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Therapeutic Advances in Drug Safety

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https://www.readbyqxmd.com/read/29854393/impact-of-dextrose-dose-on-hypoglycemia-development-following-treatment-of-hyperkalemia
#1
Nicholas Farina, Christopher Anderson
Background: Hyperkalemia is an electrolyte abnormality that may cause ventricular dysrhythmias and cardiac arrest. The presence of hyperkalemia may necessitate prompt treatment via intravenous insulin and dextrose. One notable complication of this therapy is the development of hypoglycemia. Previous trials have examined the impact of altering the insulin dose administered on hypoglycemia development; no trials to date however, have examined the impact of altering the dextrose dose. Methods: This was a multicenter, retrospective, matched cohort study of patients who received intravenous insulin and dextrose for reversal of hyperkalemia...
June 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29854392/the-willingness-and-attitude-of-patients-towards-self-administration-of-medication-in-hospital
#2
Toke Vanwesemael, Koen Boussery, Patricia van den Bemt, Tinne Dilles
Background: Literature suggests a positive impact of self-administration of medication during hospitalization on medication adherence and safety, and on patient satisfaction. However, self-administration is not a common practice in Belgian hospitals. The aim of this study was to describe patients' willingness towards self-administration of medication while in hospital. Methods: A cross-sectional observational study was conducted in three Belgian hospitals in November and December 2015...
June 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29854391/evaluating-the-risk-of-qtc-prolongation-associated-with-antidepressant-use-in-older-adults-a-review-of-the-evidence
#3
REVIEW
Matthew P Rochester, Allison M Kane, Sunny Anne Linnebur, Danielle R Fixen
Antidepressants are widely used medications for a range of medical conditions such as mood disorders and chronic pain in older adults. A vast body of evidence exists concerning the risks of QT interval prolongation associated with these agents and healthcare providers should critically evaluate the potential for QT prolongation when selecting antidepressant agents. Long QT syndrome is a disorder of myocardial repolarization that manifests as a prolonged QT interval on an electrocardiogram (ECG) and has been demonstrated to increase with age...
June 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29854390/metformin-treatment-of-type-2-diabetes-mellitus-in-pregnancy-update-on-safety-and-efficacy
#4
REVIEW
Thomas M Polasek, Matthew P Doogue, Tilenka R J Thynne
With the increasing prevalence of type 2 diabetes mellitus (T2DM) in women of childbearing age, prescribing antidiabetic medications in first-trimester pregnancy is becoming more common. Metformin treatment during this time is usually avoided in countries with well-resourced healthcare. This is based on historical concerns about safety to the foetus and the widespread availability of insulin. However, there is now increasing interest in the potential benefits of metformin in pregnant women with T2DM. In this commentary, the main evidence supporting metformin safety in pregnancy is summarized, with an emphasis on the first trimester...
June 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29854389/eltrombopag-in-immune-thrombocytopenia-efficacy-review-and-update-on-drug-safety
#5
REVIEW
Jose Ramon Gonzalez-Porras, Jose Maria Bastida
Immune thrombocytopenia (ITP) is an autoimmune disorder that induces a decrease in the number of circulating platelets due to spleen destruction and inability of megakaryocytes to restore normal counts. Immunosuppressive therapy with glucocorticoid drugs constitutes the first line of treatment. However, lack of response to these agents is not uncommon, and the management of refractory patients is a matter of controversy. In fact, day-to-day clinical practice shows that, in spite of the current guidelines, splenectomy, which is currently considered a suitable second-choice therapy, is being replaced by treatment with thrombopoietin receptor agonists...
June 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29854388/the-pale-evidence-for-treatment-of-iron-deficiency-anaemia-in-older-people
#6
EDITORIAL
Roy L Soiza, Alison I C Donaldson, Phyo Kyaw Myint
No abstract text is available yet for this article.
June 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29796249/designing-a-novel-antacid-for-sensitive-populations
#7
Amir Sharifi-Sistani, Ali Tafazoli
No abstract text is available yet for this article.
May 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29796248/safety-of-antipsychotics-for-the-treatment-of-schizophrenia-a-focus-on-the-adverse-effects-of-clozapine
#8
REVIEW
Domenico De Berardis, Gabriella Rapini, Luigi Olivieri, Domenico Di Nicola, Carmine Tomasetti, Alessandro Valchera, Michele Fornaro, Fabio Di Fabio, Giampaolo Perna, Marco Di Nicola, Gianluca Serafini, Alessandro Carano, Maurizio Pompili, Federica Vellante, Laura Orsolini, Giovanni Martinotti, Massimo Di Giannantonio
Clozapine, a dibenzodiazepine developed in 1961, is a multireceptorial atypical antipsychotic approved for the treatment of resistant schizophrenia. Since its introduction, it has remained the drug of choice in treatment-resistant schizophrenia, despite a wide range of adverse effects, as it is a very effective drug in everyday clinical practice. However, clozapine is not considered as a top-of-the-line treatment because it may often be difficult for some patients to tolerate as some adverse effects can be particularly bothersome (i...
May 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29796247/managing-acute-pain-in-patients-who-report-lactose-intolerance-the-safety-of-an-old-excipient-re-examined
#9
REVIEW
Deanna Mill, Jessica Dawson, Jacinta Lee Johnson
Lactose intolerance is exceedingly common, reportedly affecting up to 70% of the world's population, leading to both abdominal and systemic symptoms. Current treatment focuses predominantly on restricting dietary consumption of lactose. Given lactose is one of the most commonly used excipients in the pharmaceutical industry, consideration must be given to the lactose content and therefore safety of pharmaceutical preparations prescribed for patients with lactose intolerance. This article summarizes the current literature examining the likelihood of inducing adverse effects through the administration of lactose-containing pharmaceutical preparations in patients reporting lactose intolerance, describes how to assess this risk on an individual patient basis and reviews suitable analgesic options for this population...
May 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29623187/moxifloxacin-induced-tinnitus-in-an-older-adult
#10
Amber Onoh, Sunny A Linnebur, Danielle R Fixen
An increased risk of bacterial resistance toward fluoroquinolones and the increased risk of disabling and serious adverse effects prompted the US Food and Drug Administration to recommend limiting fluoroquinolone use to the treatment of community-acquired pneumonia, skin and skin-structure infections, bacterial sinusitis, plague, chronic bronchitis exacerbations, and complicated intra-abdominal infections. We report a case of moxifloxacin-induced tinnitus in an older adult prescribed oral moxifloxacin 400 mg for 5 days for the treatment of acute diverticulitis, due to allergies to nonfluoroquinolone preferred agents...
April 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29623186/trigger-alerts-associated-with-laboratory-abnormalities-on-identifying-potentially-preventable-adverse-drug-events-in-the-intensive-care-unit-and-general-ward
#11
Mitchell S Buckley, Jeffrey R Rasmussen, Dale S Bikin, Emily C Richards, Andrew J Berry, Mark A Culver, Ryan M Rivosecchi, Sandra L Kane-Gill
Background: Medication safety strategies involving trigger alerts have demonstrated potential in identifying drug-related hazardous conditions (DRHCs) and preventing adverse drug events in hospitalized patients. However, trigger alert effectiveness between intensive care unit (ICU) and general ward patients remains unknown. The objective was to investigate trigger alert performance in accurately identifying DRHCs associated with laboratory abnormalities in ICU and non-ICU settings. Methods: This retrospective, observational study was conducted at a university hospital over a 1-year period involving 20 unique trigger alerts aimed at identifying possible drug-induced laboratory abnormalities...
April 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29623185/spontaneously-reported-adverse-drug-events-related-to-tapentadol-and-oxycodone-naloxone-in-australia
#12
Carmen Abeyaratne, Samanta Lalic, J Simon Bell, Jenni Ilomäki
Background: The rapid increase in prescribing and use of opioids for noncancer pain has coincided with an increase in opioid-related adverse drug events (ADEs). The objective of our study was to describe ADEs related to tapentadol and oxycodone/naloxone spontaneously reported to the Australian Therapeutic Goods Administration (TGA). Methods: Public case detail reports for tapentadol (September 2013-March 2017) and oxycodone/naloxone (April 2011-March 2017) were sourced from the TGA...
April 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29492247/likelihood-of-reporting-medication-errors-in-hospitalized-children-a-survey-of-nurses-and-physicians
#13
Rikke Mie Rishoej, Jesper Hallas, Lene Juel Kjeldsen, Henrik Thybo Christesen, Anna Birna Almarsdóttir
Background: Hospitalized children are at risk of medication errors (MEs) due to complex dosage calculations and preparations. Incident reporting systems may facilitate prevention of MEs but underreporting potentially undermines this system. We aimed to examine whether scenarios involving medications should be reported to a national mandatory incident reporting system and the likelihood of self- and peer-reporting these scenarios among paediatric nurses and physicians. Methods: Participants' reporting of MEs was explored through a questionnaire involving 20 medication scenarios...
March 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29492246/an-update-on-the-safety-of-current-therapies-for-alzheimer-s-disease-focus-on-rivastigmine
#14
REVIEW
Rita Khoury, Jayashree Rajamanickam, George T Grossberg
Alzheimer's disease (AD) is the most common cause of major neurocognitive disorders worldwide. Despite all research efforts, therapeutic options for AD are still limited to two drug classes: cholinesterase inhibitors (ChEIs) and the NMDA-receptor antagonist memantine. Donepezil, rivastigmine and galantamine are the three ChEIs FDA-approved as first-line treatment for AD. Although they share the same mode of action, they differ in terms of their pharmacologic characteristics and route of administration, which can impact their safety and tolerability profile...
March 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29492245/can-supporting-health-literacy-reduce-medication-related-harm-in-older-adults
#15
EDITORIAL
Nikesh Parekh, Khalid Ali, Kevin Davies, Chakravarthi Rajkumar
No abstract text is available yet for this article.
March 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29387338/polypills-for-the-secondary-prevention-of-cardiovascular-disease-effective-in-improving-adherence-but-are-they-safe
#16
REVIEW
Vanessa Selak, Ruth Webster
International guidelines recommend blood pressure-lowering therapy, statins and aspirin for people who have had a cardiovascular event but use of these medications is low, particularly for lower income countries. Clinical trials have demonstrated that combining these medications into a single pill or capsule (a 'polypill') improves adherence, systolic blood pressure and low density lipoprotein cholesterol compared with usual care in secondary prevention. Uptake of polypill-based care has been underwhelming, possibly due to safety concerns...
February 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29387337/interventions-to-reduce-medication-errors-in-neonatal-care-a-systematic-review
#17
REVIEW
Minh-Nha Rhylie Nguyen, Cassandra Mosel, Luke E Grzeskowiak
Background: Medication errors represent a significant but often preventable cause of morbidity and mortality in neonates. The objective of this systematic review was to determine the effectiveness of interventions to reduce neonatal medication errors. Methods: A systematic review was undertaken of all comparative and noncomparative studies published in any language, identified from searches of PubMed and EMBASE and reference-list checking. Eligible studies were those investigating the impact of any medication safety interventions aimed at reducing medication errors in neonates in the hospital setting...
February 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29387336/influence-of-stroke-and-bleeding-risk-on-prescribing-of-oral-anticoagulants-in-older-inpatients-has-the-availability-of-direct-oral-anticoagulants-changed-prescribing
#18
Nicholas Farinola, Gillian E Caughey, J Simon Bell, Sally Johns, Milka Hauta-Aho, Sepehr Shakib
Background: Little is known about changes in prescribing practices in Australia since the introduction of the direct oral anticoagulants (DOACs). Our objective was to examine if the availability of DOACs has coincided with a change in prescribing of oral anticoagulants in older hospital inpatients with regard to risk factors for stroke and bleeding. Methods: A prospective observational study was conducted between October 2012 and August 2015 of inpatients aged over 60 years initiated on an oral anticoagulant in a large metropolitan, tertiary referral, public teaching hospital in Australia...
February 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29387335/contemporary-utilization-of-antithrombotic-therapy-for-stroke-prevention-in-patients-with-atrial-fibrillation-an-audit-in-an-australian-hospital-setting
#19
Ekta Yogeshkumar Pandya, Elizabeth Anderson, Clara Chow, Yishen Wang, Beata Bajorek
Background: To document antithrombotic utilization in patients with nonvalvular atrial fibrillation (NVAF), particularly, recently approved NOACs (nonvitamin K antagonist oral anticoagulants) and warfarin; and identify factors predicting the use of NOACs versus warfarin. Methods: A retrospective audit was conducted in an Australian hospital. Data pertaining to inpatients diagnosed with atrial fibrillation (AF) admitted between January and December 2014 were extracted...
February 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29318007/severe-haematuria-of-lower-urinary-tract-origin-with-low-dose-dabigatran-use-in-three-indian-elderly-patients-unresolved-issues-in-the-safety-of-novel-oral-anticoagulants
#20
Upinder Kaur, Sankha Shubhra Chakrabarti, Sukdev Manna, Indrajeet Singh Gambhir
Dabigatran is a newer oral direct thrombin inhibitor approved by the United States Food and Drug Administration and the European Medicines Agency (EMA). The proper dosage of the drug, the potential for adverse drug reactions and the nature of bleeds with use of this drug as with other novel oral anticoagulants (NOACs), in the elderly population are still areas of uncertainty. Despite the existence of a specific antibody, idarucizumab which is an antidote to dabigatran toxicity, management of dabigatran-induced bleeds is an undefined area especially in resource constrained settings...
January 2018: Therapeutic Advances in Drug Safety
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