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Journal of Advanced Research

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https://www.readbyqxmd.com/read/28879059/pulmonary-hypertension-and-cardiac-hypertrophy-in-children-recipients-of-orthotopic-living-related-liver-transplantation
#1
Magd A Kotb, Inas Abd El Satar, Ahmed M Badr, Nancy H Anis, Hoda Abd El Rahman Ismail, Alaa F Hamza, Hesham M Abdelkader
Surgical stress, liberation of cytokines associated with re-perfusion injury, and long standing use of immune suppressive medications in children recipients of orthotopic living related liver transplantation (OLRLT) pose cardiovascular risk. Reported cardiovascular adverse effects vary from left ventricular wall thickening, hypertrophic cardiomyopathy to resting ECG abnormalities, asymptomatic ST depression following increased heart rate and ventricular arrhythmias. Twenty-five consecutive children recipients of OLRLT were assessed by conventional 2-D, M-mode echocardiography and Doppler...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28861282/convective-thermal-and-concentration-transfer-effects-in-hydromagnetic-peristaltic-transport-with-ohmic-heating
#2
F M Abbasi, S A Shehzad
The primary theme of this communication is to employ convective condition of mass transfer in the theory of peristalsis. The magnetohydrodynamic (MHD) peristaltic transport of viscous liquid in an asymmetric channel was considered for this purpose. Effects of Ohmic heating and Soret and Dufour are presented. The governing mathematical model was expressed in terms of closed form solution expressions. Attention has been focused to the analysis of temperature and concentration distributions. The graphical results are presented to visualize the impact of sundry quantities on temperature and concentration...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28861281/comparing-intensities-and-modalities-within-the-sensory-attenuation-paradigm-preliminary-evidence
#3
Dalila Burin, Alvise Battaglini, Lorenzo Pia, Giusy Falvo, Mattia Palombella, Adriana Salatino
It is well-documented that the intensity of a self-generated somatosensory stimulus is perceived to be attenuated in respect to an identical stimulus generated by others. At present, it is not clear whether such a phenomenon, known as somatosensory attenuation, is based not only on feedforward motor signals but also on re-afferences towards the body. To answer this question, in the present pilot investigation on twelve healthy subjects, three types of stimulations (sensory non-nociceptive electrical - ES, nociceptive electrical - NES, and vibrotactile - VTS) and intensities (1 = sensory threshold ∗ 2...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28840041/a-comparison-between-different-finite-elements-for-elastic-and-aero-elastic-analyses
#4
Mohamed Mahran, Adel ELsabbagh, Hani Negm
In the present paper, a comparison between five different shell finite elements, including the Linear Triangular Element, Linear Quadrilateral Element, Linear Quadrilateral Element based on deformation modes, 8-node Quadrilateral Element, and 9-Node Quadrilateral Element was presented. The shape functions and the element equations related to each element were presented through a detailed mathematical formulation. Additionally, the Jacobian matrix for the second order derivatives was simplified and used to derive each element's strain-displacement matrix in bending...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28831308/effective-bioremediation-of-a-petroleum-polluted-saline-soil-by-a-surfactant-producing-pseudomonas-aeruginosa-consortium
#5
Ali Ebadi, Nayer Azam Khoshkholgh Sima, Mohsen Olamaee, Maryam Hashemi, Reza Ghorbani Nasrabadi
Bacteria able to produce biosurfactants can use petroleum-based hydrocarbons as a carbon source. Herein, four biosurfactant-producing Pseudomonas aeruginosa strains, isolated from oil-contaminated saline soil, were combined to form a bacterial consortium. The inoculation of the consortium to contaminated soil alleviated the adverse effects of salinity on biodegradation and increased the rate of degradation of petroleum hydrocarbon approximately 30% compared to the rate achieved in non-treated soil. In saline condition, treatment of polluted soil with the consortium led to a significant boost in the activity of dehydrogenase (approximately 2-fold)...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28819569/a-study-on-il8rb-gene-polymorphism-as-a-potential-immuno-compromised-adherent-in-exaggeration-of-parenteral-and-mammo-crine-oxidative-stress-during-mastitis-in-buffalo
#6
S M El Nahas, A H El Kasas, A A Abou Mossallem, M I Abdelhamid, Mohamad Warda
The genetic markers in inflammatory responses during mastitis afford a reasonable way for improving milk production in the Egyptian buffalo breed. Among them is the interleukin 8 Receptor Gene (IL8RB) (CXCR2); a chemokine receptor gene augments the neutrophil migration during infection. To understand its role better during mastitis in Egyptian buffalos, twenty-five dairy animals representing the normal, sub-clinically, clinically and chronically affected buffalos were randomly selected from different districts...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28808589/anti-angiogenic-agents-for-the-treatment-of-solid-tumors-potential-pathways-therapy-and-current-strategies-a-review
#7
REVIEW
Ahmed M Al-Abd, Abdulmohsin J Alamoudi, Ashraf B Abdel-Naim, Thikryat A Neamatallah, Osama M Ashour
Recent strategies for the treatment of cancer, other than just tumor cell killing have been under intensive development, such as anti-angiogenic therapeutic approach. Angiogenesis inhibition is an important strategy for the treatment of solid tumors, which basically depends on cutting off the blood supply to tumor micro-regions, resulting in pan-hypoxia and pan-necrosis within solid tumor tissues. The differential activation of angiogenesis between normal and tumor tissues makes this process an attractive strategic target for anti-tumor drug discovery...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28794904/qbd-based-approach-for-optimization-of-tenofovir-disoproxil-fumarate-loaded-liquid-crystal-precursor-with-improved-permeability
#8
Sharvil Patil, Chandrashekhar Kadam, Varsha Pokharkar
BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was used for preparation of TDF loaded liquid crystal precursors (LCP) consisting of GMO/Pluronic F127 and lactose monohydrate with an ability to in situ transform into stable cubic phases upon hydration...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28794903/a-novel-plant-based-sea-water-culture-media-for-in-vitro-cultivation-and-in-situ-recovery-of-the-halophyte-microbiome
#9
Mohamed Y Saleh, Mohamed S Sarhan, Elhussein F Mourad, Mervat A Hamza, Mohamed T Abbas, Amal A Othman, Hanan H Youssef, Ahmed T Morsi, Gehan H Youssef, Mahmoud El-Tahan, Wafaa A Amer, Mohamed Fayez, Silke Ruppel, Nabil A Hegazi
The plant-based-sea water culture medium is introduced to in vitro cultivation and in situ recovery of the microbiome of halophytes. The ice plant (Mesembryanthemum crystallinum) was used, in the form of juice and/or dehydrated plant powder packed in teabags, to supplement the natural sea water. The resulting culture medium enjoys the combinations of plant materials as rich source of nutrients and sea water exercising the required salt stress. As such without any supplements, the culture medium was sufficient and efficient to support very good in vitro growth of halotolerant bacteria...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28794902/generic-distributed-framework-for-cloud-services-marketplace-based-on-unified-ontology
#10
Samer Hasan, V Valli Kumari
Cloud computing is a pattern for delivering ubiquitous and on demand computing resources based on pay-as-you-use financial model. Typically, cloud providers advertise cloud service descriptions in various formats on the Internet. On the other hand, cloud consumers use available search engines (Google and Yahoo) to explore cloud service descriptions and find the adequate service. Unfortunately, general purpose search engines are not designed to provide a small and complete set of results, which makes the process a big challenge...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28765792/economical-synthesis-of-silver-nanoparticles-using-leaf-extract-of-acalypha-hispida-and-its-application-in-the-detection-of-mn-ii-ions
#11
R Sithara, P Selvakumar, C Arun, S Anandan, P Sivashanmugam
This study was focused on the synthesis of silver nanoparticles using Acalypha hispida leaf extract and the characterization of the particles using UV-Vis spectroscopy, XRD, FT-IR, and TEM. The results showed the formation of silver nanoparticles, crystalline in nature, with an average size of 20-50 nm. The leaf extract components were analyzed with GC-MS and exhibited a high content of Phytol (40.52%), n-Hexadecanoic acid (9.67%), 1,2,3-Benzenetriol (7.04%), α-d-Mannofuranoside methyl (6.22%), and d-Allose (4...
November 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748122/asymptomatic-hyperuricemia-and-chronic-kidney-disease-narrative-review-of-a-treatment-controversial
#12
REVIEW
Theodoros Eleftheriadis, Spyridon Golphinopoulos, Georgios Pissas, Ioannis Stefanidis
Today there is plausible evidence both on experimental and epidemiological basis, that hyperuricemia represents a risk factor for the development and progression of chronic kidney disease (CKD). Nevertheless, the role of serum uric acid lowering treatment in CKD is still a matter of serious controversy. Review of randomised controlled trials, suggests that there may be an improvement of renal function with allopurinol treatment in CKD stage 3-5. However, these studies have included a relatively limited number of participants and provide insufficient information on adverse events and on the incidence of the end stage renal disease...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748121/treatment-of-asymptomatic-hyperuricemia-in-chronic-kidney-disease-a-new-target-in-an-old-enemy-a-review
#13
REVIEW
Maria Erika G Ramirez, Joanne M Bargman
Asymptomatic hyperuricemia is increasing in prevalence. There is a growing body of literature suggesting that uric acid has deleterious effects on vascular health and renal histological integrity. Several trials, reviewed herein, suggest that lowering the serum uric acid level is associated with a slowing in the rate of renal deterioration in those with chronic kidney disease. Given that there is little available in the general armamentarium to slow the rate of kidney deterioration, strong consideration could be given to the administration of agents or lifestyle changes that decrease uric acid production in hyperuricemic patients with deteriorating kidney function...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748120/the-grey-zone-of-hyperuricemia-in-chronic-kidney-disease
#14
EDITORIAL
Periklis Dousdampanis
No abstract text is available yet for this article.
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748119/uric-acid-in-the-pathogenesis-of-metabolic-renal-and-cardiovascular-diseases-a-review
#15
REVIEW
Usama A A Sharaf El Din, Mona M Salem, Dina O Abdulazim
The association between uric acid (UA) on one side and systemic hypertension (Htn), dyslipidemia, glucose intolerance, overweight, fatty liver, renal disease and cardiovascular disease (CVD) on the other side is well recognized. However, the causal relationship between UA and these different clinical problems is still debatable. The recent years have witnessed hundreds of experimental and clinical trials that favored the opinion that UA is a probable player in the pathogenesis of these disease entities. These studies disclosed the strong association between hyperuricemia and metabolic syndrome (MS), obesity, Htn, type 2 diabetes mellitus (DM), non-alcoholic fatty liver disease, hypertriglyceridemia, acute kidney injury, chronic kidney disease (CKD), coronary heart disease (CHD), heart failure and increased mortality among cardiac and CKD patients...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748118/serum-uric-acid-and-acute-kidney-injury-a-mini-review
#16
REVIEW
Kai Hahn, Mehmet Kanbay, Miguel A Lanaspa, Richard J Johnson, A Ahsan Ejaz
Acute kidney injury causes great morbidity and mortality in both the community and hospital settings. Understanding the etiological factors and the pathophysiological principles resulting in acute kidney injury is essential in prompting appropriate therapies. Recently hyperuricemia has been recognized as a potentially modifiable risk factor for acute kidney injury, including that associated with cardiovascular surgery, radiocontrast administration, rhabdomyolysis, and associated with heat stress. This review discussed the evidence that repeated episodes of acute kidney injury from heat stress and dehydration may also underlie the pathogenesis of the chronic kidney disease epidemic that is occurring in Central America (Mesoamerican nephropathy)...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748117/epidemiology-pathophysiology-and-management-of-uric-acid-urolithiasis-a-narrative-review
#17
REVIEW
A Abou-Elela
An in-depth comprehension of the epidemiology as well as pathophysiology of uric acid urolithiasis is important for the identification, treatment, and prophylaxis of calculi in these patients. Persistently low urinary pH, hyperuricosuria, and low urinary volume are the most important factors in pathogenesis of uric acid urolithiasis. Other various causes of calculus formation comprises of chronic diarrhea, renal hyperuricosuria, insulin resistance, primary gout, extra purine in the diet, neoplastic syndromes, and congenital hyperuricemia...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748116/gout-an-old-disease-in-new-perspective-a-review
#18
REVIEW
Gaafar Ragab, Mohsen Elshahaly, Thomas Bardin
Gout is a picturesque presentation of uric acid disturbance. It is the most well understood and described type of arthritis. Its epidemiology is studied. New insights into the pathophysiology of hyperuricemia and gouty arthritis; acute and chronic allow for an even better understanding of the disease. The role of genetic predisposition is becoming more evident. The clinical picture of gout is divided into asymptomatic hyperuricemia, acute gouty arthritis, intercritical period, and chronic tophaceous gout. Diagnosis is based on laboratory and radiological features...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748115/physiological-functions-and-pathogenic-potential-of-uric-acid-a-review
#19
REVIEW
Rashika El Ridi, Hatem Tallima
Uric acid is synthesized mainly in the liver, intestines and the vascular endothelium as the end product of an exogenous pool of purines, and endogenously from damaged, dying and dead cells, whereby nucleic acids, adenine and guanine, are degraded into uric acid. Mentioning uric acid generates dread because it is the established etiological agent of the severe, acute and chronic inflammatory arthritis, gout and is implicated in the initiation and progress of the metabolic syndrome. Yet, uric acid is the predominant anti-oxidant molecule in plasma and is necessary and sufficient for induction of type 2 immune responses...
September 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28748114/uric-acid-in-plants-and-microorganisms-biological-applications-and-genetics-a-review
#20
REVIEW
Rehab M Hafez, Tahany M Abdel-Rahman, Rasha M Naguib
Uric acid increased accumulation and/or reduced excretion in human bodies is closely related to pathogenesis of gout and hyperuricemia. It is highly affected by the high intake of food rich in purine. Uric acid is present in both higher plants and microorganisms with species dependent concentration. Urate-degrading enzymes are found both in plants and microorganisms but the mechanisms by which plant degrade uric acid was found to be different among them. Higher plants produce various metabolites which could inhibit xanthine oxidase and xanthine oxidoreductase, so prohibit the oxidation of hypoxanthine to xanthine then to uric acid in the purine metabolism...
September 2017: Journal of Advanced Research
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