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Hormone Molecular Biology and Clinical Investigation

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https://www.readbyqxmd.com/read/29127760/preoperative-breast-mri-examination-for-all-patients-with-histologically-proven-breast-cancer-a-concept-for-a-prospective-multicenter-trial
#1
Christina Kaiser, Christina Kehrer, Mignon-Denise Keyver-Paik, Thomas Hecking, Tiyasha Hosne Ayub, Claudia Leutner, Hans Schild, Walther Kuhn
Background A published retrospective data of our study group demonstrated that premenopausal women, patients with lobular invasive breast cancer or patients with high breast density [American College of Radiology (ACR) classification 3+4] significantly benefit from magnetic resonance imaging (MRI) leading to additional detection of malignant foci of 20.2% in the index and 2.5% in the contralateral breast, which would otherwise not be detected by routine imaging. Critics of preoperative MRI focus on higher false-positive rates leading to unnecessary surgical procedures and mastectomies...
November 11, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29087956/the-impact-of-the-metabolic-syndrome-on-bone-mass-density-a-prospective-case-control-study
#2
Eleni Alhazidou, Vasilios Pergialiotis, Periklis Panagopoulos, Charalampos Chrelias, Erifili Hatziagelaki, Nikolaos Papantoniou, Eftihios Trakakis
Background Obesity and metabolic syndrome (MetS) during the perimenopausal period and in menopause have been linked to altered bone mass density (BMD) in various experimental studies. However, current clinical studies provide conflicting results in this field. The purpose of the present study was to evaluate this association. Materials and methods We conducted a prospective case control study that was based on a consecutive series of menopausal women who attended the Reproductive Endocrinology Outpatient Clinic of our hospital between January 2013 and December 2016...
October 31, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29087955/tumor-linked-her2-expression-association-with-obesity-and-lipid-related-microenvironment
#3
REVIEW
Amitabha Ray
Obesity is associated with the risk of several health disorders including certain cancers. Among obesity-related cancers, postmenopausal breast carcinoma is a well-studied one. Apart from an increase in certain types of lipids in obesity, excess adipose tissue releases many hormone-like cytokines/adipokines, which are usually pro-inflammatory in nature. Leptin is one of such adipokines and significantly linked with the intracellular signaling pathways of other growth factors such as insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), human epidermal growth factor receptor 2 (HER2)...
October 31, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28937964/breast-cancer-an-update-in-the-management
#4
EDITORIAL
René A Druckmann, Adolf E Schindler
No abstract text is available yet for this article.
September 22, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28937963/ki67-and-lymphocytes-in-the-pretherapeutic-core-biopsy-of-primary-invasive-breast-cancer-positive-markers-of-therapy-response-prediction-and-superior-survival
#5
REVIEW
Claus M Schlotter, Lothar Tietze, Ulf Vogt, Carlos Villena Heinsen, Antje Hahn
Background Core needle biopsy plays a crucial role as diagnostic tool for BC. Both Ki67 and likely tumor-infiltrating lymphocytes (TILs) in the near future are determining the kind of systemic therapy. The role of TILs in BC is still an issue for clinical research, albeit preliminary results of neoadjuvant and adjuvant clinical studies already now highlight the crucial impact of TILs on therapy response and survival. Methods Evaluation of related publications (pubmed) and meeting abstracts (ASCO, SABCS). Results The monoclonal antibody Ki67 recognizing a nuclear antigene in proliferating cells is a positive marker of therapy response and superior survival...
September 22, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28930626/pilot-study-whole-body-manual-subcutaneous-adipose-tissue-sat-therapy-improved-pain-and-sat-structure-in-women-with-lipedema
#6
Karen L Herbst, Christopher Ussery, Alyna Eekema
Background Lipedema is a common painful subcutaneous adipose tissue (SAT) disorder in women affecting the limbs. SAT therapy is a manual therapy to improve soft tissue quality. Objective Determine if SAT therapy improves pain and structure of lipedema SAT. Design Single arm prospective pilot study. Setting Academic medical center. Patients Seven women, 46 ± 5 years, weight 90 ± 19 kg, with lipedema. Intervention Twelve 90-min SAT therapy sessions over 4 weeks. Outcomes Dual X-ray absorptiometry (DXA) scans, SAT ultrasound (Vevo 2100), leg volumetrics, skin caliper assessment, tissue exam, weight, resting metabolic rate, pain assessment, lower extremity functional scale (LEFS) and body shape questionnaire (BSQ) at baseline and end of study...
September 20, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28930625/ectopic-adrenal-tissue-associated-with-borderline-mucinous-cystadenoma-of-ovary-a-case-report-with-review-of-the-literature
#7
Kah Teik Chew, Muhammad Azrai Abu, Yulianty Arifuddin, Nor Azlin Mohamed Ismail, Noor Ain Mohd Nasir, Fazarina Mohammed, Abdul Ghani Nur Azurah
Ectopic adrenal tissue in the ovary is a rare entity. We reported a case of ectopic adrenal tissue in borderline mucinous cystadenoma of the left ovary. A 22 year-old student presented with progressive abdomen distension associated with discomfort for 3 months. Imaging investigation was suggestive of mucinous left ovarian cyst. Left salpingo-oophorectomy was performed and the histopathology revealed borderline mucinous cystadenoma with an incidental finding of ectopic adrenal tissue. This is an interesting case because of its rarity and potential risk of neoplasm changes...
September 20, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28877032/bowel-endometriosis-a-diagnostic-and-therapeutic-challenge
#8
Beng Kwang Ng, Su Ee Phon, Ani Amelia Zainuddin, Wendy Yin Ling Ng, Nordashima Abd Shukor, Pei Shan Lim
Bowel endometriosis is the most common extragenital manifestation of endometriosis. Clinical suspicion is of utmost importance for achieving its diagnosis. Management of this condition is, however, always challenging to the gynaecologist. We report a case of bowel endometriosis in which the patient presented with dyschezia and haematochezia prior to her menses for the past 2 years. A 44-year-old para two woman presented with worsening dysmenorrhea and dyspareunia. She also experienced dyschezia and haematochezia prior to her menses for the past 2 years...
September 6, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28866652/the-effects-of-high-and-low-doses-of-folic-acid-on-oxidation-of-protein-levels-during-pregnancy-a-randomized-double-blind-clinical-trial
#9
Javad Shiralizadeh, Haleh Barmaki, Sanya Haiaty, Yousef Faridvand, Mostafa Mostafazadeh, Narmin Mokarizadeh, Amir Kamrani, Alireza Isazadeh, Nazila Fathi Maroufi
Objective Oxidants include important active molecules which are created in the body and attack biological molecules especially lipids, carbohydrates, nucleic acids and proteins, and cause oxidation and various diseases in the body. Antioxidants existing in the body help to avoid the incidence of these injuries. Pregnant women are among those where oxidation of biological molecules may do irreparable damage to them and their embryos. So, the purpose of this study was to review the effect of folic acid with both high (5 mg/day) and low (0...
September 4, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28866651/back-pain-in-pregnancy-among-office-workers-risk-factors-and-its-impact-on-quality-of-life
#10
Beng Kwang Ng, Mardiana Kipli, Abdul Kadir Abdul Karim, Suhaila Shohaimi, Nur Azurah Abdul Ghani, Pei Shan Lim
Background Back pain is a common presenting complaint during pregnancy and it is often being considered as part of the pregnancy process. The purpose of the study is to investigate the prevalence of back pain in pregnancy, risk factors and its impact on the quality of life in pregnant women. Materials and methods Three hundred and fifty-eight pregnant women who attended the antenatal clinic in Universiti Kebangsaan Malaysia (UKM) Medical Centre were recruited in this cross-sectional study from October 2011 until April 2012...
September 4, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28850544/breast-cancer-and-pregnancy
#11
REVIEW
Laura Knabben, Michel D Mueller
Background In the past decades the incidence of pregnancy-associated breast cancer (PABC) increased. Possible explanations are the trend to postpone childbearing and the general increase in the incidence of breast cancer. Materials and methods A sytematic review of the literature was performed with the aim to report on incidence, diagnosis, treatment and prognosis of breast cancer during pregnancy. We also cover the issue of pregnancy following a diagnosis of breast cancer including fertility preservation and prognosis...
August 29, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28949928/second-messenger-signaling-mechanisms-of-the-brown-adipocyte-thermogenic-program-an-integrative-perspective
#12
REVIEW
Fubiao Shi, Sheila Collins
β-adrenergic receptors (βARs) are well established for conveying the signal from catecholamines to adipocytes. Acting through the second messenger cyclic adenosine monophosphate (cAMP) they stimulate lipolysis and also increase the activity of brown adipocytes and the 'browning' of adipocytes within white fat depots (so-called 'brite' or 'beige' adipocytes). Brown adipose tissue mitochondria are enriched with uncoupling protein 1 (UCP1), which is a regulated proton channel that allows the dissipation of chemical energy in the form of heat...
September 26, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28942436/the-color-of-fat-and-its-central-role-in-the-development-and-progression-of-metabolic-diseases
#13
REVIEW
Melania Gaggini, Fabrizia Carli, Amalia Gastaldelli
Excess caloric intake does not always translate to an expansion of the subcutaneous adipose tissue (SAT) and increase in fat mass. It is now recognized that adipocyte type (white, WAT, or brown, BAT), size (large vs. small) and metabolism are important factors for the development of cardiometabolic diseases. When the subcutaneous adipose tissue is not able to expand in response to increased energy intake the excess substrate is stored as visceral adipose tissue or as ectopic fat in tissues as muscle, liver and pancreas...
September 25, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28888087/modulation-of-transforming-growth-factor-%C3%AE-follistatin-signaling-and-white-adipose-browning-therapeutic-implications-for-obesity-related-disorders
#14
REVIEW
Shehla Pervin, Vineeta Singh, Alexandria Tucker, Javier Collazo, Rajan Singh
Obesity is a major risk factor for the development of diabetes, insulin resistance, dyslipidemia, cardiovascular disease and other related metabolic conditions. Obesity develops from perturbations in overall cellular bioenergetics when energy intake chronically exceeds total energy expenditure. Lifestyle interventions based on reducing total energy uptake and increasing activities including exercise have proved ineffective in the prevention and treatment of obesity because of poor adherence to such interventions for an extended period of time...
September 9, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28862985/critical-review-of-beige-adipocyte-thermogenic-activation-and-contribution-to-whole-body-energy-expenditure
#15
REVIEW
Érique Castro, Tiago E Oliveira Silva, William T Festuccia
Beige (or brite, "brown in white") adipocytes are uncoupling protein 1 (UCP1)-positive cells residing in white adipose depots that, depending on the conditions, behave either as classic white adipocytes, storing energy as lipids, or as brown adipocytes, dissipating energy from oxidative metabolism as heat through non-shivering thermogenesis. Because of their thermogenic potential and, therefore, possible usage to treat metabolic diseases such as obesity and type 2 diabetes, beige cells have attracted the attention of many scientists worldwide aiming to develop strategies to safely recruit and activate their thermogenic activity...
September 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28862984/physiological-regulation-and-metabolic-role-of-browning-in-white-adipose-tissue
#16
REVIEW
Aleksandra Jankovic, Vesna Otasevic, Ana Stancic, Biljana Buzadzic, Aleksandra Korac, Bato Korac
Great progress has been made in our understanding of the browning process in white adipose tissue (WAT) in rodents. The recognition that i) adult humans have physiologically inducible brown adipose tissue (BAT) that may facilitate resistance to obesity and ii) that adult human BAT molecularly and functionally resembles beige adipose tissue in rodents, reignited optimism that obesity and obesity-related diabetes type 2 can be battled by controlling the browning of WAT. In this review the main cellular mechanisms and molecular mediators of browning of WAT in different physiological states are summarized...
September 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28862983/the-association-of-nov-ccn3-with-obstructive-sleep-apnea-osa-preliminary-evidence-of-a-novel-biomarker-in-osa
#17
Jeremy A Weingarten, Lars Bellner, Stephen J Peterson, Moe Zaw, Puja Chadha, Shailendra P Singh, Nader G Abraham
Obstructive sleep apnea (OSA) has a strong association with cardiovascular and metabolic abnormalities, although the mechanism driving this association is not well established. NOV/CCN3, a multifunctional extracellular matrix protein, may play a mechanistic and/or prognostic role in these associations. We hypothesized that patients with OSA, which primarily affects obese individuals, will have increased levels of NOV, and that NOV can serve as a biomarker in patients to predict OSA as well as metabolic and cardiac risk...
September 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28850545/endocrine-and-autocrine-paracrine-modulators-of-brown-adipose-tissue-mass-and-activity-as-novel-therapeutic-strategies-against-obesity-and-type-2-diabetes
#18
REVIEW
Marcel Scheideler, Stephan Herzig, Anastasia Georgiadi
The dramatically increasing world-wide prevalence of obesity is recognized as a risk factor for the development of various diseases. The growing research on the role of adipose tissue in controlling energy homeostasis and insulin sensitivity has revealed that the promotion of brown adipose tissue (BAT) activity and the browning of white adipose tissue (WAT) leads to multiple health benefits and prevents obesity and type 2 diabetes (T2D). Inducible thermogenic adipocytes do exist in adult humans and are linked with increased energy combustion and lower body fat mass...
August 29, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28796641/the-effect-of-thyroid-dysfunction-on-nesfatin-1-and-adiponectin-levels-in-rats
#19
Emine Atıci, Rasim Mogulkoc, Abdulkerim Kasım Baltaci, Esma Menevse
Background Changes in thyroid hormone concentrations may affect adiponectin concentrations through various mechanisms. A molecule released primarily from the fat cells adiposities; adiponectin has important effects on the regulation of body weight. Aim The present study aimed to explore the effects of experimental thyroid dysfunction and its treatment on nesfatin-1 and adiponectin levels in rats. Methods The study included 40 adult male Sprague-Dawley rats which were grouped as follows: (1) control; (2) hypothyroidism [hypothyroidism was induced by intraperitoneal injection of 10 mg/kg/day propylthiouracil (PTU) for 3 weeks]; (3) hypothyroidism + thyroxine group [after hypothyroidism was induced by 2-week PTU injection, they were treated with high-dose L-thyroxine (1...
August 10, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28779564/the-functional-significance-of-14-3-3-proteins-in-cancer-focus-on-lung-cancer
#20
REVIEW
Afshin Khorrami, Mahyar Sharif Bagheri, Mahmood Tavallaei, Javad Gharechahi
The 14-3-3 family proteins are phosphoserine/phosphothreonine binding proteins constituting a conserved class of proteins which are detected in all eukaryotic cells. In mammalians, 14-3-3 proteins have seven distinct isoforms (β, γ, ε, η, ζ, σ and τ/θ) which are involved in various cellular processes including signal transduction, cell cycle, cell proliferation, apoptosis, differentiation and survival. 14-3-3 proteins do not have a distinct catalytic activity and often regulate the activity, stability, subcellular localization and interactions of other proteins...
August 5, 2017: Hormone Molecular Biology and Clinical Investigation
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