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Neurology Research International

Jegan Sakthivel Nadar, Pravin Popatrao Kale, Pramod Kerunath Kadu, Kedar Prabhavalkar, Ruchita Dhangar
Hesperidin, a well-known flavanone glycoside mostly found in citrus fruits, showed neuroprotective and antidepressant activity. Agomelatine, a melatonergic MT1 /MT2 agonist and 5-HT2C receptor antagonist, exhibits good antidepressant efficacy. Bupropion has been widely used for the treatment of depression because of its dopamine and norepinephrine reuptake inhibition. The objective of present study was to assess the antidepressant effects of hesperidin combination with agomelatine or bupropion. Male Swiss Albino mice received treatment of saline, vehicle, 'hesperidin alone', 'agomelatine alone', hesperidin+agomelatine, 'bupropion alone', hesperidin+bupropion, and agomelatine+bupropion for 14 days...
2018: Neurology Research International
Emily R Rosario, Stephanie E Kaplan, Sepehr Khonsari, Garrett Vazquez, Niyant Solanki, Melanie Lane, Hiriam Brownell, Sheila S Rosenberg
Background: While research suggests a benefit of hyperbaric oxygen therapy (HBOT) for neurologic injury, controlled clinical trials have not been able to clearly define the benefits. Objective: To investigate the effects of HBOT on physical and cognitive impairments resulting from an ischemic stroke. Methods: Using a within-subject design a baseline for current functional abilities was established over a 3-month period for all subjects (n=7)...
2018: Neurology Research International
Ali M Al Khathaami, Haya Aloraini, S Almudlej, Haifa Al Issa, Nourhan Elshammaa, Sami Alsolamy
Background and Objectives: Tissue plasminogen activator (t-PA) within 4.5 hours from onset improves outcome in patients with ischemic stroke and has been recommended by several international guidelines. Since its approval in 1996, the debate among emergency physicians continues particularly around the result interpretation of the first positive randomized controlled trial, the National Institute of Neurological Disorders and Stroke (NINDS) clinical trial. This lack of consensus might negatively affect the delivery of effective stroke care...
2018: Neurology Research International
Jean-Baptiste Delmotte, Abdulkarim Tutakhail, Kahina Abdallah, Pauline Reach, Marguerite D'Ussel, Gael Deplanque, Hélène Beaussier, François Coudoré
Purpose: Oxaliplatin is a platinum compound widely used in gastrointestinal cancer treatment but produces dose-limiting peripheral neuropathy. New insights into oxaliplatin-induced peripheral neuropathy (OIPN) assessment are needed to detect more effectively this condition. In this context, we conducted Canaloxa study, a prospective preliminary clinical trial that aimed to investigate how Electrochemical Skin Conductance (ESC), a parameter used in small fiber neuropathy assessment, could be helpful in OIPN diagnosis...
2018: Neurology Research International
Mohammed Saeed Alqahtani, Ahmad Ayed Alshbriqe, Ahmed A Awwadh, Turki Ali Alyami, Mohammed Saad Alshomrani, Adel Alhazzani
Objectives: To identify prevalence and risk factors of depression among caregivers of Alzheimer' disease (AD) patients. Methods: In a cross-sectional study, 110 caregivers of AD patients participated in this study (51 males and 59 females). Patients data were obtained from patients' records at Aseer Central Hospital. Depression among caregivers was assessed by using the Hamilton Rating Scale for Depression. Results: The age of caregivers ranged from 17 to 85 years (Mean±SD: 41...
2018: Neurology Research International
Gizachew Kassahun, Getachew Moges, Yitayew Demessie
An epileptic seizure is a clinical event presumed to result from an abnormal and excessive neuronal discharge. The clinical symptoms are paroxysmal and may include impaired consciousness and motor, sensory, autonomic, or psychic events perceived by the subject or an observer. Epilepsy occurs when 2 or more epileptic seizures occur unprovoked by any immediately identifiable cause. And in the majority of patients with epilepsy, antiepileptic drugs effectively control their illness. However, more than 30% of people with epilepsy do not attain full seizure control, even with the best available treatment regimen...
2018: Neurology Research International
Jocelyn Y Cheng
Purpose: Positive airway pressure remains the gold-standard treatment for OSA, but many are intolerant. The neurotransmitter serotonin is involved in respiratory control. Evidence exists for SRIs in reducing OSA severity in the general population and ictal hypoxemia and seizure-induced respiratory arrest in people with epilepsy (PWE). However, the association between SRIs and OSA severity has not been studied in populations consisting of both groups. This study aims to determine if SRIs are associated with OSA severity in both PWE and people without epilepsy (PWO) and whether differences exist between the two groups...
2018: Neurology Research International
Stephen Albano, Blake Berman, Glenn Fischberg, Javed Siddiqi, Bolin Liu, Yasir Khan, Atif Zafar, Syed A Quadri, Mudassir Farooqui
Background: Nosocomial EVD-related ventriculitis is a major complication and a significant cause of morbidity and mortality in critically ill neurological patients. Questions remain about best management of EVDs. The purpose of this study is to compare our incidence of ventriculitis to studies using different catheters and/or antibiotic coverage schemes and determine whether c-EVD with prolonged antibiotics given for the duration of drain placement is inferior to ac-EVD with pp-abx or ac-EVD with prolonged antibiotics for prevention of ventriculitis...
2018: Neurology Research International
Osama A Khairoalsindi, Ahmad R Abuzinadah
Amyotrophic lateral sclerosis is a neurodegenerative disease that leads to loss of the upper and lower motor neurons. Almost 90% of all cases occur in the sporadic form, with the rest occurring in the familial form. The disease has a poor prognosis, with only two disease-modifying drugs approved by the United States Food and Drug Administration (FDA). The approved drugs for the disease have very limited survival benefits. Edaravone is a new FDA-approved medication that may slow the disease progression by 33% in a selected subgroup of ALS patients...
2018: Neurology Research International
Hanan Amer, Hatem Shehata, Laila Ahmed Rashed, Hanan Helmy, Shaimaa El-Jaafary, Asmaa Sabbah, Wael Ibrahim
No abstract text is available yet for this article.
2018: Neurology Research International
Mahdi Habibi-Koolaee, Leila Shahmoradi, Sharareh R Niakan Kalhori, Hossein Ghannadan, Erfan Younesi
Background: Stroke is a leading cause of death and disability worldwide. According to the Iranian Ministry of Medical Health and Education, out of 100,000 stroke incidents in the country, 25,000 lead to death. Thus, identifying risk factors of stroke can help healthcare providers to establish prevention strategies. This study was conducted to investigate the prevalence of stroke risk factors and their distribution based on stroke subtypes in Sayad Shirazi Hospital, Gorgan, Northeastern Iran...
2018: Neurology Research International
Mohamed E Khallaf
Background: In individuals with hemiparetic stroke, reaching with the paretic arm can be impaired by abnormal muscle coactivation. Prior trails for improving upper extremity functions after stroke have underestimated the role of gravitational force in motor planning and execution. Objective: The aims this trial were to study the effect of gravity as a facilitator for elbow extension and to estimate the immediate and retention effects of task specific training of elbow extensors on upper extremity function after stroke...
2018: Neurology Research International
Cansu Köseoğlu Toksoy, Cem Bölük, Ülkü Türk Börü, Seydahmet Akın, Abdullah Yasir Yılmaz, Sanem Coşkun Duman, Mustafa Taşdemir
Background: This study aims to determine the stroke prevalence in Akçakoca which is a rural area in Turkey. Methods: The study was designed as a cross-sectional, door-to-door survey. The stroke questionnaire was completed by a trained team in the presence of the participants according to their answers. Based on the screenings, patients who had been diagnosed with stroke previously were reexamined by a neurologist and determined the prevalence values, risk factors, and stroke types...
2018: Neurology Research International
Jisu Elsa Jacob, Gopakumar Kuttappan Nair, Thomas Iype, Ajith Cherian
EEG analysis in the field of neurology is customarily done using frequency domain methods like fast Fourier transform. A complex biomedical signal such as EEG is best analysed using a time-frequency algorithm. Wavelet decomposition based analysis is a relatively novel area in EEG analysis and for extracting its subbands. This work aims at exploring the use of discrete wavelet transform for extracting EEG subbands in encephalopathy. The subband energies were then calculated and given as feature sets to SVM classifier for identifying cases of encephalopathy from normal healthy subjects...
2018: Neurology Research International
Marcelo de Lima Oliveira, Angela Macedo Salinet, Ricardo de Carvalho Nogueira, Alessandro Rodrigo Belon, Wellingson Silva Paiva, Brasil Chian Ping Jeng, Manoel Jacobsen Teixeira, Edson Bor-Seng-Shu
Background: This study aimed to analyse cerebral autoregulation (CA) during induction and treatment of intracranial hypertension (ICH) in an experimental model. Materials and Methods: Landrace and Duroc piglets were divided into mild and severe ICH groups. Four or seven millilitres of saline solution was infused into paediatric bladder catheter inserted in the parietal lobe (balloon inflation). After 1.5 h, a 3% saline solution was infused via venous catheter, and 30 min later, the bladder catheter balloon was deflated (surgery)...
2018: Neurology Research International
Jisu Elsa Jacob, Ajith Cherian, K Gopakumar, Thomas Iype, Doris George Yohannan, K P Divya
Chaotic analysis is a relatively novel area in the study of physiological signals. Chaotic features of electroencephalogram have been analyzed in various disease states like epilepsy, Alzheimer's disease, sleep disorders, and depression. All these diseases have primary involvement of the brain. Our study examines the chaotic parameters in metabolic encephalopathy, where the brain functions are involved secondary to a metabolic disturbance. Our analysis clearly showed significant lower values for chaotic parameters, correlation dimension, and largest Lyapunov exponent for EEG in patients with metabolic encephalopathy compared to normal EEG...
2018: Neurology Research International
Mohammad-Amin Khajezadeh, Gholamreza Zamani, Bobak Moazzami, Zahra Nagahi, Mahdie Mousavi-Torshizi, Vahid Ziaee
Objective: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by multisystem involvement, including the nervous system. In the present study, we aimed to assess neuropsychiatric manifestations in juvenile-onset systemic lupus erythematosus (JSLE) in Iran. Methods: One hundred and forty-six pediatric onset patients with SLE who had registered in our pediatric rheumatology database were evaluated prospectively and cross sectionally within 2013-2015...
2018: Neurology Research International
Monsicha Ngampoopun, Piradee Suwanpakdee, Nattapon Jaisupa, Charcrin Nabangchang
Nonconvulsive status epilepticus (NCSE) and acute repetitive seizures (ARS) are associated with significant morbidity and mortality. Due to the lack of randomized-controlled trials of intravenous antiepileptic drugs (AEDs) in these conditions, trials of a new generation of AEDs in this aspect are needed. A prospective interventional study was conducted in children under 18 years of age with NCSE or ARS who either had contraindication to or were refractory to first-line AEDs and received intravenous lacosamide...
2018: Neurology Research International
Urai Kummarg, Siriorn Sindhu, Sombat Muengtaweepongsa
Background: Intravenous recombinant tissue plasminogen activator (i.v. rt-PA) is the milestone treatment for patients with acute ischemic stroke. Stroke Fast Track (SFT) facilitates time reduction, guarantees safety, and promotes good clinical outcomes in i.v. rt-PA treatment. Nursing case management is a healthcare service providing clinical benefits in many specific diseases. The knowledge about the efficacy of a nurse case management for Stroke Fast Track is limited. We aim to study the effect of nurse case management on clinical outcomes in patients with acute ischemic stroke involving intravenous recombinant tissue plasminogen activator (i...
2018: Neurology Research International
Jéssica Lopes de Souza, Aline Scardoeli Faiola, Carmen Silvia Molleis Galego Miziara, Maria Luiza Giraldes de Manreza
Objective: To evaluate the perceived social stigma of people with epilepsy with regard to the question of employability. Methods: A structured questionnaire was given to two groups of people with chronic diseases: those with epilepsy (study group) and those with heart disease (control group). The questions concerned employability. Results: Having epilepsy was more strongly associated with higher unemployment rates ( p < 0.0001); job layoffs ( p = 0...
2018: Neurology Research International
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