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Clinical, Cosmetic and Investigational Dermatology

Adeolu Oladayo Akinboro, Ogochukwu Ifeanyi Ezejiofor, Fatai Olatunde Olanrewaju, Mufutau Muphy Oripelaye, Olatunde Peter Olabode, Olugbenga Edward Ayodele, Emmanuel Olaniyi Onayemi
Background: Acne and facial post-inflammatory hyperpigmentation are relatively common clinical conditions among adolescents and young adults, and inflict psychosocial injuries on sufferers. Objective: To document the psychosocial and self-esteem implications of acne and facial hyperpigmentation on newly admitted undergraduates. Materials and methods: A cross-sectional survey was conducted among 200 undergraduates. Demographics and clinical characteristics were obtained and acne was graded using the US Food and Drug Administration 5-category global system of acne classification...
2018: Clinical, Cosmetic and Investigational Dermatology
Hamid Reza Ghasemi Basir, Pedram Alirezaei, Zahra Hamian, Elham Khanlarzadeh
Background: There are overlapping features in histopathologic characteristics of psoriasis and chronic dermatitis, which sometimes make the correct diagnosis difficult. Objective: The aim of this study was to compare the histopathologic diagnostic features of psoriasis with chronic dermatitis quantitatively. Patients and methods: In this study, 30 patients with psoriasis and 30 patients with chronic dermatitis were included. Diagnosis of psoriasis or chronic dermatitis was based on clinicopathologic correlation...
2018: Clinical, Cosmetic and Investigational Dermatology
Daniel Barolet, Antranik Benohanian
Background: Jet injection can be defined as a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers a drug. Despite 75 years of existence, it never reached its full potential as a strategic tool to deliver medications through the skin. Objective: The aim of this review was to evaluate and summarize the evolution of jet injection intradermal drug delivery method including technological advancements and new indications for use...
2018: Clinical, Cosmetic and Investigational Dermatology
Rajiv Joshi, Khushboo Minni
Porokeratosis is an uncommon disorder of keratinization that presents with keratotic papules or annular plaques that expand centrifugally with a thread-like elevated border. A distinctive histologic structure, the cornoid lamella, is diagnostic of this disorder and consists of a column of parakeratosis with the absence of the granular layer and dyskeratotic cells in the upper spinous zone. Porokeratosis confined to the genitogluteal region is rare and may be subclassified into three types, namely, classical porokeratosis on the genital region, ptychotropic porokeratosis most often seen in the natal cleft and buttocks and penoscrotal porokeratosis that is seen on the penis and adjacent scrotal skin in young men in their third decade of life...
2018: Clinical, Cosmetic and Investigational Dermatology
Stephanie J Nisbet
Purpose: This 3-week, open-label, noncomparative clinical study evaluated the skin acceptability of a cosmetic moisturizer in subjects with sensitive skin, by monitoring adverse events (AEs) and cutaneous discomfort related to normal usage. Materials and methods: Female subjects aged between 18-60 years, with Fitzpatrick phototype classification I-IV and sensitive skin, verified by a positive reaction on the stinging test at screening, were included. Subjects applied the moisturizer to their face and body twice daily for 21±2 days at home and recorded study product usage and feelings of cutaneous discomfort (eg, dryness, prickling, stinging, and itching) in a diary; any AEs were reported to the clinic...
2018: Clinical, Cosmetic and Investigational Dermatology
Flávia Alvim Sant'Anna Addor, Juliana Cotta Vieira, Camila Sirieiro Abreu Melo
Purpose: Skin aging is a progressive and degenerative process caused by a decrease in the physiological functions of the skin tissue. In addition, environmental factors as well as concomitant diseases and lifestyle (nutrition, sedentary lifestyle, smoking, etc) negatively impact the aging process. An association between oral administration of collagen peptides combined with vitamin C and extracts of Hibiscus sabdariffa and Aristotelia chilensis (Delphynol® ) (Eximia Firmalize Age complex® ) on dermal thickness was studied and the improvement in aging signs was evaluated...
2018: Clinical, Cosmetic and Investigational Dermatology
Vivianne Carvalho Canela, Cinthia Nicoletti Crivelaro, Luciane Zacchi Ferla, Gisele Marques Pelozo, Juliana Azevedo, Richard Eloin Liebano, Caroline Nogueira, Renata Michelini Guidi, Clóvis Grecco, Estela Sant'Ana
Background and objectives: Nowadays, there are several noninvasive technologies being used for improving of body contouring. The objectives of this pilot study were to verify the effectiveness of the Heccus® device, emphasizing the synergism between nonfocused ultrasound plus Aussie current in the improvement of body contour, and to determine if the association of this therapy with whole-body vibration exercises can have additional positive effects in the results of the treatments. Subjects and methods: Twenty healthy women aged 20-40 years participated in the study...
2018: Clinical, Cosmetic and Investigational Dermatology
Hessah F BinJadeed, Alanoud M Alyousef, Fahad M Alsaif, Ahmed A Alhumidi, Homaid O Alotaibi
Background: Autoimmune subepidermal bullous dermatoses have similar clinical features to those of a spectrum of immune reactants at the dermoepidermal junction (DEJ). It is difficult to obtain a precise diagnosis without an immunofluorescence assay because of their similar clinical presentations. The aim of this study was to describe the cellular cutaneous infiltration among autoimmune subepidermal bullous dermatoses. Materials and methods: This retrospective analysis was conducted at a hospital in Riyadh, Saudi Arabia using biopsy-based data collected from 65 patients...
2018: Clinical, Cosmetic and Investigational Dermatology
Ahmet Metin, Nursel Dilek, Serap Gunes Bilgili
Intertrigo is a common inflammatory dermatosis of opposing skin surfaces that can be caused by a variety of infectious agents, most notably candida, under the effect of mechanical and environmental factors. Symptoms such as pain and itching significantly decrease quality of life, leading to high morbidity. A multitude of predisposing factors, particularly obesity, diabetes mellitus, and immunosuppressive conditions facilitate both the occurrence and recurrence of the disease. The diagnosis of candidal intertrigo is usually based on clinical appearance...
2018: Clinical, Cosmetic and Investigational Dermatology
Aryan Maleki, Noorulain Khalid
No abstract text is available yet for this article.
2018: Clinical, Cosmetic and Investigational Dermatology
Ewa Markiewicz, Olusola Clement Idowu
Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organization and compartmentalized sensitivity to distinct extrinsic aging factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of drug absorption, sensitization and other longer term effects...
2018: Clinical, Cosmetic and Investigational Dermatology
Victoria Billero, Mariya Miteva
Traction alopecia (TA) affects one-third of women of African descent who wear various forms of traumatic hairstyling for a prolonged period of time. The risk of TA is increased by the extent of pulling and duration of traction, as well as the use of chemical relaxation. The frequent use of tight buns or ponytails, the attachment of weaves or hair extensions, and tight braids (such as cornrows and dreadlocks) are believed to be the highest risk hairstyles. TA can also occur in the setting of religious and occupational traumatic hairstyling...
2018: Clinical, Cosmetic and Investigational Dermatology
Yutaka Takagi, Xuanhe Ning, Akihiko Takahashi, Chiaki Ishizaki, Takahiro Nishizaka, Kazuhiro Kaizu, Masahiro Miyaki, Hotaka Yamamuro, Makoto Kawashima
Objective: Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases. Methods: Thirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects)...
2018: Clinical, Cosmetic and Investigational Dermatology
Adel Alsantali
Background: Botulinum toxin is a safe and effective therapy for palmar hyperhidrosis, but the associated pain from injections limits the usefulness of this method of treatment. Purpose: To evaluate the efficacy of Eutectic Mixture of Local Anesthetics (EMLA) cream versus ice application in alleviation of pain during botulinum toxin injections for palmar hyperhidrosis. Methods: In this prospective study, 23 patients underwent palm Botox injections to treat their excessive sweating...
2018: Clinical, Cosmetic and Investigational Dermatology
Evellyn Claudia Wietzikoski Lovato, Patrícia Amaral Gurgel Velasquez, Cristiana Dos Santos Oliveira, Camila Baruffi, Thais Anghinoni, Raquel Costa Machado, Francislaine Aparecida Dos Reis Lívero, Samantha Wietzikoski Sato, Lisiane de Almeida Martins
Background: The indiscriminate use of antibiotics has caused bacteria to develop mechanisms of resistance to antibacterial agents, limiting treatment options. Therefore, there is a great need for alternative methods to control infections, especially those related to skin. One of the alternative methods is the high frequency equipment (HFE), which is used on skin conditions as an analgesic, an anti-inflammatory, and mainly to accelerate cicatricial processes and have a bactericidal effect through the formation of ozone...
2018: Clinical, Cosmetic and Investigational Dermatology
Hamid Reza Ghasemi Basir, Pedram Alirezaei, Sara Ahovan, Abbas Moradi
Background: Malignant melanoma of the skin is a potentially lethal neoplasm that generally originates from atypical melanocytes in the dermal-epidermal junction. When the neoplasm penetrates into the dermis, several variables can affect the extent of its spread, among which depth of invasion has the most important prognostic value. Mitotic rate is another prognostic factor that reflects the biological behavior of the neoplasm. Objective: This study was designed to evaluate the probable relationship between the depth of invasion of malignant melanoma and its mitotic rate...
2018: Clinical, Cosmetic and Investigational Dermatology
Yoshihiko Sugihara, Shigehito Ikushima, Mika Miyake, Takayoshi Kirisako, Yukihiro Yada, Daisuke Fujiwara
Purpose: The present study examined the effect of ingestion of Koji extract containing 14-dehydroergosterol (14-DHE), prepared from Aspergillus kawachii NBRC4308, on improvement of skin conditions among healthy volunteers. Subjects and methods: In a randomized, double-blind, placebo-controlled, parallel-group study, 70 healthy adult women who felt that their skin was dry ingested either a placebo dietary supplement or Koji extract (200 mg/day) supplement containing 0...
2018: Clinical, Cosmetic and Investigational Dermatology
Luca Giacomelli, Stefano Togni, Martino Meneghin, Roberto Eggenhöffner, Giada Maramaldi
Purpose: The purpose of this in vivo study is to evaluate the acute clinical application of a multicomponent powder (Vitachelox® ), including three naturally occurring standardized extracts rich in polyphenols (grape seed extract, green tea extract, oak wood/bark extract), on healthy volunteers by measuring prevention of any metal deposition within the stratum corneum (SC) following a 6-h exposure period in a polluted environment. Patients and methods: In this in vivo study, we evaluated the skin protective activity of the multicomponent powder formulated in a base emulsion compared to a relevant placebo cream...
2018: Clinical, Cosmetic and Investigational Dermatology
Monika Heisig, Adam Reich
Background: Rosacea is a common, chronic skin condition characterized by facial redness and inflammatory lesions. The disease can lead to social stigmatization and may significantly reduce the quality of life of patients. Psychosocial impact of rosacea can be severe and debilitating; however, it is still underestimated. Objective: This paper provides a literature review focused on depression and anxiety in patients with rosacea. Conclusion: Rosacea patients have an increased risk of developing depression and anxiety and tend to avoid social situations...
2018: Clinical, Cosmetic and Investigational Dermatology
Enzo Errichetti, Matteo Figini, Margherita Croatto, Giuseppe Stinco
Several treatment strategies have been proposed in classic lichen planopilaris (LPP), although no gold standard therapeutic approach has been recognized so far due to the variable and, sometimes, contradictory results reported in the literature, as well as due to the lack of guidelines and randomized controlled trials. In the present review, we sought to provide an updated overview on the treatment of classic LPP by analyzing the level of evidence of published studies, also proposing a possible therapeutic strategy according to the findings highlighted in this systematic review...
2018: Clinical, Cosmetic and Investigational Dermatology
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