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Hormone Molecular Biology and Clinical Investigation

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https://www.readbyqxmd.com/read/30001211/is-fgf23-effective-on-insulin-resistance-in-individuals-with-metabolic-syndrome
#1
Dede Sit, Ender Tanrıverdi, Hasan Kayabasi, Muslum Erdem, Hakan Sari
Purpose Metabolic syndrome (MetS) is a polymetabolic syndrome has high morbidity and mortality rates. Insulin resistance (IR) plays a key role in the increasing frequency of this situation and has been cited as being an important etiologic factor in MetS. In this study, the relationship between IR and fibroblast growth factor-23 (FGF23), was investigated in a population with MetS. Materials and methods Forty patients with diagnosis of MetS and 40 healthy volunteers with an equal number of males and females were included in the study and classified as patient group and control group...
July 12, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29953402/food-addiction-is-it-a-nosological-category-or-a-psychopathological-dimension-preliminary-results-of-an-italian-study
#2
Armando Piccinni, Donatella Marazziti, Claudio Cargioli, Mauro Mauri, Tiziana Stallone
Background Food addiction (FA) is a controversial concept, denoting the craving for certain foods. Given the little information available, the aim of this study was to evaluate the possible relationships between FA and full-blown and subthreshold psychopathology or eating behaviors in subjects consulting nutritional biologists. Materials and methods Three-hundred and fifty subjects completed the following self-questionnaires: Yale Food Addiction Scale (YFAS), Structured Clinical Interview for Mood Spectrum, Self-Report, Lifetime Version (MOOD-SR-LT), Symptom Checklist-90-Revised (SCL-90-R), Structured Clinical Interview for Anorexic-Bulimic Spectrum, Self-Report, Lifetime Version (ABS-SR-LT)...
June 28, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29813030/melatonin-and-cryptochrome-2-in-metabolic-syndrome-patients-with-or-without-diabetes-a-cross-sectional-study
#3
Ibrahim Abdul Kareem Al-Sarraf, Violet Kasabri, Amal Akour, Randa Naffa
Background Metabolic syndrome (MetS) is a cluster of metabolic risk factors which increases the chances for future cardiovascular diseases, as well as diabetes. The underlying causes of MetS include overweight and obesity, physical inactivity and genetic factors. Our intension here was to focus in this study on the importance of the chronobiology, represented by melatonin (MT) and cryptochrome 2 (CRY2), in developing MetS and type 2 diabetes mellitus (T2DM). Thus, we aimed to compare MT and CRY2 plasma levels and correlate both biomarkers with adiposity, atherogenicity and hematological indices in MetS and T2DM cohorts...
May 29, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29768247/oocyte-triggering-day-progesterone-levels-and-endometrial-appearance-in-normoresponders-undergoing-ivf-icsi-cycles-a-hypothesis-and-a-study-protocol
#4
Charalampos Siristatidis, Panagiotis Drakopoulos, Paraskevi Vogiatzi, Vasilios Karageorgiou, George Daskalakis
In this report, we propose a study protocol capable of improving IVF outcomes in subfertile women with expected normal ovarian response. This proposal derives from conflicting published data and observations in our daily practice, concerning the negative impact of progesterone (P4) elevation at the day of oocyte triggering on pregnancy outcomes. Our hypothesis points to the combination of two previous "suspects" of reduced success after assisted reproduction techniques (ART) - the endometrium ultrasonographic parameters and P4 elevation at the day of oocyte triggering on their impact on pregnancy outcomes...
May 16, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29694329/correlation-of-platelet-to-lymphocyte-and-neutrophil-to-lymphocyte-ratio-with-hormonal-and-metabolic-parameters-in-women-with-pcos
#5
Vasilios Pergialiotis, Eftihios Trakakis, Christos Parthenis, Erifili Hatziagelaki, Charalampos Chrelias, Nikolaos Thomakos, Nikolaos Papantoniou
Background The purpose of our study is to evaluate the association of platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) with hormonal and metabolic parameters in patients with polycystic ovarian syndrome (PCOS) in order to assess whether these ratios may become useful tools during the evaluation of the severity of low grade inflammation. Methods The present study is based in secondary outcomes from a prospectively collected patient database. A total of 266 women with PCOS participated in this study and blood a complete blood count examination (CBC) that was used for the calculation of PLR and NLR was available in 182 patients...
April 25, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29750646/circulating-steroid-levels-as-correlates-of-adipose-tissue-phenotype-in-premenopausal-women
#6
Geneviève B Marchand, Anne-Marie Carreau, Sofia Laforest, Julie-Anne Côté, Marleen Daris, Katherine Cianflone, Cornelia Prehn, Jerzy Adamski, André Tchernof
Background Obesity-related alterations in the circulating steroid hormone profile remain equivocal in women. Our objective was to identify circulating steroid levels that relate to increased adiposity and altered adipose phenotype in premenopausal women. Materials and methods In a sample of 42 premenopausal women [age 46 ± 3 years; body mass index (BMI) 27.1 ± 4.2 kg/m2], 19 plasma steroids were quantified by electrospray ionization-liquid chromatography-tandem mass spectroscopy (ESI-LC-MS/MS). Body composition and fat distribution were assessed by dual-energy X-ray absorptiometry (DXA) and computed tomography (CT), respectively...
May 11, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29668463/changes-to-trimethylamine-n-oxide-and-its-precursors-in-nascent-metabolic-syndrome
#7
Daniella Lent-Schochet, Ryan Silva, Matthew McLaughlin, Beverley Huet, Ishwarlal Jialal
Background Metabolic syndrome (MetS), a cardio-metabolic cluster afflicting 35% of American adults, increases cardiovascular disease (CVD) and type-2 diabetes (T2DM) risk. Increased levels of trimethylamine N-oxide (TMAO), a metabolite derived from choline and L-carnitine, correlates with CVD and T2DM. However, the precise role of TMAO and its precursors in MetS remains unclear. We tested the hypothesis that choline, L-carnitine and TMAO in MetS patients without CVD or T2DM would be altered and correlate with inflammatory markers...
April 18, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29630513/basic-pituitary-ovarian-hormones-and-ultrasound-parameters-of-uterine-appendages-in-full-term-and-preterm-neonate-girls
#8
Natalia Artymuk, Svetlana I Yelgina, Elena Nikulina
Objective To determine the basic pituitary-ovarian hormones and ultrasound parameters of uterine appendages in full-term and preterm newborn girls. Materials and methods One hundred full-term and premature newborn girls (58 and 42, respectively) were studied with clinical, instrumental, laboratory (enzyme immunoassay) and statistical methods. Results Statistically significant differences in the pituitary-ovarian hormones and ultrasound parameters of uterine appendages in preterm neonate girls compared to full-term girls were defined...
April 10, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29601300/cannabinoids-in-health-and-disease-pharmacological-potential-in-metabolic-syndrome-and-neuroinflammation
#9
REVIEW
Andrea Mastinu, Marika Premoli, Giulia Ferrari-Toninelli, Simone Tambaro, Giuseppina Maccarinelli, Maurizio Memo, Sara Anna Bonini
The use of different natural and/or synthetic preparations of Cannabis sativa is associated with therapeutic strategies for many diseases. Indeed, thanks to the widespread diffusion of the cannabinoidergic system in the brain and in the peripheral districts, its stimulation, or inhibition, regulates many pathophysiological phenomena. In particular, central activation of the cannabinoidergic system modulates the limbic and mesolimbic response which leads to food craving. Moreover, cannabinoid agonists are able to reduce inflammatory response...
March 30, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29596053/the-adipose-tissue-expandability-hypothesis-a-potential-mechanism-for-insulin-resistance-in-obese-youth
#10
REVIEW
Sonia Caprio, Bridget Pierpont, Romy Kursawe
Obesity has become a major global health challenge of the 21st century, as it is associated with the onset of type 2 diabetes (T2D) and cardiovascular complications, even at a very early age in life. The root causes of pediatric obesity remain incompletely understood. The obesity epidemic together with the relationship of obesity to the growing population burden of chronic disease presents unprecedented research opportunities and challenges. Decades of obesity-related research funded by governments around the world have yielded many important discoveries about both etiological pathways and preventive or therapeutic interventions...
March 29, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29596052/the-impact-of-mild-hypercholesterolemia-on-glycemic-and-hormonal-profiles-menstrual-characteristics-and-the-ovarian-morphology-of-women-with-polycystic-ovarian-syndrome
#11
Vasilios Pergialiotis, Eftihios Trakakis, Charalampos Chrelias, Nikolaos Papantoniou, Erifili Hatziagelaki
Background The severity of polycystic ovarian syndrome (PCOS) has been clearly associated with insulin resistance, obesity and metabolic syndrome. The purpose of the present cross-sectional study is to investigate whether mild hypercholesterolemia alters the biochemical and clinical profile of PCOS patients. Methods Our study is based on a prospectively collected population of women of reproductive age who were diagnosed with PCOS according to the definition of the Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ASRM/ESHRE) criteria...
March 29, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29804101/metabolic-and-neuroendocrine-adaptations-to-undernutrition-in-anorexia-nervosa-from-a-clinical-to-a-basic-research-point-of-view
#12
REVIEW
Odile Viltart, Philibert Duriez, Virginie Tolle
The exact mechanisms linking metabolic and neuroendocrine adaptations to undernutrition and the pathophysiology of anorexia nervosa (AN) are not fully understood. AN is a psychiatric disorder of complex etiology characterized by extreme starvation while the disease is progressing into a chronic state. Metabolic and endocrine alterations associated to this disorder are part of a powerful response to maintain whole body energy homeostasis. But these modifications may also contribute to associated neuropsychiatric symptoms (reward abnormalities, anxiety, depression) and thus participate to sustain the disease...
March 28, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29584612/elevated-serum-ca-19-9-with-adnexal-mass-is-it-always-an-ovarian-malignancy
#13
Kah Teik Chew, Izyan Atiqah Zakaria, Muhammad Azrai Abu, Mohd Faizal Ahmad, Erica Yee Hing, Nur Azurah Abdul Ghani
Endometriotic cysts a common benign gynaecological disease in women of reproductive age. We report an unusual case of ruptured endometrioma associated with increased CA 19-9. A 27-year-old woman presented with an acute abdomenal adnexal mass and elevated CA 19-9. The initial diagnosis of ovarian malignancy turned out to be a ruptured endometrioma, confirmed during surgery and in the histopathological report.
March 27, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29558345/irisin-and-myostatin-responses-to-acute-high-intensity-interval-exercise-in-humans
#14
Banu Kabak, Muaz Belviranli, Nilsel Okudan
Background The purpose of this study was to investigate irisin and myostatin responses to acute high-intensity interval exercise. Materials and methods Ten male professional kick-boxers aged between 18 and 24 years and 10 sedentary males with similar age and body weight participated in the present study. Participants performed 4 × 30-s Wingate test separated with 4 min of rest. Blood samples were taken immediately before and after exercise, and 3 and 6 h of recovery. Results and conclusion At rest, irisin levels were higher in the kick-boxers (p < 0...
March 20, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29558344/a-positive-urine-pregnancy-test-upt-with-adnexal-mass-ectopic-pregnancy-is-not-the-ultimate-diagnosis
#15
Mohd Faizal Ahmad, Muhammad Azrai Abu, Kah Teik Chew, Kun Leng Sheng, Mohd Asyraf Zakaria
A positive urine pregnancy test (UPT) with adnexal mass in ectopic pregnancy is not the ultimate diagnosis. The incidence of ectopic pregnancy is about 27 per 1000 pregnancies [1]. On average, about 6-16% will present to an emergency department with first-trimester bleeding and abdominal pain [2]. On presenting with these symptoms with the simultaneous presence of an adnexal mass and an empty uterus, a UPT is of paramount importance to determine whether the symptoms are pregnancy related or not. When the UPT is positive, an ectopic pregnancy is not the only diagnosis as the rare entity of non-gestational ovarian choriocarcinoma (NGOC) should be considered...
March 20, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29547393/obesity-associated-disease-risk-the-role-of-inherent-differences-and-location-of-adipose-depots
#16
Jessica H Hill, Claudia Solt, Michelle T Foster
Obesity and associated metabolic co-morbidities are a worldwide public health problem. Negative health outcomes associated with obesity, however, do not arise from excessive adiposity alone. Rather, deleterious outcomes of adipose tissue accumulation are a result of how adipocytes are distributed to individual regions in the body. Due to our increased understanding of the dynamic relationship that exists between specific adipose depots and disease risk, an accurate characterization of total body adiposity as well as location is required to properly evaluate a population's disease risk...
March 16, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29547392/visceral-adipose-tissue-in-patients-with-severe-mental-illness
#17
REVIEW
Kai G Kahl, Michael Deuschle, Brendon Stubbs, Ulrich Schweiger
Background Severe mental illnesses (SMIs), i.e. major depression, schizophrenia and bipolar disorder, are associated with an elevated risk for the development of type-2 diabetes mellitus and cardiovascular disorders. Several factors have been associated with increased cardiometabolic morbidity and mortality in SMI, including lifestyle factors (smoking, inactivity, unhealthy diet), endocrine and immunologic alterations; however, the underlying mechanisms remain to be fully uncovered. It is now well accepted that visceral adipose tissue (VAT) promotes the development of cardiometabolic disorders, at least in part by inflammatory and metabolic functions...
March 16, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29547391/the-association-between-irisin-levels-element-distribution-and-oxidative-stress-markers-in-adolescent-swimmers
#18
Muaz Belviranli, Nilsel Okudan, Nuran Karakuyu
The objective of this investigation was to compare irisin concentration and its relation with oxidative stress markers, antioxidant enzymes and element levels in both male adolescent swimmers and sedentary controls. Twelve male swimmers aged between 11 and 18 years, who performed regular swimming training for at least 2 years and 12 age- and gender-matched sedentary controls participated in this study. After anthropometric measurements were performed, fasting venous blood samples were taken at rest. Irisin, malondialdehyde (MDA) as a marker of oxidative stress, superoxide dismutase (SOD) as a marker of antioxidant enzyme and elements (Zn, Cu, Se, Cr, Ni, Al, Fe) were analyzed in these samples...
March 16, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29547390/the-origin-and-purpose-of-layers-of-subcutaneous-adipose-tissue-in-pigs-and-man
#19
REVIEW
Gary J Hausman
Adipose tissue exists in many locations or depots that differ from one another based on numerous and various characteristics. The unique "layered" anatomical feature of subcutaneous adipose tissue (SAT) in man and the pig is reviewed and discussed. The origin of fetal pig adipose tissue subcutaneous layers is reviewed before the onset of adipogenesis and after the overt adipogenesis. Furthermore, the distinguishing characteristics of developing outer SAT layer (OSQ) and middle SAT layer (MSQ) in pigs are reviewed...
March 16, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29547389/melatonin-has-a-protective-effect-against-lipid-peroxidation-in-the-bone-tissue-of-diabetic-rats-subjected-to-acute-swimming-exercise
#20
Mursel Bicer, Saltuk Bugra Baltaci, Suleyman Patlar, Rasim Mogulkoc, Abdulkerim Kasim Baltaci
Aim The present study aimed to examine the effects of melatonin supplementation on lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise. Methods The study was conducted on 80 Sprague-Dawley type adult male rats which were equally allocated to eight groups: group 1, general control; group 2, melatonin-supplemented control; group 3, melatonin-supplemented diabetic control; group 4, swimming control; group 5, melatonin-supplemented swimming; group 6, melatonin-supplemented diabetic swimming; group 7, diabetic swimming; group 8, diabetic control...
March 16, 2018: Hormone Molecular Biology and Clinical Investigation
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