-and-genetic-polymorphisms-in-gstt1-gstm1-and-cyp1a1-metabolic-genes-a-case-control-study-in-oncohematological-diseases
#14
María Belén Cerliani, Walter Pavicic, Juan Antonio Gili, Graciela Klein, Silvia Saba, Silvina Richard
AIM: To analyze the association between oncohematological diseases and GSTT1/GSTM1/CYP1A1 polymorphisms, dietary habits and smoking, in an argentine hospital-based case-control study. METHODS: This hospital-based case-control study involved 125 patients with oncohematological diseases and 310 control subjects. A questionnaire was used to obtain sociodemographic data and information about habits. Blood samples were collected, and DNA was extracted using salting out methods...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777881/tumor-infiltrating-lymphocytes-in-triple-negative-breast-cancer-receiving-neoadjuvant-chemotherapy
#15
Carlos A Castaneda, Elizabeth Mittendorf, Sandro Casavilca, Yun Wu, Miluska Castillo, Patricia Arboleda, Teresa Nunez, Henry Guerra, Carlos Barrionuevo, Ketty Dolores-Cerna, Carolina Belmar-Lopez, Julio Abugattas, Gabriela Calderon, Miguel De La Cruz, Manuel Cotrina, Jorge Dunstan, Henry L Gomez, Tatiana Vidaurre
AIM: To determine influence of neoadjuvant-chemotherapy (NAC) over tumor-infiltrating-lymphocytes (TIL) in triple-negative-breast-cancer (TNBC). METHODS: TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays (TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777880/granulocyte-colony-stimulating-factor-producing-hepatocellular-carcinoma-with-abrupt-changes
#16
REVIEW
Hiroaki Nagata, Shuhei Komatsu, Wataru Takaki, Tokunari Okayama, Yasunori Sawabe, Michiaki Ishii, Mitsuo Kishimoto, Eigo Otsuji, Hiroshi Konosu
Granulocyte colony-stimulating factor (G-CSF)-producing tumor is one of the rare types of cancer clinically characterized by an elevated fever and white blood cell (WBC) increment. Although G-CSF producing tumors have been reported in several types of cancer including those of the lungs, cervix and bladder, G-CSF producing hepatocellular carcinoma is extremely rare. Here, we report the case of a rapidly growing and poorly differentiated hepatocellular carcinoma producing G-CSF. The patient showed symptoms of continuous high fever, stomach pain and cough, and high serum WBC counts, C-reactive protein (CRP) and G-CSF levels were found in laboratory tests...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777879/accelerated-partial-breast-irradiation-past-present-and-future
#17
REVIEW
Anne W Tann, Sandra S Hatch, Melissa M Joyner, Lee R Wiederhold, Todd A Swanson
Accelerated partial breast irradiation (APBI) focuses higher doses of radiation during a shorter interval to the lumpectomy cavity, in the setting of breast conserving therapy for early stage breast cancer. The utilization of APBI has increased in the past decade because of the shorter treatment schedule and a growing body of outcome data showing positive cosmetic outcomes and high local control rates in selected patients undergoing breast conserving therapy. Technological advances in various APBI modalities, including intracavitary and interstitial brachytherapy, intraoperative radiation therapy, and external beam radiation therapy, have made APBI more accessible in the community...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777878/role-of-akt-signaling-in-resistance-to-dna-targeted-therapy
#18
REVIEW
Abolfazl Avan, Ravi Narayan, Elisa Giovannetti, Godefridus J Peters
The Akt signal transduction pathway controls most hallmarks of cancer. Activation of the Akt cascade promotes a malignant phenotype and is also widely implicated in drug resistance. Therefore, the modulation of Akt activity is regarded as an attractive strategy to enhance the efficacy of cancer therapy and irradiation. This pathway consists of phosphatidylinositol 3 kinase (PI3K), mammalian target of rapamycin, and the transforming serine-threonine kinase Akt protein isoforms, also known as protein kinase B...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777877/oncogenic-fingerprint-of-epidermal-growth-factor-receptor-pathway-and-emerging-epidermal-growth-factor-receptor-blockade-resistance-in-colorectal-cancer
#19
REVIEW
Zain A Sobani, Ashwin Sawant, Mikram Jafri, Amit Keith Correa, Ibrahim Halil Sahin
Epidermal growth factor receptor (EGFR) has been an attractive target for treatment of epithelial cancers, including colorectal cancer (CRC). Evidence from clinical trials indicates that cetuximab and panitumumab (anti-EGFR monoclonal antibodies) have clinical activity in patients with metastatic CRC. The discovery of intrinsic EGFR blockade resistance in Kirsten RAS (KRAS)-mutant patients led to the restriction of anti-EGFR antibodies to KRAS wild-type patients by Food and Drug Administration and European Medicine Agency...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27777876/transanal-total-mesorectal-excision-myths-and-reality
#20
EDITORIAL
Nicolas C Buchs, Marta Penna, Alexander L Bloemendaal, Roel Hompes
Transanal total mesorectal excision (TaTME) is a new and promising approach for the treatment of rectal cancer. Whilst the experience is still limited, there are growing evidences that this approach might overcome the limits of standard low anterior resection. TaTME might help to decrease the conversion rate especially in difficult patients, and to improve the pathological results, while preserving the urogenital function. Evaluation of data from large registries and randomized studies should help to draw firmer conclusions...
October 10, 2016: World Journal of Clinical Oncology
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