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Journal of Pain Research

Wei Liu, Yuluo Rong, Jian Chen, Yongjun Luo, Pengyu Tang, Zheng Zhou, Jin Fan, Weihua Cai
Purpose: To explore the role of cervical sagittal alignment in the occurrence of adjacent-level ossification development (ALOD) in patients who underwent anterior cervical discectomy fusion with self-locking stand-alone polyetheretherketone cage, and the relationship between cervical sagittal alignment and clinical outcomes. Background: Because of its advantages, anterior cervical plating systems have been used as the classic surgical method in the treatment of patients with cervical disc herniation...
2018: Journal of Pain Research
Wangjun Qin, Botao Liu, Ang Deng, Ying Liu, Xianglin Zhang, Lei Zhang
Intrathecal morphine provides superior analgesia and minimizes side effects with ~1/300th of the oral dose necessary to achieve this effect. The conversion ratios from oral route to intrathecal route vary greatly among individuals, and this may be related with polymorphisms of the ATP-binding cassette B1 ( ABCB1 )/ multiple drug resistance 1 ( MDR1 ) gene encoding the transporter P-glycoprotein in the blood-brain barrier. In the case presented herein, a patient with cancer pain for over 3 months was treated with oxycodone hydrochloride prolonged-release tablets (Oxycontin) and morphine hydrochloride tablets for breakthrough pain...
2018: Journal of Pain Research
Andrew J Cook, David A Roberts, Karen C Nelson, Brian R Clark, B Eugene Parker
Background: Assessment of function and functional interference is an important component of chronic pain assessment and treatment and is commonly based on self-report questionnaires. Existing questionnaires for assessing functional interference are language dependent, which can limit their utility for patients across cultures with literacy, fluency, or cognitive restrictions. Objective: The objectives of this study were to create a tool with minimal language dependence and literacy requirement for measuring functional interference due to chronic pain and evaluate the psychometric properties and usability of this new assessment scale, the Pictorial Pain Interference Questionnaire (PPIQ), in a clinical sample of participants with chronic pain...
2018: Journal of Pain Research
Jiaming Zhou, Tengshuai Li, Liandong Li, Yuan Xue
Background: The objective of this study was to compare the efficacy of calcitonin with diclofenac sodium in the treatment of patients with nonspecific low back pain (LBP) and type I Modic changes (MC1). Patients and methods: The study was a retrospective observational study with 109 patients who had nonspecific LBP and MC1 that appeared as bone marrow lesions on magnetic resonance imaging (MRI). Between October 2013 and March 2016, 62 patients were injected intramuscularly with calcitonin 50 IU once daily and 47 patients were treated with diclofenac 75 mg once per day for 4 weeks for the treatment of LBP associated with MC1 on MRI...
2018: Journal of Pain Research
Reza Salman Roghani, Mohammad Taghi Holisaz, Ali Asghar Sahami Norouzi, Ahmad Delbari, Faeze Gohari, Johan Lokk, Andrea J Boon
Background: Suspecting carpal tunnel syndrome (CTS) in patients with hand pain is usual. Considering the variable rate of false-negative results in nerve conduction study (NCS), as a frequent reference confirmatory standard test, we aimed to evaluate the diagnostic accuracy of neuromuscular ultrasound in patients with clinical evidence of CTS and normal NCS. Methods: It was a diagnostic accuracy study conducted in the outpatient clinic of Rofaydeh Hospital, Tehran, Iran, between July 2012 and December 2016; it recruited clinically diagnosed CTS patients and a control group...
2018: Journal of Pain Research
Hans Timmerman, Oliver Hg Wilder-Smith, Monique Ah Steegers, Kris Cp Vissers, André P Wolff
Background: The assessment of a neuropathic pain component (NePC) to establish the neurological criteria required to comply with the clinical description is based on history taking, clinical examination, and quantitative sensory testing (QST) and includes bedside examination (BSE). The objective of this study was to assess the potential association between the clinically diagnosed presence or absence of an NePC, BSE, and the Nijmegen-Aalborg screening QST (NASQ) paradigm in patients with chronic (≥3 months) low back and leg pain or with neck shoulder arm pain or in patients with chronic pain due to suspected peripheral nerve damage...
2018: Journal of Pain Research
Giada Amodeo, Dario Bugada, Silvia Franchi, Giorgia Moschetti, Stefania Grimaldi, Alberto Panerai, Massimo Allegri, Paola Sacerdote
Introduction: Impaired immune function during the perioperative period may be associated with worse short- and long-term outcomes. Morphine is considered a major contributor to immune modulation. Patients and methods: We performed a pilot study to investigate postoperative immune function by analyzing peripheral blood mononuclear cells' functionality and cytokine production in 16 patients undergoing major abdominal surgery. All patients were treated with intravenous (i...
2018: Journal of Pain Research
Ozlem Kocaturk, Sultan Keles
Background: Pediatric dental procedures are performed under anesthesia because children may be uncooperative in the dental clinic due to their young age. Emergence delirium (ED), which involves a variety of behavioral disturbances that are frequently observed in children following emergence from general anesthesia, remains an unclear phenomenon. The aim of this randomized controlled trial is to compare the incidence of ED in children who underwent full mouth dental rehabilitation under either sevoflurane (SEVO) anesthesia or propofol-based total intravenous anesthesia (TIVA)...
2018: Journal of Pain Research
Ryckie G Wade, Claire B Paxman, Naomi C Tucker, Stephen Southern
Objectives: Osteoarthritis (OA) is the most common arthropathy of the hand, and current treatments carry risks of adverse events. Supportive (kinesiology) tape may be analgesic and provide functional improvement, with a low risk of adverse outcomes. We experimented with supportive tape for OA of the proximal interphalangeal joint (PIPJ) of the finger in this pilot randomized trial. Methods: This two-group parallel randomized trial recruited adults with OA of the PIPJ of the finger...
2018: Journal of Pain Research
Mei-Ling Sharon Tai, Jun Fai Yap, Cheng Beh Goh
Background: The literature on the dietary trigger factors of headache among the South East Asians is limited. Objective: The objective of the study was to examine the dietary trigger factors of migraine and tension-type headache (TTH) in Malaysian patients, consisting of Malays, Chinese and Indians. Methods: In this prospective cross-sectional study, patients presenting with migraine and TTH to a neurology clinic between April 2010 and June 2017 were recruited...
2018: Journal of Pain Research
Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Fatemeh Sadeghi, Shahram Rahimi-Dehgolan
Purpose: Myofascial pain syndrome (MPS) is a common musculoskeletal disorder among young adults associated with presence of myofascial trigger points. We aimed to evaluate efficacy of ozone injection (OI) in MPS patients, compared with two currently used methods including lidocaine injection (LI) and dry needling (DN). Patients and methods: In this single-blinded study, a total of 72 eligible patients were included and then randomly divided into three equal groups: DN, OI, and LI...
2018: Journal of Pain Research
Anne Söderlund, Lena Nordgren, Michele Sterling, Britt-Marie Stålnacke
Purpose: The aim of this study was to conduct a meta-synthesis to analyze qualitative research findings and thereby understand patients' experiences of whiplash-associated disorders (WAD) and the injury-recovery process. Materials and methods: A qualitative meta-synthesis, which is an interpretive integration of existing qualitative findings, was performed. The databases PubMed, PsychINFO, Scopus, and Web of Science were searched. The Critical Assessment Skills Programme was used to assess the quality of the included studies...
2018: Journal of Pain Research
Fu-Hai Ji, Dan Wang, Juan Zhang, Hua-Yue Liu, Ke Peng
Purpose: After a radical gastrectomy, patients may experience severe pain. Some studies have reported that the use of propofol significantly reduced postoperative pain, while others have argued that this effect was not significant. Thus, we aimed to assess whether anesthesia with propofol could help to reduce pain after an open radical gastrectomy procedure. Patients and methods: Sixty patients who were scheduled to undergo a laparotomy for radical gastrectomy were randomly assigned to either the propofol or sevoflurane group (n=30 each)...
2018: Journal of Pain Research
Nicoletta Cinone, Sara Letizia, Luigi Santoro, Michele Gravina, Loredana Amoruso, Franco Molteni, Maurizio Ranieri, Andrea Santamato
Introduction: Shoulder pain is one of the most common musculoskeletal diseases, and can be due to glenohumeral osteoarthritis, rotator cuff tear, impingement, tendinitis, adhesive capsulitis, and subacromial bursitis. Several therapies have been proposed, including steroids, nonsteroidal anti-inflammatory drugs, intra-articular injections, and physical therapies. Many published studies have reported on the employment of botulinum toxin type A (BoNT-A) to reduce pain in subjects with neurological and musculoskeletal diseases by inhibiting substance P release and other inflammatory factors...
2018: Journal of Pain Research
Liandong Li, Yawei Han, Tengshuai Li, Jiaming Zhou, Chao Sun, Yuan Xue
Background: Central cord syndrome (CCS) may be associated with severe neuropathic pain that often resists to conventional pain therapy regimens and affects the patients' quality of life (QoL) seriously. Current treatments for CCS-associated neuropathic pain have limited evidence of efficacy. This retrospective study was performed to present the effects of early treatment with methylprednisolone (MP) on acute neuropathic pain relief and the QoL in CCS patients. Patients and methods: Data were collected from the medical records of CCS patients who suffered from acute neuropathic pain with allodynia...
2018: Journal of Pain Research
Seon Ju Kim, Sang Jun Park, Duck Mi Yoon, Kyung Bong Yoon, Shin Hyung Kim
Background: Pulsed radiofrequency (RF) targeting the adjacent dorsal root ganglion (DRG) is one treatment option for lumbosacral radicular pain. However, the analgesic efficacy of this procedure is not always guaranteed. The aim of this retrospective study was to identify the predictors of the analgesic efficacy of pulsed DRG RF treatment in patients with chronic lumbosacral radicular pain. Methods: Patients who underwent pulsed DRG RF treatment from 2006 to 2017 at our clinic were enrolled...
2018: Journal of Pain Research
Robert Gordon Sorrell, Jamie Muhlenfeld, John Moffett, Gary Stevens, Steven Kesten
Background: The incidence of chronic postoperative pain following lumbar spinal surgery has increased with the overall increase in the prevalence of lumbar surgery. This study was conducted to evaluate the analgesic effectiveness of pulsed electromagnetic field (PEMF) therapy in subjects with persistent pain following lumbar surgery. Patients and methods: A randomized, double-blind, sham-controlled, multicenter study in 36 subjects with persistent low-back and/or radiating leg pain after lumbar surgery was conducted...
2018: Journal of Pain Research
Jishi Ye, Hong Yan, Zhongyuan Xia
Background: Activation of microglia participates in a wide range of pathophysiological processes in the central nervous system. Some studies reported that oxycodone (6-deoxy-7,8-dehydro-14-hydroxy-3-O-methyl-6oxomorphine) could inhibit the overactivation of glial cells in rats' spinal cords. In the present study, we observed the effect of oxycodone on inflammatory molecules and pathway in lipopolysaccharide (LPS)-stimulated primary microglia in rats. Materials and methods: Neonatal rats' primary microglia were exposed to various concentrations (25, 50, 100 ng/mL) of oxycodone for 1 h after LPS stimulation for 24 h...
2018: Journal of Pain Research
Simona Capossela, David Pavlicek, Alessandro Bertolo, Gunther Landmann, Jivko V Stoyanov
Introduction: Chronic back pain is one of the most important socioeconomic problems that affects the global population. Elevated levels of inflammatory mediators, such as cytokines, have been correlated with pain, but their role in chronic back pain remains unclear. The effectiveness of anti-inflammatory drugs seems to be limited for chronic back pain. The authors wanted to investigate the levels of inflammatory mediators in long-term medically treated patients with persistent chronic back pain...
2018: Journal of Pain Research
Malte Baldewig, Olaf Goldbaum, Christiane Richter-Landsberg, Andreas Weyland, Carsten Bantel
Purpose: Gabapentinoids are currently the mainstay of pharmacological treatments for patients with neuropathic pain. Little is known about the effects of this therapy on the integrity of neuronal networks, especially in patients with an already-damaged nervous system. Since gabapentinoids can worsen cognitive functions and recent studies have shown alterations in the brains of patients with neuropathic pain, it may be possible that these drugs have neurotoxic effects. Methods: Rat clonal PC12 pheochromocytoma (autonomic) and primary sensory dorsal-root ganglion (DRG) neurons from newborn Wistar rats were employed for this study...
2018: Journal of Pain Research
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