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Clinical, Cosmetic and Investigational Dermatology

Flávia Alvim Sant'Anna Addor, Ludmila Coelho Donato, Camila Sirieiro Abreu Melo
Purpose: Telogen effluvium (TE) is defined as a diffuse hair loss characterized by shortening of the anagen phase and precipitation of the telogen phase, with a consequent reduction of total hair volume. Nutritional supplementation is indicated under conditions in which TE is related to dietary disorders. The aim of this clinical study was to compare the efficacy of two different supplements in monotherapy for TE. Patients and methods: Female adult patients were randomized to receive two oral nutritional supplements (group 1: a supplement composed of zinc, biotin, iron, vitamins A, C, E, and B complex, folic acid, magnesium, and amino acids of keratin and collagen and group 2: calcium pantothenate cystine, thiamine nitrate, medicinal yeast, keratin, and aminobenzoic acid) to treat hair loss for 180 days...
2018: Clinical, Cosmetic and Investigational Dermatology
Hélène Hernandez-Pigeon, Lucile Garidou, Marie-Florence Galliano, Hélène Delga, Marie-Françoise Aries, Hélène Duplan, Sandrine Bessou-Touya, Nathalie Castex-Rizzi
Background: Rosacea is a chronic facial skin disorder characterized by inflammation and vascular abnormalities. The pathophysiology of rosacea involves increased activation of the capsaicin receptor, TRPV1, the vascular endothelial growth factor (VEGF) pathway, and cathelicidin LL-37, MMP-9, and KLKs. We evaluated the activity of four compounds (dextran sulfate, 4-t-butylcyclohexanol [BCH; TRP-regulin® ], pongamia oil, and hesperidin methyl chalcone [HMC]) on inflammatory and vascular responses implicated in rosacea...
2018: Clinical, Cosmetic and Investigational Dermatology
Heba H El-Hadidi, Akmal S Hassan, Ghada El-Hanafy, Khalda S Amr, Sameh F Abdelmesih, Mahmoud F Abdelhamid
Background: Increased transforming growth factor beta 1 (TGF-β1) in the epidermis and serum has been found in psoriatic patients. The mechanism for this increase remains unclear. Objective: To study the TGF-β1 gene polymorphism at codon 10 and its relation to psoriasis susceptibility in a sample of Egyptian patients. Materials and methods: This cross-sectional study involved 70 patients with psoriasis vulgaris and 100 age- and sex- comparable healthy volunteers as a control group...
2018: Clinical, Cosmetic and Investigational Dermatology
Nupur U Patel, Catherine Roach, Hossein Alinia, William W Huang, Steven R Feldman
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. While the goal of therapy is to treat the primary cause, cosmetic resolution of AN lesions can be important for patients and their quality of life...
2018: Clinical, Cosmetic and Investigational Dermatology
Bruno Gualtieri, Annalisa Tonini, Salvatore Panduri, Andrea Chiricozzi, Marco Romanelli
Acne fulminans (AF) is a rare acne variant characterized by sudden onset of painful nodules on the face, chest, and back in the presence of systemic symptoms. Pharmacologic agents such as steroid hormones and isotretinoin are well-known triggers, and several cases have been described. We report a case of AF occurring a few days after lymecycline therapy initiation.
2018: Clinical, Cosmetic and Investigational Dermatology
Vittorio Mazzarello, Marco Ferrari, Pasquale Ena
Background: Werner syndrome (WS) is a rare autosomal recessive disorder characterized by premature aging in adults. Although not sufficient to diagnose WS, persistent short stature and alteration of the dentition are among the few early signs that appear at puberty and can lead to a suspected diagnosis. Objective: The study aimed at quantifying the signs of WS skin aging through biophysical parameters to find new parameters to be applied together with clinical observations in order to diagnose the disease early...
2018: Clinical, Cosmetic and Investigational Dermatology
Marco Morelli Coppola, Rosa Salzillo, Francesco Segreto, Paolo Persichetti
Keloids are pathological scars presenting as nodular lesions that extend beyond the area of injury. They do not spontaneously regress, often continuing to grow over time. The abnormal wound-healing process underlying keloid formation results from the lack of control mechanisms self-regulating cell proliferation and tissue repair. Keloids may lead to cosmetic disfigurement and functional impairment and affect the quality of life. Although several treatments were reported in the literature, no universally effective therapy was found to date...
2018: Clinical, Cosmetic and Investigational Dermatology
Reza Bidaki, Niloofar Majidi, Amir Moghadam Ahmadi, Hamid Bakhshi, Rezvan Sadr Mohammadi, Seyed-Ali Mostafavi, Mohammad Kazemi Arababadi, Maryam Hadavi, Afshin Mirzaei
Background and aim: Vitiligo is a chronic skin disease characterized by a total or partial loss of melanocytes from the epidermis and other tissues of the skin. It is placed in the class of secondary psychiatric disorders and can also lead to psychological problems. The main aim of this study was to assess social acceptance in vitiligo patients. Methods: This cross-sectional study was conducted on all of the patients (n=150) with vitiligo who were referred to dermatology clinics in Rafsanjan, Iran...
2018: Clinical, Cosmetic and Investigational Dermatology
Virginie Ribet, Ewa Mielewczyk, Anne Sirvent, Victor Georgescu, Ana Beatris Rossi
Background: The regular use of cosmetic products plays a role in the management of hand eczema (HE) and aids in improving barrier function reducing dryness, roughness, pruritus and improving quality of life (QoL). The aim of this open-label study was to assess the efficacy and the reparative effect of a dermo-cosmetic product on subjects suffering from HE after 7 and 21 days of daily application. Methods: The product was a water-in-oil (W/O) emulsion containing the active ingredients Avène thermal spring water, sucralfate, and copper and zinc sulfates...
2018: Clinical, Cosmetic and Investigational Dermatology
David E Castillo, Jonette E Keri
Acne vulgaris is the most common skin disorder in adolescents and young adults. It carries a significant psychological and economic burden to patients and society. A wide range of therapeutic options are available, including topicals and systemic therapies. Chemical peeling is a skin resurfacing procedure intended to regenerate normal skin from the application of exfoliative agents. It has been used for the treatment of acne vulgaris and other skin disorders for decades. There are several chemical agents with variable mechanisms of action, usually classified as superficial, medium, and deep peels...
2018: Clinical, Cosmetic and Investigational Dermatology
Yates Yy Chao, Jong Woo Kim, JongSeo Kim, Hyungseok Ko, Kate Goldie
With their high elasticity and viscosity, calcium hydroxylapatite (CaHA) fillers are now widely used to treat age-related or hereditary facial soft tissue volume deficits. CaHA filler volume augmentation is further enhanced by its ability to stimulate neocollagenesis and improve skin quality. However, its high viscosity and cohesivity may hinder its spread and distribution, while its injection by cannula or needle may require moderate extrusion force and lead to uneven distribution or focal accumulation in tissues...
2018: Clinical, Cosmetic and Investigational Dermatology
Andreas Nikolis, Kaitlyn M Enright, Sofia Masouri, Steven Bernstein, Christina Antoniou
Background: IncobotulinumtoxinA (Xeomin Cosmetic® ) has been used previously in the management of masseteric hypertrophy. However, a standardized injection technique has not been established. The goal of the present study was to evaluate the efficacy and safety of two injection techniques in the management of masseteric hypertrophy using incobotulinumtoxinA. Methods: Thirty female patients with masseteric hypertrophy were recruited and evenly randomized to receive bilateral treatments of either a single-injection technique (SIT) or a multiinjection technique (MIT)...
2018: Clinical, Cosmetic and Investigational Dermatology
Filomena Merola, Mario Scrima, Carmela Melito, Antonio Iorio, Claudio Pisano, Andrea Maria Giori, Angela Ferravante
Background: Hyaluronic acid (HA)-based devices are among the most popular filler agents for skin rejuvenation. One of the principal goals is the improvement in residence time of HA-based products, to increase their performance and reduce frequency of the treatment. So, understanding fillers, behavior after subcutaneous injection is a fundamental aspect for discovery and optimization of new products. Current in vivo approaches to detect/quantify injected HA fillers are not always well optimized or easy to apply...
2018: Clinical, Cosmetic and Investigational Dermatology
Adeolu Oladayo Akinboro, David Adekunle Onilede, Taiwo Olabimpe Babatunde, Sebastine Oseghae Oiwoh, Oreoluwa Adeola Suleiman, Olatunde Peter Olabode
Introduction: Idiopathic scrotal calcinosis is a benign and rare disease of the scrotal skin that presents as solitary or multiple asymptomatic calcified nodules in the absence of systemic disorders of calcium/phosphorus balance. Case reports: We report the management of 2 cases and review the literature with comments on factors that determine acceptance or otherwise of surgical treatment. Our patients were 29 and 33 years old and presented with nodular scrotal lesions...
2018: Clinical, Cosmetic and Investigational Dermatology
Jürgen Frevert, Ki Young Ahn, Mee Young Park, Owen Sunga
Results: All protein-based therapeutics, such as botulinum neurotoxin type A (BoNT/A), are potentially immunogenic and can lead to anaphylaxis, autoimmunity, or diminished or complete absence of therapeutic efficacy, especially if administered repeatedly. Therefore, the protein quantity in BoNT/A products is an important consideration when selecting products for treatment. However, essential formulation data are not always publicly accessible. Materials and methods: The neurotoxin protein content of products newly introduced in Asia, such as (listed alphabetically) Botulax® , Meditoxin® , Nabota® , and Relatox® , was measured by sandwich enzyme-linked immunosorbent assay with antisera directed against BoNT/A compared to Xeomin® ...
2018: Clinical, Cosmetic and Investigational Dermatology
Rowland Noakes
Background: Scleroderma is traditionally managed with immunomodulatory agents such as methotrexate, mycophenolate mofetil and corticosteroids. There are anecdotal reports for, and theoretical reasons why, the anti-fibrotic agent tranilast may provide an additional treatment modality. Objective: The objective of the current study was to demonstrate if the addition of topical tranilast to an established regime resulted in an improvement in the Localized Scleroderma Assessment Tool (LoSCAT) and modified Rodnan score...
2018: Clinical, Cosmetic and Investigational Dermatology
Derek Beaulieu, Ramin Fathi, Divya Srivastava, Rajiv I Nijhawan
Mohs micrographic surgery (MMS), a specialized surgical excision technique used primarily in the treatment of skin cancers, is tissue sparing and provides optimal margin control through evaluation of 100% of both the peripheral and deep margin. The use of MMS for the treatment of malignant melanoma (MM) and melanoma in situ (MIS) has been slow in gaining the same widespread acceptance that it has for keratinocyte carcinomas despite its cost-effectiveness and the growing body of evidence demonstrating similar or improved cure rates to standard wide local excision...
2018: Clinical, Cosmetic and Investigational Dermatology
Ewa Markiewicz, Olusola Clement Idowu
Human skin is a stratified endocrine organ with primary roles in protection against detrimental biochemical and biophysical factors in the environment. Environmental stress causes gradual accumulation of the macromolecular damage and clinical manifestations consistent with chronic inflammatory conditions and premature aging of the skin. Structural proteins of cell nucleus, the nuclear lamins and lamina-associated proteins, play an important role in the regulation of a number of signal transduction pathways associated with stress...
2018: Clinical, Cosmetic and Investigational Dermatology
Eman Salah
Background: Extragenital warts (E-GWs) are common benign skin lesions caused by human papilloma virus. Surprisingly, there is no clear data about the impact of multiple E-GWs on quality of life in immune-competent adult patients in comparison to GWs, which have been frequently reported to exhibit a strong negative impact on life quality. Patients and methods: This cross-sectional study investigated the impact of multiple E-GWs on quality of life in immune-competent adults as they are more commonly encountered in daily practice than their genital counterpart in the Egyptian population...
2018: Clinical, Cosmetic and Investigational Dermatology
Souphiyeh Samizadeh, Koenraad De Boulle
Botulinum toxin A is produced by anaerobic spore-forming bacteria and is used for various therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular nonsurgical procedure worldwide. Despite an increased demand for botulinum toxin A injections, the clinical pharmacology and differences in formulation of commonly available products are poorly understood. The various products available in the market are unique and vary in terms of units, chemical properties, biological activities, and weight, and are therefore not interchangeable...
2018: Clinical, Cosmetic and Investigational Dermatology
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