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Hormone Molecular Biology and Clinical Investigation

Safa'a Ali Al-Qudah, Violet Kasabri, Mohammad Issa Saleh, Maysa Suyagh, Sundos AlAlawi, Nada Yasin
No abstract text is available yet for this article.
September 6, 2018: Hormone Molecular Biology and Clinical Investigation
Magalí Barchuk, Laura Schreier, Gabriela Berg, Verónica Miksztowicz
No abstract text is available yet for this article.
September 1, 2018: Hormone Molecular Biology and Clinical Investigation
Xiangyan Ruan, Alfred O Mueck
No abstract text is available yet for this article.
August 18, 2018: Hormone Molecular Biology and Clinical Investigation
Charlotte J Green, Siôn A Parry, Pippa J Gunn, Carlo D L Ceresa, Fredrik Rosqvist, Marie-Eve Piché, Leanne Hodson
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. Determining the pathogenesis and pathophysiology of human NAFLD will allow for evidence-based prevention strategies, and more targeted mechanistic investigations. Various in vivo, ex situ and in vitro models may be utilised to study NAFLD; but all come with their own specific caveats. Here, we review the human-based models and discuss their advantages and limitations in regards to studying the development and progression of NAFLD. Overall, in vivo whole-body human studies are advantageous in that they allow for investigation within the physiological setting, however, limited accessibility to the liver makes direct investigations challenging...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
Alfred O Mueck, Thomas Römer
Transdermal estradiol (TE) application (using gels, patches or a novel spray) is now a preferred route of hormone therapy (HT) in menopausal women, because various risks such as venous thromboembolism, stroke and unwanted hepatic effects can be reduced compared with oral HT. However, in the presence of an intact uterus, concurrent administration of progestogen is needed for endometrial protection. Due to the variety of progestogens available and differences in their clinical effects, the selection of the most appropriate substance and dosing for individual combination therapy can be difficult...
July 31, 2018: Hormone Molecular Biology and Clinical Investigation
Mehmet Akif Camkurt, Luca Lavagnino, Xiang Y Zhang, Antonio L Teixeira
Obesity and diabetes are both risk factors and consequences of psychiatric disorders. Glucagon like peptide 1 (GLP-1) receptor agonists such as liraglutide are widely used in the treatment of diabetes and obesity. There are considerable amounts of preclinical studies showing the effects of liraglutide on promotion of neurogenesis, while preventing apoptosis and oxidation. Preliminary clinical evidence has suggested that liraglutide could decrease weight gain, improve cognition and prevent cognitive decline...
July 18, 2018: Hormone Molecular Biology and Clinical Investigation
Armando Piccinni, Donatella Marazziti, Claudio Cargioli, Mauro Mauri, Tiziana Stallone
Background Food addiction (FA) is a controversial concept, denoting the craving for certain foods. Given the little information available, the aim of this study was to evaluate the possible relationships between FA and full-blown and subthreshold psychopathology or eating behaviors in subjects consulting nutritional biologists. Materials and methods Three-hundred and fifty subjects completed the following self-questionnaires: Yale Food Addiction Scale (YFAS), Structured Clinical Interview for Mood Spectrum, Self-Report, Lifetime Version (MOOD-SR-LT), Symptom Checklist-90-Revised (SCL-90-R), Structured Clinical Interview for Anorexic-Bulimic Spectrum, Self-Report, Lifetime Version (ABS-SR-LT)...
June 28, 2018: Hormone Molecular Biology and Clinical Investigation
Konstantinos Tsevis, Eftihios Trakakis, Vasilios Pergialiotis, Eleni Alhazidou, Melpomeni Peppa, Charalampos Chrelias, Nikolaos Papantoniou, Periklis Panagopoulos
Background Thyroid dysfunction, predominantly hyperthyroidism, has been previously linked to impaired bone mass density (BMD) and increased risk of fractures. On the other hand, data in the field of hypothyroidism (HT) are missing. The purpose of the present study was to investigate the impact of thyroid disorders on bone density serum and urine calcium (Ca) and phosphate (P) as well as serum osteocalcin and alkaline phosphatase and urine hydroxyproline in a series of post-menopausal women. Materials and methods The study was conducted in the Reproductive Endocrinology Outpatient Clinic of our hospital...
September 15, 2018: Hormone Molecular Biology and Clinical Investigation
Ebrahim Banitalebi, Mohammad Faramarzi, Laleh Bagheri, Abdol Reza Kazemi
Background Physiological aging can now be considered as a multi-factorial process that is associated with anatomical and signaling changes associated with endocrine function. The purpose of this study was to investigate the comparison of performing 12 weeks' resistance training before, after and/or in between aerobic exercise on the hormonal status of aged women. Materials and methods Forty healthy aged women (age: 67.35 ± 1.40 years) were randomly divided into three training groups and a control group: resistance followed by endurance training (ER, n = 12), endurance training followed by resistance training (RE, n = 12, interval resistance-endurance (RE) training (INT, n = 12) and a control (Con, n = 12) groups...
September 8, 2018: Hormone Molecular Biology and Clinical Investigation
Gunnar Söderqvist, Eva Lundström
No abstract text is available yet for this article.
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
Nurul Iftida Basri, Shuhaila Ahmad
Complete heart block (CHB) is infrequently encountered during pregnancy. Its management requires a multidisciplinary approach involving the obstetrician, cardiologist, anesthetist and neonatologist. It varies from conservative, temporary or permanent pacemaker (PPM) insertion (either during the antenatal, intrapartum or postpartum period). We present the case of a 30-year-old, gravida 2 para 1 at the 36-week period of amenorrhea (POA) with congenital CHB. She was asymptomatic throughout her pregnancy despite having a pulse rate between 40 and 50 beats per minute...
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
Charalampos Siristatidis, Ioannis Rigos, Vasilios Pergialiotis, Vasilios Karageorgiou, Nikolaos Christoforidis, George Daskalakis, Stefano Bettocchi, Antonis Makrigiannakis
We propose a study protocol capable of improving clinical outcomes following medically assisted reproduction (MAR) in infertile women with endometriosis and polycystic ovary syndrome (PCOS). The proposed research derives from the published evidence on the positive impact from endometrial injury (EI) and the beneficial nature of the intervention towards improved implantation rates. We primarily refer to the cluster of events and hypotheses, such as the mechanical cascade, the inflammatory response per se, the events accompanying wound healing, the immune cell recruitment and protein involvement, alterations in gene expression and the neo-angiogenesis theories, which have been previously investigated for this purpose...
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
Eva Lundström, Kjell Carlström, Sabine Naessen, Gunnar Söderqvist
Background Androgens, notably testosterone inhibit breast cell proliferation and negative correlations between free testosterone (fT) and breast cell proliferation as well as mammographic density have been described. Dehydroepiandrosterone (DHEA) is reported to be a partial androgen antagonist in breast tumor cells in vitro. Our aim was to investigate if circulating DHEA had any effects on the association between circulating fT and mammographic density in vivo in the normal postmenopausal breast. Methods We measured visual and digitized mammographic density and serum DHEA, testosterone, sex-hormone-binding globulin and calculated fT in 84 healthy untreated postmenopausal women...
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
Soon Leong Yong, Safilah Dahian, Aznim Hani Ramlan, Marcus Kang
Normal-sized ovarian carcinoma syndrome (NOCS) is a rare condition characterised by malignancy identified in ovaries of normal size with abdominal metastasis. We report two cases of advanced ovarian carcinoma with ovaries of normal size. The first case was a 13-year-old adolescent with malignant ascites and bilateral normal sized multicystic ovaries detected on ultrasound. Serum cancer antigen 125 (CA 125) and lactate dehydrogenase were markedly raised. A computed tomography (CT) scan showed the presence of thick omental cake but no ovarian tumour...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
Nima Taefehshokr, Alireza Isazadeh, Amin Oveisi, Yashar Azari Key, Sina Taefehshokr
Background Human β-defensins (hBD2 and hBD3) are small cationic antimicrobial peptides of innate immune system which can act as a barrier against the majority of pathogens, contributing to the host immune defence. Objective The aim of study is to determine whether hBD2 and hBD3 play a role in development and proliferation of human effector CD4 T cells or not. Furthermore, if enhanced proliferation is observed in the presence of hBD2 and hBD3, these data will demonstrate whether chemokine receptor type 6 (CCR6) is required to be present for this activity to occur...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
Beng Hock Teh, Soon Leong Yong, Wee Wee Sim, Kim Bee Lau, Haris Njoo Suharjono
Background This study was conducted to evaluate the performance of human epididymal protein 4 (HE4), cancer antigen 125 (CA 125) and a combination of both via the Risk of Ovarian Malignancy Algorithm (ROMA) in detecting ovarian malignancy. Methods This was a diagnostic study enrolling 129 patients with pelvic mass(es) suspected of originating in the ovary who had been scheduled for surgery or radiological-guided biopsy. Serum HE4 and CA 125 levels were measured. HE4, CA 125 and ROMA were evaluated for sensitivity, specificity, positive predictive value and negative predictive value...
July 31, 2018: Hormone Molecular Biology and Clinical Investigation
Benjamin Lebrun, Yves Jacquemyn
Background Fetal red blood cells (FRBC) in maternal blood are counted in rhesus-negative women to determine the amount of anti-D immunoglobulin to be administered in the case of a rhesus-positive fetus. In rhesus-positive pregnant women this is done in not always very well-defined indications including trauma, miscarriage, fetal death and diminished fetal movements. The aim of this study is to determine if the detection of FRBC is useful in rhesus-positive pregnant woman. This was done by assessing maternal and fetal characteristics that are more likely to give a positive test...
July 31, 2018: Hormone Molecular Biology and Clinical Investigation
Mohsen Khosravi, Reza Hosseini-Fard, Mohammad Najafi
Low-density lipoprotein (LDL) particles are known as atherogenic agents in coronary artery diseases. They modify to other electronegative forms and may be the subject for improvement of inflammatory events in vessel subendothelial spaces. The circulating LDL value is associated with the plasma PCSK-9 level. They internalize into macrophages using the lysosomal receptor-mediated pathways. LDL uptake is related to the membrane scavenger receptors, modifications of lipid and protein components of LDL particles, vesicular maturation and lipid stores of cells...
July 31, 2018: Hormone Molecular Biology and Clinical Investigation
Dede Sit, Ender Tanrıverdi, Hasan Kayabasi, Muslum Erdem, Hakan Sari
Purpose Metabolic syndrome (MetS) is a polymetabolic syndrome has high morbidity and mortality rates. Insulin resistance (IR) plays a key role in the increasing frequency of this situation and has been cited as being an important etiologic factor in MetS. In this study, the relationship between IR and fibroblast growth factor-23 (FGF23), was investigated in a population with MetS. Materials and methods Forty patients with diagnosis of MetS and 40 healthy volunteers with an equal number of males and females were included in the study and classified as patient group and control group...
July 12, 2018: Hormone Molecular Biology and Clinical Investigation
Ibrahim Abdul Kareem Al-Sarraf, Violet Kasabri, Amal Akour, Randa Naffa
Background Metabolic syndrome (MetS) is a cluster of metabolic risk factors which increases the chances for future cardiovascular diseases, as well as diabetes. The underlying causes of MetS include overweight and obesity, physical inactivity and genetic factors. Our intension here was to focus in this study on the importance of the chronobiology, represented by melatonin (MT) and cryptochrome 2 (CRY2), in developing MetS and type 2 diabetes mellitus (T2DM). Thus, we aimed to compare MT and CRY2 plasma levels and correlate both biomarkers with adiposity, atherogenicity and hematological indices in MetS and T2DM cohorts...
May 29, 2018: Hormone Molecular Biology and Clinical Investigation
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