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Aging and Disease

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https://www.readbyqxmd.com/read/29896440/mammalian-sterile20-like-kinases-signalings-and-roles-in-central-nervous-system
#1
REVIEW
Sheng Chen, Yuanjian Fang, Shenbin Xu, Cesar Reis, Jianmin Zhang
Mammalian Sterile20-like (MST) kinases are located upstream in the mitogen-activated protein kinase pathway, and play an important role in cell proliferation, differentiation, renewal, polarization and migration. Generally, five MST kinases exist in mammalian signal transduction pathways, including MST1, MST2, MST3, MST4 and YSK1. The central nervous system (CNS) is a sophisticated entity that takes charge of information reception, integration and response. Recently, accumulating evidence proposes that MST kinases are critical in the development of disease in different systems involving the CNS...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896439/bdnf-polymorphism-a-review-of-its-diagnostic-and-clinical-relevance-in-neurodegenerative-disorders
#2
REVIEW
Ting Shen, Yuyi You, Chitra Joseph, Mehdi Mirzaei, Alexander Klistorner, Stuart L Graham, Vivek Gupta
Brain-derived neurotrophic factor (BDNF) has a unique role in the neuronal development, differentiation, and survival in the developing and adult nervous system. A common single-nucleotide polymorphism in the pro-region of the human BDNF gene, resulting in a valine to methionine substitution (Val66Met), has been associated with the susceptibility, incidence, and clinical features of several neurodegenerative disorders. Much research has been dedicated to evaluating the effects of polymorphism in the past decade, and functional effects of this genetic variation...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896438/effects-of-therapeutic-hypothermia-combined-with-other-neuroprotective-strategies-on-ischemic-stroke-review-of-evidence
#3
REVIEW
Zheng Zhang, Linlei Zhang, Yuchuan Ding, Zhao Han, Xunming Ji
Ischemic stroke is a major cause of death and disability globally, and its incidence is increasing. The only treatment approved by the US Food and Drug Administration for acute ischemic stroke is thrombolytic treatment with recombinant tissue plasminogen activator. As an alternative, therapeutic hypothermia has shown excellent potential in preclinical and small clinical studies, but it has largely failed in large clinical studies. This has led clinicians to explore the combination of therapeutic hypothermia with other neuroprotective strategies...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896437/the-short-term-prognostic-value-of-the-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-in-acute-ischemic-stroke
#4
Qi-Wen Deng, Shuo Li, Huan Wang, Leix Lei, Han-Qing Zhang, Zheng-Tian Gu, Fang-Lan Xing, Fu-Ling Yan
The triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) is a simple approach to predicting unfavorable outcomes in cardiovascular disease. The influence of TG/HDL-C on acute ischemic stroke remains elusive. The purpose of this study was to investigate the precise effect of TG/HDL-C on 3-month mortality after acute ischemic stroke (AIS). Patients with AIS were enrolled in the present study from 2011 to 2017. A total of 1459 participants from a single city in China were divided into retrospective training and prospective test cohorts...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896436/frailty-in-older-adults-with-cardiovascular-disease-cause-effect-or-both
#5
Emma Ef Kleipool, Emiel O Hoogendijk, Marijke C Trappenburg, M Louis Handoko, Martijn Huisman, Mike Jl Peters, Majon Muller
Cardiovascular disease (CVD) has been associated with an increased risk of frailty, but the direction of the association remains unclear. This study set out to examine the bidirectional longitudinal association between CVD and frailty over an extended period of time. Data are from 1432 older adults (aged 65-88yrs) of the Longitudinal Aging Study Amsterdam (LASA), who were followed for 17 years. At baseline and follow-up, CVD was assessed through self-report, medication use and medical records, and classified as angina pectoris, myocardial infarction, heart failure (HF), stroke, and peripheral artery disease...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896435/the-value-of-contrast-enhanced-ultrasonography-combined-with-real-time-strain-elastography-in-the-early-diagnosis-of-prostate-cancer
#6
Ying Chang, Jingchun Yang, Hua Hong, Huijuan Ma, Xin Cui, Li Chen
To evaluate the performance of a combination of real-time strain elastography (RTSE) and contrast-enhanced transrectal ultrasound (CETRUS) for prostate cancer detection. Patients with serum prostate-specific antigen (PSA) levels of ≥4.0 ng/ml were prospectively enrolled between June 2014 and December 2016. 153 prostate nodules diagnosed by conventional ultrasound were prospectively enrolled and examined by CETRUS and RTSE before a biopsy. Multivariate logistic regression models were established for CETRUS, and CETRUS combined with RTSE to diagnose prostate malignancy...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896434/splenectomy-fails-to-provide-long-term-protection-against-ischemic-stroke
#7
Yuanyuan Ran, Zongjian Liu, Shuo Huang, Jiamei Shen, Fengwu Li, Wenxiu Zhang, Chen Chen, Xiaokun Geng, Zhili Ji, Huishan Du, Xiaoming Hu
Splenectomy before or immediately after stroke provides early brain protection. This study aims to explore the effect of splenectomy on long-term neurological recovery after stroke, which is currently lacking in the field. Adult male rats were randomized into splenectomy or sham groups and then subjected to 90 min of middle cerebral artery occlusion (MCAO). Spleen was removed right upon reperfusion or 3d after MCAO. Infarct volume, neurological functions, and peripheral immune cell populations were assessed up to 28d after stroke...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896433/apx3330-promotes-neurorestorative-effects-after-stroke-in-type-one-diabetic-rats
#8
Tao Yan, Poornima Venkat, Michael Chopp, Alex Zacharek, Peng Yu, Ruizhuo Ning, Xiaoxi Qiao, Mark R Kelley, Jieli Chen
APX3330 is a selective inhibitor of APE1/Ref-1 redox activity. In this study, we investigate the therapeutic effects and underlying mechanisms of APX3330 treatment in type one diabetes mellitus (T1DM) stroke rats. Adult male Wistar rats were induced with T1DM and subjected to transient middle cerebral artery occlusion (MCAo) and treated with either PBS or APX3330 (10mg/kg, oral gavage) starting at 24h after MCAo, and daily for 14 days. Rats were sacrificed at 14 days after MCAo and, blood brain barrier (BBB) permeability, ischemic lesion volume, immunohistochemistry, cell death assay, Western blot, real time PCR, and angiogenic ELISA array were performed...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896432/progression-of-white-matter-hyperintensities-contributes-to-lacunar-infarction
#9
Xin Xu, Yuanyuan Gao, Renyuan Liu, Lai Qian, Yan Chen, Xiaoying Wang, Yun Xu
Both white matter hyperintensities (WMHs) and lacunar infarctions (LIs) are magnetic resonance imaging (MRI) markers of cerebral small vessel disease (SVD). However, the association between WMH and LI remains unclear. In this study, we asked whether WMH progression is related to LI occurrence using retrospective data. Overall, 8475 WMH patients with at least two MRI images were screened, and 187 patients were included in the final study; 76 patients had WMH with LI (WL), and 111 patients had WMH without LI (WOL)...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896431/repetitive-element-dna-methylation-is-associated-with-menopausal-age
#10
Sha Lu, Zheng Niu, Yueming Chen, Qiaofeng Tu, Yue Zhang, Wenli Chen, Wenjuan Tong, Zhifen Zhang
To investigate associations between the age of menopause and the DNA methylation levels of two repetitive elements, Alu and LINE-1, we performed plasma DNA extraction on 161 subjects and serum cell-free DNA extraction on 120 subjects. We grouped women by menopausal age as follows: ≤ 48 years (earlier menopause), ≥ 52 years (later menopause), and 48-52 years (control). The DNA methylation levels of Alu and LINE-1 were measured by MethyLight PCR. The results showed that the DNA methylation levels of both Alu and LINE-1 were inversely correlated with menopausal age in the plasma DNA cohort (r = 0...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896430/prehospital-notification-procedure-improves-stroke-outcome-by-shortening-onset-to-needle-time-in-chinese-urban-area
#11
Sheng Zhang, Jungen Zhang, Meixia Zhang, Genlong Zhong, Zhicai Chen, Longting Lin, Min Lou
Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) can improve clinical outcome in eligible patients with acute ischemic stroke (AIS). However, its efficacy is strongly time-dependent. This study was aimed to examine whether prehospital notification by emergency medical service (EMS) providers could reduce onset to needle time (ONT) and improve neurological outcome in AIS patients who received IVT. We prospectively collected the consecutive clinical and time data of AIS patients who received IVT during one year after the initiation of prehospital notification procedure (PNP)...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896429/invasion-of-peripheral-immune-cells-into-brain-parenchyma-after-cardiac-arrest-and-resuscitation
#12
Can Zhang, Nicole R Brandon, Kerryann Koper, Pei Tang, Yan Xu, Huanyu Dou
Although a direct link has long been suspected between systemic immune responses and neuronal injuries after stroke, it is unclear which immune cells play an important role. A question remains as to whether the blood brain barrier (BBB) is transiently disrupted after circulatory arrest to allow peripheral immune cells to enter brain parenchyma. Here, we developed a clinically relevant cardiac arrest and resuscitation model in mice to investigate the BBB integrity using noninvasive magnetic resonance imaging...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896428/mild-therapeutic-hypothermia-protects-the-brain-from-ischemia-reperfusion-injury-through-upregulation-of-iaspp
#13
Xiangrong Liu, Shaohong Wen, Shunying Zhao, Feng Yan, Shangfeng Zhao, Di Wu, Xunming Ji
Mild therapeutic hypothermia, a robust neuroprotectant, reduces neuronal apoptosis, but the precise mechanism is not well understood. Our previous study showed that a novel inhibitor of an apoptosis-stimulating protein of p53 (iASPP) might be involved in neuronal death after stroke. The aim of this study was to confirm the role of iASPP after stroke treated with mild therapeutic hypothermia. To address this, we mimicked ischemia/reperfusion injury in vitro by using oxygen-glucose deprivation/reperfusion (OGD/R) in primary rat neurons...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896427/evaluation-of-hyperbaric-oxygen-treatment-in-acute-traumatic-spinal-cord-injury-in-rats-using-diffusion-tensor-imaging
#14
Wenzhi Sun, Jiewen Tan, Zhuo Li, Shibao Lu, Man Li, Chao Kong, Yong Hai, Chunjin Gao, Xuehua Liu
This study aimed to evaluate the therapeutic effect of hyperbaric oxygen (HBO) on acute spinal cord injury (SCI) by measuring the in vivo diffusion tensor imaging (DTI) parameters apparent diffusion coefficient (ADC) and fractional anisotropy (FA) and observing diffusion tensor tractography (DTT) of fiber bundle morphology. The rats were randomly divided into sham-operated (SH), SCI, and SCI and hyperbaric oxygen treatment (SCI + HBO) groups (n = 6 in each group). The Basso-Bettie-Bresnahan (BBB) score was used to evaluate motor function recovery, and DTI was performed on days 3, 7, 14, and 21 after surgery...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896426/pro-and-anti-inflammatory-effects-of-high-cholesterol-diet-on-aged-brain
#15
Yali Chen, Mengmei Yin, Xuejin Cao, Gang Hu, Ming Xiao
Both hypercholesterolemia and aging are related to cognitive decline or Alzheimer's disease. However, their interactive influence on the neurodegenerative progress remains unclear. To address this issue, 6-month-old and 16-month-old female mice were fed a 3% cholesterol diet for 8 weeks, followed by hippocampus-related functional, pathological, biochemical and molecular analyses. The high cholesterol diet did not exacerbate age-dependent cognitive decline and hippocampal neuronal death, and even greatly mitigated decreases of synaptophysin and growth associated protein 43 expression in the hippocampus of aged mice...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896425/aged-mice-are-more-resistant-to-influenza-virus-infection-due-to-reduced-inflammation-and-lung-pathology
#16
Jiao Lu, Xuefeng Duan, Wenming Zhao, Jing Wang, Haoyu Wang, Kai Zhou, Min Fang
Immune responses are a double-edged sword. Effective and appropriate immune responses capable of controlling viral infection while also largely preserving tissue integrity, are critical for host survival. Too strong immune responses might result in immune pathology, while too weak immune responses might cause viral persistence. Physiologic ageing is accompanied with a decline in the normal functioning of the immune system, which is termed as "immunosenescence". We show that aged mice (16-19 months old) are more resistant to influenza A virus (IAV) infection than the young mice...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896424/association-of-apoe-genetic-polymorphism-and-type-2-diabetes-with-cognition-in-non-demented-aging-chinese-adults-a-community-based-cross-sectional-study
#17
Jie Zhen, Tong Lin, Xiaochen Huang, Huiqiang Zhang, Shengqi Dong, Yifan Wu, Linlin Song, Rong Xiao, Linhong Yuan
Apolipoprotein E (ApoE) gene polymorphism has been implicated in predisposition to diabetes and dementia in old population, but the results from the different studies were inconclusive. A cross-sectional study was carried out to explore the relationship among ApoE gene polymorphism, diabetes and cognition in non-demented aging Chinese adults. A total number of 1000 community dwellers aged 55 years and above were randomly recruited. Demographic information of the participants was collected using well designed self-administered questionnaires...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896423/anserine-carnosine-supplementation-preserves-blood-flow-in-the-prefrontal-brain-of-elderly-people-carrying-apoe-e4
#18
Qiong Ding, Kitora Tanigawa, Jun Kaneko, Mamoru Totsuka, Yoshinori Katakura, Etsuko Imabayashi, Hiroshi Matsuda, Tatsuhiro Hisatsune
In a previously reported double-blind, randomized controlled trial (RCT), we demonstrated that daily supplementation with anserine (750 mg) and carnosine (250 mg) improves brain blood flow and memory function in elderly people. Here, we conducted a sub-analysis of MRI data and test scores from the same RCT to determine whether anserine/carnosine supplementation specifically benefits elderly people carrying the APOE e4 allele, which is a risk gene for accelerated brain aging and for the onset of Alzheimer's Disease...
June 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896422/aging-health-and-r-d-for-healthy-longevity-must-be-included-into-the-who-work-program
#19
EDITORIAL
Ilia Stambler, Kunlin Jin, Stephanie Lederman, Nir Barzilai, S Jay Olshansky, Emem Omokaro, Jane Barratt, Vladimir N Anisimov, Suresh Rattan, Shaohua Yang, Michael Forster, Julie Byles
No abstract text is available yet for this article.
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29896421/age-dependent-decrease-in-adropin-is-associated-with-reduced-levels-of-endothelial-nitric-oxide-synthase-and-increased-oxidative-stress-in-the-rat-brain
#20
Changjun Yang, Kelly M DeMars, Eduardo Candelario-Jalil
Adropin is a peptide highly expressed in the brain. Emerging evidence indicates that low plasma levels of adropin are closely associated with aging and endothelial dysfunction. We hypothesized that aging reduces adropin levels in the brain, which correlates with reduced endothelial nitric oxide synthase (eNOS) and increased oxidative stress associated with age-related endothelial dysfunction. Cortical brain tissue and plasma were collected from young (10-12 weeks old) and aged (18-20 months old) male Sprague-Dawley naïve rats...
April 2018: Aging and Disease
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