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Clinical, Cosmetic and Investigational Dermatology

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https://www.readbyqxmd.com/read/29296091/xanthelasma-palpebrarum-a-brief-review
#1
REVIEW
Pragya A Nair, Rochit Singhal
Xanthelasma palpebrarum is the most common cutaneous xanthoma, characterized by yellowish plaques over eyelids - most commonly, over the inner canthus of the upper lid. It is triggered by hyperlipidemia, thyroid dysfunction, and diabetes mellitus. Xanthelasma results from perivascular infiltration of mono- and multinucleated foam cells within lipid-laden cytoplasmic vacuoles in the superficial reticular dermis. Different modalities of treatment, such as simple surgical excision, cryotherapy, chemical peeling with trichloroacetic acid, radiofrequency, and laser, are used in the treatment of xanthelasma palpebrarum...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29276401/cohesive-polydensified-matrix%C3%A2-hyaluronic-acid-volumizer-injected-for-cheek-augmentation-has-additional-positive-effect-on-nasolabial-folds
#2
Gerd Gauglitz, Stephanie Steckmeier, Julian Pötschke, Hannah Schwaiger
Purpose: Cohesive Polydensified Matrix® hyaluronic acid (CPM-HA) volumizer has been used successfully for several years to reverse biometric volume loss during facial aging. This observational study explored the additive effect on nasolabial folds when CPM-HA volumizer is injected into the neighboring cheek area. Patients and methods: In this open-label, prospective, postmarketing noninterventional study, 18 adult patients seeking esthetic enhancement of the lateral cheek hollows and cheekbone area were injected with CPM-HA volumizer integrated with lidocaine (CPM-HA-VL) in the upper or lower cheek area...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29270028/identification-of-dihydrogambogic-acid-as-a-matrix-metalloproteinase-1-inhibitor-by-high-throughput-screening
#3
Yong Li, John J Voorhees, Gary J Fisher
No abstract text is available yet for this article.
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29255370/the-association-between-stress-and-acne-among-female-medical-students-in-jeddah-saudi-arabia
#4
Shadi Zari, Dana Alrahmani
Introduction: Although there is widespread acceptance of a relationship between stress and acne, not many studies have been performed to assess this relationship. The objective of this study was to determine the relationship between stress and acne severity. Methods: A cross-sectional study was conducted among 144 6th year female medical students 22 to 24 years in age attending the medical faculty at King Abdulaziz University. This study used the global acne grading system (GAGS) to assess acne severity in relation to stress using the Perceived Stress Scale (PSS)...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29200884/associations-between-body-mass-index-and-severity-of-psoriasis
#5
Mohammadreza Sobhan, Mahmoud Farshchian
Objective: Compared with healthy people, overweight and obesity are more commonly found among those suffering from skin conditions such as psoriasis. The present study was an attempt to survey the relationship between obesity and intensity of psoriasis. Patients and methods: A total of 42 patients with psoriasis who were referred to Farshchian Hospital, Hamadan, participated in this cross-sectional descriptive-analytical study. Patients were classified into mild, moderate and severe based on the intensity of the disease measured by Psoriasis Area and Severity Index (PASI)...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29184429/topical-application-of-st266-reduces-uv-induced-skin-damage
#6
Linna Guan, Amanda Suggs, Emily Galan, Minh Lam, Elma D Baron
Ultraviolet radiation (UVR) has a significant impact on human skin and is the major environmental factor for skin cancer formation. It is also believed that 80% of the signs of skin aging are attributed to UVR. UVR induces inflammatory changes in the skin via the increase in oxidative stress, DNA damage vascular permeability, and fluctuation in a myriad of cytokines. Acutely, UVR causes skin inflammation and DNA damage, which manifest as sunburn (erythema). ST266 is the secretome of proprietary amnion-derived cells that have been shown to reduce inflammation and accelerate healing of various wounds by promoting migration of keratinocytes and fibroblasts in preclinical animal studies...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29184428/management-of-refractory-pityriasis-rubra-pilaris-challenges-and-solutions
#7
REVIEW
Gaia Moretta, Erika V De Luca, Alessandro Di Stefani
Pityriasis rubra pilaris (PRP) is a rare chronic inflammatory papulosquamous skin disease. Its clinical presentation and evolution is very variable. The most frequent clinical features are follicular papules, progressing to yellow-orange erythroderma with round small areas of normal skin and the well-demarcated palmoplantar keratoderma. Actually, six different types of PRP have been described based on clinical characteristics, age of onset, and prognosis. The pathogenesis is still unknown, and treatment can be challenging...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29184427/pemphigoid-gestationis-current-perspectives
#8
REVIEW
Christine Sävervall, Freja Lærke Sand, Simon Francis Thomsen
Many skin diseases can occur in pregnant women. However, a few pruritic dermatological conditions are unique to pregnancy, including pemphigoid gestationis (PG). As PG is associated with severe morbidity for pregnant women and carries fetal risks, it is important for the clinician to quickly recognize this disease and refer it for dermatological evaluation and treatment. Herein, we review the pathogenesis, clinical characteristics, and management of PG.
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29184426/recommendations-for-volume-augmentation-and-rejuvenation-of-the-face-and-hands-with-the-new-generation-polycaprolactone-based-collagen-stimulator-ellans%C3%A3-%C3%A2
#9
REVIEW
Francisco de Melo, Pierre Nicolau, Luca Piovano, Shang-Li Lin, Tiago Baptista-Fernandes, Martyn I King, Alessandra Camporese, Kyungkook Hong, Maria M Khattar, Marie-Odile Christen
Background: The range of fillers currently available for soft-tissue augmentation is constantly expanding. The latest advances in filler technology include collagen biostimulators that exert their esthetic effect by promoting neocollagenesis. One such product is the next-generation collagen biostimulator (Ellansé®) that demonstrates properties as yet unseen in soft-tissue fillers. It is composed of polycaprolactone (PCL) microspheres in an aqueous carboxymethylcellulose gel carrier...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29180885/long-term-effect-of-the-insoluble-thread-lifting-technique
#10
Mototsugu Fukaya
Background: Although the thread-lifting technique for sagging faces has become more common and popular, medical literature evaluating its effects is scarce. Studies on its long-term prognosis are particularly uncommon. Patients and methods: One hundred individuals who had previously undergone insoluble thread-lifting were retrospectively investigated. Photos in frontal and oblique views from the first and last visits were evaluated by six female individuals by guessing the patients' ages...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29180884/redefining-face-contour-with-a-novel-anti-aging-cosmetic-product-an-open-label-prospective-clinical-study
#11
Aurora Garre, Gemma Martinez-Masana, Jaime Piquero-Casals, Corinne Granger
Background: Skin aging is accelerated by multiple extrinsic factors: ultraviolet radiation, smoking and pollution increase oxidative activity, damaging cellular and extracellular components such as DNA, proteins, and lipids. With age, collagen and hyaluronic acid levels decline, resulting in loss of elasticity and moisture of the skin. Over time this damage leads to characteristic signs that make the skin look older: altered facial contour, sagging skin, wrinkles, and an uneven complexion...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29133982/combined-aesthetic-interventions-for-prevention-of-facial-ageing-and-restoration-and-beautification-of-face-and-body
#12
Sabrina Fabi, Tatjana Pavicic, André Braz, Jeremy B Green, Kyle Seo, Jani Aj van Loghem
The Merz Institute of Advanced Aesthetics Expert Summit was held in Prague, Czech Republic, from 19-20 November 2016. The meeting had a distinct advisory board character and invited aesthetic practitioners from all over the world to hear an international faculty present a range of keynote lectures and conduct live injection sessions with an emphasis on recent developments in combination aesthetic interventions for face and body rejuvenation and beautification. Aging is associated with changes in bones, muscles, ligaments, adipose tissue, and skin and, moreover, involves interactions among these tissue types...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29089780/tailored-botulinum-toxin-type-a-injections-in-aesthetic-medicine-consensus-panel-recommendations-for-treating-the-forehead-based-on-individual-facial-anatomy-and-muscle-tone
#13
Javier Anido, Daniel Arenas, Cristina Arruabarrena, Alfonso Domínguez-Gil, Carlos Fajardo, Mar Mira, Javier Murillo, Natalia Ribé, Helga Rivera, Sofia Ruiz Del Cueto, Helder Silvestre, Marisa Tirado
BACKGROUND: Facial lines and wrinkles are strongly influenced by individual differences in anatomy and muscle activity and no single injection protocol will suit all patients. However, there is only limited information in the published literature on how to develop a tailored approach to botulinum toxin treatment. METHODS: An expert panel of physicians was convened to establish a consensus on developing an individualized approach to treatment of the forehead with incobotulinumtoxinA...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29042806/feeding-filaggrin-effects-of-l-histidine-supplementation-in-atopic-dermatitis
#14
Siao Pei Tan, Simon B Brown, Christopher Em Griffiths, Richard B Weller, Neil K Gibbs
Atopic dermatitis (AD), also known as eczema, is one of the most common chronic skin conditions worldwide, affecting up to 16% of children and 10% of adults. It is incurable and has significant psychosocial and economic impacts on the affected individuals. AD etiology has been linked to deficiencies in the skin barrier protein, filaggrin. In mammalian skin, l-histidine is rapidly incorporated into filaggrin. Subsequent filaggrin proteolysis releases l-histidine as an important natural moisturizing factor (NMF)...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29042805/efficacy-of-the-combined-use-of-a-mild-foaming-cleanser-and-moisturizer-for-the-care-of-infant-skin
#15
Naoko Okamoto, Kaori Umehara, Junko Sonoda, Mitsuyuki Hotta, Hiroki Mizushima, Yutaka Takagi, Keiko Matsuo, Naoko Baba
OBJECTIVE: Despite the application of skin care treatments, many infants have skin problems such as dryness and erythema. We proposed a new combination skin care for infants which consisted of a foaming cleanser with lower surfactant activity and moisturizers that contained pseudo-ceramide. SUBJECTS AND METHODS: A total of 50 infants (age: 3-24 months) with insignificant levels of dry skin were enrolled in this usage trial. The parents washed the infants with the test cleanser while bathing and then applied the moisturizer (lotion or cream) containing pseudo-ceramide...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29033598/calcipotriene-betamethasone-dipropionate-for-the-treatment-of-psoriasis-vulgaris-an-evidence-based-review
#16
REVIEW
Nupur U Patel, Kayla Felix, Danielle Reimer, Steven R Feldman
While topical medications remain the cornerstone of the psoriasis treatment paradigm, they also come with the risk of multiple side effects. An alternative topical treatment option, calcipotriene or calcipotriol, is a vitamin D derivative that is thought to work by inhibiting keratinocyte proliferation and enhancing keratinocyte differentiation. Multiple studies have demonstrated its efficacy and safety in improving psoriasis when used in combination with topical corticosteroids. Given the effectiveness and side effect profile seen with this combination of topical steroid and calcipotriene, the US Food and Drug Administration approved a calcipotriene/betamethasone dipropionate product for use in psoriasis patients over the age of 12 in 2006...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28989281/efficacy-and-tolerability-of-liposomal-polyvinylpyrrolidone-iodine-hydrogel-for-the-localized-treatment-of-chronic-infective-inflammatory-dermatoses-an-uncontrolled-pilot-study
#17
Matthias Augustin, Lisa Goepel, Arnd Jacobi, Bjoern Bosse, Stefan Mueller, Michael Hopp
Infection is common in many chronic, inflammatory skin conditions but is often difficult to treat, in part due to growing bacterial resistance to antibiotics. Liposomal polyvinyl-pyrrolidone (PVP)-iodine hydrogel has a unique mode of action, combining the antiseptic and anti-inflammatory actions of PVP-iodine with the drug delivery and moisturizing properties of liposomes. We investigated the utility of liposomal PVP-iodine to treat infective dermatoses. In this prospective, single-arm (uncontrolled), open-label Phase II pilot study, patients with acne vulgaris (n=30), atopic dermatitis (n=20), impetigo contagiosa (n=10), and rosacea (n=10) received PVP-iodine (3%) hydrogel for ≤4 weeks...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28979153/novel-phytoceramides-containing-fatty-acids-of-diverse-chain-lengths-are-better-than-a-single-c18-ceramide-n-stearoyl-phytosphingosine-to-improve-the-physiological-properties-of-human-stratum-corneum
#18
Myoung Jin Oh, Young Hoon Cho, So Yoon Cha, Eun Ok Lee, Jin Wook Kim, Sun Ki Kim, Chang Seo Park
Ceramides in the human stratum corneum (SC) are a mixture of diverse N-acylated fatty acids (FAs) with different chain lengths. C24 is the major class of FAs of ceramides. However, there are also other classes of ceramides with diverse chain lengths of FAs, and these lengths generally range from C16 to C26. This study aimed to prepare several types of phytoceramide containing diverse chain lengths of N-acylated FAs and compare them with C18-ceramide N-stearoyl phytosphingosine (NP) in terms of their effects on the physiological properties of the SC...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28932126/dermopathy-associated-with-cetuximab-and-panitumumab-investigation-of-the-usefulness-of-moisturizers-in-its-management
#19
Shoichi Watanabe, Motoki Nakamura, Hiroki Takahashi, Masayasu Hara, Kei Ijichi, Daisuke Kawakita, Akimichi Morita
AIMS: Limited data regarding the objective evaluation of skin exsiccation caused by epidermal growth factor receptor (EGFR) inhibitors exist. Objective indices were applied to evaluate the usefulness of a moisturizer against skin exsiccation associated with the use of EGFR inhibitors in cancer patients. PATIENTS AND METHODS: Patients with either colorectal or head and neck cancer treated with either cetuximab or panitumumab were randomly assigned 1:2 to the prophylactic-treatment arm, where participants received prophylactical moisturizer treatment (heparinoid preparation, Hirudoid(®)), or to the symptomatic-treatment arm, where moisturizer was applied after the onset of cutaneous symptoms...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28932125/an-empirically-generated-responder-definition-for-rosacea-treatment
#20
Gerald Staedtler, Kaweh Shakery, Jan Endrikat, Richard Nkulikiyinka, Christoph Gerlinger
OBJECTIVE: The aim of this study was to empirically generate a responder definition for the treatment of papulopustular rosacea. METHODS: A total of 8 multicenter clinical studies on patients with papulopustular facial rosacea were analyzed. All patients were treated with azelaic acid and/or comparator treatments. The severity of rosacea was described by the Investigator Global Assessment (IGA) and the number of lesions. Patients with the IGA score of "clear/minimal" were considered as responders, and those staying in the range of IGA "mild to severe" as nonresponders...
2017: Clinical, Cosmetic and Investigational Dermatology
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