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Frontiers in Psychiatry

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https://www.readbyqxmd.com/read/28428761/effect-of-case-management-interventions-for-patients-with-substance-use-disorders-a-systematic-review
#1
REVIEW
Louise Penzenstadler, Ariella Machado, Gabriel Thorens, Daniele Zullino, Yasser Khazaal
BACKGROUND: Substance use disorder (SUD) is an important health problem that requires a complex range of care because of the chronic nature of the disorder and the multiple psychosocial problems involved. Current outpatient programs often have difficulties in delivering and coordinating ongoing care and access to different health-care providers. Various case management (CM) models have been developed, first for patients in other psychiatric domains and then for patients with SUD, in order to improve treatment outcomes...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28421005/autoimmune-aspects-of-neurodegenerative-and-psychiatric-diseases-a-template-for-innovative-therapy
#2
REVIEW
Peter de Haan, Hans C Klein, Bert A 't Hart
Neurodegenerative and psychiatric diseases (NPDs) are today's most important group of diseases, surpassing both atherosclerotic cardiovascular disease and cancer in morbidity incidence. Although NPDs have a dramatic impact on our society because of their high incidence, mortality, and severe debilitating character, remarkably few effective interventions have become available. The current treatments, if available, comprise the lifelong intake of general immunosuppressants to delay disease progression or neurotransmitter antagonists/agonists to dampen undesired behaviors...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28405189/corrigendum-brief-report-a-preference-for-biological-motion-predicts-a-reduction-in-symptom-severity-1%C3%A2-year-later-in-preschoolers-with-autism-spectrum-disorders
#3
Martina Franchini, Hillary Wood de Wilde, Bronwyn Glaser, Edouard Gentaz, Stephan Eliez, Marie Schaer
[This corrects the article on p. 143 in vol. 7, PMID: 27605914.].
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28400737/reduced-resting-state-functional-connectivity-in-current-and-recovered-restrictive-anorexia-nervosa
#4
Jessica Clare Scaife, Lauren Rose Godier, Nicola Filippini, Catherine J Harmer, Rebecca J Park
Functional connectivity studies based on resting-state functional magnetic resonance imaging (rs-fMRI) have shown alterations in brain networks associated with self-referential processing, cognitive control, and somatosensory processing in anorexia nervosa (AN). This study aimed to further investigate the functional connectivity of resting-state networks (RSNs) in homogenous subsamples of individuals with restrictive AN (current and recovered) and the relationship this has with core eating disorder psychopathology...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28396642/editorial-mental-imagery-in-clinical-disorders
#5
EDITORIAL
David G Pearson, Julie Krans
No abstract text is available yet for this article.
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28396641/editorial-eyeblink-classical-conditioning-in-psychiatric-conditions-novel-uses-for-a-classic-paradigm
#6
EDITORIAL
Tracy L Greer, Lucien T Thompson
No abstract text is available yet for this article.
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28396640/vitamin-d-deficiency-as-a-potential-environmental-risk-factor-in-multiple-sclerosis-schizophrenia-and-autism
#7
REVIEW
Eva Kočovská, Fiona Gaughran, Amir Krivoy, Ute-Christiane Meier
In this short review, we want to summarize the current findings on the role of vitamin-D in multiple sclerosis (MS), schizophrenia, and autism. Many studies have highlighted hypovitaminosis-D as a potential environmental risk factor for a variety of conditions such as MS, asthma, cardiovascular disease, and, more recently, psychiatric diseases. However, whether hypovitaminosis-D is a potential causative factor for the development or activity in these conditions or whether hypovitaminosis-D may be due to increased vitamin-D consumption by an activated immune system (reverse causation) is the focus of intense research...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28373849/deep-brain-stimulation-in-anorexia-nervosa-hope-for-the-hopeless-or-exploitation-of-the-vulnerable-the-oxford-neuroethics-gold-standard-framework
#8
Rebecca J Park, Ilina Singh, Alexandra C Pike, Jacinta O A Tan
Neurosurgical interventions for psychiatric disorders have a long and troubled history (1, 2) but have become much more refined in the last few decades due to the rapid development of neuroimaging and robotic technologies (2). These advances have enabled the design of less invasive techniques, which are more focused, such as deep brain stimulation (DBS) (3). DBS involves electrode insertion into specific neural targets implicated in pathological behavior, which are then repeatedly stimulated at adjustable frequencies...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28373848/the-current-status-of-the-ketogenic-diet-in-psychiatry
#9
REVIEW
Emmanuelle C S Bostock, Kenneth C Kirkby, Bruce V M Taylor
BACKGROUND: The ketogenic diet (KD) has been used in treatment-resistant epilepsy since the 1920s. It has been researched in a variety of neurological conditions in both animal models and human trials. The aim of this review is to clarify the potential role of KD in psychiatry. METHODS: Narrative review of electronic databases PubMED, PsychINFO, and Scopus. RESULTS: The search yielded 15 studies that related the use of KD in mental disorders including anxiety, depression, bipolar disorder, schizophrenia, autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28373847/t-cell-deficits-and-overexpression-of-hepatocyte-growth-factor-in-anti-inflammatory-circulating-monocytes-of-middle-aged-patients-with-bipolar-disorder-characterized-by-a-high-prevalence-of-the-metabolic-syndrome
#10
Rogier J Vogels, Manja A Koenders, Elisabeth F C van Rossum, Annet T Spijker, Hemmo A Drexhage
BACKGROUND: We previously reported T cell deficits and pro-inflammatory gene activation in circulating monocytes of two cohorts of bipolar disorder (BD) patients, a cohort of postpartum psychosis patients and in bipolar offspring. Pro-inflammatory gene activation occurred in two clusters of mutually correlating genes, cluster 1 for inflammation-related cytokines/factors, cluster 2 for motility, chemotaxis, and metabolic factors. AIM: To verify these cellular immune abnormalities in yet another cohort [the bipolar stress study (BiSS) cohort] of relative old (52 years, median) BD patients and to relate immune abnormalities to hair cortisol levels, measured in this cohort and representing long-term systemic cortisol levels, and to the presence of the metabolic syndrome (MetS), which was prevalent in 29% of the BiSS patients...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28373846/depression-outcomes-in-adults-attending-family-practice-were-not-improved-by-screening-stepped-care-or-online-cbt-during-a-12-week-study-when-compared-to-controls-in-a-randomized-trial
#11
Peter H Silverstone, Katherine Rittenbach, Victoria Y M Suen, Andreia Moretzsohn, Ivor Cribben, Marni Bercov, Andrea Allen, Catherine Pryce, Deena M Hamza, Michael Trew
There is uncertainty regarding possible benefits of screening for depression in family practice, as well as the most effective treatment approach when depression is identified. Here, we examined whether screening patients for depression in primary care, and then treating them with different modalities, was better than treatment-as-usual (TAU) alone. Screening was carried out for depression using the 9-item Patient Health Questionnaire (PHQ-9), with a score of ≥10 indicating significant depressive symptoms...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28367128/the-role-of-norepinephrine-and-its-%C3%AE-adrenergic-receptors-in-the-pathophysiology-and-treatment-of-major-depressive-disorder-and-schizophrenia-a-systematic-review
#12
REVIEW
Vladimir Maletic, Anna Eramo, Keva Gwin, Steve J Offord, Ruth A Duffy
Norepinephrine (NE) is recognized as having a key role in the pathophysiology of major depressive disorder (MDD) and schizophrenia, although its distinct actions via α-adrenergic receptors (α-ARs) are not well defined. We performed a systematic review examining the roles of NE and α-ARs in MDD and schizophrenia. PubMed and ProQuest database searches were performed to identify English language papers published between 2008 and 2015. In total, 2,427 publications (PubMed, n = 669; ProQuest, n = 1,758) were identified...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28367127/alterations-of-intrinsic-brain-connectivity-patterns-in-depression-and-bipolar-disorders-a-critical-assessment-of-magnetoencephalography-based-evidence
#13
REVIEW
Golnoush Alamian, Ana-Sofía Hincapié, Etienne Combrisson, Thomas Thiery, Véronique Martel, Dmitrii Althukov, Karim Jerbi
Despite being the object of a thriving field of clinical research, the investigation of intrinsic brain network alterations in psychiatric illnesses is still in its early days. Because the pathological alterations are predominantly probed using functional magnetic resonance imaging (fMRI), many questions about the electrophysiological bases of resting-state alterations in psychiatric disorders, particularly among mood disorder patients, remain unanswered. Alongside important research using electroencephalography (EEG), the specific recent contributions and future promise of magnetoencephalography (MEG) in this field are not fully recognized and valued...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28360866/from-toxoplasmosis-to-schizophrenia-via-nmda-dysfunction-peptide-overlap-between-toxoplasma-gondii-and-n-methyl-d-aspartate-receptors-as-a-potential-mechanistic-link
#14
Guglielmo Lucchese
The present work aims at investigating how Toxoplasma gondii (T. gondii) infection may be linked to N-methyl-d-aspartate receptor (NMDAR) dysfunction in schizophrenia and related disorders and puts forward the hypothesis that immune responses against T. gondii may involve NMDARs. Indeed, the analysis of the protozoan proteome and NMDAR subunits for peptide commonalities shows a massive peptide overlap and supports the possibility that anti-T. gondii immune responses raised during active protozoan infection may cross-react with host NMDARs, determining disruption of neural circuits and cognitive deficits...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28352237/reduced-freezing-in-posttraumatic-stress-disorder-patients-while-watching-affective-pictures
#15
Iro Fragkaki, Karin Roelofs, John Stins, Ruud A Jongedijk, Muriel A Hagenaars
Besides fight and flight responses, animals and humans may respond to threat with freezing, a response characterized by bradycardia and physical immobility. Risk assessment is proposed to be enhanced during freezing to promote optimal decision making. Indeed, healthy participants showed freezing-like responses to threat cues. Posttraumatic stress disorder (PTSD) patients are characterized by hypervigilance and increased threat responsiveness. We propose that threat responses will be characterized by decreased freezing in PTSD, eliminating possibilities for rejecting cognitive distortions, such as harm expectancy, and thereby contributing to the maintenance of the disorder...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28348533/clinical-characteristics-of-diabetes-mellitus-and-suicide-risk
#16
REVIEW
Chiara Conti, Chiara Mennitto, Giulia Di Francesco, Federica Fraticelli, Ester Vitacolonna, Mario Fulcheri
BACKGROUND: Diabetes mellitus (DM) is a chronic illness with impaired health-related quality of life and a high risk of psychiatric disorders. We carried out a systematic review analyzing the relationship between DM and suicide by providing a qualitative data synthesis of the studies. METHODS: We conducted, in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search of the literature in PubMed, Scopus, ISI Web of Science, PsycINFO, Google Scholar, and ScienceDirect...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28348532/ethical-implications-of-the-mild-encephalitis-hypothesis-of-schizophrenia
#17
Rita Riedmüller, Sabine Müller
Schizophrenia is a serious mental disease with a high mortality rate and severe social consequences. Due to insufficient knowledge about its etiopathogenesis, curative treatments are not available. One of the most promising new research concepts is the mild encephalitis hypothesis of schizophrenia, developed mainly by Karl Bechter and Norbert Müller. According to this hypothesis, a significant subgroup of schizophrenia patients suffer from a mild, but chronic, form of encephalitis with markedly different etiologies ranging from viral infections, traumas to autoimmune diseases...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28344562/attachment-styles-and-suicide-related-behaviors-in-adolescence-the-mediating-role-of-self-criticism-and-dependency
#18
Giorgio Falgares, Daniela Marchetti, Sandro De Santis, Danilo Carrozzino, Daniel C Kopala-Sibley, Mario Fulcheri, Maria Cristina Verrocchio
Insecure attachment and the personality dimensions of self-criticism and dependency have been proposed as risk factors for suicide in adolescents. The present study examines whether self-criticism and dependency mediate the relationship between insecure attachment styles and suicidality. A sample of 340 high-school students (73.2% females), ranging in age from 13 to 20 years (M = 16.47, SD = 1.52), completed the Depressive Experiences Questionnaire for Adolescents, the Depressive Experiences Questionnaire for Adolescents, the Attachment Style Questionnaire, and the Suicidal Behaviors Questionnaire-Revised...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28337154/the-reciprocal-relationship-between-suicidality-and-stigma
#19
REVIEW
Bernardo Carpiniello, Federica Pinna
INTRODUCTION: Although suicidality is frequently the cause of stigma, it is conversely true that stigma may be the cause of suicidality. The present paper focuses on the complex relationships that exist between suicidal behavior and stigmatizing attitudes. METHODS: A narrative review of the topic will be presented on the basis of the relevant literature collected from an electronic search of PubMed, ISI Web of Knowledge, and Scopus databases, using stigma, public stigma, structural stigma, perceived stigma, self-stigma, suicide, attempted suicide, and suicidality as key words...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28321193/early-psychosis-and-trauma-related-disorders-clinical-practice-guidelines-and-future-directions
#20
Casey A Cragin, Martha B Straus, Dawn Blacker, Laura M Tully, Tara A Niendam
Despite high rates of trauma-related disorders among individuals with early psychosis, no clinical practice guidelines for the treatment of comorbid early psychosis and trauma-related disorders exist to date. Indeed, the routine exclusion of individuals with past and current psychosis from participation in trauma research and practice has limited the accumulation of research that could support such clinical practice guidelines. While preliminary research evidence suggests that traditional, evidence-based treatments for trauma-related disorders can be safely and effectively employed to reduce symptoms of posttraumatic stress and chronic psychosis, it remains unclear whether such treatments are appropriate for individuals in the early stages of psychotic illness...
2017: Frontiers in Psychiatry
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