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Food & Function

Guangguo Tan, Xin Wang, Kui Liu, Xin Dong, Wenting Liao, Hong Wu
Screening active constituents of traditional Chinese medicines (TCMs) is vital for lead compound discovery. Sini decoction (SND) is a well-known TCM formula for relieving myocardial ischemia (MI) in clinic. Due to complex nature, the effective compounds of SND are still unknown. In this study, a novel "system to system" strategy based on the correlation of drug-related and drug-induced ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOFMS) serum metabolomic profiles was developed to discover bioactive compounds of SND against isoproterenol-induced MI...
September 13, 2018: Food & Function
Eliana Pereira, Andreia I Pimenta, Lillian Barros, Ricardo C Calhelha, Amilcar L Antonio, Sandra Cabo Verde, Isabel C F R Ferreira
Irradiation is a feasible and safe decontamination technique, being applied to several types of foods including edible and medicinal plants. The aim of this study was to evaluate the effects of different gamma radiation doses (1, 5 and 10 kGy) on the individual profile of phenolic compounds determined by HPLC-DAD-ESI/MS, and the bioactive potential (cytotoxic, virucidal, and antimicrobial activities) of Aloysia citrodora Paláu (lemon verbena), Mentha × piperita L. (peppermint) and Thymus vulgaris L. (thyme)...
September 13, 2018: Food & Function
Yang Wang, Yang-Jia Li, Xiao-Hui Huang, Can-Can Zheng, Xing-Feng Yin, Bin Li, Qing-Yu He
SCOPE: Colorectal cancer (CRC) is one of the most common cancers worldwide with poor survival and limited therapeutic options, and there is an urgent need to develop novel therapeutic agents with good treatment efficiency and low toxicity. This study aims to examine the anticancer bioactivity of liensinine, a constituent of Nelumbo nucifera Gaertn, in CRC and investigate the action mechanisms involved. METHODS AND RESULTS: Liensinine was found to induce apoptosis and exert a significant inhibitory effect on the proliferation and colony-forming ability of CRC cells in a dose-dependent manner without any observed cytotoxicity on normal colorectal epithelial cells...
September 12, 2018: Food & Function
Yannan Liu, Daidi Fan
Breast cancer is the most frequently diagnosed cancer and has become the main cause of cancer-related death among women worldwide. Traditional chemotherapy for breast cancer has serious side effects for patients, such as the first-line drug docetaxel. Ginsenoside Rg5, a rare ginsenoside and the main ingredient extracted from fine black ginseng, has been proved to have anti-breast cancer efficacy in vitro. Here, the in vivo anti-breast cancer efficacy, side effects and potential molecular mechanisms of Rg5 were investigated on a BALB/c nude mouse model of human breast cancer...
September 12, 2018: Food & Function
Zongyuan Wu, Zumeng Xia, Bangfu Wu, Fang Wei, Xin Lv, Ya Xie, Shuling Xu, Jiqu Xu, Hong Chen, Fenghong Huang
Atherosclerosis is a chronic disease associated with oxidative stress and inflammatory activation and is the main underlying trigger for cardiovascular disease. There are many cardiovascular health products in the market; in order to evaluate the effect of these products, in this paper, a novel lipid profiling platform was established using the shot-gun mass spectrum method for the analysis of free fatty acid and phospholipids, and the high performance liquid chromatography coupled with mass spectroscopy method for the analysis of lipid mediators and triacylglycerol, respectively, in serum from male apolipoprotein E-knock out mice after different diet interventions...
September 12, 2018: Food & Function
Shireen Attaran, Wallace Yokoyama, James Pan, Jose De J Berrios
Insulin resistance, obesity and dyslipidemia are the main physiological factors associated with metabolic syndrome. The objectives of this study were to understand the effects of diets containing extruded lentil fortified with high chromium nutritional yeast (YCr) or chromium picolinate on glucose tolerance, clearance and fasting blood glucose concentrations in Normal and Obese (Ob/Ob) mice and to determine the effects of the diets on the mice plasma lipid profiles. Diets A, B and C contained YCr in different doses and concentrations, as follows: Diet A = 15...
September 12, 2018: Food & Function
Kanyasiri Rakariyatham, Xian Wu, Zhonghai Tang, Yanhui Han, Qi Wang, Hang Xiao
Luteolin and sulforaphane are well-known food bioactives with anti-inflammatory properties. Herein, we determined their combinational effects in inhibiting inflammation in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Both luteolin and sulforaphane showed dose-dependent inhibition on LPS-induced production of nitric oxide (NO) in the macrophages. The combined treatments led to a stronger inhibition on NO production compared to the singular treatments. Isobologram analysis confirmed that the combined treatments produced a synergy...
September 12, 2018: Food & Function
Andrea Alvarez-Sala, Virginia Blanco-Morales, Antonio Cilla, Ramona Ángeles Silvestre, Elena Hernández-Álvarez, Fernando Granado-Lorencio, Reyes Barberá, Guadalupe Garcia-Llatas
The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women (n = 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL-1) in serum total cholesterol (pre-treatment: 220...
September 12, 2018: Food & Function
Yingyun Chen, Xiang Gao, Yuxi Wei, Qi Liu, Yuhong Jiang, Ling Zhao, Sadeeq Ulaah
Hypertension is known as an important factor in cardiovascular disease. An angiotensin-I-converting enzyme (ACE) inhibitor is one of the synthetic drugs that is widely used to control hypertension. Here, we have prepared and investigated the ACE inhibitory peptide from Ruditapes philippinarum fermented with Bacillus natto. The fermented product obtained under optimized fermentation conditions exhibited ACE inhibitory activity. The ACE inhibitory peptides were purified by ultrafiltration, gel filtration chromatography and RP-HPLC, sequentially...
September 12, 2018: Food & Function
Shengwei Sun, Fei Liu, Guo Liu, Jianyin Miao, Hang Xiao, Jie Xiao, Zhirou Qiu, Zhen Luo, Jian Tang, Yong Cao
Casein phosphopeptides (CPPs) are a series of peptides containing serine phosphate, which prevents calcium precipitation in the small intestine, so that it can be absorbed. Calcium metabolism studies have been typically carried out using traditional metabolic balance tests. Non-radioactive stable isotopes have rarely been used to examine the in vivo absorption and metabolism of calcium in animal models due to their high cost and the difficulty in their accurate detection. However, they have recently attracted intense research attention...
September 12, 2018: Food & Function
Zack C F Wong, Gallant K L Chan, Kevin Q Y Wu, Karman K M Poon, Yicun Chen, Tina T X Dong, Karl W K Tsim
Edible bird's nest (EBN), an Asian health food, contains insoluble proteins and conjugated N-acetylneuraminic acid (NANA) that are difficult to be absorbed by humans. In order to increase the nutritional value of EBN, we developed methods to digest EBN targeting the release of proteins and NANA. By using simulated gastric fluid under acidic conditions, the complex proteins were fully digested into smaller peptides, and in parallel, NANA was fully released from the conjugated form. The completely digested EBN showed better nutraceutical properties...
September 12, 2018: Food & Function
Paula Mapelli-Brahm, Carla M Stinco, Antonio J Meléndez-Martínez
The objective was to assess the potential bioavailability of phytoene (PT) and phytofluene (PTF) from tomato powders used as raw materials for supplements as compared to the pulp of a common tomato and a cherry tomato. PT and PTF are attracting much interest nowadays as they can provide health and cosmetic benefits. PT and PTF levels in the more concentrated powder were up to 1000 times higher than in the tomatoes. The bioaccessibility from the powders was lower as compared to the tomato fruits and increased markedly when sunflower oil was added...
September 7, 2018: Food & Function
Zheng-Nan Cai, Wan Li, Shomaila Mehmood, Wen-Juan Pan, Qing-Xi Wu, Yan Chen, Yong-Ming Lu
Polysaccharides from Morchella esculenta are known to exhibit diverse bioactivities, while an anti-melanogenesis effect has been barely addressed. Herein, the anti-melanogenesis activity of a heteropolysaccharide from M. esculenta (FMP-1) was investigated in vitro and in vivo. FMP-1 had no significant cytotoxic effect on B16F10 melanoma cells as well as zebrafish larvae, but did reduce melanin contents and tyrosinase activities in both of them. Treatment with FMP-1 also effectively suppressed the expression of melanogenesis-related proteins, including MC1R, MITF, TRP-1 and TRP-2, through decreasing the phosphorylation of cyclic adenosine monophosphate response element-binding protein (CREB)...
September 6, 2018: Food & Function
Lin Han, Lingling Zhang, Wenfang Ma, Ding Li, Rujie Shi, Min Wang
As a dimer of proanthocyanidin, proanthocyanidin B2 (PB2) was found to effectively attenuate postprandial blood glucose in mice after sucrose loading. Further studies showed that PB2 revealed strong inhibitory activity against α-glucosidase with an IC50 value of (0.23 ± 0.01) μg mL-1, and this process was reversible with a mixed-type inhibitory manner. PB2 quenched the intrinsic fluorescence of α-glucosidase through a static quenching mechanism and changed the micro-environments and conformations of α-glucosidase that led to an aggregation phenomenon...
September 6, 2018: Food & Function
Ning Zhou, Meng-Nan Zeng, Kai Li, Yan-Yun Yang, Zhi-Yao Bai, Xiao-Ke Zheng, Wei-Sheng Feng
Chinese yam (CY), used as both a traditional Chinese medicine and a nutritious food, is an excellent candidate for treating septic cardiomyopathy (SCM). Adenosine, arbutin and allantoin are the major active components in the aqueous extract of CY. The aim of the present study was to interpret the roles of CY, adenosine, arbutin and allantoin in SCM treatment. Firstly, significant physiological indexes were examined to assess the model and treatment effects of CY, adenosine, arbutin and allantoin. Then, a metabolomic approach was utilized to reveal the metabolic disorders in SCM concerning the intervention of CY/adenosine/arbutin/allantoin...
September 6, 2018: Food & Function
Peng Bin, Md Abul Kalam Azad, Gang Liu, Dan Zhu, Sung Woo Kim, Yulong Yin
Fetal growth, survival, and development are benchmarks for the production performance of sows, and methionine has been shown to impact fetal protein mass and the transport of nutrients through the uteroplacental vasculature. This study evaluated the effects of dietary methionine, administered during the late gestation period, on the production performance of sows. Specifically, it measured the effect of methionine on biochemical indicators in the plasma, plasma metabolites, and fecal bacterial communities. Thirty Landrace × Large White sows at day 90 of gestation were randomly assigned to three groups and fed the following diets: (1) a basal diet containing 0...
September 6, 2018: Food & Function
Ning Li, Qingyu Zhang, Zhenbin Jia, Xiaohong Yang, Haitao Zhang, Hui Luo
The anti-lung cancer activity of volatile oil from Alpinia officinarum (VOAO) and the underlying mechanism has not been studied. Herein, VOAO was extracted by steam distillation and its components were identified by GC-MS analysis. Cells viability was measured by an MTT assay and the cell survival capacity was tested via a colony formation assay. Apoptosis cells were detected using the Annexin V-FITC/PI method. Hoechst 33342 cell unclear staining was employed to evaluate the nuclear morphology change. The mitochondrial membrane potential was detected by a JC-1 staining assay...
September 6, 2018: Food & Function
Dalila Ghouti, Wahiba Rached, Moussaoui Abdallah, Tânia C S P Pires, Ricardo C Calhelha, Maria José Alves, Lazzouni Hamadi Abderrahmane, Lillian Barros, Isabel C F R Ferreira
The aim of this study was to characterize the individual phenolic profile and antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities of hydroethanolic and infusion extracts prepared from Algerian Saharan Juniperus phoenicea L. and Cotula cinerea (Del). The phenolic profile was determined using a liquid chromatograph coupled to a diode array detector and an electrospray ionization mass spectrometer (LC-DAD-ESI/MS). A total of thirteen and nine individual phenolic compounds were identified in J...
September 6, 2018: Food & Function
Yong Zhang, Yu Wang, Daiwen Chen, Bing Yu, Ping Zheng, Xiangbing Mao, Yuheng Luo, Yan Li, Jun He
Chlorogenic acid (CGA), an ester formed between caffeic acid and quinic acid, is one of the most abundant phenolic acids and is widespread in fruits, vegetables, cereals and tuber crops. Therefore, the present study was conducted to test the hypothesis that dietary supplementation with CGA could improve intestinal health and regulate intestinal selected microbiota in weaned piglets. A total of twenty-four piglets (21 d of age) were randomly assigned to one of four groups according to their initial BW and sex and fed a basal diet (control group) or a basal diet containing 250, 500 and 1000 mg kg-1 CGA, respectively...
September 5, 2018: Food & Function
Carine Smith, Amanda Swart
Increasing consumer bias toward natural products and the considerable wealth of indigenous knowledge has precipitated an upturn in market-driven research into potentially beneficial medicinal plants. In this context, Aspalathus linearis (Rooibos) has been identified to be a promising candidate which may impact cardiovascular disease (CVD), which is one of the most widely studied chronic diseases of modern times. Despite these efforts, ischemic heart disease remains the number one cause of mortality globally...
September 5, 2018: Food & Function
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