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Journal of Pain Research

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https://www.readbyqxmd.com/read/29042816/incidence-and-predictive-factors-of-spinal-cord-stimulation-treatment-after-lumbar-spine-surgery
#1
Merja Vakkala, Voitto Järvimäki, Hannu Kautiainen, Maija Haanpää, Seppo Alahuhta
INTRODUCTION: Spinal cord stimulation (SCS) is recommended for the treatment of postsurgical chronic back and leg pain refractory to other treatments. We wanted to estimate the incidence and predictive factors of SCS treatment in our lumbar surgery cohort. PATIENTS AND METHODS: Three questionnaires (a self-made questionnaire, the Oswestry Low Back Pain Disability Questionnaire, and the Beck Depression Inventory) were sent to patients aged 18-65 years with no contraindications for the use of SCS, and who had undergone non-traumatic lumbar spine surgery in the Oulu University Hospital between June 2005 and May 2008...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29042815/the-role-of-mir-190a-5p-contributes-to-diabetic-neuropathic-pain-via-targeting-slc17a6
#2
Di Yang, Qinyan Yang, Xinchuan Wei, Yang Liu, Ding Ma, Jiaceng Li, Yongling Wan, Yao Luo
INTRODUCTION: MicroRNAs play a key role in neuropathic pain. In a previous study, miR-190a-5p was significantly downregulated in diabetic neuropathic pain (DNP). However, the role and pathological mechanism of miR-190a-5p in DNP still remain unclear. MATERIALS AND METHODS: DNP model was established. The paw withdrawal thresholds were measured to assess the mechanical nociceptive response. Dual-luciferase reporter assay was used to confirm the target gene of microRNA...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29042814/attenuated-serum-adiponectin-levels-are-associated-with-disease-severity-in-patients-with-non-traumatic-osteonecrosis-of-the-femoral-head
#3
Yong-Bin Yue, Xin Liu, Biao-Fang Wei
OBJECTIVE: Decreased adiponectin (APN) levels have been detected in patients with osteonecrosis of the femoral head (ONFH). The scope of this study was aimed to explore the relationship between serum APN levels and disease severity in nontraumatic ONFH patients. PATIENTS AND METHODS: Ninety two nontraumatic ONFH patients and 92 healthy controls were enrolled for this study following the estimation of sample size. Serum APN concentrations were examined by enzyme-linked immunosorbent assay (ELISA)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29042813/rehabilitation-management-of-low-back-pain-it-s-time-to-pull-it-all-together
#4
Yannick Tousignant-Laflamme, Marc Olivier Martel, Anand B Joshi, Chad E Cook
In the past, rehabilitation research initiatives for low back pain (LBP) have targeted outcome enhancement through personalized treatment approaches, namely through classification systems (CS). Although the use of CS has enhanced outcomes, common management practices have not changed, the prevalence of LBP is still high, and only selected patients meet the CS profile, namely those with a nociceptive context. Similarly, although practice guidelines propose some level of organization and occasionally a timeline of care provision, each mainly provides best practice for isolated treatment approaches...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29042812/age-differences-in-salivary-markers-of-inflammation-in-response-to-experimental-pain-does-venipuncture-matter
#5
Yenisel Cruz-Almeida, Maria Aguirre, Heather Sorenson, Patrick Tighe, Shannon M Wallet, Joseph L Riley
An important consideration in mechanistic research using biomarkers should include the use of saliva as an alternative to blood. The use of saliva would allow the study of susceptible populations such as older adults where venipuncture may not be feasible. Although saliva has been most commonly used to measure cortisol and tumor necrosis factor-α (TNFα), there is limited evidence that other cytokines found in saliva significantly change in response to laboratory-induced pain. Therefore, the aim of the current preliminary study was to characterize the time course, duration and magnitude of changes of commonly measured pro- (interleukin [IL]-6, IL-8) and anti-inflammatory (IL-10, IL-4) cytokines in saliva samples and to test for age-related differences in separate experimental painful and non-painful control sessions...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29042811/optical-inactivation-of-the-anterior-cingulate-cortex-modulate-descending-pain-pathway-in-a-rat-model-of-trigeminal-neuropathic-pain-created-via-chronic-constriction-injury-of-the-infraorbital-nerve
#6
Hyeong Cheol Moon, Won Ik Heo, Yon Ji Kim, Daae Lee, So Yoon Won, Hong Rae Kim, Seung Man Ha, Youn Joo Lee, Young Seok Park
PURPOSE: The anterior cingulate cortex (ACC) plays a critical role in the initiation, development, and maintenance of neuropathic pain. Recently, the effects of optical stimulation on pain have been investigated, but the therapeutic effects of optical stimulation on trigeminal neuralgia (TN) have not been clearly shown. Here, we investigated the effects of optical inhibition of the ACC on TN lesions to determine whether the alleviation of pain affects behavior performance and thalamic neuron signaling...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29042810/changes-in-pain-and-concurrent-pain-medication-use-following-compounded-topical-analgesic-treatment-for-chronic-pain-3-and-6-month-follow-up-results-from-the-prospective-observational-optimizing-patient-experience-and-response-to-topical-analgesics-study
#7
Jeffrey A Gudin, Michael J Brennan, E Dennis Harris, Peter L Hurwitz, Derek T Dietze, James D Strader
BACKGROUND: Opioids and other controlled substances prescribed for chronic pain are associated with abuse, addiction, and death, prompting national initiatives to identify safe and effective pain management strategies including topical analgesics. METHODS: This prospective, observational study evaluated changes from baseline in overall mean severity and interference scores on the Brief Pain Inventory scale and the use of concurrent pain medications at 3- and 6-month follow-up assessments in chronic pain patients treated with topical analgesics...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29033606/the-pain-depression-disability-pathway-in-those-with-low-back-pain-a-moderation-analysis-of-health-locus-of-control
#8
Paul Campbell, Kate Hope, Kate M Dunn
Low back pain (LBP) is common, impacts on the individual and society, and is a major health concern. Psychological consequences of LBP, such as depression, are significant barriers to recovery, but mechanisms for the development of depression are less well understood. One potential mechanism is the individual's health locus of control (HLoC), that is, perception of the level of control an individual has over their health. The objective of this study is to investigate the moderation effect of HLoC on the pain-depression-disability pathway in those with LBP...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29033605/onabotulinum-toxin-a-in-the-treatment-of-chronic-migraine-patient-selection-and-special-considerations
#9
REVIEW
Piero Barbanti, Patrizia Ferroni
Discovered by serendipity, onabotulinum toxin A (BoNT-A) is the only US Food and Drug Administration-approved treatment for the prevention of chronic migraine (CM), one of the most disabling and burdensome human conditions. Its efficacy, safety and tolerability, proved by the largest and longest migraine therapeutic trial (the Phase III Research Evaluating Migraine Prophylaxis Therapy program [PREEMPT]), have been replicated by various real-life studies also in the presence of medication overuse. The benefit of BoNT-A prophylaxis is likely due to its ability to counteract peripheral and central nociceptive sensitization through reversible chemical denervation of pericranial sensitive afferents...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29033604/chronic-pain-and-adult-hippocampal-neurogenesis-translational-implications-from-preclinical-studies
#10
Mariagrazia Grilli
Adult hippocampal neurogenesis (ahNG) occurs in the human brain. Adult generated neurons have been proposed to functionally contribute to relevant hippocampal functions such as learning and memory, mood regulation, and stress response. Learning, environmental enrichment, and physical exercise exert positive effects on ahNG. In parallel, these proneurogenic stimuli have been shown to ameliorate cognitive performance and/or depressive-like behavior in animal models. Conversely, aging, social isolation, and chronic stress exert negative effects on ahNG...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29033603/application-of-the-chronic-constriction-injury-of-the-partial-sciatic-nerve-model-to-assess-acupuncture-analgesia
#11
Mu-Jun Zhi, Kun Liu, Zhou-Li Zheng, Xun He, Tie Li, Guang Sun, Meng Zhang, Fu-Chun Wang, Xin-Yan Gao, Bing Zhu
PURPOSE: To validate and explore the application of a rat model of chronic constriction injury to the partial sciatic nerve in investigation of acupuncture analgesia. METHODS: Chronic constriction injury of the sciatic nerve (CCI) and chronic constriction injury of the partial sciatic nerve (CCIp) models were generated by ligating either the sciatic nerve trunk or its branches in rats. Both models were evaluated via paw mechanical withdrawal latency (PMWL), paw mechanical withdrawal threshold (PMWT), nociceptive reflex-induced electromyogram (C-fiber reflex EMG), and dorsal root ganglion immunohistochemistry...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29026334/an-investigation-into-the-effect-of-depth-of-anesthesia-on-postoperative-pain-in-laparoscopic-cholecystectomy-surgery-a-double-blind-clinical-trial
#12
Seyed Hamid Reza Faiz, Seyed Alireza Seyed Siamdoust, Poupak Rahimzadeh, Leila Houshmand
BACKGROUNDS AND OBJECTIVE: Some studies have shown that deeper anesthesia is more effective on postoperative analgesia and reduces the need for sedative drugs. This study sought to investigate the effect of depth of anesthesia on postoperative pain in laparoscopic cholecystectomy. MATERIALS AND METHODS: In this double-blind clinical trial, 60 patients undergoing laparoscopic cholecystectomy were randomly divided into two groups: low bispectral index (L-BIS=35-44) and high bispectral index (H-BIS=45-55)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29026333/analgesic-efficacy-and-safety-of-epidural-oxycodone-in-patients-undergoing-total-hip-arthroplasty-a-pilot-study
#13
Bogumił Olczak, Grzegorz Kowalski, Wojciech Leppert, Agnieszka Bienert, Artur Teżyk, Michał Adamski, Stanisław Rzymski, Katarzyna Wieczorowska-Tobis
BACKGROUND AND OBJECTIVES: Oxycodone is poorly studied as an adjuvant to central blockades. The aim of this pilot study was to assess the efficacy and safety of oxycodone hydrochloride in epidural blockade among patients undergoing total hip arthroplasty (THA). PATIENTS AND METHODS: In 11 patients (American Society of Anesthesiologists physical status classification system II/III, age range: 59-82 years), THA was conducted with an epidural blockade using 15 mL 0...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29026332/ultrasound-guided-methotrexate-injection-for-de-quervain-disease-of-the-wrist-what-lies-beyond-the-horizon
#14
Abdallah El-Sayed Allam, Doaa Shawky Al-Ashkar, Ahmed A Negm, Basma Aly Eltawab, Wei-Ting Wu, Ke-Vin Chang
De Quervain disease (DQVD) is one of the most common causes of lateral wrist pain and can lead to significant disability. The current case involves a right-handed, middle-aged, female patient with severe lateral wrist pain due to DQVD. Her pain was not responsive to oral non-steroidal anti-inflammatory drugs, rehabilitation, and repeated corticosteroid injections. Because she refused surgical intervention, we performed ultrasound-guided methotrexate injections (four times). After the injections, dramatic pain relief, functional improvement, and reduction of the thickness of the retinaculum and tendons in the first dorsal extensor compartment of the wrist were noted...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29026331/poorly-controlled-postoperative-pain-prevalence-consequences-and-prevention
#15
REVIEW
Tong J Gan
This review provides an overview of the clinical issue of poorly controlled postoperative pain and therapeutic approaches that may help to address this common unresolved health-care challenge. Postoperative pain is not adequately managed in greater than 80% of patients in the US, although rates vary depending on such factors as type of surgery performed, analgesic/anesthetic intervention used, and time elapsed after surgery. Poorly controlled acute postoperative pain is associated with increased morbidity, functional and quality-of-life impairment, delayed recovery time, prolonged duration of opioid use, and higher health-care costs...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28979162/pain-problems-for-patients-with-mild-and-moderate-chronic-obstructive-pulmonary-disease-a-community-based-study-in-shanghai
#16
Tian Xiao, Xianfeng Zhou, Yun He, Yue Chen, Hua Qiu, Sheng Zhang, Xianglin Wei, Kang Wu, Xiaonan Ruan, Na Wang, Chaowei Fu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a great public health burden worldwide. Few studies have focused on pain problems in patients with mild and moderate COPD in Chinese community settings. METHODS: A cross-sectional study of 283 patients with mild and moderate COPD was conducted in six communities that were randomly sampled in Pudong New Area of Shanghai, China, in 2016. A face-to-face interview was conducted to collect data on personal characteristics and health conditions...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28979161/uncovering-the-influence-of-social-skills-and-psychosociological-factors-on-pain-sensitivity-using-structural-equation-modeling
#17
Yoichi Tanaka, Yuki Nishi, Yuki Nishi, Michihiro Osumi, Shu Morioka
Pain is a subjective emotional experience that is influenced by psychosociological factors such as social skills, which are defined as problem-solving abilities in social interactions. This study aimed to reveal the relationships among pain, social skills, and other psychosociological factors by using structural equation modeling. A total of 101 healthy volunteers (41 men and 60 women; mean age: 36.6±12.7 years) participated in this study. To evoke participants' sense of inner pain, we showed them images of painful scenes on a PC screen and asked them to evaluate the pain intensity by using the visual analog scale (VAS)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28979160/preconditioning-by-light-load-eccentric-exercise-is-equally-effective-as-low-level-laser-therapy-in-attenuating-exercise-induced-muscle-damage-in-collegiate-men
#18
Samar Nausheen, Jamal Ali Moiz, Shahid Raza, Mohammad Yakub Shareef, Shahnawaz Anwer, Ahmad H Alghadir
BACKGROUND/OBJECTIVE: Previous studies have already reported an independent effect of light-load eccentric exercise (10% eccentric exercise contraction [EEC]) and low-level laser therapy (LLLT) as a protective measure against more strenuous eccentric exercise. However, the difference between these two interventions is largely unknown. Therefore, the present study aimed to compare the preconditioning effect of 10% EEC vs. LLLT on subjective, physiological, and biochemical markers of muscle damage in elbow flexors in collegiate men...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28979159/sound-stress-induced-altered-nociceptive-behaviors-are-associated-with-increased-spinal-crfr2-gene-expression-in-a-rat-model-of-burn-injury
#19
Natasha M Sosanya, Alex V Trevino, Roger L Chavez, Robert J Christy, Bopaiah P Cheppudira
Sound stress (SS) elicits behavioral changes, including pain behaviors. However, the neuronal mechanisms underlying SS-induced pain behaviors remain to be explored. The current study examined the effects of SS on nociceptive behaviors and changes in expression of the spinal corticotropin-releasing factor (CRF) system in male Sprague Dawley rats with and without thermal pain. We also studied the effects of SS on plasma corticosterone and fecal output. Rats were exposed to 3 days of SS protocol (n = 12/group)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28979158/the-central-sensitization-inventory-validated-and-adapted-for-a-brazilian-population-psychometric-properties-and-its-relationship-with-brain-derived-neurotrophic-factor
#20
Wolnei Caumo, Luciana C Antunes, Jéssica Lorenzzi Elkfury, Evelyn G Herbstrith, Raquel Busanello Sipmann, Andressa Souza, Iraci Ls Torres, Vinicius Souza Dos Santos, Randy Neblett
OBJECTIVES: The primary aim was to assess the psychometric properties (including internal consistency, construct validity, reproducibility, and factor structure) of the Central Sensitization Inventory (CSI), adapted and validated for a Brazilian population (CSI-BP). Additionally, we evaluated the relationship between the CSI-BP and the serum brain-derived neurotrophic factor (BDNF) and determined if the symptoms elicited by the CSI-BP discriminate between subjects who do/do not respond to the conditioned pain modulation (CPM) task, as assessed by change in numeric pain scale (0-10) score...
2017: Journal of Pain Research
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