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Journal of Asthma and Allergy

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https://www.readbyqxmd.com/read/28392708/lung-sound-analysis-helps-localize-airway-inflammation-in-patients-with-bronchial-asthma
#1
Terufumi Shimoda, Yasushi Obase, Yukio Nagasaka, Hiroshi Nakano, Akiko Ishimatsu, Reiko Kishikawa, Tomoaki Iwanaga
PURPOSE: Airway inflammation can be detected by lung sound analysis (LSA) at a single point in the posterior lower lung field. We performed LSA at 7 points to examine whether the technique could identify the location of airway inflammation in patients with asthma. PATIENTS AND METHODS: Breath sounds were recorded at 7 points on the body surface of 22 asthmatic subjects. Inspiration sound pressure level (ISPL), expiration sound pressure level (ESPL), and the expiration-to-inspiration sound pressure ratio (E/I) were calculated in 6 frequency bands...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28392707/factors-predicting-persistence-of-early-wheezing-through-childhood-and-adolescence-a-systematic-review-of-the-literature
#2
Carlos E Rodríguez-Martínez, Monica P Sossa-Briceño, Jose A Castro-Rodriguez
BACKGROUND: For the early identification of persistent asthma symptoms among young children with recurrent wheezing, it would be helpful to identify all available studies that have identified at least one factor for predicting the persistence of early wheezing. The objective of the present study was to perform a systematic review of all studies that have identified factors that predict the persistence of symptoms among young patients with recurring wheezing. METHODS: A systematic review of relevant studies was conducted through searching in MEDLINE, EMBASE, CINHAL, and SCOPUS databases up to June 2016...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28356764/study-of-nasal-exhaled-nitric-oxide-levels-in-diagnosis-of-allergic-rhinitis-in-subjects-with-and-without-asthma
#3
Sy Duong-Quy, Thuc Vu-Minh, Thong Hua-Huy, Tram Tang-Thi-Thao, Khiet Le-Quang, Dinh Tran-Thanh, Nhu Doan-Thi-Quynh, Nhat-Nam Le-Dong, Timothy J Craig, Anh-Tuan Dinh-Xuan
BACKGROUND: The measure of fractional exhaled nitric oxide (FENO) in the airways is a useful tool to guide the diagnosis and titration of inhaled corticosteroids in patients with asthma. However, its role in diagnosis of allergic rhinitis (AR), especially in subjects with asthma, is not well established. OBJECTIVE: To study the cutoff of nasal FENO in the diagnosis of subjects with AR and AR-asthma compared to age-matched subjects without AR or asthma and its correlations with the clinical and functional characteristics...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28356763/the-us-food-and-drug-administration-s-drug-safety-recommendations-and-long-acting-beta2-agonist-dispensing-pattern-changes-in-adult-asthma-patients-2003-2012
#4
Esther H Zhou, Sally Seymour, Margie R Goulding, Elizabeth M Kang, Jacqueline M Major, Solomon Iyasu
BACKGROUND: Emerging safety issues associated with long-acting beta2-agonist (LABA) have led to multiple regulatory activities by the US Food and Drug Administration (FDA) since 2003, including Drug Safety Communications (DSCs) in 2010. These DSCs had three specific recommendations for the safe use of LABA products in adult asthma treatment. METHODS: We examined the initiation of LABA-containing products for adult asthma treatment using an intermittent time series approach in a claims database from 2003 to 2012...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28352197/development-of-an-allergy-management-support-system-in-primary-care
#5
Bertine Mj Flokstra-de Blok, Thys van der Molen, Wianda A Christoffers, Janwillem Wh Kocks, Richard L Oei, Joanne Ng Oude Elberink, Emmy M Roerdink, Marie Louise Schuttelaar, Jantina L van der Velde, Thecla M Brakel, Anthony Ej Dubois
BACKGROUND: Management of allergic patients in the population is becoming more difficult because of increases in both complexity and prevalence. Although general practitioners (GPs) are expected to play an important role in the care of allergic patients, they often feel ill-equipped for this task. Therefore, the aim of this study was to develop an allergy management support system (AMSS) for primary care. METHODS: Through literature review, interviewing and testing in secondary and primary care patients, an allergy history questionnaire was constructed by allergists, dermatologists, GPs and researchers based on primary care and specialists' allergy guidelines and their clinical knowledge...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28331347/environmental-triggers-and-avoidance-in-the-management-of-asthma
#6
REVIEW
Clarisse Gautier, Denis Charpin
Identifying asthma triggers forms the basis of environmental secondary prevention. These triggers may be allergenic or nonallergenic. Allergenic triggers include indoor allergens, such as house dust mites (HDMs), molds, pets, cockroaches, and rodents, and outdoor allergens, such as pollens and molds. Clinical observations provide support for the role of HDM exposure as a trigger, although avoidance studies provide conflicting results. Molds and their metabolic products are now considered to be triggers of asthma attacks...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28331346/control-of-moderate-to-severe-asthma-with-randomized-ciclesonide-doses-of-160-320-and-640-%C3%AE-g-day
#7
Søren E Pedersen, Niyati Prasad, Udo-Michael Goehring, Henrik Andersson, Dirkje S Postma
BACKGROUND: The inhaled corticoteroid (ICS) ciclesonide (Cic), controls asthma symptoms in the majority of patients at the recommended dose of 160 µg/day. However, the relationship between the level of asthma control and increasing doses of Cic is unknown. This study investigated whether long-term treatment with higher doses of Cic would further improve asthma symptoms in patients with uncontrolled asthma despite ICS use. PATIENTS AND METHODS: In a double-blind, randomized, parallel-group study, 367 patients were allocated to one of three treatment arms (Cic 160, 320 and 640 µg/day)...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28280372/pediatric-anaphylaxis-and-hyper-ige-syndrome
#8
Amrita Dosanjh
Patients with autosomal-dominant (AD) hyper immunoglobulin E (IgE) syndrome (HIES) or Job syndrome develop frequent dermatologic and pulmonary infections. As patients have an extreme elevation of IgE levels, this database analysis study sought to study the association between AD HIES, Job syndrome, and anaphylaxis. HIES is a heterogeneous group of immune disorders characterized by extremely elevated levels of serum IgE. Although the molecular defects and clinical phenotypes found in association with Job syndrome are well characterized, the association with severe allergic reactions and anaphylaxis is a subject of ongoing investigation...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28280371/evaluation-of-a-sublingual-immunotherapy-solution-in-olive-induced-respiratory-allergy-in-jordan-a-retrospective-observational-study
#9
Khaled Al-Asad, Sayed Al-Nazer, Anan Al-Faqih, Mohammad Jamil Hashem
BACKGROUND: Olive pollen is an important cause of respiratory allergy in the Middle East. In this study, the clinical characteristics of adults and children with confirmed allergic rhinitis (AR; with or without asthma) in Jordan were described, and the use of sublingual immunotherapy (SLIT) in a real-life clinical setting was assessed. METHODS: This retrospective observational study evaluated the clinical features of olive-induced allergy and the use of an SLIT solution of standardized extracts toward Ole e 1 given in a pre- and coseasonal scheme with a daily dose of 300 index of reactivity for two consecutive seasons...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28260934/peak-inspiratory-flow-rate-measurement-by-using-in-check-dial-for-the-different-inhaler-devices-in-elderly-with-obstructive-airway-diseases
#10
Theerasuk Kawamatawong, Supattra Khiawwan, Prapaporn Pornsuriyasak
BACKGROUND: Inhaler device technique is a common cause of treatment failure in patients with asthma and chronic obstructive pulmonary disease. Dry powder inhaler (DPI) requires optimal peak inspiratory flow rate (PIFR) for drug delivery. Low PIFR generation is common in the elderly. Patient lung function and intrinsic inhaler resistance are factors for determining generated PIFR and drug delivery from DPI. OBJECTIVES: We aimed to identify the PIFR of the older (aged >60 years) and the younger (aged ≤60 years) patients with obstructive airway diseases for the different inhaler devices (Turbuhaler(®) and Accuhaler)...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28176912/para-phenylenediamine-allergy-current-perspectives-on-diagnosis-and-management
#11
REVIEW
Krishna Sumanth Mukkanna, Natalie M Stone, John R Ingram
Para-phenylenediamine (PPD) is the commonest and most well-known component of hair dyes. Oxidative hair dyes and dark henna temporary tattoos contain PPD. Individuals may be sensitized to PPD by temporary henna tattooing in addition to dyeing their hair. PPD allergy can cause severe reactions and may result in complications. In recent years, frequency of positive patch test reactions to PPD has been increasing. Cross-sensitization to other contact allergens may occur, in particular to other hair dye components...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28115856/anaphylaxis-across-two-canadian-pediatric-centers-evaluating-management-disparities
#12
Alison Ym Lee, Paul Enarson, Ann E Clarke, Sébastien La Vieille, Harley Eisman, Edmond S Chan, Christopher Mill, Lawrence Joseph, Moshe Ben-Shoshan
BACKGROUND: There are no data on the percentage of visits due to anaphylaxis in the emergency department (ED), triggers, and management of anaphylaxis across different provinces in Canada. OBJECTIVE: To compare the percentage of anaphylaxis cases among all ED visits, as well as the triggers and management of anaphylaxis between two Canadian pediatric EDs (PEDs). METHODS: As part of the Cross-Canada Anaphylaxis Registry (C-CARE), children presenting to the British Columbia Children's Hospital (BCCH) and Montreal Children's Hospital (MCH) EDs with anaphylaxis were recruited...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28008277/technical-and-clinical-validation-of-an-environmental-exposure-unit-for-ragweed
#13
Paul J Gomes, Keith J Lane, Endri Angjeli, Linda Stein, Mark B Abelson
BACKGROUND: Allergic rhinitis is a common condition, with ragweed pollen one of the more prevalent aeroallergens. Environmental exposure units such as the Allergen BioCube(®) are valuable models for clinical allergy studies. A study was conducted to validate the Allergen BioCube for uniform ragweed pollen concentrations and clinically relevant sign and symptom responses to ragweed exposure. METHODS: Ragweed pollen concentrations were measured on 3 consecutive days in the Allergen BioCube and verified by Rotorod collection and continuous laser particle count measurements...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27942227/aquagenic-urticaria-diagnostic-and-management-challenges
#14
REVIEW
Robert Rothbaum, Jean S McGee
Aquagenic urticaria (AU) is a rare inducible form of physical urticaria, which occurs in response to cutaneous exposure to water, including sweat and tears. Patients present with characteristic 1-3 mm folliculocentric wheals with surrounding 1-3 cm erythematous flares within 20-30 minutes following skin contact with water. In rare cases, there are concomitant systemic symptoms, such as wheezing or shortness of breath. The pathogenesis of AU is poorly understood at this time, and it appears to be mediated in both a histamine-dependent and independent manner...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27920561/erratum-diagnosis-of-exercise-induced-anaphylaxis-current-insights-corrigendum
#15
(no author information available yet)
[This corrects the article on p. 191 in vol. 7.].
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27877057/chronic-sphenoid-rhinosinusitis-management-challenge
#16
REVIEW
Natamon Charakorn, Kornkiat Snidvongs
Chronic sphenoid rhinosinusitis is a spectrum of inflammatory diseases in isolated sphenoid sinus which may persist over a period of 12 weeks. It is a different entity from other types of rhinosinusitis because clinical presentations include headache, visual loss or diplopia, and patients may or may not have nasal obstruction or nasal discharge. Nasal endoscopic examination is useful, and computed tomography is mandatory. The disease requires comprehensive knowledge and appropriate imaging technique for diagnosis...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27822074/diagnosis-of-exercise-induced-anaphylaxis-current-insights
#17
REVIEW
Valerio Pravettoni, Cristoforo Incorvaia
Exercise-induced anaphylaxis (EIAn) is defined as the occurrence of anaphylactic symptoms (skin, respiratory, gastrointestinal, and cardiovascular symptoms) after physical activity. In about a third of cases, cofactors, such as food intake, temperature (warm or cold), and drugs (especially nonsteroidal anti-inflammatory drugs) can be identified. When the associated cofactor is food ingestion, the correct diagnosis is food-dependent EIAn (FDEIAn). The literature describes numerous reports of FDEIAn after intake of very different foods, from vegetables and nuts to meats and seafood...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27785078/anti-inflammatory-dosing-of-theophylline-in-the-treatment-of-status-asthmaticus-in-children
#18
Nemr S Eid, Adrian O'Hagan, Scott Bickel, Ronald Morton, Sarah Jacobson, John A Myers
BACKGROUND: Low-dose theophylline has been recognized for its ability to restore histone deacetylase-2 activity which leads to improved steroid responsiveness and thus improved clinical outcome. We retrospectively evaluated the effect of low-dose theophylline therapy in pediatric patients hospitalized for an acute asthma exacerbation as a proof of concept study. METHODS: We compared patients who received low-dose theophylline (5-7 mg/kg/day) in addition to current standard of care to patients who were treated with current standard of care alone...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27703382/chronic-hypersensitivity-pneumonitis
#19
REVIEW
Carlos Ac Pereira, Andréa Gimenez, Lilian Kuranishi, Karin Storrer
Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27695350/study-of-the-correlations-between-fractional-exhaled-nitric-oxide-in-exhaled-breath-and-atopic-status-blood-eosinophils-fcer2-mutation-and-asthma-control-in-vietnamese-children
#20
Hanh Nguyen-Thi-Bich, Huong Duong-Thi-Ly, Vu Thi Thom, Nhung Pham-Thi-Hong, Long Doan Dinh, Huong Le-Thi-Minh, Timothy John Craig, Sy Duong-Quy
INTRODUCTION: Fractional exhaled nitric oxide (FENO) is a biomarker of airway inflammation in asthma. The measurement of FENO is utilized to assist in the diagnosis and treatment of children with asthma, especially for those treated with inhaled corticosteroids. OBJECTIVES: The aims of this study were to evaluate the correlations between FENO and atopic status, blood eosinophil levels, FCER2 mutation, and asthma control in Vietnamese children. SUBJECTS AND METHODS: This was a prospective and descriptive study approved by the local Ethical Board...
2016: Journal of Asthma and Allergy
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