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World Journal of Diabetes

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https://www.readbyqxmd.com/read/28572883/impact-of-creatinine-methodology-on-glomerular-filtration-rate-estimation-in-diabetes
#1
Marijana Vučić Lovrenčić, Vanja Radišić Biljak, Kristina Blaslov, Sandra Božičević, Lea Smirčić Duvnjak
AIM: To evaluate the influence of creatinine methodology on the performance of chronic kidney disease (CKD)-Epidemiology Collaboration Group-calculated estimated glomerular filtration rate (CKD-EPI-eGFR) for CKD diagnosis/staging in a large cohort of diabetic patients. METHODS: Fasting blood samples were taken from diabetic patients attending our clinic for their regular annual examination, including laboratory measurement of serum creatinine and eGFR. RESULTS: Our results indicated an overall excellent agreement in CKD staging (kappa = 0...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572882/nonsurgical-periodontal-therapy-improves-glycosylated-hemoglobin-levels-in-pre-diabetic-patients-with-chronic-periodontitis
#2
Rosamma Joseph, Meera Sasikumar, Jerry Mammen, M G Joseraj, Chandni Radhakrishnan
AIM: To evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis (CHP). METHODS: Sixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters (plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin (HbA1c), fasting lipid profile, and fasting blood glucose]...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572881/association-between-dairy-intake-lipids-and-vascular-structure-and-function-in-diabetes
#3
Kristina S Petersen, Jennifer B Keogh, Natalie Lister, Jacquelyn M Weir, Peter J Meikle, Peter M Clifton
AIM: To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and function. METHODS: A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes (n = 108)...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572880/effect-of-medicinal-mushrooms-on-blood-cells-under-conditions-of-diabetes-mellitus
#4
REVIEW
Taras Vitak, Borys Yurkiv, Solomon Wasser, Eviatar Nevo, Natalia Sybirna
Diabetes mellitus (DM) is the third most common non-infectious disease leading to early disability and high mortality. Moreover, the number of patients is growing every year. The main symptom of DM is hyperglycemia. Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules. This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of micro- and macroangiopathies...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572879/effects-of-glycaemic-management-on-diabetic-kidney-disease
#5
REVIEW
Richard J MacIsaac, George Jerums, Elif I Ekinci
Hyperglycaemia contributes to the onset and progression of diabetic kidney disease (DKD). Observational studies have not consistently demonstrated a glucose threshold, in terms of HbA1c levels, for the onset of DKD. Tight glucose control has clearly been shown to reduce the incidence of micro- or macroalbuminuria. However, evidence is now also emerging to suggest that intensive glucose control can slow glomerular filtration rate loss and possibly progression to end stage kidney disease. Achieving tight glucose control needs to be balanced against the increasing appreciation that glucose targets for the prevention of diabetes related complications need be individualised for each patient...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465793/kmap-o-framework-for-care-management-research-of-patients-with-type-2-diabetes
#6
Thomas T H Wan, Amanda Terry, Bobbie McKee, Waleed Kattan
AIM: To review impacts of interventions involving self-management education, health coaching, and motivational interviewing for type 2 diabetes. METHODS: A thorough review of the scientific literature on diabetes care and management was executed by a research team. RESULTS: This article summarizes important findings in regard to the validity of developing a comprehensive behavioral system as a framework for empirical investigation. The behavioral system framework consists of patients' knowledge (K), motivation (M), attitude (A), and practice (P) as predictor variables for diabetes care outcomes (O)...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465792/effects-of-intermittent-fasting-on-health-markers-in-those-with-type-2-diabetes-a-pilot-study
#7
Terra G Arnason, Matthew W Bowen, Kerry D Mansell
AIM: To determine the short-term biochemical effects and clinical tolerability of intermittent fasting (IF) in adults with type 2 diabetes mellitus (T2DM). METHODS: We describe a three-phase observational study (baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements (using the Yale Physical Activity Survey) were taken at the end of each phase...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465791/insulin-mimetic-compound-hexaquis-benzylammonium-decavanadate-is-antilipolytic-in-human-fat-cells
#8
Christian Carpéné, Silvia Garcia-Vicente, Marta Serrano, Luc Marti, Chloé Belles, Miriam Royo, Jean Galitzky, Antonio Zorzano, Xavier Testar
AIM: To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate (B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids (FFA) and glucose circulating levels. METHODS: Adipose tissue (AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents (insulin, benzylamine, vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465790/osteomyelitis-in-diabetic-foot-a-comprehensive-overview
#9
REVIEW
Laura Giurato, Marco Meloni, Valentina Izzo, Luigi Uccioli
Foot infection is a well recognized risk factor for major amputation in diabetic patients. The osteomyelitis is one of the most common expression of diabetic foot infection, being present approximately in present in 10%-15% of moderate and in 50% of severe infectious process. An early and accurate diagnosis is required to ensure a targeted treatment and reduce the risk of major amputation. The aim of this review is to report a complete overview about the management of diabetic foot osteomyelitis. Epidemiology, clinical aspects, diagnosis and treatment are widely described according to scientific reccomendations and our experience...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465789/syndecan-1-coating-of-interleukin-17-producing-natural-killer-t-cells-provides-a-specific-method-for-their-visualization-and-analysis
#10
REVIEW
Anil Kumar Jaiswal, Mohanraj Sadasivam, Abdel Rahim A Hamad
Natural killer T cells (NKT cells) are innate-like T cells that acquire effector functions while developing in the thymus, polarize into three distinct functional subsets viz. NKT1, NKT2 and NKT17 cells that produce interferon (IFN)-γ, interleukin (IL)-4 and IL-17, respectively. However, there has been no unique surface markers that define each subsets, forcing investigators to use intracellular staining of transcription factors and cytokines in combination of surface markers to distinguish among these subsets...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465788/type-2-diabetes-and-quality-of-life
#11
REVIEW
Aikaterini Trikkalinou, Athanasia K Papazafiropoulou, Andreas Melidonis
It is true that a primary goal of diabetes early diagnosis and treatment is quality of life (QoL). The term QoL is still confusing but it is agreed that it composes of four components: The physical component, mental, cogitative component, psychological and social component. Many articles have been written addressing those four components. During the last five years 15500 articles and reviews have been written addressing diabetes and coronary arterial disease, 16100 addressing diabetes and renal function, 28900 addressing diabetes and retinopathy, 16800 addressing diabetic foot ulcers and other 26300 addressing diabetic neuropathy...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28344754/role-of-angiotensin-converting-enzyme-and-angiotensinogen-gene-polymorphisms-in-angiotensin-converting-enzyme-inhibitor-mediated-antiproteinuric-action-in-type-2-diabetic-nephropathy-patients
#12
Neerja Aggarwal, Pawan Kumar Kare, Parul Varshney, Om Prakash Kalra, Sri Venkata Madhu, Basu Dev Banerjee, Anil Yadav, Alpana Raizada, Ashok Kumar Tripathi
AIM: To investigate the role of genetic variants of angiotensin converting enzyme (ACE) and angiotensinogen (AGT) genes in the antiproteinuric efficacy of ACE inhibitor therapy in diabetic nephropathy (DN) patients. METHODS: In the present study, 270 type 2 diabetes mellitus patients with nephropathy were enrolled and treated with ACE inhibitor (ramipril) and followed at 6 mo for renal function and albumin excretion by estimating serum creatinine, end stage renal disease, and albumin/creatinine ratio (ACR) in urine...
March 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28344753/statin-testosterone-and-phosphodiesterase-5-inhibitor-treatments-and-age-related-mortality-in-diabetes
#13
Geoffrey Hackett, Peter W Jones, Richard C Strange, Sudarshan Ramachandran
AIM: To determine how statins, testosterone (T) replacement therapy (TRT) and phosphodiesterase 5-inhibitors (PDE5I) influence age related mortality in diabetic men. METHODS: We studied 857 diabetic men screened for the BLAST study, stratifying them (mean follow-up = 3.8 years) into: (1) Normal T levels/untreated (total T > 12 nmol/L and free T > 0.25 nmol/L), Low T/untreated and Low T/treated; (2) PDE5I/untreated and PDE5I/treated; and (3) statin/untreated and statin/treated groups...
March 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28344752/involvement-of-cbl-b-mediated-macrophage-inactivation-in-insulin-resistance
#14
REVIEW
Tomoki Abe, Katsuya Hirasaka, Takeshi Nikawa
Aging and overnutrition cause obesity in rodents and humans. It is well-known that obesity causes various diseases by producing insulin resistance (IR). Macrophages infiltrate the adipose tissue (AT) of obese individuals and cause chronic low-level inflammation associated with IR. Macrophage infiltration is regulated by the chemokines that are released from hypertrophied adipocytes and the immune cells in AT. Saturated fatty acids are recognized by toll-like receptor 4 (TLR4) and induce inflammatory responses in AT macrophages (ATMs)...
March 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28344751/management-of-critically-ill-patients-with-diabetes
#15
REVIEW
Livier Josefina Silva-Perez, Mario Alberto Benitez-Lopez, Joseph Varon, Salim Surani
Disorders of glucose homeostasis, such as stress-induced hypoglycemia and hyperglycemia, are common complications in patients in the intensive care unit. Patients with preexisting diabetes mellitus (DM) are more susceptible to hyperglycemia, as well as a higher risk from glucose overcorrection, that may results in severe hypoglycemia. In critically ill patients with DM, it is recommended to maintain a blood glucose range between 140-180 mg/dL. In neurological patients and surgical patients, tighter glycemic control (i...
March 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28265346/fuzzy-expert-system-for-diagnosing-diabetic-neuropathy
#16
Meysam Rahmani Katigari, Haleh Ayatollahi, Mojtaba Malek, Mehran Kamkar Haghighi
AIM: To design a fuzzy expert system to help detect and diagnose the severity of diabetic neuropathy. METHODS: The research was completed in 2014 and consisted of two main phases. In the first phase, the diagnostic parameters were determined based on the literature review and by investigating specialists' perspectives (n = 8). In the second phase, 244 medical records related to the patients who were visited in an endocrinology and metabolism research centre during the first six months of 2014 and were primarily diagnosed with diabetic neuropathy, were used to test the sensitivity, specificity, and accuracy of the fuzzy expert system...
February 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28265345/exercise-induced-albuminuria-vs-circadian-variations-in-blood-pressure-in-type-1-diabetes
#17
Isabelle Hota Tadida Meli, Aurel T Tankeu, Mesmin Y Dehayem, David Chelo, Jean Jacques N Noubiap, Eugene Sobngwi
AIM: To investigated the relationship between exercise-induced ambulatory blood pressure measurement (ABPM) abnormalities in type 1 diabetes mellitus (T1DM) adolescents. METHODS: We conducted a case-control at the National Obesity Center of the Yaoundé Central Hospital, Cameroon. We compared 24 h ABPM and urinary albumin-to-creatinine ratio (ACR) at rest and after a standardized treadmill exercise between 20 Cameroonian T1DM patients and 20 matched controls. T1DM adolescents were aged 12-18 years, with diabetes for at least one year, without proteinuria, with normal office blood pressure (BP) and renal function according to the general reference population...
February 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28265344/association-of-nfkb1-gene-polymorphism-rs28362491-with-levels-of-inflammatory-biomarkers-and-susceptibility-to-diabetic-nephropathy-in-asian-indians
#18
Amar Gautam, Stuti Gupta, Mohit Mehndiratta, Mohini Sharma, Kalpana Singh, Om P Kalra, Sunil Agarwal, Jasvinder K Gambhir
AIM: To investigate the association of NFKB1 gene -94 ATTG insertion/deletion (rs28362491) polymorphism with inflammatory markers and risk of diabetic nephropathy in Asian Indians. METHODS: A total of 300 subjects were recruited (100 each), normoglycemic, (NG); type 2 diabetes mellitus (T2DM) without any complications (DM) and T2DM with diabetic nephropathy [DM-chronic renal disease (CRD)]. Analysis was carried out by polymerase chain reaction-restriction fragment length polymorphism and ELISA...
February 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28265343/high-fat-diet-dysregulates-microrna-17-5p-and-triggers-retinal-inflammation-role-of-endoplasmic-reticulum-stress
#19
Maha Coucha, Islam N Mohamed, Sally L Elshaer, Osinakachuk Mbata, Megan L Bartasis, Azza B El-Remessy
AIM: To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS: Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid (PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin (BSA) (400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice...
February 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28265342/integrating-insulin-like-growth-factor-1-and-sex-hormones-into-neuroprotection-implications-for-diabetes
#20
REVIEW
Jacob Huffman, Christina Hoffmann, George T Taylor
Brain integrity and cognitive aptitude are often impaired in patients with diabetes mellitus, presumably a result of the metabolic complications inherent to the disease. However, an increasing body of evidence has demonstrated the central role of insulin-like growth factor 1 (IGF1) and its relation to sex hormones in many neuroprotective processes. Both male and female patients with diabetes display abnormal IGF1 and sex-hormone levels but the comparison of these fluctuations is seldom a topic of interest. It is interesting to note that both IGF1 and sex hormones have the ability to regulate phosphoinositide 3-kinase-Akt and mitogen-activated protein kinases-extracellular signal-related kinase signaling cascades in animal and cell culture models of neuroprotection...
February 15, 2017: World Journal of Diabetes
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