journal
MENU ▼
Read by QxMD icon Read
search

Biochemistry Research International

journal
https://www.readbyqxmd.com/read/29686903/streptozotocin-induced-adaptive-modification-of-mitochondrial-supercomplexes-in-liver-of-wistar-rats-and-the-protective-effect-of-moringa-oleifera-lam
#1
María Alejandra Sánchez-Muñoz, Mónica Andrea Valdez-Solana, Mara Ibeth Campos-Almazán, Óscar Flores-Herrera, Mercedes Esparza-Perusquía, Sofia Olvera-Sánchez, Guadalupe García-Arenas, Claudia Avitia-Domínguez, Alfredo Téllez-Valencia, Erick Sierra-Campos
The increasing prevalence of diabetes continues to be a major health issue worldwide. Alteration of mitochondrial electron transport chain is a recognized hallmark of the diabetic-associated decline in liver bioenergetics; however, the molecular events involved are only poorly understood. Moringa oleifera is used for the treatment of diabetes. However, its role on mitochondrial functionality is not yet established. This study was aimed to evaluate the effect of M. oleifera extract on supercomplex formation, ATPase activity, ROS production, GSH levels, lipid peroxidation, and protein carbonylation...
2018: Biochemistry Research International
https://www.readbyqxmd.com/read/29487749/assessment-of-salivary-adipokines-resistin-visfatin-and-ghrelin-as-type-2-diabetes-mellitus-biomarkers
#2
Mythily Srinivasan, Melinda L Meadows, Lisa Maxwell
Type 2 diabetes mellitus (T2DM) is emerging as a metabolic epidemic worldwide. Pathologically, dysregulation of many biological pathways precedes hyperglycemia and the clinical diagnosis of T2DM. Changing trajectories along the process of T2DM development necessitates frequent measurement of biomarkers for early identification of at-risk individuals and successful prevention. Increase in circulating inflammatory adipokines has been suggested as predictive of T2DM. Human saliva is an easily accessible biospecimen amenable for painless frequent collection and possesses nearly 50% of serum proteome...
2018: Biochemistry Research International
https://www.readbyqxmd.com/read/29387488/genistein-exposure-interferes-with-pharmacokinetics-of-celecoxib-in-sd-male-rats-by-uplc-ms-ms
#3
Xiang Zheng, Jian Wen, Teng-Hui Liu, Qiu-Geng Ou-Yang, Jian-Ping Cai, Hong-Yu Zhou
Objective: To discuss the effects of genistein on the metabolism of celecoxib in vitro and in vivo. Method: In vitro, the effects of genistein on the metabolism of celecoxib were studied using rat and human liver microsomes. In vivo, pharmacokinetics of celecoxib was evaluated in rats with or without genistein. Fifteen Sprague-Dawley (SD) rats were randomized into three groups: celecoxib (A group), celecoxib and 50 mg/kg genistein (B group), and celecoxib and 100 mg/kg genistein (C group)...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/29225971/biochemical-analysis-of-histone-succinylation
#4
Atsushi Yokoyama, Shogo Katsura, Akira Sugawara
Posttranslational modification (PTM) of proteins is used to regulate protein activity and stability. Histone PTMs are regarded as some of the most important, as they can directly regulate gene expression through chromatin reorganization. Recently, histone proteins were found to undergo succinylation, adding to other well-known PTMs such as acetylation, methylation, and phosphorylation. However, there is little information regarding the enzyme which catalyzes histone lysine succinylation. In fact, it is unclear whether this reaction is enzymatic...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/29158919/antioxidant-and-antiradical-properties-of-selected-flavonoids-and-phenolic-compounds
#5
Zübeyir Huyut, Şükrü Beydemir, İlhami Gülçin
Phenolic compounds and flavonoids are known by their antioxidant properties and one of the most important sources for humans is the diet. Due to the harmful effects of synthetic antioxidants such as BHA and BHT, natural novel antioxidants have become the focus of attention for protecting foods and beverages and reducing oxidative stress in vivo . In the current study, we investigated the total antioxidant, metal chelating, Fe3+ and Cu2+ reduction, and free radical scavenging activities of some phenolic and flavonoid compounds including malvin, oenin, ID-8, silychristin, callistephin, pelargonin, 3,4-dihydroxy-5-methoxybenzoic acid, 2,4,6-trihydroxybenzaldehyde, and arachidonoyl dopamine...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/29123924/-in-vitro-evaluation-of-essential-oils-derived-from-piper-nigrum-piperaceae-and-citrus-limonum-rutaceae-against-the-tick-rhipicephalus-boophilus-microplus-acari-ixodidae
#6
Rafaelle Vinturelle, Camila Mattos, Jéssica Meloni, Jeane Nogueira, Maria Júlia Nunes, Itabajara S Vaz, Leandro Rocha, Viviane Lione, Helena C Castro, Evelize Folly das Chagas
The present research aimed to study the chemical composition and acaricidal activity of Citrus limonum and Piper nigrum essential oils against the cattle tick Rhipicephalus microplus . GC-MS analysis of C. limonum essential oil showed limonene (50.3%), β -pinene (14.4%), and γ -terpinene (11.7%) as the major components; P. nigrum oil was mainly composed of β -caryophyllene (26.2%), σ -ocymene (5.8%), and α -pinene (5.5%). Acaricide activity was evaluated at concentrations of 2.5, 5.0, and 10.0% (v/v) of each plant oil, as well as 1 : 1 combination of both oils (5% : 5%, 2...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28932603/the-protective-effect-of-naringenin-oxime-on-cisplatin-induced-toxicity-in-rats
#7
Ismail Koyuncu, Abdurrahim Kocyigit, Ataman Gonel, Erkan Arslan, Mustafa Durgun
The aim of this study is to examine the protective effect of naringenin-oxime (NOX) on cisplatin-induced major organ toxicity and DNA damage in rats. Thirty-five male Wistar albino rats were equally split into five groups as follows: control (i.p., 0.1 ml of saline), Cis administration (i.p., 7 mg/kg b.w.), NOX treatment (i.p., 20 mg/kg b.w., daily for ten days), Cis + NOX20, and Cis + NOX40 combination (i.p., 20 and 40 mg/kg b.w., daily for ten days). Serum and peripheral blood mononuclear leukocytes (PBMC) were obtained from blood...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28932602/serum-transthyretin-level-as-a-plausible-marker-for-diagnosis-of-child-acute-malnutrition
#8
Behailu Tsegaye, Amha Mekasha, Solomon Genet
Malnutrition is a major underlying condition for mortality in children under five years of age in developing countries, particularly in Ethiopia. The most important forms of malnutrition in Ethiopia are protein and energy deficiencies. There is no reliable laboratory method at present to assess acute malnutrition. Transthyretin is a homotetrameric serum protein with half-life of two days. The main objective of this study was to assess the estimation of serum transthyretin level as a useful diagnostic method to evaluate nutritional status of children...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28713593/synthesis-and-evaluation-of-in-vitro-antibacterial-and-antitumor-activities-of-novel-n-n-disubstituted-schiff-bases
#9
Heng Luo, Yu-Fen Xia, Bao-Fei Sun, Li-Rong Huang, Xing-Hui Wang, Hua-Yong Lou, Xu-Hui Zhu, Wei-Dong Pan, Xiao-Dong Zhang
To get inside the properties of N,N-disubstituted Schiff bases, we synthesized three high-yielding benzaldehyde Schiff bases. We used the reaction between salicylaldehyde and different diamine compounds, including diamine, ethanediamine, and o-phenylenediamine, determining the structure of obtained molecules by nuclear magnetic resonance spectroscopy and electrospray ionization mass spectroscopy. We thus evaluated the microbicidal and antitumor activity of these compounds, showing that salicylaldehyde-hydrazine hydrate Schiff base (compound 1a) significantly inhibited the growth of S...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28540087/elevated-cardiovascular-risks-among-postmenopausal-women-a-community-based-case-control-study-from-nepal
#10
Bashu Dev Pardhe, Sumitra Ghimire, Jyotsna Shakya, Sabala Pathak, Shreena Shakya, Anjeela Bhetwal, Puspa Raj Khanal, Narayan Prasad Parajuli
Cardiovascular disease (CVD) is one of the leading causes of death worldwide which is more prevalent in women after menopause. Hormonal changes associated with menopause are accountable for dyslipidemic pattern that causes CVD and associated complications. Therefore, the present study was commenced to compare the lipid profile in pre- and postmenopausal women. A descriptive cross-sectional study was conducted at Manmohan Memorial Institute of Health Sciences (MMIHS) from February 2016 to July 2016. A total of 260 fasting samples were collected from healthy women, 130 from premenopausal and 130 from postmenopausal women, and analyzed for Total Cholesterol (TC), Triacylglycerol (TAG), High Density Lipoprotein Cholesterol (HDL-C), and Low Density Lipoprotein Cholesterol (LDL-C) as per the guideline provided by the reagent manufacturer (Human, Germany)...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28529803/biochemical-content-of-cambium-of-abies-nephrolepis-eaten-by-bears-on-the-far-east-of-russia
#11
I V Seryodkin, A M Zakharenko, P S Dmitrenok, K S Golokhvast
The peculiarity of bears behavior of stripping of bark is typical for all species. We have described the damage to trees, by Asiatic black bear (Ursus thibetanus) and brown bear (U. arctos) in Primorsky Krai and by brown bears on the Sakhalin Island during 1998-2015. In this study, we studied the damaged bark of the tree only in cases where it was clear that part of the cambium was eaten by bears. Cambium of species Abies nephrolepis is the most preferred for bear consumption in Primorsky Krai. We distinguished very large seasonal fluctuations in the amount of its consumption...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28321337/salivary-distinctiveness-and-modifications-in-males-with-diabetes-and-beh%C3%A3-et-s-disease
#12
Loai Aljerf, Iyad Alhaffar
Oral diseases associated with systematic diseases as metabolic and vasculitic have been included in this paper. This will enhance our understanding of the salivary function in promoting healthy oral condition. The study investigates the effects of type I and type II diabetes mellitus in well-controlled diabetic patients, in addition to Behçet disease (BD) on saliva flow rate (SFR), pH, the decay, missing, and filled tooth (DMFT) index, glucose, and major earth-alkaline ions (Ca(2+) and Mg(2+)) compared to healthy males and age-matched controls...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28261501/protective-effect-of-edaravone-against-carbon-monoxide-induced-apoptosis-in-rat-primary-cultured-astrocytes
#13
Xiaodan Xu, Hong Zhang, Ke Wang, Tao Tu, Yuan Jiang
Objective. To observe the protective effect of edaravone (Eda) on astrocytes after prolonged exposure to carbon monoxide (CO) and further to investigate the potential mechanisms of Eda against CO-induced apoptosis. Methods. The rat primary cultured astrocytes were cultured in vitro and exposed to 1% CO for 24 h after being cultured with different concentrations of Eda. MTT assay was used to detect the cytotoxicity of CO. Flow cytometry was used to detect the apoptosis rate, membrane potential of mitochondria, and ROS level...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28168055/in-vitro-and-in-vivo-effects-of-norathyriol-and-mangiferin-on-%C3%AE-glucosidase
#14
Zhi-Long Shi, Yi-Dan Liu, Yun-Yun Yuan, Da Song, Mei-Feng Qi, Xu-Juan Yang, Ping Wang, Xiao-Ying Li, Jian-Hua Shang, Zhao-Xiang Yang
Norathyriol is a metabolite of mangiferin. Mangiferin has been reported to inhibit α-glucosidase. To the best of our knowledge, no study has been conducted to determine or compare those two compounds on inhibiting α-glucosidase in vitro and in vivo by far. In this study, we determined the inhibitory activity of norathyriol and mangiferin on α-glucosidase in vitro and evaluated their antidiabetic effect in diabetic mice. The results showed that norathyriol inhibited α-glucosidase in a noncompetitive manner with an IC50 value of 3...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28044107/molecular-evolution-of-the-glycosyltransferase-6-gene-family-in-primates
#15
Eliane Evanovich, Patricia Jeanne de Souza Mendonça-Mattos, Maria Lúcia Harada
Glycosyltransferase 6 gene family includes ABO, Ggta1, iGb3S, and GBGT1 genes and by three putative genes restricted to mammals, GT6m6, GTm6, and GT6m7, only the latter is found in primates. GT6 genes may encode functional and nonfunctional proteins. Ggta1 and GBGT1 genes, for instance, are pseudogenes in catarrhine primates, while iGb3S gene is only inactive in human, bonobo, and chimpanzee. Even inactivated, these genes tend to be conversed in primates. As some of the GT6 genes are related to the susceptibility or resistance to parasites, we investigated (i) the selective pressure on the GT6 paralogs genes in primates; (ii) the basis of the conservation of iGb3S in human, chimpanzee, and bonobo; and (iii) the functional potential of the GBGT1 and GT6m7 in catarrhines...
2016: Biochemistry Research International
https://www.readbyqxmd.com/read/27656296/crystal-structures-of-two-isozymes-of-citrate-synthase-from-sulfolobus-tokodaii-strain-7
#16
Midori Murakami, Tsutomu Kouyama
Thermoacidophilic archaeon Sulfolobus tokodaii strain 7 has two citrate synthase genes (ST1805-CS and ST0587-CS) in the genome with 45% sequence identity. Because they exhibit similar optimal temperatures of catalytic activity and thermal inactivation profiles, we performed structural comparisons between these isozymes to elucidate adaptation mechanisms to high temperatures in thermophilic CSs. The crystal structures of ST1805-CS and ST0587-CS were determined at 2.0 Å and 2.7 Å resolutions, respectively...
2016: Biochemistry Research International
https://www.readbyqxmd.com/read/27635261/presynaptic-proteins-as-markers-of-the-neurotoxic-activity-of-bmjetx-i-and-bmjetx-ii-toxins-from-bothrops-marajoensis-maraj%C3%A3-lancehead-snake-venom
#17
Antonio Lisboa, Rodolfo Melaré, Junia R B Franco, Carolina V Bis, Marta Gracia, Luis A Ponce-Soto, Sérgio Marangoni, Léa Rodrigues-Simioni, Maria Alice da Cruz-Höfling, Thalita Rocha
Neuromuscular preparations exposed to B. marajoensis venom show increases in the frequency of miniature end-plate potentials and twitch tension facilitation followed by presynaptic neuromuscular paralysis, without evidences of muscle damage. Considering that presynaptic toxins interfere into the machinery involved in neurotransmitter release (synaptophysin, synaptobrevin, and SNAP25 proteins), the main objective of this communication is to analyze, by immunofluorescence and western blotting, the expression of the synaptic proteins, synaptophysin, synaptobrevin, and SNAP25 and by myography, light, and transmission electron microscopy the pathology of motor nerve terminals and skeletal muscle fibres of chick biventer cervicis preparations (CBC) exposed in vitro to BmjeTX-I and BmjeTX-II toxins from B...
2016: Biochemistry Research International
https://www.readbyqxmd.com/read/27493802/urinary-markers-of-tubular-injury-in-hiv-infected-patients
#18
REVIEW
Temesgen Fiseha, Angesom Gebreweld
Renal disease is a common complication of HIV-infected patients, associated with increased risk of cardiovascular events, progression to AIDS, AIDS-defining illness, and mortality. Early and accurate identification of renal disease is therefore crucial to improve patient outcomes. The use of serum creatinine, along with proteinuria, to detect renal involvement is essentially to screen for markers of glomerular disease and may not be effective in detecting earlier stages of renal injury. Therefore, more sensitive and specific markers are needed in order to early identify HIV-infected patients at risk of renal disease...
2016: Biochemistry Research International
https://www.readbyqxmd.com/read/27446613/a-bioinformatics-analysis-reveals-a-group-of-mocr-bacterial-transcriptional-regulators-linked-to-a-family-of-genes-coding-for-membrane-proteins
#19
Teresa Milano, Sebastiana Angelaccio, Angela Tramonti, Martino Luigi Di Salvo, Roberto Contestabile, Stefano Pascarella
The MocR bacterial transcriptional regulators are characterized by an N-terminal domain, 60 residues long on average, possessing the winged-helix-turn-helix (wHTH) architecture responsible for DNA recognition and binding, linked to a large C-terminal domain (350 residues on average) that is homologous to fold type-I pyridoxal 5'-phosphate (PLP) dependent enzymes like aspartate aminotransferase (AAT). These regulators are involved in the expression of genes taking part in several metabolic pathways directly or indirectly connected to PLP chemistry, many of which are still uncharacterized...
2016: Biochemistry Research International
https://www.readbyqxmd.com/read/27429807/potential-properties-of-plant-sprout-extracts-on-amyloid-%C3%AE
#20
Mizue Okada, Yoshinori Okada
The aim of this study is to examine the amyloid β (Aβ) inhibition mechanism of plant sprouts' aqueous extracts (PSAE). In this study, we screened the effects of five plant sprouts' extracts on Aβ (1-42) structure modification using gel electrophoresis. In PSAE, no band of Aβ monomer was recognized in Japanese butterbur. Similarly, the Aβ monomer band became light in buckwheat, red cabbage, broccoli, and brussels. The neuroprotective effects of PSAE were evaluated by measuring levels of Aβ in mixtures (Aβ  and PSAE) with Aβ ELISA assay...
2016: Biochemistry Research International
journal
journal
43323
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"