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Therapeutic Advances in Drug Safety

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https://www.readbyqxmd.com/read/29090085/assessing-and-predicting-drug-induced-anticholinergic-risks-an-integrated-computational-approach
#1
Dong Xu, Heather D Anderson, Aoxiang Tao, Katia L Hannah, Sunny A Linnebur, Robert J Valuck, Vaughn L Culbertson
BACKGROUND: Anticholinergic (AC) adverse drug events (ADEs) are caused by inhibition of muscarinic receptors as a result of designated or off-target drug-receptor interactions. In practice, AC toxicity is assessed primarily based on clinician experience. The goal of this study was to evaluate a novel concept of integrating big pharmacological and healthcare data to assess clinical AC toxicity risks. METHODS: AC toxicity scores (ATSs) were computed using drug-receptor inhibitions identified through pharmacological data screening...
November 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29090084/non-medical-prescribing-in-new-zealand-an-overview-of-prescribing-rights-service-delivery-models-and-training
#2
REVIEW
Rakhee Raghunandan, June Tordoff, Alesha Smith
AIM: In this paper, we aim to provide an updated source of information for nonmedical prescribing (NMP) in New Zealand (NZ). METHODS: A variety of NZ sources were used to collect data: legislation, policy documents and information from professional and regulatory organizations, and education providers. RESULTS: In NZ, the legal categories for prescribers include authorized, designated, and delegated prescribers. Authorized prescribers include dentists, midwives, nurse practitioners, and optometrist prescribers...
November 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29090083/gastrointestinal-adverse-effects-of-cyclin-dependent-kinase-4-and-6-inhibitors-in-breast-cancer-patients-a-systematic-review-and-meta-analysis
#3
REVIEW
Kyrillus S Shohdy, Shaimaa Lasheen, Loay Kassem, Omar Abdel-Rahman
BACKGROUND: Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors show promising results in metastatic breast cancer. However, an increased incidence of adverse events is remarkable. Among others, gastrointestinal (GI) involvement is of momentous impact on patients and their quality of life. METHODS: Our search included PubMed, ASCO, ESMO and SABCS databases. Randomized phase II/III trials in metastatic breast cancer receiving CDK4/6 inhibitors were identified and considered relevant based on providing a sufficient safety profile on the incidence of adverse GI effects...
November 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28861212/revised-disproportionality-analysis-of-mirena-and-benign-intracranial-hypertension
#4
Mahyar Etminan
No abstract text is available yet for this article.
September 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28861211/adverse-effects-of-proton-pump-inhibitor-use-in-older-adults-a-review-of-the-evidence
#5
REVIEW
Marina L Maes, Danielle R Fixen, Sunny Anne Linnebur
Proton-pump inhibitors (PPIs) are a widely prescribed class of medications used to treat acid-related disorders and use has significantly increased over the last few decades. PPIs are often inappropriately prescribed and since they have been on the market, a number of post-marketing studies have been published demonstrating associations between longer duration of PPI therapy and a number of adverse effects that are a concern in older adults. The objective of this review is to discuss the existing literature of potential adverse effects with long-term PPI use in older adults and to summarize the implications in clinical practice...
September 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28861210/pharmacogenetics-and-precision-medicine-is-inflammation-a-covert-threat-to-effective-genotype-based-therapy
#6
EDITORIAL
Rashmi R Shah
No abstract text is available yet for this article.
September 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28781738/digital-necrosis-a-potential-risk-of-high-dose-norepinephrine
#7
Rafael Daroca-Pérez, Miguel F Carrascosa
No abstract text is available yet for this article.
August 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28781737/multidrug-intolerance-in-the-treatment-of-hypertension-result-from-an-audit-of-a-specialized-hypertension-service
#8
Basil N Okeahialam
BACKGROUND: Hypertension as a cardiovascular disease risk factor continues to take a heavy toll on the population despite efforts with containment. Poor control, even among those on treatment, is part of the challenge and results from patient, physician and health system factors. When the problem resides at patient level, adherence is largely responsible. An entity defined as multidrug intolerance (MDI) is hardly considered. A situation when a patient is willing to adhere but is compelled otherwise could frustrate both patient and physician...
August 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28845232/solifenacin-linked-qt-interval-prolongation-and-torsades-de-pointes
#9
Jonathan J H Bray, Jules C Hancox
No abstract text is available yet for this article.
July 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28845231/a-mathematical-framework-to-quantify-the-masking-effect-associated-with-the-confidence-intervals-of-measures-of-disproportionality
#10
François Maignen, Manfred Hauben, Jean-Michel Dogné
BACKGROUND: The lower bound of the 95% confidence interval of measures of disproportionality (Lower95CI) is widely used in signal detection. Masking is a statistical issue by which true signals of disproportionate reporting are hidden by the presence of other medicines. The primary objective of our study is to develop and validate a mathematical framework for assessing the masking effect of Lower95CI. METHODS: We have developed our new algorithm based on the masking ratio (MR) developed for the measures of disproportionality...
July 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28845230/screening-for-valve-disease-in-patients-with-hyperprolactinaemia-disorders-prescribed-cabergoline-a-service-evaluation-and-literature-review
#11
REVIEW
David Gamble, Rachel Fairley, Roderick Harvey, Colin Farman, Nathan Cantley, Stephen J Leslie
OBJECTIVES: The indication for screening for valvular heart disease in patients taking cabergoline is based on evidence from patients with Parkinson's disease on high-dose medication. However, current patients take much lower doses for indications such as hyperprolactinaemia disorders. Contemporary guidelines for echocardiogram monitoring in patients taking cabergoline are conflicting. This study aimed to review current clinical practice in our area regarding echocardiographic screening and to review the literature examining the evidence of valvular heart disease in patients taking lower dose cabergoline...
July 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28607669/risk-factors-for-adverse-drug-reactions-in-pediatric-inpatients-a-systematic-review
#12
REVIEW
Paulo Henrique Santos Andrade, Adriano da Silva Santos, Carlos Adriano Santos Souza, Iza Maria Fraga Lobo, Wellington Barros da Silva
BACKGROUND: The main objective of the present systematic review is to identify potential risk factors for adverse drug reactions (ADRs) through prospective cohort studies in pediatric inpatients. METHODS: The data search was done in the following electronic databases PubMed/MEDLINE; Scopus; LILACS and Web of Science from the earliest record until 31 May 2015. Two reviewers independently screened each study and one of them assessed the methodological quality according to the Newcastle-Ottawa scale for cohort studies...
June 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28607668/future-perspectives-on-nonmedical-prescribing
#13
REVIEW
Derek Stewart, Tesnime Jebara, Scott Cunningham, Ahmed Awaisu, Abdulrouf Pallivalapila, Katie MacLure
Many countries have implemented nonmedical prescribing (NMP) and many others are scoping prescribing practices with a view to developing NMP. This paper provides a future perspective on NMP in light of findings of an umbrella review of aspects of NMP. This is followed by coverage of the Scottish Government strategy of pharmacist prescribing and finally, consideration of two key challenges. The review identified seven systematic reviews of influences on prescribing decision-making, processes of prescribing, and barriers and facilitators to implementation...
June 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28607667/cardiovascular-and-cerebrovascular-risk-with-nonsteroidal-anti-inflammatory-drugs-and-cyclooxygenase-2-inhibitors-latest-evidence-and-clinical-implications
#14
REVIEW
Andrea Fanelli, Daniela Ghisi, Pierangelo Lora Aprile, Francesco Lapi
Observational studies and meta-analyses have shown that the administration of nonsteroidal anti-inflammatory drugs (NSAIDs), especially when prescribed at high doses for long periods of time, can potentially increase the risk of cardiovascular diseases. The increased thrombotic risk related to the use of NSAIDs is mainly due to their cyclooxygenase 2 selectivity. The dosage use, the formulation selected and the duration of the therapy are other factors that can significantly impact on the cardiovascular risk...
June 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28588762/baclofen-overdose-mimicking-anoxic-encephalopathy-a-case-report-and-review-of-the-literature
#15
John J Miller
A patient who has overdosed on baclofen can present with significant neurological symptoms suggestive of a serious brain insult, but with appropriate diagnosis and treatment they often fully recover within 72 h. If the patient had been maintained on chronic baclofen therapy prior to the overdose, one must be watchful for signs of baclofen withdrawal as recovery from the overdose occurs.
May 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28588761/apixaban-concomitant-medicines-and-spontaneous-reports-of-haemorrhagic-events
#16
Gillian E Caughey, Lisa M Kalisch Ellett, John D Barratt, Sepehr Shakib
INTRODUCTION: Little is known about the potential safety issues associated with apixaban in clinical practice and their reporting in spontaneous adverse event (SAE) databases. OBJECTIVE: To describe SAE reports associated with the oral anticoagulant apixaban from Australia, Canada and USA and to examine associated concomitant medicine use. METHODS: SAE report databases from Australia, Canada and the USA were examined for all reports of adverse events associated with apixaban and concomitant medicines from 1 January 2012 to 30 September 2014...
May 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28588760/the-impact-of-database-restriction-on-pharmacovigilance-signal-detection-of-selected-cancer-therapies
#17
Manfred Hauben, Eric Hung, Jennifer Wood, Amit Soitkar, Daniel Reshef
BACKGROUND: The aim of this study was to investigate whether database restriction can improve oncology drug pharmacovigilance signal detection performance. METHODS: We used spontaneous adverse event (AE) reports in the United States (US) Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database. Positive control (PC) drug medical concept (DMC) pairs were selected from safety information not included in the product's first label but subsequently added as label changes...
May 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28439400/proton-pump-inhibitors-and-risk-of-readmission-and-mortality-in-older-patients-discharged-from-a-tertiary-hospital-to-residential-aged-care-facilities
#18
Matthew A Pegoli, Maneesha Dedigama, Arduino A Mangoni, Patrick T Russell, Luke E Grzeskowiak, Tilenka Thynne
No abstract text is available yet for this article.
April 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28439399/posterior-reversible-encephalopathy-syndrome-with-colitis-in-a-patient-treated-with-panitumumab
#19
Céline Blaye, Xavier Buy, Marine Gross-Goupil, Didier Vincent, Claire Jamet, Paul Sargos, Stéphane Culine, Guilhem Roubaud
No abstract text is available yet for this article.
April 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28439398/a-practical-approach-to-the-pharmacological-management-of-hypertension-in-older-people
#20
REVIEW
Nikesh Parekh, Amy Page, Khalid Ali, Kevin Davies, Chakravarthi Rajkumar
Hypertension is the leading cause of cardiovascular (CV) morbidity and mortality in adults over the age of 65. The first part of this paper is an overview, summarizing the current guidelines on the pharmacological management of hypertension in older adults in Europe and the USA, and evidence from key trials that contributed to the guidelines. In the second part of the paper, we will discuss the major challenges of managing hypertension in the context of multimorbidity, including frailty, orthostatic hypotension (OH), falls and cognitive impairment that are associated with ageing...
April 2017: Therapeutic Advances in Drug Safety
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