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Analytical Cellular Pathology (Amsterdam)

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https://www.readbyqxmd.com/read/28702312/aloesin-suppresses-cell-growth-and-metastasis-in-ovarian-cancer-skov3-cells-through-the-inhibition-of-the-mapk-signaling-pathway
#1
Li-Qian Zhang, Rong-Wei Lv, Xiang-Dong Qu, Xian-Jun Chen, Hong-Sheng Lu, Ying Wang
Aloesin is an active constituent of the herb aloe vera and plays a crucial role in anti-inflammatory activity, ultraviolet protection, and antibacterium. We investigated the role and possible mechanisms of aloesin in the cell growth and metastasis of ovarian cancer. It was found that aloesin inhibited cell viability and cell clonality in a dose-dependent manner. It arrests the cell cycle at the S-phase and induced apoptosis in SKOV3 cells. In an in vivo experiment, it was observed that aloesin inhibited tumor growth...
2017: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/28458992/effects-of-acute-toluene-toxicity-on-different-regions-of-rabbit-brain
#2
Mehmet Demır, Mustafa Cicek, Nadire Eser, Atila Yoldaş, Turgay Sısman
The acute phase effects of toluene on the brain have been investigated in this study using rabbit brain via histopathological, immunohistochemical, and biochemical methods. A total of 20 male rabbits were used as control and experimental groups. Moreover, nerve growth factor (NGF), tumor necrosis factor-alpha (TNF-alpha), dopamine (DA), and glial fibrillary acidic protein (GFAP) tests were performed in order to designate the severity of the biochemical damage. In the biochemical evaluation of the prefrontal cortex, hippocampus, hypothalamus, substantia nigra, and entorhinal cortex, the TNF-alpha levels in the brain were found to be significantly higher than in the control group...
2017: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/28331793/texture-analysis-of-abnormal-cell-images-for-predicting-the-continuum-of-colorectal-cancer
#3
Ahmad Chaddad, Camel Tanougast
Abnormal cell (ABC) is a markedly heterogeneous tissue area and can be categorized into three main types: benign hyperplasia (BH), carcinoma (Ca), and intraepithelial neoplasia (IN) or precursor cancerous lesion. In this study, the goal is to determine and characterize the continuum of colorectal cancer by using a 3D-texture approach. ABC was segmented in preprocessing step using an active contour segmentation technique. Cell types were analyzed based on textural features extracted from the gray level cooccurrence matrices (GLCMs)...
2017: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/28265532/corrigendum-to-a-simple-method-to-assess-in-vivo-proliferation-in-lung-vasculature-with-edu-the-case-of-mmc-induced-pvod-in-rat
#4
Fabrice Antigny, Benoît Ranchoux, Valérie Nadeau, Edmund Lau, Sébastien Bonnet, Frédéric Perros
[This corrects the article DOI: 10.1155/2015/326385.].
2017: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/28194324/cell-therapies-in-cardiomyopathy-current-status-of-clinical-trials
#5
REVIEW
Ming Hao, Richard Wang, Wen Wang
Because the human heart has limited potential for regeneration, the loss of cardiomyocytes during cardiac myopathy and ischaemic injury can result in heart failure and death. Stem cell therapy has emerged as a promising strategy for the treatment of dead myocardium, directly or indirectly, and seems to offer functional benefits to patients. The ideal candidate donor cell for myocardial reconstitution is a stem-like cell that can be easily obtained, has a robust proliferation capacity and a low risk of tumour formation and immune rejection, differentiates into functionally normal cardiomyocytes, and is suitable for minimally invasive clinical transplantation...
2017: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/28168162/long-noncoding-rna-mir4697hg-promotes-cell-growth-and-metastasis-in-human-ovarian-cancer
#6
Li-Qian Zhang, Su-Qing Yang, Ying Wang, Qiao Fang, Xian-Jun Chen, Hong-Sheng Lu, Ling-Ping Zhao
Ovarian cancer is one of the three most common gynecological malignant tumors worldwide. The prognosis of patients suffering from this malignancy remains poor because of limited therapeutic strategies. Herein, we investigated the role of a long noncoding RNA named MIR4697 host gene (MIR4697HG) in the cell growth and metastasis of ovarian cancer. Results showed that the transcriptional level of MIR4697HG in cancerous tissues increased twofold compared with that in adjacent noncancerous tissues. MIR4697HG was differentially expressed in ovarian cancer cell lines, with the highest levels in OVCAR3 and SKOV3 cells...
2017: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/28116228/pecam-1-leu125val-rs688-polymorphism-and-diabetic-nephropathy-in-caucasians-with-type-2-diabetes-mellitus
#7
Matej Završnik, Stojan Kariž, Jana Makuc, Maja Šeruga, Ines Cilenšek, Daniel Petrovič
Objectives. Platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a key role in the transendothelial migration of circulating leukocytes during inflammation and in the maintenance of vascular endothelial integrity. We hypothesized that genetic variation in PECAM-1 gene could be associated with diabetic nephropathy (DN) and with the level of soluble PECAM-1 in Caucasians with type 2 diabetes mellitus (T2DM). Design and Methods. We analyzed the rs688 single nucleotide polymorphism of PECAM-1 gene C373G (Leu125Val) at exon 3, which encodes the first extracellular Ig-like domain that mediates the homophilic binding of PECAM-1, in 276 T2DM subjects with documented DN (cases) and 375 T2DM subjects without DN (controls), using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/28078200/correlation-of-serum-cystatin-c-with-glomerular-filtration-rate-in-patients-receiving-platinum-based-chemotherapy
#8
Ernesta Cavalcanti, Vittoria Barchiesi, Dionigio Cerasuolo, Flaviano Di Paola, Monica Cantile, Sabrina Chiara Cecere, Sandro Pignata, Alessandro Morabito, Raffaele Costanzo, Massimo Di Maio, Francesco Perrone
Objectives. Serum cystatin C seems to be an accurate marker of glomerular filtration rate (GFR) compared to serum creatinine. The aim of this work was to explore the possibility of using serum cystatin C instead of serum creatinine to early predict renal failure in cancer patients who received platinum based chemotherapy. Design and Methods. Serum creatinine, serum cystatin C concentrations, and GFR were determined simultaneously in 52 cancer patients received carboplatin-based or cisplatin-based chemotherapy...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/28050335/in-vitro-evaluation-of-the-antimicrobial-ability-and-cytotoxicity-on-two-melanoma-cell-lines-of-a-benzylamide-derivative-of-maslinic-acid
#9
Ioana Zinuca Pavel, Corina Danciu, Camelia Oprean, Cristina Adriana Dehelean, Delia Muntean, René Csuk, Danina Mirela Muntean
Maslinic acid is a pentacyclic triterpene extracted from olives that has been systematically reported to exert several therapeutic effects, such as antitumoral, antidiabetic, antioxidant, anti-inflammatory, antiparasitic, and antiviral properties. Recently, new derivatives of maslinic acid have been obtained and expanded the spectrum of biological activities and improved the existing ones. The present study was meant to perform the in vitro assessment of the (i) cytotoxic effects of a benzylamide derivative of maslinic acid ("EM2") (benzyl (2α, 3β) 2,3-diacetoxy-olean-12-en-28-amide) on B164A5 murine melanoma and A375 human malignant melanoma cell lines and the (ii) antimicrobial activity of the compound on several bacterial strains, respectively...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27995049/annexin-a3-knockdown-suppresses-lung-adenocarcinoma
#10
Ying-Fu Liu, Qing-Qing Liu, Yue-Hua Zhang, Jing-Hua Qiu
Our previous study identified an elevated abundance of annexin A3 (Anxa3) as a novel prognostic biomarker of lung adenocarcinoma (LADC) through quantitative proteomics analysis. However, the biological functions of Anxa3 in LADC are not fully clear. In this study, in vitro and in vivo assays were performed to investigate the effects of Anxa3 downregulation on the growth, migration, invasion, metastasis, and signaling pathway activation of LADC cells. After Anxa3 downregulation, the growth of A549 and LTEP-a2 LADC cells was slowed and they showed decreased migration and invasion in vitro...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27965916/in-vivo-flow-cytometry-of-circulating-tumor-associated-exosomes
#11
Jacqueline Nolan, Mustafa Sarimollaoglu, Dmitry A Nedosekin, Azemat Jamshidi-Parsian, Ekaterina I Galanzha, Rajshekhar A Kore, Robert J Griffin, Vladimir P Zharov
Circulating tumor cells (CTCs) demonstrated the potential as prognostic markers of metastatic development. However, the incurable metastasis can already be developed at the time of initial diagnosis with the existing CTC assays. Alternatively, tumor-associated particles (CTPs) including exosomes can be a more valuable prognostic marker because they can be released from the primary tumor long before CTCs and in larger amount. However, little progress has been made in high sensitivity detection of CTPs, especially in vivo...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27882290/mast-cell-interaction-with-neutrophils-in-human-gastric-carcinomas-ultrastructural-observations
#12
Antonio Ieni, Valeria Barresi, Giovanni Branca, Rosario Alberto Caruso, Giovanni Tuccari
Aim. The role of mast cells in cell-cell immune interactions has received increasing attention, although their functional interaction with neutrophils still remains to be clarified in tumors. The aim of the present study was to investigate the association between mast cells and neutrophils in a series of gastric carcinomas (GC). Patients and Methods. 52 surgically resected GC specimens were routinely processed for both light and electron microscopy. Only cases showing both mast cells and neutrophils in the tumor stroma were considered in the analysis...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27843757/comparison-between-manual-and-automated-methods-for-ki-67-immunoexpression-quantification-in-ameloblastomas
#13
COMPARATIVE STUDY
Rogelio González-González, Nelly Molina-Frechero, Ramón G Carreón-Burciaga, Sandra López-Verdín, Carlos Robles-Bonilla, Vanesa Pereira-Prado, Ronell Bologna-Molina
Ameloblastoma is a common and unpredictable odontogenic tumor with high relapse rates. Several studies assessing the proliferative capacity of these neoplasms have been published, mainly using the protein Ki-67. Cell counts must be completed to determine the cell proliferation rate. Multiple methods have been developed for this purpose. The most widely used method is the labeling index, which has undergone changes over time to better facilitate cell counting. Here, we compared manual cell counting methods with automated cell counting (ImmunoRatio) to determine the relative effectiveness of these methods...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27822448/intraperitoneal-fat-through-grp78-a-risk-factor-for-endometrial-cancer
#14
Răzvan Ciortea, Costin Berceanu, Andrei Mihai Măluţan, Radu Mocan, Cristian Iuhas, Carmen Elena Bucuri, Maria Patricia Rada, Dan Mihu
Introduction. The identification of biological markers that indicate an increased risk for the development or recurrence of endometrial cancer (EC) in obese women might be useful for decreasing EC mortality and morbidity. Glucose-regulated protein 78 (GRP78) is a major protein of the endoplasmic reticulum expressed in all normal cells. Overexpression of GRP78 has been reported to be a tumoral biomarker. Increased detection of GRP78 is positively correlated with the tumoral stage and prognosis. This study aimed to identify a correlation between intraperitoneal fat, plasma GRP78 levels, and EC...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27812483/vegf-936-c-t-genetic-polymorphism-in-patients-with-cervical-dysplasia
#15
Ioana Cristina Rotar, Diana Elena Dumitras, Radu Anghel Popp, Felicia Maria Petrisor, Paul Cotutiu, Florin Stamatian, Daniel Muresan
Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27807511/tumor-associated-macrophages-in-kidney-cancer
#16
REVIEW
Olga V Kovaleva, Daria V Samoilova, Maria S Shitova, Alexei Gratchev
Tumor associated macrophages (TAMs) are an important element of tumor stroma. They originate from blood monocytes attracted by chemokines and cytokines produced by tumor cells and, being instructed by tumor microenvironment, develop into potent tumor-supporting cell population. TAMs were demonstrated to directly stimulate tumor cell proliferation and to promote angiogenesis. Further TAMs provide for efficient immune escape by producing immunosuppressive cytokines and facilitate tumor dissemination by producing extracellular matrix remodeling enzymes...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27747147/image-montaging-for-creating-a-virtual-pathology-slide-an-innovative-and-economical-tool-to-obtain-a-whole-slide-image
#17
Spoorthi Ravi Banavar, Prashanthi Chippagiri, Rohit Pandurangappa, Saileela Annavajjula, Premalatha Bidadi Rajashekaraiah
Background. Microscopes are omnipresent throughout the field of biological research. With microscopes one can see in detail what is going on at the cellular level in tissues. Though it is a ubiquitous tool, the limitation is that with high magnification there is a small field of view. It is often advantageous to see an entire sample at high magnification. Over the years technological advancements in optics have helped to provide solutions to this limitation of microscopes by creating the so-called dedicated "slide scanners" which can provide a "whole slide digital image...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27699143/photoacoustic-flow-cytometry-for-single-sickle-cell-detection-in-vitro-and-in-vivo
#18
Chengzhong Cai, Dmitry A Nedosekin, Yulian A Menyaev, Mustafa Sarimollaoglu, Mikhail A Proskurnin, Vladimir P Zharov
Control of sickle cell disease (SCD) stage and treatment efficiency are still time-consuming which makes well-timed prevention of SCD crisis difficult. We show here that in vivo photoacoustic (PA) flow cytometry (PAFC) has a potential for real-time monitoring of circulating sickled cells in mouse model. In vivo data were verified by in vitro PAFC and photothermal (PT) and PA spectral imaging of sickle red blood cells (sRBCs) expressing SCD-associated hemoglobin (HbS) compared to normal red blood cells (nRBCs)...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27660743/phenotypic-and-cytogenetic-characterization-of-mesenchymal-stromal-cells-in-de-novo-myelodysplastic-syndromes
#19
A J I S Rathnayake, H W W Goonasekera, V H W Dissanayake
Bone marrow (BM) mesenchymal stem/stromal cells (MSCs) are vital in hematopoiesis. Whether BM-MSCs alter their characteristics in Myelodysplastic Syndromes (MDS) is still controversial. We characterized MSCs of de novo MDS patients in Sri Lanka who have not been reported previously in the literature. We also analyzed MSCs derived from different MDS subtypes. MSCs were culture-expanded, characterized by flow cytometry, and induced towards osteogenic and adipogenic differentiation. Growth properties were determined using growth curves and population doubling times...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/27660742/predictive-and-prognostic-value-of-sprr-in-patients-with-primary-epithelial-ovarian-cancer
#20
Katrin Kreienbring, Annika Franz, Rolf Richter, Duska Dragun, Harald Heidecke, Ralf Dechend, Dominik N Muller, Jalid Sehouli, Elena I Braicu
Aim. The purpose of the present study was to analyze the predictive and prognostic role of soluble (pro)renin receptor (sPRR) as a biomarker for clinicopathological outcome in patients with primary epithelial ovarian cancer (EOC). As part of the renin-angiotensin system (RAS) whose activity is known to increase in ovarian cancer patients, the relation of sPRR and ovarian cancer should be further investigated. Patients and Methods. In this study 197 patients with primary EOC in our institution from 2000 to 2011 were included...
2016: Analytical Cellular Pathology (Amsterdam)
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