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Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders

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https://www.readbyqxmd.com/read/30242612/pediatric-insulin-injection-technique-a-multi-country-survey-and-clinical-practice-implications
#1
Sanjay Kalra, Laurence J Hirsch, Anders Frid, Asthma Deeb, Kenneth W Strauss
INTRODUCTION: The 2015 Insulin Injection Technique Questionnaire survey involving 13,289 patients included 898 (6.8%) patients in the pediatric age range (≤ 18 years). METHODS: The younger patients included in the questionnaire survey were grouped according to age: Group 1 (G1), 0-6 years, n = 85; Group 2(G2), 7-13, n = 423; Group 3 (G3), 14-18, n = 390. The injection technique was evaluated by means of a questionnaire and nurse assessment. RESULTS: Nurses found lipohypertrophy at injection sites in 41...
September 21, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30242611/impact-of-insulin-degludec-in-type-2-diabetes-real-world-data-on-effectiveness-and-safety
#2
Paola Ponzani, Cesare Berra, Alessandra Di Lelio, Paola Del Sindaco, Chiara Di Loreto, Francesco Reggiani, Giuseppe Lucisano, Maria Chiara Rossi
INTRODUCTION: Real-world evidence on effectiveness and safety of insulin degludec (IDeg) in patients with diabetes is a priority. The aim of the study was to evaluate patterns of use and the long-term effectiveness and safety of IDeg in routine clinical practice. METHODS: This was an observational longitudinal study. A retrospective chart review of all patients with type 2 diabetes treated with IDeg was performed and temporal trends in clinical outcomes were assessed...
September 21, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30238228/clinical-impact-of-5-years-of-liraglutide-treatment-on-cardiovascular-risk-factors-in-patients-with-type-2-diabetes-mellitus-in-a-real-life-setting-in-italy-an-observational-study
#3
Vera Frison, Natalino Simioni, Alberto Marangoni, Sara Balzano, Carmela Vinci, Luciano Zenari, Lorena De Moliner, Federica Tadiotto, Michele D'Ambrosio, Loris Confortin, Narciso Marin, Simonetta Lombardi, Silvana Costa, Giuseppe Prosperini, Annunziata Lapolla
INTRODUCTION: Based on existing data regarding the durability of liraglutide in type 2 diabetes, this study aimed to assess its long-term effectiveness at 5 years and its overall impact on cardiovascular (CV) risk. METHODS: This was a multicenter retrospective observational study. Liraglutide was used under routine clinical practice conditions. Changes from baseline to 60 months in HbA1c, fasting plasma glucose (FPG), body weight, blood pressure, and lipid profile were assessed...
September 20, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30229443/a-prospective-cohort-study-on-the-management-of-young-patients-with-newly-diagnosed-type-2-diabetes-using-mobile-medical-applications
#4
Yabin Hao, Hong Xu
INTRODUCTION: The aim of this study was to evaluate the effect of using a mobile medical application (app) for self-monitoring of blood glucose (SMBG) and blood glucose control in young patients with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: This was a prospective cohort study involving young patients with newly diagnosed T2DM. On a voluntary basis, the patients chose to be included in a group in which they were followed up for 24 weeks with a mobile medical app and the changes in laboratory data and frequency of SMBG observed via the app, or in a group in which they received traditional medical treatment and follow-up...
September 18, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30220039/reassessing-coronary-artery-bypass-surgery-versus-percutaneous-coronary-intervention-in-patients-with-type-2-diabetes-mellitus-a-brief-updated-analytical-report-2015-2017
#5
Xia Dai, Zu-Chun Luo, Lu Zhai, Wen-Piao Zhao, Feng Huang
INTRODUCTION: In this analysis, we aimed to systematically compare percutaneous coronary intervention (PCI) versus coronary artery bypass surgery (CABG) in terms of adverse outcomes utilizing data from a recent (2015-2017) population of patients with type 2 diabetes mellitus (T2DM). METHODS: An electronic search of recent studies (2015-2017) was carried out using 'diabetes mellitus,' 'coronary artery bypass surgery,' and 'percutaneous coronary intervention' as the main search terms...
September 15, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30220038/continuous-subcutaneous-insulin-infusion-characteristics-in-type-1-diabetes-children-and-adolescents-in-qatar
#6
Goran Petrovski, Fawziya Al Khalaf, Khalid Hussain, Judith Campbell, Ahmed El Awwa
AIM: To describe continuous subcutaneous insulin infusion (CSII) characteristics in type 1 diabetes mellitus (T1DM) children and adolescents using a standardized protocol in routine clinical settings in Qatar. METHODS: A total of 138 T1DM patients (62 males; 76 females; mean age 9.8 ± 3.4 years) with a mean diabetes duration of 2.4 ± 1.9 years initiated CSII (MiniMed® Veo® ™ and MiniMed® 640 G insulin pumps; Medtronic, Northridge, CA, USA) in 2016 and 2017...
September 15, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30218434/bedtime-to-morning-glucose-difference-and-iglarlixi-in-type-2-diabetes-post-hoc-analysis-of-lixilan-l
#7
Ariel Zisman, Terry Dex, Michelle Roberts, Aramesh Saremi, Jason Chao, Vanita R Aroda
INTRODUCTION: A difference of ≥ 50-55 mg/dL between bedtime and morning glucose (BeAM) values in patients with type 2 diabetes (T2D) on basal insulin is an indicator of poor postprandial glucose control. This analysis compared the effect of treatment with a fixed-ratio combination of insulin glargine/lixisenatide (iGlarLixi) vs insulin glargine (iGlar) on BeAM values, and evaluated the impact of BeAM values on glycemic and safety endpoints. METHODS: In this post hoc analysis of 517 participants from the LixiLan-L trial, change in BeAM values and composite efficacy and safety endpoints stratified by BeAM value < 55 mg/dL or ≥ 55 mg/dL were evaluated in patients with T2D uncontrolled on basal insulin randomized to iGlarLixi or iGlar over 30 weeks (LixiLan-L)...
September 14, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30218433/diabetes-and-diet-a-patient-and-dietitian-s-perspective
#8
Carole Sergeant, Pamela A Dyson
This article has been co-authored by a patient with type 2 diabetes and a specialist dietitian. Here they discuss the patient's experience and difficulties with controlling weight and strategies that can help a patient in this situation. The patient discusses how stress and her corresponding comfort eating dampened weight loss progress, and how adopting a lifestyle change aided through group support helped to deal with this. The physician discusses the importance of recognizing the mental and physical challenges faced by patients in this situation...
September 14, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30218432/improved-treatment-engagement-among-patients-with-diabetes-treated-with-insulin-glargine-300-u-ml-who-participated-in-the-coach-support-program
#9
Jennifer D Goldman, Jasvinder Gill, Tony Horn, Timothy Reid, Jodi Strong, William H Polonsky
INTRODUCTION: Persistence with basal insulin therapy can be suboptimal, despite recent improvements in insulin formulations and delivery systems. Patient support programs may help increase adherence. This study evaluated the impact of the Toujeo® COACH support program, which provides patients with continuing and individualized education and advice on lifestyle changes, by assessing its effect on number of refills and days on therapy. METHODS: The study population included 1724 patients with diabetes who filled a first prescription for insulin glargine 300 U/mL (Gla-300) between April and December 2015 and received a welcome call from a Guide, and 1724 matched control patients from the Symphony Health Integrated Dataverse® prescription claims database...
September 14, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30209797/metabolic-control-in-type-1-diabetes-is-adjunctive-therapy-the-way-forward
#10
REVIEW
Harriet Warnes, Rebecca Helliwell, Sam Matthew Pearson, Ramzi A Ajjan
Despite advances in insulin therapies, patients with type 1 diabetes (T1DM) have a shorter life span due to hyperglycaemia-induced vascular disease and hypoglycaemic complications secondary to insulin therapy. Restricting therapy for T1DM to insulin replacement is perhaps an over-simplistic approach, and we focus in this work on reviewing the role of adjuvant therapy in this population. Current data suggest that adding metformin to insulin therapy in T1DM temporarily lowers HbA1c and reduces weight and insulin requirements, but this treatment fails to show a longer-term glycaemic benefit...
September 12, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30206904/association-of-vitamin-d-and-parathyroid-hormone-with-insulin-sensitivity-beta-cell-function-and-gestational-diabetes-in-pregnancy-a-cross-sectional-observational-study
#11
Amit Nachankar, Narendra Kotwal, Vimal Upreti, Vishesh Verma, K V S Hari Kumar
INTRODUCTION: Vitamin D (25OHD) and parathyroid hormone (PTH) are associated with dysglycemia, and we investigated them in gestational diabetes mellitus (GDM). METHODS: In this cross-sectional, observational study, we included 75 pregnant women between 24 and 28 weeks of gestation. A fasting venous sample was collected for plasma glucose (FPG), insulin, PTH and 25OHD. Glucose and insulin samples were collected hourly after 75 g glucose load for 2 h. Insulin sensitivity was estimated by the Matsuda index (MI) and beta cell function by the insulin secretion sensitivity index (ISSI-2)...
September 11, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30206903/comprehensive-evaluation-of-combination-therapy-with-basal-insulin-and-either-lixisenatide-or-vildagliptin-in-japanese-patients-with-type-2-diabetes-a-randomized-open-label-parallel-group-multicenter-study
#12
Natsu Otowa-Suematsu, Kazuhiko Sakaguchi, Tomoaki Nakamura, Kenta Hara, Minoru Kishi, Naoko Hashimoto, Kazuki Yokota, Hiroshi Yoshino, Yasuo Kuroki, Tomoko Nishiumi, Anna Sou, Hisako Komada, Yuko Okada, Yushi Hirota, Yoshikazu Tamori, Wataru Ogawa
INTRODUCTION: We comprehensively evaluated the effects of combination therapy with insulin glargine and the incretin-based drugs lixisenatide or vildagliptin in Japanese patients with type 2 diabetes. METHODS: In this 12-week, randomized, open-label, parallel-group, multicenter study (GLP-ONE Kobe), the incretin-based drug sitagliptin was randomly switched to lixisenatide (20 μg/day, n = 18) or vildagliptin (100 mg/day, n = 20) in patients with inadequate glycemic control despite combination therapy with insulin glargine and sitagliptin...
September 11, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30206902/blood-glucose-monitoring-and-its-determinants-in-diabetic-patients-a-cross-sectional-study-in-shandong-china
#13
Abdul Marouf Raoufi, Xue Tang, Zhengyue Jing, Xinyi Zhang, Qiongqiong Xu, Chengchao Zhou
INTRODUCTION: The aim of this study was to explore the status of blood glucose monitoring and its determinants in diabetic patients in Shandong Province, China. METHODS: This was a cross-sectional survey conducted from 31 August to 12 October 12, in Shandong Province. A multi-stage stratified cluster sampling method was used to select participants. A total of 2183 diabetic patients were included in the analysis. Frequencies and proportions were used to describe the data, and multiple binary logistic regressions were performed to determine factors associated with blood glucose monitoring...
September 11, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30203238/association-of-patient-profile-with-glycemic-control-and-hypoglycemia-with-insulin-glargine-300-u-ml-in-type-2-diabetes-a-post-hoc-patient-level-meta-analysis
#14
Stephen M Twigg, Javier Escalada, Peter Stella, Ana Merino-Trigo, Fernando J Lavalle-Gonzalez, Bertrand Cariou, Luigi F Meneghini
AIMS: To examine the association of baseline patient characteristics with study outcomes in people with type 2 diabetes receiving insulin glargine 300 U/mL (Gla-300) versus glargine 100 U/mL (Gla-100), over a 6-month period. METHODS: A post hoc patient-level meta-analysis using data from three multicenter, randomized, open-label, parallel-group, phase 3a studies of similar design, in people previously receiving either basal and prandial insulin, basal insulin + oral antihyperglycemic drugs, or no prior insulin (EDITION 1, 2 and 3, respectively)...
September 10, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30191537/living-with-type-2-diabetes-patient-commentary-in-response-to-the-paper-sglt2-inhibitors-in-type-2-diabetes-management-key-evidence-and-implications-for-clinical-practice
#15
LETTER
Marc Evans
This article, co-authored by a patient living with type 2 diabetes and a diabetes specialist physician, discusses the patient's experience of living with type 2 diabetes, including their experience of diagnosis and self-management, education and adoption of SGLT2 inhibitors to treat the disease. The physician discusses the therapeutic challenges of SGLT2 inhibitors and the importance of education. FUNDING: Napp Pharmaceuticals, Ltd.
September 6, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30187227/impact-of-glucose-measuring-systems-and-sample-type-on-diagnosis-rates-of-diabetes-mellitus
#16
Markus Gabriel Blaurock, Anders Kallner, Stefan Menzel, Annette Masuch, Matthias Nauck, Astrid Petersmann
INTRODUCTION: The use of glucose point-of-care testing (POCT) devices for the diagnosis of diabetes mellitus (DM) is an ongoing controversy. In patient management, glucose concentrations are determined by POCT and core laboratory glucose methods, and the values are commonly compared even though the samples collected are different, namely, capillary whole blood and venous plasma. In individual patients it is difficult to distinguish between factors that can influence the results, such as sample type and measuring procedure...
September 5, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30171589/could-intensive-blood-pressure-control-really-reduce-diabetic-retinopathy-outcomes-evidence-from-meta-analysis-and-trial-sequential-analysis-from-randomized-controlled-trials
#17
Jian-Bo Zhou, Zhi-Hui Song, Lu Bai, Xiao-Rong Zhu, Hong-Bing Li, Jin-Kui Yang
INTRODUCTION: To explore the accumulated evidence concerning the effect of intensive blood pressure control on the incidence and progression of diabetic retinopathy (DR), proliferative diabetic retinopathy (PDR) and macular edema (ME). METHODS: A number of electronic databases were searched including PubMed, EMBASE, CINAHL, Cochrane Library, conferences and proceedings. Randomized controlled trials comparing intensive blood pressure targets with conventional blood pressure targets in patients with type 2 diabetes were included...
August 31, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30168045/long-term-effects-of-oral-antidiabetic-drugs-during-pregnancy-on-offspring-a-systematic-review-and-meta-analysis-of-follow-up-studies-of-rcts
#18
REVIEW
Wenneke van Weelden, Vincent Wekker, Leon de Wit, Jacqueline Limpens, Hilkka Ijäs, Aleid G van Wassenaer-Leemhuis, Tessa J Roseboom, Bas B van Rijn, J Hans DeVries, Rebecca C Painter
INTRODUCTION: Antidiabetic drugs (OADs) are increasingly prescribed to treat hyperglycaemia during pregnancy in women with gestational diabetes mellitus (GDM) or polycystic ovary syndrome (PCOS), even though long-term effects on offspring are unknown. This systematic review summarises the evidence of follow-up studies of randomised controlled trials (RCTs) reporting on long-term effects of prenatal exposure to OADs on offspring. METHODS: The MEDLINE, EMBASE and CENTRAL databases were searched from inception to April 2018 for the concepts antidiabetic agents and prenatal exposure (or pregnancy and offspring/child) in combination with an RCT search filter...
August 30, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30155646/efficacy-and-safety-of-initial-combination-therapy-in-treatment-na%C3%A3-ve-type-2-diabetes-patients-a-systematic-review-and-meta-analysis
#19
Xiaoling Cai, Xueying Gao, Wenjia Yang, Xueyao Han, Linong Ji
INTRODUCTION: The aim of this study was to evaluate the efficacy and safety of initial combination therapy compared with monotherapy in drug-naïve type 2 diabetes patients. METHODS: MEDLINE, Embase and the Cochrane Central Register of Controlled Trials were searched for randomized clinical trials of initial combination therapy with hypoglycemic agents compared with monotherapy. Those which satisfied the search criteria were included in the meta-analysis. Weighted mean difference and relative risks were calculated...
August 28, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30145651/rationale-and-design-of-the-stop-ob-study-for-evaluating-the-effects-of-tofogliflozin-and-glimepiride-on-fat-deposition-in-type-2-diabetes-patients-treated-with-metformin-dpp-4-inhibitor-dual-therapy
#20
Hisamitsu Ishihara, Motonobu Anai, Hiroaki Seino, Toru Kitazawa, Hiroshi Ohashi, Masumi Ai, Masahiro Inoue, Midori Fujishiro, Takeshi Inazawa, Hisamoto Kuroda, Masayo Yamada
BACKGROUND: The global pandemic of type 2 diabetes mellitus (T2DM) is an enormous clinical and socioeconomic burden. Biguanides and DPP-4 inhibitors (DPP-4i) are the most commonly used therapies in Japanese T2DM patients. When glycemic control is not adequate despite combination of these drugs, there is no consensus on the next step drug. Systematic reviews and meta-analyses of previous trials have indicated that glycemic control with triple combination therapies yields similar results...
August 25, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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