journal
MENU ▼
Read by QxMD icon Read
search

Parkinson's Disease

journal
https://www.readbyqxmd.com/read/29147598/dbs-programming-an-evolving-approach-for-patients-with-parkinson-s-disease
#1
REVIEW
Aparna Wagle Shukla, Pam Zeilman, Hubert Fernandez, Jawad A Bajwa, Raja Mehanna
Deep brain stimulation (DBS) surgery is a well-established therapy for control of motor symptoms in Parkinson's disease. Despite an appropriate targeting and an accurate placement of DBS lead, a thorough and efficient programming is critical for a successful clinical outcome. DBS programming is a time consuming and laborious manual process. The current approach involves use of general guidelines involving determination of the lead type, electrode configuration, impedance check, and battery check. However there are no validated and well-established programming protocols...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29147597/psychometric-evaluation-of-the-parkinson-s-disease-activities-of-daily-living-scale
#2
Stina B Jonasson, Peter Hagell, Gun-Marie Hariz, Susanne Iwarsson, Maria H Nilsson
Objective: To evaluate a set of psychometric properties (i.e., data completeness, targeting, and external construct validity) of the Parkinson's disease Activities of Daily Living Scale (PADLS) in people with Parkinson's disease (PD). Specific attention was paid to the association between PADLS and PD severity, according to the Hoehn & Yahr (H&Y) staging. Methods: The sample included 251 persons with PD (mean age 70 [SD 9] years). Data collection comprised a self-administered postal survey, structured interviews, and clinical assessments at home visits...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29119036/technology-assisted-rehabilitation-of-writing-skills-in-parkinson-s-disease-visual-cueing-versus-intelligent-feedback
#3
Evelien Nackaerts, Alice Nieuwboer, Elisabetta Farella
Recent research showed that visual cueing can have both beneficial and detrimental effects on handwriting of patients with Parkinson's disease (PD) and healthy controls depending on the circumstances. Hence, using other sensory modalities to deliver cueing or feedback may be a valuable alternative. Therefore, the current study compared the effects of short-term training with either continuous visual cues or intermittent intelligent verbal feedback. Ten PD patients and nine healthy controls were randomly assigned to one of these training modes...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29104810/management-of-psychosis-in-parkinson-s-disease-emphasizing-clinical-subtypes-and-pathophysiological-mechanisms-of-the-condition
#4
REVIEW
Raquel N Taddei, Seyda Cankaya, Sandeep Dhaliwal, K Ray Chaudhuri
Investigation into neuropsychiatric symptoms in Parkinson's disease (PD) is sparse and current drug development is mainly focused on the motor aspect of PD. The tight association of psychosis with an impaired quality of life in PD, together with an important underreporting of this comorbid condition, contributes to its actual insufficient assessment and management. Furthermore, the withdrawal from access to readily available treatment interventions is unacceptable and has an impact on PD prognosis. Despite its impact, to date no standardized guidelines to the adequate management of PD psychosis are available and they are therefore highly needed...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29093980/the-importance-of-connection-to-others-in-qol-in-msa-and-psp
#5
Louise Wiblin, Rory Durcan, Mark Lee, Katie Brittain
Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) are atypical Parkinsonian disorders with extended morbidity and reduced lifespan, known to have marked and early impact upon quality of life (QoL). This study aimed to address the lack of studies in the literature regarding personal perspectives on QoL in MSA and PSP in both patients and carers. Participants took part in qualitative, in-depth interviews in the North East of England, exploring what impacts their QoL and their experiences of living with these complex conditions...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29090105/the-outcomes-of-total-hip-replacement-in-patients-with-parkinson-s-disease-comparison-of-the-elective-and-hip-fracture-groups
#6
Pavel Šponer, Tomáš Kučera, Michal Grinac, Aleš Bezrouk, Daniel Waciakowski
INTRODUCTION: The aim of the study was to compare the clinical outcomes following elective and traumatic total hip arthroplasty in Parkinson's disease patients. MATERIALS AND METHODS: Ten patients with osteoarthritis comprise the elective group (mean age at operation 74 years; mean follow-up 82 months). Thirteen patients with femoral fracture comprise the hip fracture group (mean age 76 years; mean follow-up 54 months). All patients were followed up at 6 and 36 months postoperatively and at the time of the latest follow-up...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29075547/can-a-smartphone-diagnose-parkinson-disease-a-deep-neural-network-method-and-telediagnosis-system-implementation
#7
Y N Zhang
Parkinson's disease (PD) is primarily diagnosed by clinical examinations, such as walking test, handwriting test, and MRI diagnostic. In this paper, we propose a machine learning based PD telediagnosis method for smartphone. Classification of PD using speech records is a challenging task owing to the fact that the classification accuracy is still lower than doctor-level. Here we demonstrate automatic classification of PD using time frequency features, stacked autoencoders (SAE), and K nearest neighbor (KNN) classifier...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28951797/earlier-intervention-with-deep-brain-stimulation-for-parkinson-s-disease
#8
REVIEW
Gerson Suarez-Cedeno, Jessika Suescun, Mya C Schiess
Neuromodulation of subcortical areas of the brain as therapy to reduce Parkinsonian motor symptoms was developed in the mid-twentieth century and went through many technical and scientific advances that established specific targets and stimulation parameters. Deep Brain Stimulation (DBS) was approved by the FDA in 2002 as neuromodulation therapy for advanced Parkinson's disease, prompting several randomized controlled trials that confirmed its safety and effectiveness. The implantation of tens of thousands of patients in North America and Europe ignited research into its potential role in early disease stages and the therapeutic benefit of DBS compared to best medical therapy...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28913005/chaperone-based-therapies-for-disease-modification-in-parkinson-s-disease
#9
REVIEW
Erik L Friesen, Mitch L De Snoo, Luckshi Rajendran, Lorraine V Kalia, Suneil K Kalia
Parkinson's disease (PD) is the second most common neurodegenerative disorder and is characterized by the presence of pathological intracellular aggregates primarily composed of misfolded α-synuclein. This pathology implicates the molecular machinery responsible for maintaining protein homeostasis (proteostasis), including molecular chaperones, in the pathobiology of the disease. There is mounting evidence from preclinical and clinical studies that various molecular chaperones are downregulated, sequestered, depleted, or dysfunctional in PD...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28894620/programming-for-stimulation-induced-transient-nonmotor-psychiatric-symptoms-after-bilateral-subthalamic-nucleus-deep-brain-stimulation-for-parkinson-s-disease
#10
Xi Wu, Yiqing Qiu, Keith Simfukwe, Jiali Wang, Jianchun Chen, Xiaowu Hu
BACKGROUND: Stimulation-induced transient nonmotor psychiatric symptoms (STPSs) are side effects following bilateral subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) patients. We designed algorithms which (1) determine the electrode contacts that induce STPSs and (2) provide a programming protocol to eliminate STPS and maintain the optimal motor functions. Our objective is to test the effectiveness of these algorithms. MATERIALS AND METHODS: 454 PD patients who underwent programming sessions after STN-DBS implantations were retrospectively analyzed...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28884038/differential-diagnosis-of-parkinson-disease-essential-tremor-and-enhanced-physiological-tremor-with-the-tremor-analysis-of-emg
#11
Jie Zhang, Yan Xing, Xiuli Ma, Liqun Feng
We investigate the differential diagnostic value of tremor analysis of EMG on Parkinson's disease (PD), essential tremor (ET), and enhanced physiological tremor (EPT). Clinical data from 25 patients with PD, 20 patients with ET, and 20 patients with EPT were collected. The tremor frequency and muscle contraction pattern of the resting, posture, and 500 g and 1000 g overload were recorded. The frequency of PD tremor was 4-6 Hz, and the frequency of ET was also in this range; the frequency of EPT is 6-12 hz having some overlap with PD...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28852579/predictors-of-functional-and-quality-of-life-outcomes-following-deep-brain-stimulation-surgery-in-parkinson-s-disease-patients-disease-patient-and-surgical-factors
#12
Hesham Abboud, Gencer Genc, Nicolas R Thompson, Srivadee Oravivattanakul, Faisal Alsallom, Dennys Reyes, Kathy Wilson, Russell Cerejo, Xin Xin Yu, Darlene Floden, Anwar Ahmed, Michal Gostkowski, Ayman Ezzeldin, Hazem Marouf, Ossama Y Mansour, Andre Machado, Hubert H Fernandez
OBJECTIVE: The primary objective was to evaluate predictors of quality of life (QOL) and functional outcomes following deep brain stimulation (DBS) in Parkinson's disease (PD) patients. The secondary objective was to identify predictors of global improvement. METHODS: PD patients who underwent DBS at our Center from 2006 to 2011 were evaluated by chart review and email/phone survey. Postoperative UPDRS II and EQ-5D were analyzed using simple linear regression adjusting for preoperative score...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28848685/bridging-the-gaps-in-patient-education-for-dbs-surgery-in-parkinson-s-disease
#13
Colleen D Knoop, Robert Kadish, Kathy Hager, Michael C Park, Paul D Loprinzi, Kathrin LaFaver
INTRODUCTION: Improvements in quality of life, tremor, and other motor features have been recognized as superior in patients with advanced Parkinson's disease (PD) treated with deep brain stimulation (DBS) surgery versus best medical therapy. We studied a group of patients with PD after undergoing DBS surgery in regard to expectations and satisfaction with DBS outcomes to determine gaps in patient education. METHODS: This study was a retrospective, single academic center chart review and outcome questionnaire sent to patients with PD who had undergone DBS surgery between 2007 and 2014...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28831326/dynamic-changes-in-the-nigrostriatal-pathway-in-the-mptp-mouse-model-of-parkinson-s-disease
#14
REVIEW
Dongping Huang, Jing Xu, Jinghui Wang, Jiabin Tong, Xiaochen Bai, Heng Li, Zishan Wang, Yulu Huang, Yufei Wu, Mei Yu, Fang Huang
The characteristic brain pathology and motor and nonmotor symptoms of Parkinson's disease (PD) are well established. However, the details regarding the causes of the disease and its course are much less clear. Animal models have significantly enriched our current understanding of the progression of this disease. Among various neurotoxin-based models of PD, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model is the most commonly studied model. Here, we provide an overview of the dynamic changes in the nigrostriatal pathway in the MPTP mouse model of PD...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28819579/dual-task-performance-in-gba-parkinson-s-disease
#15
Karin Srulijes, Kathrin Brockmann, Senait Ogbamicael, Markus A Hobert, Ann-Kathrin Hauser, Claudia Schulte, Jasmin Fritzen, Michael Schwenk, Thomas Gasser, Daniela Berg, Walter Maetzler
INTRODUCTION: Parkinson's disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients. METHODS: Eleven GBA-PD patients (p...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28811955/the-effects-of-group-based-versus-individual-based-tai-chi-training-on-nonmotor-symptoms-in-patients-with-mild-to-moderate-parkinson-s-disease-a-randomized-controlled-pilot-trial
#16
Jing Hui Yang, Ya Qun Wang, Sai Qing Ye, You Gen Cheng, Yu Chen, Xiao Zhen Feng
OBJECTIVE: To compare the effects of group-based and individual-based Tai Chi training on nonmotor symptoms in patients with mild to moderate Parkinson's disease. DESIGN: Randomized controlled pilot study. METHODS: 36 community-dwelling patients with Parkinson's disease (PD) were randomly assigned to either group-based training group (n = 19) or individual-based group (n = 17). Both groups received same content of Tai Chi training 3 times a week for 13 weeks...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28798882/evolution-of-orofacial-symptoms-and-disease-progression-in-idiopathic-parkinson-s-disease-longitudinal-data-from-the-j%C3%A3-nk%C3%A3-ping-parkinson-registry
#17
Seyed-Mohammad Fereshtehnejad, Örjan Skogar, Johan Lökk
BACKGROUND: Orofacial symptoms are common in Parkinson's disease (PD) both as initial manifestations and late markers of disease complications. We aimed to investigate the evolution of orofacial manifestations and their prognostic value throughout PD progression. METHODS: Data was obtained from "Jönköping Parkinson Registry" database on routine care visits of 314 people with idiopathic PD in southern Sweden. Information on baseline symptomatology, orofacial features, UPDRS, and medications was recorded at baseline and during each follow-up visit within an average of 4...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28781905/genetic-variants-in-snca-and-the-risk-of-sporadic-parkinson-s-disease-and-clinical-outcomes-a-review
#18
REVIEW
Clarissa Loureiro das Chagas Campêlo, Regina Helena Silva
There is increasing evidence of the contribution of genetic susceptibility to the etiology of Parkinson's disease (PD). Genetic variations in the SNCA gene are well established by linkage and genome-wide association studies. Positive associations of single nucleotide polymorphisms (SNPs) in SNCA and increased risk for PD were found. However, the role of SNCA variants in individual traits or phenotypes of PD is unknown. Here, we reviewed the current literature and identified 57 studies, performed in fourteen different countries, that investigated SNCA variants and susceptibility to PD...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28761773/deep-brain-stimulation-in-parkinson-s-disease-new-and-emerging-targets-for-refractory-motor-and-nonmotor-symptoms
#19
REVIEW
Dustin Anderson, Grayson Beecher, Fang Ba
Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by bradykinesia, tremor, rigidity, and postural instability (PI), in addition to numerous nonmotor manifestations. Many pharmacological therapies now exist to successfully treat PD motor symptoms; however, as the disease progresses, it often becomes challenging to treat with medications alone. Deep brain stimulation (DBS) has become a crucial player in PD treatment, particularly for patients who have disabling motor complications from medical treatment...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28758044/deep-brain-stimulation-of-hemiparkinsonian-rats-with-unipolar-and-bipolar-electrodes-for-up-to-6-weeks-behavioral-testing-of-freely-moving-animals
#20
Kathrin Badstuebner, Ulrike Gimsa, Immo Weber, Armin Tuchscherer, Jan Gimsa
Although the clinical use of deep brain stimulation (DBS) is increasing, its basic mechanisms of action are still poorly understood. Platinum/iridium electrodes were inserted into the subthalamic nucleus of rats with unilateral 6-OHDA-induced lesions of the medial forebrain bundle. Six behavioral parameters were compared with respect to their potential to detect DBS effects. Locomotor function was quantified by (i) apomorphine-induced rotation, (ii) initiation time, (iii) the number of adjusting steps in the stepping test, and (iv) the total migration distance in the open field test...
2017: Parkinson's Disease
journal
journal
43241
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"