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Parkinson's Disease

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https://www.readbyqxmd.com/read/28529814/ex-vivo-and-in-vivo-characterization-of-interpolymeric-blend-nanoenabled-gastroretentive-levodopa-delivery-systems
#1
Ndidi C Ngwuluka, Yahya E Choonara, Girish Modi, Lisa C du Toit, Pradeep Kumar, Leith Meyer, Tracy Snyman, Viness Pillay
One approach for delivery of narrow absorption window drugs is to formulate gastroretentive drug delivery systems. This study was undertaken to provide insight into in vivo performances of two gastroretentive systems (PXLNET and IPB matrices) in comparison to Madopar® HBS capsules. The pig model was used to assess gastric residence time and pharmacokinetic parameters using blood, cerebrospinal fluid (CSF), and urine samples. Histopathology and cytotoxicity testing were also undertaken. The pharmacokinetic parameters indicated that levodopa was liberated from the drug delivery systems, absorbed, widely distributed, metabolized, and excreted...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28484661/cognitive-function-characteristics-of-parkinson-s-disease-with-sleep-disorders
#2
Jing Huang, Wenyan Zhuo, Yuhu Zhang, Hongchun Sun, Huan Chen, Peipei Zhu, Xiaobo Pan, Jianhao Yang, Lijuan Wang
Objective. The aim of this study was to investigate the cognitive function characteristics of Parkinson's disease (PD) with sleep disorders. Methods. Consecutive patients with PD (n = 96), patients with primary sleep disorders (n = 76), and healthy control subjects (n = 66) were assessed. The patients with PD were classified into sleep disorder (PD-SD) and non-sleep disorder (PD-NSD) groups. Results. Among 96 patients with PD, 69 were diagnosed with a sleep disorder. There were 38 sleep disorder cases, 31 RBD cases, and 27 NSD cases...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28473940/insights-into-the-mechanisms-involved-in-protective-effects-of-vegf-b-in-dopaminergic-neurons
#3
REVIEW
Beatrice Caballero, Scott J Sherman, Torsten Falk
Vascular endothelial growth factor-B (VEGF-B), when initially discovered, was thought to be an angiogenic factor, due to its intimate sequence homology and receptor binding similarity to the prototype angiogenic factor, vascular endothelial growth factor-A (VEGF-A). Studies demonstrated that VEGF-B, unlike VEGF-A, did not play a significant role in angiogenesis or vascular permeability and has become an active area of interest because of its role as a survival factor in pathological processes in a multitude of systems, including the brain...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28465861/mri-guided-focused-ultrasound-in-parkinson-s-disease-a-review
#4
REVIEW
Ilana Schlesinger, Alon Sinai, Menashe Zaaroor
MRI-guided focused ultrasound is a new technology that enables intracranial ablation. Since lesioning ameliorates some of the symptoms of PD, this technology is being explored as a possible treatment for medication resistant symptoms in PD patients. The purpose of this paper is to review the clinical use and treatment outcomes of PD patients treated to date with this technology.
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28465860/lrrk2-g2019s-mutation-prevalence-and-clinical-features-in-moroccans-with-parkinson-s-disease
#5
Ahmed Bouhouche, Houyam Tibar, Rafiqua Ben El Haj, Khalil El Bayad, Rachid Razine, Sanaa Tazrout, Asmae Skalli, Naima Bouslam, Loubna Elouardi, Ali Benomar, Mohammed Yahyaoui, Wafa Regragui
Background. The LRRK2 G2019S mutation is the most common genetic determinant of Parkinson's disease (PD) identified to date. This mutation, reported in both familial and sporadic PD, occurs at elevated frequencies in Maghreb population. In the present study, we examined the prevalence of the G2019S mutation in the Moroccan population and we compared the motor and nonmotor phenotype of G2019S carriers to patients with idiopathic Parkinson's disease. Methods. 100 PD patients were assessed for motor and nonmotor symptoms, current medication, and motor complication including motor fluctuations and dyskinesia...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28458943/are-patients-ready-for-earlystim-attitudes-towards-deep-brain-stimulation-among-female-and-male-patients-with-moderately-advanced-parkinson-s-disease
#6
Maria Sperens, Katarina Hamberg, Gun-Marie Hariz
Objective. To explore, in female and male patients with medically treated, moderately advanced Parkinson's disease (PD), their knowledge and reasoning about Deep Brain Stimulation (DBS). Methods. 23 patients with PD (10 women), aged 46-70, were interviewed at a mean of 8 years after diagnosis, with open-ended questions concerning their reflections and considerations about DBS. The interviews were transcribed verbatim and analysed according to the difference and similarity technique in Grounded Theory. Results...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28409050/correlation-of-mri-visual-scales-with-neuropsychological-profile-in-mild-cognitive-impairment-of-parkinson-s-disease
#7
Luiz Felipe Vasconcellos, João Santos Pereira, Marcelo Adachi, Denise Greca, Manuela Cruz, Ana Lara Malak, Helenice Charchat-Fichman, Mariana Spitz
Few studies have evaluated magnetic resonance imaging (MRI) visual scales in Parkinson's disease-Mild Cognitive Impairment (PD-MCI). We selected 79 PD patients and 92 controls (CO) to perform neurologic and neuropsychological evaluation. Brain MRI was performed to evaluate the following scales: Global Cortical Atrophy (GCA), Fazekas, and medial temporal atrophy (MTA). The analysis revealed that both PD groups (amnestic and nonamnestic) showed worse performance on several tests when compared to CO. Memory, executive function, and attention impairment were more severe in amnestic PD-MCI group...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28409049/rivastigmine-as-a-symptomatic-treatment-for-apathy-in-parkinson-s-dementia-complex-new-aspects-for-this-riddle
#8
Rita Moretti, Paola Caruso, Matteo Dal Ben
Over 90% of PDD patients show at least one neuropsychiatric symptom (NPS); in the 60-70% two or more NPS are present. Their incidence is important in terms of prognosis and severity of pathology. However, among all NPS, apathy is often the most disturbing, associated with greater caregiver's burden. Similar to other NPS, apathy may be due to a dysfunction of the nigrostriatal pathway, even though, not all the PD patients become apathetic, indicating that apathy should not entirely be considered a dopamine-dependent syndrome, and in fact it might also be related to acetylcholine defects...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28386511/protective-effects-of-an-ancient-chinese-kidney-tonifying-formula-against-h2o2-induced-oxidative-damage-to-mes23-5-cells
#9
Yihui Xu, Wei Lin, Shuifen Ye, Huajin Wang, Tingting Wang, Youyan Su, Liangning Wu, Yuanwang Wang, Qian Xu, Chuanshan Xu, Jing Cai
Oxidative damage plays a critical role in the etiology of neurodegenerative disorders including Parkinson's disease (PD). In our study, an ancient Chinese kidney-tonifying formula, which consists of Cistanche, Epimedii, and Polygonatum cirrhifolium, was investigated to protect MES23.5 dopaminergic neurons against hydrogen peroxide- (H2O2-) induced oxidative damage. The damage effects of H2O2 on MES23.5 cells and the protective effects of KTF against oxidative stress were evaluated using MTT assay, transmission electron microscopy (TEM), immunocytochemistry (ICC), enzyme-linked immunosorbent assay (ELISA), and immunoblotting...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28357150/systematic-review-and-critical-analysis-of-cost-studies-associated-with-parkinson-s-disease
#10
REVIEW
Tânia M Bovolenta, Sônia Maria Cesar de Azevedo Silva, Roberta Arb Saba, Vanderci Borges, Henrique Ballalai Ferraz, Andre C Felicio
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease worldwide, affecting more than four million people. Typically, it affects individuals above 45, when they are still productive, compromising both aging and quality of life. Therefore, the cost of the disease must be identified, so that the use of resources can be rational and efficient. Additionally, in Brazil, there is a lack of research on the costs of neurodegenerative diseases, such as PD, a gap addressed in this study. This systematic review critically addresses the various methodologies used in original research around the world in the last decade on the subject, showing that costs are hardly comparable...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28357149/festination-correlates-with-snca-polymorphism-in-chinese-patients-with-parkinson-s-disease
#11
Jinhua Zheng, Xinglong Yang, Quanzhen Zhao, Sijia Tian, Hongyan Huang, Yalan Chen, Yanming Xu
The genetic basis of festination, a common motor symptom in Parkinson's disease (PD), remains unclear. Since polymorphism in the alpha-synuclein (SNCA) gene is associated with PD phenotype, we examined whether such polymorphism is also associated with festination. SNCA polymorphisms rs11931074 and rs894278 were genotyped in a consecutive series of 258 patients with PD, of whom 122 (47.3%) suffered festination. Univariate analysis revealed significant differences in genotype and minor allele frequencies at rs11931074 or rs894278 between patients with festination and those without it (all p < 0...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28352490/cost-of-living-with-parkinson-s-disease-over-12-months-in-australia-a-prospective-cohort-study
#12
Shalika Bohingamu Mudiyanselage, Jennifer J Watts, Julie Abimanyi-Ochom, Lisa Lane, Anna T Murphy, Meg E Morris, Robert Iansek
Background. Parkinson disease (PD) is a costly chronic condition in terms of managing both motor and nonmotor symptoms. The burden of disease is high for individuals, caregivers, and the health system. The aim of this study is to estimate the annual cost of PD from the household, health system, and societal perspectives. Methods. A prospective cohort study of newly referred people with PD to a specialist PD clinic in Melbourne, Australia. Participants completed baseline and monthly health resource use questionnaires and Medicare data were collected over 12 months...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28352489/nonmotor-symptoms-of-parkinson-s-disease
#13
EDITORIAL
Shey-Lin Wu, Rajka M Liscic, SangYun Kim, Sandro Sorbi, Yuan-Han Yang
No abstract text is available yet for this article.
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28348918/correlation-of-visuospatial-ability-and-eeg-slowing-in-patients-with-parkinson-s-disease
#14
Dominique Eichelberger, Pasquale Calabrese, Antonia Meyer, Menorca Chaturvedi, Florian Hatz, Peter Fuhr, Ute Gschwandtner
Background. Visuospatial dysfunction is among the first cognitive symptoms in Parkinson's disease (PD) and is often predictive for PD-dementia. Furthermore, cognitive status in PD-patients correlates with quantitative EEG. This cross-sectional study aimed to investigate the correlation between EEG slowing and visuospatial ability in nondemented PD-patients. Methods. Fifty-seven nondemented PD-patients (17 females/40 males) were evaluated with a comprehensive neuropsychological test battery and a high-resolution 256-channel EEG was recorded...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28348917/the-level-of-knowledge-of-parkinson-s-disease-among-nonprofessional-caregivers-in-a-movement-disorders-center-in-turkey
#15
Murat Gultekin, Ayse Caglar Sarılar, Ayten Ekinci, Gozde Erturk, Meral Mirza
Introduction. Only a few studies have been conducted to determine the level of knowledge among caregivers about Parkinson's disease (PD). The aim of the current study was to determine the knowledge of PD among caregivers at a movement disorder clinic in Turkey. Methods. We conducted a questionnaire based interview with the subjects in a tertiary care neurology facility in Turkey. The questions were divided into two parts covering the symptomatology and treatment of PD. A questionnaire consisting of 10 questions was applied to the subjects who had to mark the correct option in a stipulated time...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28316861/complexity-analysis-of-electroencephalogram-dynamics-in-patients-with-parkinson-s-disease
#16
Guotao Liu, Yanping Zhang, Zhenghui Hu, Xiuquan Du, Wanqing Wu, Chenchu Xu, Xiangyang Wang, Shuo Li
In this study, a new combination scheme has been proposed for detecting Parkinson's disease (PD) from electroencephalogram (EEG) signal recorded from normal subjects and PD patients. The scheme is based on discrete wavelet transform (DWT), sample entropy (SampEn), and the three-way decision model in analysis of EEG signal. The EEG signal is noisy and nonstationary, and, as a consequence, it becomes difficult to distinguish it visually. However, the scheme is a well-established methodology in analysis of EEG signal in three stages...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28293444/association-of-gait-characteristics-and-depression-in-patients-with-parkinson-s-disease-assessed-in-goal-directed-locomotion-task
#17
Péter Kincses, Norbert Kovács, Kázmér Karádi, Ádám Feldmann, Krisztina Dorn, Zsuzsanna Aschermann, Sámuel Komoly, Tibor Szolcsányi, Árpád Csathó, János Kállai
Introduction. In the genesis of Parkinson's disease (PD) clinical phenomenology the exact nature of the association between bradykinesia and affective variables is unclear. In the present study, we analyzed the gait characteristics and level of depression in PD and healthy volunteers. Methods. Patients with PD (n = 48) and healthy controls (n = 52) were recruited for the present study. Walking speed, stride length, and cadence were compared between groups while participants completed a goal-directed locomotion task under visually controlled (VC) and visually noncontrolled conditions (VnC)...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28286689/determinants-of-dyadic-relationship-and-its-psychosocial-impact-in-patients-with-parkinson-s-disease-and-their-spouses
#18
Michaela Karlstedt, Seyed-Mohammad Fereshtehnejad, Dag Aarsland, Johan Lökk
The caregiver-care receiver relationship (mutuality) in Parkinson's disease (PD) and its association with motor and non-motors symptoms, health-related quality of life (HRQoL), and caregiver burden have not fully been investigated. The aim of our study was to explore if (1) the level of mutuality perceived by PD-patients and PD-partners differs, (2) different factors are associated with perceived mutuality by PD-patients and PD-partners, and (3) mutuality is associated with PD-patients health-related quality of life (HRQoL) and caregiver burden...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28280646/meta-analysis-of-the-relationship-between-deep-brain-stimulation-in-patients-with-parkinson-s-disease-and-performance-in-evaluation-tests-for-executive-brain-functions
#19
REVIEW
A M Martínez-Martínez, O M Aguilar, C A Acevedo-Triana
Parkinson's disease (PD) is a neurodegenerative condition, which compromises the motor functions and causes the alteration of some executive brain functions. The presence of changes in cognitive symptoms in PD could be due to the procedure of deep brain stimulation (DBS). We searched in several databases for studies that compared performance in executive function tests before and after the DBS procedure in PE and then performed a meta-analysis. After the initial search, there were 15 articles that specifically evaluated the functions of verbal fluency, working memory, cognitive flexibility, abstract thinking, and inhibition...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28265478/twice-daily-versus-once-daily-pramipexole-extended-release-dosage-regimens-in-parkinson-s-disease
#20
Ji Young Yun, Young Eun Kim, Hui-Jun Yang, Han-Joon Kim, Beomseok Jeon
This open-label study aimed to compare once-daily and twice-daily pramipexole extended release (PER) treatment in Parkinson's disease (PD). PD patients on dopamine agonist therapy, but with unsatisfactory control, were enrolled. Existing agonist doses were switched into equivalent PER doses. Subjects were consecutively enrolled into either once-daily-first or twice-daily-first groups and received the prescribed amount in one or two, respectively, daily doses for 8 weeks. For the second period, subjects switched regimens in a crossover manner...
2017: Parkinson's Disease
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