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Journals Clinical Medicine Insights. Ar...

Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders

https://read.qxmd.com/read/38292917/exploring-talarozole-as-a-novel-therapeutic-approach-for-osteoarthritis-insights-from-experimental-studies
#1
JOURNAL ARTICLE
Laraib Iqbal, Ushna Zameer, Maheen Iqbal Malick
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by the slow degeneration of joint components that primarily affects the elderly. There is currently no cure for OA; thus, treatment focuses on symptom reduction. This article investigates the potential of talarozole, a retinoic acid metabolism-blocking agent (RAMBA), as a new treatment for hand OA. Talarozole showed promising results by inhibiting retinoic acid degradation and increasing its levels in the body. Six hours after destabilization of the medial meniscus, talarozole significantly reduced inflammation in mice's cartilage...
2024: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/38115857/evaluation-of-depression-and-anxiety-in-rheumatoid-arthritis-patients-during-covid-19-pandemic
#2
JOURNAL ARTICLE
Dina M Abd El-Khalik, Mohamed Eltohamy
BACKGROUND: Rheumatoid arthritis (RA) disease activity, associated comorbidities, and therapy-related side effects impair the physical, social, and emotional dimensions of the patient's health. Presently, the ongoing COVID-19 pandemic has been associated with a broad range of psychosocial disorders in various populations. Patients with RA are especially vulnerable to such effects. OBJECTIVES: Detect the prevalence of recent COVID-19 infection among patients with RA, assess depression and anxiety in these patients and their associated factors during the COVID-19 pandemic and their potential relation to disease activity...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/38115856/surgical-repair-for-rhomboid-major-tear-a-case-report
#3
Ryogo Furuhata, Sakura Yamaguchi, Atsushi Tanji
Rhomboid tears are a rare type of tendon injury. Although rhomboid tears can present with periscapular pain and scapular dyskinesis, their clinical presentations and diagnostic procedures remain largely unknown. In addition, few reports are available on the surgical treatment of rhomboid tears. We report a rhomboid repair case for a complete rhomboid major tear diagnosed based on physical findings and magnetic resonance imaging (MRI). A 28-year-old man presented with right medial scapular pain that appeared after carrying a heavy box...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/38076224/patient-reported-outcome-measures-for-patients-with-upper-extremity-arthritis-overview-of-systematic-reviews
#4
REVIEW
Armaghan Dabbagh, Christina Ziebart, Rochelle Furtado, Eleni C Boutsikari, Joy C MacDermid
BACKGROUND: Arthritis leads to disabilities impacting patients' physical and mental health. OBJECTIVE: To synthesize the evidence on measurement properties of the patient-reported outcome measures (PROMs) for people with upper extremity arthritis. DESIGN: Overview of systematic reviews (SRs). METHODS: We performed an electronic search of 6 databases to retrieve SRs looking at any measurement property related to PROMs for people with upper extremity arthritis...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/37701625/revealing-the-effect-of-spinopelvic-alignment-on-hip-disorders
#5
JOURNAL ARTICLE
Zafer Soydan, Emru Bayramoglu, Okyar Altas, Cengiz Şen
BACKGROUND: Hip osteoarthritis (HOA) is a growing burden and one of the leading causes of hip pain. The relationship between the HOA and the alignment of the spinopelvic region has been intensively studied, however the issue remains controversial. Spinopelvic imbalance, HOA, and dysplasia were investigated in relation to sagittal spinopelvic parameters in this study. METHODS: We collected computerized tomography (CT) topograms of the pelvis or abdomen from 380 patients...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/37641791/adult-onset-still-s-disease-in-an-elderly-patient-presenting-as-aseptic-meningitis-a-case-report
#6
Ujjwol Risal, Krishna Dhungana, Mrikchhya Ghimire
Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disease of unknown origin characterized mainly by fever, arthritis, and a rash. Aseptic meningitis is a rare complication of AOSD and is seen most commonly in young adults. Here, we report a case of AOSD in a 78-year female with fever and altered sensorium with lymphocyte predominant pleocytosis in the cerebrospinal fluid who was initially managed as tubercular meningitis. Adult-onset Still's disease was diagnosed as there was no response to antitubercular drugs even after 3 months and based on persistent fever, inflammatory arthritis, rash, and highly raised inflammatory markers...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/37533960/spondyloarthropathies-that-mimic-ankylosing-spondylitis-a-narrative-review
#7
REVIEW
Mina Tanios, Bradley Brickman, Jordan Norris, Sreeram Ravi, Emre Eren, Cade McGarvey, David J Morris, Hossein Elgafy
Ankylosing spondylitis is the most common type of seronegative inflammatory spondyloarthropathy often presenting with low back or neck pain, stiffness, kyphosis and fractures that are initially missed on presentation; however, there are other spondyloarthropathies that may present similarly making it a challenge to establish the correct diagnosis. Here, we will highlight the similarities and unique features of the epidemiology, pathophysiology, presentation, radiographic findings, and management of seronegative inflammatory and metabolic spondyloarthropathies as they affect the axial skeleton and mimic ankylosing spondylitis...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/37434995/relationship-between-serum-vitamin-d-level-and-disease-severity-in-rheumatoid-arthritis
#8
JOURNAL ARTICLE
Farhang Soltani Bajestani, Nasim Khajavian, Davoud Salarbashi, Mojtaba Kafili, Fatemeh Ashori, Jafar Hajavi
BACKGROUND AND OBJECTIVE: Rheumatoid arthritis is an autoimmune disease that causes joint pain and reduces daily activities. The aim of this study was to evaluate the serum of vitamin D and its relationship with the severity of the disease in patients with rheumatoid arthritis referred to Allameh Hehlool hospital in Gonabad. DESIGN AND METHODS: This cross-sectional-analytical study was performed on 92 patients referred to the rheumatology clinic of Allameh Behlool Gonabad Hospital in 2021...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/37200981/hughes-stovin-syndrome-an-experience-of-management-of-3-cases-from-a-tertiary-health-care-centre
#9
JOURNAL ARTICLE
Girija Sachdev, Sandeep Yadav, Canchi Balakrishnan, Rishabh Nanavati
Three young males with Hugh-Stovin's syndrome presented with cough, haemoptysis, fever, raised inflammatory markers, and pulmonary artery aneurysm. Only one had recurrent oral ulcers suggestive of Behcet's disease, and none were HLA B51 positive. All responded well to immunosuppression but eventually needed either an endovascular procedure or surgery.
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/37152614/sarcoidosis-mimicking-a-malignant-metastatic-disease
#10
Georges El Hasbani, Nagi El Saghir, Hicham Moukaddam, Lama Farhat, Nina Shabb, Imad Uthman
Sarcoidosis can have pulmonary and extrapulmonary clinical manifestations depending on the organ of involvement. Because multiple organs are involved by the disease, sarcoid can mimic metastatic diseases. Whenever clinical and radiological clues of metastasis are present, differentials other than cancer should not be missed. Herein, we present a case of a middle aged gentleman who presented to the oncology clinic for 1-month history of low back pain associated with a dry cough along with radiological findings of metastatic disease involving the lungs, liver, lymph nodes, axial spine, and adrenal gland...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/37122586/disordered-eating-and-body-image-concerns-in-young-adult-women-with-scoliosis
#11
JOURNAL ARTICLE
Christine A Limbers, Amy Baskin, L Adelyn Cohen
BACKGROUND: Researchers have called for more investigation into disordered eating behaviors in females with scoliosis. OBJECTIVE: The objective of the current study was to assess the associations between body image concerns, disease-specific indicators of scoliosis (ie, age of diagnosis, having undergone bracing treatment, being told by a physician your scoliosis required surgery, having a spinal fusion), quality of life, and disordered eating in a sample of young adult women diagnosed with idiopathic scoliosis during adolescence...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/37021087/an-unforeseen-outcome-of-covid-19-the-triggering-of-adult-onset-still-s-disease
#12
Hasan Alzuhaily, Seba Mohamad, Lama Alsalloum, Safaa Al-Sayed
BACKGROUND: Adult-onset Still's disease (AOSD) is a rare auto-inflammatory disorder with unknown etiology by which an infectious trigger is usually responsible for the onset of the disease. It is diagnosed by exclusion when certain clinical, biochemical, and radiological criteria are met after excluding all other potential causes. Besides, SARS‑CoV‑2 infection is increasingly being reported to have autoimmune complications. In the literature, 3 AOSD cases have been reported to be triggered by SARS‑CoV‑2 infection and here we report the fourth...
2023: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/36090594/sapho-syndrome-presenting-with-atlo-epistrophic-synovitis-and-left-vocal-cord-paresis-a-challenging-diagnosis
#13
Beatrice Maranini, Giovanni Ciancio, Rosa Rinaldi, Massimo Borrelli, Maura Pugliatti, Marcello Govoni
SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare syndrome mainly characterized by cutaneous and osteoarticular manifestations. The most typical osteoarticular manifestations are localized to the anterior chest wall and include a usually noninfectious osteitis, hyperostosis, and synovitis of the sternoclavicular joints. However, clinical presentation of SAPHO syndrome can be quite heterogeneous. Several clinical and radiological features are shared with other well-defined pathological entities, and clinical signs and symptoms often occur at different timepoints...
2022: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/36032389/radiologically-guided-versus-blinded-intra-articular-injection-in-patients-with-hip-osteoarthritis-a-retrospective-comparative-study
#14
JOURNAL ARTICLE
Ahmet Aksoy, Anil Gulcu, Mehmet Mert Tuna, Ahmet Aslan
Objectives: The aim of this study was to present the clinical results of patients with Kellgren-Lawrence (KL) stage 2-4 hip osteoarthritis who were administered intra-articular corticosteroid (CS) or hyaluronic acid (HA), with or without fluoroscopy. Methods: This retrospective comparative study was conducted in the clinics where the authors worked between 2010 and 2018. Patients with stage 2-4 hip osteoarthritis according to KL criteria were included in the study...
2022: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/35645586/the-impact-of-metabolic-syndrome-on-quality-of-life-among-individuals-with-knee-osteoarthritis-living-in-egypt
#15
JOURNAL ARTICLE
Sara F Samaan, Sara I Taha
Background: Several studies have linked metabolic syndrome (MetS) to osteoarthritis (OA), but they have not looked into how MetS can affect the health-related quality of life (HRQOL) of OA individuals. Objectives: We aimed to assess the association of MetS and its components, including obesity, hypertension, hyperglycemia, and dyslipidemia, with HRQOL among Egyptians with knee OA. Methods: This cross-sectional study comprised 116 adult Egyptian participants with knee OA...
2022: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/35645585/representation-rate-and-management-of-gout-for-patients-discharged-from-emergency-departments-in-illawarra-shoalhaven-local-health-district
#16
JOURNAL ARTICLE
Aravinthan Loganathan, Arupam Raman, Natalia Berlinski, John Riordan
Introduction: The estimated prevalence of gout in Western societies is 2.7% to 6.7%. In Australia, there have been increasing rates of hospitalisations for gout flares. Urate-lowering therapy (ULT) is effective in reducing urate burden, which can prevent gout flares and destructive arthropathy. This study assessed the representation rate of patients presenting to the Emergency Department (ED) with crystal arthropathy and the utilisation of ULT in the community for patients with a pre-existing history of gout...
2022: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/35547099/a-retrospective-observational-cohort-study-of-periprosthetic-hip-infection-treated-by-one-stage-method-including-cases-with-bone-graft-reconstruction
#17
JOURNAL ARTICLE
Ricardo Issler Unfried, Luciana Maria Fontanari Krause, Helen Minussi Cezimbra, Liliane Souto Pacheco, João Alberto Larangeira, Tiango Aguiar Ribeiro
PURPOSE: Prosthetic joint infection (PJI) is a devastating complication that can affect hip arthroplasty. Its treatment is extremely difficult, and issues regarding the optimal treatment remain unanswered. This study intended to show the effectiveness of the one-stage treatment of PJI. MATERIALS AND METHODS: A retrospective observational cohort study performed from July 2014- August 2018. All patients with suspected PJI were included. Major and minor criteria developed by the International Consensus on Periprosthetic Joint Infection (ICPJI) was used to define infection...
2022: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/35481333/can-complete-blood-count-picture-tell-us-more-about-the-activity-of-rheumatological-diseases
#18
JOURNAL ARTICLE
Sara I Taha, Sara F Samaan, Rehab Ali Ibrahim, Nouran M Moustafa, Eman M El-Sehsah, Mariam K Youssef
Background: In clinical practice, distinguishing disease activity in patients with rheumatological illnesses is challenging. Objectives: We aimed to investigate clinical associations of hemogram-derived indices, namely: red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) with disease activity in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS)...
2022: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/35360183/ingredients-of-a-natural-oral-nutritional-supplement-and-their-role-in-the-treatment-of-osteoarthritis
#19
REVIEW
Krish Tejas Bharat, Navdeep Singh Manhas, James Gutcho, Joshua Lin, Sumon Bhattacharyya, Robertus Kounang
Osteoarthritis is a prevalent degenerative disease affecting a large portion of the world's aging population. Currently, nonsteroidal anti-inflammatory drugs and acetaminophen are first-line medications for treating osteoarthritis patients' pain. However, several studies have noted that while these medications control pain they do not halt progressive degeneration and tend to have an unfavorable side-effect profile with prolonged use. Recently, due to their more favorable side-effect profiles, herbal alternatives for controlling osteoarthritis symptoms and for alleviating the progression of the disease are being increasingly studied...
2022: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
https://read.qxmd.com/read/35342315/effect-of-prophylactic-dose-of-trimethoprim-sulfamethoxazole-on-serum-creatinine-in-japanese-patients-with-connective-tissue-diseases
#20
JOURNAL ARTICLE
Rui Kawato, Ryo Rokutanda, Masato Okada, Masakazu Matsushita, Ken Yamaji, Naoto Tamura
Objectives: At normal doses of trimethoprim-sulfamethoxazole (TMP/SMX), trimethoprim inhibits tubular creatinine secretion, leading to a rapid but reversible increase in serum creatinine (SCr). Although patients with connective tissue diseases are often in the state of immunosuppression and TMP/SMX is an important prophylactic drug, clinicians often have to stop or reduce the dosage due to concerns regarding its effect on renal function. This study aimed to evaluate the effect of a prophylactic dose of TMP/SMX on SCr in Japanese patients with connective tissue diseases, the extent of SCr level elevation and the independent risk factors for creatinine elevation...
2022: Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders
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