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Clinical, Cosmetic and Investigational Dermatology

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https://www.readbyqxmd.com/read/27920565/electrochemotherapy-induces-apoptotic-death-in-melanoma-metastases-a-histologic-and-immunohistochemical-investigation
#1
Laura Bigi, Giovanna Galdo, Anna Maria Cesinaro, Cristina Vaschieri, Alessandra Marconi, Carlo Pincelli, Fabrizio Fantini
BACKGROUND: Electrochemotherapy (ECT) is increasingly used in the treatment of primary and secondary skin tumors, but little is known about the pathologic mechanism responsible for tumor cell destruction in humans. Knowledge of detailed mechanism of host response after ECT may improve the treatment efficacy related to patient selection and technique refinements. AIM: The aim of the study was to investigate the histopathology and mechanism of cell death after ECT in cutaneous melanoma metastases...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27877062/systemic-abnormalities-of-psoriatic-patients-a-retrospective-study
#2
Li Yin, Jia-Li Xu, Ying-Ying Hu, Andrew Johnston, Zhi-Qiang Yin
BACKGROUND: Psoriasis is a chronic immune-mediated inflammatory disease related to the metabolic syndrome, cardiovascular disease, and other comorbidities. However, so far there has been no specific research concerning systemic abnormalities in psoriatic patients. OBJECTIVE: A retrospective study was conducted focusing on the detailed systemic abnormalities in psoriatic patients. METHODS: Psoriatic inpatients data was collected from July 2009 to September 2015...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27877061/aloe-sterol-supplementation-improves-skin-elasticity-in-japanese-men-with-sunlight-exposed-skin-a-12-week-double-blind-randomized-controlled-trial
#3
Miyuki Tanaka, Yuki Yamamoto, Eriko Misawa, Kazumi Nabeshima, Marie Saito, Koji Yamauchi, Fumiaki Abe, Fukumi Furukawa
BACKGROUND/OBJECTIVE: Recently, it was confirmed that the daily oral intake of plant sterols of Aloe vera gel (Aloe sterol) significantly increases the skin barrier function, moisture, and elasticity in photoprotected skin. This study aimed to investigate whether Aloe sterol intake affected skin conditions following sunlight exposure in Japanese men. METHODS: We performed a 12-week, randomized, double-blind, placebo-controlled study to evaluate the effects of oral Aloe sterol supplementation on skin conditions in 48 apparently healthy men (age range: 30-59 years; average: 45 years)...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27877060/anti-inflammatory-and-immunomodulatory-effects-of-aquaphilus-dolomiae-extract-on-in-vitro-models
#4
Marie-Françoise Aries, Hélène Hernandez-Pigeon, Clémence Vaissière, Hélène Delga, Antony Caruana, Marguerite Lévêque, Muriel Bourrain, Katia Ravard Helffer, Bertrand Chol, Thien Nguyen, Sandrine Bessou-Touya, Nathalie Castex-Rizzi
BACKGROUND: Atopic dermatitis (AD) is a common skin disease characterized by recurrent pruritic inflammatory skin lesions resulting from structural and immune defects of the skin barrier. Previous studies have shown the clinical efficacy of Avène thermal spring water in AD, and a new microorganism, Aquaphilus dolomiae was suspected to contribute to these unique properties. The present study evaluated the anti-inflammatory, antipruritic, and immunomodulatory properties of ES0, an original biological extract of A...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27877059/skin-rejuvenation-using-cosmetic-products-containing-growth-factors-cytokines-and-matrikines-a-review-of-the-literature
#5
REVIEW
Caroline Aldag, Diana Nogueira Teixeira, Phillip S Leventhal
Skin aging is primarily due to alterations in the dermal extracellular matrix, especially a decrease in collagen I content, fragmentation of collagen fibrils, and accumulation of amorphous elastin material, also known as elastosis. Growth factors and cytokines are included in several cosmetic products intended for skin rejuvenation because of their ability to promote collagen synthesis. Matrikines and matrikine-like peptides offer the advantage of growth factor-like activities but better skin penetration due to their much smaller molecular size...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27853385/efficacy-of-ingenol-mebutate-gel-for-actinic-keratosis-in-patients-treated-by-thiazide-diuretics
#6
Elena Campione, Monia Di Prete, Laura Diluvio, Luca Bianchi, Augusto Orlandi
Actinic keratosis (AK) is considered as superficial squamous cell carcinoma. Chronic sun exposure plays a central role in its pathogenesis. In particular, ultraviolet B radiation causes direct damage to the DNA, producing pyrimidine dimers that suppress the protective role of p53. Other risk factors include advanced age, male sex, and fair skin type. Even some drugs used for treating blood hypertension, such as thiazide diuretics, can increase the risk of developing AK. Their photosensitizing action seems to be connected with reactive oxygen species production...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27843333/water-soluble-egg-membrane-enhances-the-immunoactivating-properties-of-an-aloe-vera-based-extract-of-nerium-oleander-leaves
#7
Kathleen F Benson, Robert A Newman, Gitte S Jensen
OBJECTIVE: To evaluate a blend of two natural ingredients on immune parameters relevant for their current topical use and potential support of microcirculation in skin tissue. MATERIALS AND METHODS: A blend (BL) of Aloe vera-based Nerium oleander extract (NAE-8i, oleandrin-free) and hydrolyzed water-soluble egg membrane (WSEM) was applied to human whole-blood cultures for 24 hours, with each separate ingredient serving as a control. Immune-cell subsets were analyzed for expression levels of the activation markers CD69 and CD25...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27799808/the-psychosocial-impact-of-acne-vitiligo-and-psoriasis-a-review
#8
REVIEW
Catherine M Nguyen, Kourosh Beroukhim, Melissa J Danesh, Aline Babikian, John Koo, Argentina Leon
INTRODUCTION: Chronic skin conditions have been well reported to affect a patient's quality of life on multiple dimensions, including the psychosocial domain. Psychosocial is defined as the interrelation of social factors with an individual's thoughts and behavior. The assessment of the psychosocial impact of skin disease on a patient can help direct the dermatologists' treatment goals. To evaluate the psychosocial impact of skin disease, we conducted a review of the literature on three skin conditions with onsets at various stages of life: acne, vitiligo, and psoriasis...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27799807/safety-and-performance-of-cohesive-polydensified-matrix-hyaluronic-acid-fillers-with-lidocaine-in-the-clinical-setting-an-open-label-multicenter-study
#9
Ulrich Kühne, Jørgen Esmann, Dennis von Heimburg, Matthias Imhof, Petra Weissenberger, Gerhard Sattler
Cohesive polydensified matrix (CPM(®)) hyaluronic acid fillers are now available with or without lidocaine. The aim of this study was to investigate the safety and performance of CPM(®) fillers with lidocaine in the clinical setting. In an open-label, prospective, postmarketing study, 108 patients from seven sites in Germany and Denmark were treated with one or more lidocaine-containing CPM(®) fillers. Performance was assessed using the Merz Aesthetics Scales(®) (MAS). Pain was rated on an 11-point visual analog scale...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27799806/spotlight-on-adalimumab-in-the-treatment-of-active-moderate-to-severe-hidradenitis-suppurativa
#10
REVIEW
Christina Fotiadou, Efstratios Vakirlis, Dimitrios Ioannides
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease that affects the hair follicles of the aprocrine gland-bearing anatomical areas of the body. It is characterized by deep painful nodules and abscesses that rupture and contribute to the formation of sinus tracks and scarring. The management of HS is based on the assessment of disease severity and a combination of medical and surgical treatment according to the European Guidelines. Adalimumab, a recombinant, fully humanized, anti-tumor necrosis factor alpha (anti-TNF-α) monoclonal antibody, is the only officially approved treatment for the management of moderate-to-severe HS...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27799805/clinical-effects-of-an-oral-supplement-rich-in-antioxidants-on-skin-radiance-in-women
#11
Marion Dumoulin, David Gaudout, Benoit Lemaire
BACKGROUND: Environmental factors impact the skin aging resulting in decrease of skin radiance. Nutrition and particularly antioxidants could help to fight against skin degradation. OBJECTIVE: The aim of this study was to evaluate the effects of an oral supplement rich in specific antioxidants, SkinAx(2TM), on the improvement of the skin radiance in women. METHODS: The open-label clinical study enrolled 35 women, aged 40-70, with facial dull complexion...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27789968/reduction-of-facial-wrinkles-by-hydrolyzed-water-soluble-egg-membrane-associated-with-reduction-of-free-radical-stress-and-support-of-matrix-production-by-dermal-fibroblasts
#12
Gitte S Jensen, Bijal Shah, Robert Holtz, Ashok Patel, Donald C Lo
OBJECTIVE: The aim of this study was to evaluate the effects of water-soluble egg membrane (WSEM) on wrinkle reduction in a clinical pilot study and to elucidate specific mechanisms of action using primary human immune and dermal cell-based bioassays. METHODS: To evaluate the effects of topical application of WSEM (8%) on human skin, an open-label 8-week study was performed involving 20 healthy females between the age of 45 years and 65 years. High-resolution photography and digital analysis were used to evaluate the wrinkle depth in the facial skin areas beside the eye (crow's feet)...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27789967/hard-water-softening-effect-of-a-baby-cleanser
#13
Russel M Walters, Emmanuel Anim-Danso, Stephanie M Amato, Kimberly A Capone, M Catherine Mack, Lorena S Telofski, David A Mays
BACKGROUND: Hard water is associated with atopic dermatitis (eczema). We wanted to determine if a baby cleanser and its individual components altered free ionized calcium (Ca(2+)) in a simulated hard water baby bath. For these studies, an in vitro determination of free Ca(2+) in a simulated hard water baby bath, and an in vivo exploratory study of free Ca(2+) absorption into skin from hard water were performed. METHODS: Free Ca(2+) was measured with an ion-sensitive electrode in vitro in hard water (100-500 ppm, Ca(2+)) before and after addition of the cleanser and/or its components...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27785085/treatment-challenges-in-the-management-of-moderate-to-severe-plaque-psoriasis-role-of-secukinumab
#14
REVIEW
Mona Malakouti, Sharon E Jacob, Nancy J Anderson
Psoriasis is a chronic inflammatory skin disease that has a negative impact on psychosocial well-being and cardiometabolic health. Treatment options for moderate-to-severe psoriasis have expanded with the development of interleukin-17 (IL-17) inhibitors, the first of which is now available - secukinumab. Secukinumab is a fully human monoclonal immunoglobulin G1 κ antibody that selectively inhibits the ligand IL-17A. In head-to-head studies, it is more effective than etanercept and ustekinumab, particularly in achieving Psoriasis Area and Severity Index (PASI) 90/100 and achieving PASI 50/75 as early as week 4...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27785084/effectiveness-of-topical-peppermint-oil-on-symptomatic-treatment-of-chronic-pruritus
#15
Lotfy T Elsaie, Abdelraouf M El Mohsen, Ibrahim M Ibrahim, Mahmoud H Mohey-Eddin, Mohamed L Elsaie
BACKGROUND: Pruritus is one of the commonest skin complaints. Peppermint oil can be effective in reducing the severity of such a condition. AIM: The aim of this study was to assess the efficacy of topically applied peppermint oil in the treatment of chronic pruritus. SUBJECTS AND METHODS: Fifty selected subjects diagnosed with chronic pruritus due to hepatic, renal, or diabetic cause were studied and divided into two groups of 25 patients each...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27785083/overall-skin-tone-and-skin-lightening-improving-effects-with-oral-supplementation-of-lutein-and-zeaxanthin-isomers-a-double-blind-placebo-controlled-clinical-trial
#16
Vijaya Juturu, James P Bowman, Jayant Deshpande
PURPOSE: Carotenoids, especially lutein and zeaxanthin isomers (L/Zi), filter blue light and protect skin from environmental factors including high-energy sources. These carotenoids may be able to block the formation of melanin pathways, decrease cytokines, and increase antioxidants. SUBJECTS AND METHODS: This is a randomized, double-blind, placebo-controlled clinical trial over a 12-week supplementation period. Fifty healthy people (50 healthy subjects were recruited and 46 subjects completed the study) (males and females, age: 18-45 years) with mild-to-moderate dry skin were included in this study...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27785082/tolerability-and-camouflaging-effect-of-corrective-makeup-for-acne-results-of-a-clinical-study-of-a-novel-face-compact-cream
#17
Giuseppe Monfrecola, Sara Cacciapuoti, Claudia Capasso, Mario Delfino, Gabriella Fabbrocini
BACKGROUND: A novel face compact cream (FCC) containing a new patented formulation was recently developed to provide acne patients with cosmetic camouflage for their lesions and to have beneficial effects on the multifactorial components of the disease. This pilot investigation aimed to evaluate the real-life tolerability, potential for comedogenicity and covering effect provided by this FCC. METHODS: This single-center study evaluated the FCC applied once daily for 28 days in 20 females with facial acne...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27729809/paraneoplastic-pemphigus-a-short-review
#18
Marta Wieczorek, Annette Czernik
Paraneoplastic pemphigus (PNP) is a fatal autoimmune blistering disease associated with an underlying malignancy. It is a newly recognized blistering disease, which was first recognized in 1990 by Dr Anhalt who described an atypical pemphigus with associated neoplasia. In 2001, Nguyen proposed the term paraneoplastic autoimmune multiorgan syndrome because of the recognition that the condition affects multiple organ systems. PNP presents most frequently between 45 and 70 years old, but it also occurs in children and adolescents...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27713647/efficacy-and-tolerance-of-an-injectable-medical-device-containing-stable-hybrid-cooperative-complexes-of-high-and-low-molecular-weight-hyaluronic-acid-a-monocentric-16-weeks-open-label-evaluation
#19
Adele Sparavigna, Beatrice Tenconi
BACKGROUND: An injectable medical device containing stable hybrid cooperative complexes of high- and low-molecular-weight hyaluronic acid (HA) has been developed with characteristics suited for a global improvement of facial esthetics. OBJECTIVE: To evaluate the HA product performance in improving some key facial esthetic features. The study employed clinical scales, subjective evaluations, and facial skin objective measurements. METHODS: A single Italian site treated 64 female subjects aged 38-60 years, with injections at five predetermined points, on each side of the face, with a 4-week time lapse between the first and the second product administration...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27695354/management-of-familial-benign-chronic-pemphigus
#20
Harleen Arora, Fleta N Bray, Jessica Cervantes, Leyre A Falto Aizpurua
Benign familial chronic pemphigus or Hailey-Hailey disease is caused by an autosomal dominant mutation in the ATP2C1 gene leading to suprabasilar acantholysis. The disease most commonly affects intertriginous areas symmetrically. The chronic nature of the disease and multiple recurrences make the disease bothersome for patients and a treatment challenge for physicians. Treatments include topical and/or systemic agents and surgery including laser. This review summarizes the available treatment options.
2016: Clinical, Cosmetic and Investigational Dermatology
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