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Clinical, Cosmetic and Investigational Dermatology

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https://www.readbyqxmd.com/read/30425546/regularities-of-free-radical-processes-and-involutional-changes-of-face-and-neck-skin-in-different-age-groups
#1
E V Silina, V A Stupin, S B Bolevich, N E Manturova
Aim: The purpose of this study was to examine the role of free radical oxygen and peroxide- lipid processes along with conducting the study of blood flow level and oxygen saturation of facial tissues in patients of different ages with varying degrees of involutional changes in the skin of the face and neck. Materials and methods: One hundred and fifty-three people (84.3% women and 15.7% men) aged from 26 to 78 years with varying degrees of involutional changes in facial skin were examined...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30410380/potential-protective-effects-of-rhegf-against-ultraviolet-a-irradiation-induced-damages-on-human-fibroblasts
#2
Ji Min Kim, Jung Eun Choo, Ki Nam Kim, Yang Seok Kim
Background: Ultraviolet A (UVA) rays reach the dermal skin layer and generate oxidative stress, DNA damage, and cell inflammation, which in turn lead to photo-aging and photo-carcinogenesis. While there have been many studies about the beneficial effects of topical epidermal growth factor (EGF) treatment in the healing of wounds, the effect of EGF on UVA-induced skin irritation remains unknown. To clarify the effects of EGF on UVA-induced skin damage, it was investigated whether EGF signaling can affect intracellular reactive oxygen species (ROS) and DNA damages in UVA-irradiated human dermal fibroblasts...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30410379/cryolipolysis-patient-selection-and-special-considerations
#3
REVIEW
Patricia Froes Meyer, Julio Davi Costa E Silva, Liliane Santos de Vasconcellos, Eneida de Morais Carreiro, Rodrigo Marcel Valentim da Silva
Cryolipolysis is considered a safe and effective procedure, with high patient satisfaction rates, especially when compared to other procedures for localized adiposity, such as high-intensity focused ultrasound and shock waves. Although this statement is present in the literature, the importance of the selection of suitable patients for this type of treatment is not well known. The objective of this study was to discuss the criteria to be considered in the selection of patients who are candidates for cryolipolysis and assess their profile regarding their anthropometric data, age, skin characteristics, cutaneous sensitivity, and risk pathologies for this type of treatment...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30410378/skin-hydration-is-significantly-increased-by-a-cream-formulated-to-mimic-the-skin-s-own-natural-moisturizing-systems
#4
Fabrizio Spada, Tanya M Barnes, Kerryn A Greive
Background: Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin. Materials and methods: A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin's own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin, and compared to three reference moisturizers available over-the-counter, and placebo...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30349346/effects-of-topical-0-8-piroxicam-and-50-sunscreen-filters-on-actinic-keratosis-in-hypertensive-patients-treated-with-or-without-photosensitizing-diuretic-drugs-an-observational-cohort-study
#5
Sara Mazzilli, Virginia Garofalo, Alessandra Ventura, Laura Diluvio, Massimo Milani, Luca Bianchi, Elena Campione
Background: Photosensitizing diuretics use (especially thiazide compounds) is associated with a significantly higher risk of squamous cell carcinoma (SCC). Actinic keratosis (AK) is a precursor of SCC. Study aim: To evaluate in a prospective cohort study the efficacy of topical piroxicam 0.8% and sunscreen 50+ (ACTX) in the treatment of AK in hypertensive subjects with or without TD treatment. Subjects and methods: A total of 119 hypertensive subjects with multiple AK (39 under chronic TD treatment; and 80 treated with other non-TD, non-photosensitizing antihypertensive drugs) were enrolled after their informed consent in a 6-month observational cohort study...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30349345/genetic-polymorphism-analysis-of-patients-with-primary-hyperhidrosis
#6
Bryce C Simes, Joshua P Moore, Terry C Brown, Tyler J Rushforth, Angela L Bookout, Chante L Richardson
Background: Hyperhidrosis affects 220 million people worldwide. The hallmark of this condition is excessive sweating, which negatively impacts the social, emotional, and occupational lives of these individuals. A familial predisposition has been established; however, the specific genes involved have yet to be identified. Objective: The aim of this study was to determine possible genetic variations contributing to primary hyperhidrosis, specifically single-nucleotide polymorphisms (SNPs)...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30349344/evaluating-the-role-of-small-particle-hyaluronic-acid-fillers-using-micro-droplet-technique-in-the-face-neck-and-hands-a-retrospective-chart-review
#7
Andreas Nikolis, Kaitlyn M Enright
Background: Loss of the viscoelastic properties of the skin is a primary sign of aging and contributes to the appearance of wrinkles. Hyaluronic acid (HA) fillers are one of the most commonly used treatments for age-related soft-tissue reduction and volume loss. Evidence is also emerging that HA fillers rejuvenate the skin. Methods: A retrospective chart review was completed on 20 subjects treated with small particle HA (SP-HA), to investigate its effects on skin properties...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30349343/can-emollients-of-similar-composition-be-assumed-to-be-therapeutically-equivalent-a-comparison-of-skin-occlusivity-and-emulsion-microstructure
#8
Milan D Antonijević, Ovidiu Novac, Barry Mg O'Hagan
Introduction: Emollient therapy is the mainstay for treating skin conditions such as atopic dermatitis and psoriasis. New emollients have been introduced recently and are assumed to be therapeutically interchangeable with the innovator products because, superficially, they appear to have similar compositions. This study compares a) the ex vivo human skin occlusion performance and b) the visual and microscopic properties of Isomol gel (IMG) and Doublebase gel (DBG). Materials and Methods: Occlusion was measured gravimetrically by reduction in cumulative 48-hour evaporative weight loss from ex vivo human skin samples following single applications of the two test emollients and Vaseline® ...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30349342/calcipotriol-betamethasone-dipropionate-aerosol-foam-for-the-treatment-of-psoriasis-vulgaris-case-series-and-review-of-the-literature
#9
Andreas Pinter, Henrik Thormann, Flavia Angeletti, Ahmad Jalili
An aerosol foam formulation of a once-daily, fixed-dose combination of a synthetic vitamin D3 analog/synthetic corticosteroid (calcipotriol [Cal] 50 µg/g and betamethasone dipropionate [BD] 0.5 mg/g) has recently been introduced for the topical treatment of plaque psoriasis in adults. Data from several sources - randomized controlled trials, case reports (as highlighted in this review), and real-world evidence (RWE) - underscore the considerable and rapid clinical response, effectiveness, and favorable safety and tolerability of Cal/BD aerosol foam in mild-to-moderate psoriatic patients previously treated with class 3 or 4 topical corticosteroids, in patients unsatisfied with ongoing phototherapy in combination with topical therapy and in patients with moderate-to-severe psoriasis...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30349341/effects-of-oral-supplementation-with-fos-and-gos-prebiotics-in-women-with-adult-acne-the-s-o-sweet-study-a-proof-of-concept-pilot-trial
#10
Federica Dall'Oglio, Massimo Milani, Giuseppe Micali
Background: We evaluated the effects of 3-month prebiotic oral supplementation with fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS) on glucose and lipid metabolic parameters in women with adult acne (female adult acne). Methods: Twelve women, mean age 35 years, with mild to moderate acne were enrolled. Exclusion criteria were severe acne, body mass index (BMI) >25, history of diabetes mellitus, polycystic ovary syndrome, regular intake of prebiotics or probiotics, and history of inflammatory intestinal diseases...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30288075/beyond-photoaging-additional-factors-involved-in-the-process-of-skin-aging
#11
REVIEW
Flavia Alvim Sant'Anna Addor
Studies assessing the impact of extrinsic factors on skin aging have increased during the last with the increase in life expectancy. Although most of the studies are about the sun radiation impact, many factors should be considered in elderly people, beyond environmental conditions. Lifestyle factors, like diet, sleeping, smoking, should be analyzed carefully, as common age-related conditions (menopause, diabetes, pulmonary diseases, etc.). All these factors could accelerate the natural decline of skin structure and functions, possibly affecting the responses to treatments and drugs...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30237729/comparative-evaluation-between-two-nutritional-supplements-in-the-improvement-of-telogen-effluvium
#12
Flávia Alvim Sant'Anna Addor, Ludmila Coelho Donato, Camila Sirieiro Abreu Melo
Purpose: Telogen effluvium (TE) is defined as a diffuse hair loss characterized by shortening of the anagen phase and precipitation of the telogen phase, with a consequent reduction of total hair volume. Nutritional supplementation is indicated under conditions in which TE is related to dietary disorders. The aim of this clinical study was to compare the efficacy of two different supplements in monotherapy for TE. Patients and methods: Female adult patients were randomized to receive two oral nutritional supplements (group 1: a supplement composed of zinc, biotin, iron, vitamins A, C, E, and B complex, folic acid, magnesium, and amino acids of keratin and collagen and group 2: calcium pantothenate cystine, thiamine nitrate, medicinal yeast, keratin, and aminobenzoic acid) to treat hair loss for 180 days...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30233225/effects-of-dextran-sulfate-4-t-butylcyclohexanol-pongamia-oil-and-hesperidin-methyl-chalcone-on-inflammatory-and-vascular-responses-implicated-in-rosacea
#13
Hélène Hernandez-Pigeon, Lucile Garidou, Marie-Florence Galliano, Hélène Delga, Marie-Françoise Aries, Hélène Duplan, Sandrine Bessou-Touya, Nathalie Castex-Rizzi
Background: Rosacea is a chronic facial skin disorder characterized by inflammation and vascular abnormalities. The pathophysiology of rosacea involves increased activation of the capsaicin receptor, TRPV1, the vascular endothelial growth factor (VEGF) pathway, and cathelicidin LL-37, MMP-9, and KLKs. We evaluated the activity of four compounds (dextran sulfate, 4-t-butylcyclohexanol [BCH; TRP-regulin® ], pongamia oil, and hesperidin methyl chalcone [HMC]) on inflammatory and vascular responses implicated in rosacea...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30174452/transforming-growth-factor-%C3%AE-1-gene-polymorphism-in-psoriasis-vulgaris
#14
Heba H El-Hadidi, Akmal S Hassan, Ghada El-Hanafy, Khalda S Amr, Sameh F Abdelmesih, Mahmoud F Abdelhamid
Background: Increased transforming growth factor beta 1 (TGF-β1) in the epidermis and serum has been found in psoriatic patients. The mechanism for this increase remains unclear. Objective: To study the TGF-β1 gene polymorphism at codon 10 and its relation to psoriasis susceptibility in a sample of Egyptian patients. Materials and methods: This cross-sectional study involved 70 patients with psoriasis vulgaris and 100 age- and sex- comparable healthy volunteers as a control group...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30122971/current-treatment-options-for-acanthosis-nigricans
#15
REVIEW
Nupur U Patel, Catherine Roach, Hossein Alinia, William W Huang, Steven R Feldman
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. While the goal of therapy is to treat the primary cause, cosmetic resolution of AN lesions can be important for patients and their quality of life...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30122970/acne-fulminans-associated-with-lymecycline-intake-a-case-report
#16
Bruno Gualtieri, Annalisa Tonini, Salvatore Panduri, Andrea Chiricozzi, Marco Romanelli
Acne fulminans (AF) is a rare acne variant characterized by sudden onset of painful nodules on the face, chest, and back in the presence of systemic symptoms. Pharmacologic agents such as steroid hormones and isotretinoin are well-known triggers, and several cases have been described. We report a case of AF occurring a few days after lymecycline therapy initiation.
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30122969/werner-syndrome-quantitative-assessment-of-skin-aging
#17
Vittorio Mazzarello, Marco Ferrari, Pasquale Ena
Background: Werner syndrome (WS) is a rare autosomal recessive disorder characterized by premature aging in adults. Although not sufficient to diagnose WS, persistent short stature and alteration of the dentition are among the few early signs that appear at puberty and can lead to a suspected diagnosis. Objective: The study aimed at quantifying the signs of WS skin aging through biophysical parameters to find new parameters to be applied together with clinical observations in order to diagnose the disease early...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30087573/triamcinolone-acetonide-intralesional-injection-for-the-treatment-of-keloid-scars-patient-selection-and-perspectives
#18
REVIEW
Marco Morelli Coppola, Rosa Salzillo, Francesco Segreto, Paolo Persichetti
Keloids are pathological scars presenting as nodular lesions that extend beyond the area of injury. They do not spontaneously regress, often continuing to grow over time. The abnormal wound-healing process underlying keloid formation results from the lack of control mechanisms self-regulating cell proliferation and tissue repair. Keloids may lead to cosmetic disfigurement and functional impairment and affect the quality of life. Although several treatments were reported in the literature, no universally effective therapy was found to date...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30046249/vitiligo-and-social-acceptance
#19
Reza Bidaki, Niloofar Majidi, Amir Moghadam Ahmadi, Hamid Bakhshi, Rezvan Sadr Mohammadi, Seyed-Ali Mostafavi, Mohammad Kazemi Arababadi, Maryam Hadavi, Afshin Mirzaei
Background and aim: Vitiligo is a chronic skin disease characterized by a total or partial loss of melanocytes from the epidermis and other tissues of the skin. It is placed in the class of secondary psychiatric disorders and can also lead to psychological problems. The main aim of this study was to assess social acceptance in vitiligo patients. Methods: This cross-sectional study was conducted on all of the patients (n=150) with vitiligo who were referred to dermatology clinics in Rafsanjan, Iran...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/30038513/a-novel-dermo-cosmetic-product-containing-thermal-spring-water-sucralfate-copper-sulfate-and-zinc-sulfate-in-the-management-of-hand-eczema
#20
Virginie Ribet, Ewa Mielewczyk, Anne Sirvent, Victor Georgescu, Ana Beatris Rossi
Background: The regular use of cosmetic products plays a role in the management of hand eczema (HE) and aids in improving barrier function reducing dryness, roughness, pruritus and improving quality of life (QoL). The aim of this open-label study was to assess the efficacy and the reparative effect of a dermo-cosmetic product on subjects suffering from HE after 7 and 21 days of daily application. Methods: The product was a water-in-oil (W/O) emulsion containing the active ingredients Avène thermal spring water, sucralfate, and copper and zinc sulfates...
2018: Clinical, Cosmetic and Investigational Dermatology
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