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Journal of Pain Research

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https://www.readbyqxmd.com/read/28331361/maternal-anxiety-and-its-correlation-with-pain-experience-during-chorion-villus-sampling-and-amniocentesis
#1
Katharina Klages, Sudip Kundu, Joachim Erlenwein, Michael Elsaesser, Peter Hillemanns, Alexander Scharf, Ismini Staboulidou
PURPOSE: Invasive prenatal diagnostic procedures, such as chorion villus sampling (CVS) and amniocentesis (AC), are routinely performed to exclude or diagnose fetal chromosomal abnormalities. The aim of this study was to investigate anxiety-dependent pain experience during CVS and AC and the potential factors that increase anxiety and pain levels. PATIENTS AND METHODS: During a 2-year period, women undergoing invasive procedures in three specialist centers were asked to participate in the study...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28331360/clear-differences-in-cerebrospinal-fluid-proteome-between-women-with-chronic-widespread-pain-and-healthy-women-a-multivariate-explorative-cross-sectional-study
#2
Patrik Olausson, Bijar Ghafouri, Emmanuel Bäckryd, Björn Gerdle
INTRODUCTION: Frequent chronic local pain can develop into chronic widespread pain (CWP). The spread of pain is correlated with pain intensity, anxiety, and depression, conditions that ultimately lead to a poor quality of life. Knowledge is incomplete about CWP's etiology, although it has been suggested that both central hyperexcitability and/or a combination with peripheral factors may be involved. Cerebrospinal fluid (CSF) could act as a mirror for the central nervous system as proteins are signal substances that activate the formation of algesics and control nociceptive processes...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28331359/pregnancy-suppresses-neuropathic-pain-induced-by-chronic-constriction-injury-in-rats-through-the-inhibition-of-tnf-%C3%AE
#3
Yoshiko Onodera, Megumi Kanao-Kanda, Hirotsugu Kanda, Tomoki Sasakawa, Hiroshi Iwasaki, Takayuki Kunisawa
PURPOSE: Pregnancy-induced analgesia develops during late pregnancy, but it is unclear whether this analgesia is effective against neuropathic pain. The detailed molecular mechanisms underlying pregnancy-induced analgesia have not been investigated. We examined the antinociceptive effect of pregnancy-induced analgesia in a neuropathic pain model and the expression of tumor necrosis factor (TNF)-α, glial fibrillary acidic protein (GFAP), Iba-1, and c-Fos in the spinal dorsal horn just before parturition...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28331358/pain-behavior-mediates-the-relationship-between-perceived-injustice-and-opioid-prescription-for-chronic-pain-a-collaborative-health-outcomes-information-registry-study
#4
Junie S Carriere, Marc-Olivier Martel, Ming-Chih Kao, Michael Jl Sullivan, Beth D Darnall
BACKGROUND AND PURPOSE: Perceived injustice has been defined as an appraisal regarding the severity and irreparability of loss associated with pain, blame and a sense of unfairness. Recent findings have identified perceived injustice as an important risk factor for pain-related outcomes. Studies suggest that perceived injustice is associated with opioid prescription in patients with pain conditions. However, the mechanisms by which perceived injustice is linked to opioid prescription are not well understood...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28331357/effectiveness-of-ultrasound-therapy-for-myofascial-pain-syndrome-a-systematic-review-and-meta-analysis
#5
REVIEW
Peng Xia, Xiaoju Wang, Qiang Lin, Kai Cheng, Xueping Li
OBJECTIVE: The objective of this review was to assess the therapeutic effect of ultrasound (US) on myofascial pain syndrome (MPS). DATE SOURCES: PubMed, Embase, and Cochrane Library were searched to find relevant studies from January 1966 to May 2016 using keywords. Four investigators performed the data extraction. STUDY SELECTION: Randomized controlled trials (RCTs) investigating the outcomes of pain and physical function between MPS patients receiving and not receiving US were selected by two researchers independently...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28331356/individual-and-dyadic-coping-in-chronic-pain-patients
#6
Andrea Burri, Michèle Blank Gebre, Guy Bodenmann
The purpose of the current cross-sectional study was to test the associations between individual coping responses to pain, dyadic coping, and perceived social support, with a number of pain outcomes, including pain intensity, functional disability, and pain adjustment, in a sample of N = 43 patients suffering from chronic pain in Switzerland. In contrast to previous research, we were interested not only in specific pain coping but also in more general stress coping strategies and their potential influence on pain outcomes...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28331355/observing-continuous-change-in-heart-rate-variability-and-photoplethysmography-derived-parameters-during-the-process-of-pain-production-relief-with-thermal-stimuli
#7
Jing-Jhao Ye, Kuan-Ting Lee, Jing-Siang Lin, Chiung-Cheng Chuang
Continuously monitoring and efficiently managing pain has become an important issue. However, no study has investigated a change in physiological parameters during the process of pain production/relief. This study modeled the process of pain production/relief using ramped thermal stimulation (no pain: 37°C water, process of pain production: a heating rate of 1°C/min, and subject feels pain: water kept at the painful temperature for each subject, with each segment lasting 10 min). In this duration, the variation of the heat rate variability and photoplethysmography-derived parameters was observed...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28280384/tapentadol-extended-release-for-the-management-of-chronic-neck-pain
#8
Domenico Billeci, Flaminia Coluzzi
BACKGROUND: The role of opioids in the management of chronic neck pain is still poorly investigated. No data are available on tapentadol extended release (ER). In this article, we present 54 patients with moderate-to-severe chronic neck pain treated with tapentadol ER. PATIENTS AND METHODS: Patients received tapentadol ER 100 mg/day; dosage was then adjusted according to clinical needs. The following parameters were recorded: pain; Douleur Neuropathique 4 score; Neck Disability Index score; range of motion; pain-associated sleep interference; quality of life (Short Form [36] Health Survey); Patient Global Impression of Change (PGIC); Clinician GIC; opioid-related adverse effects; and need for other analgesics...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28280383/nurses-and-opioids-results-of-a-bi-national-survey-on-mental-models-regarding-opioid-administration-in-hospitals
#9
Charlotte Guest, Fabian Sobotka, Athina Karavasopoulou, Stephen Ward, Carsten Bantel
OBJECTIVE: Pain remains insufficiently treated in hospitals. Increasing evidence suggests human factors contribute to this, due to nurses failing to administer opioids. This behavior might be the consequence of nurses' mental models about opioids. As personal experience and conceptions shape these models, the aim of this prospective survey was to identify model-influencing factors. MATERIAL AND METHODS: A questionnaire was developed comprising of 14 statements concerning ideations about opioids and seven questions concerning demographics, indicators of adult learning, and strength of religious beliefs...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28280382/retention-of-finger-blood-flow-against-postural-change-as-an-indicator-of-successful-sympathetic-block-in-the-upper-limb
#10
Toshihiko Nakatani, Tatsuya Hashimoto, Ichiro Sutou, Yoji Saito
BACKGROUND: Sympathetic block in the upper limb has diagnostic, therapeutic and prognostic utility for disorders in the upper extremity that are associated with sympathetic disturbances. Increased skin temperature and decreased sweating are used to identify the adequacy of sympathetic block in the upper limb after stellate ganglion block (SGB). Baroreflexes elicited by postural change induce a reduction in peripheral blood flow by causing sympathetic vasoconstriction. We hypothesized that sympathetic block in the upper limb reduces the decrease in finger blood flow caused by baroreflexes stimulated by postural change from the supine to long sitting position...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28280381/topical-phenytoin-for-the-treatment-of-neuropathic-pain
#11
David J Kopsky, Jan M Keppel Hesselink
We developed and tested a new putative analgesic cream, based on the anticonvulsant phenytoin in patients suffering from treatment refractory neuropathic pain. The use of commercial topical analgesics is not widespread due to the facts that capsaicin creams or patches can give rise to side effects, such as burning, and analgesic patches (e.g., lidocaine 5% patches) have complex handling, especially for geriatric patients. Only in a few countries, compounded creams based on tricyclic antidepressants or other (co-)analgesics are available...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28280380/estimated-risk-for-chronic-pain-determined-using-the-generic-start-back-5-item-screening-tool
#12
Hiroyuki Oka, Ko Matsudaira, Tomoko Fujii, Norimasa Kikuchi, Yuri Haga, Takayuki Sawada, Junji Katsuhira, Takahiko Yoshimoto, Kayo Kawamata, Juichi Tonosu, Masahiko Sumitani, Satoshi Kasahara, Sakae Tanaka
OBJECTIVE: The generic STarT Back 5-item screening tool (STarT-G) is used to manage chronic pain in the lower back and elsewhere. This study evaluated the validity of the Japanese version of this generic screening tool. MATERIALS AND METHODS: Japanese participants between the ages of 20 and 64 years completed online surveys regarding pain. Survey reliability was assessed with internal consistency, as calculated using Cronbach's alpha coefficients. Spearman's correlation coefficients were used to evaluate concurrent validity between the STarT-G score and standard reference questionnaires...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28260944/a-famciclovir-celecoxib-combination-treatment-is-safe-and-efficacious-in-the-treatment-of-fibromyalgia
#13
William L Pridgen, Carol Duffy, Judy F Gendreau, R Michael Gendreau
OBJECTIVE: Infections and other stressors have been implicated in the development of fibromyalgia. We hypothesized that these stressors could result in recurrent reactivations of latent herpes virus infections, which could lead to the development of fibromyalgia. This study evaluated a famciclovir + celecoxib drug combination (IMC-1), active against suspected herpes virus reactivation and infection, for the treatment of fibromyalgia. METHODS: A total of 143 fibromyalgia patients were enrolled at 12 sites in a 16-week, double-blinded, placebo-controlled proof-of-concept trial...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28260943/efficacy-of-ondansetron-for-the-prevention-of-propofol-injection-pain-a-meta-analysis
#14
Shenglin Pei, Chengmao Zhou, Yu Zhu, Bing Huang
AIM: This review was performed to investigate the effect of ondansetron on the prevention of propofol injection pain. METHODS: PubMed, Cochrane Library, and China National Knowledge Infrastructure (CNKI) were searched for randomized controlled trials (RCTs) of ondansetron in preventing the pain on injection of propofol. Then, RevMan 5.2 was adopted to conduct a meta-analysis on propofol injection pain. RESULTS: Ten RCTs, totaling 782 patients, were included in this analysis...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28255254/ema401-an-old-antagonist-of-the-at2r-for-a-new-indication-in-neuropathic-pain
#15
Jan M Keppel Hesselink, Michael E Schatman
EMA401 is an old molecule, synthesized by Parke-Davis in the last century and characterized at that time as an AT2R antagonist. Professor Maree Smith and her group from the University of Queensland (Australia) patented the drug and many related derivatives and other compounds with high affinity for the AT2R for the indication neuropathic pain in 2004, an example of drug repositioning. After some years of university work, the Australian biotech company Spinifex Pharmaceuticals took over further research and development and characterized the S-enantiomer, code name EMA401, and related compounds in a variety of animal models for neuropathic and cancer pain...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28255253/a-case-report-of-complex-auricular-neuralgia-treated-with-the-great-auricular-nerve-and-facet-blocks
#16
Marzieh Eghtesadi, Elizabeth Leroux, Grisell Vargas-Schaffer
BACKGROUND: The great auricular nerve is a cutaneous branch of the cervical plexus originating from the C2 and C3 spinal nerves. It innervates the skin over the external ear, the angle of the mandible and the parotid gland. It communicates with the ansa cervicalis. Great auricular neuralgia is rarely diagnosed in clinical practice and can be refractory. We present a new approach using ultrasound-guided nerve blocks. CASE: We present a case of a 41-year-old female with paroxysmal ear pain accompanied by dysautonomia, tingling in the tongue, dysphagia, dysarthria and abdominal symptoms...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28243147/sex-specific-impact-of-early-life-adversity-on-chronic-pain-a-large-population-based-study-in-japan
#17
Keiko Yamada, Ko Matsudaira, Eizaburo Tanaka, Hiroyuki Oka, Junji Katsuhira, Hiroyasu Iso
BACKGROUND: Responses to early-life adversity may differ by sex. We investigated the sex-specific impact of early-life adversity on chronic pain, chronic multisite pain, and somatizing tendency with chronic pain. METHODS: We examined 4229 respondents aged 20-79 years who participated in the Pain Associated Cross-Sectional Epidemiological Survey in Japan. Outcomes were: 1) chronic pain prevalence, 2) multisite pain (≥3 sites) prevalence, and 3) multiple somatic symptoms (≥3 symptoms) among respondents with chronic pain related to the presence or absence of early-life adversity...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28243146/p2y12-receptor-mediated-activation-of-spinal-microglia-and-p38mapk-pathway-contribute-to-cancer-induced-bone-pain
#18
Mingjuan Liu, Ming Yao, Hanqi Wang, Longsheng Xu, Ying Zheng, Bing Huang, Huadong Ni, Shijie Xu, Xuyan Zhou, Qingquan Lian
BACKGROUND: Cancer-induced bone pain (CIBP) is one of the most challenging clinical problems due to a lack of understanding the mechanisms. Recent evidence has demonstrated that activation of microglial G-protein-coupled P2Y12 receptor (P2Y12R) and proinflammatory cytokine production play an important role in neuropathic pain generation and maintenance. However, whether P2Y12R is involved in CIBP remains unknown. METHODS: The purpose of this study was to investigate the role of P2Y12R in CIBP and its molecular mechanisms...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28243145/a-comparison-of-the-postoperative-analgesic-efficacy-between-epidural-and-intravenous-analgesia-in-major-spine-surgery-a-meta-analysis
#19
Yichen Meng, Heng Jiang, Chenglin Zhang, Jianquan Zhao, Ce Wang, Rui Gao, Xuhui Zhou
Postoperative analgesia remains a challenge for orthopedic surgeons. The aim of this meta-analysis is to compare the efficacy of epidural analgesia (EA) and intravenous patient-controlled analgesia (IV-PCA) following major spine surgery. We searched electronic databases, including the PubMed, EMBASE, Ovid and Cochrane databases, for randomized controlled trials (RCTs) published before June 2016. The quality of the included trials was assessed using the Cochrane risk-of-bias tool. Random effects models were used to estimate the standardized mean differences (SMDs) and relative risks (RRs), with the corresponding 95% confidence intervals (CI)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28243144/a-double-blind-randomized-comparative-study-of-the-use-of-a-combination-of-uridine-triphosphate-trisodium-cytidine-monophosphate-disodium-and-hydroxocobalamin-versus-isolated-treatment-with-hydroxocobalamin-in-patients-presenting-with-compressive-neuralgias
#20
Henrique Goldberg, Marco Antonio Mibielli, Carlos Pereira Nunes, Stephanie Wrobel Goldberg, Luiz Buchman, Spyros Ge Mezitis, Helio Rzetelna, Lisa Oliveira, Mauro Geller, Fernanda Wajnsztajn
CONTEXT: This paper reports on the results of treatment of compressive neuralgia using a combination of nucleotides (uridine triphosphate trisodium [UTP] and cytidine monophosphate disodium [CMP]) and vitamin B12. OBJECTIVES: To assess the safety and efficacy of the combination of nucleotides (UTP and CMP) and vitamin B12 in patients presenting with neuralgia arising from neural compression associated with degenerative orthopedic alterations and trauma, and to compare these effects with isolated administration of vitamin B12...
2017: Journal of Pain Research
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