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Clinical, Cosmetic and Investigational Dermatology

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https://www.readbyqxmd.com/read/29950878/current-perspectives-on-mohs-micrographic-surgery-for-melanoma
#1
REVIEW
Derek Beaulieu, Ramin Fathi, Divya Srivastava, Rajiv I Nijhawan
Mohs micrographic surgery (MMS), a specialized surgical excision technique used primarily in the treatment of skin cancers, is tissue sparing and provides optimal margin control through evaluation of 100% of both the peripheral and deep margin. The use of MMS for the treatment of malignant melanoma (MM) and melanoma in situ (MIS) has been slow in gaining the same widespread acceptance that it has for keratinocyte carcinomas despite its cost-effectiveness and the growing body of evidence demonstrating similar or improved cure rates to standard wide local excision...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29928140/involvement-of-the-nuclear-structural-proteins-in-aging-related-responses-of-human-skin-to-the-environmental-stress
#2
REVIEW
Ewa Markiewicz, Olusola Clement Idowu
Human skin is a stratified endocrine organ with primary roles in protection against detrimental biochemical and biophysical factors in the environment. Environmental stress causes gradual accumulation of the macromolecular damage and clinical manifestations consistent with chronic inflammatory conditions and premature aging of the skin. Structural proteins of cell nucleus, the nuclear lamins and lamina-associated proteins, play an important role in the regulation of a number of signal transduction pathways associated with stress...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29928139/impact-of-multiple-extragenital-warts-on-quality-of-life-in-immune-competent-egyptian-adults-a-comparative-cross-sectional-study
#3
Eman Salah
Background: Extragenital warts (E-GWs) are common benign skin lesions caused by human papilloma virus. Surprisingly, there is no clear data about the impact of multiple E-GWs on quality of life in immune-competent adult patients in comparison to GWs, which have been frequently reported to exhibit a strong negative impact on life quality. Patients and methods: This cross-sectional study investigated the impact of multiple E-GWs on quality of life in immune-competent adults as they are more commonly encountered in daily practice than their genital counterpart in the Egyptian population...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29910630/botulinum-neurotoxin-formulations-overcoming-the-confusion
#4
REVIEW
Souphiyeh Samizadeh, Koenraad De Boulle
Botulinum toxin A is produced by anaerobic spore-forming bacteria and is used for various therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular nonsurgical procedure worldwide. Despite an increased demand for botulinum toxin A injections, the clinical pharmacology and differences in formulation of commonly available products are poorly understood. The various products available in the market are unique and vary in terms of units, chemical properties, biological activities, and weight, and are therefore not interchangeable...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29910629/investigating-the-therapeutic-potential-of-a-probiotic-in-a-clinical-population-with-chronic-hand-dermatitis
#5
Wayne P Gulliver, Andrew S Hutton, Noam Ship
Background: Hand dermatitis or hand eczema (HD) is one of the most common dermatologic conditions. Lesions, scaling, pruritus and pain are chronic and relapsing. Improved HD has been reported with the probiotic composed of Lactobacillus acidophilus CL1285, Lactobacillus casei LBC80R and Lactobacillus rhamnosus CLR2 (Bio-K+). Purpose: Investigation of the therapeutic potential of this probiotic as the sole systemic treatment for adults with nonacute HD. Subjects and methods: A single-center study documented clinical ratings and patient-reported outcomes in adults with chronic HD...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29881301/antiaging-effects-of-a-novel-facial-serum-containing-l-ascorbic-acid-proteoglycans-and-proteoglycan-stimulating-tripeptide-ex-vivo-skin-explant-studies-and-in-vivo-clinical-studies-in-women
#6
Aurora Garre, Mridvika Narda, Palmira Valderas-Martinez, Jaime Piquero, Corinne Granger
Background: With age, decreasing dermal levels of proteoglycans, collagen, and elastin lead to the appearance of aged skin. Oxidation, largely driven by environmental factors, plays a central role. Aim: The aim of this study was to assess the antiaging efficacy of a topical serum containing L-Ascorbic acid, soluble proteoglycans, low molecular weight hyaluronic acid, and a tripeptide in ex vivo and in vivo clinical studies. Methods: Photoaging and photo-oxidative damage were induced in human skin explants by artificial solar radiation...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29785134/the-impact-of-acne-and-facial-post-inflammatory-hyperpigmentation-on-quality-of-life-and-self-esteem-of-newly-admitted-nigerian-undergraduates
#7
Adeolu Oladayo Akinboro, Ogochukwu Ifeanyi Ezejiofor, Fatai Olatunde Olanrewaju, Mufutau Muphy Oripelaye, Olatunde Peter Olabode, Olugbenga Edward Ayodele, Emmanuel Olaniyi Onayemi
Background: Acne and facial post-inflammatory hyperpigmentation are relatively common clinical conditions among adolescents and young adults, and inflict psychosocial injuries on sufferers. Objective: To document the psychosocial and self-esteem implications of acne and facial hyperpigmentation on newly admitted undergraduates. Materials and methods: A cross-sectional survey was conducted among 200 undergraduates. Demographics and clinical characteristics were obtained and acne was graded using the US Food and Drug Administration 5-category global system of acne classification...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29785133/are-quantitative-histopathologic-criteria-capable-of-differentiating-psoriasis-from-chronic-dermatitis
#8
Hamid Reza Ghasemi Basir, Pedram Alirezaei, Zahra Hamian, Elham Khanlarzadeh
Background: There are overlapping features in histopathologic characteristics of psoriasis and chronic dermatitis, which sometimes make the correct diagnosis difficult. Objective: The aim of this study was to compare the histopathologic diagnostic features of psoriasis with chronic dermatitis quantitatively. Patients and methods: In this study, 30 patients with psoriasis and 30 patients with chronic dermatitis were included. Diagnosis of psoriasis or chronic dermatitis was based on clinicopathologic correlation...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29750049/current-trends-in-needle-free-jet-injection-an-update
#9
REVIEW
Daniel Barolet, Antranik Benohanian
Background: Jet injection can be defined as a needle-free drug delivery method in which a high-speed stream of fluid impacts the skin and delivers a drug. Despite 75 years of existence, it never reached its full potential as a strategic tool to deliver medications through the skin. Objective: The aim of this review was to evaluate and summarize the evolution of jet injection intradermal drug delivery method including technological advancements and new indications for use...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29750048/genitogluteal-porokeratosis-a-clinical-review
#10
REVIEW
Rajiv Joshi, Khushboo Minni
Porokeratosis is an uncommon disorder of keratinization that presents with keratotic papules or annular plaques that expand centrifugally with a thread-like elevated border. A distinctive histologic structure, the cornoid lamella, is diagnostic of this disorder and consists of a column of parakeratosis with the absence of the granular layer and dyskeratotic cells in the upper spinous zone. Porokeratosis confined to the genitogluteal region is rare and may be subclassified into three types, namely, classical porokeratosis on the genital region, ptychotropic porokeratosis most often seen in the natal cleft and buttocks and penoscrotal porokeratosis that is seen on the penis and adjacent scrotal skin in young men in their third decade of life...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29750047/skin-acceptability-of-a-cosmetic-moisturizer-formulation-in-female-subjects-with-sensitive-skin
#11
Stephanie J Nisbet
Purpose: This 3-week, open-label, noncomparative clinical study evaluated the skin acceptability of a cosmetic moisturizer in subjects with sensitive skin, by monitoring adverse events (AEs) and cutaneous discomfort related to normal usage. Materials and methods: Female subjects aged between 18-60 years, with Fitzpatrick phototype classification I-IV and sensitive skin, verified by a positive reaction on the stinging test at screening, were included. Subjects applied the moisturizer to their face and body twice daily for 21±2 days at home and recorded study product usage and feelings of cutaneous discomfort (eg, dryness, prickling, stinging, and itching) in a diary; any AEs were reported to the clinic...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29750046/improvement-of-dermal-parameters-in-aged-skin-after-oral-use-of-a-nutrient-supplement
#12
Flávia Alvim Sant'Anna Addor, Juliana Cotta Vieira, Camila Sirieiro Abreu Melo
Purpose: Skin aging is a progressive and degenerative process caused by a decrease in the physiological functions of the skin tissue. In addition, environmental factors as well as concomitant diseases and lifestyle (nutrition, sedentary lifestyle, smoking, etc) negatively impact the aging process. An association between oral administration of collagen peptides combined with vitamin C and extracts of Hibiscus sabdariffa and Aristotelia chilensis (Delphynol® ) (Eximia Firmalize Age complex® ) on dermal thickness was studied and the improvement in aging signs was evaluated...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29731654/synergistic-effects-of-combined-therapy-nonfocused-ultrasound-plus-aussie-current-for-noninvasive-body-contouring
#13
Vivianne Carvalho Canela, Cinthia Nicoletti Crivelaro, Luciane Zacchi Ferla, Gisele Marques Pelozo, Juliana Azevedo, Richard Eloin Liebano, Caroline Nogueira, Renata Michelini Guidi, Clóvis Grecco, Estela Sant'Ana
Background and objectives: Nowadays, there are several noninvasive technologies being used for improving of body contouring. The objectives of this pilot study were to verify the effectiveness of the Heccus® device, emphasizing the synergism between nonfocused ultrasound plus Aussie current in the improvement of body contour, and to determine if the association of this therapy with whole-body vibration exercises can have additional positive effects in the results of the treatments. Subjects and methods: Twenty healthy women aged 20-40 years participated in the study...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29731653/histologic-characterization-of-cellular-infiltration-in-autoimmune-subepidermal-bullous-diseases-in-a-tertiary-hospital-in-saudi-arabia
#14
Hessah F BinJadeed, Alanoud M Alyousef, Fahad M Alsaif, Ahmed A Alhumidi, Homaid O Alotaibi
Background: Autoimmune subepidermal bullous dermatoses have similar clinical features to those of a spectrum of immune reactants at the dermoepidermal junction (DEJ). It is difficult to obtain a precise diagnosis without an immunofluorescence assay because of their similar clinical presentations. The aim of this study was to describe the cellular cutaneous infiltration among autoimmune subepidermal bullous dermatoses. Materials and methods: This retrospective analysis was conducted at a hospital in Riyadh, Saudi Arabia using biopsy-based data collected from 65 patients...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29713190/recurrent-candidal-intertrigo-challenges-and-solutions
#15
REVIEW
Ahmet Metin, Nursel Dilek, Serap Gunes Bilgili
Intertrigo is a common inflammatory dermatosis of opposing skin surfaces that can be caused by a variety of infectious agents, most notably candida, under the effect of mechanical and environmental factors. Symptoms such as pain and itching significantly decrease quality of life, leading to high morbidity. A multitude of predisposing factors, particularly obesity, diabetes mellitus, and immunosuppressive conditions facilitate both the occurrence and recurrence of the disease. The diagnosis of candidal intertrigo is usually based on clinical appearance...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29697695/exploring-the-relationship-between-stress-and-acne-a-medical-student-s-perspective
#16
COMMENT
Aryan Maleki, Noorulain Khalid
No abstract text is available yet for this article.
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29692619/personalized-skincare-from-molecular-basis-to-clinical-and-commercial-applications
#17
REVIEW
Ewa Markiewicz, Olusola Clement Idowu
Individual responses of human skin to the environmental stress are determined by differences in the anatomy and physiology that are closely linked to the genetic characteristics such as pigmentation. Ethnic skin phenotypes can be distinguished based on defined genotypic traits, structural organization and compartmentalized sensitivity to distinct extrinsic aging factors. These differences are not only responsible for the variation in skin performance after exposure to damaging conditions, but can also affect the mechanisms of drug absorption, sensitization and other longer term effects...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29670386/traction-alopecia-the-root-of-the-problem
#18
REVIEW
Victoria Billero, Mariya Miteva
Traction alopecia (TA) affects one-third of women of African descent who wear various forms of traumatic hairstyling for a prolonged period of time. The risk of TA is increased by the extent of pulling and duration of traction, as well as the use of chemical relaxation. The frequent use of tight buns or ponytails, the attachment of weaves or hair extensions, and tight braids (such as cornrows and dreadlocks) are believed to be the highest risk hairstyles. TA can also occur in the setting of religious and occupational traumatic hairstyling...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29670385/the-efficacy-of-a-pseudo-ceramide-and-eucalyptus-extract-containing-lotion-on-dry-scalp-skin
#19
Yutaka Takagi, Xuanhe Ning, Akihiko Takahashi, Chiaki Ishizaki, Takahiro Nishizaka, Kazuhiro Kaizu, Masahiro Miyaki, Hotaka Yamamuro, Makoto Kawashima
Objective: Dry and scaly conditions on the scalp are often observed in patients with atopic dermatitis, seborrheic dermatitis and/or pityriasis capitis. Those scalp lesions often exhibit low barrier function and reduced ceramide levels. Therefore, a clinical study was conducted to evaluate the efficacy of topical application of a pseudo-ceramide and eucalyptus extract-containing lotion on the scalps of patients with skin diseases. Methods: Thirty-four subjects participated in this study (atopic dermatitis: 19 subjects; seborrheic dermatitis: 6 subjects; pityriasis capitis: 9 subjects)...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29662322/a-comparative-trial-of-ice-application-versus-emla-cream-in-alleviation-of-pain-during-botulinum-toxin-injections-for-palmar-hyperhidrosis
#20
Adel Alsantali
Background: Botulinum toxin is a safe and effective therapy for palmar hyperhidrosis, but the associated pain from injections limits the usefulness of this method of treatment. Purpose: To evaluate the efficacy of Eutectic Mixture of Local Anesthetics (EMLA) cream versus ice application in alleviation of pain during botulinum toxin injections for palmar hyperhidrosis. Methods: In this prospective study, 23 patients underwent palm Botox injections to treat their excessive sweating...
2018: Clinical, Cosmetic and Investigational Dermatology
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