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Therapeutic Hypothermia and Temperature Management

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https://www.readbyqxmd.com/read/28731840/clinical-effect-of-rebound-hyperthermia-after-cooling-postcardiac-arrest-a-meta-analysis
#1
Parth Makker, Yumiko Kanei, Deepkia Misra
Rebound hyperthermia (RH) is frequently seen after completion of targeted temperature management (TTM) in comatose survivors of cardiac arrest. However, its clinical significance is not well understood. Previous studies analyzing the association of RH with clinical outcome have reported conflicting results. The purpose of this meta-analysis is to examine the impact of RH after completion of TTM in patients postcardiac arrest. We reviewed six studies that evaluated the incidence of RH (T > 38°C) with documentation of outcome based on the presence of hyperthermia...
July 21, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28708472/rectal-instillation-of-cold-fluids-for-targeted-temperature-management-after-cardiac-arrest-a-case-report
#2
Andrej Markota, Jure Fluher, Andreja Sinkovič
The optimal method of temperature management after cardiac arrest remains unknown. Methods that are most effective are usually invasive and expensive. Noninvasive methods are not as effective and obstruct access to the patient. Temperature management via rectal cooling offers some potential advantages in survivors of cardiac arrest, namely, relatively large volumes of temperature-controlled fluids can be instilled, access to the patient is not obstructed, and fluid overload can be ameliorated by removal of a fraction of instilled fluid...
July 14, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28708464/effect-of-whole-body-hypothermia-on-surfactant-function-when-amniotic-fluid-is-meconium-stained
#3
Chiara Autilio, Mercedes Echaide, Valentina Dell'Orto, Jesus Perez-Gil, Daniele De Luca
We provide the first complete biophysical study of surfactant by captive bubble surfactometry from a neonate with meconium-stained amniotic fluid under controlled whole body hypothermia. Surfactant function improves after 48 hours of hypothermia, as surfactant cholesterol decreases. These findings partially explain positive effect of hypothermia on respiratory outcomes during meconium aspiration syndrome. A larger study including several neonates with or without lung disease is being conducted to better define the effect of hypothermia on surfactant function...
July 14, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28665255/hypothermia-identifies-dynamin-as-a-potential-therapeutic-target-in-experimental-stroke
#4
Jong Youl Kim, Nuri Kim, Jong Eun Lee, Midori A Yenari
Apoptosis is a cell death pathway that is activated in ischemic stroke. The interaction between Fas and its ligand (FasL) initiates a complex pattern of intracellular events involving the recruitment of specific adaptor proteins and the development of apoptosis. We recently reported that dynamin is increased after experimental stroke, and its inhibition improves neurological outcome. Dynamin has been shown to transport Fas from the endoplasmic reticulum to the cell surface where it can be bound by its ligand, FasL...
June 30, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28665234/magnesium-levels-and-neurologic-outcomes-in-patients-undergoing-therapeutic-hypothermia-after-cardiac-arrest
#5
William H Perucki, Brett Hiendlmayr, David M O'Sullivan, Angeline C Gunaseelan, Farruk Fayas, Antonio B Fernandez
Therapeutic hypothermia (TH) improves neurological outcomes after cardiac arrest by mitigating cerebral reperfusion injury. Serum magnesium (Mg) inhibits glutamate release, restores blood-brain barrier integrity, and decreases brain edema. The neuroprotective role of Mg in cardiac arrest patients undergoing TH is not well established. We analyzed 438 survivors of cardiac arrest who completed a TH protocol from 2008 through 2016. Multivariate and receiver operating characteristic (ROC) analyses examined the association between Mg supplementation and Mg levels before, during, and after TH with neurologic outcomes...
June 30, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28570829/therapeutic-hypothermia-for-asphyxial-out-of-hospital-cardiac-arrest-due-to-drowning-a-systematic-review-of-case-series-and-case-reports
#6
Kai-Fung Kevin Suen, Reynold Leung, Ling-Pong Leung
The objective of this review was to summarize published evidence of the effectiveness of therapeutic hypothermia in patients with drowning-associated asphyxial out-of-hospital cardiac arrest (OHCA) and to explore any preliminary favorable factors in the management of therapeutic hypothermia to improve survival and neurological outcome. Drowning may result in asphyxial OHCA or hypothermic OHCA, but the former does not provide any potential neuroprotective effect as the latter may do. Electronic literature searches of Ovid Medline, Embase, Cochrane Library, and Scopus were performed for all years from inception to July 2016...
June 1, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28557694/targeted-temperature-management-effectiveness-in-the-elderly-insights-from-a-large-registry
#7
Timothy J Mader, Lauren M Westafer, Brian H Nathanson, Nadia Villarroel, Ryan A Coute, Bryan F McNally
Targeted temperature management (TTM) is recommended for all comatose adult out-of-hospital cardiac arrest (OHCA) patients with shockable first documented rhythm. However, studies examining the use and benefits of TTM among patients aged 75 and older are lacking. Using the Cardiac Arrest Registry to Enhance Survival (CARES) dataset registry from 2013 to 2015. Study criteria included being 75 years of age or older, survival to hospital admission, and known in-hospital mortality and CPC (Cerebral Performance Categories Scale) Scores...
May 30, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28520548/intracoronary-hypothermia-before-reperfusion-to-reduce-reperfusion-injury-in-acute-myocardial-infarction-a-novel-hypothesis-and-technique
#8
Luuk C Otterspoor, Lokien X van Nunen, Marcel van 't Veer, Nils P Johnson, Nico H J Pijls
Because current reperfusion strategies in acute myocardial infarction (AMI) seem to be exhausted in terms of additional mortality benefit, there remains a need for new methods to attenuate reperfusion injury and, thereby, further reduce myocardial infarct size and improve long-term survival. Therapeutic hypothermia (32-35°C) diminishes reperfusion injury and reduces infarct size in a variety of animal models of AMI if provided before reperfusion. In human studies this reduction has not been confirmed so far, most likely because systemic cooling acts slowly, and therefore, the target temperature is not reached in time or at all in a substantial number of patients...
May 18, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28467285/hypothalamic-or-extrahypothalamic-modulation-and-targeted-temperature-management-after-brain-injury
#9
Rishabh Charan Choudhary, Xiaofeng Jia
Targeted temperature management (TTM) has been recognized to protect tissue function and positively influence neurological outcomes after brain injury. While shivering during hypothermia nullifies the beneficial effect of TTM, traditionally, antishivering drugs or paralyzing agents have been used to reduce the shivering. The hypothalamic area of the brain helps in controlling cerebral temperature and body temperature through interactions between different brain areas. Thus, modulation of different brain areas either pharmacologically or by electrical stimulation may contribute in TTM; although, very few studies have shown that TTM might be achieved by activation and inhibition of neurons in the hypothalamic region...
May 3, 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28617214/clinical-q-a-translating-therapeutic-temperature-management-from-theory-to-practice
#10
William D Cahoon, Stephen A Figueroa, Teresa Wavra, Mary McKenna Guanci, Claranne Mathiesen, Leslie A Hamilton
No abstract text is available yet for this article.
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28586295/temperature-management-in-neurological-and-neurosurgical-intensive-care-unit
#11
Patrick Lyden, Stephan A Mayer, Keith Lurie, Erich Schmutzhard
No abstract text is available yet for this article.
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28561599/intraoperative-temperature-management
#12
Stephan A Mayer, Marlene Fischer, Kees H Polderman, Coleen Atkins
No abstract text is available yet for this article.
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28557636/therapeutic-hypothermia-and-temperature-management
#13
W Dalton Dietrich
No abstract text is available yet for this article.
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28437236/temperature-variation-after-rewarming-from-deep-hypothermic-circulatory-arrest-is-associated-with-survival-and-neurologic-outcome
#14
Alessio Rungatscher, Giovanni Battista Luciani, Daniele Linardi, Elisabetta Milani, Leonardo Gottin, Beat Walpoth, Giuseppe Faggian
Therapeutic hypothermia is recommended by international guidelines after cardio-circulatory arrest. However, the effects of different temperatures during the first 24 hours after deep hypothermic circulatory arrest (DHCA) for aortic arch surgery on survival and neurologic outcome are undefined. We hypothesize that temperature variation after aortic arch surgery is associated with survival and neurologic outcome. In the period 2010-2014, a total of 210 consecutive patients undergoing aortic arch surgery with DHCA were included...
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28418788/factors-associated-with-delayed-cooling-in-cardiac-arrest-patients
#15
David A Pearson, Katherine Mayer, Catherine M Wares, Michael S Runyon, Jonathan R Studnek, Shana L Ward, Kathi M Kraft, Alan C Heffner
Therapeutic hypothermia has been shown to improve neurologic outcome in medical cardiac arrest patients, yet little is known about factors that delay target temperature achievement. Our primary aim was to identify factors associated with not achieving our institutional "door-to-cool" (DTC) performance goal (emergency department [ED] arrival to temperature of 34°C) of ≤4 hours. Secondary aims included whether achievement of DTC goal was associated with timing of bolus neuromuscular blockade (NMB), survival, or functional outcome...
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27982758/burst-suppression-in-hypothermia-after-cardiac-arrest-because-of-drowning-treated-with-targeted-temperature-management-a-case-report
#16
Tomoya Okazaki, Toru Hifumi, Satoshi Egawa, Hideyuki Hamaya, Natsuyo Shinohara, Shohei Kawamoto, Takuma Iwaki, Kohei Tsukahara, Kenya Kawakita, Takashi Kusaka, Yasuhiro Kuroda
Outcomes of cardiac arrest (CA) because of drowning in children are generally poor, but some reports show that cases with post-CA hypothermia because of drowning exhibit good recovery when treated with targeted temperature management (TTM). However, because electroencephalogram (EEG) findings are not reported in those cases, a complete examination of brain damage has not been performed during TTM. Here we report a case of a 15-month-old boy with post-CA hypothermia recovery after treating with TTM, along with EEG findings...
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27860555/time-to-awakening-is-often-delayed-in-patients-who-receive-targeted-temperature-management-after-cardiac-arrest
#17
Katie Zanyk-McLean, Kelly N Sawyer, Ryan Paternoster, Rebekah Shievitz, William Devlin, Robert Swor
Post cardiac arrest, neuroprognostication remains a complex and clinically challenging issue for critical care providers. For this reason, our primary objective in this study was to determine the frequency of survival and favorable neurological outcomes in post-cardiac arrest patients with delayed time to awakening. To assess whether early withdrawal of care may adversely impact survival, we also sought to describe the time to withdrawal of care of non-surviving patients. We performed a retrospective study of patients resuscitated after cardiac arrest in two large academic community hospitals...
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27849437/optimum-temperature-of-oxygen-for-transpulmonary-hypothermia-with-cooled-oxygen-inhalation-a-preliminary-study-in-a-rat-model
#18
Banu Karakus Yilmaz, Hatice Topcu, Yahya A Acar, Duygu Sultan Oran, Sule Ozsoy, Erdem Çevik, Aylin Hakligor, Orhan Çinar
Cooled oxygen inhalation was hypothesized as a novel hypothermia technique in a previous study. In the current study, we aimed to determine the optimal temperature of oxygen for this method. This is a prospective, randomized, controlled, examiner-blinded experimental study conducted with 45 healthy, adult, Wistar Hannover male rats. Rats were randomly divided into five groups; group 1: +4°C intubated group (n = 7), group 2: +4°C nonintubated group (n = 9), group 3: +8°C intubated group (n = 9), group 4: +8°C nonintubated group (n = 9), and group 5: control group (n = 9)...
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27676120/therapeutic-hypothermia-during-neonatal-transport-active-cooling-helps-reach-the-target
#19
Tiffany D Stafford, Joseph L Hagan, Curtis G Sitler, Caraciolo J Fernandes, Jeffrey R Kaiser
Perinatal hypoxic ischemic encephalopathy (HIE) can lead to severe neurodevelopmental outcome and death. Therapeutic hypothermia is neuroprotective for infants with moderate-to-severe HIE. However, therapeutic hypothermia is only offered at high-level regional neonatal intensive care units (NICUs), necessitating the need to transport sick infants to referral centers. The goal of this study was to evaluate whether active cooling on transport is more effective than passive cooling in achieving temperatures in the treatment target range (33°C-34°C) on arrival to the Texas Children's Hospital (TCH) NICU...
June 2017: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/28445087/cardioprotection-by-mild-hypothermia-is-abolished-in-aged-mice
#20
Junjie Guo, Shuning Zhang, Leilei Ma, Hongtao Shi, Jianbing Zhu, Jian Wu, Yi An, Junbo Ge
Mild hypothermia (MH) renders the hearts resistant to ischemia/reperfusion (IR) injury in animal experiments. Unexpectedly, this effect was not observed in recent clinical trials. The aged hearts in mice have been demonstrated to be more susceptible to IR injury. This study aimed to examine whether the cardioprotection of MH was abolished in aged mice. Young (Y, 3 months old) and aged (A, 20 months old) male C57BL/6 mice were randomized into six groups. Sham (Y-SHAM and A-SHAM) and control (Y-CON+IR and A-CON+IR) animals maintained core body temperature at 37°C ± 0...
April 26, 2017: Therapeutic Hypothermia and Temperature Management
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