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Hepatitis Research and Treatment

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https://www.readbyqxmd.com/read/27446609/combinations-of-sirnas-against-la-autoantigen-with-ns5b-or-hvap-a-have-additive-effect-on-inhibition-of-hcv-replication
#1
Anirban Mandal, Krishna Kumar Ganta, Binay Chaubey
Hepatitis C virus is major cause of chronic liver diseases such as chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Presently available direct-acting antiviral drugs have improved success rate; however, high cost limits their utilization, especially in developing countries like India. In the present study, we evaluated anti-HCV potential of several siRNAs targeted against the HCV RNA-dependent RNA polymerase NS5B and cellular factors, La autoantigen, PSMA7, and human VAMP-associated protein to intercept different steps of viral life cycle...
2016: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/27195149/two-year-follow-up-analysis-of-telaprevir-based-antiviral-triple-therapy-for-hcv-recurrence-in-genotype-1-infected-liver-graft-recipients-as-a-first-step-towards-modern-hcv-therapy
#2
Fritz Klein, Ruth Neuhaus, Dennis Eurich, Jörg Hofmann, Sandra Bayraktar, Johann Pratschke, Marcus Bahra
Objective. The introduction of protease inhibitors telaprevir and boceprevir in 2011 had extended the antiviral treatment options especially in genotype 1 infected hepatitis C relapsers and nonresponders to interferon/ribavirin therapy. The aim of this study was to analyze the long-term treatment efficiency of telaprevir-based triple therapy for patients with hepatitis C reinfection after orthotopic liver transplantation. Patients and Methods. We included 12 patients with histologically confirmed graft fibrosis due to hepatitis C reinfection...
2016: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/26942007/a-novel-structurally-stable-multiepitope-protein-for-detection-of-hcv
#3
Alexsandro S Galdino, José C Santos, Marilen Q Souza, Yanna K M Nóbrega, Mary-Ann E Xavier, Maria S S Felipe, Sonia M Freitas, Fernando A G Torres
Hepatitis C virus (HCV) has emerged as the major pathogen of liver diseases in recent years leading to worldwide blood-transmitted chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Accurate diagnosis for differentiation of hepatitis C from other viruses is thus of pivotal importance for proper treatment. In this work we developed a recombinant multiepitope protein (rMEHCV) for hepatitis C diagnostic purposes based on conserved and immunodominant epitopes from core, NS3, NS4A, NS4B, and NS5 regions of the virus polyprotein of genotypes 1a, 1b, and 3a, the most prevalent genotypes in South America (especially in Brazil)...
2016: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/26904281/seroprevalence-and-predictors-of-hepatitis-b-virus-infection-among-pregnant-women-attending-routine-antenatal-care-in-arba-minch-hospital-south-ethiopia
#4
Tsegaye Yohanes, Zerihun Zerdo, Nega Chufamo
Hepatitis B virus (HBV) is a serious cause of liver disease affecting millions of people throughout the world. When HBV is acquired during pregnancy, prenatal transmission can occur to the fetus. Therefore, this study is aimed at estimating seroprevalence and associated factors of HBV infection among pregnant women attending Antenatal Clinic (ANC) of Arba Minch Hospital, Southern Ethiopia. A facility based cross-sectional study was conducted on 232 pregnant women visiting ANC from February to April, 2015. Data regarding sociodemographic and associated factors were gathered using questionnaire...
2016: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/26885388/atherosclerosis-as-extrahepatic-manifestation-of-chronic-infection-with-hepatitis-c-virus
#5
REVIEW
Theodoros Voulgaris, Vassilios A Sevastianos
Chronic hepatitis C virus infection is associated with significant morbidity and mortality, as a result of progression towards advanced natural course stages including cirrhosis and hepatocellular carcinoma. On the other hand, the SVR following successful therapy is generally associated with resolution of liver disease in patients without cirrhosis. Patients with cirrhosis remain at risk of life-threatening complications despite the fact that hepatic fibrosis may regress and the risk of complications such as hepatic failure and portal hypertension is reduced...
2016: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/26199756/prevalence-of-hepatitis-e-virus-among-adults-in-south-west-of-iran
#6
Fatemeh Farshadpour, Reza Taherkhani, Manoochehr Makvandi
Background. Knowledge regarding prevalence of HEV in general population can be an indicator of the public health and hygiene. Therefore, this study was conducted to evaluate the prevalence of HEV among adults in South-West of Iran. Methods. Blood samples were taken from 510 participants, 206 (40.4%) males and 304 (59.6%) females from February to July 2014. Detection of anti-HEV IgG and IgM antibodies was carried out by ELISA test. Results. The overall anti-HEV IgG and IgM prevalence rates were 46.1% and 1.4%, respectively...
2015: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25685549/knowledge-of-hepatitis-b-virus-infection-immunization-with-hepatitis-b-vaccine-risk-perception-and-challenges-to-control-hepatitis-among-hospital-workers-in-a-nigerian-tertiary-hospital
#7
Olusegun Adekanle, Dennis A Ndububa, Samuel Anu Olowookere, Oluwasegun Ijarotimi, Kayode Thaddeus Ijadunola
Background. Studies had reported high rate of hepatitis B infection among hospital workers with low participation in vaccination programmes, especially those whose work exposes them to the risk of HBV infection. The study assessed knowledge of hepatitis B virus infection, risk perception, vaccination history, and challenges to control hepatitis among health workers. Methods. A descriptive cross-sectional study. Consenting health care workers completed a self-administered questionnaire that assessed respondents' general knowledge of HBV, vaccination history and HBsAg status, risk perception, and challenges to control hepatitis...
2015: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25692036/interleukin-16-gene-polymorphisms-are-considerable-host-genetic-factors-for-patients-susceptibility-to-chronic-hepatitis-b-infection
#8
Sara Romani, Seyed Masoud Hosseini, Seyed Reza Mohebbi, Shabnam Kazemian, Shaghayegh Derakhshani, Mahsa Khanyaghma, Pedram Azimzadeh, Afsaneh Sharifian, Mohammad Reza Zali
Host genetic background is known as an important factor in patients' susceptibility to infectious diseases such as viral hepatitis. The aim of this study was to determine the effect of genetic polymorphisms of interleukin-16 (IL-16) cytokine on susceptibility of hepatitis B virus (HBV) infected patients to develop chronic HBV infection. Genotyping was conducted using PCR followed by enzymatic digestion and RFLP (restriction fragment length polymorphism) analysis. We genotyped three single nucleotide polymorphisms (SNPs) in the Il-16 gene (rs11556218 T>G, rs4778889 T>C, and rs4072111 C>T) to test for relationship between variation at these loci and patients' susceptibility to chronic HBV infection...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25478218/hepatitis-b-awareness-among-medical-students-and-their-vaccination-status-at-syrian-private-university
#9
Nazir Ibrahim, Amr Idris
Background. Hepatitis B virus (HBV) is a potentially life-threating infection and a well-recognized occupational hazard for health-care workers including medical students. Methods. A cross-sectional study was conducted at Syrian Private University (SPU), Faculty of Medicine, to assess the knowledge and awareness about hepatitis B, the status of hepatitis B vaccination, and the reasons for not getting vaccinated among the first- and the fifth-year medical students. Results. The present study demonstrates surprising results and raises issues about the high number of medical students that are not vaccinated or not sure about their vaccination status, which puts them at a higher risk of being infected in the future...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25349730/portraying-persons-who-inject-drugs-recently-infected-with-hepatitis-c-accessing-antiviral-treatment-a-cluster-analysis
#10
Jean-Marie Bamvita, Elise Roy, Geng Zang, Didier Jutras-Aswad, Andreea Adelina Artenie, Annie Levesque, Julie Bruneau
Objectives. To empirically determine a categorization of people who inject drug (PWIDs) recently infected with hepatitis C virus (HCV), in order to identify profiles most likely associated with early HCV treatment uptake. Methods. The study population was composed of HIV-negative PWIDs with a documented recent HCV infection. Eligibility criteria included being 18 years old or over, and having injected drugs in the previous 6 months preceding the estimated date of HCV exposure. Participant classification was carried out using a TwoStep cluster analysis...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25349729/high-dose-of-lamivudine-and-resistance-in-patients-with-chronic-hepatitis-b
#11
Hamid Ullah Wani, Saad Al Kaabi, Manik Sharma, Rajvir Singh, Anil John, Moutaz Derbala, Muneera J Al-Mohannadi
Background. Lamivudine is the most affordable drug used for chronic hepatitis B and has a high safety profile. With the daily dose of 100 mg there is progressive appearance of resistance to lamivudine therapy. In our study we used 150 mg of lamivudine daily as a standard dose which warrants further exploration for the efficacy of the drug. Aims of the Study. To assess the efficacy of lamivudine 150 mg daily on resistance in patients with chronic hepatitis B. Methods. This retrospective study consists of 53 patients with chronic hepatitis B treated with 150 mg of lamivudine daily...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25328696/prediction-of-sustained-virological-response-to-telaprevir-based-triple-therapy-using-viral-response-within-2-weeks
#12
Hideyuki Tamai, Ryo Shimizu, Naoki Shingaki, Yoshiyuki Mori, Shuya Maeshima, Junya Nuta, Yoshimasa Maeda, Kosaku Moribata, Yosuke Muraki, Hisanobu Deguchi, Izumi Inoue, Takao Maekita, Mikitaka Iguchi, Jun Kato, Masao Ichinose
The aim of the present study was to predict sustained virological response (SVR) to telaprevir with pegylated interferon (PEG-IFN) and ribavirin using viral response within 2 weeks after therapy initiation. Thirty-six patients with genotype 1 hepatitis C virus (HCV) and high viral load were treated by telaprevir-based triple therapy. SVR was achieved in 72% (26/36) of patients. Significant differences between the SVR group and non-SVR group were noted regarding response to prior PEG-IFN plus ribavirin, interleukin (IL)28B polymorphism, amino acid substitution at core 70, cirrhosis, hyaluronic acid level, and HCV-RNA reduction within 2 weeks...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25295185/serum-inter-alpha-trypsin-inhibitor-heavy-chain-4-itih4-in-children-with-chronic-hepatitis-c-relation-to-liver-fibrosis-and-viremia
#13
Mostafa M Sira, Behairy E Behairy, Azza M Abd-Elaziz, Sameh A Abd Elnaby, Ehab E Eltahan
Liver fibrosis and viremia are determinant factors for the treatment policy and its outcome in chronic hepatitis C virus (HCV) infection. We aimed to investigate serum level of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) and its relation to liver fibrosis and viremia in children with chronic HCV. ITIH4 was measured by ELISA in 33 treatment-naive children with proved chronic HCV and compared according to different clinical, laboratory and histopathological parameters. Liver histopathological changes were assessed using Ishak score and compared with aspartate transaminase-to-platelet ratio (APRI) and FIB-4 indices as simple noninvasive markers of fibrosis...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25161770/seroepidemiology-of-hepatitis-b-and-c-viruses-in-the-general-population-of-burkina-faso
#14
Issoufou Tao, Tegwindé R Compaoré, Birama Diarra, Florencia Djigma, Theodora M Zohoncon, Maléki Assih, Djeneba Ouermi, Virginio Pietra, Simplice D Karou, Jacques Simpore
Objectives. In Burkina Faso, few studies reported the prevalence of HBV and HCV in the general population. This study aimed to evaluate the prevalence of hepatitis B and C viruses in the general population and to determine the most affected groups in relation to the risk factors associated with the infection. Method. A voluntary testing opened to anyone interested was held at Saint Camille Medical Centre in Ouagadougou. Rapid tests were carried out on 995 persons who voluntarily answered a range of questions before the venous blood sampling...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25136456/spectrum-of-histomorphologic-findings-in-liver-in-patients-with-sle-a-review
#15
REVIEW
Shrruti Grover, Archana Rastogi, Jyotsna Singh, Apurba Rajbongshi, Chhagan Bihari
Collagen vascular diseases (CVDs) like systemic lupus erythematosus (SLE), rheumatoid arthritis, Sjogren syndrome (SS), and scleroderma are immunologically mediated disorders that typically have multisystem involvement. Although clinically significant liver involvement is rare, liver enzyme abnormalities are common in these patients. The reported prevalence of hepatic involvement in SLE, histopathologic findings, and its significance is very variable in the existing literature. It is important to be familiar with the causes of hepatic involvement in SLE along with histomorphological features which aid in distinguishing hepatitis of SLE from other hepatic causes as they would alter the patient management and disease course...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/25093120/prevalence-of-hepatitis-c-virus-genotypes-in-district-bannu-khyber-pakhtunkhwa-pakistan
#16
Shamim Saleha, Anwar Kamal, Farman Ullah, Nasar Khan, Asif Mahmood, Sanaullah Khan
Determination of an individual's hepatitis C virus (HCV) genotypes prior to antiviral therapy has become increasingly important for the clinical management and prognosis of HCV infection. Therefore, this study was conducted to investigate the prevalence of HCV genotypes in HCV infected patients of district Bannu in Khyber Pakhtunkhwa region of Pakistan. Serum samples of 117 seropositive patients were screened for HCV-RNA by using reverse transcriptase-nested polymerase chain reaction (RT-nested PCR) and then PCR positive samples were subjected to HCV genotyping...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/24971174/mhc-class-i-presented-t-cell-epitopes-as-potential-antigens-for-therapeutic-vaccine-against-hbv-chronic-infection
#17
Joseph D Comber, Aykan Karabudak, Vivekananda Shetty, James S Testa, Xiaofang Huang, Ramila Philip
Approximately 370 million people worldwide are chronically infected with hepatitis B virus (HBV). Despite the success of the prophylactic HBV vaccine, no therapeutic vaccine or other immunotherapy modality is available for treatment of chronically infected individuals. Clearance of HBV depends on robust, sustained CD8(+) T activity; however, the limited numbers of therapeutic vaccines tested have not induced such a response. Most of these vaccines have relied on peptide prediction algorithms to identify MHC-I epitopes or characterization of T cell responses during acute infection...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/24891947/histological-and-clinical-characteristics-of-patients-with-chronic-hepatitis-c-and-persistently-normal-alanine-aminotransferase-levels
#18
Bakht Roshan, Grace Guzman
Patients with chronic hepatitis C virus (HCV) infection and persistently normal alanine aminotransferase (PNALT) are generally described to have mild liver disease. The aim of this study was to compare clinical and histological features in HCV-infected patients with PNALT and elevated ALT. Patients presenting to the University of Illinois Medical Center, Chicago, who had biopsy proven HCV, an ALT measurement at the time of liver biopsy, at least one additional ALT measurement over the next 12 months, and liver biopsy slides available for review were identified...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/24860664/prevalence-and-seroincidence-of-hepatitis-b-and-hepatitis-c-infection-in-high-risk-people-who-inject-drugs-in-china-and-thailand
#19
J Brooks Jackson, Liu Wei, Fu Liping, Apinun Aramrattana, David D Celentano, Louise Walshe, Yi Xing, Paul Richardson, Ma Jun, Geetha Beauchamp, Deborah Donnell, Yuhua Ruan, Liying Ma, David Metzger, Yiming Shao
We determined the prevalence and incidence of HBV and HCV infection in people who inject drugs (PWIDs) at high risk for HIV in China and Thailand and determined the association of HBV and HCV incidence with urine opiate test results and with short-term versus long-term buprenorphine-naloxone (B-N) treatment use in a randomized clinical trial (HPTN 058). 13.8% of 1049 PWIDs in China and 13.9% of 201 PWIDs in Thailand were HBsAg positive at baseline. Among HBsAg negative participants, the HBsAg incidence rate was 2...
2014: Hepatitis Research and Treatment
https://www.readbyqxmd.com/read/24800066/transplacental-transfer-of-hepatitis-b-neutralizing-antibody-during-pregnancy-in-an-animal-model-implications-for-newborn-and-maternal-health
#20
Li Ma, Malgorzata G Norton, Iftekhar Mahmood, Zhong Zhao, Lilin Zhong, Pei Zhang, Evi B Struble
Despite the success of postexposure prophylaxis (PEP) of the newborn in preventing mother-to-child transmission of hepatitis B virus), in non-US clinical trials, administering hepatitis B immune globulin (HBIG) to mothers at the end of pregnancy (in addition to passive-active PEP of the newborn) only partially improved outcomes. That is, a significant percentage of newborns became infected during their first year of life. We used a relevant animal model for human IgG transplacental transfer to study dose, time and subclass dependence of HBV neutralizing antibody (nAb) maternal, and fetal levels at the end of pregnancy...
2014: Hepatitis Research and Treatment
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