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Heart International

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https://www.readbyqxmd.com/read/27924216/atrial-fibrillation-management-in-older-heart-failure-patients-a-complex-clinical-problem
#1
REVIEW
Giovanni Pulignano, Donatella Del Sindaco, Maria Denitza Tinti, Stefano Tolone, Giovanni Minardi, Antonio Lax, Massimo Uguccioni
BACKGROUND: Atrial fibrillation (AF) and heart failure (HF), two problems of growing prevalence as a consequence of the ageing population, are associated with high morbidity, mortality, and healthcare costs. AF and HF also share common risk factors and pathophysiologic processes such as hypertension, diabetes mellitus, ischemic heart disease, and valvular heart disease often occur together. Although elderly patients with both HF and AF are affected by worse symptoms and poorer prognosis, there is a paucity of data on appropriate management of these patients...
January 2016: Heart International
https://www.readbyqxmd.com/read/27924215/influence-diagram-of-physiological-and-environmental-factors-affecting-heart-rate-variability-an-extended-literature-overview
#2
REVIEW
Julien Fatisson, Victor Oswald, François Lalonde
Heart rate variability (HRV) corresponds to the adaptation of the heart to any stimulus. In fact, among the pathologies affecting HRV the most, there are the cardiovascular diseases and depressive disorders, which are associated with high medical cost in Western societies. Consequently, HRV is now widely used as an index of health. In order to better understand how this adaptation takes place, it is necessary to examine which factors directly influence HRV, whether they have a physiological or environmental origin...
January 2016: Heart International
https://www.readbyqxmd.com/read/27924214/seasonal-variation-of-daily-physical-activity-in-individuals-with-heart-failure
#3
Michael J Shoemaker, Sarah E Roper, Tonya N Calkins
BACKGROUND: Previous studies indicate that seasonal variation affects daily physical activity (PA), but none have investigated this relationship in individuals with heart failure (HF) who also have implanted cardioverter defibrillators and cardiac resynchronization therapy (ICD/CRT) devices. The purpose of the present study was to determine if seasonal variation in temperature affects daily PA in patients with HF and ICD/CRTs. PATIENTS AND METHODS: Secondary analysis of data from 16 subjects with HF and Medtronic® ICD/CRT devices enrolled in a randomized trial investigating interventions to improve daily PA...
January 2016: Heart International
https://www.readbyqxmd.com/read/27924213/drug-eluting-stents-appear-superior-to-bare-metal-stents-for-vein-graft-pci-in-vessels-up-to-a-stent-diameter-of-4-mm
#4
Oliver P Guttmann, Daniel A Jones, Kassem A Safwan, Sean Gallagher, Krishnaraj S Rathod, Steve Hamshere, Elliot J Smith, Ajay K Jain, Anthony Mathur, Andrew Wragg, Charles J Knight, Roshan Weerackody
BACKGROUND: Research trials have shown improved short-term outcome with drug-eluting stents (DES) over bare metal stents (BMS) in saphenous vein graft (SVG) percutaneous coronary intervention (PCI), primarily by reducing target vessel revascularization (TVR) for in-stent restenosis. We compared the outcomes in patients undergoing SVG stent implantation treated with DES or BMS. In exploratory analyses we investigated the influence of stent generation and diameter. METHODS: Data were obtained from a prospective database of 657 patients who underwent PCI for SVG lesions between 2003 and 2011...
January 2016: Heart International
https://www.readbyqxmd.com/read/27924212/combined-administration-of-the-gpvi-fc-fusion-protein-revacept-with-low-dose-thrombolysis-in-the-treatment-of-stroke
#5
Andreas Reimann, Zhongmin Li, Silvia Goebel, Julia Fassbender, Hans-Peter Holthoff, Meinrad Gawaz, Götz Münch, Martin Ungerer
BACKGROUND: Thrombolytic therapy with recombinant tissue plasminogen activator (rtPA) remains the only approved medication for acute ischemic stroke, but incurs significant bleeding risks. Therefore, approaches to combine lower doses of thrombolytic therapy with other effective drugs aim at improving efficacy and reducing bleeding rates. We examined the safety and therapeutic effects of various dosings of rtPA, either alone or combined with glycoprotein VI-Fc fusion protein (GPVI-Fc, Revacept) on experimental stroke in mice...
January 2016: Heart International
https://www.readbyqxmd.com/read/27924211/circulating-mir-126-and-mir-499-reflect-progression-of-cardiovascular-disease-correlations-with-uric-acid-and-ejection-fraction
#6
Masoud Khanaghaei, Fereshtah Tourkianvalashani, Seyedhossein Hekmatimoghaddam, Nasrin Ghasemi, Mahdi Rahaie, Vahid Khorramshahi, Akhtar Sheikhpour, Zahra Heydari, Fatemeh Pourrajab
BACKGROUND: The aim of this study was to assess plasma levels of endothelium- and heart-associated microRNAs (miRNAs) miR-126 and miR-499, respectively, using quantitative reverse transcriptase polymerase chain reaction. METHODS: A two-step analysis was conducted on 75 patients undergoing off-pomp coronary artery bypass graft (CABG) surgery. Five biomarkers of inflammation and cardiac injury were assessed in addition to the above-mentioned miRNAs. RESULTS: Plasma concentrations of miRNAs were found to be significantly correlated with plasma levels of cardiac troponin I (cTnI) (miR-499, r 0...
January 2016: Heart International
https://www.readbyqxmd.com/read/27672435/differences-in-coronary-artery-blood-velocities-in-the-setting-of-normal-coronary-angiography-and-normal-stress-echocardiography
#7
Dawod Sharif, Amal Sharif-Rasslan, Camilia Shahla, Amin Khalil, Uri Rosenschein
BACKGROUND: Normal left anterior descending (LAD) coronary artery as determined by coronary angiography is considered not only to reflect normal angiography but also to correlate with normal anatomy and function. However, subjects who undergo coronary angiography may differ from those who do not need to have invasive evaluation even if their functional noninvasive studies like dobutamine stress echocardiography (DSE) were normal. AIM: LAD velocities in subjects with normal angiography and those with normal DSE are equal...
January 2015: Heart International
https://www.readbyqxmd.com/read/27672434/aspiration-thrombectomy-in-a-case-of-acute-myocardial-infarction-due-to-coronary-emboli-in-a-patient-with-peripartum-cardiomyopathy-and-mural-thrombus
#8
Abdulrahman Abdulbaki, Cyrus Kocherla, Kalgi Modi
Acute coronary syndrome (ACS) due to embolic phenomenon in the setting of peripartum cardiomyopathy (PPCM) and left ventricular mural thrombus is a rare occurrence. There have been two known cases described in medical literature. We present a unique case in which catheter-based aspiration thrombectomy was used to successfully treat a patient with ACS due to coronary emboli in the setting of PPCMand left ventricular mural thrombus. We believe this to be the first report of the use of aspiration thrombectomy in such a clinical case...
January 2015: Heart International
https://www.readbyqxmd.com/read/27672433/effectiveness-of-the-cardiopain-initiative-in-reducing-inappropriate-nsaid-prescriptions-in-pain-therapy-among-high-cardiovascular-risk-patients-an-informative-italian-survey
#9
Valentina Orlando, Enrica Menditto, Francesca Guerriero, Raffaele Rotunno
AIMS: Non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors (COXIBs) may be associated with increased cardiovascular (CV) risk and mortality in CV patients. After the release of Note 66 by Agenzia Italiana del Farmaco (AIFA) to reduce inappropriate prescribing of NSAIDs and COXIBs, the CARDIOPAIN initiative was started in Italy to include such recommendations into the hospital discharge letter of patients with high CV risk. We evaluated the effect of the CARDIOPAIN initiative on the prescription of analgesic drugs by general practitioners (GPs)...
January 2015: Heart International
https://www.readbyqxmd.com/read/27672432/yield-of-contemporary-clinical-strategies-to-detect-patients-with-obstructive-coronary-artery-disease
#10
Pedro Rio, Ruben Ramos, Tiago Pereira-da-Silva, Carlos Barbosa, Duarte Cacela, António Fiarresga, Lídia de Sousa, Ana Abreu, Lino Patrício, Luís Bernardes, Rui Cruz Ferreira
PURPOSE: Noninvasive ischemia testing (NIST) is recommended for most patients suspected to have stable coronary artery disease (CAD) before invasive coronary angiography (ICA). We sought to assess the diagnostic predictive ability of NIST over clinical risk profiling in a contemporary sample of patients undergoing the currently recommended diagnostic triage strategy. METHODS: From 2006 to 2011, 2,600 consecutive patients without known CAD undergoing elective ICA in a single tertiary-care center were retrospectively identified and the prevalence of obstructive CAD determined...
January 2015: Heart International
https://www.readbyqxmd.com/read/27672431/short-term-adjusted-outcomes-for-heart-failure
#11
Gabriele Messina, Silvia Forni, Francesca Collini, Antonello Galdo, Valeria Di Fabrizio, Nicola Nante
PURPOSE: Heart failure (HF) is recognized as a major problem in industrialized countries. Short-term adjusted outcomes are indicators of quality for care process during/after hospitalization. Our aim is to evaluate, for patients with principal diagnosis of HF, in-hospital mortality and 30-day readmissions for all-causes using two different risk adjustment (RA) tools. METHODS AND RESULTS: We used data from the hospital discharge abstract (HD) of a retrospective cohort of patients (2002-2007) admitted in Tuscan hospitals, Italy...
January 2015: Heart International
https://www.readbyqxmd.com/read/27004102/use-of-a-cni-holidays-strategy-in-acute-renal-dysfunction-late-after-heart-transplant-report-of-two-cases
#12
Pau Alonso, Ignacio Sanchez-Lazaro, Luis Almenar, Luis Martinez-Dolz, Ana Andres, Antonio Salvador, Anastasio Montero
BACKGROUND: Acute renal dysfunction (ARD) may appear in heart transplant (HTx) patients both in the early postoperative period and during follow-up, even after several years. CD25 is a subunit of the interleukin-2 receptor which is found exclusively on activated CD4 T lymphocytes. CD25 is crucial for clonal expansion of anti-allograft host lymphocytes that mediate in acute rejection. There are experiences supporting the use of Anti-CD25 monoclonal antibodies (MAb) immediately after HTx in patients with ARD as a bridge to renal function recovery, allowing the temporary suspension of treatment with CNI...
July 2014: Heart International
https://www.readbyqxmd.com/read/27004101/ranolazine-preserves-and-improves-left-ventricular-ejection-fraction-and-autonomic-measures-when-added-to-guideline-driven-therapy-in-chronic-heart-failure
#13
Gary L Murray, Joseph Colombo
BACKGROUND: Ranolazine (RAN) reduces cardiac sodium channel 1.5's late sodium current in congestive heart failure (CHF), reducing myocardial calcium overload, potentially improving left ventricular (LV) function. RAN blocks neuronal sodium channel 1.7, potentially altering parasympathetic and sympathetic (P&S) activity. The effects of RAN on LV ejection fraction (LVEF) and P&S function in CHF were studied. METHODS: Matched CHF patients were given open-label RAN (1000 mg po-bid) added to guideline-driven therapy (RANCHF, 41 systolic, 13 diastolic) or no adjuvant therapy (control, NORANCHF, 43 systolic, 12 diastolic)...
July 2014: Heart International
https://www.readbyqxmd.com/read/27004100/ranolazine-improves-autonomic-balance-in-heart-failure-when-added-to-guideline-driven-therapy
#14
Gary L Murray, Joseph Colombo
BACKGROUND: The effect of ranolazine (RAN) on cardiac autonomic balance in congestive heart failure (CHF) was studied. METHODS: Fifty-four CHF patients were randomized to (1) open-label RAN (RANCHF) added to usual therapy vs. (2) usual therapy (NORANCHF). Parasympathetic and sympathetic (P&S) measurements were taken at baseline and at 12 months. RESULTS: A total of 16/27 (59%) patients in both groups had initially abnormal P&S measures, including high sympathovagal balance (SB), cardiovascular autonomic neuropathy (CAN) or both...
July 2014: Heart International
https://www.readbyqxmd.com/read/27004099/heart-valve-surgery-euroscore-vs-euroscore-ii-vs-society-of-thoracic-surgeons-score
#15
Muhammad Sharoz Rabbani, Irfan Qadir, Yasir Ahmed, Marrium Gul, Hasanat Sharif
BACKGROUND: This is a validation study comparing the European System for Cardiac Operative Risk Evaluation (EuroSCORE) II with the previous additive (AES) and logistic EuroSCORE (LES) and the Society of Thoracic Surgeons' (STS) risk prediction algorithm, for patients undergoing valve replacement with or without bypass in Pakistan. PATIENTS AND METHODS: Clinical data of 576 patients undergoing valve replacement surgery between 2006 and 2013 were retrospectively collected and individual expected risks of death were calculated by all four risk prediction algorithms...
July 2014: Heart International
https://www.readbyqxmd.com/read/27004098/cardiac-autonomic-testing-and-treating-heart-disease-a-clinical-perspective
#16
REVIEW
Nicholas L DePace, Joy P Mears, Michael Yayac, Joseph Colombo
BACKGROUND: Coronary heart disease (CHD) is a major health concern, affecting nearly half the middle-age population and responsible for nearly one-third of all deaths. Clinicians have several major responsibilities beyond diagnosing CHD, such as risk stratification of patients for major adverse cardiac events (MACE) and treating risks, as well as the patient. This second of a two-part review series discusses treating risk factors, including autonomic dysfunction, and expected outcomes...
July 2014: Heart International
https://www.readbyqxmd.com/read/27004097/cardiac-autonomic-testing-and-diagnosing-heart-disease-a-clinical-perspective
#17
REVIEW
Nicholas L DePace, Joy P Mears, Michael Yayac, Joseph Colombo
BACKGROUND: Coronary heart disease (CHD) is a major health concern, affecting nearly half the middle-age population and responsible for nearly one-third of all deaths. Clinicians have responsibilities beyond diagnosing CHD, including risk stratification of patients for major adverse cardiac events (MACE), modifying the risks and treating the patient. In this first of a two-part review, identifying risk factors is reviewed, including more potential benefit from autonomic testing. METHODS: Traditional and non-traditional, and modifiable and non-modifiable risk factors for MACE where compared, including newer risk factors, such as inflammation, carotid intimal thickening, ankle-brachial index, CT calcium scoring, and autonomic function testing, specifically independent measurement of parasympathetic and sympathetic (P&S) activity...
July 2014: Heart International
https://www.readbyqxmd.com/read/27004096/marked-prolongation-of-qrs-duration-after-initiation-of-dronedarone-therapy
#18
Conrad Genz, Hans D Esperer, Alexander Schmeisser, Ruediger C Braun-Dullaeus, Samir M Said
Dronedarone is a relatively new antiarrhythmic drug and is held to be less proarrhythmic than comparable compounds, although its proarrhythmia potential in humans has not been sufficiently evaluated. We describe a so far unreported dronedarone effect, namely a significant alteration of both the morphology and the duration of the QRS complex on the electro cardiogram in a 41-year old patient with symptomatic paroxysmal atrial fibrillation.
January 2014: Heart International
https://www.readbyqxmd.com/read/27004095/an-unusual-cause-of-ventricular-tachycardia-port-a-cath-fracture-and-embolization-into-the-pulmonary-artery
#19
Anthony W A Wassef, Malek Kass, Gurpreet Parmar, Amir Ravandi
We describe the case of a patient with a previously placed Port-A-Cath who was admitted to hospital for new onset of non-flushing catheter and palpitations with ventricular tachycardia. A chest X-ray and a linogram showed a Port-A-Cath fracture and distal embolization into the right ventricle resulting in ventricular tachycardia. The catheter was removed percutaneously using a Goose Neck snare with no complications and resolution of the ventricular tachycardia. The removed segment demonstrated thrombus. Prompt removal of the embolized catheter fragments should be undertaken given the subtle nature of the embolization and the potential complications...
January 2014: Heart International
https://www.readbyqxmd.com/read/27004094/the-double-helix-angiography-of-right-coronary-arteries-false-lumen-stenting-of-a-type-f-right-coronary-artery-spiral-dissection-with-late-recanalization-of-the-true-lumen-and-occlusion-of-the-stented-false-lumen
#20
Anthony W Wassef, Iain Kirkpatrick, Kunal Minhas, Amrit Malik, Malek Kass, Farrukh Hussain
Guide catheter induced dissection of coronary arteries is an uncommon, but serious complication of coronary angioplasty. Treatment can include emergent coronary artery bypass grafting to the affected vessel or percutaneous intervention including wiring the true lumen and exclusion stenting of the dissection flap to prevent further propagation. Detailed descriptions have been published of techniques of intentional passage of guide wires into the false lumen and reentry into the true lumen with chronic total occlusions...
January 2014: Heart International
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