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Aging and Disease

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https://www.readbyqxmd.com/read/28203485/relationship-of-circulating-cxcr4-epc-with-prognosis-of-mild-traumatic-brain-injury-patients
#1
Yunpeng Lin, Lan Lan Luo, Jian Sun, Weiwei Gao, Ye Tian, Eugene Park, Andrew Baker, Jieli Chen, Rongcai Jiang, Jianning Zhang
To investigate the changes of circulating endothelial progenitor cells (EPCs) and stromal cell-derived factor-1α (SDF-1α)/CXCR4 expression in patients with mild traumatic brain injury (TBI) and the correlation between EPC level and the prognosis of mild TBI. 72 TBI patients (57 mild TBI, 15 moderate TBI patients) and 25 healthy subjects (control) were included. The number of circulating EPCs, CD34(+), and CD133(+) cells and the percentage of CXCR4(+) cells in each cell population at 1,4,7,14,21 days after TBI were counted by flow cytometer...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203484/lw-afc-effects-on-n-glycan-profile-in-senescence-accelerated-mouse-prone-8-strain-a-mouse-model-of-alzheimer-s-disease
#2
Jianhui Wang, Xiaorui Cheng, Ju Zeng, Jiangbei Yuan, Zhongfu Wang, Wenxia Zhou, Yongxiang Zhang
Glycosylation is one of the most common eukaryotic post-translational modifications, and aberrant glycosylation has been linked to many diseases. However, glycosylation and glycome analysis is a significantly challenging task. Although several lines of evidence have indicated that protein glycosylation is defective in Alzheimer's disease (AD), only a few studies have focused on AD glycomics. The etiology of AD is unclear and there are no effective disease-modifying treatments for AD. In this study, we found that the object recognition memory, passive avoidance, and spatial learning and memory of senescence-accelerated mouse prone 8 (SAMP8) strain, an AD animal model, were deficient, and LW-AFC, which was prepared from the traditional Chinese medicine prescription Liuwei Dihuang decoction, showed beneficial effects on the deterioration of cognitive capability in SAMP8 mice...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203483/galanin-protects-from-caspase-8-12-initiated-neuronal-apoptosis-in-the-ischemic-mouse-brain-via-galr1
#3
Yun Li, Zhu Mei, Shuiqiao Liu, Tong Wang, Hui Li, Xiao-Xiao Li, Song Han, Yutao Yang, Junfa Li, Zhi-Qing David Xu
Galanin (GAL) plays key role in many pathophysiological processes, but its role in ischemic stroke remains unclear. Here, the models of 1 h middle cerebral artery occlusion (MCAO)/1-7 d reperfusion (R)-induced ischemic stroke and in vitro cell ischemia of 1 h oxygen-glucose deprivation (OGD)/24 h reoxygenation in primary cultured cortical neurons were used to explore GAL's effects and its underlying mechanisms. The results showed significant increases of GAL protein levels in the peri-infarct region (P) and infarct core (I) within 48 h R of MCAO mice (p<0...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203482/long-non-coding-rna-h19-induces-cerebral-ischemia-reperfusion-injury-via-activation-of-autophagy
#4
Jue Wang, Bin Cao, Dong Han, Miao Sun, Juan Feng
Long non-coding RNA H19 (lncRNA H19) was found to be upregulated by hypoxia, its expression and function have never been tested in cerebral ischemia and reperfusion (I/R) injury. This study intended to investigate the role of lncRNA H19 and H19 gene variation in cerebral I/R injury with focusing on its relationship with autophagy activation. Cerebral I/R was induced in rats by middle cerebral artery occlusion followed by reperfusion. SH-SY5Y cells were subjected to oxygen and glucose deprivation and reperfusion (OGD/R) to simulate I/R injury...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203481/lens-endogenous-peptide-%C3%AE-a66-80-generates-hydrogen-peroxide-and-induces-cell-apoptosis
#5
Murugesan Raju, Puttur Santhoshkumar, K Krishna Sharma
In previous studies, we reported the presence of a large number of low-molecular-weight (LMW) peptides in aged and cataract human lens tissues. Among the LMW peptides, a peptide derived from αA-crystallin, αA66-80, was found in higher concentration in aged and cataract lenses. Additional characterization of the αA66-80 peptide showed beta sheet signature, and it formed well-defined unbranched fibrils. Further experimental data showed that αA66-80 peptide binds α-crystallin, impairs its chaperone function, and attracts additional crystallin proteins to the peptide α-crystallin complex, leading to the formation of larger light scattering aggregates...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203480/a-novel-immunosuppressor-5r-5-hydroxytriptolide-alleviates-movement-disorder-and-neuroinflammation-in-a-6-ohda-hemiparkinsonian-rat-model
#6
Ruijun Su, Min Sun, Wei Wang, Jianliang Zhang, Li Zhang, Junli Zhen, Yanjing Qian, Yan Zheng, Xiaomin Wang
Parkinson's disease (PD) is one of the most common age-related neurodegenerative diseases. Promising therapies for PD still need to be explored. Immune dysfunction has been found to be involved in PD pathogenesis. Here, a novel immunosuppressor, (5R)-5-hydroxytriptolide (LLDT8), was used to treat 6-hydroxydopamine (6-OHDA)-induced hemiparkinson rats. We found that oral administration of LLDT8 significantly alleviated apomorphine-induced rotations at a dose of 125 µg/kg, and improved performance in cylinder and rotarod tests at a lower dose of 31...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203479/metformin-impairs-spatial-memory-and-visual-acuity-in-old-male-mice
#7
Nopporn Thangthaeng, Margaret Rutledge, Jessica M Wong, Philip H Vann, Michael J Forster, Nathalie Sumien
Metformin is an oral anti-diabetic used as first-line therapy for type 2 diabetes. Because benefits of metformin extend beyond diabetes to other age-related pathology, and because its effect on gene expression profiles resembles that of caloric restriction, metformin has a potential as an anti-aging intervention and may soon be assessed as an intervention to extend healthspan. However, beneficial actions of metformin in the central nervous system have not been clearly established. The current study examined the effect of chronic oral metformin treatment on motor and cognitive function when initiated in young, middle-aged, or old male mice...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203478/potential-biochemical-mechanisms-of-lung-injury-in-diabetes
#8
REVIEW
Hong Zheng, Jinzi Wu, Zhen Jin, Liang-Jun Yan
Accumulating evidence has shown that the lung is one of the target organs for microangiopathy in patients with either type 1 or type 2 diabetes mellitus (DM). Diabetes is associated with physiological and structural abnormalities in the diabetic lung concurrent with attenuated lung function. Despite intensive investigations in recent years, the pathogenic mechanisms of diabetic lung injury remain largely elusive. In this review, we summarize currently postulated mechanisms of diabetic lung injury. We mainly focus on the pathogenesis of diabetic lung injury that implicates key pathways, including oxidative stress, non-enzymatic protein glycosylation, polyol pathway, NF-κB pathway, and protein kinase c pathway...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28203477/imaging-and-quantitative-analysis-of-the-interstitial-space-in-the-caudate-nucleus-in-a-rotenone-induced-rat-model-of-parkinson-s-disease-using-tracer-based-mri
#9
Deyong Lv, Jingbo Li, Hongfu Li, Yu Fu, Wei Wang
Parkinson's disease (PD) is characterized by pathological changes within several deep structures of the brain, including the substantia nigra and caudate nucleus. However, changes in interstitial fluid (ISF) flow and the microstructure of the interstitial space (ISS) in the caudate nucleus in PD have not been reported. In this study, we used tracer-based magnetic resonance imaging (MRI) to quantitatively investigate the alterations in ISS and visualize ISF flow in the caudate nucleus in a rotenone-induced rat model of PD treated with and without madopar...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28197358/biocomplexity-and-fractality-in-the-search-of-biomarkers-of-aging-and-pathology-focus-on-mitochondrial-dna-and-alzheimer-s-disease
#10
Annamaria Zaia, Pierluigi Maponi, Giuseppina Di Stefano, Tiziana Casoli
Alzheimer's disease (AD) represents one major health concern for our growing elderly population. It accounts for increasing impairment of cognitive capacity followed by loss of executive function in late stage. AD pathogenesis is multifaceted and difficult to pinpoint, and understanding AD etiology will be critical to effectively diagnose and treat the disease. An interesting hypothesis concerning AD development postulates a cause-effect relationship between accumulation of mitochondrial DNA (mtDNA) mutations and neurodegenerative changes associated with this pathology...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28053826/sensorineural-organs-dysfunction-and-cognitive-decline-a-review-article
#11
REVIEW
Supakanya Wongrakpanich, Aisawan Petchlorlian, Andrew Rosenzweig
Vision, hearing, olfaction, and cognitive function are essential components of healthy and successful aging. Multiple studies demonstrate relationship between these conditions with cognitive function. The present article focuses on hearing loss, visual impairment, olfactory loss, and dual sensory impairments in relation to cognitive declination and neurodegenerative disorders. Sensorineural organ impairment is a predictive factor for mild cognitive impairment and neurodegenerative disorders in the elderly. We recommend early detection of sensorineural dysfunction by history, physical examination, and screening tests...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28053825/bioactive-flavonoids-and-catechols-as-hif1-and-nrf2-protein-stabilizers-implications-for-parkinson-s-disease
#12
Natalya A Smirnova, Navneet Ammal Kaidery, Dmitry M Hushpulian, Ilay I Rakhman, Andrey A Poloznikov, Vladimir I Tishkov, Saravanan S Karuppagounder, Irina N Gaisina, Anton Pekcec, Klaus Van Leyen, Sergey V Kazakov, Lichuan Yang, Bobby Thomas, Rajiv R Ratan, Irina G Gazaryan
Flavonoids are known to trigger the intrinsic genetic adaptive programs to hypoxic or oxidative stress via estrogen receptor engagement or upstream kinase activation. To reveal specific structural requirements for direct stabilization of the transcription factors responsible for triggering the antihypoxic and antioxidant programs, we studied flavones, isoflavones and catechols including dihydroxybenzoate, didox, levodopa, and nordihydroguaiaretic acid (NDGA), using novel luciferase-based reporters specific for the first step in HIF1 or Nrf2 protein stabilization...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28053824/low-normal-tsh-levels-are-associated-with-impaired-bmd-and-hip-geometry-in-the-elderly
#13
Su Jin Lee, Kyoung Min Kim, Eun Young Lee, Mi Kyung Song, Dae Ryong Kang, Hyeon Chang Kim, Yoosik Youm, Young Mi Yun, Hyun-Young Park, Chang Oh Kim, Yumie Rhee
Subclinical hyperthyroidism is known to be associated with the risk of fractures in elderly people. However, there are few studies assessing whether low normal thyroid-stimulating hormone (TSH) levels affect bone density and geometry. Here, we aimed to assess the influence of the TSH level on bone mineral density (BMD) and geometry in elderly euthyroid subjects. This was a cross-sectional cohort study. A total of 343 men and 674 women with euthyroidism were included and analyzed separately. The subjects were divided into tertiles based on the serum TSH level...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28053823/global-metabolic-profiling-of-plasma-shows-that-three-year-mild-caloric-restriction-lessens-an-age-related-increase-in-sphingomyelin-and-reduces-l-leucine-and-l-phenylalanine-in-overweight-and-obese-subjects
#14
Minjoo Kim, Sang-Hyun Lee, Jong Ho Lee
The effect of weight loss from long-term, mild-calorie diets (MCD) on plasma metabolites is unknown. This study was to examine whether MCD-induced weight reduction caused changes in the extended plasma metabolites. Overweight and obese subjects aged 40-59 years consumed a MCD (approximately 100 kcal/day deficit, n=47) or a weight-maintenance diet (control, n=47) in a randomized, controlled design with a three-year clinical intervention period and plasma samples were analyzed by using UPLC-LTQ-Orbitrap mass spectrometry...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28053822/bulbocavernosus-reflex-test-for-diagnosis-of-pudendal-nerve-injury-in-female-patients-with-diabetic-neurogenic-bladder
#15
Xiaoting Niu, Xun Wang, Huanjie Huang, Peiqi Ni, Yuanshao Lin, Bei Shao
The study was designed to investigate the clinical application and significance of the bulbocavernosus reflex (BCR) test for diagnosing diabetic neurogenic bladder (DNB) in female subjects. In this study, 68 female patients with DNB and 40 female normal controls were subjected to a nerve conduction study (NCS) of all four limbs and the BCR test. The data were analyzed and compared, and the corresponding diagnostic sensitivities were discussed. Mean BCR latency for female DNB patients was significantly prolonged, compared to that of the control group, suggesting pudendal nerve injuries in female DNB patients...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28053821/microrna-181c-exacerbates-brain-injury-in-acute-ischemic-stroke
#16
Qingfeng Ma, Haiping Zhao, Zhen Tao, Rongliang Wang, Ping Liu, Ziping Han, Shubei Ma, Yumin Luo, Jianping Jia
MicroRNA-181 (miR-181) is highly expressed in the brain, and downregulated in miRNA expression profiles of acute ischemic stroke patients. However, the roles of miR-181c in stroke are not known. The clinical relevance of miR-181c in acute stroke patients was evaluated by real-time PCR and correlation analyses. Proliferation and apoptosis of BV2 microglial cells and Neuro-2a cells cultured separately or together under oxidative stress or inflammation were assessed with the Cell Counting Kit-8 and by flow cytometry, respectively...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28053820/effects-of-different-concurrent-resistance-and-aerobic-training-frequencies-on-muscle-power-and-muscle-quality-in-trained-elderly-men-a-randomized-clinical-trial
#17
Rodrigo Ferrari, Sandra C Fuchs, Luiz Fernando Martins Kruel, Eduardo Lusa Cadore, Cristine Lima Alberton, Ronei Silveira Pinto, Régis Radaelli, Maira Schoenell, Mikel Izquierdo, Hirofumi Tanaka, Daniel Umpierre
Muscle power is a strong predictor of functional status in the elderly population and is required to perform different daily activities. To compare the effects of different weekly training frequencies on muscle power and muscle quality induced by concurrent training (resistance + aerobic) in previously trained elderly men. Twenty-four trained elderly men (65 ± 4 years), previously engaged in a regular concurrent training program, three times per week, for the previous five months, were randomly allocated to concurrent training programs in which training was performed either twice a week (2·week(-1), n = 12) or three times per week (3·week(-1), n = 12)...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28053819/thalamic-atrophy-contributes-to-low-slow-wave-sleep-in-neuromyelitis-optica-spectrum-disorder
#18
Lei Su, Yujuan Han, Rong Xue, Kristofer Wood, Fu-Dong Shi, Yaou Liu, Ying Fu
Slow wave sleep abnormality has been reported in neuromyelitis optica spectrum disorder (NMOSD), but mechanism for such abnormality is unknown. To determine the structural defects in the brain that account for the decrease of slow wave sleep in NMOSD patients. Thirty-three NMOSD patients and 18 matched healthy controls (HC) were enrolled. Polysomnography was used to monitor slow wave sleep and three-dimensional T1-weighted MRIs were obtained to assess the alterations of grey matter volume. The percentage of deep slow wave sleep decreased in 93% NMOSD patients...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28053818/association-between-serum-magnesium-levels-and-depression-in-stroke-patients
#19
Yingying Gu, Kai Zhao, Xiaoqian Luan, Zhihua Liu, Yan Cai, Qiongzhang Wang, Beilei Zhu, Jincai He
Post-stroke depression (PSD) is a common psychiatric complication of stroke that is associated with a poor outcome in stroke patients. Our aim was to assess the association between the serum magnesium levels and the presence of PSD in Chinese patients. Two hundred nine stroke patients were included in the study. Depressive symptoms were measured by the 17-Hamilton Rating Scale for Depression at 3 months after stroke. Based on the depressive symptoms, diagnoses of depression were made in line with the DSM-IV criteria for PSD...
December 2016: Aging and Disease
https://www.readbyqxmd.com/read/28053817/pretreatment-with-ginseng-fruit-saponins-affects-serotonin-expression-in-an-experimental-comorbidity-model-of-myocardial-infarction-and-depression
#20
Mei-Yan Liu, Yan-Ping Ren, Li-Jun Zhang, Jamie Y Ding
We previously demonstrated that serotonin (5-HT) and 5-HT2A receptor (5-HT2AR) levels in platelets were up- or down-regulated after myocardial infarction (MI) associated with depression. In this study, we further evaluated the effects of pretreatment with ginseng fruit saponins (GFS) on the expression of 5-HT and 5-HT2AR in MI with or without depression. Eighty Sprague-Dawley (SD) rats were treated with saline and GFS (n=40 per group). The animals were then randomly divided into four subgroups: sham, MI, depression, and MI + depression (n=10 per subgroup)...
December 2016: Aging and Disease
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