Ali Hussein Mer, Yousef Mirzaei, Fatemeh Misamogooe, Nader Bagheri, Ahmadreza Bazyari, Zahra Keshtkaran, Anna Meyfour, Alireza Shahedi, Zahra Amirkhani, Ameneh Jafari, Nesa Barpour, Saeed Jahandideh, Behzad Rezaei, Yousef Nikmanesh, Meghdad Abdollahpour-Alitappeh
The cell-surface receptor tyrosine kinase c-mesenchymal-epithelial transition factor (c-Met) is overexpressed in a wide range of solid tumors, making it an appropriate target antigen for the development of anticancer therapeutics. Various antitumor c-Met-targeting therapies (including monoclonal antibodies [mAbs] and tyrosine kinases) have been developed for the treatment of c-Met-overexpressing tumors, most of which have so far failed to enter the clinic because of their efficacy and complications. Antibody-drug conjugates (ADCs), a new emerging class of cancer therapeutic agents that harness the target specificity of mAbs to deliver highly potent small molecules to the tumor with the minimal damage to normal cells, could be an attractive therapeutic approach to circumvent these limitations in patients with c-Met-overexpressing tumors...
April 10, 2024: Drug Delivery and Translational Research