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International Journal of Nephrology

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https://www.readbyqxmd.com/read/27885341/characteristics-of-the-relationship-of-kidney-dysfunction-with-cardiovascular-disease-in-high-risk-patients-with-diabetes
#1
Attilio Losito, Loretta Pittavini, Ivano Zampi, Elena Zampi
We aimed at comparing the relationship of reduced estimated glomerular filtration rate (eGFR) with cardiovascular disease (CVD) and mortality between high risk patients with and without type 2 diabetes mellitus (T2DM). The cross-sectional study evaluated 16,298 participants (1,627 T2DM) acutely admitted to hospital. The longitudinal study comprised 7,508 patients (673 with diabetes and 6,835 without). eGFR was categorized into 6 stages from >90 to <15 mL/min/1.73 m(2). Kidney dysfunction was defined by an eGFR < 60 mL/min/1...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27885340/acute-kidney-injury-in-hematopoietic-stem-cell-transplantation-a-review
#2
REVIEW
Vinod Krishnappa, Mohit Gupta, Gurusidda Manu, Shivani Kwatra, Osei-Tutu Owusu, Rupesh Raina
Hematopoietic stem cell transplantation (HSCT) is a highly effective treatment strategy for lymphoproliferative disorders and bone marrow failure states including aplastic anemia and thalassemia. However, its use has been limited by the increased treatment related complications, including acute kidney injury (AKI) with an incidence ranging from 20% to 73%. AKI after HSCT has been associated with an increased risk of mortality. The incidence of AKI reported in recipients of myeloablative allogeneic transplant is considerably higher in comparison to other subclasses mainly due to use of cyclosporine and development of graft-versus-host disease (GVHD) in allogeneic groups...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27830089/proteasome-activators-pa28%C3%AE-and-pa28%C3%AE-govern-development-of-microvascular-injury-in-diabetic-nephropathy-and-retinopathy
#3
Saeed Yadranji Aghdam, Ali Mahmoudpour
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are major complications of type 1 and type 2 diabetes. DN and DR are mainly caused by injury to the perivascular supporting cells, the mesangial cells within the glomerulus, and the pericytes in the retina. The genes and molecular mechanisms predisposing retinal and glomerular pericytes to diabetic injury are poorly characterized. In this study, the genetic deletion of proteasome activator genes, PA28α and PA28β genes, protected the diabetic mice in the experimental STZ-induced diabetes model against renal injury and retinal microvascular injury and prolonged their survival compared with wild type STZ diabetic mice...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27807482/psychosocial-factors-in-end-stage-kidney-disease-patients-at-a-tertiary-hospital-in-australia
#4
Charan Bale, Alexandra Douglas, Dev Jegatheesan, Linh Pham, Sonny Huynh, Atul Mulay, Dwarakanathan Ranganathan
Aim. This study seeks to review the psychosocial factors affecting patients with end-stage kidney disease (ESKD) from a tertiary hospital in Australia. Methods. We audited patients with ESKD, referred to social work services from January 2012 to December 2014. All patients underwent psychosocial assessments by one, full-time renal social worker. Patient demographics, cumulative social issues, and subsequent interventions were recorded directly into a database. Results. Of the 244 patients referred, the majority were >60 years (58...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27803814/is-anticoagulation-discontinuation-achievable-with-citrate-dialysate-during-hdf-sessions
#5
Thibault Dolley-Hitze, Emmanuel Oger, Didier Hamel, Marie-Laure Lombart, Isabelle Hermès
Citrate dialysate has been developed for few years to replace acetate and HCl concentrates. In Online Postdilution Hemodiafiltration (OL-POST-HDF), several issues are remaining concerning the possibility of stopping anticoagulation during sessions and the side effects of citrate solutions on calcium metabolism. This 1-year monocentric retrospective study included all patients exposed to citrate in OL-POST-HDF with nadroparin decrease for more than one month. Clotting events, serum calcium, PTH, hemoglobin, CRP, depuration parameters, and treatments administrated were recorded for analysis...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27656294/dialysate-white-blood-cell-change-after-initial-antibiotic-treatment-represented-the-patterns-of-response-in-peritoneal-dialysis-related-peritonitis
#6
Pichaya Tantiyavarong, Opas Traitanon, Piyatida Chuengsaman, Jayanton Patumanond, Adis Tasanarong
Background. Patients with peritoneal dialysis-related peritonitis usually have different responses to initial antibiotic treatment. This study aimed to explore the patterns of response by using the changes of dialysate white blood cell count on the first five days of the initial antibiotic treatment. Materials and Methods. A retrospective cohort study was conducted. All peritoneal dialysis-related peritonitis episodes from January 2014 to December 2015 were reviewed. We categorized the patterns of antibiotic response into 3 groups: early response, delayed response, and failure group...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27642522/acute-kidney-injury-and-atypical-features-during-pediatric-poststreptococcal-glomerulonephritis
#7
Rose M Ayoob, Andrew L Schwaderer
The most common acute glomerulonephritis in children is poststreptococcal glomerulonephritis (PSGN) usually occurring between 3 and 12 years old. Hypertension and gross hematuria are common presenting symptoms. Most PSGN patients do not experience complications, but rapidly progressive glomerulonephritis and hypertensive encephalopathy have been reported. This paper reports 17 patients seen in 1 year for PSGN including 4 with atypical PSGN, at a pediatric tertiary care center. Seventeen children (11 males), mean age of 8 years, were analyzed...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27597898/impact-of-pediatric-chronic-dialysis-on-long-term-patient-outcome-single-center-study
#8
Daniella Levy Erez, Irit Krause, Amit Dagan, Roxana Cleper, Yafa Falush, Miriam Davidovits
Objective. Owing to a shortage of kidney donors in Israel, children with end-stage renal disease (ESRD) may stay on maintenance dialysis for a considerable time, placing them at a significant risk. The aim of this study was to understand the causes of mortality. Study Design. Clinical data were collected retrospectively from the files of children on chronic dialysis (>3 months) during the years 1995-2013 at a single pediatric medical center. Results. 110 patients were enrolled in the study. Mean age was 10...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27529033/prevalence-and-risk-factors-of-lower-limb-amputation-in-patients-with-end-stage-renal-failure-on-dialysis-a-systematic-review
#9
REVIEW
Rajit A Gilhotra, Beverly T Rodrigues, Venkat N Vangaveti, Usman H Malabu
Background. Renal dialysis has recently been recognised as a risk factor for lower limb amputation (LLA). However, exact rates and associated risk factors for the LLA are incompletely understood. Aim. Prevalence and risk factors of LLA in end-stage renal failure (ESRF) subjects on renal dialysis were investigated from the existing literature. Methods. Published data on the subject were derived from MEDLINE, PubMed, and Google Scholar search of English language literature from January 1, 1980, to July 31, 2015, using designated key words...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27525120/effects-of-therapy-on-urine-neutrophil-gelatinase-associated-lipocalin-in-nondiabetic-glomerular-diseases-with-proteinuria
#10
Amnuay Sirisopha, Somlak Vanavanan, Anchalee Chittamma, Bunyong Phakdeekitcharoen, Ammarin Thakkinstian, Amornpan Lertrit, Nuankanya Sathirapongsasuti, Chagriya Kitiyakara
Urine neutrophil gelatinase-associated lipocalin (NGAL) is widely used as a biomarker for acute kidney injury. Cross-sectional studies have shown that NGAL may be elevated in glomerular diseases, but there is limited information on the value of NGAL in predicting treatment response or on the changes of NGAL levels after therapy. We prospectively evaluated the effects of therapy on NGAL in nondiabetic glomerular diseases. Urine NGAL was collected at biopsy and follow-up at 12 months. At baseline, NGAL in glomerular disease patients (n = 43) correlated with proteinuria, but not with glomerular filtration rate (GFR)...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27493801/prevalence-of-hypercalcaemia-in-a-renal-transplant-population-a-single-centre-study
#11
Tony Amin, P Toby Coates, Jeffrey Barbara, Paul Hakendorf, Nazmul Karim
Introduction. Postrenal transplant bone disease is a significant problem. Factors influencing postrenal transplant bone status include high dose acute and low dose long-term steroid use, persistent hypercalcaemia, and graft failure. In this study, we aimed to determine the prevalence of hypercalcaemia and to evaluate the risk factors for postrenal transplant hypercalcaemia in long-term renal transplant patients at our centre. Methods. This is a biochemical audit in which we studied renal transplant recipients from the Central Northern Adelaide Renal Transplant Services, South Australia...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27478637/hypoxia-associated-proteolytic-processing-of-os-9-by-the-metalloproteinase-meprin-%C3%AE
#12
Barry Lee Martin, Sabena Michelle Conley, Regine Simone Harris, Corshe Devon Stanley, Jean-Marie Vianney Niyitegeka, Elimelda Moige Ongeri
Meprin metalloproteases play a role in the pathology of ischemia/reperfusion- (IR-) induced renal injury. The endoplasmic reticulum-associated protein, osteosarcoma-9 (OS-9), has been shown to interact with the carboxyl-terminal tail of meprin β. More importantly, OS-9 interacts with the hypoxia inducible factor-1α (HIF-1α) and the prolyl-hydroxylase, proteins which mediate the cell's response to hypoxia. To determine if OS-9 is a meprin substrate, kidney proteins from meprin αβ knockout mice (αβKO) (which lack endogenous meprins) and purified human OS-9 were incubated with activated forms of meprin A and meprin B, and Western blot analysis was used to evaluate proteolytic processing of OS-9...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27446612/long-term-follow-up-evaluation-of-renal-function-in-patients-with-chronic-kidney-disease-undergoing-cardiac-surgery
#13
Eduesley Santana-Santos, Felipe Kenji Oshiro Kamei, Tarcísia Karoline do Nascimento, Anas Abou Ismail, Jurema da Silva Herbas Palomo, Marcia Cristina da Silva Magro, Fátima Gil Ferreira, Larissa Bertacchini de Oliveira, Adriano Rogério Baldacin Rodrigues, José Jayme Galvão de Lima
Background. Acute kidney injury (AKI) is a common complication of cardiac surgery but its long-term consequences, in patients with chronic kidney disease (CKD), are not known. Methods. We compared the long-term prognoses of CKD patients who developed (n = 23) and did not develop (n = 35) AKI during the period of hospitalization after undergoing coronary artery bypass graft (CABG). Fifty-eight patients who survived (69.6 ± 8.4 years old, 72% males, 83% Whites, 52% diabetics, baseline GFR: 46 ± 16 mL/min) were followed up for 47...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27298736/erythropoietin-dose-and-mortality-in-hemodialysis-patients-marginal-structural-model-to-examine-causality
#14
Elani Streja, Jongha Park, Ting-Yan Chan, Janet Lee, Melissa Soohoo, Connie M Rhee, Onyebuchi A Arah, Kamyar Kalantar-Zadeh
It has been previously reported that a higher erythropoiesis stimulating agent (ESA) dose in hemodialysis patients is associated with adverse outcomes including mortality; however the causal relationship between ESA and mortality is still hotly debated. We hypothesize ESA dose indeed exhibits a direct linear relationship with mortality in models of association implementing the use of a marginal structural model (MSM), which controls for time-varying confounding and examines causality in the ESA dose-mortality relationship...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27293888/urinary-markers-of-tubular-injury-in-early-diabetic-nephropathy
#15
REVIEW
Temesgen Fiseha, Zemenu Tamir
Diabetic nephropathy (DN) is a common and serious complication of diabetes associated with adverse outcomes of renal failure, cardiovascular disease, and premature mortality. Early and accurate identification of DN is therefore of critical importance to improve patient outcomes. Albuminuria, a marker of glomerular involvement in early renal damage, cannot always detect early DN. Thus, more sensitive and specific markers in addition to albuminuria are needed to predict the early onset and progression of DN. Tubular injury, as shown by the detection of tubular injury markers in the urine, is a critical component of the early course of DN...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27247801/single-nucleotide-polymorphisms-in-pediatric-idiopathic-nephrotic-syndrome
#16
Maija Suvanto, Timo Jahnukainen, Marjo Kestilä, Hannu Jalanko
Polymorphic variants in several molecules involved in the glomerular function and drug metabolism have been implicated in the pathophysiology of pediatric idiopathic nephrotic syndrome (INS), but the results remain inconsistent. We analyzed the association of eleven allelic variants in eight genes (angiopoietin-like 4 (ANGPTL4), glypican 5 (GPC5), interleukin-13 (IL-13), macrophage migration inhibitory factor (MIF), neural nitric oxide synthetase (nNOS), multidrug resistance-1 (MDR1), glucocorticoid-induced transcript-1 (GLCCI1), and nuclear receptor subfamily-3 (NR3C1)) in 100 INS patients followed up till adulthood...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27144022/population-based-trends-in-the-incidence-of-hospital-admission-for-the-diagnosis-of-hepatorenal-syndrome-1998-2011
#17
Manish Suneja, Fan Tang, Joseph E Cavanaugh, Linnea A Polgreen, Philip M Polgreen
Background and Objectives. Hepatorenal syndrome carries a high risk of mortality. Understanding the incidence and mortality trends in hepatorenal syndrome will help inform future studies regarding the safety and efficacy of potential therapeutic interventions. Design and Methods. We conducted a retrospective cohort study using the Nationwide Inpatient Sample. We identified hospitalizations from January 1998-June 2011 with a primary diagnosis of hepatorenal syndrome. To characterize the incidence trends in monthly hepatorenal syndrome hospitalizations, we fit a piecewise linear model with a change point at January 2008...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/27042350/matrix-metalloproteinases-and-subclinical-atherosclerosis-in-chronic-kidney-disease-a-systematic-review
#18
REVIEW
Andreas Kousios, Panayiotis Kouis, Andrie G Panayiotou
Background. Cardiovascular disease (CVD) remains a significant problem in Chronic Kidney Disease (CKD). Subclinical atherosclerosis identified by noninvasive methods could improve CVD risk prediction in CKD but these methods are often unavailable. We therefore systematically reviewed whether circulating levels of Matrix Metalloproteinases (MMPs) and tissue inhibitors (TIMPs) are associated with subclinical atherosclerosis in CKD, as this would support their use as biomarkers or pharmacologic targets. Methods...
2016: International Journal of Nephrology
https://www.readbyqxmd.com/read/26783458/renal-damage-frequency-in-patients-with-solitary-kidney-and-factors-that-affect-progression
#19
T Basturk, Y Koc, Z Ucar, T Sakaci, E Ahbap, E Kara, F Bayraktar, M Sevinc, T Sahutoglu, A Kayalar, A Sinangil, C Akgol, A Unsal
Background. The aim of this study is to assess renal damage incidence in patients with solitary kidney and to detect factors associated with progression. Methods. Medical records of 75 patients with solitary kidney were investigated retrospectively and divided into two groups: unilateral nephrectomy (group 1) and unilateral renal agenesis/dysplasia (group 2). According to the presence of kidney damage, each group was divided into two subgroups: group 1a/b and group 2a/b. Results. Patients in group 1 were older than those in group 2 (p = 0...
2015: International Journal of Nephrology
https://www.readbyqxmd.com/read/26600951/cost-utility-analysis-of-mycophenolate-mofetil-versus-azathioprine-based-regimens-for-maintenance-therapy-of-proliferative-lupus-nephritis
#20
Robert Nee, Ian Rivera, Dustin J Little, Christina M Yuan, Kevin C Abbott
Background/Aims. We aimed to examine the cost-effectiveness of mycophenolate mofetil (MMF) and azathioprine (AZA) as maintenance therapy for patients with Class III and Class IV lupus nephritis (LN), from a United States (US) perspective. Methods. Using a Markov model, we conducted a cost-utility analysis from a societal perspective over a lifetime horizon. The modeled population comprised patients with proliferative LN who received maintenance therapy with MMF (2 gm/day) versus AZA (150 mg/day) for 3 years...
2015: International Journal of Nephrology
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