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Journal of Adolescent and Young Adult Oncology

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https://www.readbyqxmd.com/read/28263668/monocytes-macrophages-and-osteoclasts-in-osteosarcoma
#1
Fergal C Kelleher, Hazel O'Sullivan
Macrophages appear to have a fundamental role in the pathogenesis of osteosarcoma. These highly diverse plastic cells are subdivided into classical or inflammatory macrophages known as M1 and alternative macrophages, which decrease inflammation and are reparative, called M2. Although primary and metastatic osteosarcomas are infiltrated with M2 macrophages, targeting the M1 macrophages with the immune adjuvant muramyl tripeptide phosphatidyl ethanolamine (MTP-PE) has been the greatest recent therapeutic advance in osteosarcoma...
March 6, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28221816/priorities-in-fertility-decisions-for-reproductive-aged-cancer-patients-fertility-attitudes-and-cancer-treatment-study
#2
Dina M Flink, Laxmi A Kondapalli, Yvonne Kellar-Guenther
PURPOSE: The Fertility Attitudes and Cancer Treatment Study (FACTS) aims at better understanding the reasons and priorities of young adult cancer patients making decisions for fertility preservation (FP). Identifying the factors that center around a patient's fertility decisions will support the development of educational tools for providers and improve clinical care to meet patients' reproductive needs. METHODS: An exploratory qualitative study was conducted of 27 newly diagnosed male and female cancer patients who had presented for an oncofertility consultation...
February 21, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28207291/small-numbers-big-challenges-adolescent-and-young-adult-cancer-incidence-and-survival-in-new-zealand
#3
Kirsten R Ballantine, Heidi Watson, Scott Macfarlane, Mark Winstanley, Robin P Corbett, Ruth Spearing, Vladimir Stevanovic, Ma Yi, Michael J Sullivan
PURPOSE: This study was undertaken to determine cancer survival and describe the unique spectrum of cancers diagnosed among New Zealand's adolescents and young adult (AYA) population. METHODS: Registrations for 1606 15-24 year olds diagnosed with a new primary malignant tumor between 2000 and 2009 were obtained from the New Zealand Cancer Registry and classified according to AYA diagnostic group and subgroup, age, sex, and prioritized ethnicity. Age-standardized incidence rates (IRs) per million person years and 5-year relative survival ratios were calculated...
February 16, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28207285/improvements-in-clinical-trials-information-will-improve-the-reproductive-health-and-fertility-of-cancer-patients
#4
Angela Dauti, Brigitte Gerstl, Serena Chong, Orin Chisholm, Antoinette Anazodo
There are a number of barriers that result in cancer patients not being referred for oncofertility care, which include knowledge about reproductive risks of antineoplastic agents. Without this information, clinicians do not always make recommendations for oncofertility care. The objective of this study was to describe the level of reproductive information and recommendations that clinicians have available in clinical trial protocols regarding oncofertility management and follow-up, and the information that patients may receive in clinical trials patient information sheets or consent forms...
February 16, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28186840/fertility-preservation-care-for-children-and-adolescents-with-cancer-an-inquiry-to-quantify-professionals-barriers
#5
Nikoletta Panagiotopoulou, Frederik W van Delft, Juliet P Hale, Jane A Stewart
PURPOSE: There is a growing interest in fertility preservation as emerging research is highlighting the prevalence of infertility among young cancer survivors and its negative impact on quality of life. Previous qualitative research has identified barriers of fertility preservation care among professionals. The aim of this study was to assess the prevalence of these barriers among pediatric and adolescent oncology healthcare professionals and evaluate factors that influence them. METHODS: Based on previously identified barriers and experts' input, a questionnaire was developed and sent to 88 professionals drawn from the multidisciplinary pediatric and adolescent oncology team of a large Principal Treatment Centre...
February 10, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28165844/the-health-behavior-information-needs-and-preferences-of-teenage-and-young-adult-cancer-survivors
#6
Gemma Pugh, Rachael E Hough, Helen L Gravestock, Sarah E Jackson, Abigail Fisher
PURPOSE: This study aimed to establish teenage and young adult cancer survivors (TYACS') specific interest in receiving information on physical activity, diet, smoking, and alcohol consumption and their preferences regarding the delivery, format, and timing of such health behaviour information. METHODS: TYACS aged 13-25 years were invited to complete a questionnaire assessing the advice they had received in the past and their preferences on when and how health behavior information should be delivered...
February 6, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28128672/cancer-related-worry-and-physical-well-being-in-the-context-of-perceived-stress-in-young-adults-with-testicular-cancer
#7
Katie Darabos, Michael A Hoyt
Uncertainty associated with cancer can foster future-focused worry and ultimately diminish physical well-being, especially among young adult survivors. Stress perceptions might exacerbate the association of worry and physical well-being. Young adults with testicular cancer (N = 171) completed measures of physical well-being, perceived stress, and future cancer-related worry. Perceived stress and future worry were both negatively associated with physical well-being. Perceived stress moderated the relationship; more perceived stress was related to lower physical well-being in those with high worry...
January 27, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28118063/anthropometry-in-long-term-survivors-of-acute-lymphoblastic-leukemia-in-childhood-and-adolescence
#8
Laura Collins, Lesley Beaumont, Amy Cranston, Stefanie Savoie, Trishana Nayiager, Ronald Barr
PURPOSE: Body mass index (BMI) is an inadequate measure of nutritional status in children and adolescents with cancer as it does not distinguish muscle from adipose tissue. However, arm anthropometry offers simple assessments of fat mass and lean body mass; especially valuable in low- and middle-income countries where the great majority of young people with cancer live and access to sophisticated expensive measures of body composition is markedly limited. METHODS: The nutritional status of 75 long-term survivors of acute lymphoblastic leukemia was assessed by arm anthropometry, in addition to BMI, in a cross-sectional cohort study...
January 24, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28112547/body-image-discomfort-of-adolescent-and-young-adult-hematologic-cancer-survivors
#9
Giulia Zucchetti, Simona Bellini, Marina Bertolotti, Francesca Bona, Eleonora Biasin, Nicoletta Bertorello, Elisa Tirtei, Franca Fagioli
This study focuses on body image discomfort (BID) of 50 adolescent and young adult (AYA) hematologic cancer survivors (age range 15-23; 52% males). The study results were obtained through data from a self-report questionnaire: the Body Uneasiness Test. Findings differed according to gender: a greater proportion of females were in the Risk category of impaired body image than males (χ(2) = 5.258, p < 0.05). No significant body image differences were found according to the type of diagnosis or to the length of survival...
January 23, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28112543/decision-on-fertility-preservation-in-cancer-patients-development-of-information-materials-for-healthcare-professionals
#10
Cristina Silva, Ana Teresa Almeida-Santos, Cláudia Melo, Ana Cristina Ribeiro Rama
Infertility is a potential side effect of cancer chemotherapy. As the number of adolescent and young adult (AYA)-aged survivors increases, future fertility becomes an important issue. However, many patients are not adequately informed and oncologists point the lack of information as a barrier to discussion. Our aim was to produce information materials tailored to oncologists' needs to promote and support discussion on infertility risk and fertility preservation (FP) with AYA-aged patients. After literature review, information materials were successfully developed and are currently being distributed to healthcare professionals in Portugal, with the collaboration of several national organizations...
January 23, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28103126/survivorship-care-planning-and-unmet-information-and-service-needs-among-adolescent-and-young-adult-cancer-survivors
#11
L Aubree Shay, Helen M Parsons, Sally W Vernon
PURPOSE: To examine whether survivorship care planning (receipt of written treatment summary or instructions for follow-up care) is associated with unmet needs among adolescent and young adult (AYA) cancer survivors (aged 15-39 at diagnosis). METHODS: We used data from the 2010 LIVESTRONG Survey for People Affected by Cancer. Outcome variables were survivor reports of unmet needs, including information on late effects of cancer treatment, fertility issues, cancer recurrence, and family cancer risk...
January 19, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28085535/fertility-sparing-surgery-should-be-the-standard-treatment-in-patients-with-malignant-ovarian-germ-cell-tumors
#12
Osman Turkmen, Alper Karalok, Derman Basaran, Gunsu Comert Kimyon, Tolga Tasci, Isin Ureyen, Gokhan Tulunay, Taner Turan
PURPOSE: To validate the oncological safety of fertility preservation in malignant ovarian germ cell tumors (MOGCTs) and to define the significance of maximal cytoreduction in early stage MOGCTs. MATERIALS AND METHODS: Sixty-nine patients with stage I and II MOGCTs who underwent surgical treatment were included in the study. Fertility-sparing surgery is defined as conservative surgery and hysterectomy and contralateral salpingo-oophorectomy were defined as definitive surgery...
January 13, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28075655/experiences-and-preferences-for-end-of-life-care-for-young-adults-with-cancer-and-their-informal-carers-a-narrative-synthesis
#13
Nothando Ngwenya, Charlotte Kenten, Louise Jones, Faith Gibson, Susie Pearce, Mary Flatley, Rachael Hough, L Caroline Stirling, Rachel M Taylor, Geoff Wong, Jeremy Whelan
To review the qualitative literature on experiences of and preferences for end-of-life care of people with cancer aged 16-40 years (young adults) and their informal carers. A systematic review using narrative synthesis of qualitative studies using the 2006 UK Economic and Social Research Council research methods program guidance. Seven electronic bibliographic databases, two clinical trials databases, and three relevant theses databases were searched from January 2004 to October 2015. Eighteen articles were included from twelve countries...
January 11, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28072554/personality-traits-and-health-related-quality-of-life-among-adolescent-and-young-adult-cancer-patients-the-role-of-psychological-distress
#14
Olga Husson, Bradley Zebrack, Rebecca Block, Leanne Embry, Christine Aguilar, Brandon Hayes-Lattin, Steve Cole
Personality may affect the way adolescents and young adults (AYAs) with cancer report health-related quality of life (HRQoL). Patients aged 15-39 years (n = 165) completed a survey at 12-16 months postdiagnosis. The survey included questions on HRQoL (SF-36), distress Brief Symptom Inventory-18, and personality (NEO-Five-Factor Inventory). Personality traits were not associated with physical HRQoL. The personality trait neuroticism was negatively associated with mental HRQoL (β = -0.37; p < 0...
January 10, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28061034/delayed-diagnosis-of-a-nasal-type-lymphoma-misdiagnosed-as-persistent-sinusitis
#15
Antonio Celentano, Massimo Mascolo, Nicola Cirillo, Gaetano De Rosa, Michele Davide Mignogna
Nasal Type T/natural killer (NK)-cell lymphomas are rare clinical entities, highly aggressive with a very poor prognosis. We present a case of a 37-year-old immunocompetent man presenting with deep palatal ulceration and a 3-month history of symptoms, which appear to have been misdiagnosed by physicians. The final diagnosis was achieved by a 15-day diagnostic algorithm, during which time the clinical status of the patient worsened severely. In this article, we also provide a succinct update on the clinical and histopathological findings of Peripheral T/NK-cell lymphomas and propose that symptoms that are consistent with these clinical entities should be considered from the early stages to inform a suitable diagnostic pathway Because of their highly aggressive behavior, we suggest that early therapy of T/NK-cell lymphomas may be started before completing the specific diagnostic investigations...
January 6, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28051344/trends-in-cancer-mortality-among-adolescents-and-young-adults-in-brazil
#16
Nathalie Vieira Balmant, Rejane de Souza Reis, Marceli de Oliveira Santos, Julio Pinto Oliveira, Beatriz de Camargo
PURPOSE: Adolescents and young adults (AYA) with cancer comprise an intermediate age group between pediatric and adult oncology, and have a spectrum of different types of cancers. Survival among this group has not improved as much as in younger children with cancer. The aim of this study was evaluate the trends in cancer mortality of AYA aged 15-29 years in Brazil. METHODS: Data were extracted from the Atlas of Cancer Mortality databases from 1979 to 2013. Age-specific mortality rates were calculated based on the deaths from each type of cancer and the period via a direct method using the proposed world population age groups...
January 4, 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/28080182/multi-professional-perspectives-on-adolescent-and-young-adult-oncology-across-europe-an-e-delphi-survey
#17
Simon A Pini, Faith Gibson, Lorna A Fern, Sue J Morgan, Robert S Phillips, Dan P Stark
The aims of this article are to describe the ongoing development of adolescent and young adult (AYA) cancer services within the European Union (EU), and to develop consensus on key areas within the field. This survey used an e-Delphi design. An initial survey was distributed via email to professionals working in Europe. A snowball sampling technique was used to promote distribution. Consensus was sought over three rounds from October 2012 to April 2015. Consensus was defined as >80% agreement ("agree" or "strongly agree")...
March 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27841952/prescriptions-of-antidepressants-to-survivors-of-cancer-in-childhood-adolescence-and-young-adulthood-a-population-based-study
#18
Inga Maria Johannsdottir, Øystein Karlstad, Jon H Loge, Sophie D Fosså, Cecilie Kiserud, Svetlana Skurtveit
PURPOSE: Survivors of cancer may experience higher rates of psychological problems requiring pharmacological interventions than age-matched controls from the general population. This study compares prescription rates of antidepressants in survivors of cancer, diagnosed in childhood, adolescence, or early adulthood, to the rate in age- and gender-matched controls from the Norwegian population. METHODS: Antidepressants prescribed to 5341 cancer survivors, diagnosed ≤25 years during 1965-2000, were studied in a population-based cohort by linking data from the following nationwide registries: the Population Registry of Norway, the Cancer Registry of Norway, and the Norwegian Prescription Database...
March 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27828715/validation-of-three-previously-developed-short-forms-of-the-beck-depression-inventory-for-youth-a-replication
#19
Jaime E Blackmon, Cori Liptak, Christopher J Recklitis
Three previously developed short forms of the Beck Depression Inventory-Youth (BDI-Y) were validated against the standard 20-item BDI-Y; 168 adolescent survivors completed the standard and short-form versions of the BDI-Y. The short forms were evaluated for internal consistency and compared with the standard BDI-Y using correlation coefficients and receiver operating characteristic curve analyses. The three short forms had good internal consistency (α > 0.85), high correlations with the total BDI-Y scale (r > 0...
March 2017: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27792462/what-a-pain-the-impact-of-physical-symptoms-and-health-management-on-pursuit-of-personal-goals-among-adolescents-with-cancer
#20
Lisa A Schwartz, Lauren D Brumley
PURPOSE: This study examined health-related hindrance (HRH) of personal goals among adolescents receiving treatment for cancer and healthy peers. METHODS: Adolescents and parents completed measures of demographics and psychosocial variables. Adolescents reported on their HRH, measured by ratings of the impact of pain, fatigue, other physical symptoms, and doing things to manage their health on self-identified personal goals. Disease-related information was abstracted from patient charts...
March 2017: Journal of Adolescent and Young Adult Oncology
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