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Frontiers in Neurology

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https://www.readbyqxmd.com/read/30519214/corrigendum-validation-of-a-questionnaire-for-distinguishing-x-linked-dystonia-parkinsonism-from-its-mimics
#1
Jose Danilo B Diestro, Mark Angelo C Ang, Mark Willy L Mondia, Paul Matthew D Pasco
[This corrects the article DOI: 10.3389/fneur.2018.00830.].
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30519213/cerebral-microbleeds-in-the-patients-with-acute-stroke-symptoms
#2
Sung Hyuk Heo, Dongwhane Lee, Yong Chul Kwon, Bum Joon Kim, Kyung Mi Lee, Cheryl D Bushnell, Dae-Il Chang
Background: Some patients with acute stroke symptoms do not show hyperintensities on diffusion-weighted image (DWI). A few case reports have indicated that acutely developed cerebral microbleeds (CMBs) might cause focal symptoms. This study sought to investigate the incidence and characteristics of symptomatic CMBs in the patients with acute stroke symptoms but without DWI ischemic lesions. Methods: We enrolled the patients with acute stroke symptoms who underwent magnetic resonance imaging including DWI and gradient echo (GRE) sequences within 7 days after symptom onset, at our prospective stroke registry...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30519212/white-matter-changes-along-the-electrode-lead-in-patients-treated-with-deep-brain-stimulation
#3
Richard Erasmi, Oliver Granert, Dmitry Zorenkov, Daniela Falk, Fritz Wodarg, Günther Deuschl, Karsten Witt
Introduction: Deep brain stimulation (DBS) is an established treatment for various movement disorders. There is little data available about the potential damage to brain parenchyma through DBS treatment. The objective of this study was to investigate the occurrence of signal changes on magnetic resonance imaging (MRI) in patients treated with DBS. Methods: We retrospectively analyzed MRI scans of 30 DBS patients (21 patients with Parkinson's disease, 3 patients with dystonia and 6 patients with tremor) that had undergone additional MRI scans after DBS surgery (ranging from 2 months to 8 years)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30519211/behavioral-and-resting-state-functional-connectivity-effects-of-high-frequency-rtms-on-disorders-of-consciousness-a-sham-controlled-study
#4
Xiaoyan Liu, Fanxia Meng, Jian Gao, Li Zhang, Zhen Zhou, Gang Pan, Benyan Luo
Objectives: A combined approach of behavioral characteristics and network properties was applied to explore the effect of repetitive transcranial magnetic stimulation (rTMS) on disorders of consciousness (DOC) and to observe changes in brain network connections before and after the stimulation. Methods: A total of 7 DOC patients and 11 healthy controls were enrolled. The study was designed as a randomized, sham-controlled study. All DOC patients were given 20 Hz rTMS real and sham stimuli to the left M1 region, with each stimulus lasting for 5 consecutive working days and the interval between two stimuli being 1 week...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30519210/association-of-stress-and-musculoskeletal-pain-with-poor-sleep-cross-sectional-study-among-3-600-hospital-workers
#5
Jonas Vinstrup, Markus Due Jakobsen, Joaquin Calatayud, Kenneth Jay, Lars Louis Andersen
Background: While acute stress and pain are part of our inherent survival mechanisms, persistent stress and pain can negatively impact health and well-being. This may also lead to poor sleep and thus a lack of recovery. This study investigated the influence of stress and musculoskeletal pain on sleep quality. Methods: A total of 3,593 Danish hospital workers replied to a questionnaire about work and health. Pain intensity was evaluated using subjective values as an average of 9 body parts. Stress was assessed using the full version of Cohen's Perceived Stress scale...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30515129/risk-factors-in-predicting-prognosis-of-neonatal-bacterial-meningitis-a-systematic-review
#6
Dan-Hua Mao, Jing-Kun Miao, Xian Zou, Na Chen, Lin-Chao Yu, Xin Lai, Meng-Yuan Qiao, Qi-Xiong Chen
Background: Neonatal bacterial meningitis is a severe infection with high mortality and morbidity. It is necessary to identify factors associated with a high risk of a poor prognosis so that we can prevent them with more appropriate treatments. This study was performed to summarize the prognostic factors known to predict adverse outcomes in neonatal bacterial meningitis. Methods: The Medline/PubMed, Cochrane Library and Embase databases were searched for studies of prognostic risk factors in neonates with bacterial meningitis...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30515128/temperature-management-with-paracetamol-in-acute-stroke-patients-evidence-from-randomized-controlled-trials
#7
Huawei Chen, Hui Qian, Zhiwei Gu, Majun Wang
Whether or not paracetamol can improve functional outcomes in patients with acute stroke has been examined in several clinical trials. The inconsistent results of these trials have caused great controversy regarding the need for further studies. In the present meta-analysis, we have aimed to address this controversy. The main databases (Medline, Embase, and Cochrane Library) were searched for randomized controlled trials involving the use of paracetamol in acute stroke patients. Pooled relative risks (RRs) or mean differences (MDs) and 95% confidence intervals (CIs) were calculated using a random-effects model...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30510538/functional-head-impulse-testing-might-be-useful-for-assessing-vestibular-compensation-after-unilateral-vestibular-loss
#8
Julia Sjögren, Per-Anders Fransson, Mikael Karlberg, Måns Magnusson, Fredrik Tjernström
Background: Loss of the vestibulo-ocular reflex (VOR) affects visual acuity during head movements. Previous studies have shown that compensatory eye-saccades improve visual acuity and that the timing of the saccade is important. Most of the tests involved in testing VOR are made with passive head movement, that do not necessarily reflect the activities of daily living and thus not being proportionate to symptoms and distresses of the patients. Objective: To examine differences between active (self-generated) or passive (imposed by the examiner) head rotations while trying to maintain visual focus on a target...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30510537/hd-eeg-based-classification-of-motor-imagery-related-activity-in-patients-with-spinal-cord-injury
#9
Yvonne Höller, Aljoscha Thomschewski, Andreas Uhl, Arne C Bathke, Raffaele Nardone, Stefan Leis, Eugen Trinka, Peter Höller
Brain computer interfaces (BCIs) are thought to revolutionize rehabilitation after SCI, e.g., by controlling neuroprostheses, exoskeletons, functional electrical stimulation, or a combination of these components. However, most BCI research was performed in healthy volunteers and it is unknown whether these results can be translated to patients with spinal cord injury because of neuroplasticity. We sought to examine whether high-density EEG (HD-EEG) could improve the performance of motor-imagery classification in patients with SCI...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30510536/rare-copy-number-variations-and-predictors-in-children-with-intellectual-disability-and-epilepsy
#10
Miriam Kessi, Juan Xiong, Liwen Wu, Lifen Yang, Fang He, Chen Chen, Nan Pang, Haolin Duan, Wen Zhang, Ahmed Arafat, Fei Yin, Jing Peng
Introduction: The concurrence of intellectual disability/global developmental delay and epilepsy (ID/GDD-EP) is very common in the pediatric population. The etiologies for both conditions are complex and largely unknown. The predictors of significant copy number variations (CNVs) are known for the cases with ID/GDD, but unknown for those with exclusive ID/GDD-EP. Importantly, the known predictors are largely from the same ethnic group; hence, they lack replication. Purpose: We aimed to determine and investigate the diagnostic yield of CNV tests, new causative CNVs, and the independent predictors of significant CNVs in Chinese children with unexplained ID/GDD-EP...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30510535/exploratory-investigation-of-intestinal-function-and-bacterial-translocation-after-focal-cerebral-ischemia-in-the-mouse
#11
Naoki Oyama, Katarzyna Winek, Priscilla Bäcker-Koduah, Tian Zhang, Claudia Dames, Martina Werich, Olivia Kershaw, Christian Meisel, Andreas Meisel, Ulrich Dirnagl
Background and Purpose: The gut communicates with the brain bidirectionally via neural, humoral and immune pathways. All these pathways are affected by acute brain lesions, such as stroke. Brain-gut communication may therefore impact on the overall outcome after CNS-injury. Until now, contradictory reports on intestinal function and translocation of gut bacteria after experimental stroke have been published. Accordingly, we aimed to specifically investigate the effects of transient focal cerebral ischemia on intestinal permeability, gut associated lymphoid tissue and bacterial translocation in an exploratory study using a well-characterized murine stroke model...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30510534/a-simple-and-rapid-puncture-method-for-draining-hematoma-in-pontine-hemorrhage
#12
Mingzhe Zhang, Raynald Liu, Hongli Xing, Huixuan Luo, Leiting Cui, Zhaosheng Sun
We present a patient with pontine hemorrhage. On admission, the patient was in a comatose state (Glasgow coma scale, 3). Due to rapid deterioration of his breathing, we immediately performed a direct puncture to the hematoma site. We present a simple and rapid puncture method for drainage of hematomas. The method is described and discussed in detail in this article. The described technique may be beneficial in emergency situations where the condition of the patient, particularly their respiration is declining rapidly...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30505289/effect-of-rotating-auditory-scene-on-postural-control-in-normal-subjects-patients-with-bilateral-vestibulopathy-unilateral-or-bilateral-cochlear-implants
#13
Caroline Guigou, Michel Toupet, Benoit Delemps, Sylvie Heuschen, Serge Aho, Alexis Bozorg Grayeli
Objective: The aim of this study was to investigate the impact of a rotating sound stimulation on the postural performances in normal subjects, patients with bilateral vestibulopathy (BVP), unilateral (UCI), and bilateral (BCI) cochlear implantees. Materials and Methods: Sixty-nine adults were included (32 women and 37 men) in a multicenter prospective study. The group included 37 healthy subjects, 10 BVP, 15 UCI, and 7 BCI patients. The average of age was 47 ± 2.0 (range: 23-82). In addition to a complete audiovestibular work up, a dynamic posturography (Multitest Framiral, Grasse) was conducted in silence and with a rotating cocktail party sound delivered by headphone...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30498474/microglia-in-alzheimer-s-disease-risk-factors-and-inflammation
#14
REVIEW
Atsuko Katsumoto, Hideyuki Takeuchi, Keita Takahashi, Fumiaki Tanaka
Microglia are resident immune cells in the central nervous system (CNS) that originate from myeloid progenitor cells in the embryonic yolk sac and are maintained independently of circulating monocytes throughout life. In the healthy state, microglia are highly dynamic and control the environment by rapidly extending and retracting their processes. When the CNS is inflamed, microglia can give rise to macrophages, but the regulatory mechanisms underlying this process have not been fully elucidated. Recent genetic studies have suggested that microglial function is compromised in Alzheimer's disease (AD), and that environmental factors such as diet and brain injury also affect microglial activation...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30498473/familial-hemiplegic-migraine-type-3-fhm3-with-an-scn1a-mutation-in-a-chinese-family-a-case-report
#15
Na Shao, Haining Zhang, Xue Wang, Wuqiong Zhang, Miaomiao Yu, Hongmei Meng
Familial hemiplegic migraine (FHM) is a rare, monogenic, autosomal dominant subtype of migraine, in which three genes, CACNA1A, ATP1A2 , and SCN1A , are currently known to be involved. The familial hemiplegic migraine type 3 (FHM3) is seldom caused by mutations in SCN1A . Here, we report a rare case of an SCN1A mutation leading to FHM3 in a Chinese family. This case report describes a 62-year-old female patient that was admitted to our clinic. She presented with recurrent attacks of hemiplegic migraine. Her symptoms were first suspicious of a transient ischemic attack (TIA), but they were eventually diagnosed as FHM with a c...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30498472/identification-of-mild-cognitive-impairment-from-speech-in-swedish-using-deep-sequential-neural-networks
#16
Charalambos Themistocleous, Marie Eckerström, Dimitrios Kokkinakis
While people with mild cognitive impairment (MCI) portray noticeably incipient memory difficulty in remembering events and situations along with problems in decision making, planning, and finding their way in familiar environments, detailed neuropsychological assessments also indicate deficits in language performance. To this day, there is no cure for dementia but early-stage treatment can delay the progression of MCI; thus, the development of valid tools for identifying early cognitive changes is of great importance...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30498471/prevalence-of-stroke-and-hypoperfusion-in-patients-with-isolated-vertigo-and-vascular-risk-factors
#17
Dao Pei Zhang, Hao Ran Li, Qian Kun Ma, Suo Yin, Yan Fang Peng, Huai Liang Zhang, Min Zhao, Shu Ling Zhang
Background and Purpose: The aim of this study was to determine the prevalence and associated factors of stroke and hypoperfusion among patients with isolated vertigo and vascular risk factors. Methods: We studied 157 patients with isolated vertigo who had undergone multimodal magnetic resonance imaging. Magnetic resonance angiography (MRA) was used to measure the diameters of vertebrobasilar arteries and to evaluate morphologic changes to vessels. Measurements obtained included length of the basilar artery and curvature index for the vertebral artery (VA)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30498470/hla-polymorphism-affects-risk-of-de-novo-mutation-of-dystrophin-gene-and-clinical-severity-of-duchenne-muscular-dystrophy-in-a-southern-chinese-population
#18
Huan Li, Lulu Xiao, Liang Wang, Jinfu Lin, Min Luo, Menglong Chen, Ruojie He, Yuling Zhu, Cheng Zhang
Immune-mediated pathology has been thought to be an important factor contributing to Duchenne muscular dystrophy (DMD). Allele frequencies of certain HLA types are known to differ between patients with dystrophinopathies and healthy controls with low-resolution HLA gene typing data in limit reports. Using Polymerase chain reactionsequence based typing (PCR-SBT) to genotype 64 children with DMD in HLA-A , -B,-C, -DRB1, and -DQB1 locus and 503 healthy controls in HLA-A , - B, -DRB1 locus, this study aimed to investigate associations of specific HLA alleles with, and their possible roles in the development and clinical phenotypic severity of DMD...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30498469/early-microglial-activation-following-closed-head-concussive-injury-is-dominated-by-pro-inflammatory-m-1-type
#19
Sindhu K Madathil, Bernard S Wilfred, Sarah E Urankar, Weihong Yang, Lai Yee Leung, Janice S Gilsdorf, Deborah A Shear
Microglial activation is a pathological hallmark of traumatic brain injury (TBI). Following brain injury, activated microglia/macrophages adopt different phenotypes, generally categorized as M-1, or classically activated, and M-2, or alternatively activated. While the M-1, or pro-inflammatory phenotype is detrimental to recovery, M-2, or the anti-inflammatory phenotype, aids in brain repair. Recent findings also suggest the existence of mixed phenotype following brain injury, where activated microglia simultaneously express both M-1 and M-2 markers...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30498468/a-chromosomal-deletion-and-new-frameshift-mutation-cause-arsacs-in-an-african-american
#20
Sean C Dougherty, Amy Harper, Hind Al Saif, Gregory Vorona, Scott R Haines
Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) is a rare, progressive, neurodegenerative disease characterized by ataxia, spasticity and polyneuropathy. First described in the French-Canadian population of Quebec in 1978, ARSACS has since been identified in multiple patients worldwide. In this clinical case report, we describe the evaluation of an 11-years-old African-American male who presented to neuromuscular clinic for assessment of a gait abnormality. He had a history of gross motor delay since early childhood, frequent falls and a below average IQ...
2018: Frontiers in Neurology
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