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Frontiers in Neurology

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https://www.readbyqxmd.com/read/29230194/acute-flaccid-paralysis-by-enterovirus-d68-infection-first-italian-description-in-adult-patient-and-role-of-electrophysiology
#1
Marco Ceccanti, Emilia Sbardella, Federica Letteri, Manuela De Michele, Anne Falcou, Federica Romanzi, Emanuela Onesti, Maurizio Inghilleri
A Peruvian woman was admitted to the Emergency Department, due to an acute flaccid paralysis (AFP) of the upper limbs that progressively involved also lower limbs and respiratory muscles. She previously suffered from non-Hodgkin's lymphoma and had to undergo hematopoietic stem cell transplantation. A magnetic resonance imaging showed a T2 hyperintensity in the anterior and central region of the cervical segment with an elective involvement of gray matter. This finding, combined with other clinical, laboratory, and electrophysiological data, led to a diagnosis of AFP...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29230193/editorial-non-coding-rnas-in-neurodevelopmental-disorders
#2
EDITORIAL
Owen M Rennert, Mark N Ziats
No abstract text is available yet for this article.
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29230192/external-validity-of-randomized-controlled-trials-on-alzheimer-s-disease-the-biases-of-frailty-and-biological-aging
#3
Marco Canevelli, Alessandro Trebbastoni, Federica Quarata, Fabrizia D'Antonio, Matteo Cesari, Carlo de Lena, Giuseppe Bruno
To date, the external validity of randomized controlled trials (RCTs) on Alzheimer's disease (AD) has been assessed only considering monodimensional variables. Nevertheless, looking at isolated and single characteristics cannot guarantee a sufficient level of appreciation of the AD patients' complexity. The only way to understand whether the two worlds (i.e., research and clinics) deal with the same type of patients is to adopt multidimensional approaches more holistically reflecting the biological age of the individual...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29230191/the-reticulospinal-pathway-does-not-increase-its-contribution-to-the-strength-of-contralesional-muscles-in-stroke-survivors-as-compared-to-ipsilesional-side-or-healthy-controls
#4
Sheng Li, Minal Bhadane, Fan Gao, Ping Zhou
Objective: Startling acoustic stimulation (SAS), via activation of reticulospinal (RS) pathways, has shown to increase muscle strength in healthy subjects. We hypothesized that, given RS hyperexcitability in stroke survivors, SAS could increase muscle strength in stroke survivors. The objective was to quantify the effect of SAS on maximal and sub-maximal voluntary elbow flexion on the contralesional (impaired) side in stroke survivors as compared to ipsilesional (non-impaired) side and healthy controls...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29230190/daith-piercing-in-a-case-of-chronic-migraine-a-possible-vagal-modulation
#5
Angelo Cascio Rizzo, Matteo Paolucci, Riccardo Altavilla, Nicoletta Brunelli, Federica Assenza, Claudia Altamura, Fabrizio Vernieri
Daith piercing is an ear piercing located at the crus of the helix, bilaterally. It is getting great consent on social media as alternative treatment in chronic migraine. No data about its efficacy and action are available in scientific literature so far. We present the case of a 54-year-old male patient suffering from refractory chronic migraine with medication-overuse, who substantially improved after bilateral ear daith piercing. His migraine was refractory to symptomatic as well as prophylactic therapies...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29230189/structural-covariance-of-sensory-networks-the-cerebellum-and-amygdala-in-autism-spectrum-disorder
#6
Garrett J Cardon, Susan Hepburn, Donald C Rojas
Sensory dysfunction is a core symptom of autism spectrum disorder (ASD), and abnormalities with sensory responsivity and processing can be extremely debilitating to ASD patients and their families. However, relatively little is known about the underlying neuroanatomical and neurophysiological factors that lead to sensory abnormalities in ASD. Investigation into these aspects of ASD could lead to significant advancements in our general knowledge about ASD, as well as provide targets for treatment and inform diagnostic procedures...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29230188/control-of-rest-activity-by-a-dopaminergic-ultradian-oscillator-and-the-circadian-clock
#7
REVIEW
Clément Bourguignon, Kai-Florian Storch
There is long-standing evidence for rhythms in locomotor activity, as well as various other aspects of physiology, with periods substantially shorter than 24 h in organisms ranging from fruit flies to humans. These ultradian oscillations, whose periods frequently fall between 2 and 6 h, are normally well integrated with circadian rhythms; however, they often lack the period stability and expression robustness of the latter. An adaptive advantage of ultradian rhythms has been clearly demonstrated for the common vole, suggesting that they may have evolved to confer social synchrony...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29218027/corrigendum-assessing-metabolism-and-injury-in-acute-human-traumatic-brain-injury-with-magnetic-resonance-spectroscopy-current-and-future-applications
#8
Matthew G Stovell, Jiun-Lin Yan, Alison Sleigh, Marius O Mada, T Adrian Carpenter, Peter J A Hutchinson, Keri L H Carpenter
[This corrects the article on p. 426 in vol. 8, PMID: 28955291.].
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29213254/blue-light-therapy-following-mild-traumatic-brain-injury-effects-on-white-matter-water-diffusion-in-the-brain
#9
Sahil Bajaj, John R Vanuk, Ryan Smith, Natalie S Dailey, William D S Killgore
Mild traumatic brain injury (mTBI) is a common and often inconspicuous wound that is frequently associated with chronic low-grade symptoms and cognitive dysfunction. Previous evidence suggests that daily blue wavelength light therapy may be effective at reducing fatigue and improving sleep in patients recovering from mTBI. However, the effects of light therapy on recovering brain structure remain unexplored. In this study, we analyzed white matter diffusion properties, including generalized fractional anisotropy, and the quantity of water diffusion in isotropic (i...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29209272/a-european-perspective-on-auditory-processing-disorder-current-knowledge-and-future-research-focus
#10
Vasiliki Vivian Iliadou, Martin Ptok, Helen Grech, Ellen Raben Pedersen, André Brechmann, Naïma Deggouj, Christiane Kiese-Himmel, Mariola Śliwińska-Kowalska, Andreas Nickisch, Laurent Demanez, Evelyne Veuillet, Hung Thai-Van, Tony Sirimanna, Marina Callimachou, Rosamaria Santarelli, Sandra Kuske, Jose Barajas, Mladen Hedjever, Ozlem Konukseven, Dorothy Veraguth, Tone Stokkereit Mattsson, Jorge Humberto Martins, Doris-Eva Bamiou
Current notions of "hearing impairment," as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday life that are indexed by reduced performance in other more sophisticated audiometric tests such as speech audiometry in noise or complex non-speech sound perception. This disorder, defined as "Auditory Processing Disorder" (APD) or "Central Auditory Processing Disorder" is classified in the current tenth version of the International Classification of diseases as H93...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29209271/development-and-implementation-of-a-new-telerehabilitation-system-for-audiovisual-stimulation-training-in-hemianopia
#11
Francesca Tinelli, Giovanni Cioni, Giulia Purpura
Telerehabilitation, defined as the method by which communication technologies are used to provide remote rehabilitation, although still underused, could be as efficient and effective as the conventional clinical rehabilitation practices. In the literature, there are descriptions of the use of telerehabilitation in adult patients with various diseases, whereas it is seldom used in clinical practice with child and adolescent patients. We have developed a new audiovisual telerehabilitation (AVT) system, based on the multisensory capabilities of the human brain, to provide a new tool for adults and children with visual field defects in order to improve ocular movements toward the blind hemifield...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29209270/transcranial-direct-current-stimulation-in-patients-with-prolonged-disorders-of-consciousness-combined-behavioral-and-event-related-potential-evidence
#12
Ye Zhang, Weiqun Song, Jubao Du, Su Huo, Guixiang Shan, Ran Li
Background: The electrophysiological evidence supporting the therapeutic efficacy of multiple transcranial direct current stimulation (tDCS) sessions on consciousness improvement in patients with prolonged disorders of consciousness (DOCs) has not been firmly established. Objectives: To assess the effects of repeated tDCS in patients with prolonged DOCs by Coma Recovery Scale-Revised (CRS-R) score and event-related potential (ERP). Method: Using a sham-controlled randomized double-blind design, 26 patients were randomly assigned to either a real [five vegetative state (VS) and eight minimally conscious state (MCS) patients] or sham (six VS and seven MCS patients) stimulation group...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29209269/if-time-is-brain-where-is-the-improvement-in-prehospital-time-after-stroke
#13
REVIEW
Jeremy N Pulvers, John D G Watson
Despite the availability of thrombolytic and endovascular therapy for acute ischemic stroke, many patients are ineligible due to delayed hospital arrival. The identification of factors related to either early or delayed hospital arrival may reveal potential targets of intervention to reduce prehospital delay and improve access to time-critical thrombolysis and clot retrieval therapy. Here, we have reviewed studies reporting on factors associated with either early or delayed hospital arrival after stroke, together with an analysis of stroke onset to hospital arrival times...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29209268/implementation-and-evaluation-of-an-economic-model-for-telestroke-experience-from-virtuall-france
#14
Nolwenn Riou-Comte, Gioia Mione, Lisa Humbertjean, Arielle Brunner, Arnaud Vezain, Karine Lavandier, Sophie Marchal, Serge Bracard, Marc Debouverie, Sébastien Richard
Background: Telestroke is recognized as a safe and time-efficient way of treating stroke patients. However, admission centers (spokes) are subject to financial charges which can make them reluctant to join the system. We implemented and assessed an economic model supporting our telestroke system, Virtuall, France, which includes one expert center (hub) and six spokes. Methods: The model is based on payment for the expertise provided by the hub, distribution of charges related to telemedicine according to the fees perceived by the spokes, and transfer of patients between the spokes and the hub...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29209267/transition-from-acute-to-chronic-tinnitus-predictors-for-the-development-of-chronic-distressing-tinnitus
#15
Elisabeth Wallhäusser-Franke, Roberto D'Amelio, Anna Glauner, Wolfgang Delb, Jérôme J Servais, Karl Hörmann, Ines Repik
Background: Acute tinnitus and its transition to chronic tinnitus are poorly investigated, and factors associated with amelioration versus exacerbation are largely unknown. Aims of this study were to identify early predictors for the future development of tinnitus severity. Method: Patients with tinnitus of no longer than 4 weeks presenting at an otolaryngologist filled out questionnaires at inclusion (T1), as well as 3 (T3), and 6 months (T4) after tinnitus onset...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29209266/current-opportunities-for-clinical-monitoring-of-axonal-pathology-in-traumatic-brain-injury
#16
REVIEW
Parmenion P Tsitsopoulos, Sami Abu Hamdeh, Niklas Marklund
Traumatic brain injury (TBI) is a multidimensional and highly complex disease commonly resulting in widespread injury to axons, due to rapid inertial acceleration/deceleration forces transmitted to the brain during impact. Axonal injury leads to brain network dysfunction, significantly contributing to cognitive and functional impairments frequently observed in TBI survivors. Diffuse axonal injury (DAI) is a clinical entity suggested by impaired level of consciousness and coma on clinical examination and characterized by widespread injury to the hemispheric white matter tracts, the corpus callosum and the brain stem...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29201015/role-of-perinatal-inflammation-in-neonatal-arterial-ischemic-stroke
#17
REVIEW
Antoine Giraud, Clémence Guiraut, Mathilde Chevin, Stéphane Chabrier, Guillaume Sébire
Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susceptible arteries and neonatal brain. A top research priority in NAIS is to further characterize the nature and spatiotemporal features of the inflammatory processes involved in multiple levels of the pathophysiology of NAIS, to adequately design randomized control trials using targeted anti-inflammatory vasculo- and neuroprotective agents...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29201014/impaired-interoceptive-accuracy-in-semantic-variant-primary-progressive-aphasia
#18
Charles R Marshall, Chris J D Hardy, Lucy L Russell, Camilla N Clark, Katrina M Dick, Emilie V Brotherhood, Rebecca L Bond, Catherine J Mummery, Jonathan M Schott, Jonathan D Rohrer, James M Kilner, Jason D Warren
Background: Interoception (the perception of internal bodily sensations) is strongly linked to emotional experience and sensitivity to the emotions of others in healthy subjects. Interoceptive impairment may contribute to the profound socioemotional symptoms that characterize frontotemporal dementia (FTD) syndromes, but remains poorly defined. Methods: Patients representing all major FTD syndromes and healthy age-matched controls performed a heartbeat counting task as a measure of interoceptive accuracy...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29187832/isolated-horizontal-gaze-palsy-observations-and-explanations
#19
Renee Ewe, Owen B White, Ailbhe Burke
We present three cases that we suggest require a novel diagnosis and a reconsideration of current understandings of pontine anatomy. In this case series, we highlight a series of patients with monophasic, fully recovering inflammatory lesions in the pontine tegmentum not due to any of the currently recognized causes of this syndrome. We highlight other similar cases in the literature and suggest there may be a particular epitope for an as-yet-undiscovered antibody underlying the tropism for this area. We highlight the potential harm of misdiagnosis with relapsing inflammatory or other serious diagnoses with significant adverse impact on the patient...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29184534/pronounced-structural-and-functional-damage-in-early-adult-pediatric-onset-multiple-sclerosis-with-no-or-minimal-clinical-disability
#20
Antonio Giorgio, Jian Zhang, Maria Laura Stromillo, Francesca Rossi, Marco Battaglini, Lucia Nichelli, Marzia Mortilla, Emilio Portaccio, Bahia Hakiki, Maria Pia Amato, Nicola De Stefano
Pediatric-onset multiple sclerosis (POMS) may represent a model of vulnerability to damage occurring during a period of active maturation of the human brain. Whereas adaptive mechanisms seem to take place in the POMS brain in the short-medium term, natural history studies have shown that these patients reach irreversible disability, despite slower progression, at a significantly younger age than adult-onset MS (AOMS) patients. We tested for the first time whether significant brain alterations already occurred in POMS patients in their early adulthood and with no or minimal disability (n = 15) in comparison with age- and disability-matched AOMS patients (n = 14) and to normal controls (NC, n = 20)...
2017: Frontiers in Neurology
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