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Journal of Pain Research

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https://www.readbyqxmd.com/read/29445298/presence-of-pain-on-three-or-more-days-of-the-week-is-associated-with-worse-patient-reported-outcomes-in-adults-with-sickle-cell-disease
#1
Nitya Bakshi, Diana Ross, Lakshmanan Krishnamurti
While acute episodic pain is the hallmark of sickle cell disease (SCD), transition to chronic pain is a major cause of morbidity and impaired quality of life. One of the core diagnostic criteria used by Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society Pain Taxonomy (AAPT) to define chronic SCD pain is the presence of pain on a "majority of days" in the past 6 months in one or more locations. The frequency characteristic of "majority of days" is adapted from the criteria of 15 days or more per month, used to define chronic migraine, but there are inadequate data to support this cutoff in SCD...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29445297/managing-severe-pain-and-abuse-potential-the-potential-impact-of-a-new-abuse-deterrent-formulation-oxycodone-naltrexone-extended-release-product
#2
REVIEW
Joseph V Pergolizzi, Robert Taylor, Jo Ann LeQuang, Robert B Raffa
Proper management of severe pain represents one of the most challenging clinical dilemmas. Two equally important goals must be attained: the humanitarian/medical goal to relieve suffering and the societal/legal goal to not contribute to the drug abuse problem. This is an age-old problem, and the prevailing emphasis placed on one or the other goal has resulted in pendulum swings that have resulted in either undertreatment of pain or the current epidemic of misuse and abuse. In an effort to provide efficacious strong pain relievers (opioids) that are more difficult to abuse by the most dangerous routes of administration, pharmaceutical companies are developing products in which the opioid is manufactured in a formulation that is designed to be tamper resistant...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29445296/the-ultrasound-guided-retrolaminar-block-volume-dependent-injectate-distribution
#3
Marija Damjanovska, Tatjana Stopar Pintaric, Erika Cvetko, Kamen Vlassakov
Purpose: The ultrasound-guided retrolaminar block is one of the newer and simpler alternatives to the traditional, often technically challenging, paravertebral (PV) block. Its feasibility, safety, and efficacy have already been clinically demonstrated in patients with multiple rib fractures using higher volumes of local anesthetic, when compared with the traditional approach. The primary aim of this observational anatomical study was to assess the spread of local anesthetic from the retrolaminar injection point to the PV space and its volume dependence...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29445295/the-effect-of-exercise-frequency-on-neuropathic-pain-and-pain-related-cellular-reactions-in-the-spinal-cord-and-midbrain-in-a-rat-sciatic-nerve-injury-model
#4
Megumi Sumizono, Harutoshi Sakakima, Shotaro Otsuka, Takuto Terashi, Kazuki Nakanishi, Koki Ueda, Seiya Takada, Kiyoshi Kikuchi
Background: Exercise regimens are established methods that can relieve neuropathic pain. However, the relationship between frequency and intensity of exercise and multiple cellular responses of exercise-induced alleviation of neuropathic pain is still unclear. We examined the influence of exercise frequency on neuropathic pain and the intracellular responses in a sciatic nerve chronic constriction injury (CCI) model. Materials and methods: Rats were assigned to four groups as follows: CCI and high-frequency exercise (HFE group), CCI and low-frequency exercise (LFE group), CCI and no exercise (No-Ex group), and naive animals (control group)...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29440925/chronic-back-pain-cured-by-low-dose-levodopa-is-it-a-variant-of-restless-legs-syndrome
#5
Zhi-Fen Zeng, Yan-Ran Liang, Ying Chen, Xiu-Na Jing, Su-Dan Peng, En-Xiang Tao
Chronic back pain is one of the most common reasons for missed work and visits to the doctor. This report presents 2 interesting cases of chronic back pain that were effectively relieved by low-dose levodopa. These 2 patients showed no sign of anatomical problem of the spine or relative structures, but the discomforts on the back manifested some characteristics resembling those in restless legs syndrome (RLS), and one of them actually developed RLS after many years of back problem. We believe that this type of chronic back pain might be a variant of RLS, which we would like to call "restless back", and it can be effectively treated by dopaminergic drugs...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29430196/clinimetric-properties-of-the-nepali-version-of-the-pain-catastrophizing-scale-in-individuals-with-chronic-pain
#6
Saurab Sharma, Pascal Thibault, J Haxby Abbott, Mark P Jensen
Background: Pain catastrophizing is an exaggerated negative cognitive response related to pain. It is commonly assessed using the Pain Catastrophizing Scale (PCS). Translation and validation of the scale in a new language would facilitate cross-cultural comparisons of the role that pain catastrophizing plays in patient function. Purpose: The aim of this study was to translate and culturally adapt the PCS into Nepali (Nepali version of PCS [PCS-NP]) and evaluate its clinimetric properties...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29430195/computed-tomography-guided-percutaneous-ozone-injection-of-the-gasserian-ganglion-for-the-treatment-of-trigeminal-neuralgia
#7
Jian-Xiong An, Hui Liu, Ruo-Wen Chen, Yong Wang, Wen-Xing Zhao, Derek Eastwood, John P Williams
Objective: The aim of this study was to evaluate the therapeutic effect of computed tomography (CT)-guided percutaneous ozone injection for refractory trigeminal neuralgia. Design: A retrospective evaluation was performed in the study. Setting: The study was conducted at a university hospital pain center. Patients and methods: A total of 29 patients with a clinical diagnosis of refractory trigeminal neuralgia were enrolled...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29416373/as-if-one-pain-problem-was-not-enough-prevalence-and-patterns-of-coexisting-chronic-pain-conditions-and-their-impact-on-treatment-outcomes
#8
M Gabrielle Pagé, Maude Fortier, Mark A Ware, Manon Choinière
Introduction: The presence of multiple coexisting chronic pain (CP) conditions (eg, low-back pain and migraines) within patients has received little attention in literature. The goals of this observational longitudinal study were to determine the prevalence of coexisting CP conditions, identify the most frequent ones and patterns of coexistence, investigate the relationships among patients' biopsychosocial characteristics and number of CP conditions, and determine the impact of coexisting CP conditions on treatment response...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29416372/effect-of-bupivacaine-and-adjuvant-drugs-for-regional-anesthesia-on-nerve-tissue-oximetry-and-nerve-blood-flow
#9
Thomas Wiesmann, Stefan Müller, Hans-Helge Müller, Hinnerk Wulf, Thorsten Steinfeldt
Background: Nerve blood flow has a critical role in acute and chronic pathologies in peripheral nerves. Influences of local anesthetics and adjuvants on tissue perfusion and oxygenation are deemed as relevant factors for nerve damage after peripheral regional anesthesia. The link between low tissue perfusion due to local anesthetics and resulting tissue oxygenation is unclear. Methods: Combined tissue spectrophotometry and laser-Doppler flowmetry were used to assess nerve blood flow in 40 surgically exposed median nerves in pigs, as well as nerve tissue oximetry for 60 min...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29406534/erratum-calcitonin-gene-related-peptide-receptor-as-a-novel-target-for-the-management-of-people-with-episodic-migraine-current-evidence-and-safety-profile-of-erenumab-corrigendum
#10
(no author information available yet)
[This corrects the article on p. 2751 in vol. 10, PMID: 29263689.].
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29403305/spotlight-on-topographical-pressure-pain-sensitivity-maps-a-review
#11
REVIEW
Francisco Alburquerque-Sendín, Pascal Madeleine, César Fernández-de-Las-Peñas, Paula Rezende Camargo, Tania Fátima Salvini
Mechanical hyperalgesia defined as decreased pressure pain thresholds (PPTs) is commonly associated with pain. In this narrative review, we report the current state of the art within topographical pressure sensitivity maps. Such maps are based on multiple PPT assessments. The PPTs are assessed by an a priori defined grid with special focus on both spatial and temporal summation issues. The grid covers the muscle or the body region of interest using absolute or relative values determined from anatomical landmarks or anthropometric values...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29391827/development-and-implementation-of-an-inpatient-multidisciplinary-pain-management-program-for-patients-with-intractable-chronic-musculoskeletal-pain-in-japan-preliminary-report
#12
Naoto Takahashi, Satoshi Kasahara, Shoji Yabuki
Introduction: Multidisciplinary pain management is a useful method to treat chronic musculoskeletal pain. Few facilities in Japan administer a multidisciplinary pain management program, especially an inpatient program. Therefore, we implemented a multidisciplinary pain management program in our hospital based on biopsychosocial factors guided by the recommendations of the International Association for the Study of Pain. The purpose of this study is to describe our inpatient pain management program for Japanese patients, which uses the biopsychosocial method of pain self-management...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29391826/spotlight-on-naldemedine-in-the-treatment-of-opioid-induced-constipation-in-adult-patients-with-chronic-noncancer-pain-design-development-and-place-in-therapy
#13
REVIEW
Emily K Stern, Darren M Brenner
Opioid-induced constipation (OIC) is an increasingly prevalent problem in the USA due to the growing use of opioids. A novel class of therapeutics, the peripherally acting μ-opioid receptor antagonists (PAMORAs), has been developed to mitigate the deleterious effects of opioids in the gastrointestinal tract while maintaining central analgesia and minimizing opioid withdrawal. This review aimed to summarize the literature on naldemedine, the third PAMORA to gain US Food and Drug Administration (FDA) approval for the treatment of OIC in adults with chronic noncancer pain-related syndromes...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29391825/tramadol-use-in-a-patient-with-brugada-syndrome-and-morphine-allergy-a-case-report
#14
Cengiz Sahutoglu, Seden Kocabas, Fatma Zekiye Askar
Brugada syndrome is a rare syndrome characterized by arrhythmias and sudden death, particularly in younger individuals. A mutation in a gene encoding the human cardiac sodium channels is responsible for this syndrome. In the literature, there are several case reports of Brugada syndrome in association with the use of several anesthetic agents. Herein, we present our anesthetic practice and the use of tramadol in a 75-year-old female patient who underwent pulmonary lobectomy under general anesthesia and was diagnosed with Brugada syndrome...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29391824/altered-perfusion-of-the-sensorimotor-cortex-in-patients-with-cervical-spondylotic-myelopathy-an-arterial-spin-labeling-study
#15
Fuqing Zhou, Muhua Huang, Lin Wu, Yongming Tan, Jianqiang Guo, Yong Zhang, Laichang He, Honghan Gong
Objective: Advanced magnetic resonance imaging studies have shown functional plasticity or reorganization and metabolite alterations of N-acetyl aspartate in the sensorimotor cortex (SMC), a hallmark region and key brain network, in patients with cervical spondylotic myelopathy (CSM). However, the nature of perfusion in the SMC and the relationship between regional cerebral blood flow (CBF), motor function scores, and structural damage of the cervical cord in patients with CSM are not fully understood...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29386913/altered-low-frequency-oscillation-amplitude-of-resting-state-fmri-in-patients-with-discogenic-low-back-and-leg-pain
#16
Fuqing Zhou, Lili Gu, Shunda Hong, Jiaqi Liu, Jian Jiang, Muhua Huang, Yong Zhang, Honghan Gong
Objective: The aim of this study was to explore the amplitude of intrinsic low-frequency oscillations (LFOs) in patients with discogenic low-back and leg pain (LBLP). Participants and methods: We obtained and compared the LFO amplitude from 25 right-handed discogenic LBLP patients (13 males; mean age 55.16±1.83 years) and 27 well-matched healthy controls (15 males; mean age 52.96±1.63 years). The LFO amplitude was examined using the voxel-wise amplitude of low-frequency fluctuations (ALFFs), and partial correlation analysis was performed to determine the relationship between the regions with altered ALFF values and clinical parameters in discogenic LBLP patients...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29386912/safety-and-efficacy-of-subcutaneous-tanezumab-in-patients-with-knee-or-hip-osteoarthritis
#17
Charles Birbara, Eugene J Dabezies, Aimee M Burr, Robert J Fountaine, Michael D Smith, Mark T Brown, Christine R West, Rosalin H Arends, Kenneth M Verburg
Background/objective: The objective of this study was to investigate the safety and efficacy of subcutaneous (SC) and intravenous (IV) tanezumab administration in osteoarthritis (OA) patients. Materials and methods: Study 1027 (NCT01089725), a placebo-controlled trial, evaluated the efficacy of SC tanezumab (ie, 2.5, 5, and 10 mg) and the therapeutic equivalence of 10 mg tanezumab given subcutaneously versus intravenously every 8 weeks in the symptomatic treatment of OA...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29379315/the-rs4846049-polymorphism-in-the-3-utr-region-of-the-mthfr-gene-increases-the-migraine-susceptibility-in-an-iranian-population
#18
Mohaddeseh Salehi, Mona Amin-Beidokhti, Behnam Safarpour Lima, Milad Gholami, Gholam-Reza Javadi, Reza Mirfakhraie
Introduction: Migraine is a painful complex neurovascular disease characterized by recurrent moderate-to-severe headaches. Increased level of homocysteine is related to dilation of cerebral vessels and endothelial injury that could trigger migraine attacks. Functional polymorphisms in the MTHFR gene affect homocysteine metabolism and, therefore, play an important role in the etiology of the disease. Objectives: We aimed to investigate the possible association between MTHFR gene rs4846049, C677T, and A1298C polymorphisms and the risk of migraine in Iranian population...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29379314/experiences-and-attitudes-about-physical-activity-and-exercise-in-patients-with-chronic-pain-a-qualitative-interview-study
#19
Linn Karlsson, Björn Gerdle, Esa-Pekka Takala, Gerhard Andersson, Britt Larsson
Purpose: The purpose of this study was to describe how patients with chronic pain experience physical activity and exercise (PA&E). Method: This qualitative interview study included 16 women and two men suffering from chronic pain and referred to a multimodal pain rehabilitation program. Semi-structured interviews were conducted and qualitative content analysis was used to analyze the interviews. Results: One main theme emerged: "To overcome obstacles and to seize opportunities to be physically active despite chronic pain...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29379313/a-prospective-longitudinal-study-to-evaluate-the-clinical-utility-of-a-predictive-algorithm-that-detects-risk-of-opioid-use-disorder
#20
Ashley Brenton, Chee Lee, Katrina Lewis, Maneesh Sharma, Svetlana Kantorovich, Gregory A Smith, Brian Meshkin
Purpose: The purpose of this study was to determine the clinical utility of an algorithm-based decision tool designed to assess risk associated with opioid use. Specifically, we sought to assess how physicians were using the profile in patient care and how its use affected patient outcomes. Patients and methods: A prospective, longitudinal study was conducted to assess the utility of precision medicine testing in 5,397 patients across 100 clinics in the USA. Using a patent-protected, validated algorithm combining specific genetic risk factors with phenotypic traits, patients were categorized into low-, moderate-, and high-risk patients for opioid abuse...
2018: Journal of Pain Research
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