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Aging and Disease

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https://www.readbyqxmd.com/read/29675290/diagnostic-and-immunosuppressive-potential-of-elevated-mir-424-levels-in-circulating-immune-cells-of-ischemic-stroke-patients
#1
Guangwen Li, Qingfeng Ma, Rongliang Wang, Zhibin Fan, Zhen Tao, Ping Liu, Haiping Zhao, Yumin Luo
Our previous study demonstrated that microRNA-424 (miR-424) protected against experimental stroke through inhibition of microglial proliferation and activation by targeting cell cycle proteins. The purpose of this study was to further explore the clinical significance of miR-424 in peripheral immune cells of patients with acute ischemic stroke (AIS). Blood samples were collected from 40 patients within 6 hours of symptom onset and 27 control subjects. MiR-424 levels in lymphocytes, neutrophils and plasma were determined by quantitative realtime-PCR...
April 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392091/chronic-remote-ischemic-conditioning-may-mimic-regular-exercise-perspective-from-clinical-studies
#2
Wenbo Zhao, Sijie Li, Changhong Ren, Ran Meng, Xunming Ji
Chronic remote ischemic conditioning (RIC), particularly long-term repeated RIC, has been applied in clinical trials with the expectation that it could play its protective roles for protracted periods. In sports medicine, chronic RIC has also been demonstrated to improve exercise performance, akin to improvements seen with regular exercise training. Therefore, chronic RIC may mimic regular exercise, and they may have similar underlying mechanisms. In this study, we explored the common underlying mechanisms of chronic RIC and physical exercise in protecting multiple organs and benefiting various populations, the advantages of chronic RIC, and the challenges for its popularization...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392090/acute-sarcopenia-secondary-to-hospitalisation-an-emerging-condition-affecting-older-adults
#3
REVIEW
Carly Welch, Zaki K Hassan-Smith, Carolyn A Greig, Janet M Lord, Thomas A Jackson
There has been increasing interest and research into sarcopenia in community-dwelling older adults since the European Working Group on Sarcopenia in Older People (EWGSOP) agreed a consensus definition in 2010. Sarcopenia has been defined as loss of muscle mass with loss of muscle function (strength or physical performance), with measurements two Standard Deviations (SDs) below the mean of a young reference population. This definition does not necessitate longitudinal measurements, or the absence of acute illness and diagnosis can be made from single measurements...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392089/a-comprehensive-review-of-non-steroidal-anti-inflammatory-drug-use-in-the-elderly
#4
REVIEW
Supakanya Wongrakpanich, Amaraporn Wongrakpanich, Katie Melhado, Janani Rangaswami
NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation; however, NSAIDs are known for multiple adverse effects, including gastrointestinal bleeding, cardiovascular side effects, and NSAID induced nephrotoxicity. As our society ages, it is crucial to have comprehensive knowledge of this class of medication in the elderly population. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, current guidelines for NSAIDs use, adverse effect profile, and drug interaction of NSAIDs and commonly used medications in the elderly...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392088/micrornas-and-presbycusis
#5
REVIEW
Weiming Hu, Junwu Wu, Wenjing Jiang, Jianguo Tang
Presbycusis (age-related hearing loss) is the most universal sensory degenerative disease in elderly people caused by the degeneration of cochlear cells. Non-coding microRNAs (miRNAs) play a fundamental role in gene regulation in almost every multicellular organism, and control the aging processes. It has been identified that various miRNAs are up- or down-regulated during mammalian aging processes in tissue-specific manners. Most miRNAs bind to specific sites on their target messenger-RNAs (mRNAs) and decrease their expression...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392087/role-of-dietary-protein-and-muscular-fitness-on-longevity-and-aging
#6
REVIEW
Barbara Strasser, Konstantinos Volaklis, Dietmar Fuchs, Martin Burtscher
Muscle atrophy is an unfortunate effect of aging and many diseases and can compromise physical function and impair vital metabolic processes. Low levels of muscular fitness together with insufficient dietary intake are major risk factors for illness and mortality from all causes. Ultimately, muscle wasting contributes significantly to weakness, disability, increased hospitalization, immobility, and loss of independence. However, the extent of muscle wasting differs greatly between individuals due to differences in the aging process per se as well as physical activity levels...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392086/alteration-of-copper-fluxes-in-brain-aging-a-longitudinal-study-in-rodent-using-64-cucl-2-pet-ct
#7
Fangyu Peng, Fang Xie, Otto Muzik
Brain aging is associated with changes of various metabolic pathways. Copper is required for brain development and function, but little is known about changes in copper metabolism during brain aging. The objective of this study was to investigate alteration of copper fluxes in the aging mouse brain with positron emission tomography/computed tomography using 64 CuCl2 as a radiotracer (64 CuCl2 -PET/CT). A longitudinal study was conducted in C57BL/6 mice (n = 5) to measure age-dependent brain and whole-body changes of 64 Cu radioactivity using PET/CT after oral administration of 64 CuCl2 as a radiotracer...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392085/causes-of-death-in-chinese-patients-with-multiple-system-atrophy
#8
LingYu Zhang, Bei Cao, Yutong Zou, Qian-Qian Wei, RuWei Ou, Wanglin Liu, Bi Zhao, Jing Yang, Ying Wu, HuiFang Shang
The objective of this study was to explore the causes of death in Chinese patients with multiple system atrophy (MSA) as well as differences in the cause of death according to sex, subtype, disease onset, and whether the disease was accompanied by nocturnal stridor. A total of 131 MSA patients were enrolled and followed up once every year until their deaths. Clinical information was collected by neurologists, and the cause of death of the MSA patients was obtained from the patients' relatives or caregivers...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392084/cardiovascular-risk-factors-are-correlated-with-low-cognitive-function-among-older-adults-across-europe-based-on-the-share-database
#9
Joana Lourenco, Antonio Serrano, Alice Santos-Silva, Marcos Gomes, Claudia Afonso, Paula Freitas, Constanca Paul, Elisio Costa
Increased life expectancy is associated with a high prevalence of chronic, non-communicable diseases including cognitive decline and dementia. The purpose of this study was to evaluate the prevalence of cognitive impairment using three cognitive abilities (verbal fluency, numeracy and perceived memory) and their association with cardiovascular risk factors in seniors across Europe. Data from participants in wave 4 of the SHARE (Survey of Health, Ageing, and Retirement in Europe) database was used. Cognitive performance in perceived memory, verbal fluency and numeracy was evaluated using simple tests and a memory complaints questionnaire...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392083/short-telomere-length-is-associated-with-aging-central-obesity-poor-sleep-and-hypertension-in-lebanese-individuals
#10
Nathalie K Zgheib, Fatima Sleiman, Lara Nasreddine, Mona Nasrallah, Nancy Nakhoul, Hussain Isma'eel, Hani Tamim
In Lebanon, data stemming from national cross-sectional surveys indicated significant increasing trends in the prevalence of cardiovascular diseases and associated behavioral and age-related risk factors. To our knowledge, no data are available on relative telomere length (RTL) as a potential biomarker for age-related diseases in a Lebanese population. The aim of this study was to evaluate whether there is an association between RTL and demographic characteristics, lifestyle habits and diseases in the Lebanese...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392082/apelin-ameliorates-high-glucose-induced-downregulation-of-connexin-43-via-ampk-dependent-pathway-in-neonatal-rat-cardiomyocytes
#11
Xiaoting Li, Lu Yu, Jing Gao, Xukun Bi, Juhong Zhang, Shiming Xu, Meihui Wang, Mengmeng Chen, Fuyu Qiu, Guosheng Fu
Diabetes Mellitus is a common disorder, with increasing risk of cardiac arrhythmias. Studies have shown that altered connexin expression and gap junction remodeling under hyperglycemia contribute to the high prevalence of cardiac arrhythmias and even sudden death. Connexin 43 (Cx43), a major protein that assembles to form cardiac gap junctions, has been found to be downregulated under high glucose conditions, along with inhibition of gap junctional intercellular communication (GJIC). While, apelin, a beneficial adipokine, increases Cx43 protein expression in mouse and human embryonic stem cells during cardiac differentiation...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392081/trefoil-factor-3-cholinesterase-and-homocysteine-potential-predictors-for-parkinson-s-disease-dementia-and-vascular-parkinsonism-dementia-in-advanced-stage
#12
Jing Zou, Zhigang Chen, Caiqian Liang, Yongmei Fu, Xiaobo Wei, Jianjun Lu, Mengqiu Pan, Yue Guo, Xinxue Liao, Huifang Xie, Duobin Wu, Min Li, Lihui Liang, Penghua Wang, Qing Wang
Trefoil factor 3 (TFF3), cholinesterase activity (ChE activity) and homocysteine (Hcy) play critical roles in modulating recognition, learning and memory in neurodegenerative diseases, such as Parkinson's disease dementia (PDD) and vascular parkinsonism with dementia (VPD). However, whether they can be used as reliable predictors to evaluate the severity and progression of PDD and VPD remains largely unknown. METHODS: We performed a cross-sectional study that included 92 patients with PDD, 82 patients with VPD and 80 healthy controls...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392080/identification-of-mavs-as-a-novel-risk-factor-for-the-development-of-osteoarthritis
#13
Jie Liu, Ling-Yun Tang, Yan-Gui Wang, Shun-Yuan Lu, En-Ning Zhang, Zhu-Gang Wang, Hong-Xin Zhang
Evidence indicated that inflammatory response and some pattern-recognition receptors play important roles in the occurrence and progression of osteoarthritis. This study is conducted to evaluate the role of RIG-I and its adaptor protein MAVS in the pathogenesis of osteoarthritis. Four SNPs in RIG-I gene and four in MAVS gene were genotyped in 1056 Chinese Han population. We also overexpressed MAVS in murine chondrogenic ATDC5 cells and analyzed the cell viability and apoptosis. Rs11795343 (P-allele : 0.063394) in RIG-I , rs17857295 (P-allele : 0...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392079/novel-modification-of-potassium-chloride-induced-cardiac-arrest-model-for-aged-mice
#14
Huaqin Liu, Zhui Yu, Ying Li, Bin Xu, Baihui Yan, Wulf Paschen, David S Warner, Wei Yang, Huaxin Sheng
Experimental cardiac arrest (CA) in aging research is infrequently studied in part due to the limitation of animal models. We aimed to develop an easily performed mouse CA model to meet this need. A standard mouse KCl-induced CA model using chest compressions and intravenous epinephrine for resuscitation was modified by blood withdrawal prior to CA onset, so as to decrease the requisite KCl dose to induce CA by decreasing the circulating blood volume. The modification was then compared to the standard model in young adult mice subjected to 8 min CA...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392078/parp-1-inhibition-rescues-short-lifespan-in-hyperglycemic-c-elegans-and-improves-glp-1-secretion-in-human-cells
#15
Qianghua Xia, Sumei Lu, Julian Ostrovsky, Shana E McCormack, Marni J Falk, Struan F A Grant
TCF7L2 is located at one of the most strongly associated type 2 diabetes loci reported to date. We previously reported that the most abundant member of a specific protein complex to bind across the presumed causal variant at this locus, rs7903146, was poly [ADP-ribose] polymerase type 1 (PARP-1). We analyzed the impact of PARP-1 inhibition on C. elegans health in the setting of hyperglycemia and on glucose-stimulated GLP-1 secretion in human intestinal cells. Given that high glucose concentrations progressively shorten the lifespan of C...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392077/clinical-profile-of-chinese-long-term-parkinson-s-disease-survivors-with-10-years-of-disease-duration-and-beyond
#16
Qian Sun, Tian Wang, Tian-Fang Jiang, Pei Huang, Ying Wang, Qin Xiao, Jun Liu, Sheng-Di Chen
Background: Parkinson's disease (PD) patients with 10 years or more survival (PD-10) are not well characterized. The aim of this study was to evaluate the main issues facing PD-10 patients and identify factors that independently contributed to quality of life (QoL). Methods: A group of 121 PD-10 patients recruited from outpatient clinics participated in this cross-sectional study. Data on demographic and clinical factors were collected. Multiple linear regression analyses were conducted to identify determinants of poor QoL...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29392076/the-study-of-rhabdomyolysis-in-the-elderly-an-epidemiological-study-and-single-center-experience
#17
Supakanya Wongrakpanich, Christos Kallis, Prithiv Prasad, Janani Rangaswami, Andrew Rosenzweig
Rhabdomyolysis is a syndrome caused by injury to skeletal muscle. There is limited data of rhabdomyolysis in the elderly. The objective of this study is to investigate demographic data, etiologies, laboratory values, prognostic factors, and mortality of rhabdomyolysis in the geriatric population. A 4-years retrospective chart review study was conducted. Our inclusion criteria were age above 65 years and creatinine kinase level excess five times of normal upper limit. Among 167 patients, 47.3% were male. The median age at diagnosis was 80...
February 2018: Aging and Disease
https://www.readbyqxmd.com/read/29344423/age-related-gray-and-white-matter-changes-in-normal-adult-brains
#18
Farnaz Farokhian, Chunlan Yang, Iman Beheshti, Hiroshi Matsuda, Shuicai Wu
Normal aging is associated with both structural changes in many brain regions and functional declines in several cognitive domains with advancing age. Advanced neuroimaging techniques enable explorative analyses of structural alterations that can be used as assessments of such age-related changes. Here we used voxel-based morphometry (VBM) to investigate regional and global brain volume differences among four groups of healthy adults from the IXI Dataset: older females (OF, mean age 68.35 yrs; n=69), older males (OM, 68...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344422/the-effects-of-physical-training-are-varied-and-occur-in-an-exercise-type-dependent-manner-in-elderly-men
#19
Mari L Sbardelotto, Giulia S Pedroso, Fernanda T Pereira, Helen R Soratto, Stella Ms Brescianini, Pauline S Effting, Anand Thirupathi, Renata T Nesi, Paulo Cl Silveira, Ricardo A Pinho
Regular exercise can decrease the deleterious effects of aging and limit the development and progression of chronic disease in elderly people, depending on the type, intensity, frequency, and duration of exercise. This study aimed to investigate the potential protective effects of different physical training programs on oxidative stress parameters and inflammatory and neurotrophic mediators in the serum of elderly men. Healthy male volunteers [60 to 80 years; n=55] were divided into four groups: control [Ctr, n=14], aerobic training on dry land [ATdl, n=12]; and combined training on dry land [CTdl, n=12] or in water [CTw, n=17]...
December 2017: Aging and Disease
https://www.readbyqxmd.com/read/29344421/anti-aging-implications-of-astragalus-membranaceus-huangqi-a-well-known-chinese-tonic
#20
REVIEW
Ping Liu, Haiping Zhao, Yumin Luo
Owing to a dramatic increase in average life expectancy and the Family Planning program of the 1970s - 1990s, China is rapidly becoming an aging society. Therefore, the investigation of healthspan-extending drugs becomes more urgent. Astragalus membranaceus (Huangqi) is a major medicinal herb that has been commonly used in many herbal formulations in the practice of traditional Chinese medicine (TCM) to treat a wide variety of diseases and body disorders, or marketed as life-prolonging extracts for human use in China, for more than 2000 years...
December 2017: Aging and Disease
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