IEEE Pulse

The Center for Bioengineering Innovation and Design (CBID) at Johns Hopkins University (JHU) has established a comprehensive approach to addressing global health challenges. Central to CBID's modality on global health is a strategy that integrates education, research, and collaboration. Through its graduate program, CBID trains the next generation of health care innovators to address the specific needs of low- and middle-income countries (LMICs). Graduate student teams at CBID begin their year with a focus on a health care thematic area associated with a target country...

The Most Advanced diagnostic technologies may be amazing, but they often do not make it to resource-limited settings, including those places where particularly dangerous pathogens are more prevalent, crowded conditions make outbreaks more likely, or medical facilities are less available.

Health Care Innovation is the creation, development, and translation of new and better solutions to health care challenges. At its core, this endeavor does not require extending the frontiers of science or the creation of new fundamental technologies. Rather, it is primarily focused on the use of existing science and established technologies in the design of new solutions to problems in health care. Successfully innovating for low- and middle-income countries (LMICs) requires a needs and stakeholder-driven approach to enable development and adoption of available, accessible, and acceptable solutions tailored to the specific need and context of care...

Throughout history, the world's biggest technological innovations have emerged from rich countries. Resource availability, economic prosperity that supports specialization in key areas of science and industry, and the concentrated centers of learning that such economies create all support this model. But history sometimes turns back on itself, and this is one of those moments.

Most of us know the restorative value of an early night, so on some level we instinctively understand that sleep is good for both the body and the mind. Now, a growing body of research is starting to show just how vital sleep is to our overall health and longevity. Some believe that laughter is no longer the best medicine-sleep is.

Cardiovascular disease may be the world's leading killer of men and women, but new technologies are in development that could help lessen its impact. Among them are a variety of innovative external and internal patches that employ flexible and stretchable materials, machine learning, and other tactics to monitor heart activity and function, and in some cases to provide on-the-spot treatment.

In 2023, Brain implants got a big boost. Neuralink, Elon Musk's startup, began recruiting for its first clinical trial for paralysis patients; Precision Neuroscience received breakthrough designation from the Food and Drug Administration (FDA), allowing it to fast-track its own trials. Meanwhile, scientific advances are revealing promising new applications for such devices, including more comprehensive restoration of speech, sight, hearing, and movement to people who have lost those abilities, as well as help for psychiatric conditions, such as eating disorders and depression...

Focused ultrasound is an early stage, noninvasive therapy with the potential to treat a range of medical conditions. Like diagnostic ultrasound, it uses sound waves above the range of human hearing. But its purpose is to interact with tissues in the body, rather than just produce images of them. In focused ultrasound, multiple, intersecting beams of high frequency sound are aimed to converge on specific targets deep within the body. There, the ultrasound energy can act in multiple ways to either modify or destroy tissue...

When the Voyager 1 spacecraft was hurtling past Neptune to points beyond, its camera swung back to snap an image of Earth, a tiny spot of light in the vast, dark expanse. That 1990 image offered a stark reminder of just how vulnerable our planet is. The U.S. National Aeronautics and Space Administration (NASA) remains focused on space exploration today, but is also providing an Earth-side role, notably in understanding climate change and how it affects human health, and in inspiring new research and products to help people cope with varying weather patterns and the threats they bring...

For over a century, scientists have known that the brain contains multiple cell types, dating back to Santiago Ramón y Cajal's earliest observations of brain tissue under a microscope. But until recently, we lacked the tools to study those cells with enough resolution to truly understand their roles.

CRISPR-Cas9, the tool for editing genes by precisely cutting DNA and letting the body's natural DNA repair processes take over, deservedly led to Nobel prizes in 2020 for its pioneers, Emmanuelle Charpentier and Jennifer Doudna. Since their breakthroughs in 2012, the technology has moved forward in leaps and bounds, and techniques to manipulate genes that were once the realm of science fiction are becoming very much science "fact."

Emergent technologies are frequently demonized due to the fear of the unknown. The doubts and alarms are more often than not sparked by their own developers, in a secret wish to become the masters of such fears, and thereby increase their control and influence upon laymen. The story is as old as the use of fire by the sorcerers guiding most ancient rituals. Now it seems to be the turn of artificial intelligence (AI), which is being continuously tainted with quasi-apocalyptic shadows, despite its remarkable potentials for supporting highly desirable societal transformations...

In The U.K., a heated debate is raging in the genetics community about a not-so-new technology and its role in public health. Cheap genetic tests to discover our ancestry have become familiar consumer products, and our genes can tell us a lot about our ancestry, so it is an appealing idea that they can tell us about our susceptibility to serious diseases. Polygenic risk scores (PRS)-generated by sequencing multiple parts of a person's DNA-are said by some to hold the key to helping people avoid everything from type 1 diabetes to cardiovascular disease and cancer...

Until relatively recently, basic biomedical research was almost exclusively conducted with male human, animal, and cell models. It was widely assumed that the research findings and medical treatments developed from these studies could be generalized to the whole population. However, there are sex differences in key biological pathways and processes that can influence a person's disease risk, experience of symptoms, and response to treatment. The lack of female representation in preclinical biomedical research has resulted in gaps in our medical knowledge, with important consequences for women's health...

"The traditional way of delivering drugs has a very low efficiency. For instance, with solid tumors, drug delivery efficiency is reported to be lower than 1% [1], which means that 99% of the drug is elsewhere in the body causing side effects instead of actually fighting the cancer. This is where micro- and nanorobots can come into play, because they can swim or otherwise move to the target location in a controllable way. This is the hope."-Tian Qiu, Ph.D., biomedical robotics developer.

In Late January 2023, the National Institute of Biomedical Imaging and Bioengineering (NIBIB) launched a new center designed to accelerate biomedical discovery and therapeutics, in part by pulling together expert, multidisciplinary teams from throughout the National Institutes of Health (NIH) to quickly respond when national or global health crises strike. The inaugural director of this Center for BME Technology Acceleration, or BETA Center, is biomedical engineer Manu Platt, Ph.D., (Figure 1) who is also taking on the role of NIBIB associate director for scientific diversity, equity, and inclusion...

The health and well-being of refugees, internally displaced persons (IDPs), and stateless communities are often at risk due to political, logistical, and security challenges associated with providing adequate and timely medical aid to the deserving groups [1]. These challenges are further exacerbated by the absence of context-appropriate technologies that can aid in diagnosis, management, and treatment of life-threatening illnesses. The health challenges faced by forcibly displaced communities are a product of unique factors ranging from conflict to climate change and are further complicated by the living conditions and the surrounding environment [2]...

The global coronavirus pandemic has demonstrated the necessity of engineering approaches, from research and development to rapid prototyping and production, in saving lives all across the world [1]. From personal protective equipment design to vaccine production and distribution, engineering has been the bedrock of an effective global response. However, despite major gains made in the last several decades, there are still millions all across the world, including the vulnerable displaced, who rarely benefit from new developments at the interface of engineering, biology, and health...

Bioprinting is an additive manufacturing process used to create architectures that mimic natural living tissues in form and function [1]. It involves the deposition of bioink, which can include a mixture of living cells, nutrients, and extracellular matrix. The bioink is then deposited onto a scaffold to generate 3-D structures that imitate natural tissues and organs. This process has already been used to generate a diverse range of products, including bioprinted human ears for transplant, and 3-D printed bioceramic and modified biopolymer bone implants that received U...

Back in 1992, when Prof. Tim Spector of King's College London set up a study to investigate the incidence of osteoporosis and other rheumatologic diseases in monozygotic (identical) twins, little did he know how much the project would expand its horizons. From a few hundred identical twins, the cohort has grown to more than 15,000 identical and nonidentical twins across the U.K., aged between 18 and 100, and a host of diseases and conditions are under the microscope (Figure 1). Now, TwinsUK has one of the most deeply characterized adult twin cohorts anywhere in the world, providing vast quantities of data for longitudinal studies of health and aging...