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Parkinson's Disease

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https://www.readbyqxmd.com/read/28811955/the-effects-of-group-based-versus-individual-based-tai-chi-training-on-nonmotor-symptoms-in-patients-with-mild-to-moderate-parkinson-s-disease-a-randomized-controlled-pilot-trial
#1
Jing Hui Yang, Ya Qun Wang, Sai Qing Ye, You Gen Cheng, Yu Chen, Xiao Zhen Feng
OBJECTIVE: To compare the effects of group-based and individual-based Tai Chi training on nonmotor symptoms in patients with mild to moderate Parkinson's disease. DESIGN: Randomized controlled pilot study. METHODS: 36 community-dwelling patients with Parkinson's disease (PD) were randomly assigned to either group-based training group (n = 19) or individual-based group (n = 17). Both groups received same content of Tai Chi training 3 times a week for 13 weeks...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28798882/evolution-of-orofacial-symptoms-and-disease-progression-in-idiopathic-parkinson-s-disease-longitudinal-data-from-the-j%C3%A3-nk%C3%A3-ping-parkinson-registry
#2
Seyed-Mohammad Fereshtehnejad, Örjan Skogar, Johan Lökk
BACKGROUND: Orofacial symptoms are common in Parkinson's disease (PD) both as initial manifestations and late markers of disease complications. We aimed to investigate the evolution of orofacial manifestations and their prognostic value throughout PD progression. METHODS: Data was obtained from "Jönköping Parkinson Registry" database on routine care visits of 314 people with idiopathic PD in southern Sweden. Information on baseline symptomatology, orofacial features, UPDRS, and medications was recorded at baseline and during each follow-up visit within an average of 4...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28781905/genetic-variants-in-snca-and-the-risk-of-sporadic-parkinson-s-disease-and-clinical-outcomes-a-review
#3
REVIEW
Clarissa Loureiro das Chagas Campêlo, Regina Helena Silva
There is increasing evidence of the contribution of genetic susceptibility to the etiology of Parkinson's disease (PD). Genetic variations in the SNCA gene are well established by linkage and genome-wide association studies. Positive associations of single nucleotide polymorphisms (SNPs) in SNCA and increased risk for PD were found. However, the role of SNCA variants in individual traits or phenotypes of PD is unknown. Here, we reviewed the current literature and identified 57 studies, performed in fourteen different countries, that investigated SNCA variants and susceptibility to PD...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28761773/deep-brain-stimulation-in-parkinson-s-disease-new-and-emerging-targets-for-refractory-motor-and-nonmotor-symptoms
#4
REVIEW
Dustin Anderson, Grayson Beecher, Fang Ba
Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by bradykinesia, tremor, rigidity, and postural instability (PI), in addition to numerous nonmotor manifestations. Many pharmacological therapies now exist to successfully treat PD motor symptoms; however, as the disease progresses, it often becomes challenging to treat with medications alone. Deep brain stimulation (DBS) has become a crucial player in PD treatment, particularly for patients who have disabling motor complications from medical treatment...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28758044/deep-brain-stimulation-of-hemiparkinsonian-rats-with-unipolar-and-bipolar-electrodes-for-up-to-6-weeks-behavioral-testing-of-freely-moving-animals
#5
Kathrin Badstuebner, Ulrike Gimsa, Immo Weber, Armin Tuchscherer, Jan Gimsa
Although the clinical use of deep brain stimulation (DBS) is increasing, its basic mechanisms of action are still poorly understood. Platinum/iridium electrodes were inserted into the subthalamic nucleus of rats with unilateral 6-OHDA-induced lesions of the medial forebrain bundle. Six behavioral parameters were compared with respect to their potential to detect DBS effects. Locomotor function was quantified by (i) apomorphine-induced rotation, (ii) initiation time, (iii) the number of adjusting steps in the stepping test, and (iv) the total migration distance in the open field test...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28706748/comparison-of-globus-pallidus-interna-and-subthalamic-nucleus-in-deep-brain-stimulation-for-parkinson-disease-an-institutional-experience-and-review
#6
REVIEW
Shazia Mirza, Umar Yazdani, Richard Dewey Iii, Neepa Patel, Richard B Dewey, Svjetlana Miocinovic, Shilpa Chitnis
Deep Brain Stimulation (DBS) has revolutionized the lives of patients of Parkinson disease, offering therapeutic options to those not benefiting entirely from medications alone. With its proven track record of outperforming the best medical management, the goal is to unlock the full potential of this therapy. Currently, the Globus Pallidus Interna (GPi) and Subthalamic Nucleus (STN) are both viable targets for DBS, and the choice of site should focus on the constellation of symptoms, both motor and nonmotor, which are key determinants to quality of life...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28676842/subthalamic-nucleus-deep-brain-stimulation-in-early-stage-parkinson-s-disease-is-not-associated-with-increased-body-mass-index
#7
Sarah H Millan, Mallory L Hacker, Maxim Turchan, Anna L Molinari, Amanda D Currie, David Charles
Previous studies suggest that deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease (PD) leads to weight gain. This study analyzes changes in body mass index (BMI) in 29 subjects from a prospective, single-blind trial of DBS in early stage PD (age 50-75, Hoehn & Yahr stage II off medication, treated with antiparkinsonian medications for ≥6 months but <4 years, and without a history of motor fluctuations, dyskinesias, or dementia). Subjects were randomized to DBS plus optimal drug therapy (DBS+ODT; n = 15) or ODT (n = 14) and followed for 24 months...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28660090/colonic-oxidative-and-mitochondrial-function-in-parkinson-s-disease-and-idiopathic-rem-sleep-behavior-disorder
#8
C Morén, Í González-Casacuberta, J Navarro-Otano, D Juárez-Flores, D Vilas, G Garrabou, J C Milisenda, C Pont-Sunyer, M Catalán-García, M Guitart-Mampel, E Tobías, F Cardellach, F Valldeoriola, A Iranzo, E Tolosa
OBJECTIVE: To determine potential mitochondrial and oxidative alterations in colon biopsies from idiopathic REM sleep behavior disorder (iRBD) and Parkinson's disease (PD) subjects. METHODS: Colonic biopsies from 7 iRBD subjects, 9 subjects with clinically diagnosed PD, and 9 healthy controls were homogenized in 5% w/v mannitol. Citrate synthase (CS) and complex I (CI) were analyzed spectrophotometrically. Oxidative damage was assessed either by lipid peroxidation, through malondialdehyde and hydroxyalkenal content by spectrophotometry, or through antioxidant enzyme levels of superoxide dismutase-2 (SOD2), glutathione peroxidase-1 (Gpx1), and catalase (CAT) by western blot...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28634568/sirtuin-2-protects-neural-cells-from-oxidative-stress-and-is-elevated-in-neurodegeneration
#9
Preeti Singh, Peter S Hanson, Christopher M Morris
Sirtuins are highly conserved lysine deacetylases involved in ageing, energy production, and lifespan extension. The mammalian SIRT2 has been implicated in Parkinson's disease (PD) where studies suggest SIRT2 promotes neurodegeneration. We therefore evaluated the effects of SIRT2 manipulation in toxin treated SH-SY5Y cells and determined the expression and activity of SIRT2 in postmortem brain tissue from patients with PD. SH-SY5Y viability in response to oxidative stress induced by diquat or rotenone was measured following SIRT2 overexpression or inhibition of deacetylase activity, along with α-synuclein aggregation...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28630780/a-randomized-controlled-trial-of-chinese-medicine-on-nonmotor-symptoms-in-parkinson-s-disease
#10
Ka-Kit Chua, Adrian Wong, Kam-Wa Chan, Yin-Kei Lau, Zhao-Xiang Bian, Jia-Hong Lu, Liang-Feng Liu, Lei-Lei Chen, Ka-Ho Chan, Kim-Pong Tse, Anne Chan, Ju-Xian Song, Justin Wu, Li-Xing Zhu, Vincent Mok, Min Li
Nonmotor symptoms (NMS) of Parkinson's disease (PD) have devastating impacts on both patients and their caregivers. Jiawei-Liujunzi Tang (JLT) has been used to treat some NMS of PD based on the Chinese medicine theory since Qing dynasty. Here we report a double-blind, randomized, placebo-controlled, add-on clinical trial aiming at evaluating the efficacy and safety of the JLT in treating NMS in PD patients. We randomly assigned 111 patients with idiopathic PD to receive either JLT or placebo for 32 weeks. Outcome measures were baseline to week 32 changes in Movement Disorder Society-Sponsored Revision of Unified PD Rating Scale (MDS-UPDRS) Parts I-IV and in NMS assessment scale for PD (NMSS)...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28611932/physiotherapy-in-parkinson-s-disease-building-parkinsonnet-in-czechia
#11
Ota Gal, Martin Srp, Romana Konvalinkova, Martina Hoskovcova, Vaclav Capek, Jan Roth, Evzen Ruzicka
OBJECTIVE: We conducted a questionnaire survey to investigate the availability and quality of physiotherapy (PT) for Parkinson's disease (PD). BACKGROUND: Despite evidence about the benefits of PT, there is no data regarding its use in Czechia. METHODS: Questionnaires were sent to 368 PD patients seen in a single movement disorders centre within two years (inclusion criteria: idiopathic PD, Hoehn and Yahr stage <5, and residence in Prague) and to 211 physical therapists (PTs) registered in Prague...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28607801/quantitative-analysis-of-motor-status-in-parkinson-s-disease-using-wearable-devices-from-methodological-considerations-to-problems-in-clinical-applications
#12
REVIEW
Masahiko Suzuki, Hiroshi Mitoma, Mitsuru Yoneyama
Long-term and objective monitoring is necessary for full assessment of the condition of patients with Parkinson's disease (PD). Recent advances in biotechnology have seen the development of various types of wearable (body-worn) sensor systems. By using accelerometers and gyroscopes, these devices can quantify motor abnormalities, including decreased activity and gait disturbances, as well as nonmotor signs, such as sleep disturbances and autonomic dysfunctions in PD. This review discusses methodological problems inherent in wearable devices...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28607800/effect-of-a-traditional-chinese-herbal-medicine-formulation-on-cell-survival-and-apoptosis-of-mpp-treated-mes-23-5-dopaminergic-cells
#13
Shuifen Ye, Ho Kee Koon, Wen Fan, Yihui Xu, Wei Wei, Chuanshan Xu, Jing Cai
Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) is implicated in Parkinson's disease (PD). The efficacy of these currently used drugs is limited while traditional Chinese medicine (TCM) has been used in the management of neurodegenerative diseases for many years. This study was designed to evaluate the effect of a modified traditional Chinese herbal medicine decoction, Cong Rong Jing (CRJ), on cell survival and apoptosis of 1-methyl-4-phenylpyridinium- (MPP(+)-) treated MES23.5 dopaminergic cells...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28540099/genetic-variations-and-mrna-expression-of-nrf2-in-parkinson-s-disease
#14
Caroline Ran, Karin Wirdefeldt, Lovisa Brodin, Mehrafarin Ramezani, Marie Westerlund, Fengqing Xiang, Anna Anvret, Thomas Willows, Olof Sydow, Anders Johansson, Dagmar Galter, Per Svenningsson, Andrea Carmine Belin
Nuclear factor erythroid 2-like 2 (NRF2) encodes a transcription factor regulating mechanisms of cellular protection and is activated by oxidative stress. NRF2 has therefore been hypothesized to confer protection against Parkinson's disease and so far an NRF2 haplotype has been reported to decrease the risk of developing disease and delay disease onset. Also NRF2 adopts a nuclear localization in Parkinson's disease, which is indicative of increased NRF2 activity. We have investigated the association between NRF2 and Parkinson's disease in a Swedish case-control material and whether NRF2 expression levels correlate with NRF2 genetic variants, disease, or disease onset...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28529814/ex-vivo-and-in-vivo-characterization-of-interpolymeric-blend-nanoenabled-gastroretentive-levodopa-delivery-systems
#15
Ndidi C Ngwuluka, Yahya E Choonara, Girish Modi, Lisa C du Toit, Pradeep Kumar, Leith Meyer, Tracy Snyman, Viness Pillay
One approach for delivery of narrow absorption window drugs is to formulate gastroretentive drug delivery systems. This study was undertaken to provide insight into in vivo performances of two gastroretentive systems (PXLNET and IPB matrices) in comparison to Madopar® HBS capsules. The pig model was used to assess gastric residence time and pharmacokinetic parameters using blood, cerebrospinal fluid (CSF), and urine samples. Histopathology and cytotoxicity testing were also undertaken. The pharmacokinetic parameters indicated that levodopa was liberated from the drug delivery systems, absorbed, widely distributed, metabolized, and excreted...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28484661/cognitive-function-characteristics-of-parkinson-s-disease-with-sleep-disorders
#16
Jing Huang, Wenyan Zhuo, Yuhu Zhang, Hongchun Sun, Huan Chen, Peipei Zhu, Xiaobo Pan, Jianhao Yang, Lijuan Wang
Objective. The aim of this study was to investigate the cognitive function characteristics of Parkinson's disease (PD) with sleep disorders. Methods. Consecutive patients with PD (n = 96), patients with primary sleep disorders (n = 76), and healthy control subjects (n = 66) were assessed. The patients with PD were classified into sleep disorder (PD-SD) and non-sleep disorder (PD-NSD) groups. Results. Among 96 patients with PD, 69 were diagnosed with a sleep disorder. There were 38 sleep disorder cases, 31 RBD cases, and 27 NSD cases...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28473940/insights-into-the-mechanisms-involved-in-protective-effects-of-vegf-b-in-dopaminergic-neurons
#17
REVIEW
Beatrice Caballero, Scott J Sherman, Torsten Falk
Vascular endothelial growth factor-B (VEGF-B), when initially discovered, was thought to be an angiogenic factor, due to its intimate sequence homology and receptor binding similarity to the prototype angiogenic factor, vascular endothelial growth factor-A (VEGF-A). Studies demonstrated that VEGF-B, unlike VEGF-A, did not play a significant role in angiogenesis or vascular permeability and has become an active area of interest because of its role as a survival factor in pathological processes in a multitude of systems, including the brain...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28465861/mri-guided-focused-ultrasound-in-parkinson-s-disease-a-review
#18
REVIEW
Ilana Schlesinger, Alon Sinai, Menashe Zaaroor
MRI-guided focused ultrasound is a new technology that enables intracranial ablation. Since lesioning ameliorates some of the symptoms of PD, this technology is being explored as a possible treatment for medication resistant symptoms in PD patients. The purpose of this paper is to review the clinical use and treatment outcomes of PD patients treated to date with this technology.
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28465860/lrrk2-g2019s-mutation-prevalence-and-clinical-features-in-moroccans-with-parkinson-s-disease
#19
Ahmed Bouhouche, Houyam Tibar, Rafiqua Ben El Haj, Khalil El Bayad, Rachid Razine, Sanaa Tazrout, Asmae Skalli, Naima Bouslam, Loubna Elouardi, Ali Benomar, Mohammed Yahyaoui, Wafa Regragui
Background. The LRRK2 G2019S mutation is the most common genetic determinant of Parkinson's disease (PD) identified to date. This mutation, reported in both familial and sporadic PD, occurs at elevated frequencies in Maghreb population. In the present study, we examined the prevalence of the G2019S mutation in the Moroccan population and we compared the motor and nonmotor phenotype of G2019S carriers to patients with idiopathic Parkinson's disease. Methods. 100 PD patients were assessed for motor and nonmotor symptoms, current medication, and motor complication including motor fluctuations and dyskinesia...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28458943/are-patients-ready-for-earlystim-attitudes-towards-deep-brain-stimulation-among-female-and-male-patients-with-moderately-advanced-parkinson-s-disease
#20
Maria Sperens, Katarina Hamberg, Gun-Marie Hariz
Objective. To explore, in female and male patients with medically treated, moderately advanced Parkinson's disease (PD), their knowledge and reasoning about Deep Brain Stimulation (DBS). Methods. 23 patients with PD (10 women), aged 46-70, were interviewed at a mean of 8 years after diagnosis, with open-ended questions concerning their reflections and considerations about DBS. The interviews were transcribed verbatim and analysed according to the difference and similarity technique in Grounded Theory. Results...
2017: Parkinson's Disease
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