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Journal of Asthma and Allergy

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https://www.readbyqxmd.com/read/27877057/chronic-sphenoid-rhinosinusitis-management-challenge
#1
REVIEW
Natamon Charakorn, Kornkiat Snidvongs
Chronic sphenoid rhinosinusitis is a spectrum of inflammatory diseases in isolated sphenoid sinus which may persist over a period of 12 weeks. It is a different entity from other types of rhinosinusitis because clinical presentations include headache, visual loss or diplopia, and patients may or may not have nasal obstruction or nasal discharge. Nasal endoscopic examination is useful, and computed tomography is mandatory. The disease requires comprehensive knowledge and appropriate imaging technique for diagnosis...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27822074/diagnosis-of-exercise-induced-anaphylaxis-current-insights
#2
REVIEW
Valerio Pravettoni, Cristoforo Incorvaia
Exercise-induced anaphylaxis (EIAn) is defined as the occurrence of anaphylactic symptoms (skin, respiratory, gastrointestinal, and cardiovascular symptoms) after physical activity. In about a third of cases, cofactors, such as food intake, temperature (warm or cold), and drugs (especially nonsteroidal anti-inflammatory drugs) can be identified. When the associated cofactor is food ingestion, the correct diagnosis is food-dependent EIAn (FDEIAn). The literature describes numerous reports of FDEIAn after intake of very different foods, from vegetables and nuts to meats and seafood...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27785078/anti-inflammatory-dosing-of-theophylline-in-the-treatment-of-status-asthmaticus-in-children
#3
Nemr S Eid, Adrian O'Hagan, Scott Bickel, Ronald Morton, Sarah Jacobson, John A Myers
BACKGROUND: Low-dose theophylline has been recognized for its ability to restore histone deacetylase-2 activity which leads to improved steroid responsiveness and thus improved clinical outcome. We retrospectively evaluated the effect of low-dose theophylline therapy in pediatric patients hospitalized for an acute asthma exacerbation as a proof of concept study. METHODS: We compared patients who received low-dose theophylline (5-7 mg/kg/day) in addition to current standard of care to patients who were treated with current standard of care alone...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27703382/chronic-hypersensitivity-pneumonitis
#4
Carlos Ac Pereira, Andréa Gimenez, Lilian Kuranishi, Karin Storrer
Hypersensitivity pneumonitis (HSP) is a common interstitial lung disease resulting from inhalation of a large variety of antigens by susceptible individuals. The disease is best classified as acute and chronic. Chronic HSP can be fibrosing or not. Fibrotic HSP has a large differential diagnosis and has a worse prognosis. The most common etiologies for HSP are reviewed. Diagnostic criteria are proposed for both chronic forms based on exposure, lung auscultation, lung function tests, HRCT findings, bronchoalveolar lavage, and biopsies...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27695350/study-of-the-correlations-between-fractional-exhaled-nitric-oxide-in-exhaled-breath-and-atopic-status-blood-eosinophils-fcer2-mutation-and-asthma-control-in-vietnamese-children
#5
Hanh Nguyen-Thi-Bich, Huong Duong-Thi-Ly, Vu Thi Thom, Nhung Pham-Thi-Hong, Long Doan Dinh, Huong Le-Thi-Minh, Timothy John Craig, Sy Duong-Quy
INTRODUCTION: Fractional exhaled nitric oxide (FENO) is a biomarker of airway inflammation in asthma. The measurement of FENO is utilized to assist in the diagnosis and treatment of children with asthma, especially for those treated with inhaled corticosteroids. OBJECTIVES: The aims of this study were to evaluate the correlations between FENO and atopic status, blood eosinophil levels, FCER2 mutation, and asthma control in Vietnamese children. SUBJECTS AND METHODS: This was a prospective and descriptive study approved by the local Ethical Board...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27621657/reslizumab-in-the-management-of-poorly-controlled-asthma-the-data-so-far
#6
REVIEW
Diego Jose Maselli, Maria Ines Velez, Linda Rogers
Interleukin-5, an important cytokine in the pathophysiology of asthma, participates in terminal maturation and increases chemotaxis, endothelial adhesion, and activation of eosinophils. Blockade of interleukin-5 activity with monoclonal antibodies have been successful in decreasing eosinophil counts. Reslizumab, a monoclonal antibody that targets interleukin-5, has been studied for the treatment of severe asthma. Several studies have shown that reslizumab can effectively treat severe asthma with an eosinophilic phenotype...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27616891/historical-cohort-study-examining-comparative-effectiveness-of-albuterol-inhalers-with-and-without-integrated-dose-counter-for-patients-with-asthma-or-chronic-obstructive-pulmonary-disease
#7
David B Price, Anna Rigazio, Mary Buatti Small, Thomas J Ferro
BACKGROUND: Using a metered-dose inhaler (MDI) beyond the labeled number of actuations may result in inadequate dosing of medication, which can lead to poor clinical outcomes. This study compared respiratory-related emergency department (ED) visit rates in patients with asthma, chronic obstructive pulmonary disease, or both when they used albuterol MDIs with versus without dose counters. METHODS: This retrospective study used US claims data to identify patients (ages 4-64 years) with asthma, chronic obstructive pulmonary disease, or both, using albuterol MDIs with or without an integrated dose counter...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27468241/a-review-of-the-clinical-efficacy-and-safety-of-mp-azeflu-a-novel-intranasal-formulation-of-azelastine-hydrochloride-and-fluticasone-propionate-in-clinical-studies-conducted-during-different-allergy-seasons-in-the-us
#8
REVIEW
Bruce M Prenner
A novel intranasal formulation of azelastine HCl (AZE, an antihistamine) and fluticasone propionate (FP, a corticosteroid) in a single spray (MP-AzeFlu [Dymista®]) was studied in four randomized, double-blind, placebo-controlled trials of patients with seasonal allergic rhinitis conducted in the US. Study sites were distributed so that all major US geographic regions and the prevalent pollens within these regions were represented. Spring and summer studies included patients aged 12 years and older with allergy to grass and tree pollens...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27445499/smoking-cessation-strategies-for-patients-with-asthma-improving-patient-outcomes
#9
REVIEW
Jennifer L Perret, Billie Bonevski, Christine F McDonald, Michael J Abramson
Smoking is common in adults with asthma, yet a paucity of literature exists on smoking cessation strategies specifically targeting this subgroup. Adverse respiratory effects from personal smoking include worse asthma control and a predisposition to lower lung function and chronic obstructive pulmonary disease. Some data suggest that individuals with asthma are more likely than their non-asthmatic peers to smoke regularly at an earlier age. While quit attempts can be more frequent in smokers with asthma, they are also of shorter duration than in non-asthmatics...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27418842/adverse-reactions-and-tolerability-of-high-dose-sublingual-allergen-immunotherapy
#10
Angel Moral, Victoria Moreno, Francisco Girón, David El-Qutob, José D Moure, Manuel Alcántara, Antonia Padial, Alberto G Oehling, Carmen Millán, Fernando de la Torre
BACKGROUND: Sublingual allergen immunotherapy is an effective treatment against allergic respiratory disease. Many studies have shown the safety of this type of therapy, although the factors that might affect the tolerability of high-dose sublingual immunotherapy have not been well established. The aim of this study was to determine the factors that affect the tolerability of sublingual allergen immunotherapy. PATIENTS AND METHODS: A total of 183 subjects aged ≥5 years, diagnosed with allergic rhinitis with/without mild to moderate asthma due to sensitization to grass, olive pollen, or mites, were included in this open, retrospective, multicentric, noninterventional study...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27382317/training-and-administration-of-epinephrine-auto-injectors-for-anaphylaxis-treatment-in-us-schools-results-from-the-epipen4schools-%C3%A2-pilot-survey
#11
Susan L Hogue, Diana Goss, Kelly Hollis, Suyapa Silvia, Martha V White
BACKGROUND: Anaphylaxis is a serious, potentially life-threatening condition. Adequate preparation for anaphylaxis management is imperative for school personnel. This descriptive pilot study assessed preparedness of US schools to manage anaphylactic reactions. METHODS: An exploratory, cross-sectional, web-based, pilot survey assessed the occurrence and characteristics of anaphylactic events, as well as training provided to school personnel for the recognition and treatment of anaphylaxis...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27350756/update-on-the-role-of-alternatively-activated-macrophages-in-asthma
#12
REVIEW
Zhilong Jiang, Lei Zhu
Lung macrophages link innate and adaptive immune responses during allergic airway inflammatory responses. Alveolar macrophages (AMs) and interstitial macrophages are two different phenotypes that differentially exert immunological function under physiological and pathological conditions. Exposure to pathogen induces polarization of AM cells into classically activated macrophages (M1 cells) and alternatively activated macrophages (M2 cells). M1 cells dominantly express proinflammatory cytokines such as TNF-α and IL-1 β and induce lung inflammation and tissue damage...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27257389/united-airway-disease-current-perspectives
#13
REVIEW
Pedro Giavina-Bianchi, Marcelo Vivolo Aun, Priscila Takejima, Jorge Kalil, Rosana Câmara Agondi
Upper and lower airways are considered a unified morphological and functional unit, and the connection existing between them has been observed for many years, both in health and in disease. There is strong epidemiologic, pathophysiologic, and clinical evidence supporting an integrated view of rhinitis and asthma: united airway disease in the present review. The term "united airway disease" is opportune, because rhinitis and asthma are chronic inflammatory diseases of the upper and lower airways, which can be induced by allergic or nonallergic reproducible mechanisms, and present several phenotypes...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27143940/sleep-disordered-breathing-in-children-with-asthma-a-systematic-review-on-the-impact-of-treatment
#14
REVIEW
Trinidad Sánchez, José A Castro-Rodríguez, Pablo E Brockmann
BACKGROUND: The objective was to perform a systematic review in order to describe the relationship between asthma and sleep-disordered breathing (SDB) in children, especially regarding the impact of treatment and management. METHODS: We performed an electronic search in MEDLINE, EMBASE, and LILACS database. Study inclusion criteria were the following: 1) studies that examined the relationship between asthma/wheezing and SDB/obstructive sleep apnea (OSA); and 2) studies conducted in children <18 years of age...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27110133/benralizumab-a-unique-il-5-inhibitor-for-severe-asthma
#15
REVIEW
Laren D Tan, Jennifer M Bratt, Dorottya Godor, Samuel Louie, Nicholas J Kenyon
The presence of eosinophilic inflammation is a characteristic feature of chronic and acute inflammation in asthma. An estimated 5%-10% of the 300 million people worldwide who suffer from asthma have a severe form. Patients with eosinophilic airway inflammation represent approximately 40%-60% of this severe asthmatic population. This form of asthma is often uncontrolled, marked by refractoriness to standard therapy, and shows persistent airway eosinophilia despite glucocorticoid therapy. This paper reviews personalized novel therapies, more specifically benralizumab, a humanized anti-IL-5Rα antibody, while also being the first to provide an algorithm for potential candidates who may benefit from anti-IL-5Rα therapy...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27051309/step-down-therapy-in-well-controlled-asthmatic-patients-using-salmeterol-xinafoate-fluticasone-propionate-combination-therapy
#16
Kazuya Horiuchi, Keita Kasahara, Yusuke Kuroda, Haruna Morohoshi, Yosuke Hagiwara, Gen Ishii
PURPOSE: A combination therapy with inhaled corticosteroid (ICS) and a long-acting β agonist (LABA) is the standard treatment for asthmatic patients, and step-down treatment is recommended once control has been achieved. However, little data exist that evaluate the long-term outcomes after step-down treatment. OBJECTIVE: To compare the long-term outcomes of step-down therapy with ICS/LABA or ICS alone for asthmatic patients who have achieved well-controlled asthma by the ICS (250 µg fluticasone)/LABA (50 µg salmeterol) combination (SFC, two puffs per day)...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27051308/challenges-in-the-management-of-severe-allergic-asthma-in-the-elderly
#17
REVIEW
Ayse Bilge Ozturk, Sinem Iliaz
Little is known about the features of asthma and allergy in the elderly. A significant number of elderly patients with asthma have uncontrolled and severe asthma. This review aims to provide an analysis of the literature on the assessment and phenotype of severe allergic asthma in the elderly. Gaps and pitfalls in diagnostic and therapeutic approaches, as well as management of severe allergic asthma in the elderly, are also discussed.
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27042129/nasal-polyps-in-patients-with-asthma-prevalence-impact-and-management-challenges
#18
REVIEW
Cristobal Langdon, Joaquim Mullol
Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) often have coexisting asthma under the concept of "United Airway Disease", being the combination of both diseases, which is one of the most challenging phenotypes to treat. Although clinicians have recognized this difficult-to-treat phenotype for many years, it remained poorly characterized. There is increasing epidemiological evidence linking chronic rhinosinusitis and asthma, but a good understanding of the pathophysiology and the combined management is still lacking...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/27022293/aspirin-exacerbated-respiratory-disease-pathophysiological-insights-and-clinical-advances
#19
REVIEW
John W Steinke, Jeff M Wilson
Asthma and chronic rhinosinusitis are heterogeneous airway diseases of the lower and upper airways, respectively. Molecular and cellular studies indicate that these diseases can be categorized into unique endotypes, which have therapeutic implications. One such endotype is aspirin-exacerbated respiratory disease (AERD), which encompasses the triad of asthma, aspirin (or nonsteroidal anti-inflammatory drug) hypersensitivity, and nasal polyposis. AERD has unique pathophysiological features that distinguish it from aspirin-tolerant asthma and other forms of chronic rhinosinusitis...
2016: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/26929652/the-asthma-copd-overlap-syndrome-how-is-it-defined-and-what-are-its-clinical-implications
#20
Maarten van den Berge, René Aalbers
It is increasingly recognized that both asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with a large inter-individual variability with respect to their clinical expression, disease progression, and responsiveness to the available treatments. The introduction of asthma-COPD overlap syndrome (ACOS) may lead to a better clinical characterization and improved treatment of patients with obstructive airways disease. However, it is still in its early phase and several improvements will have to be made...
2016: Journal of Asthma and Allergy
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