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Drug Delivery and Translational Research

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https://www.readbyqxmd.com/read/28721611/bone-targeting-parathyroid-hormone-conjugates-outperform-unmodified-pth-in-the-anabolic-treatment-of-osteoporosis-in-rats
#1
Yang Yang, Ali Aghazadeh-Habashi, Arash Panahifar, Yuchin Wu, Krishna H Bhandari, Michael R Doschak
Synthetic parathyroid hormone (PTH) is clinically indicated for the treatment of osteoporosis, through its anabolic effects on parathyroid hormone receptors (PTHRs), located on osteoblast cells. However, the bioavailability of PTH for bone cells is restricted by the short half-life of PTH and the widespread distribution of PTHRs in non-skeletal tissues. To impart affinity for mineralized bone surfaces, bisphosphonate (BP)-mediated PTH analogues were synthesized, characterized, and evaluated in vitro and in vivo...
July 18, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28717995/ovomucin-nanoparticles-promising-carriers-for-mucosal-delivery-of-drugs-and-bioactive-compounds
#2
Ali Akbari, Jianping Wu
Ovomucin, with a similar structure to mucin and gelation ability at room temperature, is a potential mucosal carrier. To evaluate this potential, the mucoadhesive property of ovomucin was studied by the tensile strength and rheology methods, and compared with three known mucoadhesive polymers, chitosan, polyacrylic acid (PAA), and alginate. Ovomucin particles were basically spherical in shape with an average size of ~572, 235 and 54 nm prepared at pH 5, 6.5, and 9, respectively. The absolute value of the zeta potential increased from ~ -51 mV at pH 5 to ~ -59 and -91 mV at pH 6...
July 17, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28707265/editorial
#3
EDITORIAL
Michael R Doschak, Christine Allen, Emmanuel Ho
No abstract text is available yet for this article.
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28707264/evaluation-of-propylene-glycol-nanoliposomes-containing-curcumin-on-burn-wound-model-in-rat-biocompatibility-wound-healing-and-anti-bacterial-effects
#4
Nooshin Kianvash, Abbas Bahador, Maryam Pourhajibagher, Homanaz Ghafari, Vahid Nikoui, Sayed Mehdi Rezayat, Ahmad Reza Dehpour, Alireza Partoazar
Curcumin is an effective wound healing agent in burn therapy, but due to its low bioavailability, it is required to be formulated for topical therapy. Liposomal nanocarriers are developed as stable and efficient dermal delivery systems. In this study, we prepared curcumin-propylene glycol liposomes (Cur-PgL) to treat animals subjected to second degree burns. The characterization tests confirmed the production of monodisperse nanoliposomes of average size of about 145 nm with high entrapment efficiency percentage and a sustained release behavior...
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28707263/delivery-of-viral-vectors-for-gene-therapy-in-intimal-hyperplasia-and-restenosis-in-atherosclerotic-swine
#5
REVIEW
Sannette Hall, Devendra K Agrawal
Cardiovascular diseases including atherosclerosis are a major financial and health burden globally. Inflammation associated with atherosclerosis results in the development of plaques that can rupture causing thrombosis, stroke, or death. The most widely used treatment for the removal of atherosclerotic plaques is percutaneous transluminal coronary angioplasty (PTCA) with or without stenting. Although this is a safer and minimally invasive method, restenosis and intimal hyperplasia after interventional procedure remains a major hurdle and more refined approaches are needed...
July 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28695431/the-antitumor-efficacy-of-docetaxel-is-enhanced-by-encapsulation-in-novel-amphiphilic-polymer-cholesterol-coupled-tocopheryl-polyethylene-glycol-1000-succinate-micelles
#6
Qingjing Tian, Jia Shi, Xiaoyun Zhao, Donghua Di, Yihui Deng, Yanzhi Song
Tocopheryl polyethylene glycol 1000 succinate (TPGS) is considered a promising surfactant, but its high critical micelle concentration (CMC) limits its application. Cholesterol is hydrophobic, can act as a tumor-targeting ligand, and has strong binding ability with taxoids. Based on this information, we coupled cholesterol with TPGS to synthesize cholesterol-coupled TPGS (TPGS-CHMC), which had a lower CMC than pure TPGS. The TPGS-CHMC was used to prepare micelles loading with docetaxel (DTX) by a self-assembly method...
July 10, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28677033/preparation-and-evaluation-of-self-microemulsions-for-improved-bioavailability-of-ginsenoside-rh1-and-rh2
#7
Feifei Yang, Jing Zhou, Xiao Hu, Stephanie Kyoungchun Yu, Chunyu Liu, Ruile Pan, Qi Chang, Xinmin Liu, Yonghong Liao
Due to intestinal cytochrome P450 (CYP450)-mediated metabolism and P-glycoprotein (P-gp) efflux, poor oral bioavailability hinders ginsenoside-Rh1 (Rh1) and ginsenoside-Rh2 (Rh2) from clinical application. In this study, Rh1 and Rh2 were incorporated into two self-microemulsions (SME-1 and SME-2) to improve oral bioavailability. SME-1 contained both CYP450 and P-gp inhibitory excipients while SME-2 only consisted of P-gp inhibitory excipients. Results for release, cellular uptake, transport, and lymph node distribution demonstrated no significant difference between either self-microemulsions in vivo, but were elevated significantly in comparison to the free drug...
July 5, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28677032/molecular-mechanism-of-polymer-assisting-supersaturation-of-poorly-water-soluble-loratadine-based-on-experimental-observations-and-molecular-dynamic-simulations
#8
Shenwu Zhang, Mengchi Sun, Yongshan Zhao, Xuyang Song, Zhonggui He, Jian Wang, Jin Sun
Polymers have been usually used to retard nucleation and crystal growth in order to maintain supersaturation, yet their roles in inhibition of nucleation and crystal growth are poorly understood. In our work, the polymer-based supersaturation performances and molecular mechanisms of poorly aqueous soluble loratadine were investigated. Two common hydrophilic polymers (hydroxylpropylmethyl cellulose acetate succinate (HPMC-AS) and poly(vinylpyrrolidone-co-vinyl-acetate) (PVP-VA)) were used. It was found that HPMC-AS was a better polymer to prevent drug molecules from aggregation and to maintain the supersaturated state in solution than PVP-VA...
July 5, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28656488/the-role-of-monocyte-subpopulations-in-vascular-injury-following-partial-and-transient-depletion
#9
Etty Grad, Ksenia Zolotarevsky, Haim D Danenberg, Mirjam M Nordling-David, Dikla Gutman, Gershon Golomb
The innate immunity system plays a critical role in vascular repair and restenosis development. Liposomes encapsulating bisphosphonates (LipBPs), but not free BPs, suppress neointima formation following vascular injury mediated in part by monocytes. The objective of this study was to elucidate the role of monocyte subpopulations on vascular healing following LipBP treatment. The potency- and dose-dependent treatment effect of clodronate (CLOD) and alendronate (ALN) liposomes on restenosis inhibition, total monocyte depletion, and monocytes subpopulation was studied...
June 27, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28653286/user-input-in-iterative-design-for-prevention-product-development-leveraging-interdisciplinary-methods-to-optimize-effectiveness
#10
Kate M Guthrie, Rochelle K Rosen, Sara E Vargas, Melissa Guillen, Arielle L Steger, Melissa L Getz, Kelley A Smith, Jaime J Ramirez, Erna M Kojic
The development of HIV-preventive topical vaginal microbicides has been challenged by a lack of sufficient adherence in later stage clinical trials to confidently evaluate effectiveness. This dilemma has highlighted the need to integrate translational research earlier in the drug development process, essentially applying behavioral science to facilitate the advances of basic science with respect to the uptake and use of biomedical prevention technologies. In the last several years, there has been an increasing recognition that the user experience, specifically the sensory experience, as well as the role of meaning-making elicited by those sensations, may play a more substantive role than previously thought...
June 26, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28639139/ex-vivo-permeation-of-erythropoietin-through-porcine-conjunctiva-cornea-and-sclera
#11
Ana Paula Resende, Beatriz Silva, Berta São Braz, Telmo Nunes, Lídia Gonçalves, Esmeralda Delgado
The aim of this study is to test the permeation of human recombinant erythropoietin (rHuEPO) across conjunctiva, cornea, and sclera in an ex vivo model. Thirty fresh pig eyes were collected from a slaughterhouse. Conjunctivas (n = 10), corneas (n = 10), and scleras (n = 10) were surgically dissected from surrounding tissues. Ocular membranes were placed into Franz diffusion cells and rHuEPO was administered into the donor phase of each cell, except for control samples. Samples were collected from the receptor phase at seven time points, from 30 min to 6 h of incubation...
June 21, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28639138/veterinary-vaccine-nanotechnology-pulmonary-and-nasal-delivery-in-livestock-animals
#12
REVIEW
Daniella Calderon-Nieva, Kalhari Bandara Goonewardene, Susantha Gomis, Marianna Foldvari
Veterinary vaccine development has several similarities with human vaccine development to improve the overall health and well-being of species. However, veterinary goals lean more toward feasible large-scale administration methods and low cost to high benefit immunization. Since the respiratory mucosa is easily accessible and most infectious agents begin their infection cycle at the mucosa, immunization through the respiratory route has been a highly attractive vaccine delivery strategy against infectious diseases...
June 21, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28612340/long-acting-systemic-hiv-pre-exposure-prophylaxis-an-examination-of-the-field
#13
REVIEW
William R Lykins, Ellen Luecke, Daniel Johengen, Ariane van der Straten, Tejal A Desai
Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentrations. This is especially true for women, who experience less forgiveness from dose skipping than men in clinical trials of HIV PrEP. There is increasing interest in long-acting (LA), user-independent forms of HIV PrEP that could overcome this adherence challenge...
June 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28600625/an-intravaginal-ring-that-releases-three-antiviral-agents-and-a-contraceptive-blocks-shiv-rt-infection-reduces-hsv-2-shedding-and-suppresses-hormonal-cycling-in-rhesus-macaques
#14
Nina Derby, Meropi Aravantinou, Jessica Kenney, Shweta R Ugaonkar, Asa Wesenberg, Jolanta Wilk, Larisa Kizima, Aixa Rodriguez, Shimin Zhang, Olga Mizenina, Keith Levendosky, Michael L Cooney, Samantha Seidor, Agegnehu Gettie, Brooke Grasperge, James Blanchard, Michael Piatak, Jeffrey D Lifson, José Fernández-Romero, Thomas M Zydowsky, Melissa Robbiani
Women globally need access to multipurpose prevention technologies (MPTs) that prevent human immunodeficiency virus (HIV), sexually transmitted infections that increase HIV acquisition/transmission risk, and unintended pregnancy. Seeking an MPT with activity against HIV, herpes simplex virus-2 (HSV-2), and human papillomavirus (HPV), we developed a prototype intravaginal ring (IVR), the MZCL IVR, which released the antiviral agents MIV-150, zinc acetate, and carrageenan (MZC for short) and the contraceptive levonorgestrel (LNG)...
June 9, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28597123/vaginal-drug-delivery-for-the-localised-treatment-of-cervical-cancer
#15
REVIEW
Ian Major, Christopher McConville
Cervical cancer is usually treated by surgery, with the more advanced cancers requiring adjuvant chemotherapy or radiotherapy. The location of the cervix makes it easily accessible through the vagina for the localised delivery of chemotherapeutic drugs. Localised delivery has the advantage of direct delivery to the site of action resulting in a lower dose having to be required and a reduction in systemic side effects. This approach would be advantageous for fertility sparing surgery, whereby localised delivery could be used to reduce tumour size allowing for a much smaller tumour to be removed, reducing the risk of preterm birth...
June 8, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28597122/nanoparticle-in-gel-system-for-delivery-of-vitamin-c-for-topical-application
#16
Sanjukta Duarah, Ramya Devi Durai, VedhaHari B Narayanan
Hyperpigmentation is a dermal condition of melanocyte proliferation, induced by various factors like ultraviolet radiation producing reactive oxygen species, DNA damage, and apoptosis. The application of topical antioxidants through the different type of formulations can help to prevent oxidative damage to the skin. L-ascorbic acid (vitamin C) is a water-soluble compound and the most abundant antioxidant in human skin, but this vitamin is unstable and loses its potency with poor formulation strategies. Nanotechnology has been effectively used to promote stability and therapeutic activity of various drug molecules...
June 8, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28589454/synthesis-physico-chemical-characterization-and-antioxidant-effect-of-pegylated-cerium-oxide-nanoparticles
#17
Yingfei Xue, Sricharani Rao Balmuri, Akhil Patel, Vinayak Sant, Shilpa Sant
Cerium oxide nanoparticles (CNPs) represent a promising class of antioxidant nanoparticles with potential therapeutic value. Due to the easily reversible oxidation states of cerium (Ce(3+) and Ce(4+)) at the nanoscale, CNPs scavenge excessive reactive oxygen and nitrogen species in a self-regenerative manner. In this study, we have demonstrated a simple method to functionalize shape-specific CNPs (i.e., rod- and cube-shaped) with polyethylene glycol (PEG) and studied the effect of PEGylation on the physico-chemical properties, antioxidant activity, and biocompatibility of rod- and cube-shaped CNPs...
June 6, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28589453/bone-seeking-agents-for-the-treatment-of-bone-disorders
#18
REVIEW
Jacqueline Cawthray, Ellen Wasan, Kishor Wasan
The targeting and delivery of therapeutic and diagnostic agents to bone tissue presents both a challenge and opportunity. Osteoporosis, Paget's disease, cancer, and bone metastases are all skeletal diseases whose treatment would benefit from new targeted therapeutic strategies. Osteoporosis, in particular, is a very prevalent disease, affecting over one in three women and one in five men in Canada alone with the cost to the healthcare system estimated at over $2.3 billion in 2010. Bone tissue is often considered a rigid structure when in reality there is a process of continuous remodeling that takes place via complex endocrine-regulated cell signaling pathways in addition to the signaling pathways unique to bone tissue...
June 6, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28589452/on-demand-microbicide-products-design-matters
#19
REVIEW
Sravan Kumar Patel, Lisa Cencia Rohan
Sexual intercourse (vaginal and anal) is the predominant mode of human immunodeficiency virus (HIV) transmission. Topical microbicides used in an on-demand format (i.e., immediately before or after sex) can be part of an effective tool kit utilized to prevent sexual transmission of HIV. The effectiveness of prevention products is positively correlated with adherence, which is likely to depend on user acceptability of the product. The development of an efficacious and acceptable product is therefore paramount for the success of an on-demand product...
June 6, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28534130/tissue-distribution-and-dermal-drug-determination-of-indomethacin-transdermal-absorption-patches
#20
Jingjing Ma, Ying Gao, Yinghua Sun, Dawei Ding, Qi Zhang, Bingjun Sun, Menglin Wang, Jin Sun, Zhonggui He
The tissue distribution and percutaneous drug absorption of indomethacin (IND) patches were studied using commercial IND as a comparison. The concentration of IND in skin, plasma, and muscle in mice was measured by LC-MS/MS, and the IND concentration in the dermis of rats was also monitored by microdialysis. After percutaneous administration, the "double-peak" phenomenon occurred in different tissues, and the IND concentration was ranked as skin first, followed by plasma and then muscle. In particular, skin acted as a reservoir for drug release, and the "secondary hump" in tissue distribution was attributed to the subsequent release of lipophilic IND in skin...
May 22, 2017: Drug Delivery and Translational Research
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