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Cholesterol

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https://www.readbyqxmd.com/read/27818794/in-vivo-antihypercholesterolemic-potential-of-swietenia-mahagoni-leaf-extract
#1
Naveen Yelaware Puttaswamy, Asna Urooj
The present investigation aims to evaluate antihypercholesterolemic potential of Swietenia mahagoni leaf aqueous extract (MAE) in diet-induced hypercholesterolemic rat model. In the study, Wistar albino rats (170-220 g) were segregated into 5 groups; all the groups except normal control group were given high fat diet to induce hypercholesterolemia. After induction of cholesterolemia, normal control and positive control groups were treated with saline, statin group was treated with atorvastatin, and remaining two groups received MAE in two doses (250 and 500 mg kg(-1) BW) for a treatment period of one month...
2016: Cholesterol
https://www.readbyqxmd.com/read/27213054/trends-of-prevalence-of-uncontrolled-risk-factors-for-cerebrocardiovascular-disease-southern-italy-from-1988-9-to-2008-9
#2
Vincenzo Capuano, Norman Lamaida, Ernesto Capuano, Rocco Capuano, Eduardo Capuano, Gianfranco Mazzotta
The aim of this study was to determine the trends of cardiovascular risk factor prevalence between 1988/9 and 2008/9 in the 25-74-year-old population in an area of Southern Italy. We compared three cross-sectional studies conducted in random population samples, in 1988/9, 1998/9, and 2008/9 in Salerno, Italy. The methodology of data collection (lipid profile, systolic and diastolic blood pressure, glycaemia, and smoking) and conducting tests which the population underwent during the three phases was standardized and comparable...
2016: Cholesterol
https://www.readbyqxmd.com/read/27190643/evaluation-of-antidiabetic-and-antihyperlipidemic-effects-of-peganum-harmala-seeds-in-diabetic-rats
#3
Gholamreza Komeili, Mohammad Hashemi, Mohsen Bameri-Niafar
The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200-230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and 120 mg/kg) of hydroalcoholic extract of Peganum harmala seeds for 4 weeks orally. At the end of treatment, blood samples were taken and glucose, triglycerides, total cholesterol, LDL-c, HDL-c, malondialdehyde (MDA), total antioxidant capacity (TCA), ALT, AST, GGT, bilirubin, and glycosylated hemoglobin (HbA1C) were determined...
2016: Cholesterol
https://www.readbyqxmd.com/read/26998355/cholesterol-lowering-effect-of-plant-stanol-ester-yoghurt-drinks-with-added-camelina-oil
#4
Pia Salo, Päivi Kuusisto
The aim of this study was to investigate the effects of yoghurt minidrinks containing two doses of plant stanol ester either with or without added camelina oil on the serum cholesterol levels in moderately hypercholesterolemic subjects. In this randomised, double-blind, parallel group study, 143 subjects consumed a 65 mL minidrink together with a meal daily for four weeks. The minidrink contained 1.6 or 2.0 grams of plant stanols with or without 2 grams of alpha-linolenic acid-rich camelina oil. The placebo minidrink did not contain plant stanols or camelina oil...
2016: Cholesterol
https://www.readbyqxmd.com/read/26823981/lipid-lowering-effects-of-hydroalcoholic-extract-of-anethum-graveolens-l-and-dill-tablet-in-high-cholesterol-fed-hamsters
#5
Ebrahim Abbasi Oshaghi, Iraj Khodadadi, Massoud Saidijam, Reza Yadegarazari, Nooshin Shabab, Heidar Tavilani, Mohamad Taghi Goodarzi
Objective. This study was aimed to determine the effect of Anethum graveolens extract and Anethum graveolens (dill) tablet on lipid profile, liver enzymes, and gene expression and enzymatic activity of HMG-CoA reductase in high cholesterol fed hamsters. Materials and Methods. Golden Syrian male hamsters (130 ± 10 g) were randomly divided into 6 groups (n = 6) and received daily the following: group 1 received chow + 2% cholesterol + 0.5% cholic acid (HCD), groups 2 and 3 received HCD diet plus 100 and 200 mg/kg hydroalcoholic extract of dill, respectively, and groups 4 and 5 received HCD diet plus 100 and 200 mg/kg dill tablet, respectively...
2015: Cholesterol
https://www.readbyqxmd.com/read/26788366/cholesterol-transporters-abca1-and-abcg1-gene-expression-in-peripheral-blood-mononuclear-cells-in-patients-with-metabolic-syndrome
#6
Zahra Tavoosi, Hemen Moradi-Sardareh, Massoud Saidijam, Reza Yadegarazari, Shiva Borzuei, Alireza Soltanian, Mohammad Taghi Goodarzi
ABCA1 and ABCG1 genes encode the cholesterol transporter proteins that play a key role in cholesterol and phospholipids homeostasis. This study was aimed at evaluating and comparing ABCA1 and ABCG1 genes expression in metabolic syndrome patients and healthy individuals. This case-control study was performed on 36 patients with metabolic syndrome and the same number of healthy individuals in Hamadan (west of Iran) during 2013-2014. Total RNA was extracted from mononuclear cells and purified using RNeasy Mini Kit column...
2015: Cholesterol
https://www.readbyqxmd.com/read/26634153/dysfunctional-high-density-lipoprotein-an-innovative-target-for-proteomics-and-lipidomics
#7
REVIEW
Juan Salazar, Luis Carlos Olivar, Eduardo Ramos, Mervin Chávez-Castillo, Joselyn Rojas, Valmore Bermúdez
High-Density Lipoprotein-Cholesterol (HDL-C) is regarded as an important protective factor against cardiovascular disease, with abundant evidence of an inverse relationship between its serum levels and risk of cardiovascular disease, as well as various antiatherogenic, antioxidant, and anti-inflammatory properties. Nevertheless, observations of hereditary syndromes featuring scant HDL-C concentration in absence of premature atherosclerotic disease suggest HDL-C levels may not be the best predictor of cardiovascular disease...
2015: Cholesterol
https://www.readbyqxmd.com/read/26617998/the-effect-of-elevated-triglycerides-on-the-onset-and-progression-of-coronary-artery-disease-a-retrospective-chart-review
#8
Deepu Daniel, Patrick Hardigan, Asif Jawaid, Rohit Bhandari, Mithun Daniel
Background. The American College of Cardiology and American Heart Association did not indicate a correlation between treating hypertriglyceridemia and reducing cardiovascular events. Objective. This study investigated whether patients with hypertriglyceridemia were more prone to worse outcomes during cardiac catheterization. Methods. Data collected over a one-year period analyzed lipid panels obtained at the time of cardiac catheterization. Triglyceride levels were categorized into three groups: <150 mg/dL, 150 mg/dL-300 mg/dL, and >300 mg/dL...
2015: Cholesterol
https://www.readbyqxmd.com/read/26543642/optimal-use-of-plant-stanol-ester-in-the-management-of-hypercholesterolemia
#9
REVIEW
Susanna Rosin, Ilkka Ojansivu, Aino Kopu, Malin Keto-Tokoi, Helena Gylling
Plant stanol ester is a natural compound which is used as a cholesterol-lowering ingredient in functional foods and food supplements. The safety and efficacy of plant stanol ester have been confirmed in more than 70 published clinical studies and the ingredient is a well-established and widely recommended dietary measure to reduce serum cholesterol. Daily intake of 2 g plant stanols as plant stanol ester lowers LDL-cholesterol by 10%, on average. In Europe, foods with added plant stanol ester have been on the market for 20 years, and today such products are also available in many Asian and American countries...
2015: Cholesterol
https://www.readbyqxmd.com/read/25861469/serum-cholesterol-reduction-efficacy-of-biscuits-with-added-plant-stanol-ester
#10
Wantanee Kriengsinyos, Ajima Wangtong, Surat Komindr
This study's aim was to test the low-density lipoprotein cholesterol- (LDL-c-) lowering efficacy of biscuits containing 2 g of plant stanols, which corresponded to 3.4 g of plant stanol esters. The biscuit is a new food format that can be consumed as a snack. In a double-blind, placebo-controlled parallel design study, 119 mildly to moderately hypercholesterolemic volunteers were randomized to plant stanol or control groups. Subjects were comparable in age, gender, lipid profiles, and body mass index. They consumed a control biscuit once a day for a two-week period, followed by a four-week intervention period that either had a plant stanol ester biscuit or a control...
2015: Cholesterol
https://www.readbyqxmd.com/read/25692035/nonselective-mevalonate-kinase-inhibitor-as-a-novel-class-of-antibacterial-agents
#11
Mohammad Gharehbeglou, Ghasem Arjmand, Mohammad Reza Haeri, Mohammad Khazeni
Introduction. There are a few evidences about targeting isoprenoids biosynthesis pathway in bacteria for finding new antibiotics. This study was conducted to assess antibacterial effects of vanadyl sulfate (VS), one of the mevalonate kinase inhibitors to find a new target for killing bacteria. Materials and Methods. Antibacterial effect of VS alone and in combination with glycine or EDTA was assessed on Escherichia coli and Pseudomonas aeruginosa as Gram-negative and Staphylococcus aureus and Enterococcus faecalis as Gram-positive bacteria using serial dilution method and minimum inhibitory concentrations (MICs) identified...
2015: Cholesterol
https://www.readbyqxmd.com/read/25580288/severe-extreme-hypertriglyceridemia-and-ldl-apheretic-treatment-review-of-the-literature-original-findings
#12
REVIEW
Olga Diakoumakou, Georgios Hatzigeorgiou, Nikos Gontoras, Maria Boutsikou, Vana Kolovou, Sophie Mavrogeni, Vassiliki Giannakopoulou, Genovefa D Kolovou
Hypertriglyceridemia (HTG) is a feature of numerous metabolic disorders including dyslipidemias, metabolic syndrome, and diabetes mellitus type 2 and can increase the risk of premature coronary artery disease. HTG may also be due to genetic factors (called primary HTG) and particularly the severe/extreme HTG (SEHTG), which is a usually rare genetic disorder. Even rarer are secondary cases of SEHTG caused by autoimmune disease. This review considers the causes of SEHTG, and their management including treatment with low density lipoprotein apheresis and analyzes the original findings...
2014: Cholesterol
https://www.readbyqxmd.com/read/25478215/effects-of-atorvastatin-on-resting-and-peak-exercise-blood-pressure-among-normotensive-men-and-women
#13
Amanda L Zaleski, Marianne L Mentch, Linda S Pescatello, Beth A Taylor, Jeffrey A Capizzi, Adam S Grimaldi, Priscilla M Clarkson, Stephanie A Moeckel-Cole, Stuart R Chipkin, Justin Keadle, Charles Michael White, Paul D Thompson
Statins are the most widely prescribed and effective medication for reducing low density lipoprotein cholesterol. Statins may also lower resting blood pressure (BP); however, results are inconsistent. We sought to determine if the maximum dose of atorvastatin reduces resting BP and the peak systolic BP (SBP) achieved on a graded exercise stress test (GEST) among a large sample of 419 healthy men (48%) and women (52%). Subjects (419, 44.1 ± 0.8 yr) were double-blinded and randomized to 80 mg·d(-1) of atorvastatin (n = 202) or placebo (n = 217) for 6 mo...
2014: Cholesterol
https://www.readbyqxmd.com/read/25400944/association-of-the-total-cholesterol-content-of-erythrocyte-membranes-with-the-severity-of-disease-in-stable-coronary-artery-disease
#14
Gholamreza Namazi, Morteza Pourfarzam, Sabieh Jamshidi Rad, Ahmad Movahedian Attar, Nizal Sarrafzadegan, Masoumeh Sadeghi, Parastoo Asa
Increasing evidence suggests that erythrocytes may participate in atherogenesis. We sought to investigate whether the total cholesterol content of erythrocyte membranes (CEM) is significantly different in patients with stable coronary artery disease (CAD) compared to patients with nonsignificant coronary stenosis and determine the correlation between CEM and the severity of coronary stenosis. Methods. The population included 144 patients, undergoing clinically indicated coronary angiography. The severity of coronary stenosis was scored after coronary angiography and patients were divided into two groups; the S-stenosis group (CAD patients, n = 82) had a significant stenosis indicated by coronary angiography and the second group, N-stenosis (n = 62), had nonsignificant coronary stenosis...
2014: Cholesterol
https://www.readbyqxmd.com/read/25215231/a-comprehensive-in-silico-analysis-of-the-functional-and-structural-impact-of-nonsynonymous-snps-in-the-abca1-transporter-gene
#15
Francisco R Marín-Martín, Cristina Soler-Rivas, Roberto Martín-Hernández, Arantxa Rodriguez-Casado
Disease phenotypes and defects in function can be traced to nonsynonymous single nucleotide polymorphisms (nsSNPs), which are important indicators of action sites and effective potential therapeutic approaches. Identification of deleterious nsSNPs is crucial to characterize the genetic basis of diseases, assess individual susceptibility to disease, determinate molecular and therapeutic targets, and predict clinical phenotypes. In this study using PolyPhen2 and MutPred in silico algorithms, we analyzed the genetic variations that can alter the expression and function of the ABCA1 gene that causes the allelic disorders familial hypoalphalipoproteinemia and Tangier disease...
2014: Cholesterol
https://www.readbyqxmd.com/read/25161769/effects-of-securigera-securidaca-extract-on-lipolysis-and-adipogenesis-in-diabetic-rats
#16
Ahmad Ghorbani, Reyhaneh Moradi Marjaneh, Ziba Rajaei, Mousa-Al-Reza Hadjzadeh
Diabetes mellitus is associated with dysregulation of adipose tissue metabolism and increased level of serum lipids. In our previous work we found that Securigera securidaca decreases cholesterol level in blood of diabetic rats. The present study was carried out to further investigate the effects of this plant on lipid metabolism, lipolysis, and adipogenesis, in diabetic rats. Female Wistar rats were rendered diabetic by intraperitoneal injection of streptozotocin. Retroperitoneal adipose tissue was removed from diabetic animals after seven days of streptozotocin injection...
2014: Cholesterol
https://www.readbyqxmd.com/read/24672716/the-influence-of-an-obesogenic-diet-on-oxysterol-metabolism-in-c57bl-6j-mice
#17
Joshua S Wooten, Huaizhu Wu, Joe Raya, Xiaoyuan Dai Perrard, John Gaubatz, Ron C Hoogeveen
Our current understanding of oxysterol metabolism during different disease states such as obesity and dyslipidemia is limited. Therefore, the aim of this study was to determine the effect of diet-induced obesity on the tissue distribution of various oxysterols and the mRNA expression of key enzymes involved in oxysterol metabolism. To induce obesity, male C57BL/6J mice were fed a high fat-cholesterol diet for 24 weeks. Following diet-induced obesity, plasma levels of 4 β -hydroxycholesterol, 5,6 α -epoxycholesterol, 5,6 β -epoxycholesterol, 7 α -hydroxycholesterol, 7 β -hydroxycholesterol, and 27-hydroxycholesterol were significantly (P < 0...
2014: Cholesterol
https://www.readbyqxmd.com/read/24672715/validation-of-the-friedewald-formula-in-patients-with-metabolic-syndrome
#18
José Knopfholz, Caio César Diniz Disserol, Andressa Jardim Pierin, Fernanda Letícia Schirr, Larissa Streisky, Lilian Lumi Takito, Patrícia Massucheto Ledesma, José Rocha Faria-Neto, Marcia Olandoski, Claudio Leinig Pereira da Cunha, Antonio Milton Bandeira
Currently, the Friedewald formula (FF) is the main method for evaluating low-density lipoprotein cholesterol (LDL-c). Recently, many limitations have emerged regarding its use, including patients with triglyceride levels ≥400 mg/dL, diabetes mellitus, and kidney or hepatic chronic diseases. We analyzed the use of the FF in patients with metabolic syndrome. We selected patients with known metabolic syndrome that fulfilled the National Cholesterol Education Program Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report and excluded patients with triglyceride levels ≥400 mg/dL and chronic liver and/or kidney disease...
2014: Cholesterol
https://www.readbyqxmd.com/read/24386561/short-term-effect-of-pitavastatin-treatment-on-glucose-and-lipid-metabolism-and-oxidative-stress-in-fasting-and-postprandial-state-using-a-test-meal-in-japanese-men
#19
Hirokazu Kakuda, Junji Kobayashi, Mio Nakato, Noboru Takekoshi
Introduction. The objective of this study was to clarify how pitavastatin affects glucose and lipid metabolism, renal function, and oxidative stress. Methods. Ten Japanese men (average age of 33.9 years) were orally administered 2 mg of pitavastatin for 4 weeks. Postprandial glucose, lipoprotein metabolism, and oxidative stress markers were evaluated at 0 and 4 weeks of pitavastatin treatment (2 mg once daily) with a test meal consisting of total calories: 460 kcal, carbohydrates: 56.5 g (226 kcal), protein: 18 g (72 kcal), lipids: 18 g (162 kcal), and NaCl: 1...
2013: Cholesterol
https://www.readbyqxmd.com/read/24382995/apoa2-polymorphism-in-relation-to-obesity-and-lipid-metabolism
#20
Moushira Erfan Zaki, Khalda Sayed Amr, Mohamed Abdel-Hamid
Objectives. This study aims to analysis the relationship between c.-492T>C polymorphism in APOA2 gene and the risk for obesity in a sample of Egyptian adolescents and investigates its effect on body fat distribution and lipid metabolism. Material and Methods. A descriptive, cross-sectional study was conducted on 303 adolescents. They were 196 obese and 107 nonobese, aged 16-19 years old. Variables examined included body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), systolic and diastolic blood pressure (BP), body fat percentage (BF%), abdominal visceral fat layer, and dietary intake...
2013: Cholesterol
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