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World Journal of Diabetes

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https://www.readbyqxmd.com/read/28989570/eye-and-foot-checks-in-patients-with-diabetes-on-haemodialysis-are-they-done-and-who-does-them
#1
Nadira Bibi Mothojakan, Shazia Hussain, Kieran McCafferty, Mohammed Magdi Yaqoob, Tahseen Ahmad Chowdhury
AIM: To determine if retinal and foot checks are carried out on patients with diabetes receiving haemodialysis. METHODS: Eighty-four patients with diabetes receiving haemodialysis were asked if they recalled having eye and foot screening in the last year, and if so, by whom was the check done. RESULTS: Seventy-seven (91.7%) patients recalled having an eye check in the preceding 12 mo. Of these, 52 (67.5%) did so in an ophthalmology clinic, 17 (22%) in retinal screening, three (3...
September 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28989569/clinical-profile-of-diabetes-at-diagnosis-among-children-and-adolescents-at-an-endocrine-clinic-in-ghana
#2
Emmanuel Ameyaw, Serwah B Asafo-Agyei, Sumithira Thavapalan, Angela C Middlehurst, Graham D Ogle
AIM: To determine the clinical features of diabetes in children and adolescents in Ghana. METHODS: Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016. RESULTS: One hundred and six subjects presented with diabetes. Ninety (84.9%) were diagnosed by clinical features and family history as type 1, and 16 (15...
September 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28989568/expression-of-matrix-metalloproteinase-11-is-increased-under-conditions-of-insulin-resistance
#3
Biagio Arcidiacono, Eusebio Chiefari, Anna Elisa Laria, Sebastiano Messineo, Francesco Luciano Bilotta, Domenico Britti, Daniela Patrizia Foti, Anna Foryst-Ludwig, Ulrich Kintscher, Antonio Brunetti
AIM: To investigate matrix metalloproteinase-11 (MMP-11) expression in adipose tissue dysfunction, using in vitro and in vivo models of insulin resistance. METHODS: Culture of mouse 3T3-L1 preadipocytes were induced to differentiation into mature 3T3-L1 adipocytes. Cellular insulin resistance was induced by treating differentiated cultured adipocytes with hypoxia and/or tumor necrosis factor (TNF)-α, and transcriptional changes were analyzed in each condition thereafter...
September 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28861179/impact-on-dietary-intake-of-a-self-directed-gender-tailored-diabetes-prevention-program-in-men
#4
Megan E Rollo, Elroy J Aguiar, Kirrilly M Pursey, Philip J Morgan, Ronald C Plotnikoff, Myles D Young, Clare E Collins, Robin Callister
AIM: To investigate changes in dietary intake following a 6-mo randomised controlled trial of the self-directed, gender-tailored type 2 diabetes mellitus (T2DM) Prevention Using LifeStyle Education (PULSE) program in men. METHODS: Men aged 18-65 years, with a body mass index (BMI) 25-40 kg/m(2), and at high risk for developing T2DM were recruited from the Hunter Region of New South Wales, Australia. Eligible participants were randomised into one of two groups: (1) waitlist control; or (2) PULSE intervention...
August 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28861178/clinico-epidemiological-factors-of-health-related-quality-of-life-among-people-with-type-2-diabetes
#5
Azra Mamaghanian, Seyed Morteza Shamshirgaran, Nayyereh Aiminisani, Akbar Aliasgarzadeh
AIM: To investigate the quality of life (QOL) and its clinical and epidemiological correlates among people with type 2 diabetes. METHODS: This cross-sectional study was conducted in Tabriz, Northwest of Iran, including a total of 394 people with type 2 diabetes using convenient sampling method from November 2014 to March 2015. General information including demographic, socioeconomic status and lifestyle factors were collected by trained interviewers. Clinical information was retrieved from clinic's record and QOL was assessed using the 26-item WHOQOL-BRIFE questionnaire...
August 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28861177/age-dependent-changes-in-the-association-between-sleep-duration-and-impaired-glucose-metabolism
#6
Kei Nakajima, Kaname Suwa, Kenji Toyama
AIM: To investigate whether the association between sleep duration and impaired glucose metabolism varies among younger and older populations. METHODS: We reviewed data of self-reported habitual sleep duration per night, HbA1c levels, and clinically relevant factors in a cross-sectional checkup database of 75472 Japanese from the general population aged 20-79 years (51695 men and 23777 women). Associations of prediabetes (HbA1c ≥ 5.7% and/or diabetic pharmacotherapy) or diabetes (HbA1c ≥ 6...
August 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28861176/prevalence-of-obesity-and-diabetes-in-patients-with-schizophrenia
#7
Aniyizhai Annamalai, Urska Kosir, Cenk Tek
AIM: To compare the prevalence of diabetes in patients with schizophrenia treated at a community mental health center with controls in the same metropolitan area and to examine the effect of antipsychotic exposure on diabetes prevalence in schizophrenia patients. METHODS: The study was a comprehensive chart review of psychiatric notes of patients with schizophrenia and schizoaffective disorder treated at a psychosis program in a community mental health center. Data collected included psychiatric diagnoses, diabetes mellitus diagnosis, medications, allergies, primary care status, height, weight, body mass index (BMI), substance use and mental status exam...
August 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751962/autologous-bone-marrow-derived-stem-cell-therapy-in-patients-with-type-2-diabetes-mellitus-defining-adequate-administration-methods
#8
Vikas Sood, Anil Bhansali, Bhagwant Rai Mittal, Baljinder Singh, Neelam Marwaha, Ashish Jain, Niranjan Khandelwal
AIM: To carry out randomized trial for evaluating effects of autologous bone marrow derived stem cell therapy (ABMSCT) through different routes. METHODS: Bone marrow aspirate was taken from the iliac crest of patients. Bone marrow mononuclear cells were separated and purified using centrifugation. These cells were then infused in a total of 21 patients comprising three groups of 7 patients each. Cells were infused into the superior pancreaticoduodenal artery (Group I), splenic artery (Group II) and through the peripheral intravenous route (Group III)...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751961/effect-of-bariatric-surgery-on-adiposity-and-metabolic-profiles-a-prospective-cohort-study-in-middle-eastern-patients
#9
Mohsen Mazidi, Peyman Rezaie, Ali Jangjoo, Alireza Tavassoli, Mohammad Taghi Rajabi, Andre Pascal Kengne, Mohsen Nematy
AIM: To investigate changes in adiposity and cardio-metabolic risk profile following Roux-en-Y gastric bypass in patients of Middle Eastern ethnicity with severe obesity. METHODS: This prospective cohort study involved 92 patients who met the indications of bariatric surgery. Post-procedure markers of obesity and cardiometabolic profile were monitored regularly for a year. RESULTS: Mean body mass index decreased by 29.5% from 41.9 to 29.5 kg/m(2) between baseline and 12-mo follow-up, while mean fat mass decreased by 45...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751960/are-body-mass-index-and-waist-circumference-significant-predictors-of-diabetes-and-prediabetes-risk-results-from-a-population-based-cohort-study
#10
Fahimeh Haghighatdoost, Masoud Amini, Awat Feizi, Bijan Iraj
AIM: To determine the predictive role of body mass index (BMI) and waist circumference (WC) for diabetes and prediabetes risk in future in total sample as well as in men and women separately. METHODS: In a population based cohort study, 1765 with mean ± SD age: 42.32 ± 6.18 healthy participants were followed up from 2003 till 2013 (n = 960). Anthropometric and biochemical measures of participants were evaluated regularly during the follow up period. BMI and WC measures at baseline and diabetes and prediabetes status of participants at 2013 were determined...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751959/quality-of-sleep-and-its-determinants-among-people-with-type-2-diabetes-mellitus-in-northwest-of-iran
#11
Seyed Morteza Shamshirgaran, Jafar Ataei, Ayyoub Malek, Manochehr Iranparvar-Alamdari, Nayyereh Aminisani
AIM: To examine sleep quality and its determinants among people with type 2 diabetes mellitus (T2DM). METHODS: This is a cross-sectional study conducted among diabetic patients referring to Ardabil diabetes clinic in Northwest of Iran. Information on sleep quality was collected using Pittsburg Sleep Quality Index (PSQI). A questionnaire was used to collect data on sociodemographic lifestyle factors and psychological distress. This questionnaire was completed through an interview, and clinical information was extracted from patient's record...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751958/type-2-diabetes-in-a-senegalese-rural-area
#12
Priscilla Duboz, Gilles Boëtsch, Lamine Gueye, Enguerran Macia
AIM: To estimate the prevalence of diabetes in the rural population of Tessekere (Senegal) and investigate associated risk factors. METHODS: Data from a 2015 survey of 500 individuals age 20 and over representative of the population of the municipality of Tessekere were used. Sociodemographic characteristics, health related variables, capillary whole blood glucose, and weight and height measurements of individuals were collected during face-to-face interviews. Statistical analyses used were bivariate tests and binary logistic regressions...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751957/vitamin-d-levels-in-subjects-with-or-without-chronic-kidney-disease-among-veterans-with-diabetes-in-north-east-united-states
#13
Subhashini Yaturu, Barbara Youngberg, Sonya Zdunek
AIM: To evaluate the prevalence of vitamin D deficiency and its relation to diabetes and kidney disease in Veterans residing in the North East United States (VISN 2). METHODS: In this retrospective study, we used data from the computerized patient record system at Stratton Veterans Administration Medical Center at Albany, NY (VHA) for those patients who had 25-hydroxyvitamin D levels and 1,25 (OH) vitamin D levels measured between 2007 and 2010. We collected demographic information including age, sex, body mass index and race; clinical data including diabetes, hypertension and CAD; and laboratory data including calcium, creatinine and parathyroid hormone (PTH) (intact)...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751956/saponins-as-adipokines-modulator-a-possible-therapeutic-intervention-for-type-2-diabetes
#14
REVIEW
Olusola Olalekan Elekofehinti, Oluwamodupe Cecilia Ejelonu, Jean Paul Kamdem, Oluwaseun Benedicta Akinlosotu, Isaac Gbadura Adanlawo
Development of type 2 diabetes has been linked to β-cell failure coupled with insulin resistance and obesity. Adipose tissue, known as the fat store, secretes a number of hormones and proteins collectively termed adipokines some of which regulate insulin sensitivity. Dysregulation in the secretion of adipokines has been linked to insulin resistance and type 2 diabetes. In this review, we summarized evidence of the role of adipokines with focus on leptin, adiponectin, adipsin, visfatin and apelin in the pathogenesis of type 2 diabetes and discussed the potential of saponins to modify the ill-regulated adipokines secretions, which could promote the use of this class of phytochemicals as potential antidiabetics agents...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751955/ptpn22-and-islet-specific-autoimmunity-what-have-the-mouse-models-taught-us
#15
REVIEW
Giuseppe Galvani, Georgia Fousteri
An allelic variant of the protein tyrosin phosphatase non-receptor 22 (PTPN22) gene, PTPN22 R620W, constitutes the strongest non-HLA genetic risk factor for the development of type 1 diabetes (T1D). A number of studies using mouse models have addressed how PTPN22 predisposes to T1D. PTPN22 downmodulation, overexpression or expression of the variant gene in genetically manipulated mice has generated controversial results. These discrepancies probably derive from the fact that PTPN22 has differential effects on innate and adaptive immune responses...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751954/obesity-metabolic-syndrome-and-diabetic-retinopathy-beyond-hyperglycemia
#16
REVIEW
Osinakachukwu Mbata, Nada Fawzy Abo El-Magd, Azza Bahram El-Remessy
Diabetic retinopathy (DR) is the most feared ocular manifestation of diabetes. DR is characterized by progressive retinal damage that may eventually result in blindness. Clinically, this blindness is caused by progressive damage to the retinal microvasculature, which leads to ischemia, retinal swelling, and neovascularization. Retinopathy is associated with both type 1 and type 2 diabetes, with DR being the leading cause of new onset blindness in United States adults. Despite this strong association with diabetes, it must be noted that the development of retinopathy lesions is multifactorial and may occur in individuals without an established history of diabetes...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28751953/pcsk9-and-carbohydrate-metabolism-a-double-edged-sword
#17
EDITORIAL
Theodosios D Filippatos, Sebastian Filippas-Ntekouan, Eleni Pappa, Thalia Panagiotopoulou, Vasilios Tsimihodimos, Moses S Elisaf
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a paramount role in the degradation of low-density lipoprotein (LDL) receptors (LDLR) on the hepatic cells surface and subsequently affects LDL particles catabolism and LDL cholesterol (LDL-c) levels. The anti-PCSK9 monoclonal antibodies lead to substantial decrease of LDL-c concentration. PCSK9 (which is also expressed in pancreatic delta-cells) can decrease LDLR and subsequently decrease cholesterol accumulation in pancreatic beta-cells, which impairs glucose metabolism and reduces insulin secretion...
July 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572883/impact-of-creatinine-methodology-on-glomerular-filtration-rate-estimation-in-diabetes
#18
Marijana Vučić Lovrenčić, Vanja Radišić Biljak, Kristina Blaslov, Sandra Božičević, Lea Smirčić Duvnjak
AIM: To evaluate the influence of creatinine methodology on the performance of chronic kidney disease (CKD)-Epidemiology Collaboration Group-calculated estimated glomerular filtration rate (CKD-EPI-eGFR) for CKD diagnosis/staging in a large cohort of diabetic patients. METHODS: Fasting blood samples were taken from diabetic patients attending our clinic for their regular annual examination, including laboratory measurement of serum creatinine and eGFR. RESULTS: Our results indicated an overall excellent agreement in CKD staging (kappa = 0...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572882/nonsurgical-periodontal-therapy-improves-glycosylated-hemoglobin-levels-in-pre-diabetic-patients-with-chronic-periodontitis
#19
Rosamma Joseph, Meera Sasikumar, Jerry Mammen, M G Joseraj, Chandni Radhakrishnan
AIM: To evaluate the effect of nonsurgical periodontal therapy on glycosylated haemoglobin levels in pre-diabetic patients with chronic periodontitis (CHP). METHODS: Sixty pre-diabetic patients with CHP were selected and equally allocated to case and control group. All subjects were evaluated at base line for periodontal parameters (plaque index, oral hygiene index, modified gingival index, probing pocket depth, clinical attachment level) and systemic parameters [glycosylated hemoglobin (HbA1c), fasting lipid profile, and fasting blood glucose]...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28572881/association-between-dairy-intake-lipids-and-vascular-structure-and-function-in-diabetes
#20
Kristina S Petersen, Jennifer B Keogh, Natalie Lister, Jacquelyn M Weir, Peter J Meikle, Peter M Clifton
AIM: To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and function. METHODS: A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes (n = 108)...
May 15, 2017: World Journal of Diabetes
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