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Hormone Molecular Biology and Clinical Investigation

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https://www.readbyqxmd.com/read/30517076/ovarian-reserve-in-adolescent-girls-born-prematurely
#1
Svetlana Elgina, Natalia Artymuk, Elena Nikulina
Background The objective was to estimate ovarian reserve in adolescent girls born prematurely. Materials and methods Two hundred adolescent girls aged 15-16 years who were born prematurely and full term were studied with laboratory, ultrasound and statistical methods. Results Statistically significant differences of the main parameters that characterize ovarian reserve in adolescent girls born prematurely compared to those born full term were specified. The levels of estradiol (p = 0.027), anti-Müllerian hormone (p = 0...
December 5, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30496135/proportional-correlates-of-cystatin-c-with-pentraxin-3-visceral-adiposity-index-and-atherogenicity-index-of-plasma-but-not-blood-indices-in-metabolic-syndrome-patients-with-and-without-prediabetes
#2
Musa Moh'd Waleed Al-Batsh, Abla Albsoul-Younes, Violet Kasabri, Maysa Suyagh, Sundos Alalawi, Nada Yasin
Background Pentraxin-3 (PXT-3) and cystatin-C (Cys-C) are robustly related with central obesity and insulin resistance in prediabetes/metabolic syndrome (preDM-MetS). Materials and methods This cross-sectional study aimed to compare and correlate PXT-3 and Cys-C plasma levels in 29 normoglycemic MetS patients, 30 newly diagnosed drug naive preDM-MetS cases vs. 29 normoglycemic lean controls. Results Unlike PXT-3; Cys-C level was significantly higher in normoglycemic MetS (but not preDM-MetS) vs. healthy controls...
November 29, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30471220/impact-of-adipose-tissue-on-prostate-cancer-aggressiveness-analysis-of-a-high-risk-population
#3
Guila Delouya, David Tiberi, Sahir R Bhatnagar, Shanie Campeau, Fred Saad, Daniel Taussky
Background We investigated whether visceral adiposity is associated with more aggressive disease at prostatectomy. Materials and methods Four hundred and seventy-four patients referred for postoperative adjuvant or salvage radiotherapy were included in this study. Primary endpoints were positive surgical margins (pSM) or extracapsular extension (ECE). Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were manually contoured. Univariate and multivariate logistic regression was performed. Results In univariate analysis, VAT volume (p = 0...
November 24, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30462610/the-impact-of-steatosis-on-liver-regeneration
#4
REVIEW
Manon Allaire, Hélène Gilgenkrantz
Alcoholic and non-alcoholic fatty liver diseases are the leading causes of cirrhosis in Western countries. These chronic liver diseases share common pathological features ranging from steatosis to steatohepatitis. Fatty liver is associated with primary liver graft dysfunction, a higher incidence of complications/mortality after surgery, in correlation with impaired liver regeneration. Liver regeneration is a multistep process including a priming phase under the control of cytokines followed by a growth factor receptor activation phase leading to hepatocyte proliferation...
November 21, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30447140/impact-of-progestogens-on-hemostasis
#5
REVIEW
Sven O Skouby, Johannes J Sidelmann
Combined hormonal contraception containing estrogen and progestogen and postmenopausal hormone therapy with estrogen ± progestogen are reported risk factors for venous thrombosis. The thrombotic risk varies by estrogen dose and type of progestogen. Estrogen combined with "newer generation" progestogens in combined oral contraceptives may have higher thrombotic risk than estrogen combined with older generation progestogens. Among postmenopausal women thrombotic risk also varies by type of hormone and mode of delivery...
November 17, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30427780/direct-and-indirect-effects-of-psychopharmacological-treatment-on-the-cardiovascular-system
#6
Kai G Kahl
Background Severe mental disorders, i.e. psychotic disorders, unipolar and bipolar disorders are associated with increased morbidity and mortality from cardiovascular and metabolic disorders. The underlying cause of this association is complex and comprises disorder specific alterations such as dysfunctions of immunological and hormonal systems, body-composition changes and health associated behaviors (smoking, sedentary lifestyle, alcohol intake and treatment compliance). Furthermore, some psychopharmacological drugs may exert unwanted side effects that impact the cardiovascular system...
November 14, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30427779/effects-of-different-exercise-loads-on-the-thyroid-hormone-levels-and-serum-lipid-profile-in-swimmers
#7
Sayad Kocahan, Aykut Dundar
Background The aim of this study was to investigate the effects of different exercise loads (short, medium and long swimming distances) on the thyroid hormone (THs) levels and serum lipid profiles of male professional swimmers. Materials and methods The participants in this study were 20 healthy male professional swimmers aged 18-22 years, who all competed at an elite level. The THs levels [thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4)] and serum lipid profile were also obtained...
November 14, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30398970/the-effects-of-estradiol-and-testosterone-on-renal-tissues-oxidative-after-central-injection-of-angiotensin-ii-in-female-doca-salt-treated-rats
#8
Marzieh Kafami, Mahmoud Hosseini, Saeed Niazmand, Esmaeil Farrokhi, Mosa Al-Reza Hajzadeh, Samad Nazemi
Background Although numerous studies have proven that estrogen (Est) has a protective effect on the development of hypertension, more research needs to be done to show its detailed mechanism in a variety of hypertension. The important role of active oxygen species in blood pressure is well defined. We examined whether or not sex hormones change the growth of reactive oxygen species (ROS) ‎in kidneys after central microinjection of angiotensin II (Ang II).‎ Materials and methods Female Wistar rats, 8 weeks old (200 ± 10 g) were used in this study...
November 6, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30367794/copper-and-zinc-in-stage-i-multiple-myeloma-relation-with-ceruloplasmin-lipid-peroxidation-and-superoxide-dismutase-activity
#9
Mohammad-Hassan Khadem-Ansari, Mojtaba Asoudeh, Hosein Fallahi Kord Gheshlaghi, Samira Nozari, Mina Zarringol, Nazila Fathi Maroufi, Yousef Faridvand
Background The main aim of this study was to assess the serum levels of copper (Cu), zinc (Zn) with lipid peroxidation, Cu/Zn superoxide dismutase (Cu/Zn SOD) activity, and ceruloplasmin (Cp) in multiple myeloma (MM) patients. Materials and methods The study was conducted in 34 MM patients at stage I. Serum Cu and Zn levels were measured by atomic absorption spectrometry. Also, spectrophotometric assays of malondialdehyde (MDA) levels in addition to Cp and Cu/Zn SOD were quantitated. Results The results showed a significant decrease in the serum Zn levels in patients with MM (p < 0...
October 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30367793/exercise-training-increases-cardiac-hepatic-and-circulating-levels-of-brain-derived-neurotrophic-factor-and-irisin-in-young-and-aged-rats
#10
Muaz Belviranlı, Nilsel Okudan
Background The objective of study was to examine the impacts of exercise training on cardiac, hepatic and plasma brain-derived neurotrophic factor (BDNF) and irisin levels in young and aged rats. Materials and methods Four-month-old (young) and 20-month-old (aged) female rats performed exercise training consisting of voluntary wheel running for 12 weeks. BDNF and irisin levels were analyzed in the heart, liver and plasma samples by using commercially available enzyme-linked immunosorbent assay (ELISA) kits...
October 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30367792/hypothyroidism-and-nonalcoholic-fatty-liver-disease-a-chance-association
#11
REVIEW
Simonetta Lugari, Alessandro Mantovani, Fabio Nascimbeni, Amedeo Lonardo
Background Nonalcoholic fatty liver disease (NAFLD) defines the clinical-pathological spectrum of hepatic lipotoxicity, which may progress to hepatic fibrosis and its complications. Thyroid hormone is a master regulator of cell metabolism and body fat distribution. Whether hypothyroidism is associated or not with an increased risk of developing NAFLD and its fibrotic progression is both clinically and physiopathologically relevant. Indeed, answering this research question would carry major pathogenic and therapeutic implications...
October 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30367791/clinical-relevance-in-present-day-hormonal-contraception
#12
REVIEW
Pedro-Antonio Regidor
The contraceptive pill is an effective and very safe method to control pregnancies. It was developed 60 years ago, and despite that the composition has been the same since it was first developed (estrogen and progestogen), over the years the concentration of ethinyl estradiol has been reduced to improve tolerability. Nevertheless, progestogens are the basic active agent of hormonal contraception. The mechanism of progestogens is a multimodal one and basically three modes of contraceptive action can be distinguished: (a) A strong antigonadotrophic action leading to the inhibition of ovulation...
October 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30256758/the-response-of-meteorin-like-hormone-and-interleukin-4-in-overweight-women-during-exercise-in-temperate-warm-and-cold-water
#13
Marziyeh Saghebjoo, Afsaneh Einaloo, Mehdi Mogharnasi, Fereshteh Ahmadabadi
Background Meteorin-like hormone (Metrnl) and interleukin-4 (IL-4) are protein molecules that stimulate the production of brown adipose tissue to improve diseases such as type 2 diabetes and obesity. The aim of this study was to investigate the response of Metrnl protein and IL-4 in overweight women during exercise in temperate, warm and cold water. Materials and methods Thirteen overweight young women (mean age 25.21 ± 3.27 years, body mass index 26.43 ± 1.34 kg/m2) were selected randomly and performed three sessions of interval exercise (40 min per session, 65% of maximum oxygen consumption) in non-consecutive days in temperate (24-25 °C), warm (36...
September 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30256757/effect-of-experimentally-induced-hypothyroidism-during-gestation-period-on-activity-dependent-neurotrophic-factor-adnf-in-newborn-rat-brain-tissue
#14
Gökhan Cesur, Mehtap Kılıç Eren, Erdal Eren, Kemal Ergin, Rauf Onur Ek, Yüksel Yıldız, Ferhat Şirinyıldız, Umut Gök Balcı, Kurtulus Ongel
Purpose The aim of the study was to evaluate the effects of prenatal hypothyroidism on neonatal rats by the way of activity-dependent neuroprotective factor (ADNF) expression. Methods Twenty-one Wistar albino neonatal rats were divided into two subgroups; a control group and neonatal rats with experimental maternal hypothyroidism. Hypothyroidism was induced by using propylthiouracil (PTU). Neonatal rats obtained PTU from breast milk continuously for 1 week after birth. The rats from the control group were fed only normal feed and water...
September 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30218603/the-influence-of-thyroid-disorders-on-bone-density-and-biochemical-markers-of-bone-metabolism
#15
Konstantinos Tsevis, Eftihios Trakakis, Vasilios Pergialiotis, Eleni Alhazidou, Melpomeni Peppa, Charalampos Chrelias, Nikolaos Papantoniou, Periklis Panagopoulos
Background Thyroid dysfunction, predominantly hyperthyroidism, has been previously linked to impaired bone mass density (BMD) and increased risk of fractures. On the other hand, data in the field of hypothyroidism (HT) are missing. The purpose of the present study was to investigate the impact of thyroid disorders on bone density serum and urine calcium (Ca) and phosphate (P) as well as serum osteocalcin and alkaline phosphatase and urine hydroxyproline in a series of post-menopausal women. Materials and methods The study was conducted in the Reproductive Endocrinology Outpatient Clinic of our hospital...
September 15, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30205658/comparison-of-performing-12-weeks-resistance-training-before-after-and-or-in-between-aerobic-exercise-on-the-hormonal-status-of-aged-women-a-randomized-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Ebrahim Banitalebi, Mohammad Faramarzi, Laleh Bagheri, Abdol Reza Kazemi
Background Physiological aging can now be considered as a multi-factorial process that is associated with anatomical and signaling changes associated with endocrine function. The purpose of this study was to investigate the comparison of performing 12 weeks' resistance training before, after and/or in between aerobic exercise on the hormonal status of aged women. Materials and methods Forty healthy aged women (age: 67.35 ± 1.40 years) were randomly divided into three training groups and a control group: resistance followed by endurance training (ER, n = 12), endurance training followed by resistance training (RE, n = 12, interval resistance-endurance (RE) training (INT, n = 12) and a control (Con, n = 12) groups...
September 8, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30205641/cross-sectional-correlates-of-nesfatin-and-lipopolysaccharide-binding-protein-in-metabolic-syndrome-patients-with-and-without-prediabetes
#17
Safa'a Ali Al-Qudah, Violet Kasabri, Mohammad Issa Saleh, Maysa Suyagh, Sundos AlAlawi, Nada Yasin
No abstract text is available yet for this article.
September 6, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30171810/metalloproteinases-in-non-alcoholic-fatty-liver-disease-and-their-behavior-in-liver-fibrosis
#18
REVIEW
Magalí Barchuk, Laura Schreier, Gabriela Berg, Verónica Miksztowicz
No abstract text is available yet for this article.
September 1, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30144385/kjell-carlstr%C3%A3-m-1940-2018
#19
Gunnar Söderqvist, Eva Lundström
No abstract text is available yet for this article.
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30144384/congenital-complete-heart-block-in-pregnancy
#20
Nurul Iftida Basri, Shuhaila Ahmad
Complete heart block (CHB) is infrequently encountered during pregnancy. Its management requires a multidisciplinary approach involving the obstetrician, cardiologist, anesthetist and neonatologist. It varies from conservative, temporary or permanent pacemaker (PPM) insertion (either during the antenatal, intrapartum or postpartum period). We present the case of a 30-year-old, gravida 2 para 1 at the 36-week period of amenorrhea (POA) with congenital CHB. She was asymptomatic throughout her pregnancy despite having a pulse rate between 40 and 50 beats per minute...
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
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