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Drug Delivery and Translational Research

Martina Albini, Massimo Salvi, Emiliano Altamura, Simone Dinarelli, Loreto Di Donato, Andrea Lucibello, Fabio Mavelli, Filippo Molinari, Umberto Morbiducci, Alfonsina Ramundo-Orlando
Superparamagnetic iron oxide nanoparticles are used in a rapidly expanding number of research and practical applications in biotechnology and biomedicine. Recent developments in iron oxide nanoparticle design and understanding of nanoparticle membrane interactions have led to applications in magnetically triggered, liposome delivery vehicles with controlled structure. Here we study the effect of external physical stimuli-such as millimeter wave radiation-on the induced movement of giant lipid vesicles in suspension containing or not containing iron oxide maghemite (γ-Fe2 O3 ) nanoparticles (MNPs)...
September 10, 2018: Drug Delivery and Translational Research
Miglė Paškevičiūtė, Vilma Petrikaitė
Multidrug resistance (MDR) is a complex phenomenon caused by numerous reasons in cancer chemotherapy. It is related to the abnormal tumor metabolism, precisely increased glycolysis and lactic acid production, extracellular acidification, and drug efflux caused by transport proteins. There are few strategies to increase drug delivery into cancer cells. One of them is the inhibition of carbonic anhydrases or certain proton transporters that increase extracellular acidity by proton extrusion from the cells. This prevents weakly basic chemotherapeutic drugs from ionization and increases their penetration through the cancer cell membrane...
September 7, 2018: Drug Delivery and Translational Research
Shirleide Santos Nunes, Renata Salgado Fernandes, Carolina Henriques Cavalcante, Isabela da Costa César, Elaine Amaral Leite, Sávia Caldeira Araújo Lopes, Alice Ferretti, Domenico Rubello, Danyelle M Townsend, Mônica Cristina de Oliveira, Valbert Nascimento Cardoso, André Luís Branco de Barros
Liposomes are lipid vesicles widely used as nanocarriers in targeted drug delivery systems for therapeutic and/or diagnostic purposes. A strategy to prolong the blood circulation time of the liposomes includes the addition of a hydrophilic polymer polyethylene glycol (PEG) moiety onto the surface of the vesicle. Several studies claim that liposome PEGylation by a single chain length or a combination of PEG with different chain lengths may alter the liposomes' pharmacokinetic properties. Therefore, the purpose of this study was to evaluate the influence of PEG on the biodistribution of pH-sensitive liposomes in a tumor-bearing animal model...
September 5, 2018: Drug Delivery and Translational Research
Linlin Miao, Yuheng Liang, Wenli Pan, Jingxin Gou, Tian Yin, Yu Zhang, Haibing He, Xing Tang
The aim of the present investigation was to evaluate the effect of supersaturation on the oral absorption of paclitaxel (PTX) in vivo. To achieve this, a PTX amorphous solid dispersion (ASD) was prepared by the solvent cast method. Among the enteric polymers tested, hypromellose acetate succinate (HPMCAS) MF was found to be the most suitable polymer for maintaining PTX supersaturation and inhibiting crystallization in vitro. The dissolution rate and extent of the ASD was remarkably improved compared with a physical mixture (PM) of PTX, HPMCAS-MF, and Poloxamer 188 (F68), reaching an apparent drug concentration of 25-30 μg/mL and maintaining it for more than 2 h...
September 5, 2018: Drug Delivery and Translational Research
M R Fontanilla, S Casadiegos, R H Bustos, M A Patarroyo
In the original article text presenting and discussing results shown in Fig. 6 omitted to mention that quantification of TGF-β2 and TGF-β3 was not included in Fig. 6a, c, e.
September 5, 2018: Drug Delivery and Translational Research
Edward Helal-Neto, Suyene Rocha Pinto, Filipe Leal Portilho, Marcellus Dias da Costa, Jonathas Xavier Pereira, Fiammetta Nigro, Eduardo Ricci-Junior, Andre Luis Peixoto Candéa, Maria das Graças Muller de Oliveira Henriques, Ralph Santos-Oliveira
In this study, we developed, characterized, and tested in vivo polymeric nanoparticle of ethambutol labeled with 99mTc as nanoradiopharmaceutical for early diagnosis of tuberculosis by single-photon emission computed tomography, also as a therapeutic choice. Nanoparticles were developed by double emulsification. All characterization tests were performed, as scanning electron microscopy and dynamic light scattering. The labeling process with 99mTc was performed using the direct labeling process. In vitro and in vivo assays were performed with animals and cells...
September 3, 2018: Drug Delivery and Translational Research
Poonam Parashar, Chandra Bhushan Tripathi, Malti Arya, Jovita Kanoujia, Mahendra Singh, Abhishek Yadav, Shubhini A Saraf
Lung carcinoma ranks highest in cancer-related death (about 20% of total cancer deaths) due to poor prognosis and lack of efficient management therapy. Owing to the lack of effective therapeutic approaches, survival rate of less than 5 years persists over the years among non-small cell lung cancer (NSCLC) patients. Capsaicin (CAP) is well reported for its antiproliferative and antioxidant properties in various literature but lacks an appropriate delivery carrier. The present study was aimed to develop CAP-loaded hyaluronic acid (HA) nanoparticles (NPs) utilizing layer by layer technique to achieve enhanced and precise delivery as well as target specificity...
September 3, 2018: Drug Delivery and Translational Research
Mingyue Gao, Dan Mei, Yingnan Huo, Shirui Mao
Drug delivery to the brain is limited by the blood-brain barrier (BBB). Intranasal delivery is a non-invasive route of drug administration which can bypass the BBB and contributed to a direct and rapid transport of drugs to the brain. However, intrinsic drug distribution to the brain after intranasal administration may not be sufficient to achieve required clinical efficacy. In this study, taking 2,3,5,6-tetramethylpyrazine (TMPP) as a model drug, the feasibility of using polysorbate 80 as an absorption enhancer and message guider to increase drug distribution in the brain was employed...
August 30, 2018: Drug Delivery and Translational Research
Zhenyou Zou, Qiqiong Shen, Yanxia Pang, Xin Li, Yongfeng Chen, Xinjuan Wang, Xinhua Luo, Zhongmin Wu, Zhaosheng Bao, Juanli Zhang, Jiawei Liang, Lingjia Kong, Lunan Yan, Lijun Xiong, Tianjun Zhu, Shuaibin Yuan, Miaoyang Wang, Kewei Cai, Yinning Yao, Jianchao Wu, Yuding Jiang, Heng Liu, Jing Liu, Yan Zhou, Qianqian Dong, Wei Wang, Kangjie Zhu, Li Li, Yingjie Lou, Hongdian Wang, Yizi Li, Hong Lin
Alzheimer's disease (AD) is currently incurable and places a large burden on the caregivers of AD patients. In the AD brain, iron is abundant, catalyzing free radicals and impairing neurons. The blood-brain barrier hampers antidementia drug delivery via circulation to the brain, which limits the therapeutic effects of drugs. Here, according to the method described by Gobinda, we synthesized a 16 lysine (K) residue-linked low-density lipoprotein receptor-related protein (LRP)-binding amino acid segment of apolipoprotein E (K16APoE)...
August 22, 2018: Drug Delivery and Translational Research
Jasmin Monpara, Divya Velga, Tripti Verma, Sanjay Gupta, Pradeep Vavia
The aims of the research work were to synthesize ethyl(cholesteryl carbamoyl)-L-arginate (ECCA), an arginine-conjugated cholesterol derivative, and to evaluate its application as a gene delivery vector. The interactions of ECCA with DNA duplex were studied using molecular dynamics (MD) simulations. It was found that the guanidine group of ECCA could interact with the phosphate group of DNA through ionic interactions as well as hydrogen bonds. The structure of DNA was stable throughout the simulation time. Liposomes were formulated using ECCA and soya phosphatidylcholine (SPC) by a thin-film hydration method...
August 21, 2018: Drug Delivery and Translational Research
Mohammed Maniruzzaman, Ali Nokhodchi, Robert O Williams
No abstract text is available yet for this article.
July 5, 2018: Drug Delivery and Translational Research
Riyadh B Al Asady, Mike J Hounslow, Agba D Salman
Understanding the compaction behaviour of the primary powder in the roller compaction process is necessary to be able to better control the quality of the product. In this study, the plastic deformation of the primary particles was evaluated by determining two mechanical properties: the nano-indentation hardness and the viscoelasticity of the primary powder. The nano-indentation hardness of eight different materials with a wide range of mechanical properties was determined by indenting the surface of the single primary particle, whereas the viscoelasticity was evaluated for a powder bed using the creep test...
June 26, 2018: Drug Delivery and Translational Research
Maryam Naseroleslami, Nahid Aboutaleb, Kazem Parivar
Migration of stem cells after transplantation reduces their therapeutic effects. In this study, we hypothesized that superparamagnetic iron oxide nanoparticles (SPION)-labeled mesenchymal stem cells (MSCs) in the presence of magnetic field may have a capability to increase regenerative ability after heart failure (HF). A rat model of ISO (isoproterenol)-HF was established to investigate the effects of SPION-labeled MSCs on tissue regeneration in the presence and absence of magnetic field. Hydrodynamic size, shape, and formation of chemical bonds between SPION and polyethylene glycol (PEG) were measured using dynamic light scattering (DLS), transmission electron microscopy (TEM), and Fourier-transform infrared spectroscopy (FTIR)...
October 2018: Drug Delivery and Translational Research
K Laxmi Swetha, Aniruddha Roy
After the discovery of the enhanced permeability and retention effect in 1986, it was envisioned that nanoparticle-mediated tumor-targeted delivery of chemotherapeutics would make a radical change in cancer therapy. However, after three decades of extensive research, only a few nanotherapeutics have been approved for clinical use. Although significant advantages of nanomedicines have been demonstrated in pre-clinical studies, clinical outcome was found to be variable. Advanced research has revealed that significant biochemical and structural variations exist between (and among) different tumors...
October 2018: Drug Delivery and Translational Research
Ankit Parikh, Krishna Kathawala, Jintao Li, Chi Chen, Zhengnan Shan, Xia Cao, Xin-Fu Zhou, Sanjay Garg
Curcumin (CUR), a natural polyphenolic compound, is considered as one of the most potential candidates against Alzheimer disease (AD) by targeting multiple pathologies such as amyloid-beta, tau phosphorylation, and oxidative stress. Poor physicochemical profile and oral bioavailability (BA) are the major contributors to its failure in clinical trials. Lack of success in numerous drug clinical trials for the treatment of AD urges the need of repositioning of CUR. To overcome its limitation and enhance oral BA, Novel CUR Formulation (NCF) was developed using self-nanomicellizing solid dispersion strategy which displayed 117-fold enhancement in oral BA of CUR...
October 2018: Drug Delivery and Translational Research
Luciana Damacena Silva, Nayana Ferreira Lima, Eva Carolina Arrua, Claudio Javier Salomon, Marina Clare Vinaud
Neurocysticercosis is the most common parasitic infection of the nervous system and currently represents a serious public health issue in many regions of Latin America, Asia, and Africa. To date, praziquantel is one of the chosen drugs for the treatment of neurocysticercosis. Its mechanism of action is based on the inhibition of different biochemical pathways within the parasite which contribute to its death. Thus, the aim of this work was to analyze, for the first time, whether the nanoformulations of praziquantel would modify the energetic pathway of Taenia crassiceps cysticerci, after an intracranial inoculation in BALB/c mice...
October 2018: Drug Delivery and Translational Research
Ying Huang, Zhengwei Huang, Xuejuan Zhang, Ziyu Zhao, Xuan Zhang, Kexin Wang, Cheng Ma, Chune Zhu, Xin Pan, Chuanbin Wu
Suitable nanometer roughness favors interactions between drugs and carriers, and it is a promising approach to enhance the aerosolization performance of carrier-based dry powder inhalers (DPIs). In this study, by altering the molecular migration rates, chitosan-based binary carriers (CBBCs) with nanometer roughness were fabricated for DPIs. Comprehensive physicochemical characterizations were conducted to elucidate the formation mechanism of the CBBCs. It was hypothesized that different constituent ratios in the formulations would result in different assembling of the particles and diverse roughness scales...
October 2018: Drug Delivery and Translational Research
Su-Yu Tang, Shun-Wen Zhang, Jie Zhang, Jiang-Tao Dong, Jiang-Dong Wu, Peng Guo, Jun-Ting Yang, Wan-Jiang Zhang, Fang Wu
To investigate the effect of early fluid resuscitation on intestinal microecology in rats with severe sepsis. The severe sepsis model used was mainly cecal ligation perforation (CLP) model. Male SD rats were randomly divided into five groups: sham, CLP, CLP + normal saline (NS), CLP + cyclophosphamide (CTX), and CLP + NS + CTX. (1) The levels of IL-6, IL-10, and TNF-α in peripheral blood were measured by ELISA. (2) The expression of occludin/β-action in colonic tissue of mice was examined by Western Blot...
October 2018: Drug Delivery and Translational Research
Elisabet Segredo-Morales, Ricardo Reyes, María Rosa Arnau, Araceli Delgado, Carmen Évora
The aim of this study was to evaluate the bone regeneration capacity of a Pluronic® F127 (P)-Tetronic®1307 (T) and α-cyclodextrin (CD) supramolecular gel (P-T-CD) in a 11/7/7 ratio containing BMP-2 and 17β-estradiol pre-encapsulated in poly-lactide-co-glycolide (PLGA) and poly-lactic acid (PLA-S) microspheres, respectively. Ovariectomy combined with dexamethasone treatment was used to induce an osteoporotic (OP) animal model of calvaria critical size defect in female rats to test the system. The two active substances showed a biphasic in vitro release profile characterized by an initial fast phase followed by a slow and prolonged release...
October 2018: Drug Delivery and Translational Research
Jean-Christophe Veilleux, Joseph E Shepherd
Spring-actuated autoinjectors delivering viscous drug solutions resulting from large drug concentrations require large spring forces which can create high peak pressures and stresses within syringes. The high peak pressures and stresses can lead to device failure. Measurements with a suite of novel instrumentation and analysis using numerical simulation explain the peak pressures and peak stresses as originating from mechanical impacts between moving components, the large acceleration of the components, and surprisingly, the production of tension waves in the liquid resulting in cavitation...
October 2018: Drug Delivery and Translational Research
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