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Parkinson's Disease

John C Morgan, Rohit Dhall, Robert Rubens, Sarita Khanna, Suneel Gupta
Background: IPX066 is an extended-release (ER) oral formulation of carbidopa-levodopa (CD-LD). Following an initial peak at about one hour, plasma LD concentrations are maintained for about 4-5 hours. Objective: To present dosing factors that may affect the successful conversion to ER CD-LD from other LD formulations. Methods: Two-phase 3 studies of ER CD-LD vs. immediate-release (IR) CD-LD (ADVANCE-PD) and vs. CD-LD + entacapone (CLE; ASCEND-PD) in subjects with advanced PD included a 6-week, open-label conversion to ER CD-LD prior to treatment randomization...
2018: Parkinson's Disease
Micaela Porta, Giuseppina Pilloni, Roberta Pili, Carlo Casula, Mauro Murgia, Giovanni Cossu, Massimiliano Pau
Background: Although physical activity (PA) is known to be beneficial in improving motor symptoms of people with Parkinson's disease (pwPD), little is known about the relationship between gait patterns and features of PA performed during daily life. Objective: To verify the existence of possible relationships between spatiotemporal and kinematic parameters of gait and amount/intensity of PA, both instrumentally assessed. Methods: Eighteen individuals affected by PD (10F and 8M, age 68...
2018: Parkinson's Disease
Giulia Di Lazzaro, Tommaso Schirinzi, Maria Pia Giambrone, Roberta Di Mauro, Maria Giuseppina Palmieri, Camilla Rocchi, Michele Tinazzi, Nicola Biagio Mercuri, Stefano Di Girolamo, Antonio Pisani
Introduction: Pisa syndrome (PS) is a postural complication of Parkinson's disease (PD). Yet, its pathophysiology remains unclear, although a multifactorial component is probable. Cervical vestibular evoked myogenic potentials (cVEMPs) explore vestibulospinal pathway, but they have not been measured yet in PD patients with PS (PDPS) to assess a potential vestibular impairment. Materials and Methods: We enrolled 15 PD patients, 15 PDPS patients, and 30 healthy controls (HCs)...
2018: Parkinson's Disease
Suisui Pang, Jia Li, Yingyu Zhang, Jiajun Chen
Purpose: To clarify the relationship between certain genotypes or alleles of the APOE gene and the onset risk of Parkinson's disease dementia (PDD). Methods: The PubMed, Cochrane, Embase, CBM, CNKI, and Wanfang databases were searched to identify all case-control studies and cohort studies published before October 30, 2017, that investigated the association between the APOE gene and the onset of PDD. Manual information retrieval was also performed. All studies that met the quality requirements were included in a meta-analysis performed using RevMan 5...
2018: Parkinson's Disease
Chuan Xu, Jiajun Chen, Xia Xu, Yingyu Zhang, Jia Li
The objective is to search potential therapeutic drugs for Parkinson's disease based on data mining and bioinformatics analysis and providing new ideas for research studies on "new application of conventional drugs." Method differential gene candidates were obtained based on data mining of genes of PD brain tissue, original gene data analysis, differential gene crossover, pathway enrichment analysis, and protein interaction, and potential therapeutic drugs for Parkinson's disease were obtained through drug-gene relationship...
2018: Parkinson's Disease
Alexandre Gironell, Berta Pascual-Sedano, Ignacio Aracil, Juan Marín-Lahoz, Javier Pagonabarraga, Jaime Kulisevsky
Background: The current classification of tremor types in Parkinson disease (PD) is potentially confusing, particularly for mixed tremor, and there is no label for pure resting tremor. With a view to better defining the clinical phenomenological classification of these tremors, our group relabeled the different types as follows: pure resting tremor (type I); mixed resting and action tremor with similar frequencies (type II) divided, according to action tremor presentation, into II-R when there is a time lag and II-C otherwise; pure action tremor (type III); and mixed resting and action tremor with differing frequencies (type IV)...
2018: Parkinson's Disease
Hector R Martinez, Alexis Garcia-Sarreon, Carlos Camara-Lemarroy, Fortino Salazar, María L Guerrero-González
Background: Body motion evaluation (BME) by markerless systems is increasingly being considered as an alternative to traditional marker-based technology because they are faster, simpler, and less expensive. They are increasingly used in clinical settings in patients with movement disorders; however, the wide variety of systems available makes results conflicting. Research Question: The objective of this study was to determine whether a markerless 3D motion capture system is a useful instrument to objectively differentiate between PD patients with DBS in On and Off states and controls and its correlation with the evaluation by means of MDS-UPDRS...
2018: Parkinson's Disease
Yuan Zhang, Li Shu, Xun Zhou, Hongxu Pan, Qian Xu, Jifeng Guo, Beisha Tang, Qiying Sun
Background: GBA gene had been proved to be a crucial gene to the risk of PD. Numerous studies had discussed about the unique clinical characteristics of PD patients with GBA carriers ( GBA  + PD). However, there was lack of updated comprehensive analysis on the topic. In order to clarify the association between GBA variants and the clinical phenotypes of PD, we conducted this comprehensive meta-analysis. Method: Medline, Embase, and Cochrane were used to perform the searching...
2018: Parkinson's Disease
Michaela Karlstedt, Seyed-Mohammad Fereshtehnejad, Dag Aarsland, Johan Lökk
The relationship quality, mutuality, has been identified as a protective factor in family care situations, but its role in mediating health-related quality of life (HRQoL) in patients having Parkinson's disease (PD) is not known. Data on patients' and partners' mutuality (MS), motor signs (UPDRS III), non-motor symptoms (NMSQuest), impaired cognition (IQCODE), dependency in activities of daily life (ADL), and HRQoL (PDQ8) were collected from 51 dyads. Structural equation model with manifest variables was applied to explore if the MS score mediated the effect of UPDRS III, NMSQuest, IQCODE, and dependency in ADL on PDQ8...
2018: Parkinson's Disease
Stefano Gambardella, Rosangela Ferese, Simona Scala, Stefania Carboni, Francesca Biagioni, Emiliano Giardina, Stefania Zampatti, Nicola Modugno, Francesco Fabbiano, Francesco Fornai, Diego Centonze, Stefano Ruggieri
[This corrects the article DOI: 10.1155/2018/5651435.].
2018: Parkinson's Disease
S Coe, M Franssen, J Collett, D Boyle, A Meaney, R Chantry, P Esser, H Izadi, H Dawes
Symptoms of Parkinson's can result in low physical activity and poor sleep patterns which can have a detrimental effect on a person's quality of life. To date, studies looking into exercise interventions for people with Parkinson's (PwP) for symptom management are promising but inconclusive. The aim of this study is to estimate the effect of a clearly defined exercise prescription on general physical activity levels, fatigue, sleep, and quality of life in PwP. Method . PwP randomised into either an exercise group (29; 16 males, 13 females; mean age 67 years (7...
2018: Parkinson's Disease
Minrui Weng, Xiaoji Xie, Chao Liu, Kah-Leong Lim, Cheng-Wu Zhang, Lin Li
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra. The precise mechanism underlying pathogenesis of PD is not fully understood, but it has been widely accepted that excessive reactive oxygen species (ROS) are the key mediator of PD pathogenesis. The causative factors of PD such as gene mutation, neuroinflammation, and iron accumulation all could induce ROS generation, and the later would mediate the dopaminergic neuron death by causing oxidation protein, lipids, and other macromolecules in the cells...
2018: Parkinson's Disease
Luis I Gómez-Jordana, James Stafford, C Lieke E Peper, Cathy M Craig
Studying freezing of gait (FOG) in the lab has proven problematic. This has primarily been due to the difficulty in designing experimental setups that maintain high levels of ecological validity whilst also permitting sufficient levels of experimental control. To help overcome these challenges, we have developed a virtual reality (VR) environment with virtual doorways, a situation known to illicit FOG in real life. To examine the validity of this VR environment, an experiment was conducted, and the results were compared to a previous "real-world" experiment...
2018: Parkinson's Disease
XiaoPing Wang, XiJin Wang, HaiBo Chen, Sarah Duff Canning, Xingguang Luo
No abstract text is available yet for this article.
2018: Parkinson's Disease
Perla Massai, Francesca Colalelli, Julita Sansoni, Donatella Valente, Marco Tofani, Giovanni Fabbrini, Andrea Fabbrini, Michela Scuccimarri, Giovanni Galeoto
Introduction: The Geriatric Depression Scale (GDS) is commonly used to assess depressive symptoms, but its psychometric properties have never been examined in Italian people with Parkinson's disease (PD). The aim of this study was to study the reliability and validity of the Italian version of the GDS in a sample of PD patients. Methods: The GDS was administered to 74 patients with PD in order to study its internal consistency, test-retest reliability, construct, and discriminant validity...
2018: Parkinson's Disease
Anja Ophey, Carsten Eggers, Richard Dano, Lars Timmermann, Elke Kalbe
The most frequently used instrument to assess health-related quality of life (HrQoL) in Parkinson's disease (PD) is the Parkinson's Disease Questionnaire 39 (PDQ-39). However, both the dimensionality of the eight PDQ-39 subscales and their summary score recently faced criticism. Furthermore, data on disease-related and neuropsychological determinants and the role of gender on HrQoL in PD are inconclusive yet. Therefore, our aim was to reevaluate the PDQ-39 structure and to further explore determinants of HrQoL in PD...
2018: Parkinson's Disease
Catharina Sjödahl Hammarlund, Albert Westergren, Ingrid Åström, Anna-Karin Edberg, Peter Hagell
This study explores the impact of living with Parkinson's disease (PD). Nineteen persons (11 women) aged 55-84 diagnosed with PD 3-27 years ago participated. Data were collected through semistructured interviews, which were recorded, transcribed verbatim, and analysed by qualitative content analysis. Four categories represented the impact of living with PD: "Changed prerequisites for managing day-to-day demands," "Loss of identity and dignity," "Compromised social participation," and "The use of practical and psychological strategies...
2018: Parkinson's Disease
Mehmet Sorar, Sahin Hanalioglu, Bilge Kocer, Muhammed Taha Eser, Selim Selcuk Comoglu, Hayri Kertmen
Objective: Deep brain stimulation (DBS) surgery has increasingly been performed for the treatment of movement disorders and is associated with a wide array of complications. We aimed to present our experience and discuss strategies to minimize adverse events in light of this contemporary series and others in the literature. Methods: A retrospective chart review was conducted to collect data on age, sex, indication, operation date, surgical technique, and perioperative and late complications...
2018: Parkinson's Disease
Alon Sinai, Yeshayahu Katz, Menashe Zaaroor, Olga Sandler, Ilana Schlesinger
Ablative incisionless neurosurgery has become possible through advances in focused ultrasound and magnetic resonance imaging (MRI). The great advantage of MRI-guided focused ultrasound (MRgFUS) is that the ablation is performed through an intact skull without surgery. Here, we review the new modality of MRgFUS for treating tremor and enlighten the role of the anesthesiologist in the unique procedural setting of the MRI suite. During the MRgFUS process, the patients should be awake and are required to cooperate with the medical staff to allow assessment of tremor reduction and potential occurrence of adverse effects...
2018: Parkinson's Disease
Wei Di, Zhiyong Zeng, Jingyan Li, Xiaoling Liu, Minzhi Bo, Hua Lv
Numerous studies have investigated the relationship between the LRRK2 G2385R variant and clinical characteristics in Parkinson's disease (PD), but the results have been inconsistent. This study investigated whether the LRRK2 G2385R variant was associated with a unique clinical phenotype of PD in the Asian population, using a meta-analysis. The PubMed, Web of Science, EMBASE, CNKI, and WANFANG databases were searched until September 2017. The strict selection criteria and exclusion criteria were determined, and mean differences (MD) or odds ratios (OR) with 95% confidence intervals (CI) were used to assess the strength of associations...
2018: Parkinson's Disease
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