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Clinical, Cosmetic and Investigational Dermatology

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https://www.readbyqxmd.com/read/28408849/a-retrospective-epidemiological-study-of-skin-diseases-among-pediatric-population-attending-a-tertiary-dermatology-referral-center-in-northern-greece
#1
Efstratios Vakirlis, Grigorios Theodosiou, Zoe Apalla, Michael Arabatzis, Elizabeth Lazaridou, Elena Sotiriou, Aimilios Lallas, Demetrios Ioannides
BACKGROUND: The incidence of skin diseases in children is influenced by hereditary, social, and environmental factors. The objective of this study was to determine the incidence of pediatric dermatoses at a University Hospital in Northern Greece. PATIENTS AND METHODS: We reviewed epidemiologic data of 940 patients, aged 0-18 years, who were referred to the outpatient clinic of a University Hospital between January 2013 and December 2015. Demographic data and the frequency of the various diagnoses in various age groups were studied...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28408848/ingenol-mebutate-in-low-amounts-for-the-treatment-of-actinic-keratosis-in-korean-patients
#2
Hyun Jae Joe, Byung Ho Oh
BACKGROUND: Ingenol mebutate (IM), a novel agent for field therapy of actinic keratosis (AK), has a drawback of inducing local skin reactions (LSRs), which may cause discomfort in patients. To reduce the LSRs, we tried the application of IM in low amounts. OBJECTIVE: The purpose of this study was to review Korean patients with AK being treated with IM and evaluate the LSRs and therapeutic outcomes of low amounts of IM. METHODS: We retrospectively reviewed 47 patients with AK on the face...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28331352/skin-disorders-in-parkinson-s-disease-potential-biomarkers-and-risk-factors
#3
REVIEW
Astrid-Helene Ravn, Jacob P Thyssen, Alexander Egeberg
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, characterized by a symptom triad comprising resting tremor, rigidity, and akinesia. In addition, non-motor symptoms of PD are well recognized and often precede the overt motor manifestations. Cutaneous manifestations as markers of PD have long been discussed, and cumulative evidence shows an increased prevalence of certain dermatological disorders in PD. Seborrheic dermatitis is considered to occur as a premotor feature of PD referable to dysregulation of the autonomic nervous system...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28280377/promotion-of-anagen-increased-hair-density-and-reduction-of-hair-fall-in-a-clinical-setting-following-identification-of-fgf5-inhibiting-compounds-via-a-novel-2-stage-process
#4
Dominic Burg, Masakuni Yamamoto, Masato Namekata, Joseph Haklani, Koichiro Koike, Maria Halasz
BACKGROUND: There are very few effective, scientifically validated treatments with known mechanisms of action for treatment of hair loss in both men and women. Fibroblast growth factor 5 (FGF5) is an important factor in the irreversible transition from anagen to catagen, and inhibition of FGF5 prolongs anagen phase and reduces hair loss. OBJECTIVE: We aimed to screen botanically derived molecules for FGF5 inhibitory activity in vitro and assess efficacy in a clinical setting...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28260938/superficial-basal-cell-carcinoma-treated-with-70-trichloroacetic-acid-applied-topically-a-case-study
#5
Anca Chiriac, Piotr Brzezinski, Cosmin Moldovan, Cristian Podoleanu, Marius Florin Coros, Simona Stolnicu
BACKGROUND: Basal cell carcinoma (BCC) is the most common form of skin cancer, affecting millions of people worldwide. The treatment concept for BCCs is the surgical one, but it is costly, as such, searching for alternative medical therapeutics is justified. AIM: To highlight the efficacy of high concentration (70%) trichloroacetic acid (TCA) as a choice therapy for low-risk BCC. METHOD AND PATIENT: Authors present, for the first time, the use of a high concentration TCA applied once a week for 2 consecutive weeks with a toothpick, on a patient with BCC on the right preauricular area...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28260937/the-role-of-inflammation-in-adipocytolytic-nonsurgical-esthetic-procedures-for-body-contouring
#6
REVIEW
Jonathas Xavier Pereira, Yuri Cavalcante, Riane Wanzeler de Oliveira
BACKGROUND: The adipocytolytic non-surgical esthetic procedures are indicated for the reduction of localized fat and are effective in reducing local adiposity through the ablation of adipocytes with fast and lasting results, besides causing local inflammation. OBJECTIVE: This study aimed to characterize the adipocytolytic procedures and correlate the phases of the inflammatory process with the results obtained from such procedures, in order to clarify the role of inflammation triggered by the adipocytolytic procedures and its relation with the lipolytic process, with a focus on body shaping...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28260936/microbiome-in-atopic-dermatitis
#7
REVIEW
Uwe Wollina
Atopic dermatitis (AD) is a common chronic inflammatory skin disease affecting ~10-20% of the general population. AD is characterized by disturbances in epidermal barrier function and hyperactive immune response. Recently, changes in the skin and intestinal microbiome have been analyzed in more detail. The available data suggest a link between disturbed skin microbiome and course of the disease. Flares of the disease are associated with an expansion of Staphylococcus aureus on lesional skin and a substantial loss of biodiversity in skin microbiome...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28243135/repeated-short-climatic-change-affects-the-epidermal-differentiation-program-and-leads-to-matrix-remodeling-in-a-human-organotypic-skin-model
#8
Laetitia-Barbollat Boutrand, Amélie Thépot, Charlotte Muther, Aurélie Boher, Julie Robic, Christelle Guéré, Katell Vié, Odile Damour, Jérôme Lamartine
Human skin is subject to frequent changes in ambient temperature and humidity and needs to cope with these environmental modifications. To decipher the molecular response of human skin to repeated climatic change, a versatile model of skin equivalent subject to "hot-wet" (40°C, 80% relative humidity [RH]) or "cold-dry" (10°C, 40% RH) climatic stress repeated daily was used. To obtain an exhaustive view of the molecular mechanisms elicited by climatic change, large-scale gene expression DNA microarray analysis was performed and modulated function was determined by bioinformatic annotation...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28203099/a-new-dermocosmetic-containing-retinaldehyde-delta-tocopherol-glucoside-and-glycylglycine-oleamide-for-managing-naturally-aged-skin-results-from-in-vitro-to-clinical-studies
#9
Céline Rouvrais, Daniel Bacqueville, Patrick Bogdanowicz, Marie-José Haure, Laure Duprat, Christine Coutanceau, Nathalie Castex-Rizzi, Hélène Duplan, Valérie Mengeaud, Sandrine Bessou-Touya
INTRODUCTION: Natural aging of skin tissues, the addition of the cumulative action of the time and radiation exposure result in skin atrophy, wrinkles and degeneration of the extracellular matrix (ECM). The aim of the study was to investigate the beneficial effect of a combination containing retinaldehyde (RAL), delta-tocopherol glucoside (delta-TC) and glycylglycine ole-amide (GGO) and of a dermocosmetic containing the combination. MATERIALS AND METHODS: The protective effect of the combination was assessed through in vitro gene expression of ultraviolet (UV)-irradiated fibroblasts...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28138262/clinical-efficacy-of-emollients-in-atopic-dermatitis-patients-relationship-with-the-skin-microbiota-modification
#10
Sophie Seité, Hana Zelenkova, Richard Martin
BACKGROUND: We speculated that an emollient supplemented with a biomass of nonpathogenic bacteria such as Vitreoscilla filiformis (Vf), grown in a medium containing thermal spring water (LRP-TSW); (LRP-Vitreoscilla filiformis biomass [LRP-VFB]), could have a beneficial effect for patients with atopic dermatitis (AD). PATIENTS AND METHODS: This double-blind, randomized, comparative study was conducted with 60 patients with moderate AD. Before starting the study, participants were pretreated for 15 days with drug therapy to improve their SCORing Atopic Dermatitis (SCORAD) by at least 25%...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28123311/cellulite-a-review-with-a-focus-on-subcision
#11
REVIEW
Daniel P Friedmann, Garrett Lane Vick, Vineet Mishra
Cellulite is an alteration in skin topography most often found on the buttocks and posterolateral thighs of the majority of postpubertal females. This article aims to review the background, potential pathophysiology, and potential treatment options for cellulite, highlighting subcision as an ideal therapeutic option for this cosmetically distressing condition.
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28123310/cosmeceutical-product-consisting-of-biomimetic-peptides-antiaging-effects-in-vivo-and-in-vitro
#12
Zarema I Gazitaeva, Anna O Drobintseva, Yongji Chung, Victoria O Polyakova, Igor M Kvetnoy
BACKGROUND: Biomimetic peptides are synthetic compounds that are identical to amino acid sequence synthesized by an organism and can interact with growth factor receptors and provide antiaging clinical effects. PURPOSE: The purpose of this study was to investigate the effects of biomimetic peptides on the repair processes in the dermis using a model of cell cultures and in vivo. PATIENTS AND METHODS: Five female volunteers were subjected to the injection of biomimetic peptides 1 month prior to the abdominoplasty procedure...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28115862/efficacy-of-a-twice-daily-3-step-over-the-counter-skincare-regimen-for-the-treatment-of-acne-vulgaris
#13
Katie Rodan, Kathy Fields, Timothy J Falla
BACKGROUND: Acne vulgaris (acne) is the most common skin disorder producing physical and emotional scars that can persist for years. An estimated 83% of acne sufferers self-treat, but there is lack of studies documenting the effectiveness of over-the-counter (OTC) acne treatment products. OBJECTIVE: This study was conducted to determine the effectiveness of an OTC, 3-step, anti-acne skincare regimen in treating acne and improving the appearance of red/inflamed facial skin...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28031724/erratum-aloe-sterol-supplementation-improves-skin-elasticity-in-japanese-men-with-sunlight-exposed-skin-a-12-week-double-blind-randomized-controlled-trial-corrigendum
#14
(no author information available yet)
[This corrects the article on p. 435 in vol. 9.].
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28008278/acne-keloidalis-nuchae-prevalence-impact-and-management-challenges
#15
REVIEW
Adebola Ogunbiyi
Acne keloidalis nuchae (AKN) also known as folliculitis keloidalis nuchae (FKN) is a chronic form of scarring folliculitis seen mostly in men of African descent. The term AKN is commonly used even though the condition is not a keloid, and the affected individuals do not have a tendency to develop keloids in other areas of the body. It is seen in post pubertal men and is rare after the age of 55 years. A few cases have been reported in females. which has been classified as a primary cicatricial alopecia since the exact cause of acne keloidalis (AK) remains unknown...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28003769/chronic-radiation-induced-dermatitis-challenges-and-solutions
#16
REVIEW
Mateusz Spałek
Chronic radiation dermatitis is a late side effect of skin irradiation, which may deteriorate patients' quality of life. There is a lack of precise data about its incidence; however, several risk factors may predispose to the development of this condition. It includes radiotherapy dose, fractionation, technique, concurrent systemic therapy, comorbidities, and personal and genetic factors. Chronic radiation dermatitis is mostly caused by the imbalance of proinflammatory and profibrotic cytokines. Clinical manifestation includes changes in skin appearance, wounds, ulcerations, necrosis, fibrosis, and secondary cancers...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27942228/reactivating-the-extracellular-matrix-synthesis-of-sulfated-glycosaminoglycans-and-proteoglycans-to-improve-the-human-skin-aspect-and-its-mechanical-properties
#17
Hanane Chajra, Daniel Auriol, Francine Joly, Aurélie Pagnon, Magda Rodrigues, Sophie Allart, Gérard Redziniak, Fabrice Lefevre
BACKGROUND: The aim of this study was to demonstrate that a defined cosmetic composition is able to induce an increase in the production of sulfated glycosaminoglycans (sGAGs) and/or proteoglycans and finally to demonstrate that the composition, through its combined action of enzyme production and synthesis of macromolecules, modulates organization and skin surface aspect with a benefit in antiaging applications. MATERIALS AND METHODS: Gene expression was studied by quantitative reverse transcription polymerase chain reaction using normal human dermal fibroblasts isolated from a 45-year-old donor skin dermis...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27920565/electrochemotherapy-induces-apoptotic-death-in-melanoma-metastases-a-histologic-and-immunohistochemical-investigation
#18
Laura Bigi, Giovanna Galdo, Anna Maria Cesinaro, Cristina Vaschieri, Alessandra Marconi, Carlo Pincelli, Fabrizio Fantini
BACKGROUND: Electrochemotherapy (ECT) is increasingly used in the treatment of primary and secondary skin tumors, but little is known about the pathologic mechanism responsible for tumor cell destruction in humans. Knowledge of detailed mechanism of host response after ECT may improve the treatment efficacy related to patient selection and technique refinements. AIM: The aim of the study was to investigate the histopathology and mechanism of cell death after ECT in cutaneous melanoma metastases...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27877062/systemic-abnormalities-of-psoriatic-patients-a-retrospective-study
#19
Li Yin, Jia-Li Xu, Ying-Ying Hu, Andrew Johnston, Zhi-Qiang Yin
BACKGROUND: Psoriasis is a chronic immune-mediated inflammatory disease related to the metabolic syndrome, cardiovascular disease, and other comorbidities. However, so far there has been no specific research concerning systemic abnormalities in psoriatic patients. OBJECTIVE: A retrospective study was conducted focusing on the detailed systemic abnormalities in psoriatic patients. METHODS: Psoriatic inpatients data was collected from July 2009 to September 2015...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27877061/aloe-sterol-supplementation-improves-skin-elasticity-in-japanese-men-with-sunlight-exposed-skin-a-12-week-double-blind-randomized-controlled-trial
#20
Miyuki Tanaka, Yuki Yamamoto, Eriko Misawa, Kazumi Nabeshima, Marie Saito, Koji Yamauchi, Fumiaki Abe, Fukumi Furukawa
BACKGROUND/OBJECTIVE: Recently, it was confirmed that the daily oral intake of plant sterols of Aloe vera gel (Aloe sterol) significantly increases the skin barrier function, moisture, and elasticity in photoprotected skin. This study aimed to investigate whether Aloe sterol intake affected skin conditions following sunlight exposure in Japanese men. METHODS: We performed a 12-week, randomized, double-blind, placebo-controlled study to evaluate the effects of oral Aloe sterol supplementation on skin conditions in 48 apparently healthy men (age range: 30-59 years; average: 45 years)...
2016: Clinical, Cosmetic and Investigational Dermatology
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