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Drug Delivery and Translational Research

Liliana Gil-Cifuentes, Ronald A Jiménez, Marta R Fontanilla
Research on collagen type I scaffolds with Aloe vera is sparse. The aim of this work was to develop collagen type I scaffolds with gelatin-collagen microparticles and loaded with a dispersion of A. vera, to assess their performance as grafting material for healing of skin wounds. Scaffolds were evaluated in a Cavia porcellus model with full-thickness skin wound and compared with wounds healed by secondary intention (controls). Animals grafted with scaffolds without A. vera and their control wounds were also included in the study...
November 1, 2018: Drug Delivery and Translational Research
Stalielson Tatenda Ndlovu, Naseem Ullah, Shahzeb Khan, Pritika Ramharack, Mahmoud Soliman, Marcel de Matas, Muhammad Shahid, Muhammad Sohail, Muhammad Imran, Syed Wadood Ali Shah, Zahid Hussain
The aim of this study was to employ experimental and molecular modelling approaches to use molecular level interactions to rationalise the selection of suitable polymers for use in the production of stable domperidone (DOMP) nanocrystals with enhanced bioavailability. A low-energy antisolvent precipitation method was used for the preparation and screening of polymers for stable nanocrystals of DOMP. Ethyl cellulose was found to be very efficient in producing stable DOMP nanocrystals with particle size of 130 ± 3 nm...
November 1, 2018: Drug Delivery and Translational Research
Yuqing Su, Mengyang Liu, Yan Xiong, Junqiang Ding, Xinrong Liu, Yanzhi Song, Yihui Deng
Accelerated blood clearance (ABC) is a phenomenon where the blood clearance rate of the carrier system is substantially raised. It can be induced by repetitive injections of polyethylene glycol (PEG) (molecular weight 2000)-modified micelles (PM2000). To determine whether the PEG chain length and PEGylated micelle injection dose can have an effect on the ABC phenomenon, micelles were modified with PEGs of varying molecular weights; PEGs with molecular weights of 350, 550, 2000, 5000, 10,000, and 20,000 were used to generate the PEGylated micelles PM350, PM550, PM2000, PM10000, and PM20000, respectively...
October 30, 2018: Drug Delivery and Translational Research
Hangping Chen, Biyuan Wu, Minmin Zhang, Peipei Yang, Beibei Yang, Wanbing Qin, Qingqing Wang, Xinguo Wen, Meiwan Chen, Guilan Quan, Xin Pan, Chuanbin Wu
Microneedle arrays have emerged as an alternative method for transdermal drug delivery. Although micromolding using a centrifugation method is widely used to prepare microneedles in laboratory, few researchers were focused on manufacturing processes capable of facile scale-up. A novel female mold was initially designed in this study, namely double-penetration female mold (DPFM) with the pinpoints covered by waterproof breather membrane which was beneficial to reduce the influence of gas resistance and solution viscosity...
October 19, 2018: Drug Delivery and Translational Research
Samia Rebouh, Sonia Lefnaoui, Mounir Bouhedda, Madiha M Yahoum, Salah Hanini
In the present study, we investigated the drug release behavior from cellulose derivative (CD) matrices in the oral form of tablets. We used the adaptive neural-fuzzy inference system (ANFIS) to predict the best formulation parameters to get the perfect sustained drug delivery using ibuprofen (IB) as a model drug. The different formulations were prepared with different CDs, namely CMC, HEC, HPC, HPMC, and MC. The amount of the active ingredient varied between 20 and 50%. The flow properties of the powder mixtures were evaluated for their angle of repose, compressibility index, and Hausner ratio, while the tablets were evaluated for weight uniformity, hardness, friability, drug content, disintegration time, and release ratio...
October 19, 2018: Drug Delivery and Translational Research
Li Wang, Baolin Wang, Zeeshan Ahmad, Jing-Song Li, Ming-Wei Chang
In this study, a dual rotation centrifugal electrospinning system (DRCES) is designed, developed, and used to prepare medicated fabrics. Through simultaneous rotation of both spinneret and collector, multi-directional blended fiber matrices (PVP and TPU) were deposited directly on the rotating collector. To detail the process, key stages of the centrifugal electrospinning process are elaborated, and the influence of gas infusion and collector rotation speed on resulting fiber morphologies was explored. Multi-directional fibrous structures show in vitro biocompatibility (fibroblast)...
October 19, 2018: Drug Delivery and Translational Research
Mahsa Sedighi, Sandro Sieber, Fereshteh Rahimi, Mohammad-Ali Shahbazi, Ali Hossein Rezayan, Jörg Huwyler, Dominik Witzigmann
Liposomes have attracted much attention as the first nanoformulations entering the clinic. The optimization of physicochemical properties of liposomes during nanomedicine development however is time-consuming and challenging despite great advances in formulation development. Here, we present a systematic approach for the rapid size optimization of liposomes. The combination of microfluidics with a design-of-experiment (DoE) approach offers a strategy to rapidly screen and optimize various liposome formulations, i...
October 10, 2018: Drug Delivery and Translational Research
Arunkumar Ranganathan, Yuki Manabe, Tatsuya Sugawara, Takashi Hirata, Naveen Shivanna, Vallikannan Baskaran
Lutein has various biological activities, its application in food and pharma industries are limited due to poor aqueous solubility, stability, and bioavailability. To achieve various benefits, lutein-poly (lactic-co-glycolic acid) (PLGA)-phospholipid (PL) nanocapsules were prepared. Lutein-PLGA NCs (+PL) were synthesized, characterized and its bioavailability was studied in vitro and in vivo. The cellular uptake and anti-proliferative activity were analyzed in Hep G2 cells. The mean size and zeta value of lutein-PLGA NCs (+PL) were 140 ± 6 nm and - 44 mV...
October 3, 2018: Drug Delivery and Translational Research
Durga M S H Chandrupatla, Carla F M Molthoff, Adriaan A Lammertsma, Conny J van der Laken, Gerrit Jansen
Macrophages play a key role in the pathophysiology of rheumatoid arthritis (RA). Notably, positive correlations have been reported between synovial macrophage infiltration and disease activity as well as therapy outcome in RA patients. Hence, macrophages can serve as an important target for both imaging disease activity and drug delivery in RA. Folate receptor β (FRβ) is a glycosylphosphatidyl (GPI)-anchored plasma membrane protein being expressed on myeloid cells and activated macrophages. FRβ harbors a nanomolar binding affinity for folic acid allowing this receptor to be exploited for RA disease imaging (e...
October 2, 2018: Drug Delivery and Translational Research
Thi-Tram Nguyen, Eun-Jin Yi, Kyu-Mok Hwang, Cheol-Hee Cho, Chun-Woong Park, Ju-Young Kim, Yun-Seok Rhee, Eun-Seok Park
Pulmonary delivery of sildenafil for the treatment of pulmonary arterial hypertension could overcome the limitations of intravenous and oral administration routes, such as poor patient compliance and systemic side effects. In this study, a carrier-free dry powder inhaler (DPI) formulation was developed, using spray drying technique and L-leucine as a dispersibility enhancer. Sildenafil citrate salt and sildenafil free base were evaluated for drug transport using a Calu-3 cell model, and their suitability for DPI production by spray drying was tested...
October 1, 2018: Drug Delivery and Translational Research
Agustina García, Josefina Priotti, Ana Victoria Codina, María Delia Vasconi, Ariel D Quiroga, Lucila I Hinrichsen, Dario Leonardi, María Celina Lamas
This work aimed to synthesize a novel β-cyclodextrin derivative, itaconyl-β-cyclodextrin to evaluate whether albendazole inclusion complexes with the new β-cyclodextrin derivative-improved albendazole dissolution efficiency and its anthelminthic activity. The new derivative was thoroughly evaluated and characterized, and an average degree of substitution of 1.4 per cyclodextrin molecule was observed. Albendazole:itaconyl-β-cyclodextrin complexes were prepared by spray drying procedures and investigated using phase solubility diagrams, dissolution efficiency, X-ray diffraction, differential scanning calorimetry, Fourier transform infrared, scanning electronic microscopy, mass spectrometry, and nuclear magnetic resonance spectroscopy...
September 28, 2018: Drug Delivery and Translational Research
Phillip Dixon, Tanushri Ghosh, Kalyani Mondal, Aditya Konar, Anuj Chauhan, Sarbani Hazra
In the original article the typesetter made several errors. Figures 7 and 9 are incorrect. Following are the correct figures.
September 22, 2018: Drug Delivery and Translational Research
Martina Albini, Massimo Salvi, Emiliano Altamura, Simone Dinarelli, Loreto Di Donato, Andrea Lucibello, Fabio Mavelli, Filippo Molinari, Umberto Morbiducci, Alfonsina Ramundo-Orlando
Superparamagnetic iron oxide nanoparticles are used in a rapidly expanding number of research and practical applications in biotechnology and biomedicine. Recent developments in iron oxide nanoparticle design and understanding of nanoparticle membrane interactions have led to applications in magnetically triggered, liposome delivery vehicles with controlled structure. Here we study the effect of external physical stimuli-such as millimeter wave radiation-on the induced movement of giant lipid vesicles in suspension containing or not containing iron oxide maghemite (γ-Fe2 O3 ) nanoparticles (MNPs)...
September 10, 2018: Drug Delivery and Translational Research
Miglė Paškevičiūtė, Vilma Petrikaitė
Multidrug resistance (MDR) is a complex phenomenon caused by numerous reasons in cancer chemotherapy. It is related to the abnormal tumor metabolism, precisely increased glycolysis and lactic acid production, extracellular acidification, and drug efflux caused by transport proteins. There are few strategies to increase drug delivery into cancer cells. One of them is the inhibition of carbonic anhydrases or certain proton transporters that increase extracellular acidity by proton extrusion from the cells. This prevents weakly basic chemotherapeutic drugs from ionization and increases their penetration through the cancer cell membrane...
September 7, 2018: Drug Delivery and Translational Research
Shirleide Santos Nunes, Renata Salgado Fernandes, Carolina Henriques Cavalcante, Isabela da Costa César, Elaine Amaral Leite, Sávia Caldeira Araújo Lopes, Alice Ferretti, Domenico Rubello, Danyelle M Townsend, Mônica Cristina de Oliveira, Valbert Nascimento Cardoso, André Luís Branco de Barros
Liposomes are lipid vesicles widely used as nanocarriers in targeted drug delivery systems for therapeutic and/or diagnostic purposes. A strategy to prolong the blood circulation time of the liposomes includes the addition of a hydrophilic polymer polyethylene glycol (PEG) moiety onto the surface of the vesicle. Several studies claim that liposome PEGylation by a single chain length or a combination of PEG with different chain lengths may alter the liposomes' pharmacokinetic properties. Therefore, the purpose of this study was to evaluate the influence of PEG on the biodistribution of pH-sensitive liposomes in a tumor-bearing animal model...
September 5, 2018: Drug Delivery and Translational Research
Linlin Miao, Yuheng Liang, Wenli Pan, Jingxin Gou, Tian Yin, Yu Zhang, Haibing He, Xing Tang
The aim of the present investigation was to evaluate the effect of supersaturation on the oral absorption of paclitaxel (PTX) in vivo. To achieve this, a PTX amorphous solid dispersion (ASD) was prepared by the solvent cast method. Among the enteric polymers tested, hypromellose acetate succinate (HPMCAS) MF was found to be the most suitable polymer for maintaining PTX supersaturation and inhibiting crystallization in vitro. The dissolution rate and extent of the ASD was remarkably improved compared with a physical mixture (PM) of PTX, HPMCAS-MF, and Poloxamer 188 (F68), reaching an apparent drug concentration of 25-30 μg/mL and maintaining it for more than 2 h...
September 5, 2018: Drug Delivery and Translational Research
M R Fontanilla, S Casadiegos, R H Bustos, M A Patarroyo
In the original article text presenting and discussing results shown in Fig. 6 omitted to mention that quantification of TGF-β2 and TGF-β3 was not included in Fig. 6a, c, e.
September 5, 2018: Drug Delivery and Translational Research
Edward Helal-Neto, Suyene Rocha Pinto, Filipe Leal Portilho, Marcellus Dias da Costa, Jonathas Xavier Pereira, Fiammetta Nigro, Eduardo Ricci-Junior, Andre Luis Peixoto Candéa, Maria das Graças Muller de Oliveira Henriques, Ralph Santos-Oliveira
In this study, we developed, characterized, and tested in vivo polymeric nanoparticle of ethambutol labeled with 99mTc as nanoradiopharmaceutical for early diagnosis of tuberculosis by single-photon emission computed tomography, also as a therapeutic choice. Nanoparticles were developed by double emulsification. All characterization tests were performed, as scanning electron microscopy and dynamic light scattering. The labeling process with 99mTc was performed using the direct labeling process. In vitro and in vivo assays were performed with animals and cells...
September 3, 2018: Drug Delivery and Translational Research
Poonam Parashar, Chandra Bhushan Tripathi, Malti Arya, Jovita Kanoujia, Mahendra Singh, Abhishek Yadav, Shubhini A Saraf
Lung carcinoma ranks highest in cancer-related death (about 20% of total cancer deaths) due to poor prognosis and lack of efficient management therapy. Owing to the lack of effective therapeutic approaches, survival rate of less than 5 years persists over the years among non-small cell lung cancer (NSCLC) patients. Capsaicin (CAP) is well reported for its antiproliferative and antioxidant properties in various literature but lacks an appropriate delivery carrier. The present study was aimed to develop CAP-loaded hyaluronic acid (HA) nanoparticles (NPs) utilizing layer by layer technique to achieve enhanced and precise delivery as well as target specificity...
September 3, 2018: Drug Delivery and Translational Research
Mingyue Gao, Dan Mei, Yingnan Huo, Shirui Mao
Drug delivery to the brain is limited by the blood-brain barrier (BBB). Intranasal delivery is a non-invasive route of drug administration which can bypass the BBB and contributed to a direct and rapid transport of drugs to the brain. However, intrinsic drug distribution to the brain after intranasal administration may not be sufficient to achieve required clinical efficacy. In this study, taking 2,3,5,6-tetramethylpyrazine (TMPP) as a model drug, the feasibility of using polysorbate 80 as an absorption enhancer and message guider to increase drug distribution in the brain was employed...
August 30, 2018: Drug Delivery and Translational Research
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