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World Journal of Diabetes

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https://www.readbyqxmd.com/read/28751962/autologous-bone-marrow-derived-stem-cell-therapy-in-patients-with-type-2-diabetes-mellitus-defining-adequate-administration-methods
#1
Vikas Sood, Anil Bhansali, Bhagwant Rai Mittal, Baljinder Singh, Neelam Marwaha, Ashish Jain, Niranjan Khandelwal
AIM: To carry out randomized trial for evaluating effects of autologous bone marrow derived stem cell therapy (ABMSCT) through different routes. METHODS: Bone marrow aspirate was taken from the iliac crest of patients. Bone marrow mononuclear cells were separated and purified using centrifugation. These cells were then infused in a total of 21 patients comprising three groups of 7 patients each. Cells were infused into the superior pancreaticoduodenal artery (Group I), splenic artery (Group II) and through the peripheral intravenous route (Group III)...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751961/effect-of-bariatric-surgery-on-adiposity-and-metabolic-profiles-a-prospective-cohort-study-in-middle-eastern-patients
#2
Mohsen Mazidi, Peyman Rezaie, Ali Jangjoo, Alireza Tavassoli, Mohammad Taghi Rajabi, Andre Pascal Kengne, Mohsen Nematy
AIM: To investigate changes in adiposity and cardio-metabolic risk profile following Roux-en-Y gastric bypass in patients of Middle Eastern ethnicity with severe obesity. METHODS: This prospective cohort study involved 92 patients who met the indications of bariatric surgery. Post-procedure markers of obesity and cardiometabolic profile were monitored regularly for a year. RESULTS: Mean body mass index decreased by 29.5% from 41.9 to 29.5 kg/m(2) between baseline and 12-mo follow-up, while mean fat mass decreased by 45...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751960/are-body-mass-index-and-waist-circumference-significant-predictors-of-diabetes-and-prediabetes-risk-results-from-a-population-based-cohort-study
#3
Fahimeh Haghighatdoost, Masoud Amini, Awat Feizi, Bijan Iraj
AIM: To determine the predictive role of body mass index (BMI) and waist circumference (WC) for diabetes and prediabetes risk in future in total sample as well as in men and women separately. METHODS: In a population based cohort study, 1765 with mean ± SD age: 42.32 ± 6.18 healthy participants were followed up from 2003 till 2013 (n = 960). Anthropometric and biochemical measures of participants were evaluated regularly during the follow up period. BMI and WC measures at baseline and diabetes and prediabetes status of participants at 2013 were determined...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751959/quality-of-sleep-and-its-determinants-among-people-with-type-2-diabetes-mellitus-in-northwest-of-iran
#4
Seyed Morteza Shamshirgaran, Jafar Ataei, Ayyoub Malek, Manochehr Iranparvar-Alamdari, Nayyereh Aminisani
AIM: To examine sleep quality and its determinants among people with type 2 diabetes mellitus (T2DM). METHODS: This is a cross-sectional study conducted among diabetic patients referring to Ardabil diabetes clinic in Northwest of Iran. Information on sleep quality was collected using Pittsburg Sleep Quality Index (PSQI). A questionnaire was used to collect data on sociodemographic lifestyle factors and psychological distress. This questionnaire was completed through an interview, and clinical information was extracted from patient's record...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751958/type-2-diabetes-in-a-senegalese-rural-area
#5
Priscilla Duboz, Gilles Boëtsch, Lamine Gueye, Enguerran Macia
AIM: To estimate the prevalence of diabetes in the rural population of Tessekere (Senegal) and investigate associated risk factors. METHODS: Data from a 2015 survey of 500 individuals age 20 and over representative of the population of the municipality of Tessekere were used. Sociodemographic characteristics, health related variables, capillary whole blood glucose, and weight and height measurements of individuals were collected during face-to-face interviews. Statistical analyses used were bivariate tests and binary logistic regressions...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751957/vitamin-d-levels-in-subjects-with-or-without-chronic-kidney-disease-among-veterans-with-diabetes-in-north-east-united-states
#6
Subhashini Yaturu, Barbara Youngberg, Sonya Zdunek
AIM: To evaluate the prevalence of vitamin D deficiency and its relation to diabetes and kidney disease in Veterans residing in the North East United States (VISN 2). METHODS: In this retrospective study, we used data from the computerized patient record system at Stratton Veterans Administration Medical Center at Albany, NY (VHA) for those patients who had 25-hydroxyvitamin D levels and 1,25 (OH) vitamin D levels measured between 2007 and 2010. We collected demographic information including age, sex, body mass index and race; clinical data including diabetes, hypertension and CAD; and laboratory data including calcium, creatinine and parathyroid hormone (PTH) (intact)...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751956/saponins-as-adipokines-modulator-a-possible-therapeutic-intervention-for-type-2-diabetes
#7
REVIEW
Olusola Olalekan Elekofehinti, Oluwamodupe Cecilia Ejelonu, Jean Paul Kamdem, Oluwaseun Benedicta Akinlosotu, Isaac Gbadura Adanlawo
Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we summarized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751955/ptpn22-and-islet-specific-autoimmunity-what-have-the-mouse-models-taught-us
#8
REVIEW
Giuseppe Galvani, Georgia Fousteri
An allelic variant of the protein tyrosin phosphatase non-receptor 22 (PTPN22) gene, PTPN22 R620W, constitutes the strongest non-HLA genetic risk factor for the development of type 1 diabetes (T1D). A number of studies using mouse models have addressed how PTPN22 predisposes to T1D. PTPN22 downmodulation, overexpression or expression of the variant gene in genetically manipulated mice has generated controversial results. These discrepancies probably derive from the fact that PTPN22 has differential effects on innate and adaptive immune responses...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751954/obesity-metabolic-syndrome-and-diabetic-retinopathy-beyond-hyperglycemia
#9
REVIEW
Osinakachukwu Mbata, Nada Fawzy Abo El-Magd, Azza Bahram El-Remessy
Diabetic retinopathy (DR) is the most feared ocular manifestation of diabetes. DR is characterized by progressive retinal damage that may eventually result in blindness. Clinically, this blindness is caused by progressive damage to the retinal microvasculature, which leads to ischemia, retinal swelling, and neovascularization. Retinopathy is associated with both type 1 and type 2 diabetes, with DR being the leading cause of new onset blindness in United States adults. Despite this strong association with diabetes, it must be noted that the development of retinopathy lesions is multifactorial and may occur in individuals without an established history of diabetes...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751953/pcsk9-and-carbohydrate-metabolism-a-double-edged-sword
#10
EDITORIAL
Theodosios D Filippatos, Sebastian Filippas-Ntekouan, Eleni Pappa, Thalia Panagiotopoulou, Vasilios Tsimihodimos, Moses S Elisaf
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a paramount role in the degradation of low-density lipoprotein (LDL) receptors (LDLR) on the hepatic cells surface and subsequently affects LDL particles catabolism and LDL cholesterol (LDL-c) levels. The anti-PCSK9 monoclonal antibodies lead to substantial decrease of LDL-c concentration. PCSK9 (which is also expressed in pancreatic delta-cells) can decrease LDLR and subsequently decrease cholesterol accumulation in pancreatic beta-cells, which impairs glucose metabolism and reduces insulin secretion...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572883/impact-of-creatinine-methodology-on-glomerular-filtration-rate-estimation-in-diabetes
#11
Marijana Vučić Lovrenčić, Vanja Radišić Biljak, Kristina Blaslov, Sandra Božičević, Lea Smirčić Duvnjak
AIM: To evaluate the influence of creatinine methodology on the performance of chronic kidney disease (CKD)-Epidemiology Collaboration Group-calculated estimated glomerular filtration rate (CKD-EPI-eGFR) for CKD diagnosis/staging in a large cohort of diabetic patients. METHODS: Fasting blood samples were taken from diabetic patients attending our clinic for their regular annual examination, including laboratory measurement of serum creatinine and eGFR. RESULTS: Our results indicated an overall excellent agreement in CKD staging (kappa = 0...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572882/nonsurgical-periodontal-therapy-improves-glycosylated-hemoglobin-levels-in-pre-diabetic-patients-with-chronic-periodontitis
#12
Rosamma Joseph, Meera Sasikumar, Jerry Mammen, M G Joseraj, Chandni Radhakrishnan
AIM: To evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis (CHP). METHODS: Sixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters (plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin (HbA1c), fasting lipid profile, and fasting blood glucose]...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572881/association-between-dairy-intake-lipids-and-vascular-structure-and-function-in-diabetes
#13
Kristina S Petersen, Jennifer B Keogh, Natalie Lister, Jacquelyn M Weir, Peter J Meikle, Peter M Clifton
AIM: To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and function. METHODS: A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes (n = 108)...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572880/effect-of-medicinal-mushrooms-on-blood-cells-under-conditions-of-diabetes-mellitus
#14
REVIEW
Taras Vitak, Borys Yurkiv, Solomon Wasser, Eviatar Nevo, Natalia Sybirna
Diabetes mellitus (DM) is the third most common non-infectious disease leading to early disability and high mortality. Moreover, the number of patients is growing every year. The main symptom of DM is hyperglycemia. Increased levels of blood glucose activate polyol, hexosamine, and protein kinase metabolic pathways cause the intensification of non-enzymatic glycosylation and nitration of macromolecules. This, in turn, leads to the development of oxidative and nitrative stresses and secondary complications, such as different kinds of micro- and macroangiopathies...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572879/effects-of-glycaemic-management-on-diabetic-kidney-disease
#15
REVIEW
Richard J MacIsaac, George Jerums, Elif I Ekinci
Hyperglycaemia contributes to the onset and progression of diabetic kidney disease (DKD). Observational studies have not consistently demonstrated a glucose threshold, in terms of HbA1c levels, for the onset of DKD. Tight glucose control has clearly been shown to reduce the incidence of micro- or macroalbuminuria. However, evidence is now also emerging to suggest that intensive glucose control can slow glomerular filtration rate loss and possibly progression to end stage kidney disease. Achieving tight glucose control needs to be balanced against the increasing appreciation that glucose targets for the prevention of diabetes related complications need be individualised for each patient...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465793/kmap-o-framework-for-care-management-research-of-patients-with-type-2-diabetes
#16
Thomas T H Wan, Amanda Terry, Bobbie McKee, Waleed Kattan
AIM: To review impacts of interventions involving self-management education, health coaching, and motivational interviewing for type 2 diabetes. METHODS: A thorough review of the scientific literature on diabetes care and management was executed by a research team. RESULTS: This article summarizes important findings in regard to the validity of developing a comprehensive behavioral system as a framework for empirical investigation. The behavioral system framework consists of patients' knowledge (K), motivation (M), attitude (A), and practice (P) as predictor variables for diabetes care outcomes (O)...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465792/effects-of-intermittent-fasting-on-health-markers-in-those-with-type-2-diabetes-a-pilot-study
#17
Terra G Arnason, Matthew W Bowen, Kerry D Mansell
AIM: To determine the short-term biochemical effects and clinical tolerability of intermittent fasting (IF) in adults with type 2 diabetes mellitus (T2DM). METHODS: We describe a three-phase observational study (baseline 2 wk, intervention 2 wk, follow-up 2 wk) designed to determine the clinical, biochemical, and tolerability of IF in community-dwelling volunteer adults with T2DM. Biochemical, anthropometric, and physical activity measurements (using the Yale Physical Activity Survey) were taken at the end of each phase...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465791/insulin-mimetic-compound-hexaquis-benzylammonium-decavanadate-is-antilipolytic-in-human-fat-cells
#18
Christian Carpéné, Silvia Garcia-Vicente, Marta Serrano, Luc Marti, Chloé Belles, Miriam Royo, Jean Galitzky, Antonio Zorzano, Xavier Testar
AIM: To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate (B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids (FFA) and glucose circulating levels. METHODS: Adipose tissue (AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents (insulin, benzylamine, vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465790/osteomyelitis-in-diabetic-foot-a-comprehensive-overview
#19
REVIEW
Laura Giurato, Marco Meloni, Valentina Izzo, Luigi Uccioli
Foot infection is a well recognized risk factor for major amputation in diabetic patients. The osteomyelitis is one of the most common expression of diabetic foot infection, being present approximately in present in 10%-15% of moderate and in 50% of severe infectious process. An early and accurate diagnosis is required to ensure a targeted treatment and reduce the risk of major amputation. The aim of this review is to report a complete overview about the management of diabetic foot osteomyelitis. Epidemiology, clinical aspects, diagnosis and treatment are widely described according to scientific reccomendations and our experience...
April 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28465789/syndecan-1-coating-of-interleukin-17-producing-natural-killer-t-cells-provides-a-specific-method-for-their-visualization-and-analysis
#20
REVIEW
Anil Kumar Jaiswal, Mohanraj Sadasivam, Abdel Rahim A Hamad
Natural killer T cells (NKT cells) are innate-like T cells that acquire effector functions while developing in the thymus, polarize into three distinct functional subsets viz. NKT1, NKT2 and NKT17 cells that produce interferon (IFN)-γ, interleukin (IL)-4 and IL-17, respectively. However, there has been no unique surface markers that define each subsets, forcing investigators to use intracellular staining of transcription factors and cytokines in combination of surface markers to distinguish among these subsets...
April 15, 2017: World Journal of Diabetes
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