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Autoimmune Diseases

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https://www.readbyqxmd.com/read/27800178/the-prevalence-of-s-aureus-skin-and-soft-tissue-infections-in-patients-with-pemphigus
#1
Zeinab Fagheei Aghmiyuni, Ahmad Khorshidi, Rezvan Moniri, Tahereh Soori, Seyed Gholam Abbas Musavi
Pemphigus vulgaris are autoimmune blistering diseases that may result in significant morbidity and death. Immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. The aim of this study was to assess the prevalence of S. aureus infection and PVL gene in patients with pemphigus admitted to dermatology clinic. Materials and Methods. This descriptive study was conducted on 196 pemphigus vulgaris patients (119 males, 77 females) admitted to dermatology clinic between 2014 and 2015...
2016: Autoimmune Diseases
https://www.readbyqxmd.com/read/27559482/-18-f-fluoro-deoxy-glucose-positron-emission-tomography-scan-should-be-obtained-early-in-cases-of-autoimmune-encephalitis
#2
C R Newey, A Sarwal, S Hantus
Introduction. Autoimmune encephalitis (AE) is a clinically challenging diagnosis with nonspecific neurological symptoms. Prompt diagnosis is important and often relies on neuroimaging. We present a case series of AE highlighting the importance of an early [(18)F]-fluoro-deoxy-glucose positron emission tomography (FDG-PET) scan. Methods. Retrospective review of seven consecutive cases of autoimmune encephalitis. Results. All patients had both magnetic resonance imaging (MRI) and FDG-PET scans. Initial clinical presentations included altered mental status and/or new onset seizures...
2016: Autoimmune Diseases
https://www.readbyqxmd.com/read/27069677/correlation-of-serum-soluble-interleukin-7-receptor-and-anti-c1q-antibody-in-patients-with-systemic-lupus-erythematosus
#3
Shuhong Chi, Jing Xue, Feng Li, Caixia Zhu, Yunxia Yu, Haibo Li, Xuemei Wang, Yurong Zhang, Jijuan Yang, Shaolan Zhou, Lijuan Yang, Chen Ji, Xiaoming Liu
Background. Serum concentrations of soluble interleukin-7 receptor (sIL-7R) and anti-C1q antibody have recently been identified as unique serological markers for lupus nephritis (LN) in patients with systemic lupus erythematosus (SLE). In this study, we evaluated the correlation of serum sIL-7R and anti-C1q in SLE patients. Methods. Sera from 134 patients with SLE and 84 healthy cohorts were tested for levels of sIL-7R and anti-C1q antibodies in terms of ELISA. Correlations of the sIL-7R and anti-C1q autoantibodies were evaluated...
2016: Autoimmune Diseases
https://www.readbyqxmd.com/read/27034824/increased-circulating-th17-cells-serum-il-17a-and-il-23-in-takayasu-arteritis
#4
Durga Prasanna Misra, Smriti Chaurasia, Ramnath Misra
Introduction. Th17, γδT, NK, and NKT cells in peripheral blood and serum IL-17 and IL-23 in Takayasu arteritis (TA) were measured and correlated with disease activity. Methods. Th17 (anti-CD3APC, CD4PECy7, and IL-17PE), NKT, NK (anti-CD3APC, CD56FITC), and γδT (anti-CD3FITC and γδTCRAPC) cells were enumerated by flow cytometry in peripheral blood of 30 patients with TA (ACR1990 criteria) and 20 healthy controls, serum IL-17 and IL-23 measured by ELISA. Relation with disease activity (NIH criteria, ITAS2010) was analyzed (using nonparametric tests, median with interquartile range)...
2016: Autoimmune Diseases
https://www.readbyqxmd.com/read/26989506/mechanism-of-xinfeng-capsule-on-adjuvant-induced-arthritis-via-analysis-of-urinary-metabolomic-profiles
#5
Hui Jiang, Jian Liu, Ting Wang, Jia-Rong Gao, Yue Sun, Chuan-Bing Huang, Mei Meng, Xiu-Juan Qin
We aimed to explore the potential effects of Xinfeng capsule (XFC) on urine metabolic profiling in adjuvant-induced arthritis (AA) rats by using gas chromatography time-of-flight mass spectrometry (GC-TOF/MS). GC-TOF/MS technology was combined with multivariate statistical approaches, such as principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), and orthogonal projections to latent structures discriminant analysis (OPLS-DA). These methods were used to distinguish the healthy group, untreated group, and XFC treated group and elucidate potential biomarkers...
2016: Autoimmune Diseases
https://www.readbyqxmd.com/read/26925260/prooxidant-antioxidant-balance-in-patients-with-systemic-lupus-erythematosus-and-its-relationship-with-clinical-and-laboratory-findings
#6
Seyyed Mehdi Jafari, Saeedeh Salimi, Alireza Nakhaee, Hamed Kalani, Shima Tavallaie, Farzaneh Farajian-Mashhadi, Zahra Zakeri, Mahnaz Sandoughi
Aim. This study was aimed at evaluating prooxidant-antioxidant balance (PAB) in patients with systemic lupus erythematosus (SLE) and its relationship with laboratory findings and clinical manifestations. Methods. In this case-control study, 60 patients with SLE and 60 healthy individuals were enrolled. The blood samples were collected and their sera were separated. Subsequently, the prooxidant-antioxidant balance value was evaluated using PAB assay for each sample. Results. The mean of PAB values in SLE patients was significantly higher than healthy controls (147...
2016: Autoimmune Diseases
https://www.readbyqxmd.com/read/26885383/risk-factors-and-adverse-events-poorly-predict-infections-and-hypogammaglobulinemia-in-granulomatosis-with-polyangiitis-patients-receiving-rituximab
#7
Emilio Besada
Background. 29 GPA patients from the Northern Norway vasculitis disease registry received rituximab (RTX) induction and maintenance. 24% and 31% had, respectively, severe and chronic infections while 45% had hypogammaglobulinemia and 28% discontinued RTX due to hypogammaglobulinemia. The aim of the study was to examine how known predictors and adverse events interacted with adverse events using structural statistical methods. Methods. Five predictors (age, cyclophosphamide, total Ig and CD4/CD8 ratio prior RTX, and type of RTX maintenance regimen) and 4 adverse events (severe and chronic infections, hypogammaglobulinemia, and RTX discontinuation) were modeled in principal component and redundancy analyses...
2016: Autoimmune Diseases
https://www.readbyqxmd.com/read/26613049/pentraxin-3-plasma-levels-and-disease-activity-in-systemic-lupus-erythematosus
#8
Roberto Assandri, Marta Monari, Anna Colombo, Alessandra Dossi, Alessandro Montanelli
SLE is an autoimmune disorder that involves polyclonal autoimmunity against multiple autoantigens. PTX3, a marker of the acute-phase inflammatory response, plays an important role in innate immunity and in modulation of the adaptive immune response. Our study tried to resolve some rather controversial aspects of the use of PTX3 as a biomarker of disease activity in SLE patients. We demonstrated that plasma PTX3 concentration of the SLE patients was significantly higher than the healthy control groups and reflected disease activity...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26457200/the-attenuated-live-yellow-fever-virus-17d-infects-the-thymus-and-induces-thymic-transcriptional-modifications-of-immunomodulatory-genes-in-c57bl-6-and-balb-c-mice
#9
Breno Luiz Melo-Lima, Danillo Lucas Alves Espósito, Benedito Antônio Lopes da Fonseca, Luiz Tadeu Moraes Figueiredo, Philippe Moreau, Eduardo Antonio Donadi
Thymus is involved in induction of self-tolerance in T lymphocytes, particularly due to Aire activity. In peripheral tissues, Treg cells and immunomodulatory molecules, like the major histocompatibility complex (MHC) class Ib molecules, are essential for maintenance of autotolerance during immune responses. Viral infections can trigger autoimmunity and modify thymic function, and YFV17D immunization has been associated with the onset of autoimmunity, being contraindicated in patients with thymic disorders. Aiming to study the influence of YFV17D immunization on the transcriptional profiles of immunomodulatory genes in thymus, we evaluated the gene expression of AIRE, FOXP3, H2-Q7 (Qa-2/HLA-G), H2-T23 (Qa-1/HLA-E), H2-Q10, and H2-K1 following immunization with 10,000 LD50 of YFV17D in C57BL/6 and BALB/c mice...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26457199/immunological-parameters-associated-with-vitiligo-treatments-a-literature-review-based-on-clinical-studies
#10
REVIEW
Ana Cláudia Guimarães Abreu, Gabriela Guy Duarte, Juliana Yasmin Pains Miranda, Daniel Gontijo Ramos, Camila Gontijo Ramos, Mariana Gontijo Ramos
Vitiligo, a depigmentary disorder, caused by the loss of melanocytes, affects approximately 1% of the world population, irrespective of skin type, with a serious psychological impact on the patient quality of life. So far, the origin of vitiligo has not been traced and the pathogenesis is complex, involving the interplay of a multitude of variables. Although there is no treatment that ensures the complete cure of the disorder, there are some pharmacological, phototherapy, and surgical therapies available. A series of variables can affect treatment outcome, such as individual characteristics, emotional issues, type of vitiligo, stability of the lesions, and immunological status...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26442157/association-of-ifn-%C3%AE-%C3%A2-%C3%A2-il-10-cytokine-ratio-with-nonsegmental-vitiligo-pathogenesis
#11
Yaswanth Ala, Mohammed Khalid Pasha, Raja Narasimha Rao, Prasanna Latha Komaravalli, Parveen Jahan
Background and Objectives. Cytokines regulate immune response and inflammation and play a crucial role in depigmentation process of vitiligo. The present study aimed to estimate the serum levels of pro- and anti-inflammatory cytokines, IFN-γ and IL-10, and their ratios in nonsegmental vitiligo patients and healthy individuals from India. Methods. Blood samples were collected from 280 subjects and serum IFN-γ and IL-10 levels were measured using standard ELISA. Results. Nonsegmental vitiligo patients showed increased levels of IFN-γ (12...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26442156/social-support-and-self-reported-stress-levels-in-a-predominantly-african-american-sample-of-women-with-systemic-lupus-erythematosus
#12
Edith Marie Williams, Jiajia Zhang, Judith Anderson, Larisa Bruner, Laurene Tumiel-Berhalter
Lupus patients should avoid stress because physical or emotional stress can affect overall physical health. It has been suggested that social support has a positive influence on health status, but there is a lack of information in the literature on the association between the two among lupus patients. The current study investigated the association between social support and self-reported stress and coping status among African American women with lupus using data collected from two linked cross-sectional surveys...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26421184/hepatic-but-not-cns-expressed-human-c-reactive-protein-inhibits-experimental-autoimmune-encephalomyelitis-in-transgenic-mice
#13
Tyler T Wright, Rachel V Jimenez, Todd E Morgan, Namrata Bali, Xiaogang Hou, Mark A McCrory, Caleb E Finch, Alexander J Szalai
We recently demonstrated that human C-reactive protein (CRP), expressed hepatically in transgenic mice (CRPtg), improved the outcome of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The liver is the primary site of CRP synthesis in humans and in CRPtg mice but is also expressed by both at low levels in the CNS. To determine if CNS expression of human CRP is sufficient to impact EAE, we generated neuronal CRP transgenic mice (nCRPtg) wherein human CRP expression is driven by the neuron-specific Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα) gene promoter...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26290755/detection-of-antibodies-against-human-and-plant-aquaporins-in-patients-with-multiple-sclerosis
#14
Aristo Vojdani, Partha Sarathi Mukherjee, Joshua Berookhim, Datis Kharrazian
Multiple sclerosis (MS) is an autoimmune disease that affects the body's central nervous system. Around 90% of MS sufferers are diagnosed with relapsing-remitting MS (RRMS). We used ELISA to measure IgG, IgA, and IgM antibodies against linear epitopes of human and plant aquaporins (AQP4) as well as neural antigens in RRMS patients and controls to determine whether patients suffering from RRMS have simultaneous elevations in antibodies against these peptides and antigens. In comparison to controls, significant elevations in isotype-specific antibodies against human and plant AQP4 and neural antigens such as MBP, MOG, and S100B were detected in RRMS patients, indicating a high correlation in antibody reaction between plant aquaporins and brain antigens...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26273477/therapeutic-effect-of-saponin-rich-fraction-of-achyranthes-aspera-linn-on-adjuvant-induced-arthritis-in-sprague-dawley-rats
#15
Pankaj S Kothavade, Vipin D Bulani, Dnyaneshwar M Nagmoti, Padmini S Deshpande, Nitin B Gawali, Archana R Juvekar
Objective. Achyranthes aspera Linn. (AA) is used in folklore for the treatment of various inflammatory ailments and arthritis like conditions. Anti-inflammatory activity of saponin rich (SR) fraction of AA has been previously reported. The objective of this study was to assess the antiarthritic effect of SR fraction of Achyranthes aspera in adjuvant-induced arthritic rats. Methods. Arthritis was assessed by arthritis score, paw volume, changes in tibiotarsal joint thickness, hyperalgesic parameters, and spleen and thymus index...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26246906/urine-monocyte-chemoattractant-protein-1-and-lupus-nephritis-disease-activity-preliminary-report-of-a-prospective-longitudinal-study
#16
Sabah Alharazy, Norella C T Kong, Marlyn Mohd, Shamsul A Shah, Arbaiyah Ba'in, Abdul Halim Abdul Gafor
Objective. This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers. Methods. Patients with LN-active or inactive-had their uMCP-1 levels and standard disease activity markers measured at baseline and 2 and 4 months. Urinary parameters, renal function test, serological markers, and renal SLE disease activity index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uMCP-1...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26246905/understanding-and-managing-pregnancy-in-patients-with-lupus
#17
REVIEW
Guilherme Ramires de Jesus, Claudia Mendoza-Pinto, Nilson Ramires de Jesus, Flávia Cunha Dos Santos, Evandro Mendes Klumb, Mario García Carrasco, Roger Abramino Levy
Systemic lupus erythematosus (SLE) is a chronic, multisystemic autoimmune disease that occurs predominantly in women of fertile age. The association of SLE and pregnancy, mainly with active disease and especially with nephritis, has poorer pregnancy outcomes, with increased frequency of preeclampsia, fetal loss, prematurity, growth restriction, and newborns small for gestational age. Therefore, SLE pregnancies are considered high risk condition, should be monitored frequently during pregnancy and delivery should occur in a controlled setting...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26246904/association-between-secondary-and-primary-sj%C3%A3-gren-s-syndrome-in-a-large-collection-of-lupus-families
#18
Rachna Aggarwal, Juan-Manuel Anaya, Kristi A Koelsch, Biji T Kurien, R Hal Scofield
Objective. Systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26240757/predisposition-to-cervical-atypia-in-systemic-lupus-erythematosus-a-clinical-and-cytopathological-study
#19
Hend Hilal Al-Sherbeni, Ahmed Mohamed Fahmy, Nadine Sherif
Introduction. Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course, and prognosis. The female genital tract may be a potential target organ in SLE since cervical inflammation may be associated with disease activity. An increase in cervical dysplasia, a precursor of cervical cancer, has been reported in females with SLE. Aim of the Work. This work aimed to study the prevalence of abnormal cervicovaginal smears in patients with systemic lupus erythematosus (SLE) and to correlate abnormal smear findings with exposure to infection with human papilloma virus (HPV) in SLE patients...
2015: Autoimmune Diseases
https://www.readbyqxmd.com/read/26236499/pathophysiological-relationship-between-infections-and-systemic-vasculitis
#20
REVIEW
Carolina Muñoz-Grajales, Juan C Pineda
The development of autoimmune disorders requires a combination of genetic, immunological, and environmental factors. Infectious agents, such as viruses and bacteria, can trigger autoimmunity through different mechanisms, and for systemic vasculitis in particular, microbial agents have been suggested to be involved in its pathogenesis. Although the exact mechanisms have not been fully elucidated, different theories have been postulated. This review considers the role of infections in the etiology of primary vasculitis, emphasizing their related immunological events...
2015: Autoimmune Diseases
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