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Parkinson's Disease

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https://www.readbyqxmd.com/read/29780572/cognitive-training-and-transcranial-direct-current-stimulation-for-mild-cognitive-impairment-in-parkinson-s-disease-a-randomized-controlled-trial
#1
Blake J Lawrence, Natalie Gasson, Andrew R Johnson, Leon Booth, Andrea M Loftus
This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI). Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29780571/apolipoprotein-d-concentration-in-human-plasma-during-aging-and-in-parkinson-s-disease-a-cross-sectional-study
#2
Andreas Waldner, Sarah Dassati, Bernhard Redl, Nicola Smania, Marialuisa Gandolfi
Apolipoprotein D (ApoD), a lipocalin transporter of small hydrophobic molecules, plays an important role in several neurodegenerative diseases. ApoD is expressed in and secreted from a variety of peripheral and brain tissues. Increments of ApoD have been reported in relation with oxidative stress conditions, aging, and degeneration in the nervous system. Preliminary findings support the role of ApoD in neuroprotection. However, its role in PD remains unclear. To date, no studies have been performed on the relationship between ApoD in the blood and PD, as neurodegenerative pathology related to oxidative damage...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29755729/deep-brain-stimulation-in-parkinson-s-disease
#3
EDITORIAL
Raja Mehanna, Hubert H Fernandez, Aparna Wagle Shukla, Jawad A Bajwa
No abstract text is available yet for this article.
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29755728/combination-of-multifocal-electroretinogram-and-spectral-domain-oct-can-increase-diagnostic-efficacy-of-parkinson-s-disease
#4
Jiang Huang, Yi Li, Jianjiang Xiao, Qin Zhang, Guoxu Xu, Guanhui Wu, Tong Liu, Weifeng Luo
Background: The retinal changes have been identified in morphology and function in Parkinson's disease (PD). However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson's disease. The aim of this study was to assess retinal changes and increase the diagnostic efficacy of Parkinson's disease with a combination of multifocal electroretinogram (mf-ERG) and spectral domain optical coherence tomography (SD-OCT) examinations...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29713446/evidence-of-oropharyngeal-dysfunction-in-feeding-in-the-rat-rotenone-model-of-parkinson-s-disease
#5
François D H Gould, Andrew Gross, Rebecca Z German, Jason R Richardson
Swallowing disorders in Parkinson's disease are not responsive to dopamine depletion therapy and contribute to morbidity. They are poorly understood owing to a lack of adequate models. We present the first evidence of oropharyngeal changes in a rotenone toxicity model of Parkinson's disease. Rats were recorded while feeding before and after daily rotenone injections at two different doses (2.75 mg/kg and 3 mg/kg). The higher dose had a much more severe parkinsonian phenotype than the low dose. Timing and amplitude of chewing changed, as did the coordination of chewing and swallowing...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29707191/environmental-and-genetic-variables-influencing-mitochondrial-health-and-parkinson-s-disease-penetrance
#6
REVIEW
Alessandra Zanon, Peter P Pramstaller, Andrew A Hicks, Irene Pichler
There is strong evidence that impairment of mitochondrial function plays a key role in the pathogenesis of PD. The two key PD genes related to mitochondrial function are Parkin ( PARK2 ) and PINK1 ( PARK6 ), and also mutations in several other PD genes, including SNCA , LRRK2 , DJ1 , CHCHD2 , and POLG , have been shown to induce mitochondrial stress. Many mutations are clearly pathogenic in some patients while carriers of other mutations either do not develop the disease or show a delayed onset, a phenomenon known as reduced penetrance...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29686832/patterns-and-predictors-of-depression-treatment-among-older-adults-with-parkinson-s-disease-and-depression-in-ambulatory-care-settings-in-the-united-states
#7
Sandipan Bhattacharjee, Nina Vadiei, Lisa Goldstone, Ziyad Alrabiah, Scott J Sherman
Little is known regarding depression treatment patterns and predictors among older adults with comorbid Parkinson's disease and depression (dPD) in the United States (US). The objective of this study was to assess the patterns and predictors of depression treatment among older adults with dPD in the US. We adopted a cross-sectional study design by pooling multiple-year data (2005-2011) from the National Ambulatory Medical Care Survey (NAMCS) and the outpatient department of the National Hospital Ambulatory Medical Care Survey (NHAMCS)...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29686831/microarray-analysis-of-the-molecular-mechanism-involved-in-parkinson-s-disease
#8
Cheng Tan, Xiaoyang Liu, Jiajun Chen
Purpose: This study aimed to investigate the underlying molecular mechanisms of Parkinson's disease (PD) by bioinformatics. Methods: Using the microarray dataset GSE72267 from the Gene Expression Omnibus database, which included 40 blood samples from PD patients and 19 matched controls, differentially expressed genes (DEGs) were identified after data preprocessing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29535855/prevalence-and-clinical-characteristics-of-probable-rem-behavior-disorder-in-thai-parkinson-s-disease-patients
#9
Patama Gomutbutra, Kittika Kanjanaratanakorn, Nantaporn Tiyapun
Background: Previous studies have shown that Parkinson's disease (PD) patients who have REM behavior disorder (PD with RBD) might be a PD subtype since they have different symptom clusters and disease trajectories from PD without RBD. Objective: To study the prevalence of PD with pRBD and to compare the clinical characteristics with PD without pRBD. The feasibility of clinical interview of items adopted from the Mayo Sleep Questionnaire was also to be determined...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29535854/clock-3111t-c-variant-correlates-with-motor-fluctuation-and-sleep-disorders-in-chinese-patients-with-parkinson-s-disease
#10
Fan Lou, Ming Li, Xiaoguang Luo, Yan Ren
Background: The clock genes controlling biological rhythm play an important role in the pathophysiology of aging. The purpose of this study was to determine whether there is an association between a variant of the circadian locomotor output cycles kaput (CLOCK) gene and circadian dysfunction of Parkinson's disease (PD). Methods: Six hundred and forty-six cases of Parkinson's disease from consecutive outpatients and inpatients ward from our hospital were included in this study...
2018: Parkinson's Disease
https://www.readbyqxmd.com/read/29359066/theatre-is-a-valid-add-on-therapeutic-intervention-for-emotional-rehabilitation-of-parkinson-s-disease-patients
#11
Giovanni Mirabella, Paolo De Vita, Michele Fragola, Silvia Rampelli, Francesco Lena, Fulvia Dilettuso, Marta Iacopini, Raffaella d'Avella, Maria Concetta Borgese, Silvia Mazzotta, Deborah Lanni, Marco Grano, Sara Lubrani, Nicola Modugno
Conventional medical treatments of Parkinson's disease (PD) are effective on motor disturbances but may have little impact on nonmotor symptoms, especially psychiatric ones. Thus, even when motor symptomatology improves, patients might experience deterioration in their quality of life. We have shown that 3 years of active theatre is a valid complementary intervention for PD as it significantly improves the well-being of patients in comparison to patients undergoing conventional physiotherapy. Our aim was to replicate these findings while improving the efficacy of the treatment...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29359065/cognitive-impact-of-deep-brain-stimulation-on-parkinson-s-disease-patients
#12
REVIEW
Raja Mehanna, Jawad A Bajwa, Hubert Fernandez, Aparna Ashutosh Wagle Shukla
Subthalamic nucleus (STN) or globus pallidus interna (GPi) deep brain stimulation (DBS) is considered a robust therapeutic tool in the treatment of Parkinson's disease (PD) patients, although it has been reported to potentially cause cognitive decline in some cases. We here provide an in-depth and critical review of the current literature regarding cognition after DBS in PD, summarizing the available data on the impact of STN and GPi DBS as monotherapies and also comparative data across these two therapies on 7 cognitive domains...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29333317/phosphorylated-%C3%AE-synuclein-copper-complex-formation-in-the-pathogenesis-of-parkinson-s-disease
#13
REVIEW
Juan Antonio Castillo-Gonzalez, Maria De Jesus Loera-Arias, Odila Saucedo-Cardenas, Roberto Montes-de-Oca-Luna, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha
Parkinson's disease is the second most important neurodegenerative disorder worldwide. It is characterized by the presence of Lewy bodies, which are mainly composed of α -synuclein and ubiquitin-bound proteins. Both the ubiquitin proteasome system (UPS) and autophagy-lysosomal pathway (ALS) are altered in Parkinson's disease, leading to aggregation of proteins, particularly α -synuclein. Interestingly, it has been observed that copper promotes the protein aggregation process. Additionally, phosphorylation of α -synuclein along with copper also affects the protein aggregation process...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29333316/impact-of-m%C3%A3-zi%C3%A3-res-rehabilitative-method-in-patients-with-parkinson-s-disease-a-randomized-controlled-trial
#14
Teresa Paolucci, Federico Zangrando, Giulia Piccinini, Laura Deidda, Rossella Basile, Enrico Bruno, Emigen Buzi, Alice Mannocci, Franca Tirinelli, Shalom Haggiag, Ludovico Lispi, Ciro Villani, Vincenzo M Saraceni
The aim of this study was to assess the efficacy of Mézières method in improving trunk flexibility of the back muscles and balance in patients with Parkinson's disease (PD). Materials and Methods . Thirty-six patients were randomized into 2 groups: the Mézières treatment group and the control group (home exercise group). The primary outcome was the improvement in balance per the Berg Balance Scale (BBS) and the trunk flexibility of the back for the anterior flexion trunk test. Also, we evaluated pain, gait balance for the Functional Gait Assessment (FGA), disease-related disability for the Modified Parkinson's Activity Scale and the Unified Parkinson's Disease Rating Scale (UPDRS), the quality of life, and the functional exercise capacity...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29214093/should-skin-biopsies-be-performed-in-patients-suspected-of-having-parkinson-s-disease
#15
REVIEW
Timo Siepmann, Ana Isabel Penzlin, Ben Min-Woo Illigens, Heinz Reichmann
In patients with Parkinson's disease (PD), the molecularly misfolded form of α -synuclein was recently identified in cutaneous autonomic nerve fibers which displayed increased accumulation even in early disease stages. However, the underlying mechanisms of synucleinopathic nerve damage and its implication for brain pathology in later life remain to be elucidated. To date, specific diagnostic tools to evaluate small fiber pathology and to discriminate neurodegenerative proteinopathies are rare. Recently, research has indicated that deposition of α -synuclein in cutaneous nerve fibers quantified via immunohistochemistry in superficial skin biopsies might be a valid marker of PD which could facilitate early diagnosis and monitoring of disease progression...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29209554/genetic-analysis-of-lrrk2-r1628p-in-parkinson-s-disease-in-asian-populations
#16
REVIEW
Yuan Zhang, Qiying Sun, Minhan Yi, Xun Zhou, Jifeng Guo, Qian Xu, Beisha Tang, Xinxiang Yan
Although the etiology of Parkinson's disease (PD) remains unclear, there is increasing evidence of genetic factors contributing to the onset of PD. Various mutations and risk variants of the gene LRRK2 have been reported, but the association between LRRK2 R1628P and PD is still inconsistent. Thus, we conducted a meta-analysis to determine the potential relationship between R1628P and PD. Our study sample was an aggregate of 17 publications, which in total consisted of 9,275 PD patients and 8,114 controls. All of these articles are of high quality according to NOS, and there was no obvious reporting bias or heterogeneity...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29209553/antidyskinetic-treatment-with-mtep-affects-multiple-molecular-pathways-in-the-parkinsonian-striatum
#17
Jing-Ya Lin, Zhen-Guo Liu, Cheng-Long Xie, Lu Song, Ai-Juan Yan
Parkinson's disease is characterized by dopaminergic neuron loss and dopamine (DA) depletion in the striatum. Standard treatment is still focused on the restoration of dopamine with exogenous L-Dopa, which however causes L-Dopa-induced dyskinesia (LID). Several studies have shown that antagonism of the metabotropic glutamate receptor 5 alleviates LID, but the underlying mechanisms have remained unclear. We set out to determine where this alleviation may depend on restoring the equilibrium between the two main striatofugal pathways...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29158943/depression-in-parkinson-s-disease-the-contribution-from-animal-studies
#18
REVIEW
Jéssica Lopes Fontoura, Camila Baptista, Flávia de Brito Pedroso, José Augusto Pochapski, Edmar Miyoshi, Marcelo Machado Ferro
Besides being better known for causing motor impairments, Parkinson's disease (PD) can also cause many nonmotor symptoms, like depression and anxiety, which can cause significant loss of life quality and may not respond to regular drugs treatment. In this review, we discuss the depression in PD, based on data from studies in humans and rodents. Depression frequency seems higher in PD patients than in general population, despite high variation in data due to diagnosis disparities. Development of depression in PD seems more likely to be caused by the nigrostriatal pathway degeneration than as a consequence of the awareness of disease prognostic, and it seems to be related to dopaminergic, noradrenergic, and serotoninergic synapses deficits...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29158942/the-single-nucleotide-polymorphism-rs1014290-of-the-slc2a9-gene-is-associated-with-uric-acid-metabolism-in-parkinson-s-disease
#19
Jiangfang Miao, Jing Liu, Li Xiao, Jiedi Zheng, Chunfeng Liu, Zufu Zhu, Kai Li, Weifeng Luo
Individuals with Parkinson's disease (PD) have lower uric acid levels than those without PD, and the CC genotype and C minor allele of a single nucleotide polymorphism (SNP), rs1014290 of SLC2A9 , are associated with lower uric acid levels. We investigated the association of rs1014290 with uric acid metabolism in a cohort of PD cases (220) and controls (110) in a Han Chinese population. Uric acid levels were determined and rs1014290 was assayed using a mutation-sensitive on/off switch technology. PD uric acid levels (291...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/29147598/dbs-programming-an-evolving-approach-for-patients-with-parkinson-s-disease
#20
REVIEW
Aparna Wagle Shukla, Pam Zeilman, Hubert Fernandez, Jawad A Bajwa, Raja Mehanna
Deep brain stimulation (DBS) surgery is a well-established therapy for control of motor symptoms in Parkinson's disease. Despite an appropriate targeting and an accurate placement of DBS lead, a thorough and efficient programming is critical for a successful clinical outcome. DBS programming is a time consuming and laborious manual process. The current approach involves use of general guidelines involving determination of the lead type, electrode configuration, impedance check, and battery check. However there are no validated and well-established programming protocols...
2017: Parkinson's Disease
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