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Neurology Research International

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https://www.readbyqxmd.com/read/28630769/comparing-the-expression-of-genes-related-to-serotonin-5-ht-in-c57bl-6j-mice-and-humans-based-on-data-available-at-the-allen-mouse-brain-atlas-and-allen-human-brain-atlas
#1
C A Acevedo-Triana, L A León, F P Cardenas
Brain atlases are tools based on comprehensive studies used to locate biological characteristics (structures, connections, proteins, and gene expression) in different regions of the brain. These atlases have been disseminated to the point where tools have been created to store, manage, and share the information they contain. This study used the data published by the Allen Mouse Brain Atlas (2004) for mice (C57BL/6J) and Allen Human Brain Atlas (2010) for humans (6 donors) to compare the expression of serotonin-related genes...
2017: Neurology Research International
https://www.readbyqxmd.com/read/28491476/increased-intracranial-pressure-in-the-setting-of-enterovirus-and-other-viral-meningitides
#2
Jules C Beal
Increased intracranial pressure due to viral meningitis has not been widely discussed in the literature, although associations with Varicella and rarely Enterovirus have been described. Patients with increased intracranial pressure and cerebrospinal fluid analysis suggestive of a viral process are sometimes classified as having atypical idiopathic intracranial hypertension (IIH). However, a diagnosis of IIH requires normal cerebrospinal fluid, and therefore in these cases an infection with secondary intracranial hypertension may be a more likely diagnosis...
2017: Neurology Research International
https://www.readbyqxmd.com/read/28484650/efficacy-of-keyhole-approach-to-carpal-tunnel-syndrome-under-ambulatory-strategy
#3
Rodrigo Ramos-Zúñiga, César J García-Mercado, Iván Segura-Durán, Luis A Zepeda-Gutiérrez
The carpal tunnel syndrome is one of the most common entrapment neuropathies found in humans. Currently, the gold standard is surgical treatment using different modalities. The minimally invasive strategy with high resolution capacity and less morbidity is still a challenge. Methods. Prospective nonrandomised clinical trial in which a minimally invasive microsurgical approach was used following the keyhole principle in 55 consecutive patients and 65 hands under local anesthesia and ambulatory strategy. They were evaluated with stringent inclusion criteria with the Levine severity and functional status scale and with a 2-year follow-up...
2017: Neurology Research International
https://www.readbyqxmd.com/read/28392943/report-from-a-survey-of-parents-regarding-the-use-of-cannabidiol-medicinal-cannabis-in-mexican-children-with-refractory-epilepsy
#4
Carlos G Aguirre-Velázquez
Structured online surveys were used to explore the experiences of the parents of children with refractory epilepsy using medicinal cannabis in Mexico during September 2016. The surveys, which were completed in full, were reviewed, and 53 cases of children aged between 9 months and 18 years were identified. Of these, 43 cases (82%) were from Mexico and 10 (18%) were from Latin American countries. Of the 43 Mexican cases, the diagnoses were as follows: 20 cases (47%) had Lennox-Gastaut syndrome (LGS); 13 cases (30%) had unspecified refractory epilepsy (URE); 8 cases (19%) had West syndrome (WS); 1 case (2%) had Doose syndrome (DS); and 1 case (2%) had Ohtahara syndrome (OS)...
2017: Neurology Research International
https://www.readbyqxmd.com/read/28210506/combined-supplementation-of-choline-and-docosahexaenoic-acid-during-pregnancy-enhances-neurodevelopment-of-fetal-hippocampus
#5
Huban Thomas Rajarethnem, Kumar Megur Ramakrishna Bhat, Malsawmzuali Jc, Siva Kumar Gopalkrishnan, Ramesh Babu Mugundhu Gopalram, Kiranmai Sesappa Rai
Choline is an essential nutrient for humans which plays an important role in structural integrity and signaling functions. Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid, highly enriched in cell membranes of the brain. Dietary intake of choline or DHA alone by pregnant mothers directly affects fetal brain development and function. But no studies show the efficacy of combined supplementation of choline and DHA on fetal neurodevelopment. The aim of the present study was to analyze fetal neurodevelopment on combined supplementation of pregnant dams with choline and DHA...
2017: Neurology Research International
https://www.readbyqxmd.com/read/28133547/accumulation-of-%C3%AE-synuclein-in-cerebellar-purkinje-cells-of-diabetic-rats-and-its-potential-relationship-with-inflammation-and-oxidative-stress-markers
#6
Volkan Solmaz, Hatice Köse Özlece, Hüseyin Avni Eroglu, Hüseyin Aktuğ, Oytun Erbaş, Dilek Taşkıran
Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar accumulation of α-synuclein in streptozotocin- (STZ-) induced diabetes model in rats. Methods. Twelve rats were included in the study. Diabetes (n = 6) was induced with a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). Diabetes was verified after 48 h by measuring blood glucose levels...
2017: Neurology Research International
https://www.readbyqxmd.com/read/28116158/remotely-assessing-symptoms-of-parkinson-s-disease-using-videoconferencing-a-feasibility-study
#7
Tereza Stillerova, Jacki Liddle, Louise Gustafsson, Robyn Lamont, Peter Silburn
Purpose. To evaluate the feasibility of assessing a person's symptoms of Parkinson's disease (PD) in their home using the videoconferencing technology they already possess, without a home visit. Method. Eleven participants with PD completed the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) face-to-face and then via videoconferencing within a two-week period. Participants used free software and the computers and webcams available at their home to complete the videoconference assessment with a clinical rater scoring remotely...
2016: Neurology Research International
https://www.readbyqxmd.com/read/28116157/protective-effect-of-ppar%C3%AE-agonists-on-cerebellar-tissues-oxidative-damage-in-hypothyroid-rats
#8
Yousef Baghcheghi, Farimah Beheshti, Hossein Salmani, Mohammad Soukhtanloo, Mahmoud Hosseini
The aim of the current study was to investigate the effects of peroxisome proliferator-activated receptor gamma (PPARγ) agonists on cerebellar tissues oxidative damage in hypothyroid rats. The animals included seven groups: group I (control), the animals received drinking water; group II, the animals received 0.05% propylthiouracil (PTU) in drinking water; besides PTU, the animals in groups III, IV, V, VI, and VII, were injected with 20 mg/kg vitamin E (Vit E), 10 or 20 mg/kg pioglitazone, and 2 or 4 mg/kg rosiglitazone, respectively...
2016: Neurology Research International
https://www.readbyqxmd.com/read/28018676/increased-serum-levels-of-tumor-necrosis-factor-alpha-resistin-and-visfatin-in-the-children-with-autism-spectrum-disorders-a-case-control-study
#9
Mohammad Ali Ghaffari, Elham Mousavinejad, Forough Riahi, Masoumeh Mousavinejad, Mohammad Reza Afsharmanesh
Background. Autism spectrum disorders (ASDs) are complex disorders where the pathogenesis is not fully understood. Several proinflammatory and immunoinflammatory disturbances have been observed in the etiology of ASD. There is, however, limited knowledge on variations of adipokines in ASD. The present study aimed to analyze the serum levels of resistin, visfatin, and tumor necrosis factor-alpha (TNF-α) in children with ASD in relation to body weight, gender, and ASD severity level. Method. In total, 30 children with ASD (mean age: 7...
2016: Neurology Research International
https://www.readbyqxmd.com/read/28018675/description-of-ictal-hfo-mapping-in-patients-with-both-temporal-and-extratemporal-seizure-focus
#10
Juan G Ochoa, Walter G Rusyniak
Objective. Review presurgical use of ictal HFO mapping to detect ictal activation areas with dual seizure focus in both the temporal and extratemporal cortex. Methods. Review of consecutive patients admitted to the University of South Alabama Epilepsy Monitoring Unit (SouthCEP) between January 2014 and October 2015, with suspected temporal lobe epilepsy and intracranial electrode recording. Ictal HFO localization was displayed in 3D reconstructed brain images using the patient's own coregistered magnetic resonance imaging (MRI) and computed tomography (CT) with the implanted electrodes...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27800180/cognitive-function-in-parkinson-s-disease-patients-with-and-without-anxiety
#11
K A Ehgoetz Martens, J Y Y Szeto, A J Muller, J M Hall, M Gilat, C C Walton, S J G Lewis
Research on the implications of anxiety in Parkinson's disease (PD) has been neglected despite its prevalence in nearly 50% of patients and its negative impact on quality of life. Previous reports have noted that neuropsychiatric symptoms impair cognitive performance in PD patients; however, to date, no study has directly compared PD patients with and without anxiety to examine the impact of anxiety on cognitive impairments in PD. This study compared cognitive performance across 50 PD participants with and without anxiety (17 PDA+; 33 PDA-), who underwent neurological and neuropsychological assessment...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27703812/assessment-and-predicting-factors-of-repeated-brain-computed-tomography-in-traumatic-brain-injury-patients-for-risk-stratified-care-management-a-5-year-retrospective-study
#12
Preeda Sumritpradit, Thitipong Setthalikhit, Sorayouth Chumnanvej
Background and Objective. To determine the value of repeated brain CT in TBI cases for risk-stratified care management (RSCM) and to identify predicting factors which will change the neurosurgical management after repeated brain CTs. Methods. A 5-year retrospective study from January 2009 to August 2013 was conducted. The primary outcome was the value of repeated brain CT in TBI cases. The secondary outcome is to identify predicting factors which will change the neurosurgical management after repeated brain CTs...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27642521/the-value-of-abcd2f-scoring-system-abcd2-combined-with-atrial-fibrillation-to-predict-90-day-recurrent-brain-stroke
#13
Mostafa Almasi, Nader Hodjati Firoozabadi, Faeze Ghasemi, Mojtaba Chardoli
Background. The ABCD2 score is now identified as a useful clinical prediction rule to determine the risk for stroke in the days following brain ischemic attacks. Aim. The present study aimed to introduce a new scoring system named "ABCD2F" and compare its value with the previous ABCD2 system to predict recurrent ischemic stroke within 90 days of the initial cerebrovascular accident (CVA). Methods. 138 consecutive patients with the final diagnosis of ischemic CVA or TIAs who referred to emergency ward of Rasoul-e-Akram general hospital in Tehran from September 2012 to December 2013 were eligible...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27547450/electrophysiological-predictors-of-clinical-outcome-in-traumatic-neuropathies-a-multicenter-prospective-study
#14
Palma Ciaramitaro, Mauro Mondelli, Eugenia Rota, Bruno Battiston, Arman Sard, Italo Pontini, Giuliano Faccani, Giuseppe Migliaretti, Aristide Merola, Dario Cocito, Italian Network For Traumatic Neuropathies
Objectives. This prospective, observational, multicentre study aims to identify electrodiagnostic (EDX) markers of clinical recovery in patients with traumatic neuropathy (TN) receiving surgical (S) and nonsurgical (NS) treatments. Methods. Subjects referred to the Italian Traumatic Neuropathy Network between 2010 and 2011 (307 patients, for a total of 444 TN) were evaluated with serial clinical/EDX evaluations at 6, 12, 24, and 36 months of follow-up. Results. Primary surgery was performed in 21 subjects with open lesions and evidence of neurotmesis, while closed lesions were treated with either conservative medical approach (216 patients) or secondary surgery (70 patients), according to the clinical spontaneous recovery at 4-6 months...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27525118/focusing-on-increasing-velocity-during-heavy-resistance-knee-flexion-exercise-boosts-hamstring-muscle-activity-in-chronic-stroke-patients
#15
Jonas Vinstrup, Joaquin Calatayud, Markus D Jakobsen, Emil Sundstrup, Lars L Andersen
Background. Muscle strength is markedly reduced in stroke patients, which has negative implications for functional capacity and work ability. Different types of feedback during strength training exercises may alter neuromuscular activity and functional gains. Objective. To compare levels of muscle activity during conditions of blindfolding and intended high contraction speed with a normal condition of high-intensity knee flexions. Methods. Eighteen patients performed unilateral machine knee flexions with a 10-repetition maximum load...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27313890/peripheral-nerve-ultrasonography-in-chronic-inflammatory-demyelinating-polyradiculoneuropathy-and-multifocal-motor-neuropathy-correlations-with-clinical-and-neurophysiological-data
#16
Aristide Merola, Michela Rosso, Alberto Romagnolo, Erdita Peci, Dario Cocito
Objective. This cross-sectional study analyzes the pattern of ultrasound peripheral nerve alterations in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN) at different stages of functional disability. Material and Methods. 22 CIDP and 10 MMN patients and a group of 70 healthy controls were evaluated with an ultrasound scan of the median, ulnar, peroneal, tibial, and sural nerves. Results were correlated with clinical disability scales and nerve conduction studies...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27298735/the-potential-of-curcumin-in-treatment-of-spinal-cord-injury
#17
REVIEW
Raghavendra Sanivarapu, Vijayalakshmi Vallabhaneni, Vivek Verma
Current treatment for spinal cord injury (SCI) is supportive at best; despite great efforts, the lack of better treatment solutions looms large on neurological science and medicine. Curcumin, the active ingredient in turmeric, a spice known for its medicinal and anti-inflammatory properties, has been validated to harbor immense effects for a multitude of inflammatory-based diseases. However, to date there has not been a review on curcumin's effects on SCI. Herein, we systematically review all known data on this topic and juxtapose results of curcumin with standard therapies such as corticosteroids...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27239341/utility-of-plasmapheresis-in-autoimmune-mediated-encephalopathy-in-children-potentials-and-challenges
#18
REVIEW
Abdulhafeez M Khair
Autoimmune-mediated encephalopathy in children continues to constitute a diagnostic and therapeutic challenge in pediatric population. Utility and usefulness in this clinical setting of plasmapheresis have seldom been evaluated in current pediatric literature. Children with immune-mediated encephalopathies represent a uniquely different group among patients presenting to intensive care units or neurological services worldwide. Arriving at a final diagnosis is not an easy task for treating physicians. It is very crucial to consider early use of first-line immunotherapy modalities, save those children's lives and improve outcomes...
2016: Neurology Research International
https://www.readbyqxmd.com/read/27200189/bmi-homa-ir-and-fasting-blood-glucose-are-significant-predictors-of-peripheral-nerve-dysfunction-in-adult-overweight-and-obese-nondiabetic-nepalese-individuals-a-study-from-central-nepal
#19
Lekhjung Thapa, P V S Rana
Objective. Nondiabetic obese individuals have subclinical involvement of peripheral nerves. We report the factors predicting peripheral nerve function in overweight and obese nondiabetic Nepalese individuals. Methodology. In this cross-sectional study, we included 50 adult overweight and obese nondiabetic volunteers without features of peripheral neuropathy and 50 healthy volunteers to determine the normative nerve conduction data. In cases of abnormal function, the study population was classified on the basis of the number of nerves involved, namely, "<2" or "≥2...
2016: Neurology Research International
https://www.readbyqxmd.com/read/26770824/the-role-of-the-craniocervical-junction-in-craniospinal-hydrodynamics-and-neurodegenerative-conditions
#20
REVIEW
Michael F Flanagan
The craniocervical junction (CCJ) is a potential choke point for craniospinal hydrodynamics and may play a causative or contributory role in the pathogenesis and progression of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, MS, and ALS, as well as many other neurological conditions including hydrocephalus, idiopathic intracranial hypertension, migraines, seizures, silent-strokes, affective disorders, schizophrenia, and psychosis. The purpose of this paper is to provide an overview of the critical role of the CCJ in craniospinal hydrodynamics and to stimulate further research that may lead to new approaches for the prevention and treatment of the above neurodegenerative and neurological conditions...
2015: Neurology Research International
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