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Journal of Pain Research

Jan M Keppel Hesselink, Michael E Schatman
The repurposing of old drugs for new indications is becoming more accepted as a cost-efficient solution for complicated health problems. However, older drugs are often forgotten when they are not repositioned. This analysis makes a case for re-exploration of dermorphin for intrathecal use in postoperative pain and in a palliative context, with the goal of re-establishing this compound. Dermorphin was isolated from the skin of an Amazonian frog, characterized and identified as a bioactive heptapeptide by Vittorio Erspamer's research group in the early 1980s...
2018: Journal of Pain Research
Nada Lukkahatai, Brian Walitt, Enrique J Deandrés-Galiana, Juan Luis Fernández-Martínez, Leorey N Saligan
Objectives: Fibromyalgia syndrome (FMS) is a chronic and often debilitating condition that is characterized by persistent fatigue, pain, bowel abnormalities, and sleep disturbances. Currently, there are no definitive prognostic or diagnostic biomarkers for FMS. This study attempted to utilize a novel predictive algorithm to identify a group of genes whose differential expression discriminated individuals with FMS diagnosis from healthy controls. Methods: Secondary analysis of gene expression data from 28 women with FMS and 19 age-and race-matched healthy women...
2018: Journal of Pain Research
Isabela Freire Azevedo-Santos, Josimari Melo DeSantana
Background: Procedural pain is a frequent problem in intensive care units (ICUs). For that, pain assessment has been increasingly introduced to the ICU professional's routine, and studies have been developed to show the relevance of measuring pain in critically ill patients. Objective: This review aimed to describe pain measurement techniques for mechanically ventilated adult patients based on evidence and already published. Method: Systematic literature search was performed on PubMed and Google Scholar...
2018: Journal of Pain Research
Sang Jun Park, Kyung Bong Yoon, Dong Ah Shin, Kiwook Kim, Tae Lim Kim, Shin Hyung Kim
Background: A caudal epidural steroid injection (CESI) is a commonly used method to improve symptoms of lumbosacral pain. We compared the achievement of successful epidurograms and patient-reported clinical outcomes following different needle-insertion depths during CESI. Methods: For the conventional method group, the needle was advanced into the sacral canal. For the alternative method group, the needle was positioned immediately after penetration of the sacrococcygeal ligament...
2018: Journal of Pain Research
Lourdes Biedma-Velázquez, María Isabel García-Rodríguez, Rafael Serrano-Del-Rosal
Background: Pain is a perception conditioned both by the painful experience and by each society's collective imagination. The general objective of the project which this work forms part of it was to discover what citizens think about different aspects of this complex experience. More precisely, this paper's objective is to get to know which is the worst pain that can be suffered according to Spaniards and what determines that hierarchy, bearing in mind that this work has chosen a broad definition of pain, including pains of different origins, namely, physical, psychological, and emotional pain...
2018: Journal of Pain Research
Pierce D Nunley, Timothy R Deer, Ramsin M Benyamin, Peter S Staats, Jon E Block
Background: Lumbar spinal stenosis (LSS) causes significant pain and functional impairment, and medical management has increasingly included the prescription of opioid-based analgesics. Interspinous process decompression (IPD) provides a minimally-invasive treatment option for LSS. Methods: This study estimated the type, dosage, and duration of opioid medications through 5 years of follow-up after IPD with the Superion Indirect Decompression System (Vertiflex Inc...
2018: Journal of Pain Research
David J DiBenedetto, Kelly M Wawrzyniak, Michael E Schatman, Ronald J Kulich, Matthew Finkelman
Objective: To evaluate clinical outcomes and health care utilization at 12 months post spinal cord stimulator (SCS) implantation compared with baseline and a matched sample of patients receiving conventional medical management (CMM) for the treatment of low back and lower extremity pain. Patients: A retrospective study of patients with at least 24 months of active treatment at an interdisciplinary community pain center between December 1, 2014 and December 31, 2017...
2018: Journal of Pain Research
Jannike Kaasbøll, Stian Lydersen, Ingunn Ranøyen, Wendy Nilsen, Marit S Indredavik
Background: A growing body of research suggests that the children of parents with chronic pain are at risk for internalizing symptoms. The mechanisms of such associations have not been as thoroughly examined. The aim of the present study was to investigate whether adolescents' social competence mediates the association between parental chronic pain and offspring internalizing symptoms as well as whether these associations are moderated by adolescent gender. Methods: The current study was based on cross-sectional data from the Nord-Trøndelag Health Study (HUNT 3), a Norwegian population-based health survey conducted in 2006-2008...
2018: Journal of Pain Research
Qi Chen, Xing Liu, Xuejiao Zhong, Bin Yang
Background: Transversus abdominis plane (TAP) block is reportedly a preferable technique for reducing postoperative pain in abdominal surgeries. The aim of this study was to compare the analgesic efficacy and recovery quality after gynecological surgery by adding dexmedetomidine or fentanyl into an ultrasound-guided TAP block. Methods: We randomly assigned 100 elective gynecological patients into four groups (TAP, TAP-DEX, TAP-FEN, and control, n=25 in each). TAP blocks were performed postoperatively...
2018: Journal of Pain Research
Toshiharu Azma, Akira Nishioka, Saori Ogawa, Hiroshi Nagasaka, Nobuyuki Matsumoto
Background: The enhanced expression of endogenous opioid peptides, including β-endorphin, has been implicated in the mechanism of action of pulsed radio frequency (PRF) application in pain modulation. Because thermal effects cannot be separated from the physical property of PRF application to biological tissues, we evaluated whether temperatures higher than that of the normal body temperature (37°C) modulate mRNA expression for the precursor of β-endorphin, proopiomelanocortin (POMC) in human monocytic cells THP-1...
2018: Journal of Pain Research
Ryousuke Nakajima, Airi Uehara, Shiori Takehana, Youichi Akama, Yoshihito Shimazu, Mamoru Takeda
Background: Acute application of decanoic acid (DA) in vivo suppresses the excitability of spinal trigeminal nucleus caudalis (SpVc) wide dynamic range (WDR) neurons associated with the short-term mechanical hypoalgesia via muscarinic M2 receptor signaling; however, the effect of DA on nociceptive trigeminal ganglion (TG) and SpVc nociceptive-specific (NS) neuronal excitability under in vivo conditions remains to be determined. The present study investigated whether this effect could be observed in naive rats...
2018: Journal of Pain Research
Baogan Peng, Michael J DePalma
Cervical intervertebral disc has long been considered a common source of neck pain. However, the pain caused by the disc itself has not been clearly defined so far, and its diagnosis and treatment has always been controversial. Degenerative cervical disc has a rich supply of nerve fibers, is prone to inflammatory reactions, and is susceptible to pain that can be provoked by disc stimulation or distention, and can be eliminated by block. Overwhelming clinical evidence demonstrates that neck pain in patients with degenerative cervical radiculopathy or myelopathy can be subsided rapidly by anterior cervical surgery, further indicating that this neck pain stems from the pathology of cervical disc itself...
2018: Journal of Pain Research
Yuzuru Takahashi, Takuya Tominaga, Kohei Okawa, Kohei Tanaka
Background: Complex regional pain syndrome type I (CRPS I) in children is a serious condition disrupting the family and school life of patients with the condition after it fully develops. It has been emphasized that early diagnosis is closely associated with earlier reduction of pain leading to preferable outcomes. Objectives: To report a case of acute CRPS I in a boy who was found to develop this condition by a routine visual analog scale (VAS) pain monitoring and who recovered from CRPS I at an early phase by prompt pharmacological, physical, and educational therapies...
2018: Journal of Pain Research
Jan M Keppel Hesselink, Michael E Schatman
No abstract text is available yet for this article.
2018: Journal of Pain Research
Camilla Wiwe Lipsker, Sven Bölte, Tatja Hirvikoski, Mats Lekander, Linda Holmström, Rikard K Wicksell
Purpose: Recent research has suggested that autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) may be comorbid to pediatric chronic pain, but the empirical support is yet scarce. Therefore, the current study aimed to investigate the occurrence of traits and symptoms consistent with clinically significant ASD and ADHD in a group of children and adolescents with chronic debilitating pain and examine potential differences in pain and demographic variables between children with and without clinically significant traits and symptoms of ASD and ADHD...
2018: Journal of Pain Research
H Y Zhong, X B Deng, Z Wang
Background: Postoperative agitation after general anesthesia is a common complication in children; however, pain or uncomfortable feeling is the main reason of emergence agitation. Here, we have investigated the effects of fascia iliaca compartment block (FICB) combined with general laryngeal mask airway (LMA) anesthesia in children undergoing femoral surgery. Methods: Eighty children undergoing femoral surgery were randomly divided into two groups: FICB + LMA group and control group (n=40)...
2018: Journal of Pain Research
David Charles Baranowski, Beth Buchanan, Heather C Dwyer, Joseph P Gabriele, Stephanie Kelly, Joseph A Araujo
Purpose: Prescription and OTC non-steroidal anti-inflammatory drugs (NSAIDs) are ubiquitous treatments for pain and inflammation; however, oral administration of these drugs may produce gastrointestinal (GI) side effects. Transdermal (TD) administration of NSAIDs circumvents these adverse events by avoiding the GI tract and, presumably, achieves regional drug levels of therapeutic effect and thereby, fewer off-target complications. Methods: A drug quantification method was developed for ibuprofen and celecoxib in canine plasma and synovial fluid using liquid chromatography and mass spectrometry...
2018: Journal of Pain Research
M Lv, P Zhang, Z Wang
Background: It was reported that epidural volume extension could decrease the ED50 of intrathecal plain bupivacaine. In this study, we investigated the ED50 of intrathecal hyperbaric ropivacaine followed by epidural normal saline bolus for cesarean section. Methods: Sixty parturients were allocated into two groups in this prospective study. About 10 mL of epidural normal saline was given after the intrathecal dose of hyperbaric ropivacaine in the Group S (normal saline group), and no epidural injection of normal saline was given after the intrathecal ropivacainve injection in the Group C (control group)...
2018: Journal of Pain Research
Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Leyla Sedighipour, Zeynab Bossaghzade, Mohamad Hesam Abdollahzadeh, Rojin Nikray, Fazeleh Mollayi
Introduction: The aim of this survey was to examine the effect of adding electromyographic biofeedback (EMGBF) to isometric exercise, on pain, function, thickness, and maximal electrical activity in isometric contraction of the vastus medialis oblique (VMO) muscle in patients with knee osteoarthritis (OA). Methods: In this clinical trial, 46 patients with a diagnosis of knee OA were recruited and assigned to two groups. The case group consisted of 23 patients with EMGBF-associated exercise, and the control group was made up of 23 patients with only isometric exercise...
2018: Journal of Pain Research
Robert K Twillman, Nicole Hemmenway, Steven D Passik, Christy A Thompson, Michael Shrum, Michael K DeGeorge
Background: In 2016, the Centers for Disease Control and Prevention (CDC) released a guideline on opioid prescribing for primary care physicians. Patients with chronic pain receiving long-term opioid therapy were surveyed to assess the incidence and impact of opioid dose reduction following this guideline's promulgation. Methods: Members of an advocacy organization for people with chronic pain were invited to participate in a 16-item, anonymous, online survey conducted in September/October 2017...
2018: Journal of Pain Research
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