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Therapeutic Hypothermia and Temperature Management

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https://www.readbyqxmd.com/read/28520548/intracoronary-hypothermia-before-reperfusion-to-reduce-reperfusion-injury-in-acute-myocardial-infarction-a-novel-hypothesis-and-technique
#1
Luuk C Otterspoor, Lokien X van Nunen, Marcel van 't Veer, Nils P Johnson, Nico H J Pijls
Because current reperfusion strategies in acute myocardial infarction (AMI) seem to be exhausted in terms of additional mortality benefit, there remains a need for new methods to attenuate reperfusion injury and, thereby, further reduce myocardial infarct size and improve long-term survival. Therapeutic hypothermia (32-35°C) diminishes reperfusion injury and reduces infarct size in a variety of animal models of AMI if provided before reperfusion. In human studies this reduction has not been confirmed so far, most likely because systemic cooling acts slowly, and therefore, the target temperature is not reached in time or at all in a substantial number of patients...
May 18, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28467285/hypothalamic-or-extrahypothalamic-modulation-and-targeted-temperature-management-after-brain-injury
#2
Rishabh Charan Choudhary, Xiaofeng Jia
Targeted temperature management (TTM) has been recognized to protect tissue function and positively influence neurological outcomes after brain injury. While shivering during hypothermia nullifies the beneficial effect of TTM, traditionally, antishivering drugs or paralyzing agents have been used to reduce the shivering. The hypothalamic area of the brain helps in controlling cerebral temperature and body temperature through interactions between different brain areas. Thus, modulation of different brain areas either pharmacologically or by electrical stimulation may contribute in TTM; although, very few studies have shown that TTM might be achieved by activation and inhibition of neurons in the hypothalamic region...
May 3, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28445087/cardioprotection-by-mild-hypothermia-is-abolished-in-aged-mice
#3
Junjie Guo, Shuning Zhang, Leilei Ma, Hongtao Shi, Jianbing Zhu, Jian Wu, Yi An, Junbo Ge
Mild hypothermia (MH) renders the hearts resistant to ischemia/reperfusion (IR) injury in animal experiments. Unexpectedly, this effect was not observed in recent clinical trials. The aged hearts in mice have been demonstrated to be more susceptible to IR injury. This study aimed to examine whether the cardioprotection of MH was abolished in aged mice. Young (Y, 3 months old) and aged (A, 20 months old) male C57BL/6 mice were randomized into six groups. Sham (Y-SHAM and A-SHAM) and control (Y-CON+IR and A-CON+IR) animals maintained core body temperature at 37°C ± 0...
April 26, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28418788/factors-associated-with-delayed-cooling-in-cardiac-arrest-patients
#4
David A Pearson, Katherine Mayer, Catherine M Wares, Michael S Runyon, Jonathan R Studnek, Shana L Ward, Kathi M Kraft, Alan C Heffner
Therapeutic hypothermia has been shown to improve neurologic outcome in medical cardiac arrest patients, yet little is known about factors that delay target temperature achievement. Our primary aim was to identify factors associated with not achieving our institutional "door-to-cool" (DTC) performance goal (emergency department [ED] arrival to temperature of 34°C) of ≤4 hours. Secondary aims included whether achievement of DTC goal was associated with timing of bolus neuromuscular blockade (NMB), survival, or functional outcome...
April 18, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28338422/therapeutic-hypothermia-reduces-the-inflammatory-response-following-ischemia-reperfusion-injury-in-rat-hearts
#5
Jianru Shi, Wangde Dai, Robert A Kloner
Therapeutic hypothermia (TH) is known to protect against ischemia/reperfusion (I/R) injury. One mechanism of I/R injury includes secondary injury due to the inflammatory cascade. We hypothesized that TH reduces the inflammatory response following I/R injury. Rats were randomized to sham, normothermic, or hypothermic groups and subjected to 1 hour of coronary artery occlusion and 48 hours of reperfusion. Hypothermia was initiated, using the ThermoSuit(®) device, 2 minutes after the onset of coronary artery occlusion to a core temperature of 32°C, and then the rats were allowed to rewarm...
March 24, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28437237/proteomics-in-hypothermia-as-adjunctive-therapy-in-patients-with-st-segment-elevation-myocardial-infarction-a-chill-mi-substudy
#6
Moman A Mohammad, Marco Noc, Irene Lang, Michael Holzer, Peter Clemmensen, Ulf Jensen, Bernhard Metzler, David Erlinge
Cardiovascular and inflammatory biomarkers in therapeutic hypothermia have been studied in cardiac arrest, but data on patients with ST-segment elevation myocardial infarction (STEMI) treated with therapeutic hypothermia are currently unavailable. A multiplex proximity extension assay allowed us to measure 157 cardiovascular disease (CVD) and inflammatory disease-related biomarkers in patients from the international, multicenter, and randomized trial; CHILL-myocardial infarction (MI) and to explore the associations of cardiovascular and inflammatory biomarkers...
March 2, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28437236/temperature-variation-after-rewarming-from-deep-hypothermic-circulatory-arrest-is-associated-with-survival-and-neurologic-outcome
#7
Alessio Rungatscher, Giovanni Battista Luciani, Daniele Linardi, Elisabetta Milani, Leonardo Gottin, Beat Walpoth, Giuseppe Faggian
Therapeutic hypothermia is recommended by international guidelines after cardio-circulatory arrest. However, the effects of different temperatures during the first 24 hours after deep hypothermic circulatory arrest (DHCA) for aortic arch surgery on survival and neurologic outcome are undefined. We hypothesize that temperature variation after aortic arch surgery is associated with survival and neurologic outcome. In the period 2010-2014, a total of 210 consecutive patients undergoing aortic arch surgery with DHCA were included...
March 1, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28253089/clinical-studies-targeting-stroke-and-ischemic-insults
#8
Justin Lundbye, Patrick D Lyden, Kees H Polderman, Stefan Schwab
No abstract text is available yet for this article.
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28157443/temperature-management-in-the-new-year
#9
W Dalton Dietrich
No abstract text is available yet for this article.
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28117626/clinical-q-a-translating-therapeutic-temperature-management-from-theory-to-practice
#10
Stephen A Figueroa, Mary McKenna Guanci, Patricia A Blissitt, William D Cahoon
No abstract text is available yet for this article.
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28106521/therapeutic-hypothermia-in-postcardiac-arrest
#11
Kees H Polderman, Rajesh Dash, Graham Nichol, Nicolas Deye
No abstract text is available yet for this article.
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28072919/perspectives-on-temperature-management
#12
Graham Nichol, Romer Geocadin, Michael Kurz, Michael Mooney
No abstract text is available yet for this article.
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27875660/successful-use-of-targeted-temperature-management-after-repair-of-myocardial-rupture-from-blunt-chest-trauma-a-case-report
#13
Wook-Jin Choi, Yun Seok Kim, Jung Seok Hong, Jeong Won Kim
Targeted temperature management (TTM) improves survival and neurological outcome after nontraumatic cardiac arrest. However, TTM is not used widely after traumatic cardiac arrest because of concerns that it might exacerbate bleeding. We report the use of postarrest TTM after repair of blunt myocardial rupture. A 48-year-old man was admitted after being rescued from a major traffic accident by the local emergency service. Focused sonography showed pericardial fluid without cardiac tamponade. Computed tomography showed a large hematoma in the anterior mediastinum associated with hemopericardium...
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27835072/the-outcomes-of-targeted-temperature-management-after-cardiac-arrest-at-emergency-department-a-real-world-experience-in-a-developing-country
#14
Winchana Srivilaithon, Sombat Muengtaweepongsa
Targeted temperature management (TTM) is indicated for comatose survivors of cardiac arrest to improve outcomes. However, the benefit of TTM was verified by rigid controlled clinical trials. This study aimed at evaluating its effects in real-world practices. A prospective observational study was done at the emergency department of tertiary care, Thammasat Hospital, from March 2012 until October 2015. We included all who did not obey verbal commands after being resuscitated from cardiac arrest regardless of initial cardiac rhythm...
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27635468/rapid-induction-of-therapeutic-hypothermia-using-transnasal-high-flow-dry-air
#15
Raghuram Chava, Menekhem Zviman, Madhavan Srinivas Raghavan, Henry Halperin, Farhan Maqbool, Romergryko Geocadin, Alfredo Quinones-Hinojosa, Aravindan Kolandaivelu, Benjamin A Rosen, Harikrishna Tandri
Early induction of therapeutic hypothermia (TH) is recommended in out-of-hospital cardiac arrest (CA); however, currently no reliable methods exist to initiate cooling. We investigated the effect of high flow transnasal dry air on brain and body temperatures in adult porcine animals. Adult porcine animals (n = 23) under general anesthesia were subject to high flow of transnasal dry air. Mouth was kept open to create a unidirectional airflow, in through the nostrils and out through the mouth. Brain, internal jugular, and aortic temperatures were recorded...
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27419613/variability-of-post-cardiac-arrest-care-practices-among-cardiac-arrest-centers-united-states-and-south-korean-dual-network-survey-of-emergency-physician-research-principal-investigators
#16
Patrick J Coppler, Kelly N Sawyer, Chun Song Youn, Seung Pill Choi, Kyu Nam Park, Young-Min Kim, Joshua C Reynolds, David F Gaieski, Byung Kook Lee, Joo Suk Oh, Won Young Kim, Hyung Jun Moon, Benjamin S Abella, Jonathan Elmer, Clifton W Callaway, Jon C Rittenberger
There is little consensus regarding many post-cardiac arrest care parameters. Variability in such practices could confound the results and generalizability of post-arrest care research. We sought to characterize the variability in post-cardiac arrest care practice in Korea and the United States. A 54-question survey was sent to investigators participating in one of two research groups in South Korea (Korean Hypothermia Network [KORHN]) and the United States (National Post-Arrest Research Consortium [NPARC])...
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27403966/asian-targeted-temperature-management-task-panel-report
#17
Mayuki Aibiki, Ming-Chou Chiang, Sombat Muengtaweepongsa, Sohil Pothiawala, Chien-Hua Huang
In the fields of emergency and critical care, targeted temperature management has become a critical issue and particularly popular in clinical practices throughout Asia. As more research is carried out, evidence and concepts about targeted temperature management continue to evolve. Areas of interest include new 2015 resuscitation guidelines, temperature management in pediatrics, and integrated care and neurological monitoring for cardiac arrest patients. The Asian Targeted Temperature Management task panel includes colleagues from various Asian countries and allows them to exchange experiences in a professional environment...
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27383062/the-association-between-arterial-oxygen-tension-and-neurological-outcome-after-cardiac-arrest
#18
Nicholas J Johnson, Kalani Dodampahala, Babette Rosselot, Sarah M Perman, Mark E Mikkelsen, Munish Goyal, David F Gaieski, Anne V Grossestreuer
A number of observational studies have evaluated the association between arterial oxygen tensions and outcome after cardiac arrest with variable results. The objective of this study is to determine the association between arterial oxygen tension and neurological outcome after cardiac arrest. A retrospective cohort analysis was performed using the Penn Alliance for Therapeutic Hypothermia registry. Adult patients who experienced return of spontaneous circulation after in-hospital or out-of-hospital cardiac arrest (OHCA) and had a partial pressure of arterial oxygen (PaO2) recorded within 48 hours were included...
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27327871/temperature-control-in-rodent-neuroprotection-studies-methods-and-challenges
#19
Ana C Klahr, Colby A Nadeau, Frederick Colbourne
Extensive animal research facilitated the clinical translation of therapeutic hypothermia for cardiac arrest in adults and hypoxic-ischemic injury in infants. Similarly, clinical interest in hypothermia for other brain injuries, such as stroke, has been greatly supported by positive findings in preclinical work. The reliability, validity, and utility of animal models, among many research practices (blinding, randomization, etc.), are key to successful clinical translation. Here, we review methods used to induce and maintain hypothermia in animal models...
March 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28106522/clinical-studies-targeting-stroke-and-ischemic-insults
#20
Justin Lundbye, Patrick D Lyden, Kees H Polderman, Stefan Schwab
No abstract text is available yet for this article.
January 20, 2017: Therapeutic Hypothermia and Temperature Management
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