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Journal of Adolescent and Young Adult Oncology

Andrea C Johnson, Darren Mays, Kathryn Rehberg, Aziza Shad, Kenneth P Tercyak
PURPOSE: Adolescent and young adult (AYA) cancer survivors experience fertility and childrearing challenges in adulthood, but there is limited evidence on awareness, beliefs, and concerns about oncofertility in this population, needs for supportive resources, and associations with quality of life (QoL). METHODS: Participants were 69 AYAs aged 12-25 who were diagnosed with cancer at age 18 years or younger and ≥1 year cancer free, recruited from childhood cancer clinical records and support organizations...
April 19, 2018: Journal of Adolescent and Young Adult Oncology
Judith Fortmann, Abigail Fisher, Rachael Hough, Alice Gregory, Gemma Pugh
PURPOSE: Teenage and young adult (TYA) cancer survivors experience a range of health-related problems during and beyond the active treatment period. This study examined associations between fatigue, sleep quality, and health-related quality of life (HRQOL) among TYA survivors. METHODS: Self-reported data on sleep quality (Pittsburgh Sleep Quality Index), fatigue (Functional Assessment of Chronic Illness Therapy Fatigue), and HRQOL (EuroQoL-5) were gathered from United Kingdom TYA survivors between 13 and 24 years of age...
April 10, 2018: Journal of Adolescent and Young Adult Oncology
Meghan E McGrady, Robin E Norris, Ahna L H Pai
There is a growing interest by both pediatric and medical oncologists to develop adolescent and young adult (AYA)-specific cancer programs. Input from AYA patients is critical to the successful design of these programs and to ensuring that patient needs are met. As traditional in-person advisory groups may not be the most appropriate means for engaging AYAs, this article describes the creation and implementation of a novel, developmentally appropriate, and efficient Young Adult Advisory Program. Reach, uptake, and participant demographic and clinical characteristics are presented alongside lessons learned...
April 10, 2018: Journal of Adolescent and Young Adult Oncology
Kimberly Peeters, Pleuntje Jellema, Margo Annemans, Ann Heylighen
PURPOSE: Adolescence is a transition period involving complex development processes. A life-threatening disease like cancer jeopardizes this development and often exposes adolescents to hospital environments that are unadjusted to them. Despite growing research on how the physical environment affects the well-being of the (child as) patient, adolescents are often overlooked. We investigated how adolescents experience a hospital stay and how the physical environment influences that experience...
March 27, 2018: Journal of Adolescent and Young Adult Oncology
Andrew B Smitherman, Chelsea Anderson, Jennifer L Lund, Jeannette T Bensen, Donald L Rosenstein, Hazel B Nichols
PURPOSE: Cancer survivors are at increased risk for the early development of age-related chronic medical conditions compared with peers without a history of cancer; however, little is known regarding the burden of these conditions among survivors of adolescent and young adult (AYA) cancers. In response, we sought to determine the prevalence of specific comorbidities and frailty among AYAs (15-39 years old at diagnosis) enrolled in a cancer survivorship cohort. METHODS: Using a cross-sectional survey of a tertiary medical center-based cancer survivorship cohort, we determined the prevalence of specific comorbidities and frailty using the survey-based FRAIL assessment...
March 23, 2018: Journal of Adolescent and Young Adult Oncology
Dava Szalda, Marilyn M Schapira, Linda A Jacobs, Steven C Palmer, Carolyn Vachani, James Metz, Christine Hill-Kayser
PURPOSE: Young adult survivors (YAS) of cancer experience late effects of treatment similar to older adult survivors (AS). Online health tools such as Internet-based survivorship care plans (SCPs) can provide access to information about late effects and symptom management, but little is known about SCP patterns of use among YAS. METHODS: An Internet-based cross-sectional survey was completed over 24 months. Participants were individuals diagnosed with cancer between 18 and 39 years (YAS, n = 611) or 40-60 years (AS, n = 1742), who were 2-20 years postdiagnosis, and who created an Internet-based SCP...
March 23, 2018: Journal of Adolescent and Young Adult Oncology
Shoshana R Rath, Treya M Long, Natasha L Bear, Gordon C P Miles, Andrew M Bullock, Nicholas G Gottardo, Catherine H Cole, Louise H Naylor, Catherine S Y Choong
PURPOSE: To assess metabolic function among adolescent and young adult (AYA) survivors of childhood cancer-related brain surgery or cranial irradiation (CRT) and to determine feasibility, safety, and metabolic as well as psychological impact of a 6-month exercise program in this cohort. METHODS: Twenty AYAs aged 15-23 years were recruited. All had completed cancer treatment by age 15.5 and were more than 1 year after end of treatment. Metabolic function was assessed at baseline (T1), after a 6-month non-intervention period (T2), and after the 6-month intervention (T3)...
March 22, 2018: Journal of Adolescent and Young Adult Oncology
Erin E Cook, Annie MacMillan, Susan T Gershman
This brief report describes the burden of cancer among adolescents and young adults (AYAs), aged 15-39 years, in Massachusetts from 2004 to 2014 using data from the Massachusetts Cancer Registry and Registry of Vital Records and Statistics. In Massachusetts, 4.6% of cancer cases and 1.3% of cancer deaths occurred among AYAs. The incidence rate of cancer among AYAs was 77.6 cases per 100,000 and the mortality rate was 8.0 deaths per 100,000. The incidence rates of melanoma and Hodgkin lymphoma have been decreasing annually...
March 22, 2018: Journal of Adolescent and Young Adult Oncology
Samantha C Sodergren, Olga Husson, Gudrun E Rohde, Iwona M Tomasewska, Bella Vivat, Noam Yarom, Helen Griffiths, Anne-Sophie Darlington
PURPOSE: In recent years, the assessment of health-related quality of life (HRQoL) has been recognized as particularly informative to healthcare providers. For adolescents and young adults (AYAs), the impact of a cancer diagnosis and subsequent treatment is likely to be distinct from other age groups given the unique and complex physical and psychosocial challenges of this developmental phase. The objective of this study was to capture the HRQoL issues described by AYAs with cancer using thematic analysis...
March 22, 2018: Journal of Adolescent and Young Adult Oncology
Kaspar Jessen Pedersen, Kirsten Arntz Boisen, Julie Midtgaard, Abbey Elsbernd, Hanne Baekgaard Larsen
PURPOSE: An insufficient transition to normal life after cancer treatment in adolescent and young adults (AYAs) may lead to decreased occupational and educational opportunities throughout a survivor's lifespan. Key informant interviews were used to access unique knowledge of the healthcare, educational, and social systems. METHODS: We used key informant interviews with professionals representing disciplines from healthcare, educational, and social systems (n = 15)...
March 13, 2018: Journal of Adolescent and Young Adult Oncology
Zeynep Canan Özdemir, Yeter Düzenli Kar, Meliha Demiral, Başar Sırmagül, Özcan Bör, Birgül Kırel
PURPOSE: Metabolic syndrome (MetS) and obesity have increasingly been reported in survivors of childhood cancer. Osteopontin (OPN) is primarily synthesized in adipose tissue and is thought to have a role in obesity and the development of insulin resistance (IR). The aim of this study was to investigate the frequency of MetS in survivors of acute lymphoblastic leukemia (ALL) and to establish the relationship between serum OPN levels and anthropometric measurements and glucose metabolism...
March 12, 2018: Journal of Adolescent and Young Adult Oncology
Vicky Lehmann, Leena Nahata, Amanda C Ferrante, Jennifer A Hansen-Moore, Nicholas D Yeager, James L Klosky, Cynthia A Gerhardt
PURPOSE: To present an overview of fertility-related perceptions and describe the perceived negative/positive impact of (potential) infertility on romantic relationships among childhood cancer survivors. METHODS: Male and female long-term childhood cancer survivors (N = 92) aged 22-43 and 7-37 years postdiagnosis, completed an online survey about fertility-related perceptions (i.e., knowledge, beliefs, uncertainty, concern, and attitudes toward testing) and romantic relationships...
February 21, 2018: Journal of Adolescent and Young Adult Oncology
Monica Gupta, Lalita Singhal, Akshay Kumar
Multiple osteolytic lesions are usually associated with metastatic involvement of the bone; however, metabolic bone diseases should also be included in the differential diagnosis. In this study, we describe a case of primary hyperparathyroidism (PHPT) with multiple osteolytic lesions that was diagnosed initially as having metastatic bone involvement. The laboratory results showed hypercalcemia and raised alkaline phosphatase along with fibrosis in the bone marrow biopsy with no increase in tumor markers and normal serum protein electrophoresis...
February 15, 2018: Journal of Adolescent and Young Adult Oncology
Steve Marshall, Anne Grinyer, Mark Limmer
The purpose of this review is to explore the literature on the experience of adolescents and young adults (AYAs) having cancer treatment in an adult setting, rather than on a specialist adolescent cancer unit. The integrative review method was used to explore the current literature. Primary research on the topic was located systematically and then synthesized into a thematic narrative. The experience of AYAs undergoing treatment in an adult setting was generally negative. This can be attributed to three themes: feeling isolated in the adult setting; the lack of empathy from staff working in the adult setting; and the inappropriateness of the adult environment for this age group...
February 13, 2018: Journal of Adolescent and Young Adult Oncology
Cynthia J Bell, Ryan A Bell, Brad Zebrack, Ikuko Kato, Alyssa Morse, Scott C Borinstein
Adolescents and young adults (AYAs) 15-39 years old face unique challenges during cancer treatment as developmental and social needs are often disrupted to achieve cure. Developmentally appropriate supportive care for AYAs across the cancer trajectory is needed. The purpose of this review is to identify and describe instruments that measure AYA development across physical, psychological, and social domains, commenting on the instruments' psychometric properties and usefulness in clinical practice and research...
February 9, 2018: Journal of Adolescent and Young Adult Oncology
Karel de Bree, Anneke M Westermann, Heinz-Josef Klümpen, Joanne Verheij, Saffire S K S Phoa, Matthijs Oomen, Thomas M van Gulik
Adult hepatoblastoma (AHB) is a rare liver tumor with a poor prognosis in adolescents and adults. This contrasts with hepatoblastoma in children and is not fully understood. Here we describe two adolescents with AHB who were treated in our hospital. Adolescents are likely to receive less intensive chemotherapy protocols and are treated in hospitals with less experience in pediatric oncology, resulting in poor outcome. More research is necessary for optimal treatment of AHB in adolescents. Adolescents with AHB should be referred to hospitals experienced in pediatric oncology and receive intensive chemotherapy, followed by hemihepatectomy...
February 7, 2018: Journal of Adolescent and Young Adult Oncology
Akira Kojima, Kazunari Yamada, Koichi Kajiwara, Yuichi Takeuchi, Marina Matsui, Masao Tsukada, Kanichi Iwama, Yasuji Kozai, Hideki Kodo
A novel induction therapy, including intensive L-asparaginase, was designed in 2007 for patients aged <45 years with Philadelphia-negative acute lymphoblastic leukemia (ALL). We analyzed seven de novo cases and one case of recurrence who received this treatment. The median age was 21 years (range: 16-35 years). Four patients had T-ALL and the others had B-ALL. All the patients achieved complete remission and proceeded to cord blood transplantation. In the median 72-month follow-up, there were no cases of observed mortality or recurrence...
February 6, 2018: Journal of Adolescent and Young Adult Oncology
Elaine Wheat Dawson, Karen Clark, Richard Obenchain, Matthew J Loscalzo, Jeanelle Folbrecht
PURPOSE: This study examines biopsychosocial problem-related distress and requests for assistance with male and female young adult patients by applying a large-scale analysis among individuals diagnosed with a variety of cancers. METHODS: A retrospective study was conducted involving 630 patients of ages 18-39 treated for cancer at City of Hope between 2009 and 2014. Patients were asked to complete a biopsychosocial problem-related distress touch-screen instrument before treatment as part of their routine clinical care...
February 2, 2018: Journal of Adolescent and Young Adult Oncology
Maria Olsson, Karin Enskär, Gunnar Steineck, Ulrica Wilderäng, Marianne Jarfelt
OBJECTIVE: Cancer treatment may result in various effects that last long after treatment has been concluded. The purpose of this study was to explore to what extent scars affect adolescents and young adults postcancer treatment. METHODS: In this population-based study, a study-specific questionnaire was developed by a method used in several previous investigations carried out by our research group, Clinical Cancer Epidemiology. Question development involved expert validation by professionals from oncology units, midwives, epidemiologists, and statisticians...
January 26, 2018: Journal of Adolescent and Young Adult Oncology
David M Roder, Allison Warr, Pandora Patterson, Kimberley R Allison
PURPOSE: Cancer is a significant health concern for adolescents and young adults (AYAs; aged 15-24 years). Monitoring population-level changes in incidence, mortality, and survival is complicated by the lack of published data presenting statistics separately for AYAs. This study synthesizes and reviews data on AYA cancers in Australia, including trends in incidence and mortality. METHODS: National data were extracted for 1980-2012, primarily from the Australian Cancer Database and Australian National Mortality Database...
January 26, 2018: Journal of Adolescent and Young Adult Oncology
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