journal
MENU ▼
Read by QxMD icon Read
search

International Journal of Nephrology

journal
https://www.readbyqxmd.com/read/29977619/transforming-growth-factor-%C3%AE-protects-against-inflammation-related-atherosclerosis-in-south-african-ckd-patients
#1
Muzamil Olamide Hassan, Raquel Duarte, Therese Dix-Peek, Caroline Dickens, Sagren Naidoo, Ahmed Vachiat, Sacha Grinter, Pravin Manga, Saraladevi Naicker
Background: Transforming growth factor- β (TGF- β ) may inhibit the development of atherosclerosis. We evaluated serum levels of TGF- β isoforms concurrently with serum levels of endotoxin and various inflammatory markers. In addition, we determined if any association exists between polymorphisms in the TGF-β1 gene and atherosclerosis in South African CKD patients. Methods: We studied 120 CKD patients and 40 healthy controls. Serum TGF- β 1, TGF- β 2, TGF- β 3, endotoxin, and inflammatory markers were measured...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29977618/microalbuminuria-and-retinopathy-among-hypertensive-nondiabetic-patients-at-a-large-public-outpatient-clinic-in-southwestern-uganda
#2
Peter Kangwagye, Joselyn Rwebembera, Tony Wilson, Francis Bajunirwe
Background: Routine testing of microalbuminuria and retinopathy is not done among patients with high blood pressure in resource-limited settings. We determined the prevalence of microalbuminuria and retinopathy and their risk factors among hypertensive patients at a large hospital in western Uganda. Methods: We consecutively recruited nondiabetic patients with hypertension at the outpatients' clinic over a period of 3 months. Spot urine samples were tested for urine albumin...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29951315/molecular-mechanisms-underlying-accelerated-aging-by-defects-in-the-fgf23-klotho-system
#3
REVIEW
Makoto Kuro-O
The basic research of aging has been primarily focused on elucidating mechanisms of aging and longevity that are evolutionarily conserved from yeasts to primates. Such efforts have culminated in the notion that (1) senescence at the cellular level is associated with aging at the organismal level and that (2) calorie restriction and growth suppression decelerate aging. However, these important findings in the basic research have not necessarily been linked to improvement of daily medical practice in the aging society...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29888004/association-of-poor-social-support-and-financial-insecurity-with-psychological-distress-of-chronic-kidney-disease-patients-attending-national-nephrology-unit-in-sri-lanka
#4
Ramya Hettiarachchi, Chrishantha Abeysena
Background: Chronic kidney disease (CKD) is associated with high morbidity and mortality. Hence, CKD patients are often in chronic psychological distress. The objective of the study was to describe factors associated with psychological distress of CKD patients attending National Nephrology Unit. Methods: A descriptive cross-sectional study was conducted among 382 CKD patients above 18 years of age applying systematic sampling. The data was collected using self-administered questionnaires to assess the psychological distress (GHQ-12), social support (SSQ6), coping strategies (BRIEFCOPE), pain (0 to 10 numeric pain rating scale), and physical role limitation due to ill health (SF36QOL)...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29862077/estimating-renal-function-in-the-elderly-malaysian-patients-attending-medical-outpatient-clinic-a-comparison-between-creatinine-based-and-cystatin-c-based-equations
#5
Maisarah Jalalonmuhali, Salma Mohamed Abouzriba Elagel, Maw Pin Tan, Soo Kun Lim, Kok Peng Ng
Background: To assess the performance of different GFR estimating equations, test the diagnostic value of serum cystatin-C, and compare the applicability of cystatin-C based equation with serum creatinine based equation for estimating GFR (eGFR) in comparison with measured GFR in the elderly Malaysian patients. Methods: A cross-sectional study recruiting volunteered patients 65 years and older attending medical outpatient clinic. 51 chromium EDTA (51 Cr-EDTA) was used as measured GFR...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29854459/undiagnosed-kidney-injury-in-uninsured-and-underinsured-diabetic-african-american-men-and-putative-role-of-meprin-metalloproteases-in-diabetic-nephropathy
#6
Lei Cao, Rashin Sedighi, Ava Boston, Lakmini Premadasa, Jamilla Pinder, George E Crawford, Olugbemiga E Jegede, Scott H Harrison, Robert H Newman, Elimelda Moige Ongeri
Diabetes is the leading cause of chronic kidney disease. African Americans are disproportionately burdened by diabetic kidney disease (DKD) and end stage renal disease (ESRD). Disparities in DKD have genetic and socioeconomic components, yet its prevalence in African Americans is not adequately studied. The current study used multiple biomarkers of DKD to evaluate undiagnosed DKD in uninsured and underinsured African American men in Greensboro, North Carolina. Participants consisted of three groups: nondiabetic controls, diabetic patients without known kidney disease, and diabetic patients with diagnosed DKD...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29854458/contrast-induced-nephropathy-update-on-the-use-of-crystalloids-and-pharmacological-measures
#7
REVIEW
D Patschan, I Buschmann, O Ritter
Contrast-induced nephropathy (CIN) is a frequent and severe complication in subjects receiving iodinated contrast media for diagnostic or therapeutic purposes. Several preventive strategies were evaluated in the past. Recent clinical studies and meta-analyses delivered some new aspects on preventive measures used in the past and present. We will discuss all pharmacological and nonpharmacological procedures. Finally, we will suggest individualized recommendations for CIN prevention.
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29850246/phosphate-and-cardiovascular-disease-beyond-chronic-kidney-disease-and-vascular-calcification
#8
REVIEW
Sinee Disthabanchong
Phosphate is essential for life but its accumulation can be detrimental. In end-stage renal disease, widespread vascular calcification occurs as a result of chronic phosphate load. The accumulation of phosphate is likely to occur long before the rise in serum phosphate above the normal range since several observational studies in both general population and early-stage CKD patients have identified the relationship between high-normal serum phosphate and adverse cardiovascular outcomes. Consumption of food high in phosphate increases both fasting and postprandial serum phosphate and habitual intake of high phosphate diet is associated with aging, cardiac hypertrophy, endothelial dysfunction, and subclinical atherosclerosis...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29692934/a-web-based-platform-to-collect-data-from-esrd-patients-undergoing-dialysis-methods-and-preliminary-results-from-the-brazilian-dialysis-registry
#9
Jocemir R Lugon, Pedro A Gordan, Fernando S Thomé, Antonio A Lopes, Yoshimi J A Watanabe, Carmen Tzanno, Ricardo C Sesso
Introduction: The methods and initial results of a web-based platform to collect data from patients receiving maintenance dialysis in Brazil are reported. Methods: Companies providing management software for dialysis centers adapted their system to comply with a formulary of the Brazilian Society of Nephrology. Baseline and follow-up individual patients' data were transmitted via Internet on monthly bases to the coordinating center from 2011 to 2017. Results: 73 dialysis centers provided information of 24,930 patients: 57% were male, 28% were 64 years old or older, and 13% were overweight/obese...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29692933/murine-nephrotoxic-nephritis-as-a-model-of-chronic-kidney-disease
#10
M K E Ougaard, P H Kvist, H E Jensen, C Hess, I Rune, H Søndergaard
Using the nonaccelerated murine nephrotoxic nephritis (NTN) as a model of chronic kidney disease (CKD) could provide an easily inducible model that enables a rapid test of treatments. Originally, the NTN model was developed as an acute model of glomerulonephritis, but in this study we evaluate the model as a CKD model and compare CD1 and C57BL/6 female and male mice. CD1 mice have previously showed an increased susceptibility to CKD in other CKD models. NTN was induced by injecting nephrotoxic serum (NTS) and evaluated by CKD parameters including albuminuria, glomerular filtration rate (GFR), mesangial expansion, and renal fibrosis...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29682347/prevalence-of-microalbuminuria-in-adult-patients-with-sickle-cell-disease-in-eastern-saudi-arabia
#11
Ahmed M Alkhunaizi, Adil A Al-Khatti, Mansour A Alkhunaizi
Background: Proteinuria is a common feature of sickle cell nephropathy (SCN) that can progress to renal insufficiency and end stage renal disease. Microalbuminuria (MA) is the earliest manifestation of SCN and precedes the development of overt proteinuria. In addition to the renal consequences, MA is linked to cardiovascular complications. Periodic screening and early detection of MA allow early intervention that may reduce the risk of progression to advanced renal failure and cardiovascular diseases...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29682346/restless-legs-syndrome-in-dialysis-patients-does-the-dialysis-modality-influence-its-occurrence-and-severity
#12
Andreia Freire de Menezes, Douglas Rafanelle Moura de Santana Motta, Fernanda Oliveira de Carvalho, Eduesley Santana-Santos, Manoel Pacheco de Andrade Júnior, Mirela Farias Figueirôa, Maria Isabel Teles Farias, Kleyton de Andrade Bastos
Background: Restless legs syndrome (RLS) is more prevalent in chronic kidney patients than in the general population, but it is often diagnosed late and its predictors are unknown. Purpose: To diagnose RLS in a group of chronic kidney patients on dialysis, determine its frequency and severity, compare the prevalence and severity of the condition among dialytic modalities, and identify possible predictive factors in this population. Methods: An observational and cross-sectional study with 326 patients who had been on dialysis for more than 3 months, 241 on hemodialysis (HD) and 85 on automatic peritoneal dialysis (APD), using the criteria established by the International Study Group on RLS for the diagnosis and the RLS Rating Scale to determine its severity...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29552359/low-rather-than-high-body-mass-index-is-a-risk-factor-for-acute-kidney-injury-in-multiethnic-asian-patients-a-retrospective-observational-study
#13
Allen Yan Lun Liu, Jiexun Wang, Milind Nikam, Boon Cheok Lai, Lee Ying Yeoh
Background: Acute kidney injury (AKI) is common in hospitalised patients. The relationship between body mass index (BMI) and the risk of having AKI for patients in the acute hospital setting is not known, particularly in the Asian population. Methods: This was a retrospective, single-centre, observational study conducted in Singapore, a multiethnic population. All patients aged ≥21 years and hospitalised from January to December 2013 were recruited. Results: A total of 12,555 patients were eligible for the analysis...
2018: International Journal of Nephrology
https://www.readbyqxmd.com/read/29403663/cancer-in-anca-associated-glomerulonephritis-a-registry-based-cohort-study
#14
Sanjeevan Sriskandarajah, Leif Bostad, Tor Åge Myklebust, Bjørn Møller, Steinar Skrede, Rune Bjørneklett
Background: Immunosuppressive therapy for antineutrophil cytoplasmic antibody-associated vasculitis has been associated with increased malignancy risk. Objectives: To quantify the cancer risk associated with contemporary cyclophosphamide-sparing protocols. Methods: Patients from the Norwegian Kidney Biopsy Registry between 1988 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody (ANCA) serology were included...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/29333295/serial-galactose-deficient-iga1-levels-in-children-with-iga-nephropathy-and-healthy-controls
#15
John T Sanders, M Colleen Hastings, Zina Moldoveanu, Jan Novak, Bruce A Julian, Zoran Bursac, Robert J Wyatt
Galactose-deficient IgA1 (Gd-IgA1) is a key pathogenic factor for IgA nephropathy (IgAN) and a potential biomarker for the disease. This study examined serial serum Gd-IgA1 levels over 1 year in 13 children with IgAN and 40 healthy children, to determine whether or not serum Gd-IgA1 levels changed over time. Subjects were younger than 18 years of age. Follow-up measurements were scheduled 6 and/or 12 months later. Analysis of variance and regression models for repeated measures were used to estimate group and time effects...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/29225970/dialysis-provision-and-implications-of-health-economics-on-peritoneal-dialysis-utilization-a-review-from-a-malaysian-perspective
#16
REVIEW
Mohd Rizal Abdul Manaf, Naren Kumar Surendra, Abdul Halim Abdul Gafor, Lai Seong Hooi, Sunita Bavanandan
End-stage renal disease (ESRD) is managed by either lifesaving hemodialysis (HD) and peritoneal dialysis (PD) or a kidney transplant. In Malaysia, the prevalence of dialysis-treated ESRD patients has shown an exponential growth from 504 per million population (pmp) in 2005 to 1155 pmp in 2014. There were 1046 pmp patients on HD and 109 pmp patients on PD in 2014. Kidney transplants are limited due to lack of donors. Malaysia adopts public-private financing model for dialysis. Majority of HD patients were treated in the private sector but almost all PD patients were treated in government facilities...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/29201463/complex-monitoring-of-biochemical-and-radionuclide-parameters-in-patients-with-metastatic-renal-cell-carcinoma-during-immunotherapy
#17
M S Sayapina, S G Averinova, T V Zacharova, A V Kashkadaeva, S V Shiryaev, M V Poluectova, O A Vorob'eva
Study Objective: To study the effectiveness of complex monitoring of the kidney function, based on biochemical and radionuclide methods in patients with metastatic renal cell carcinoma (mRCC). Materials and Methods: 41 mRCC patients after nephrectomy received nivolumab ( n = 23) and interferon- α ( n = 18) from 2015 to 2017. At baseline and 2 months after, all patients underwent blood chemistry, urinalysis, Rehberg test, and ELISA to determine serum levels of IL-17A, TGF- β , and erythropoietin...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/29075534/nt-probnp-cardiometabolic-risk-factors-and-nutritional-status-in-hemodialysis-patients
#18
Jacques Ducros, Laurent Larifla, Henri Merault, Lydia Foucan
BACKGROUND: We aimed to evaluate the association between NT-proBNP and malnutrition in HD patients while taking into account the four established categories of parameters for diagnosis of protein energy wasting (PEW). METHODS: A cross-sectional study was performed in Afro-Caribbean dialysis patients. One component in each of the 4 categories for the wasting syndrome was retained: serum albumin ≤ 38 g/L, BMI ≤ 23 Kg/m2 , serum creatinine ≤ 818  µ mol/L, and normalized protein catabolic rate (nPCR) ≤ 0...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28932601/the-role-of-sodium-bicarbonate-in-the-management-of-some-toxic-ingestions
#19
REVIEW
Aibek E Mirrakhimov, Taha Ayach, Aram Barbaryan, Goutham Talari, Romil Chadha, Adam Gray
Adverse reactions to commonly prescribed medications and to substances of abuse may result in severe toxicity associated with increased morbidity and mortality. According to the Center for Disease Control, in 2013, at least 2113 human fatalities attributed to poisonings occurred in the United States of America. In this article, we review the data regarding the impact of systemic sodium bicarbonate administration in the management of certain poisonings including sodium channel blocker toxicities, salicylate overdose, and ingestion of some toxic alcohols and in various pharmacological toxicities...
2017: International Journal of Nephrology
https://www.readbyqxmd.com/read/28912972/denosumab-for-male-hemodialysis-patients-with-low-bone-mineral-density-a-case-control-study
#20
Hiroya Takami, Kazunori Washio, Hiromichi Gotoh
Denosumab increases bone mineral density (BMD) in patients not receiving hemodialysis therapy. However, limited data are available in the literature concerning the use of denosumab in hemodialysis patients. We treated male hemodialysis patients with low radius BMD with denosumab therapy for 1 year and evaluated its effect on radius BMD. Seventeen patients were treated with denosumab 60 mg every 6 months, and 20 patients were not treated with denosumab (control group). At seven days, the mean corrected calcium level decreased from 9...
2017: International Journal of Nephrology
journal
journal
43325
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"