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Journal of Pain Research

Jessica C Oswald, Nathaniel M Schuster
Now that the vascular hypothesis of migraine is no longer the prevailing theory of migraine pathogenesis, there is interest in developing acute migraine treatments that act exclusively on non-vascular targets. There is a large percentage of non-responders to current acute migraine treatments and the vasoconstriction associated with triptans limit their use in patients with pre-existing cardiovascular risk factors. Preferential 5-HT1F agonists have shown promising results in in vitro and early proof-of-concept trials...
2018: Journal of Pain Research
John Sunwoo, Patjanaporn Chalacheva, Maha Khaleel, Payal Shah, Richard Sposto, Roberta M Kato, Jon Detterich, Lonnie K Zeltzer, John C Wood, Thomas D Coates, Michael Ck Khoo
Purpose: The purpose of this work was to noninvasively detect and quantify microvascular blood flow changes in response to externally applied pain in humans. The responsiveness of the microvasculature to pain stimulation might serve as an objective biomarker in diseases associated with altered pain perception and dysregulated vascular functions. The availability of such a biomarker may be useful as a tool for predicting outcome and response to treatments, particularly in diseases like sickle cell anemia where clinical manifestations are directly linked to microvascular perfusion...
2018: Journal of Pain Research
Akiko Okamoto, Masaki Yamasaki, Isao Yokota, Maiko Mori, Megumi Matsuda, Yosuke Yamaguchi, Shunsuke Yamakita, Hiroshi Ueno, Teiji Sawa, Tetsuya Taguchi, Toyoshi Hosokawa, Fumimasa Amaya
Purpose: Predictive value and accuracy of the acute pain trajectory were compared with those of pain intensity at 1 day after the surgery for pain prevalence at 6 months after the surgery. Materials and methods: Female patients scheduled for breast cancer surgery were eligible for this study. Patients were questioned about pain intensity daily during the 7 days after surgery. Presence of pain, its location, and intensity as well as the Japanese version of the quality of the recovery-40 (QOR-40) were determined in an interview prior to and at 6 months after the surgery...
2018: Journal of Pain Research
Juan C Mora, Rene Przkora, Yenisel Cruz-Almeida
For decades, multiple attempts to fully understand knee osteoarthritis pathophysiology and natural history have been attempted. Despite the extensive amount of research regarding this topic, there are still marked controversies. This multifactorial condition gets influenced by local, systemic, and external factors and its progression and/or response to treatments widely varies from patient to patient. Multiple therapies have been studied in the past, low impact physical activity seems to be supported by all the current medical societies while other interventions have shown conflicting findings...
2018: Journal of Pain Research
Si-Yu Lin, Shi-Zhong Zhang, Jian-Xiong An, Xiao-Yan Qian, Xin-You Gao, Yong Wang, Wen-Xing Zhao, Derek Eastwood, Doris K Cope, John P Williams
Objective: This study was to evaluate the effectiveness of ultrasound-guided percutaneous ozone injections around the cervical dorsal root ganglions of zoster-associated pain (ZAP) patients. Study design: Retrospective comparative study. Settings: The study was conducted at a pain center of a university hospital. Patients and methods: From June 2016 to July 2017, a total number of 30 patients with ZAP were treated with ultrasound-guided percutaneous ozone injection around the cervical dorsal root ganglion (DRG) at the injured nerve level (C2-C8)...
2018: Journal of Pain Research
Milly Buwenge, Gabriella Macchia, Alessandra Arcelli, Rezarta Frakulli, Lorenzo Fuccio, Sara Guerri, Elisa Grassi, Silvia Cammelli, Francesco Cellini, Alessio G Morganti
Locally advanced pancreatic carcinoma (LAPC) has a poor prognosis and the purpose of treatment is survival prolongation and symptom palliation. Radiotherapy has been reported to reduce pain in LAPC. Stereotactic RT (SBRT) is considered as an emerging radiotherapy technique able to achieve high local control rates with acceptable toxicity. However, its role in pain palliation is not clear. To review the impact on pain relief with SBRT in LAPC patients, a literature search was performed on PubMed, Scopus, and Embase (January 2000-December 2017) for prospective and retrospective articles published in English...
2018: Journal of Pain Research
Yukiko Shiro, Tatsunori Ikemoto, Kazuhiro Hayashi, Young-Chang Arai, Masataka Deie, Takefumi Ueno
Aim: Operant conditioning has long been believed to influence the pain experience through a psychological reward pathway. This study was formulated to test the hypothesis that pain sensitivity may be enhanced >3 months if a monetary reward works as a reinforcement. Methods: Forty healthy subjects volunteered to participate in this study. The subjects repeatedly underwent pain testing via mechanical stimuli, and they rolled dice three (or six) times to gain money at the following five time points: baseline, three reinforcement sessions, and last session...
2018: Journal of Pain Research
Albert Feliu-Soler, Francisco Montesinos, Olga Gutiérrez-Martínez, Whitney Scott, Lance M McCracken, Juan V Luciano
It is well known that chronic pain is prevalent, complex to manage, and associated with high costs, in health care and society in general. Thanks to advances in new forms of cognitive behavioral therapy (known as third-wave CBT), currently clinicians and researchers have an empirically validated psychological treatment with increasing research support for the treatment of chronic pain. This treatment is called acceptance and commitment therapy (ACT). The main aim of this paper is to provide a narrative review that summarizes and integrates the current state of knowledge of ACT in the management of chronic pain as well as discuss current challenges and opportunities for progress...
2018: Journal of Pain Research
Jun Li, Xuehua Huang, Kangning Sang, Mark Bodner, Ke Ma, Xiao-Wei Dong
Background: Although the interaction between pain and cognition has been recognized for decades, the neural substrates underlying their association remain unclear. The prefrontal cortex (PFC) is known as a critical brain area for higher cognitive functions, as well as for pain perception and modulation. The objective of the present study was to explore the role of the PFC in the interaction between chronic pain and cognitive functions by examining the relationship between spontaneous activity in the frontal lobe and pain intensity reported by postherpetic neuralgia (PHN) patients...
2018: Journal of Pain Research
Felipe Chiodini Machado, Claudia Carneiro de Araújo Palmeira, João Nathanael Lima Torres, Joaquim Edson Vieira, Hazem Adel Ashmawi
Objectives: Surgical patients still commonly experience postoperative pain. With the increasing prevalence of obesity, there is a growing demand for surgical procedures by this population. Intraoperative use of methadone has not been well assessed in this population. Materials and methods: Patients with a body mass index of 35 kg/m2 or more undergoing bariatric surgery were randomly assigned to receive either fentanyl (group F) or methadone (group M) in anesthesia induction and maintenance...
2018: Journal of Pain Research
Zi Xuan Wang, Lin Li, Feng Ying Tao
Aim: Psychological intervention has been proved a complementary approach to drug analgesia. Another study suggested that health knowledge is associated with psychological symptoms in patients with liver cancer. This study is conducted to assess whether improving the health education (HE) alleviates the postembolization pain during transarterial chemoembolization (TACE). Materials and methods: One hundred and fifteen patients, who required TACE for hepatocellular carcinoma (HCC) and suffered postembolization pain, were randomized into control group (n=63) and HE group (n=52)...
2018: Journal of Pain Research
Nasrin Ghanbari Nia, Ardashir Afrasiabifar, Mohammad Behnammoghadam
Objective: Previous studies reported the reduction of pain following eye movement desensitization and reprocessing (EMDR) and guided imagery; however, the effectiveness of these modalities was not compared. The current study aimed to compare the effects of EMDR and guided imagery on pain severity in patients with rheumatoid arthritis. Material and methods: In this randomized controlled trial, 75 patients were selected using non-random method, and then allocated into two intervention groups and one control group...
2018: Journal of Pain Research
Xiang Zhu, Yuxi Liu, Hongfang Huang, Yonghua Zhang, Saisai Huang, Weiwei Zhou, Xiaocui Bian, Shiren Shen, Su Cao
Purpose: Postoperative pain is a common clinical problem. In this study, we aimed to investigate the role of protein kinase C βII (PKCβII) in the progression of postoperative pain following skin/muscle incision and retraction (SMIR) surgery. Materials and methods: SMIR postoperative pain model was established in rats, akin to a clinical procedure. The expression level and location of p-PKCβII were observed in dorsal root ganglion (DRG) or spinal cord from SMIR-operated rats by Western blotting and immunofluorescence...
2018: Journal of Pain Research
Ana B Gago-Veiga, Josué Pagán, Kevin Henares, Patricia Heredia, Nuria González-García, María-Irene De Orbe, Jose L Ayala, Mónica Sobrado, Jose Vivancos
Purpose: Premonitory symptoms (PSs) of migraine are those that precede pain in a migraine attack. Previous studies suggest that treatment during this phase may prevent the onset of pain; however, this approach requires that patients be able to recognize their PSs. Our objectives were to evaluate patients' actual ability to predict migraine attacks based on their PSs and analyze whether good predictors meet any characteristic profile. Patients and methods: This prospective, observational study included patients with migraine with and without aura...
2018: Journal of Pain Research
Hyochol Ahn, Robert Suchting, Adam J Woods, Hongyu Miao, Charles Green, Raymond Y Cho, Eunyoung Choi, Roger B Fillingim
Purpose: Previous studies have indicated that transcranial direct current stimulation (tDCS) with the anode over the motor cortex and the cathode over the contralateral supraorbital region is effective in reducing clinical pain in patients with chronic pain, but these studies have not focused on experimental pain sensitivity. Therefore, the aim of this study was to examine the effect of tDCS on experimental pain sensitivity in older adults with knee osteoarthritis (OA). Patients and methods: Forty community-dwelling participants aged 50-70 years with knee OA pain were randomly assigned to receive five daily sessions of 2 mA tDCS for 20 minutes (n = 20) or sham tDCS (n = 20) using a parallel group design...
2018: Journal of Pain Research
Guang-Xia Shi, Bao-Zhen Liu, Jun Wang, Qing-Nan Fu, San-Feng Sun, Rui-Li Liang, Jing Li, Jian-Feng Tu, Cheng Tan, Cun-Zhi Liu
Background: Strategies for preventing the persistence of pain and disability beyond the acute phase in shoulder pain patients are critically needed. Conventional acupuncture therapy (CAT) or motion style acupuncture therapy (MSAT) alone results in relative improvements in painful conditions in shoulder pain patients; combined interventions may have more global effects. The aim of this study is to evaluate the efficacy and safety of MSAT vs CAT for shoulder pain. Methods: A randomized controlled trial using a factorial design was conducted from January 2014 to December 2015...
2018: Journal of Pain Research
In Chan Baek, Kyungeun Park, Tae Lim Kim, Jehoon O, Hun-Mu Yang, Shin Hyung Kim
Purpose: The spread patterns between different injectate volumes have not yet been investigated in ultrasound-guided greater occipital nerve (GON) block at the C2 level. This cadaveric study was undertaken to compare the spread pattern and nerve involvements of different volumes of dye using this technique. Materials and methods: After randomization, ultrasound-guided GON blocks with 1 or 5 mL dye solution were performed at the C2 level on the right or left side of five fresh cadavers...
2018: Journal of Pain Research
Hyun-Jin Kwon, Hong-San Kim, Jehoon O, Hyo Jong Kang, Ji Yeon Won, Hun-Mu Yang, Shin Hyung Kim, You-Jin Choi
Purpose: Establishing the distribution patterns of occipital cutaneous nerves may help us understand their contribution to various occipital pain patterns and ensure that a proper local injection method for treatment is employed. The aim of this study was to demonstrate the detailed distribution patterns of the greater occipital nerve (GON), lesser occipital nerve (LON), and third occipital nerve (TON) using the modified Sihler's staining technique. Methods: Ten human cadavers were manually dissected to determine the nerve distributions...
2018: Journal of Pain Research
Annamária Fejes-Szabó, Eleonóra Spekker, Lilla Tar, Gábor Nagy-Grócz, Zsuzsanna Bohár, Klaudia Flóra Laborc, László Vécsei, Árpád Párdutz
Background: The prevalence of craniofacial pain disorders show sexual dimorphism with generally more common appearance in women suggesting the influence of estradiol, but the exact cause remains unknown. The common point in the pathogenesis of these disorders is the activation of trigeminal system. One of the animal experimental models of trigeminal activation is the orofacial formalin test, in which we investigated the effect of chronic 17β-estradiol pretreatment on the trigeminal pain-related behavior and activation of trigeminal second-order neurons at the level of spinal trigeminal nucleus pars caudalis (TNC)...
2018: Journal of Pain Research
Yanchun Liang, Duo Liu, Fan Yang, Wenwei Pan, Feitianzhi Zeng, Jinjie Wu, Hongyu Xie, Jiaying Li, Shuzhong Yao
Purpose: Recent studies have shown that abnormal distribution of pelvic nerves contributes to endometriosis-associated pain. However, the relationship between neurogenesis and pain severity in endometriosis still remains uncertain, which makes it an enigma for both gynecologists as well as neuropathologists. In this study, we tried to explore a special phenomenon, perineural invasion (PNI), in deep infiltrating endometriosis (DIE) and investigated the correlation between PNI- and DIE-associated pain...
2018: Journal of Pain Research
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