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Journal of Advanced Research

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https://www.readbyqxmd.com/read/28721301/synthesis-and-characterization-of-n-mannich-based-prodrugs-of-ciprofloxacin-and-norfloxacin-in-vitro-anthelmintic-and-cytotoxic-evaluation
#1
Mona Piplani, Harish Rajak, Prabodh Chander Sharma
Prodrugs, the inert derivatives of existing drugs have successfully contributed to the modification of their physicochemical properties. The improved antimicrobial potential due to enhanced lipophilicity of some of the synthesized prodrugs of antibacterial agents by various schemes has already been reported. In the current study, synthesis, characterization, and biological evaluation of some more lipid based prodrugs/compounds of ciprofloxacin and norfloxacin has been carried out. The synthesized prodrugs/compounds have been screened for anthelmintic activity using Indian earthworms and cytotoxic activity against human lung cancer cell lines A-549 employing sulforhodamine B (SRB) assay method...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28721300/extracellular-matrix-alterations-in-the-peyronie-s-disease
#2
Marcelo Silva Watanabe, Thérèse Rachel Theodoro, Natália Lima Coelho, Aline Mendes, Monica Luzia Pereira Leonel, Ana Maria Mader, Helena Bonciani Nader, Sidney Glina, Maria Aparecida Silva Pinhal
Peyronie's disease is characterized by fibrous plaque formation of the tunica albuginea, causing penile deformity and fertility problems. The aim of the present study was to investigate alterations in the extracellular matrix in Peyronie's disease. The study used tissues collected by surgical procedure from individuals that presented a well-established disease, while control samples were obtained by biopsies of fresh cadavers. Immunohistochemistry analysis followed by digital quantification was performed to evaluate TGF-β, heparanases and metalloproteinases (MMPs)...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28721299/development-of-ionophore-based-nanosphere-emulsion-incorporating-ion-exchanger-for-complexometric-titration-of-thiocyanate-anion
#3
Fatehy M Abdel-Haleem, Mahmoud S Rizk
Ionophore-based ion-exchange nanosphere emulsion was prepared and tested for the determination of thiocyanate. The emulsified nanosphere contained the cationic additive tridodecylmethyl ammonium chloride (TDMAC), the plasticizer, and the ionophore Mn(III)-salophen or Mn(III)-salen. This emulsion was used as titrating agent for thiocyanate complexation with ionophores, which could be transduced using an ion-selective electrode (ISE) as an indicator electrode for the end point detection. The method showed no need for pH control and reliable selectivity, as thiocyanate could be determined in presence of other interfering ions with high accuracy...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28721298/hydrocortisone-relieves-the-immediate-post-operative-scrotal-edema-after-inguinal-varicocelectomy-a-prospective-clinical-trial
#4
Samir Elhanbly, Tamer Youssef, Ayman Elkholy, Mamdouh Abdel-Gawad, Taymour Mostafa
This study aimed to assess the effect of a single IM injection of hydrocortisone succinate in relieving the immediate post-varicocelectomy scrotal edema. In all, 117 patients with grades II and III varicocele who developed post-varicocelectomy scrotal edema were randomly classified into group A (n = 59) that received a single IM hydrocortisone sodium succinate injection plus ordinary post-operative treatment and Group B (n = 58), which received the post-operative treatment alone. All patients were followed up to assess; changes in scrotal edema, the day of return to work and emergence of complications...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28721297/potential-application-of-bacillus-subtilis-spb1-lipopeptides-in-toothpaste-formulation
#5
Mouna Bouassida, Nada Fourati, Fatma Krichen, Raida Zouari, Semia Ellouz-Chaabouni, Dhouha Ghribi
Toothpaste is a gel dentifrice used with a toothbrush as an accessory to clean, keep and promote oral hygiene. The literature review suggests that there are many different formulations of toothpastes and that each of their individual components present specific functions. The concentration of the toothpaste ingredients must be appropriately chosen taking into account the purposes of the toothpaste. Biosurfactants are considered as suitable molecules for application in many formulations such as in toothpaste one...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28663825/applications-of-ctab-modified-magnetic-nanoparticles-for-removal-of-chromium-vi-from-contaminated-water
#6
Souad A Elfeky, Shymaa Ebrahim Mahmoud, Ahmed Fahmy Youssef
This study investigated the elimination of Cr(VI) from aqueous solution utilizing a composite from magnetic nanoparticles (Fe3O4) capped with cetyltrimethylammonium bromide (CTAB). The structure of the prepared composite system was examined by Fourier Transform Infra Red Spectroscopy (FTIR), X-ray Diffractometry (XRD), and Transmission Electron Microscopy (TEM). Separation of the Fe3O4/CTAB composite from the wastewater can be achieved by application of an external magnetic field. Factors affecting the Cr(VI) expulsion from wastewater such as pH, competing ions, the dosage level of the nanoparticles, and contact time were studied...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28649459/the-study-on-force-surface-integrity-tool-life-and-chip-on-laser-assisted-machining-of-inconel-718-using-nd-yag-laser-source
#7
K Venkatesan
Inconel 718, a high-temperature alloy, is a promising material for high-performance aerospace gas turbine engines components. However, the machining of the alloy is difficult owing to immense shear strength, rapid work hardening rate during turning, and less thermal conductivity. Hence, like ceramics and composites, the machining of this alloy is considered as difficult-to-turn materials. Laser assisted turning method has become a promising solution in recent years to lessen cutting stress when materials that are considered difficult-to-turn, such as Inconel 718 is employed...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28649458/physico-chemical-rheological-and-antioxidant-properties-of-sweet-chestnut-castanea-sativa-mill-as-affected-by-pan-and-microwave-roasting
#8
Idrees Ahmed Wani, Humaira Hamid, Afshan Mumtaz Hamdani, Adil Gani, Bilal Ahmad Ashwar
Sweet chestnut (Castanea sativa Mill.) belongs to the family Fagaceae and sub family Castaneoideae. Bioactive components such as tannins are present in sweet chestnut in high proportion giving astringent bitter taste and reducing their palatability. Roasting reduces the anti-nutritional factors in chestnut. This study was conducted to compare the effects of pan and microwave roasting on physicochemical, functional, rheological and antioxidant properties of sweet chestnut. Antioxidant activity was determined using DPPH inhibition activity, reducing power, and total phenolic content...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28580180/the-role-of-reactive-oxygen-species-in-the-antimicrobial-activity-of-pyochelin
#9
Kuan Shion Ong, Yuen Lin Cheow, Sui Mae Lee
The increase in prevalence of antimicrobial-resistant bacteria (ARB) is currently a serious threat, thus there is a need for new antimicrobial compounds to combat infections caused by these ARB. An antimicrobial-producing bacterium, Burkholderia paludis was recently isolated and was able to produce a type of siderophore with antimicrobial properties, later identified as pyochelin. The chelating ability of pyochelin has been well-characterized but not for its antimicrobial characteristics. It was found that pyochelin had MIC values (MBC values) of 3...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28560054/antibacterial-activity-against-streptococcus-mutans-and-inhibition-of-bacterial-induced-enamel-demineralization-of-propolis-miswak-and-chitosan-nanoparticles-based-dental-varnishes
#10
Mariem O Wassel, Mona A Khattab
Using natural products can be a cost-effective approach for caries prevention especially in low income countries where dental caries is highly prevalent and the resources are limited. Specially prepared dental varnishes containing propolis, miswak, and chitosan nanoparticles (CS-NPs) with or without sodium fluoride (NaF) were assessed for antibacterial effect against Streptococcus mutans (S. mutans) using disk diffusion test. In addition, the protective effect of a single pretreatment of primary teeth enamel specimens against in vitro bacterial induced enamel demineralization was assessed for 3 days...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28560053/volatiles-profiling-in-ceratonia-siliqua-carob-bean-from-egypt-and-in-response-to-roasting-as-analyzed-via-solid-phase-microextraction-coupled-to-chemometrics
#11
Mohamed A Farag, Dina M El-Kersh
Ceratonia siliqua is a legume tree of considerable commercial importance for the flavor and sweets industry cultivated mostly for its pods nutritive value and or several health benefits. Despite extensive studies on C. siliqua pod non-volatile metabolites, much less is known regarding volatiles composition which contributes to the flavor of its many food products. To gain insight into C. siliqua aroma, 31 volatile constituents from unroasted and roasted pods were profiled using headspace solid-phase micro extraction (HD-SPME) analyzed via quadruple mass spectrometer followed by multivariate data analyses...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28560052/genomic-profile-of-a-patient-with-triple-negative-essential-thrombocythemia-unresponsive-to-therapy-a-case-report-and-literature-review
#12
Uzma Zaidi, Saba Shahid, Naveen Fatima, Shariq Ahmed, Gul Sufaida, Muhammad Nadeem, Tahir Shamsi
Clonal analysis of patients with triple negative myeloproliferative neoplasm (MPN) has provided evidence of additional aberrations, including epigenetic alterations. To discover such novel genetic aberrations, patients were screened through next-generation sequencing using a myeloid sequencing panel of 54 genes using a genetic analyser. Genetic variants in 28 genes, including TET2, BCOR, BCR, and ABL1 were identified in a triple negative essential thrombocythemia (ET) patient. The individual role of some of these variants in disease pathogenesis has yet to be studied...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28540086/diabetic-nephropathy-time-to-withhold-development-and-progression-a-review
#13
REVIEW
Usama A A Sharaf El Din, Mona M Salem, Dina O Abdulazim
The recent discoveries in the fields of pathogenesis and management of diabetic nephropathy have revolutionized the knowledge about this disease. Little was added to the management of diabetic nephropathy after the introduction of renin angiotensin system blockers. The ineffective role of the renin- angiotensin system blockers in primary prevention of diabetic nephropathy in type 1 diabetes mellitus necessitated the search for other early therapeutic interventions that target alternative pathogenic mechanisms...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28540085/a-comprehensive-investigation-on-static-and-dynamic-friction-coefficients-of-wheat-grain-with-the-adoption-of-statistical-analysis
#14
S M Shafaei, S Kamgar
This paper deals with studying and modeling static friction coefficient (SFC) and dynamic friction coefficient (DFC) of wheat grain as affected by several treatments. Significance of single effect (SE) and dual interaction effect (DIE) of treatments (moisture content and contact surface) on SFC and, SE, DIE, and triple interaction effect (TIE) of treatments (moisture content, contact surface and sliding velocity) on DFC were determined using statistical analysis methods. Multiple linear regression (MLR) modeling was employed to predict SFC and DFC on different contact surfaces...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28417047/clinical-significance-of-snp-rs2596542-in-histocompatibility-complex-class-i-related-gene-a-promoter-region-among-hepatitis-c-virus-related-hepatocellular-carcinoma-cases
#15
Amal A Mohamed, Ola M Elsaid, Eman A Amer, Heba H Elosaily, Mohamed I Sleem, Shawkat S Gerges, Mohamed A Saleh, Amal El Shimy, Yasmine S El Abd
The major histocompatibility complex class I-related gene A (MICA) is an antigen induced by stress and performs an integral role in immune responses as an anti-infectious and antitumor agent. This work was designed to investigate whether (SNP) rs2596542C/T in MICA promoter region is predictive of liver cirrhosis (LC) and hepatocellular carcinoma (HCC) or not. Forty-seven healthy controls and 94 HCV-infected patients, subdivided into 47 LC and 47 HCC subjects were enrolled in this study. SNP association was studied using real time PCR and soluble serum MICA concentration was measured using ELISA...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28413690/a-dynamic-model-for-gps-based-attitude-determination-and-testing-using-a-serial-robotic-manipulator
#16
Almat Raskaliyev, Sarosh Patel, Tarek Sobh
A computational algorithm is developed for estimating accurately the attitude of a robotic arm which moves along a predetermined path. This algorithm requires preliminary input data obtained in the static mode to yield phase observables for the precise, 3-axis attitude determination of a swinging manipulator in the dynamic mode. Measurements are recorded simultaneously by three GPS L1 receivers and then processed in several steps to accomplish this task. First, artkconv batch executable converts GPS receiver readings into RINEX format to generate GPS observables and ephemeris for multiple satellites...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28386482/long-term-global-temperature-variations-under-total-solar-irradiance-cosmic-rays-and-volcanic-activity
#17
Lilia Biktash
The effects of total solar irradiance (TSI) and volcanic activity on long-term global temperature variations during solar cycles 19-23 were studied. It was shown that a large proportion of climate variations can be explained by the mechanism of action of TSI and cosmic rays (CRs) on the state of the lower atmosphere and other meteorological parameters. The role of volcanic signals in the 11-year variations of the Earth's climate can be expressed as several years of global temperature drop. Conversely, it was shown that the effects of solar, geophysical, and human activity on climate change interact...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28386481/ips-cell-technologies-and-their-prospect-for-bone-regeneration-and-disease-modeling-a-mini-review
#18
REVIEW
Maria Csobonyeiova, Stefan Polak, Radoslav Zamborsky, Lubos Danisovic
Bone disorders are a group of varied acute and chronic traumatic, degenerative, malignant or congenital conditions affecting the musculoskeletal system. They are prevalent in society and, with an ageing population, the incidence and impact on the population's health is growing. Severe persisting pain and limited mobility are the major symptoms of the disorder that impair the quality of life in affected patients. Current therapies only partially treat the disorders, offering management of symptoms, or temporary replacement with inert materials...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28386480/comparative-study-on-the-mechanical-and-microstructural-characterisation-of-aa-7075-nano-and-hybrid-nanocomposites-produced-by-stir-and-squeeze-casting
#19
C Kannan, R Ramanujam
In this research work, a comparative evaluation on the mechanical and microstructural characteristics of aluminium based single and hybrid reinforced nanocomposites was carried out. The manufacture of a single reinforced nanocomposite was conducted with the distribution of 2 wt.% nano alumina particles (avg. particle size 30-50 nm) in the molten aluminium alloy of grade AA 7075; while the hybrid reinforced nanocomposites were produced with of 4 wt.% silicon carbide (avg. particle size 5-10 µm) and 2 wt...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28462003/enhancing-anaerobic-digestion-of-poultry-blood-using-activated-carbon
#20
Maria José Cuetos, E Judith Martinez, Rubén Moreno, Rubén Gonzalez, Marta Otero, Xiomar Gomez
The potential of using anaerobic digestion for the treatment of poultry blood has been evaluated in batch assays at the laboratory scale and in a mesophilic semi-continuous reactor. The biodegradability test performed on residual poultry blood was carried out in spite of high inhibitory levels of acid intermediaries. The use of activated carbon as a way to prevent inhibitory conditions demonstrated the feasibility of attaining anaerobic digestion under extreme ammonium and acid conditions. Batch assays with higher carbon content presented higher methane production rates, although the difference in the final cumulative biogas production was not as sharp...
May 2017: Journal of Advanced Research
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