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Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders

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https://www.readbyqxmd.com/read/30430366/incidence-of-diabetes-in-the-working-population-in-spain-results-from-the-icaria-cohort
#1
Luis Alberto Vazquez, Eva Calvo-Bonacho, Jesús Reviriego, Teresa García-Margallo, Elena Caveda, Albert Goday
INTRODUCTION: Our objective was to evaluate the incidence of type 2 diabetes mellitus (T2DM) in a working population in Spain and to assess associations between its development and several risk factors. METHODS: The ICARIA (Ibermutuamur CArdiovascular RIsk Assessment) cohort (n = 627,523) includes ~3% of Spanish workers. This analysis was undertaken in individuals whose glycaemic status during the index period (May 2004-December 2007) was determined to be normal or indicative of prediabetes [fasting plasma glucose (FPG) 100-125 mg/dl] and who had at least one FPG measurement taken 9 months after a first measurement during follow-up (May 2004-June 2014) (n = 380,366)...
November 14, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30392095/liraglutide-and-glycaemic-outcomes-in-the-leader-trial
#2
Bernard Zinman, Michael A Nauck, Heidrun Bosch-Traberg, Helle Frimer-Larsen, David D Ørsted, John B Buse
INTRODUCTION: The LEADER trial was a cardiovascular (CV) outcomes trial in patients with type 2 diabetes at high CV risk that compared liraglutide (n = 4668) with placebo (n = 4672) using a primary composite endpoint of 3-point major adverse CV events. The objective of this post hoc analysis was to investigate glycaemic outcomes across both treatment groups. METHODS: Glycated haemoglobin (HbA1c ) was measured at randomisation, month 3, month 6 and every 6 months thereafter...
November 3, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30390228/expert-opinion-patient-selection-for-premixed-insulin-formulations-in-diabetes-care
#3
REVIEW
Sanjay Kalra, Leszek Czupryniak, Gary Kilov, Roberta Lamptey, Ajay Kumar, A G Unnikrishnan, Aissa Boudiba, Mohamed Abid, Zhanay A Akanov, Ali Latheef, Mustafa Araz, Ralph Audehm, Silver Bahendeka, Naby Balde, Sandeep Chaudhary, Chaicharn Deerochanawong, Olufemi Fasanmade, Hinde Iraqi, Tint Swe Latt, Jean Claude Mbanya, Joel Rodriguez-Saldana, Ko Seung Hyun, Zafar A Latif, Maxim Lushchyk, Magdy Megallaa, Mohammed Wali Naseri, Nguyen Quang Bay, Kaushik Ramaiya, Hoosen Randeree, Syed Abbas Raza, Khalid Shaikh, Dina Shrestha, Eugene Sobngwi, Noel Somasundaram, Norlela Sukor, Rima Tan
Premixed insulins are an important tool for glycemic control in persons with diabetes. Equally important in diabetes care is the selection of the most appropriate insulin regimen for a particular individual at a specific time. Currently, the choice of insulin regimens for initiation or intensification of therapy is a subjective decision. In this article, we share insights, which will help in rational and objective selection of premixed formulations for initiation and intensification of insulin therapy. The glycemic status and its variations in a person help to identify the most appropriate insulin regimen and formulation for him or her...
November 3, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30390227/effect-of-intravitreal-bevacizumab-with-or-without-macular-photocoagulation-for-diabetic-macular-edema-a-meta-analysis
#4
Kang Xiao, Shi-Jia Weng, Shen-Zhi Liang, Jiong Wang, Cheng Qian, Guang-Ming Wan
INTRODUCTION: In this meta-analysis, we aimed to assess the possible benefits of macular photocoagulation (MPC) as an additional treatment with intravitreal bevacizumab (IVB) in patients with diabetic macular edema. METHODS: The studies were identified from three databases: PubMed, Web of Science, and the Cochrane Library. The main outcome measures included change in best-corrected visual acuity (BCVA), differences in central macular thickness (CMT), and adverse events within the follow-up period...
November 2, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30377996/insulin-injection-technique-in-china-compared-with-the-rest-of-the-world
#5
Zhenqiang Song, Xiaohui Guo, Linong Ji, Xiao Huang, Laurence J Hirsch, Kenneth W Strauss
INTRODUCTION: Approximately 9 million people in China use insulin but little is known of their injection techniques (IT). Our aim was to understand IT in China via direct examination and a detailed survey. METHODS: Injection Technique Questionnaire (ITQ) results of 3853 patients from 20 representative centers in China were compared with the Rest of World (ROW). RESULTS: Insulin pens are used by 92% of Chinese insulin injectors, with > 3/4 using 4- or 5-mm pen needles...
October 30, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30377995/concentrations-of-vegf-and-plgf-decrease-in-eyes-after-intravitreal-conbercept-injection
#6
Jun Zhou, Zheng Liu, Meng Chen, Zhi-Heng Luo, Yun-Qiu Li, Guang-Ying Qi, Tao Liu
INTRODUCTION: Conbercept is a new anti-vascular endothelial growth factor drug approved for the treatment of age-related macular degeneration by the China Food and Drug Administration (CFDA) in 2013. In this study, we for the first time evaluated the concentrations of vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) after patients with proliferative diabetic retinopathy were treated with intravitreal conbercept (IVC) injection. METHODS: Sixteen patients with proliferative diabetic retinopathy were randomly divided into two equal groups (A and B)...
October 30, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30374708/correction-to-pediatric-insulin-injection-technique-a-multi-country-survey-and-clinical-practice-implications
#7
Sanjay Kalra, Laurence J Hirsch, Anders Frid, Asma Deeb, Kenneth W Strauss
In the original publication, fourth author name was incorrectly published as Asthma Deeb in author group.
October 29, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30341665/effects-of-insulin-degludec-and-insulin-glargine-u300-on-day-to-day-fasting-plasma-glucose-variability-in-individuals-with-type-1-diabetes-a-multicenter-randomized-crossover-study-kobe-best-basal-insulin-study-2
#8
Hiroshi Miura, Kazuhiko Sakaguchi, Yuko Okada, Natsu Otowa-Suematsu, Tomoko Yamada, Anna So, Hisako Komada, Yushi Hirota, Minoru Kishi, Akihiko Takeda, Yoichi Tominaga, Tomoaki Nakamura, Yasuo Kuroki, Tomokazu Matsuda, Keiji Iida, Michiko Kajikawa, Takeshi Ohara, Kazuki Yokota, Kenta Hara, Sanshiro Tateya, Yoshikazu Tamori, Wataru Ogawa
INTRODUCTION: Administered basal insulin markedly influences the fasting plasma glucose (FPG) level of individuals with type 1 diabetes. Insulin degludec (IDeg) and insulin glargine U300 (IGlar U300) are now available as ultra-long-acting insulin formulations, but whether or how their glucose-stabilizing effects differ remains unclear. We will compare the effects of these basal insulins on parameters related to blood glucose control, with a focus on day-to-day glycemic variability, in individuals with type 1 diabetes treated with multiple daily injections...
October 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30341664/insulin-injection-technique-is-associated-with-glycemic-variability-in-patients-with-type-2-diabetes
#9
Lu Yuan, Fengfei Li, Ting Jing, Bo Ding, Yong Luo, Rui Sun, Xiuping Wang, Hefeng Diao, Xiaofei Su, Lei Ye, Jianhua Ma
INTRODUCTION: Patients with type 2 diabetes (T2D) receiving premixed insulin often fail to achieve optimal glycemic control. The insulin injection technique (IT) itself may be one of the factors affecting glycemic variability (GV). The aim of this study was to assess the relationship between GV and IT in patients with T2D using premixed insulin. METHODS: This was a single center, cross-sectional, and self-controlled trial. Patients with T2D using premixed insulin were enrolled as inpatients...
October 19, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30302722/correlation-between-different-stages-of-diabetic-nephropathy-and-neuropathy-in-patients-with-t2dm-a-cross-sectional-controlled-study
#10
Lingling Xu, Xiaopu Lin, Meiping Guan, Yingshan Liu
INTRODUCTION: Early detection of diabetic peripheral neuropathy (DPN) is critical in patients with type 2 diabetes mellitus (T2DM) due to the lack of targeted therapy for DPN. We have investigated the relationship between different stages of diabetic nephropathy and DPN in an attempt to elucidate whether albuminuria can be used as an early warning signal of DPN progression. METHODS: A total of 217 T2DM patients who met the inclusion criteria were recruited from the Department of Endocrinology, Nanfang Hospital between January 2016 and June 2016...
October 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30302721/improved-glycemic-control-with-insulin-glargine-300-u-ml-toujeo-%C3%A2-in-patients-with-type-2-diabetes-real-world-effectiveness-in-switzerland
#11
Peter Wiesli, Marcus Schories
INTRODUCTION: Insulin glargine 300 U/mL (Gla-300, Toujeo® ) is a long-acting, once-daily basal insulin with improved-more stable and smoother-pharmacokinetic and pharmacodynamic profiles compared to insulin glargine 100 U/mL (Gla-100) and insulin degludec (IDeg). These properties have been shown to translate into an effective HbA1c reduction with the advantage of a lower risk of hypoglycemia in randomized controlled trials of Gla-300 versus Gla-100. In this study, we assessed the effectiveness and safety of Gla-300 under real-world conditions in Switzerland...
October 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30298444/glucagon-like-peptide-1-infusion-suppresses-aldosterone-levels-in-healthy-normal-weight-individuals-double-blind-placebo-controlled-crossover-study
#12
Maja Baretić, Vesna Kušec, Ivana Pavlić-Renar
INTRODUCTION: Glucagon-like peptide-1 (GLP-1) has many effects on the human body, but its glucose-lowering effect through its stimulation of insulin secretion is the most significant. GLP-1 also acts on renal function and hemodynamics. The antihypertensive and renoprotective effects of GLP-1 receptor agonists are partly explained by their vasoactive effect and increased natriuresis, but their positive influences on blood pressure and the development and progression of kidney disease are attributed to many effects beyond glycemic control...
October 8, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30293159/correction-to-reassessing-coronary-artery-bypass-surgery-versus-percutaneous-coronary-intervention-in-patients-with-type-2-diabetes-mellitus-a-brief-updated-analytical-report-2015-2017
#13
Xia Dai, Zu-Chun Luo, Lu Zhai, Wen-Piao Zhao, Feng Huang
In the original publication, conclusion was incorrectly updated in the article main text. The complete statement is given below.
October 6, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30288700/intravitreal-ranibizumab-therapy-for-diabetic-macular-edema-in-routine-practice-two-year-real-life-data-from-a-non-interventional-multicenter-study-in-germany
#14
Focke Ziemssen, Joachim Wachtlin, Laura Kuehlewein, Maria-Andreea Gamulescu, Thomas Bertelmann, Nikolaus Feucht, Jessica Voegeler, Mirja Koch, Sandra Liakopoulos, Steffen Schmitz-Valckenberg, Georg Spital
INTRODUCTION: The prospective, non-interventional OCEAN study examined the use of intravitreal ranibizumab injections for the treatment of diabetic macular oedema (DME) in a real-world setting in Germany. METHODS: Adults with DME receiving ≥ 1 ranibizumab (0.5 mg) injections were recruited by 250 ophthalmologists. Best-corrected visual acuity (VA) testing, imaging and treatments were performed according to the investigators' routine practice and documented over 24 months...
October 4, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30284689/investigating-the-reliability-of-hba1c-monitoring-for-blood-glucose-control-during-late-pregnancy-in-patients-with-gestational-diabetes-mellitus-gdm-with-and-without-%C3%AE-thalassemia-minor
#15
Xueqin Zhang, Yunshan Xiao, Yanfeng Fan
INTRODUCTION: Patients with gestational diabetes mellitus (GDM) need strict blood glucose control to reduce the incidence of perinatal complications in the mother or infant. The purpose of this study was to investigate whether the glycated hemoglobin (HbA1c) values of GDM patients were affected by β-thalassemia minor and to subsequently discuss the limitations of HbA1c monitoring for blood glucose control. METHODS: 41 GDM patients with β-thalassemia minor were enrolled to serve as the study group...
October 4, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30284688/retrospective-cohort-analysis-of-the-reduced-burden-of-hypoglycemia-associated-with-dipeptidyl-peptidase-4-inhibitor-use-in-patients-with-type-2-diabetes-mellitus
#16
Yuexin Tang, Jinan Liu, Hakima Hannachi, Samuel S Engel, Michael L Ganz, Swapnil Rajpathak
INTRODUCTION: The use of antihyperglycemic agents (AHA), especially insulin and sulfonylureas (SU), is a risk factor for hypoglycemia. Despite the significant clinical and economic burdens associated with hypoglycemia and the decreasing use of SU in favor of other oral AHA, relatively little is known about hypoglycemia trends specific to the use of non-insulin AHA. We sought to estimate annual hypoglycemia event rates and costs among patients with type 2 diabetes mellitus (T2DM) who started either SU or dipeptidyl peptidase-4 inhibitors (DPP-4i) and to predict rates and costs in the absence of DPP-4i...
October 4, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30269224/the-trend-of-high-dose-insulin-usage-among-patients-with-diabetes-in-the-uk-a-retrospective-study
#17
Iskandar Idris, Xiaomei Peng, Xuanyao He, Dongju Liu, Elemer Balogh, Puneet Kaushik, Kate Van Brunt
INTRODUCTION: Many patients with diabetes may require high-dose insulin treatment to achieve target HbA1c level, but the prevalence, disease burden, and patient characteristics of the population remain unclear. We therefore investigated people with insulin-treated diabetes in the UK from 2009 to 2013, who were prescribed high daily doses (> 200 units/day). METHODS: A retrospective analysis was conducted using the UK primary care electronic dataset from the Clinical Practice Research Datalink (CPRD)...
September 29, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30255424/association-of-pioglitazone-with-increased-risk-of-prostate-cancer-and-pancreatic-cancer-a-functional-network-study
#18
Weiheng Wen, Peili Wu, Jinru Gong, Min Zhao, Zhen Zhang, Rongping Chen, Hong Chen, Jia Sun
INTRODUCTION: The question of whether pioglitazone, an antidiabetic drug, increases the risk of cancer has been debated for some time. Recent studies have shown that pioglitazone use can increase the risk of prostate cancer as well as pancreatic cancer. However, it is unclear whether pioglitazone is a causal risk factor for these cancers. METHODS: In this study, we aimed to explore the direct targets of pioglitazone and genes associated with this drug by querying open platforms in order to construct a biological function network, and then to further evaluate the relationships of pioglitazone with prostate cancer and pancreatic cancer...
September 25, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30244319/comparison-of-efficacy-and-economic-value-of-prandilin-25-and-humalog-mix-25-in-patients-with-newly-diagnosed-type-2-diabetes-by-a-continuous-glucose-monitoring-system
#19
Yong Luo, Xue-Qin Wang, Wen-Ji Ni, Bo Ding, Xiang-Hong Xu, Lei Ye, Jian-Hua Ma, Jian Zhu
INTRODUCTION: To determine the clinical efficacy and economic value of insulin lispro 25-Prandilin 25 vs. insulin lispro 25-Humalog mix 25 in treatment of newly diagnosed type 2 diabetes mellitus (T2DM) by a continuous glucose monitoring system (CGMS). METHODS: This was a single-center, randomized, case-crossover clinical trial. Participants were randomly allocated to two groups and underwent two kinds of insulin lispro 25 treatment separated by a 1-day washout period...
September 22, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/30242612/pediatric-insulin-injection-technique-a-multi-country-survey-and-clinical-practice-implications
#20
Sanjay Kalra, Laurence J Hirsch, Anders Frid, Asma Deeb, Kenneth W Strauss
INTRODUCTION: The 2015 Insulin Injection Technique Questionnaire survey involving 13,289 patients included 898 (6.8%) patients in the pediatric age range (≤ 18 years). METHODS: The younger patients included in the questionnaire survey were grouped according to age: Group 1 (G1), 0-6 years, n = 85; Group 2(G2), 7-13, n = 423; Group 3 (G3), 14-18, n = 390. The injection technique was evaluated by means of a questionnaire and nurse assessment. RESULTS: Nurses found lipohypertrophy at injection sites in 41...
September 21, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
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