journal
MENU ▼
Read by QxMD icon Read
search

Clinical, Cosmetic and Investigational Dermatology

journal
https://www.readbyqxmd.com/read/28932126/dermopathy-associated-with-cetuximab-and-panitumumab-investigation-of-the-usefulness-of-moisturizers-in-its-management
#1
Shoichi Watanabe, Motoki Nakamura, Hiroki Takahashi, Masayasu Hara, Kei Ijichi, Daisuke Kawakita, Akimichi Morita
AIMS: Limited data regarding the objective evaluation of skin exsiccation caused by epidermal growth factor receptor (EGFR) inhibitors exist. Objective indices were applied to evaluate the usefulness of a moisturizer against skin exsiccation associated with the use of EGFR inhibitors in cancer patients. PATIENTS AND METHODS: Patients with either colorectal or head and neck cancer treated with either cetuximab or panitumumab were randomly assigned 1:2 to the prophylactic-treatment arm, where participants received prophylactical moisturizer treatment (heparinoid preparation, Hirudoid(®)), or to the symptomatic-treatment arm, where moisturizer was applied after the onset of cutaneous symptoms...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28932125/an-empirically-generated-responder-definition-for-rosacea-treatment
#2
Gerald Staedtler, Kaweh Shakery, Jan Endrikat, Richard Nkulikiyinka, Christoph Gerlinger
OBJECTIVE: The aim of this study was to empirically generate a responder definition for the treatment of papulopustular rosacea. METHODS: A total of 8 multicenter clinical studies on patients with papulopustular facial rosacea were analyzed. All patients were treated with azelaic acid and/or comparator treatments. The severity of rosacea was described by the Investigator Global Assessment (IGA) and the number of lesions. Patients with the IGA score of "clear/minimal" were considered as responders, and those staying in the range of IGA "mild to severe" as nonresponders...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28919796/psoriasis-and-vitiligo-are-close-relatives
#3
Khalifa E Sharquie, Husam Ali Salman, Aseel K Yaseen
BACKGROUND: Both vitiligo and psoriasis are chronic inflammatory autoimmune diseases with genetic elements. OBJECTIVE: To estimate the frequencies of psoriasis in vitiligo patients and vice versa and to compare them with healthy controls. PATIENTS AND METHODS: A total of 1000 subjects were included, 250 of them had vitiligo, 250 had psoriasis, and 500 were healthy controls. Measurement of the frequencies of vitiligo in psoriatic patients and psoriasis in vitiligo patients was carried out...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28883738/checkpoint-inhibitors-for-malignant-melanoma-a-systematic-review-and-meta-analysis
#4
REVIEW
Adam K Karlsson, Sohag N Saleh
BACKGROUND AND OBJECTIVES: Rates of malignant melanoma are continuing to increase, and until recently effective treatments were lacking. However, since 2011 three immunotherapeutic agents, known as checkpoint inhibitors, have been approved. This review aims to establish whether these three drugs - ipilimumab, nivolumab, and pembrolizumab - offer greater efficacy and tolerability compared to control interventions (placebo, immunotherapy, or chemotherapy) in patients with stage III or IV unresectable cutaneous melanoma...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28883737/scabies-masquerading-as-bullous-pemphigoid-scabies-surrepticius
#5
Philip R Cohen
Scabies, a parasitic infestation caused by the mite Sarcoptes scabiei, is diagnosed by observing either the mite, its ova, or its excrement. The mite tracts, known as burrows and a characteristic presentation of the pruritic condition, are typically found on the web spaces between the fingers. Other cutaneous lesions include excoriated papules, pustules, and vesicles. However, atypical clinical variants of scabies, such as bullous, crusted, hidden, incognito, nodular, and scalp forms of the parasitic infestation, mimic the morphologic features of other non-parasitic dermatoses...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28860834/the-24-hour-skin-hydration-and-barrier-function-effects-of-a-hyaluronic-1-glycerin-5-and-centella-asiatica-stem-cells-extract-moisturizing-fluid-an-intra-subject-randomized-assessor-blinded-study
#6
Massimo Milani, Adele Sparavigna
INTRODUCTION: Moisturizing products are commonly used to improve hydration in skin dryness conditions. However, some topical hydrating products could have negative effects on skin barrier function. In addition, hydrating effects of moisturizers are not commonly evaluated up to 24 hours after a single application. Hyaluronic acid (HA) and glycerin are very well-known substances able to improve skin hydration. Centella asiatica extract (CAE) could exert lenitive, anti-inflammatory and reepithelialization actions...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28848358/rosacea-and-helicobacter-pylori-links-and-risks
#7
REVIEW
Elizabeth Lazaridou, Chrysovalantis Korfitis, Christina Kemanetzi, Elena Sotiriou, Zoe Apalla, Efstratios Vakirlis, Christina Fotiadou, Aimilios Lallas, Demetrios Ioannides
Rosacea is a chronic skin disease characterized by facial erythema and telangiectasia. Despite the fact that many hypotheses have been proposed, its etiology remains unknown. In the present review, the possible link and clinical significance of Helicobacter pylori in the pathogenesis of rosacea are being sought. A PubMed and Google Scholar search was performed using the terms "rosacea", "H.pylori", "gastrointestinal disorders and H.pylori", "microorganisms and rosacea", "pathogenesis and treatment of rosacea", and "risk factors of rosacea", and selected publications were studied and referenced in text...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28848357/emu-oil-based-lotion-effects-on-neonatal-skin-barrier-during-transition-from-intrauterine-to-extrauterine-life
#8
Vincenzo Zanardo, David Giarrizzo, Francesca Volpe, Lara Giliberti, Gianluca Straface
Both appropriate hydration and skin surface pH are fundamental in preventing baby skin barrier damage during transition from intrauterine to extrauterine life. However, effects of topical moisturizers on neonatal stratum corneum temperature, pH, hydration, and elasticity have not been scientifically evaluated in vivo. We checked 31 full-term breastfeeding neonates by non-invasive bioengineering method, which is able to evaluate the basal skin barrier (left heel), and assessed at 6±1 hours after birth, and at 1 and 24 hours after emu oil-based topical treatment...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28848356/review-of-applications-of-microneedling-in-dermatology
#9
REVIEW
Christopher Iriarte, Olabola Awosika, Monica Rengifo-Pardo, Alison Ehrlich
Microneedling (MN) is a novel therapeutic modality in dermatology. Through physical trauma from needle penetration, MN induces a wound healing cascade with minimal damage to the epidermis. This allows for enhancement in the absorption of mainstay topical therapies across the thick stratum corneum. MN has become increasingly utilized over the last several years as it is a relatively simple procedure that is cost-effective, well tolerated, and offers both cosmetic and therapeutic benefits. The ability to treat localized areas of disease has led to numerous studies gauging its potential in focal diseases of inflammation, dyschromia, and photodamage...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28814892/treatment-of-a-traumatic-atrophic-depressed-scar-with-hyaluronic-acid-fillers-a-case-report
#10
Syed Nazim Hussain, Greg J Goodman, Eqram Rahman
BACKGROUND: Hyaluronic acid filler has been documented in the treatment of atrophic depressed acne scars relatively frequently in the literature but rarely in chronic depressed traumatic atrophic facial scars. METHODS: This case report discusses the use of hyaluronic acid fillers in the correction of a post-traumatic facial atrophic scar on the right cheek. RESULTS: The right cheek scar was substantially corrected with one session of two different hyaluronic acids injected in a deep and superficial plane...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28794649/an-open-label-forearm-controlled-pilot-study-to-assess-the-effect-of-a-proprietary-emollient-formulation-on-objective-parameters-of-skin-function-of-eczema-prone-individuals-over-14-days
#11
Michael Paul Wakeman
BACKGROUND: This study examines the efficacy of a new plant-based emollient and assesses product acceptability. METHODS: Primary efficacy endpoints were improvement in transepidermal water loss, hydration, skin elasticity and firmness, erythema, and skin roughness and smoothness as measured using the versions of Tewameter, Corneometer, Cutometer, Mexameter, and Visioscan VC98, respectively. The cream was applied twice daily by 32 participants to an area of one forearm unaffected by eczema, while the same area of the other forearm was used as a control...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28761365/oral-hyaluronan-relieves-wrinkles-a-double-blinded-placebo-controlled-study-over-a-12-week-period
#12
Mariko Oe, Seigo Sakai, Hideto Yoshida, Nao Okado, Haruna Kaneda, Yasunobu Masuda, Osamu Urushibata
BACKGROUND: Hyaluronan (HA) has critical moisturizing property and high water retention capacity especially for human skin. This study aimed to evaluate the effect of oral intake of HA. METHODS: The mean molecular weight (MW) of HA is 2 k and 300 k. Sixty Japanese male and female subjects aged 22-59 years who presented with crow's feet wrinkles were randomly assigned to the HA 2 k or HA 300 k at 120 mg/day or the placebo group. The subjects were administered HA at a rate of 120 mg/day or a placebo for 12 weeks...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28761364/effect-of-astaxanthin-on-cutaneous-wound-healing
#13
Jitlada Meephansan, Atiya Rungjang, Werayut Yingmema, Raksawan Deenonpoe, Saranyoo Ponnikorn
Wound healing consists of a complex series of convoluted processes which involve renewal of the skin after injury. ROS are involved in all phases of wound healing. A balance between oxidative and antioxidative forces is necessary for a favorable healing outcome. Astaxanthin, a member of the xanthophyll group, is considered a powerful antioxidant. In this study, we investigated the effect of topical astaxanthin on cutaneous wound healing. Full-thickness dermal wounds were created in 36 healthy female mice, which were divided into a control group and a group receiving 78...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28721083/effect-of-a-lotion-containing-the-heat-treated-probiotic-strain-lactobacillus-johnsonii-ncc-533-on-staphylococcus-aureus-colonization-in-atopic-dermatitis
#14
Sandrine Blanchet-Réthoré, Valérie Bourdès, Annick Mercenier, Cyrille H Haddar, Paul O Verhoeven, Philippe Andres
OBJECTIVE: Staphylococcus aureus dominates the skin microbiota in patients with atopic dermatitis (AD), with bacterial loads correlating with disease severity. The aim of this exploratory study was to investigate the effect of a cosmetic lotion containing heat-treated Lactobacillus johnsonii NCC 533 (HT La1) on S. aureus colonization in AD patients. METHODS: This open-label, multicenter study was performed in AD patients in Germany. First, detection of S. aureus was performed in all patients using the swab or scrub-wash method of sampling, followed by quantitative culture or quantitative polymerase chain reaction...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28721082/effectiveness-evaluation-of-two-volumizing-hyaluronic-acid-dermal-fillers-in-a-controlled-randomized-double-blind-split-face-clinical-study
#15
Martina Kerscher, Karla Agsten, Maria Kravtsov, Welf Prager
BACKGROUND: Enhancement of the midface can be achieved with volumizing hyaluronic acid (HA) fillers. OBJECTIVE: The objective of this study was to compare the safety and effectiveness of Cohesive Polydensified Matrix(®) 26 mg/mL HA gel (CPM-26) and Vycross(®) 20 mg/ml HA gel (VYC-20) in a controlled, randomized, evaluator-blind, split-face clinical study. PATIENTS AND METHODS: Subjects with moderate-to-severe malar volume loss on the Merz Aesthetics Scale (MAS) received CPM-26 on one side and VYC-20 on the contralateral side of the face...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28652795/minimal-recovery-time-needed-to-return-to-social-engagement-following-nasolabial-fold-correction-with-hyaluronic-acid-fillers-produced-with-xpreshan-technology
#16
Arthur Swift, Erika von Grote, Brandie Jonas, Alessandra Nogueira
INTRODUCTION: The appeal of hyaluronic acid fillers for facial soft tissue augmentation is attributable to both an immediate aesthetic effect and relatively short recovery time. Although recovery time is an important posttreatment variable, as it impacts comfort with appearance and perceived treatment benefit, it is not routinely evaluated. Natural-looking aesthetic outcomes are also a primary concern for many patients. MATERIALS AND METHODS: A single-center, noncomparative study evaluated the time (in hours) until subjects return to social engagement (RtSE) following correction of moderate and severe nasolabial folds (NLFs) with RR (Restylane(®) Refyne)(®) and RD (Restylane Defyne), respectively...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28652794/epidemiology-of-fragile-skin-internet-based-surveys-in-mexico-and-russia
#17
Jorge Ocampo-Candiani, Nikolay Murashkin, Asmaa Zkik, Markéta Saint Aroman, Pierre Wolkenstein
BACKGROUND: Fragile skin is a poorly understood skin condition, particularly in the general adult population. There are currently limited epidemiological data on the prevalence of fragile skin in adults. The objectives of this study were to assess the prevalence of perceived fragile skin across different skin types in representative samples of the general adult populations in Mexico and Russia, and to identify skin characteristics associated with perceived fragile skin. METHODS: Two identical cross-sectional surveys, using a short online self-administered questionnaire, were conducted on samples of recruited individuals that were representative of the general Mexican and Russian populations...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28652793/evaluation-of-a-novel-very-high-sun-protection-factor-moisturizer-in-adults-with-rosacea-prone-sensitive-skin
#18
Mathieu Grivet-Seyve, Francine Santoro, Nadège Lachmann
BACKGROUND/OBJECTIVE: Rosacea-prone sensitive skin requires high sun-protection factor (SPF) moisturizers. This study evaluated Daylong Extreme SPF 50+ lotion, a novel cream containing five ultraviolet filters, two emollients, and three skin conditioners. SUBJECTS AND METHODS: This was an open-label, single-center study. On day 1, before treatment, subjects answered a questionnaire on their skin conditions and sunscreen habits, and both subjects and dermatologist evaluated skin status...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28652792/severe-atypical-herpes-zoster-as-an-initial-symptom-of-fatal-myelodysplastic-syndrome-with-refractory-anemia-and-blast-excess-raeb-ii
#19
Uwe Wollina, Gesina Hansel, Anja Baunacke, Georgi Tchernev
Herpes zoster is a common disease caused due to varicella zoster virus (VZV) infection with increasing incidence by age. If the patient has a severe, extended, or treatment-recalcitrant course of herpes zoster, this must be a red flag to search for underlying pathologies. Here, we report about a 64-year-old male patient with diabetes, who came to our emergency department because of general malaise, fever, chills, and a pronounced nuchal and facial swelling on the left side. Based on herpetiform-grouped vesicles and yellowish crusts, an impetiginized facial herpes zoster was diagnosed, and combined antiviral and antibiotic treatment was initiated...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28579816/tattoo-removal-with-ingenol-mebutate
#20
Sarah-Jane Cozzi, Thuy T Le, Steven M Ogbourne, Cini James, Andreas Suhrbier
An increasing number of people are getting tattoos; however, many regret the decision and seek their removal. Lasers are currently the most commonly used method for tattoo removal; however, treatment can be lengthy, costly, and sometimes ineffective, especially for certain colors. Ingenol mebutate is a licensed topical treatment for actinic keratoses. Here, we demonstrate that two applications of 0.1% ingenol mebutate can efficiently and consistently remove 2-week-old tattoos from SKH/hr hairless mice. Treatment was associated with relocation of tattoo microspheres from the dermis into the posttreatment eschar...
2017: Clinical, Cosmetic and Investigational Dermatology
journal
journal
43292
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"