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Parkinson's Disease

Luis I Gómez-Jordana, James Stafford, C Lieke E Peper, Cathy M Craig
Studying freezing of gait (FOG) in the lab has proven problematic. This has primarily been due to the difficulty in designing experimental setups that maintain high levels of ecological validity whilst also permitting sufficient levels of experimental control. To help overcome these challenges, we have developed a virtual reality (VR) environment with virtual doorways, a situation known to illicit FOG in real life. To examine the validity of this VR environment, an experiment was conducted, and the results were compared to a previous "real-world" experiment...
2018: Parkinson's Disease
XiaoPing Wang, XiJin Wang, HaiBo Chen, Sarah Duff Canning, Xingguang Luo
No abstract text is available yet for this article.
2018: Parkinson's Disease
Perla Massai, Francesca Colalelli, Julita Sansoni, Donatella Valente, Marco Tofani, Giovanni Fabbrini, Andrea Fabbrini, Michela Scuccimarri, Giovanni Galeoto
Introduction: The Geriatric Depression Scale (GDS) is commonly used to assess depressive symptoms, but its psychometric properties have never been examined in Italian people with Parkinson's disease (PD). The aim of this study was to study the reliability and validity of the Italian version of the GDS in a sample of PD patients. Methods: The GDS was administered to 74 patients with PD in order to study its internal consistency, test-retest reliability, construct, and discriminant validity...
2018: Parkinson's Disease
Anja Ophey, Carsten Eggers, Richard Dano, Lars Timmermann, Elke Kalbe
The most frequently used instrument to assess health-related quality of life (HrQoL) in Parkinson's disease (PD) is the Parkinson's Disease Questionnaire 39 (PDQ-39). However, both the dimensionality of the eight PDQ-39 subscales and their summary score recently faced criticism. Furthermore, data on disease-related and neuropsychological determinants and the role of gender on HrQoL in PD are inconclusive yet. Therefore, our aim was to reevaluate the PDQ-39 structure and to further explore determinants of HrQoL in PD...
2018: Parkinson's Disease
Catharina Sjödahl Hammarlund, Albert Westergren, Ingrid Åström, Anna-Karin Edberg, Peter Hagell
This study explores the impact of living with Parkinson's disease (PD). Nineteen persons (11 women) aged 55-84 diagnosed with PD 3-27 years ago participated. Data were collected through semistructured interviews, which were recorded, transcribed verbatim, and analysed by qualitative content analysis. Four categories represented the impact of living with PD: "Changed prerequisites for managing day-to-day demands," "Loss of identity and dignity," "Compromised social participation," and "The use of practical and psychological strategies...
2018: Parkinson's Disease
Mehmet Sorar, Sahin Hanalioglu, Bilge Kocer, Muhammed Taha Eser, Selim Selcuk Comoglu, Hayri Kertmen
Objective: Deep brain stimulation (DBS) surgery has increasingly been performed for the treatment of movement disorders and is associated with a wide array of complications. We aimed to present our experience and discuss strategies to minimize adverse events in light of this contemporary series and others in the literature. Methods: A retrospective chart review was conducted to collect data on age, sex, indication, operation date, surgical technique, and perioperative and late complications...
2018: Parkinson's Disease
Alon Sinai, Yeshayahu Katz, Menashe Zaaroor, Olga Sandler, Ilana Schlesinger
Ablative incisionless neurosurgery has become possible through advances in focused ultrasound and magnetic resonance imaging (MRI). The great advantage of MRI-guided focused ultrasound (MRgFUS) is that the ablation is performed through an intact skull without surgery. Here, we review the new modality of MRgFUS for treating tremor and enlighten the role of the anesthesiologist in the unique procedural setting of the MRI suite. During the MRgFUS process, the patients should be awake and are required to cooperate with the medical staff to allow assessment of tremor reduction and potential occurrence of adverse effects...
2018: Parkinson's Disease
Wei Di, Zhiyong Zeng, Jingyan Li, Xiaoling Liu, Minzhi Bo, Hua Lv
Numerous studies have investigated the relationship between the LRRK2 G2385R variant and clinical characteristics in Parkinson's disease (PD), but the results have been inconsistent. This study investigated whether the LRRK2 G2385R variant was associated with a unique clinical phenotype of PD in the Asian population, using a meta-analysis. The PubMed, Web of Science, EMBASE, CNKI, and WANFANG databases were searched until September 2017. The strict selection criteria and exclusion criteria were determined, and mean differences (MD) or odds ratios (OR) with 95% confidence intervals (CI) were used to assess the strength of associations...
2018: Parkinson's Disease
Song-Bin He, Chun-Yan Liu, Lin-di Chen, Zhi-Nan Ye, Ya-Ping Zhang, Wei-Guo Tang, Bin-da Wang, Xiang Gao
Background: Previous studies suggested that visual evoked potential (VEP) was impaired in patients with Parkinson's disease (PD), but the results were inconsistent. Methods: We conducted a systematic review and meta-analysis to explore whether the VEP was significantly different between PD patients and healthy controls. Case-control studies of PD were selected through an electronic search of the databases PubMed, Embase, and the Cochrane Central Register of Controlled Trials...
2018: Parkinson's Disease
Yiğit Çanga, Ayşe Emre, Gülbün Asuman Yüksel, Mehmet Baran Karataş, Nizamettin Selçuk Yelgeç, Ufuk Gürkan, Ali Nazmi Çalık, Hülya Tireli, Sait Terzi
Background: An increased risk of ischemic stroke has been reported in patients with Parkinson's disease (PD). Atrial fibrillation (AF) is strongly associated with ischemic stroke. Prolonged atrial electromechanical delay (EMD) is an independent predictor for the development of AF. Aims: The aim of the present study was to evaluate the atrial conduction parameters in patients with PD and to assess their relation with the severity of PD. Study design: We prospectively enrolled 51 consecutive patients with newly diagnosed PD and 31 age- and sex-matched non-PD subjects...
2018: Parkinson's Disease
Jeremy Steinberger, Jeffrey Gilligan, Branko Skovrlj, Christopher A Sarkiss, Javier Z Guzman, Samuel K Cho, John M Caridi
Study Design: Retrospective Database Analysis. Objective: The purpose of this study was to assess characteristics and outcomes of patients with Parkinson's disease (PD) undergoing lumbar spine surgery for degenerative conditions. Methods: The Nationwide Inpatient Sample was examined from 2002 to 2011. Patients were included for study based on ICD-9-CM procedural codes for lumbar spine surgery and substratified to degenerative diagnoses. Incidence and baseline patient characteristics were determined...
2018: Parkinson's Disease
A M Martínez-Martínez, O M Aguilar, C A Acevedo-Triana
[This corrects the article DOI: 10.1155/2017/9641392.].
2018: Parkinson's Disease
Stefano Gambardella, Rosangela Ferese, Simona Scala, Stefania Carboni, Francesca Biagioni, Giardina Emiliano, Stefania Zampatti, Nicola Modugno, Francesco Fabbiano, Francesco Fornai, Diego Centonze, Stefano Ruggieri
Deletion at 22q11.2 responsible for Di George syndrome (DGs) is a risk factor for early-onset Parkinson's disease (EOPD). To date, all patients reported with 22q11.2 deletions and parkinsonian features are negative for a family history of PD, and possible mutations in PD-related genes were not properly evaluated. The goal of this paper was to identify variants in PD genes that could contribute, together with 22q11.2 del, to the onset of parkinsonian features in patients affected by Di George syndrome. To this aim, sequencing analysis of 4800 genes including 17 PD-related genes was performed in a patient affected by DGs and EOPD...
2018: Parkinson's Disease
Donatas Lukšys, Gintaras Jonaitis, Julius Griškevičius
Background: Parkinson's disease (PD) is a neurodegenerative disorder that affects human voluntary movements. Tremor is one of the most common symptoms of PD and is expressed as involuntary oscillation of the body. Tremors can be analysed in the frequency domain. Objective: The aim of the current study was to examine selected tremor parameters (frequency, root mean square, and approximated entropy) in order to quantify the characteristics of patients diagnosed with PD, compared to a healthy control group, and to compare the parameters by dividing the subjects according to UPDRS assessment...
2018: Parkinson's Disease
Jennifer A Foley, Tom Foltynie, Patricia Limousin, Lisa Cipolotti
DBS is an increasingly offered advanced treatment for Parkinson's disease (PD). Neuropsychological assessment is considered to be an important part of the screening for selection of candidates for this treatment. However, no standardised screening procedure currently exists. In this study, we examined the use of our standardised neuropsychological assessment for the evaluation of surgical candidates and to identify risk factors for subsequent decline in cognition and mood. A total of 40 patients were assessed before and after DBS...
2018: Parkinson's Disease
Ying Wang, Yongsheng Li, Xiaona Zhang, Anmu Xie
Bilateral deep brain stimulation of subthalamic nucleus (STN-DBS) has proven effective in improving motor symptoms in Parkinson's disease (PD) patients. However, psychiatric changes after surgery are controversial. In this study, we specifically analyzed apathy following bilateral STN-DBS in PD patients using a meta-analysis. Relevant articles utilized for this study were obtained through literature search on PubMed, ScienceDirect, and Embase databases. The articles included were those contained both pre- and postsurgery apathy data acquired using the Starkstein Apathy Scale or Apathy Evaluation Scale with patient follow-up of at least three months...
2018: Parkinson's Disease
Jihoon Jang, Soyeon Jeong, Sung Ik Lee, Wongi Seol, Hyemyung Seo, Ilhong Son, Dong Hwan Ho
Parkinson's disease (PD) is the second most common neurodegenerative disease. Oxidative stress is the most critical risk factor for neurodegenerative diseases, including Alzheimer's disease (AD) and Huntington's disease (HD). Numerous reports have demonstrated that oxidative stress aggravates cytotoxicity in dopaminergic neurons and accelerates the formation of protein inclusions. In addition, oxidative stress, such as 4-hydroxynonenal (HNE), oxidized protein, and dopamine quinone, are related to PD progression...
2018: Parkinson's Disease
Jennifer A Foley, Elaine H Niven, Andrew Paget, Kailash P Bhatia, Simon F Farmer, Paul R Jarman, Patricia Limousin, Thomas T Warner, Huw R Morris, Thomas H Bak, Sharon Abrahams, Lisa Cipolotti
Disentangling Parkinson's disease (PD) and progressive supranuclear palsy (PSP) may be a diagnostic challenge. Cognitive signs may be useful, but existing screens are often insufficiently sensitive or unsuitable for assessing people with motor disorders. We investigated whether the newly developed ECAS, designed to be used with people with even severe motor disability, was sensitive to the cognitive impairment seen in PD and PSP and able to distinguish between these two disorders. Thirty patients with PD, 11 patients with PSP, and 40 healthy controls were assessed using the ECAS, as well as an extensive neuropsychological assessment...
2018: Parkinson's Disease
Marjolein A E van Stiphout, Johan Marinus, Jacobus J van Hilten, Frank Lobbezoo, Cees de Baat
The aim of the study was to examine the oral health status of Parkinson's disease (PD) patients, to compare their oral health status to that of a control group, and to relate it to the duration and severity of PD. Materials and Methods . 74 PD patients and 74 controls were interviewed and orally examined. Among PD patients, the duration and the Hoehn and Yahr stage (HY) of the disease were registered. Results . More PD patients than controls reported oral hygiene care support as well as chewing/biting problems, taste disturbance, tooth mobility, and xerostomia, whereas dentate patients had more teeth with carious lesions, tooth root remnants, and biofilm...
2018: Parkinson's Disease
Payam Saadat, Alijan Ahmadi Ahangar, Seyed Ehsan Samaei, Alireza Firozjaie, Fatemeh Abbaspour, Sorrayya Khafri, Azam Khoddami
Background and Purpose: Due to the high prevalence of Parkinson's disease (PD) in the elderly, a large financial burden is imposed on the families and health systems of countries in addition to the problems related to the mobility impairment caused by the disease for the patients. Studies on controversial issues in this disease are taken into consideration, and one of these cases is the role of serum homocysteine level in Parkinson's patients. In this study, the serum level of homocysteine and its association with various variables in relation to this disease was compared with healthy individuals...
2018: Parkinson's Disease
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