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Food & Function

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https://www.readbyqxmd.com/read/30014084/major-compounds-of-red-ginseng-oil-attenuate-a%C3%AE-25-35-induced-neuronal-apoptosis-and-inflammation-by-modulating-mapk-nf-%C3%AE%C2%BAb-pathway
#1
Seonah Lee, Kumju Youn, Mira Jun
β-Amyloid (Aβ)-induced neuronal toxicity in Alzheimer's disease (AD) is associated with complex mechanisms. Thus, a multi-target approach might be suitable for AD treatment. Following our previous study on the neuroprotective effects of red ginseng oil extract, its major compounds, including linoleic acid (LA), β-sitosterol (BS), and stigmasterol (SS), were examined to elucidate the mechanism of anti-apoptosis and anti-inflammation in Aβ25-35-stimulated PC12 cells. The results showed that the three compounds mitigated Aβ25-35 toxicity by regulating oxidative stress, apoptotic responses, and pro-inflammatory mediators...
July 17, 2018: Food & Function
https://www.readbyqxmd.com/read/30011345/deconstructing-the-physical-processes-of-digestion-reductionist-approaches-may-provide-greater-understanding
#2
REVIEW
R G Lentle
I provide a broad overview of the physical factors that govern intestinal digestion i.e. the admixture of food particles in digesta with secreted enzymes and the subsequent mass transfer of liberated nutrients from the surfaces of particles to the gut wall, with a view to outlining the quantitative work that is required to determine the relative importance of these factors in the digestion of particular foods. I first discuss what is known of the mechanical forces generated by contraction of the walls of the various segments of the gut and the level of diffusive, and advective mixing that it generates within the lumen...
July 16, 2018: Food & Function
https://www.readbyqxmd.com/read/30010169/lactobacillus-plantarum-lc27-and-bifidobacterium-longum-lc67-mitigate-alcoholic-steatosis-in-mice-by-inhibiting-lps-mediated-nf-%C3%AE%C2%BAb-activation-through-restoration-of-the-disturbed-gut-microbiota
#3
Won-Gyeong Kim, Hye In Kim, Eun Kyung Kwon, Myung Joo Han, Dong-Hyun Kim
Long-term exposure to ethanol simultaneously causes gastrointestinal inflammation, liver injury, and steatosis. In the present study, we investigated the effects of Bifidobacterium longum LC67, Lactobacillus plantarum LC27, and their mixture (LM) against ethanol-induced steatosis in mice. Exposure to ethanol caused liver damage: it increased ALT, AST, TG, TC, and lipopolysaccharide levels in the blood and induced NF-κB activation in the liver. Oral administration of LC27, LC67, or LM in mice reduced ethanol-induced ALT, AST, TG, and TC levels in the blood and liver...
July 16, 2018: Food & Function
https://www.readbyqxmd.com/read/30009284/phenolics-from-eugenia-jambolana-seeds-with-advanced-glycation-endproduct-formation-and-alpha-glucosidase-inhibitory-activities
#4
Feifei Liu, Hang Ma, Guihua Wang, Weixi Liu, Navindra P Seeram, Yu Mu, Yingjie Xu, Xueshi Huang, Liya Li
Published data suggest that dietary-derived phenolics exert beneficial effects against hyperglycemia-mediated diseases, such as diabetes, through inhibiting the formation of advanced glycation endproducts (AGEs) and carbohydrate hydrolyzing enzyme activities. In the course of our investigation on the edible berry, Eugenia jambolana (known as Jamun), 21 phenolics (1-21) were isolated and identified from its seeds. Among these, one compound (1) is new and eleven compounds (3, 6, 9-13, 17, and 19-21) are being reported from E...
July 16, 2018: Food & Function
https://www.readbyqxmd.com/read/30004553/the-gut-microbiota-urolithin-metabotypes-revisited-the-human-metabolism-of-ellagic-acid-is-mainly-determined-by-aging
#5
A Cortés-Martín, R García-Villalba, A González-Sarrías, M Romo-Vaquero, V Loria-Kohen, A Ramírez-de-Molina, F A Tomás-Barberán, M V Selma, J C Espín
Understanding individuals' response to dietary bioactives is crucial for personalized nutrition. We report here for the first time in a Caucasian cohort (5-90 years, n = 839) that aging is the main factor that determines the gut microbiota involved in the ellagic acid-ellagitannin metabolism (urolithin metabotypes), with potential consequences for human health.
July 13, 2018: Food & Function
https://www.readbyqxmd.com/read/29999510/fatty-acid-positional-distribution-in-colostrum-and-mature-milk-of-women-living-in-inner-mongolia-north-jiangsu-and-guangxi-of-china
#6
Long Deng, Qian Zou, Biao Liu, Wenhui Ye, Chengfei Zhuo, Li Chen, Ze-Yuan Deng, Ya-Wei Fan, Jing Li
In order to investigate the fatty acid composition and distribution in colostrum and mature milk, breast milk samples and 24 h food records were obtained from 65 lactating women across three regions in China (Inner Mongolia, North Jiangsu and Guangxi). Fatty acid methyl esters were prepared by standard methods and separated and identified by gas chromatography. Compared with the Chinese breast milk fatty acid data 10 years ago, SFA and trans fatty acids (TFA) in breast milk decreased, while PUFA increased in the present study...
July 12, 2018: Food & Function
https://www.readbyqxmd.com/read/29999504/lactose-malabsorption-and-intolerance-a-review
#7
REVIEW
Santiago Ugidos-Rodríguez, María Cruz Matallana-González, María Cortes Sánchez-Mata
Food lactose and lactose intolerance are today hot topics in the field of food and nutrition. About 70% of the adult world population is lactose-intolerant, due to low levels of intestinal lactase, also called lactase-phlorizin hydrolase (LPH), a β-d-galactosidase found in the apical surface of the intestinal microvilli. This may be due to the loss of intestinal lactase in adulthood, a condition transmitted by an autosomal recessive gene, which differs in humans according to race. According to the cultural-historical hypothesis, the mutation that allows the metabolization of lactose appeared about 10 000 years ago in the inhabitants of Northern Europe where mammalian milk continued in the diet after weaning, and lactase-persistent populations were genetically selected in some areas...
July 12, 2018: Food & Function
https://www.readbyqxmd.com/read/29998274/epigallocatechin-gallate-induces-glut4-translocation-in-skeletal-muscle-through-both-pi3k-and-ampk-dependent-pathways
#8
Manabu Ueda-Wakagi, Kaori Hayashibara, Tomoya Nagano, Masaki Ikeda, Sihao Yuan, Shuji Ueda, Yasuhito Shirai, Ken-Ichi Yoshida, Hitoshi Ashida
Our previous report demonstrated that epigallocatechin gallate (EGCg) promotes translocation of glucose transporter 4 (GLUT4) in skeletal muscle. In this study, we investigated the molecular mechanism of GLUT4 translocation by EGCg at the physiological concentration range. In L6 cells, EGCg induced phosphorylation of phosphatidylinositide 3'-kinase (PI3K) and downstream protein kinase C (PKC) λ/ξ without affecting the phosphorylation of insulin receptor and Akt. EGCg-induced GLUT4 translocation was suppressed by RNA interference-mediated knockdown of PI3K and treatment with PKC inhibitor Go6983...
July 12, 2018: Food & Function
https://www.readbyqxmd.com/read/29995048/modulation-of-gut-microbiota-by-mulberry-fruit-polysaccharide-treatment-of-obese-diabetic-db-db-mice
#9
Chun Chen, Li-Jun You, Qiang Huang, Xiong Fu, Bin Zhang, Rui-Hai Liu, Chao Li
Increasing evidence indicates that gut microbiota is an important factor in mediating the development of metabolic disorders, especially type 2 diabetes. Herein, we investigated the protective effects of polysaccharides from mulberry fruit on diabetic db/db mice. We observed an inhibition in the body weight increase, a decrease in the blood glucose levels, and an improvement in glucose tolerance. Furthermore, our data showed increased enzymatic activities as evidenced by parameters such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT)...
July 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29993075/targeting-heme-oxygenase-1-by-quercetin-ameliorates-alcohol-induced-acute-liver-injury-via-inhibiting-nlrp3-inflammasome-activation
#10
Shu Liu, Lei Tian, Guangrui Chai, Bo Wen, Bingyuan Wang
Alcoholic hepatitis (AH) is characterized by inflammation and necrosis of liver tissue caused by excessive alcohol consumption and it even causes organ failure sometimes, in which oxidative stress plays an important role. Quercetin is a bioactive flavonoid in the class of polyphenols with a free-radical scavenging ability and anti-inflammatory activity. Recently it has aroused great interest because of its potential benefits in the prevention and intervention of cancer, cardiovascular abnormalities, neurodegenerative diseases, metabolic disorders and liver fibrosis...
July 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29993073/development-of-a-microparticulate-system-containing-brazilian-propolis-by-product-and-gelatine-for-ascorbic-acid-delivery-evaluation-of-intestinal-cell-viability-and-radical-scavenging-activity
#11
Lizziane Maria Belloto de Francisco, Diana Pinto, Hélen Cássia Rosseto, Lucas de Alcântara Sica de Toledo, Rafaela Said Dos Santos, Paulo Costa, Francisca Rodrigues, M Beatriz P P Oliveira, Bruno Sarmento, Marcos Luciano Bruschi
The use of propolis by-product (PBP) microparticles (MP) as delivery systems can be a promising tool to surpass drawbacks related to low stability of ascorbic acid (AA). The objective of this study was to develop and characterize MP prepared with PBP containing AA. The MP was characterized regarding morphology, particle size, polydispersity index (PDI), association efficiency (AE), drug loading (DL), infrared and Raman spectroscopy as well as antioxidant and radical scavenging activity, in vitro release, and cellular studies...
July 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29993072/involvement-of-autophagy-in-the-beneficial-effects-of-resveratrol-in-hepatic-steatosis-treatment-a-comparison-with-energy-restriction
#12
I Milton-Laskibar, L Aguirre, U Etxeberria, F I Milagro, J A Martínez, María P Portillo
Autophagy eliminates damaged cellular components. In the liver, it has been proposed that it mediates the breakdown of lipid droplets. This study aimed to compare the involvement of autophagy and the oxidative status in the effects of resveratrol and energy restriction as therapeutic tools for managing liver steatosis. In addition, potential additive or synergic effects were studied. Rats were fed a high-fat high-sucrose diet for 6 weeks and then divided into four experimental groups and fed a standard diet: a control group (C), a resveratrol-treated group (RSV, 30 mg kg-1 d-1), an energy restricted group (R, -15%), and an energy restricted group treated with resveratrol (RR)...
July 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29993054/lactoferrin-level-in-breast-milk-a-study-of-248-samples-from-eight-regions-in-china
#13
Xiaokun Cai, Yifan Duan, Yang Li, Jie Wang, Yingyi Mao, Zhenyu Yang, Xianfeng Zhao, Yanrong Zhao, Yan Guan, Shian Yin
Lactoferrin plays an important role in infant gastrointestinal health and immunity responses. This study measured the change of the lactoferrin level in breast milk over the lactation time in Chinese women, and explored potential influencing factors in terms of various maternal factors. 248 lactating women were recruited from eight different regions across China, covering 330 days of lactation. The nutrition information of each woman as well as the gender information of infants were collected. Breast milk lactoferrin level was determined by ultra-performance liquid chromatography (UPLC)...
July 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29989631/inhibition-of-%C3%AE-glucosidase-and-%C3%AE-amylase-by-flavonoid-glycosides-from-lu-an-guapian-tea-molecular-docking-and-interaction-mechanism
#14
Fang Hua, Peng Zhou, Hao-Yue Wu, Gang-Xiu Chu, Zhong-Wen Xie, Guan-Hu Bao
Green tea may favorably modulate blood glucose homeostasis, and regular consumption of green tea can prevent the development of type 2 diabetes mellitus. In this study, α-glucosidase and α-amylase inhibitory effects of the novel acylated flavonol tetraglycoside (camellikaempferoside C, 1) and 14 other flavone and flavone glycosides (FGs) isolated from Lu'an GuaPian (Camellia sinensis L.O. Kuntze) were evaluated. The kaempferol monoglycoside (15) showed inhibitory activity against α-glucosidase with IC50 at 40...
July 10, 2018: Food & Function
https://www.readbyqxmd.com/read/29987279/influence-of-thermal-processing-on-the-phase-behavior-of-a-novel-acylglyceride-alkylglyceride-lipid-based-delivery-system
#15
Pablo Arranz-Martínez, Marta Corzo-Martínez, Luis Vázquez, Carlos F Torres, Alejandro G Marangoni
Lipid-based delivery systems have been broadly utilized to enhance bioavailability and bioaccessibility properties of drugs. Loading capacity and drug stability within the lipid matrix is influenced by the phase behavior of the lipid components that make up the vehicle. In this study we have investigated the influence of thermal processing at 50 °C on the subsequent phase behavior of a lipid-based delivery system comprised of a blend of monoacylglycerols, diacylglycerols, monoalkylglycerols and dialkylglycerols obtained by enzymatic glycerolysis of ratfish liver oil...
July 10, 2018: Food & Function
https://www.readbyqxmd.com/read/29978874/dietary-methionine-restriction-regulated-energy-and-protein-homeostasis-by-improving-thyroid-function-in-high-fat-diet-mice
#16
Yuhui Yang, Jiahong Zhang, Guoqing Wu, Jin Sun, Yanan Wang, Haitao Guo, Yonghui Shi, Xiangrong Cheng, Xue Tang, Guowei Le
Methionine-restricted diets (MRD) show an integrated series of beneficial health effects, including improving insulin sensitivity, limiting fat deposition, and decreasing oxidative stress, and inflammation responses. We aimed to explore the systemic responses to a MRD in mice fed with a high fat (HFD) and clarify the possible mechanism. Mice were fed with a control diet (0.86% methionine + 4% fat, CON), HFD (0.86% methionine + 20% fat), or MRD (0.17% methionine + 20% fat) for 22 consecutive weeks. HFD-fed mice showed widespread systemic metabolic disorders and thyroid dysfunction...
July 6, 2018: Food & Function
https://www.readbyqxmd.com/read/29978873/correction-hibiscus-and-lemon-verbena-polyphenols-modulate-appetite-related-biomarkers-in-overweight-subjects-a-randomized-controlled-trial
#17
Marina Boix-Castejón, María Herranz-López, Alberto Pérez Gago, Mariló Olivares-Vicente, Nuria Caturla, Enrique Roche, Vicente Micol
Correction for 'Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial' by Marina Boix-Castejón et al., Food Funct., 2018, 9, 3173-3184.
July 6, 2018: Food & Function
https://www.readbyqxmd.com/read/29978871/enhancing-the-health-potential-of-processed-meat-the-effect-of-chitosan-or-carboxymethyl-cellulose-enrichment-on-inherent-microstructure-water-mobility-and-oxidation-in-a-meat-based-food-matrix
#18
Minyi Han, Mathias P Clausen, Morten Christensen, Els Vossen, Thomas Van Hecke, Hanne Christine Bertram
The addition of dietary fibers can alleviate the deteriorated textural properties and water binding capacity (WBC) that may occur when the fat content is lowered directly in the formulas of comminuted meat products. This study investigated the effects of the addition of chitosan or carboxymethyl cellulose (CMC) (2% w/w) to a model meat product. Both dietary fibers improved the water-binding capacity (WBC), while chitosan addition resulted in a firmer texture, CMC lowered the hardness. Chitosan addition resulted in a 2-fold reduction of lipid oxidation products, whereas CMC had no significant effect on oxidation...
July 6, 2018: Food & Function
https://www.readbyqxmd.com/read/29978173/sour-cherry-extract-inhibits-human-salivary-%C3%AE-amylase-and-growth-of-streptococcus-mutans-a-pilot-clinical-study
#19
Judit Homoki, Gyöngyi Gyémánt, Péter Balogh, László Stündl, Piroska Bíró-Molnár, Melinda Paholcsek, Judit Váradi, Fenyvesi Ferenc, Barna Kelentey, Judit Nemes, Judit Remenyik
The purpose of this study was to determine whether cherry extract has any effect on salivary α-amylase activity (sAA) or on the level of Streptococcus mutans in human saliva. 70 patients (45 females and 25 males) in three age groups (22 children, 25 young adults, and 23 adults) were examined. All participants completed a questionnaire to obtain information on their oral health behaviour and life style. Clinical examination was performed to record the number of decayed, missing and filled teeth (DMF-T). Saliva samples were collected for the measurement of sAA and the salivary S...
July 6, 2018: Food & Function
https://www.readbyqxmd.com/read/29978171/preclinical-safety-evaluation-of-the-ethanolic-extract-from-campomanesia-pubescens-mart-ex-dc-o-berg-guavira-fruits-analysis-of-genotoxicity-and-clastogenic-effects
#20
Gustavo Roberto Villas Boas, Flávio Henrique Souza de Araújo, Jhony Moreira Marcelino, Luis Henrique Almeida Castro, Ana Paula Stefanello da Silveira, Renato Silva Nacer, Fabio Rodrigues de Souza, Claudia Andréa Lima Cardoso, Roseli Boerngen de Lacerda, Zaira da Rosa Guterres, Silvia Aparecida Oesterreich
Genotoxicity studies of plants with medicinal and nutritional properties are recommended by international regulatory agencies as part of the risk assessment. Due to their consumption as food, nutraceutical use and ethnopharmacological relevance, Campomanesia pubescens represents one of these plants to be studied. The aim of the present study was to evaluate the genotoxic, cytotoxic potential and clathogenic effects of the ethanolic extract obtained from the pulp of C. pubescens (EEFCP) fruits on rats submitted to experimental genotoxicity models and through the SMART test performed in Drosophila melanogaster...
July 6, 2018: Food & Function
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