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Journal of Adolescent and Young Adult Oncology

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https://www.readbyqxmd.com/read/30312134/a-survey-study-of-attitude-and-knowledge-regarding-female-fertility-preservation-among-reproductive-health-professionals-in-fujian-china
#1
Ke Ju, Megan Kopp, Yuqing Wang, Gehui Yuan, Weiwei Zheng, Lauren M Ataman, Teresa K Woodruff, Qionghua Chen, Shuo Xiao
PURPOSE: Oncofertility is a newly developed medical field dedicated to preserving adolescent and young adult-aged cancer patients' fertility. For female cancer patients who desire to have children, fertility preservation has become an important concern before the cancer therapy. This study for the first time aimed to investigate attitude and knowledge regarding female fertility preservation among reproductive health professionals in China. METHODS: An online questionnaire assessing participants' demographics, experience, attitude, and basic knowledge regarding oncofertility was designed and distributed to reproductive health professionals in Fujian, one of the major regions for cancer and reproductive care in southeast China...
October 12, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30312117/shifting-needs-and-preferences-supporting-young-adult-cancer-patients-during-the-transition-from-active-treatment-to-survivorship-care
#2
Casey Walsh, Jennifer Currin-McCulloch, Pamela Simon, Brad Zebrack, Barbara Jones
PURPOSE: This study was designed to identify and explore the social support needs and preferences of young adult cancer patients during the transition process from active treatment to survivorship care. METHODS: Semi-structured qualitative interviews were conducted with study participants (n = 13, ages 17-25 at the time of cancer diagnosis) within ∼6 months of completion of active treatment and again 3 months later. Participants completed a sociodemographic questionnaire at the first study visit...
October 12, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30307778/oral-medication-adherence-among-adolescents-and-young-adults-with-cancer-before-and-following-use-of-a-smartphone-based-medication-reminder-app
#3
Lauri A Linder, Yelena P Wu, Catherine Fiona Macpherson, Brynn Fowler, Andrew Wilson, Yeonjung Jo, Se-Hee Jung, Bridget Parsons, Rebecca Johnson
PURPOSE: This study evaluated oral medication adherence among adolescents and young adults (AYAs) with cancer during a trial of a smartphone-based medication reminder application (app). METHODS: Twenty-three AYAs receiving at least one prescribed, scheduled oral medication related to their outpatient cancer treatment participated in this 12-week single-group interrupted time series longitudinal design study. Baseline oral medication adherence was monitored using electronic monitoring caps for 4 weeks...
October 10, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30307359/documentation-of-late-effects-risks-and-screening-recommendations-for-adolescent-and-young-adult-central-nervous-system-soft-tissue-or-bone-tumor-survivors-treated-with-radiotherapy-in-british-columbia-canada
#4
A Fuchsia Howard, Jordan Tran, Analuisa Aparicio, Andrea Lo, Avril Ullett, Michael McKenzie, Amirrtha Srikanthan, Karen Goddard
PURPOSE: To assess the documentation of late-effects (LE) risks and screening recommendations in medical records of adolescent and young adult central nervous system (CNS), soft tissue, and bone tumor survivors. METHODS: The medical records of all patients diagnosed with a CNS neoplasm, an arteriovenous malformation, a soft tissue, and bone tumor, at ages 15-39 years, treated between 1985 and 2010 with radiation therapy in the province of British Columbia, Canada, surviving >5 years, alive, and discharged to the community were assessed...
October 9, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30300045/how-and-why-school-is-important-to-teenagers-with-cancer-outcomes-from-a-photo-elicitation-study
#5
Simon Pini, Peter Gardner, Siobhan Hugh-Jones
BACKGROUND: Being diagnosed with cancer during the teenage years can be significant given that young people are at a key developmental, educational, and future-planning stage. Little is known about young people's attitude toward and engagement with school postdiagnosis, nor how this changes over time. We adopted a novel qualitative approach to examine accounts over time of young people recently diagnosed with cancer. METHODS: Twelve teenagers (13-16 years), recently diagnosed with cancer, participated in photo-elicitation interviews at three time points (∼2, 6, and 9 months postdiagnosis), generating 30 interviews in total...
October 6, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30281375/early-detection-of-ovarian-dysfunction-by-anti-mullerian-hormone-in-adolescent-and-young-adult-aged-survivors-of-childhood-cancer
#6
Sobenna A George, Rebecca Williamson Lewis, David A Schirmer, Karen E Effinger, Jessica B Spencer, Ann C Mertens, Lillian R Meacham
PURPOSE: Current guidelines recommend screening at-risk childhood cancer survivors for ovarian dysfunction using follicle-stimulating hormone (FSH). However, FSH identifies diminished ovarian reserve (DOR), a component of ovarian dysfunction, in the later stages when fertility preservation is less likely to succeed. This analysis evaluates the utility of anti-Mullerian hormone (AMH) for the assessment of DOR in adolescent and young adult (AYA)-aged survivors of childhood cancer. METHODS: A retrospective chart review of 13- to 21-year-old female survivors who received gonadotoxic therapy and were ≥2 years off therapy was performed...
October 3, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30260730/interest-in-learning-about-fertility-status-among-male-adolescent-and-young-adult-survivors-of-childhood-cancer
#7
Amanda C Ferrante, Cynthia A Gerhardt, Nicholas D Yeager, Joseph R Rausch, Vicky Lehmann, Sarah O'Brien, Gwendolyn P Quinn, Leena Nahata
PURPOSE: As many as two-thirds of male childhood cancer survivors are at risk for fertility impairment as a consequence of treatment. Despite this, survivorship guidelines lack concrete recommendations as to when fertility status conversations should happen between patients and providers and what should be discussed. Thus, conversations may be inconsistent, or do not occur at all in survivorship. To inform recommendations for fertility-related conversations in survivorship, this pilot study aimed to better understand background (e...
September 27, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30256151/patient-and-physician-perspective-on-sperm-banking-to-overcome-post-treatment-infertility-in-young-cancer-patients-in-pakistan
#8
Nida Latif, Natasha Ali
BACKGROUND: Cancer survivor rates have increased over the past few decades leading to a growing interest in research related to quality of life (QoL). We attempted to explore the unique barriers that might prevent adult male cancer patients from accessing sperm cryopreservation in Pakistan. METHODS: Semi-structured interviews of male cancer patients aged 18-45 years were audio-recorded in Urdu and translated to English and were transcribed ad verbatim. The topics included information regarding risk of infertility following chemotherapy, future reproductive choices, and barriers to sperm cryopreservation...
September 25, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30251903/social-well-being-in-adolescent-and-young-adult-cancer-survivors
#9
Sinead M Sinnott, Crystal L Park
PURPOSE: Adolescents and young adults (AYAs) diagnosed with cancer between ages 15-39 years are a unique and vulnerable population, encountering many typical developmental challenges while also dealing with the demands of illness and its aftermath. Overwhelming evidence demonstrates the importance of social well-being in survivorship quality of life. For AYAs, social connections may be of heightened importance as they assert independence from their parents and create their own personal lives...
September 22, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30239252/high-dose-vincristine-sulfate-liposome-injection-for-advanced-relapsed-or-refractory-philadelphia-chromosome-negative-acute-lymphoblastic-leukemia-in-an-adolescent-and-young-adult-subgroup-of-a-phase-2-clinical-trial
#10
Gary J Schiller, Lloyd E Damon, Steven E Coutre, Pamela Hsu, Gajanan Bhat, Dan Douer
PURPOSE: A study of vincristine sulfate (VCR) liposome injection (VSLI) was conducted in patients with advanced, relapsed, or refractory, Philadelphia chromosome-negative acute lymphoblastic/lymphocytic leukemia (ALL). A retrospective subgroup analysis of the results was performed to evaluate the safety and efficacy of VSLI in the adolescent and young adult (AYA) patients. METHODS: Of the 65 patients treated in the pivotal Phase 2 Study HBS407 (NCT00495079), 44 patients were aged ≤39 years (median 27 [range 19-39] years) and were included in this analysis...
September 21, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30222486/population-based-survey-methods-for-reaching-adolescent-and-young-adult-survivors-of-pediatric-cancer-and-their-parents
#11
Ann S Hamilton, Xueyan Zhuang, Denise Modjeski, Rhona Slaughter, Anamara Ritt-Olson, Joel Milam
PURPOSE: Contacting childhood cancer survivors (CCS) to assess reasons for declining receipt of follow-up care after treatment is difficult and participation in surveys may be low, resulting in biased results. We sought to demonstrate effective recruitment and population-based sampling methods to improve response and minimize bias. METHODS: Four hundred and seventy CCS diagnosed between 2000 and 2007 at two hospitals in Los Angeles County were selected from the California Cancer Registry and were 15-25 years of age at the time of interview...
September 15, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30192163/radiation-therapy-for-treatment-of-adolescent-and-young-adult-hodgkin-lymphoma-and-risk-for-cardiovascular-disease-and-cancer
#12
Kathrine Rugbjerg, Jørgen H Olsen
PURPOSE: To estimate the risk for hospitalizations among survivors of Hodgkin lymphoma diagnosed in adolescence or young adulthood according to exposure to treatment with radiation therapy. METHODS: Through the files of the Danish Cancer Registry, we identified 1684 five-year survivors of Hodgkin lymphoma, diagnosed at age 15-39 years during the period 1943-2004, and for whom information on radiation therapy was available in the Cancer Registry. Population-based comparisons were identified through the Danish Civil Registration System and matched to the survivors on year of birth and sex...
September 15, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30183444/adolescent-males-understanding-of-infertility-as-a-long-term-effect-of-cancer-therapy
#13
Sophie I G Roher, Abha A Gupta, Barbara E Gibson, Armando J Lorenzo, Jennifer L Gibson
Cancer therapy can result in infertility in childhood cancer survivors; however, little is known about how young adolescent males make sense of infertility and potential future parenthood. What's more, research shows that many healthcare professionals in Canada do not discuss fertility preservation (FP) with this vulnerable population. This study examines how male adolescent childhood cancer survivors understand infertility as a long-term effect of cancer treatments. We used a narrative analysis to examine 16 interviews with 14-18-year-old males...
September 5, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30156442/dual-liminality-a-framework-for-conceptualizing-the-experience-of-adolescents-and-young-adults-with-cancer
#14
Steve Marshall, Anne Grinyer, Mark Limmer
PURPOSE: The concept of liminality has been applied to both the experience of adolescence and to the experience of a cancer diagnosis. The aim of this study was to explore how the concept of liminality can be applied to a cohort of patients experiencing both adolescence and cancer concurrently. METHODS: Thematic analysis was applied to data from interviews with 17 participants who had been treated for cancer between the ages of 15 and 24 in an adult hospital. As the analysis developed, it became apparent that liminality was a useful conceptual framework to be applied to the data...
August 29, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30156441/adolescent-and-young-adult-brain-tumor-survivors-report-increased-anxiety-even-years-after-successful-treatment-for-relapse
#15
Candice Chow, Cori Liptak, Christine Chordas, Peter Manley, Christopher Recklitis
Among survivors of pediatric cancers, brain tumor survivors are comparatively at high risk for experiencing relapsed disease. However, little is known about how disease relapse affects long-term psychological functioning in this cohort. This study of 162 pediatric brain tumor survivors, now adolescents and young adults (ages 12-36), demonstrates that survivors who have experienced relapsed disease are at increased risk for symptoms of anxiety, even years after successful treatment for relapse. Results underscore the need for adolescent and young adult survivors, particularly those with a history of relapsed disease, to receive ongoing psychosocial assessment and intervention that is integrated with their oncology follow-up care...
August 29, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30156439/addressing-fertility-in-adolescent-and-young-adult-oncology-patients-a-descriptive-study
#16
Breanne M Roche, Susan R Mazanec, Valerie Boebel Toly, Irina Pateva
PURPOSE: Adolescents and young adults (AYA) undergoing cancer therapy may be at risk for infertility as a consequence of their treatment and should be informed of their risk of infertility and referred to infertility specialists at the time of diagnosis. The overall aim of the study was to describe fertility consult practices in AYA patients at a single institution. METHODS: We conducted a retrospective chart review over a 2-year time period collecting data on newly diagnosed or relapsed AYA oncology patients aged 10-30 years...
August 29, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30153089/oncofertility-decision-making-findings-from-israeli-adolescents-and-parents
#17
Dorit Barlevy, Tenzin Wangmo, Shifra Ash, Bernice S Elger, Vardit Ravitsky
PURPOSE: To date, few studies qualitatively investigate adolescent oncofertility decision making. This qualitative study seeks to understand the experiences of adolescents and parents in making oncofertility decisions within the pronatalist context of Israeli society. METHODS: Semi-structured interviews were conducted in Israel with adolescents between the ages of 12 and 19 years who were in remission for at least 2 months and had been offered fertility preservation (FP) of sperm, ova, or ovary cryopreservation, and their parents, separately...
August 28, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30141724/a-roadmap-to-survivorship-optimizing-survivorship-care-plans-for-adolescent-and-young-adult-cancer-survivors
#18
Lynda K Beaupin, Odochi C Uwazurike, Jennifer A Hydeman
PURPOSE: Young adult cancer patients have complex medical and psychosocial needs throughout treatment. Once treatment ends, few young adult cancer survivors (YACS) receive adequate survivorship care. Many YACS do not continue with oncology care after treatment ends. The purpose of this study was to discover the views YACS held about survivorship care and to design age-appropriate survivorship care plans (SCPs). METHODS: Twenty-seven YACS (n = 27) participated in a group discussion focusing on their post-treatment experience...
August 24, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30136876/dysautonomia-in-childhood-cancer-survivors-a-widely-underestimated-risk
#19
Claire Berger, Léonie Casagranda, Vincent Pichot, Béatrice Trombert-Paviot, Cécile Faure-Conter, Claire Freycon, Florentina Isfan, Isabelle Guichard, Isabelle Durieu, Arnauld Garcin, Fréderic Roche, Hugues Patural
PURPOSE: Survival rate of childhood cancers is now reaching 80% overall. However, early or late complications related to surgery, chemotherapy, and radiotherapy remain at a high rate and greatly increase the risk of late mortality. The objective of this study is to assess the autonomic nervous system (ANS) activity, measured through heart rate variability indices in childhood cancer survivors compared with healthy controls. METHODS: This prospective study included 51 long-term childhood cancer survivors diagnosed before 15 years of age between 1987 and 1992 and controlled for age and sex with healthy volunteers...
August 23, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/30113244/pain-outcomes-after-celiac-plexus-block-in-children-and-young-adults-with-cancer
#20
Doralina L Anghelescu, Andy Guo, Kyle J Morgan, Michael Frett, Hasmukh Prajapati, Robert Gold, Sara M Federico
PURPOSE: The use of celiac plexus block (CPB) for abdominal pain has been extensively reported in adults. However, pediatric literature is limited to three single case reports and a series of three cases. This study evaluated the effectiveness of CPB in children and young adults (aged 8-20 years) with abdominal malignancies. METHODS: Pain outcomes after CPB were evaluated in four children and young adults with cancer. Mean daily pain score (PS, 0-10) and morphine consumption (intravenous morphine equivalent daily [MED], mg/kg/day) before and after CPB were used to assess effectiveness...
August 16, 2018: Journal of Adolescent and Young Adult Oncology
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