journal
MENU ▼
Read by QxMD icon Read
search

Hormone Molecular Biology and Clinical Investigation

journal
https://www.readbyqxmd.com/read/30398970/the-effects-of-estradiol-and-testosterone-on-renal-tissues-oxidative-after-central-injection-of-angiotensin-ii-in-female-doca-salt-treated-rats
#1
Marzieh Kafami, Mahmoud Hosseini, Saeed Niazmand, Esmaeil Farrokhi, Mosa Al-Reza Hajzadeh, Samad Nazemi
Background Although numerous studies have proven that estrogen (Est) has a protective effect on the development of hypertension, more research needs to be done to show its detailed mechanism in a variety of hypertension. The important role of active oxygen species in blood pressure is well defined. We examined whether or not sex hormones change the growth of reactive oxygen species (ROS) ‎in kidneys after central microinjection of angiotensin II (Ang II).‎ Materials and methods Female Wistar rats, 8 weeks old (200 ± 10 g) were used in this study...
November 6, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30367794/copper-and-zinc-in-stage-i-multiple-myeloma-relation-with-ceruloplasmin-lipid-peroxidation-and-superoxide-dismutase-activity
#2
Mohammad-Hassan Khadem-Ansari, Mojtaba Asoudeh, Hosein Fallahi Kord Gheshlaghi, Samira Nozari, Mina Zarringol, Nazila Fathi Maroufi, Yousef Faridvand
Background The main aim of this study was to assess the serum levels of copper (Cu), zinc (Zn) with lipid peroxidation, Cu/Zn superoxide dismutase (Cu/Zn SOD) activity, and ceruloplasmin (Cp) in multiple myeloma (MM) patients. Materials and methods The study was conducted in 34 MM patients at stage I. Serum Cu and Zn levels were measured by atomic absorption spectrometry. Also, spectrophotometric assays of malondialdehyde (MDA) levels in addition to Cp and Cu/Zn SOD were quantitated. Results The results showed a significant decrease in the serum Zn levels in patients with MM (p < 0...
October 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30367793/exercise-training-increases-cardiac-hepatic-and-circulating-levels-of-brain-derived-neurotrophic-factor-and-irisin-in-young-and-aged-rats
#3
Muaz Belviranlı, Nilsel Okudan
Background The objective of study was to examine the impacts of exercise training on cardiac, hepatic and plasma brain-derived neurotrophic factor (BDNF) and irisin levels in young and aged rats. Materials and methods Four-month-old (young) and 20-month-old (aged) female rats performed exercise training consisting of voluntary wheel running for 12 weeks. BDNF and irisin levels were analyzed in the heart, liver and plasma samples by using commercially available enzyme-linked immunosorbent assay (ELISA) kits...
October 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30367792/hypothyroidism-and-nonalcoholic-fatty-liver-disease-a-chance-association
#4
REVIEW
Simonetta Lugari, Alessandro Mantovani, Fabio Nascimbeni, Amedeo Lonardo
Background Nonalcoholic fatty liver disease (NAFLD) defines the clinical-pathological spectrum of hepatic lipotoxicity, which may progress to hepatic fibrosis and its complications. Thyroid hormone is a master regulator of cell metabolism and body fat distribution. Whether hypothyroidism is associated or not with an increased risk of developing NAFLD and its fibrotic progression is both clinically and physiopathologically relevant. Indeed, answering this research question would carry major pathogenic and therapeutic implications...
October 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30367791/clinical-relevance-in-present-day-hormonal-contraception
#5
REVIEW
Pedro-Antonio Regidor
The contraceptive pill is an effective and very safe method to control pregnancies. It was developed 60 years ago, and despite that the composition has been the same since it was first developed (estrogen and progestogen), over the years the concentration of ethinyl estradiol has been reduced to improve tolerability. Nevertheless, progestogens are the basic active agent of hormonal contraception. The mechanism of progestogens is a multimodal one and basically three modes of contraceptive action can be distinguished: (a) A strong antigonadotrophic action leading to the inhibition of ovulation...
October 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30256758/the-response-of-meteorin-like-hormone-and-interleukin-4-in-overweight-women-during-exercise-in-temperate-warm-and-cold-water
#6
Marziyeh Saghebjoo, Afsaneh Einaloo, Mehdi Mogharnasi, Fereshteh Ahmadabadi
Background Meteorin-like hormone (Metrnl) and interleukin-4 (IL-4) are protein molecules that stimulate the production of brown adipose tissue to improve diseases such as type 2 diabetes and obesity. The aim of this study was to investigate the response of Metrnl protein and IL-4 in overweight women during exercise in temperate, warm and cold water. Materials and methods Thirteen overweight young women (mean age 25.21 ± 3.27 years, body mass index 26.43 ± 1.34 kg/m2) were selected randomly and performed three sessions of interval exercise (40 min per session, 65% of maximum oxygen consumption) in non-consecutive days in temperate (24-25 °C), warm (36...
September 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30256757/effect-of-experimentally-induced-hypothyroidism-during-gestation-period-on-activity-dependent-neurotrophic-factor-adnf-in-newborn-rat-brain-tissue
#7
Gökhan Cesur, Mehtap Kılıç Eren, Erdal Eren, Kemal Ergin, Rauf Onur Ek, Yüksel Yıldız, Ferhat Şirinyıldız, Umut Gök Balcı, Kurtulus Ongel
Purpose The aim of the study was to evaluate the effects of prenatal hypothyroidism on neonatal rats by the way of activity-dependent neuroprotective factor (ADNF) expression. Methods Twenty-one Wistar albino neonatal rats were divided into two subgroups; a control group and neonatal rats with experimental maternal hypothyroidism. Hypothyroidism was induced by using propylthiouracil (PTU). Neonatal rats obtained PTU from breast milk continuously for 1 week after birth. The rats from the control group were fed only normal feed and water...
September 26, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30205641/cross-sectional-correlates-of-nesfatin-and-lipopolysaccharide-binding-protein-in-metabolic-syndrome-patients-with-and-without-prediabetes
#8
Safa'a Ali Al-Qudah, Violet Kasabri, Mohammad Issa Saleh, Maysa Suyagh, Sundos AlAlawi, Nada Yasin
No abstract text is available yet for this article.
September 6, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30171810/metalloproteinases-in-non-alcoholic-fatty-liver-disease-and-their-behavior-in-liver-fibrosis
#9
REVIEW
Magalí Barchuk, Laura Schreier, Gabriela Berg, Verónica Miksztowicz
No abstract text is available yet for this article.
September 1, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30120909/the-choice-of-progestogen-for-hrt-in-menopausal-women-breast-cancer-risk-is-a-major-issue
#10
REVIEW
Xiangyan Ruan, Alfred O Mueck
No abstract text is available yet for this article.
August 18, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30218603/the-influence-of-thyroid-disorders-on-bone-density-and-biochemical-markers-of-bone-metabolism
#11
Konstantinos Tsevis, Eftihios Trakakis, Vasilios Pergialiotis, Eleni Alhazidou, Melpomeni Peppa, Charalampos Chrelias, Nikolaos Papantoniou, Periklis Panagopoulos
Background Thyroid dysfunction, predominantly hyperthyroidism, has been previously linked to impaired bone mass density (BMD) and increased risk of fractures. On the other hand, data in the field of hypothyroidism (HT) are missing. The purpose of the present study was to investigate the impact of thyroid disorders on bone density serum and urine calcium (Ca) and phosphate (P) as well as serum osteocalcin and alkaline phosphatase and urine hydroxyproline in a series of post-menopausal women. Materials and methods The study was conducted in the Reproductive Endocrinology Outpatient Clinic of our hospital...
September 15, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30205658/comparison-of-performing-12-weeks-resistance-training-before-after-and-or-in-between-aerobic-exercise-on-the-hormonal-status-of-aged-women-a-randomized-controlled-trial
#12
RANDOMIZED CONTROLLED TRIAL
Ebrahim Banitalebi, Mohammad Faramarzi, Laleh Bagheri, Abdol Reza Kazemi
Background Physiological aging can now be considered as a multi-factorial process that is associated with anatomical and signaling changes associated with endocrine function. The purpose of this study was to investigate the comparison of performing 12 weeks' resistance training before, after and/or in between aerobic exercise on the hormonal status of aged women. Materials and methods Forty healthy aged women (age: 67.35 ± 1.40 years) were randomly divided into three training groups and a control group: resistance followed by endurance training (ER, n = 12), endurance training followed by resistance training (RE, n = 12, interval resistance-endurance (RE) training (INT, n = 12) and a control (Con, n = 12) groups...
September 8, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30144385/kjell-carlstr%C3%A3-m-1940-2018
#13
Gunnar Söderqvist, Eva Lundström
No abstract text is available yet for this article.
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30144384/congenital-complete-heart-block-in-pregnancy
#14
Nurul Iftida Basri, Shuhaila Ahmad
Complete heart block (CHB) is infrequently encountered during pregnancy. Its management requires a multidisciplinary approach involving the obstetrician, cardiologist, anesthetist and neonatologist. It varies from conservative, temporary or permanent pacemaker (PPM) insertion (either during the antenatal, intrapartum or postpartum period). We present the case of a 30-year-old, gravida 2 para 1 at the 36-week period of amenorrhea (POA) with congenital CHB. She was asymptomatic throughout her pregnancy despite having a pulse rate between 40 and 50 beats per minute...
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30144383/endometrial-injury-for-patients-with-endometriosis-and-polycystic-ovary-syndrome-undergoing-medically-assisted-reproduction-current-data-and-a-protocol
#15
Charalampos Siristatidis, Ioannis Rigos, Vasilios Pergialiotis, Vasilios Karageorgiou, Nikolaos Christoforidis, George Daskalakis, Stefano Bettocchi, Antonis Makrigiannakis
We propose a study protocol capable of improving clinical outcomes following medically assisted reproduction (MAR) in infertile women with endometriosis and polycystic ovary syndrome (PCOS). The proposed research derives from the published evidence on the positive impact from endometrial injury (EI) and the beneficial nature of the intervention towards improved implantation rates. We primarily refer to the cluster of events and hypotheses, such as the mechanical cascade, the inflammatory response per se, the events accompanying wound healing, the immune cell recruitment and protein involvement, alterations in gene expression and the neo-angiogenesis theories, which have been previously investigated for this purpose...
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30144382/dehydroepiandrosterone-and-or-its-metabolites-possible-androgen-receptor-antagonistic-effects-on-digitized-mammographic-breast-density-in-normal-breast-tissue-of-postmenopausal-women
#16
Eva Lundström, Kjell Carlström, Sabine Naessen, Gunnar Söderqvist
Background Androgens, notably testosterone inhibit breast cell proliferation and negative correlations between free testosterone (fT) and breast cell proliferation as well as mammographic density have been described. Dehydroepiandrosterone (DHEA) is reported to be a partial androgen antagonist in breast tumor cells in vitro. Our aim was to investigate if circulating DHEA had any effects on the association between circulating fT and mammographic density in vivo in the normal postmenopausal breast. Methods We measured visual and digitized mammographic density and serum DHEA, testosterone, sex-hormone-binding globulin and calculated fT in 84 healthy untreated postmenopausal women...
August 25, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30098285/the-diagnostic-challenge-of-ovarian-carcinoma-in-normal-sized-ovaries-a-report-of-two-cases
#17
Soon Leong Yong, Safilah Dahian, Aznim Hani Ramlan, Marcus Kang
Normal-sized ovarian carcinoma syndrome (NOCS) is a rare condition characterised by malignancy identified in ovaries of normal size with abdominal metastasis. We report two cases of advanced ovarian carcinoma with ovaries of normal size. The first case was a 13-year-old adolescent with malignant ascites and bilateral normal sized multicystic ovaries detected on ultrasound. Serum cancer antigen 125 (CA 125) and lactate dehydrogenase were markedly raised. A computed tomography (CT) scan showed the presence of thick omental cake but no ovarian tumour...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30098284/studying-non-alcoholic-fatty-liver-disease-the-ins-and-outs-of-in-vivo-ex-vivo-and-in-vitro-human-models
#18
REVIEW
Charlotte J Green, Siôn A Parry, Pippa J Gunn, Carlo D L Ceresa, Fredrik Rosqvist, Marie-Eve Piché, Leanne Hodson
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. Determining the pathogenesis and pathophysiology of human NAFLD will allow for evidence-based prevention strategies, and more targeted mechanistic investigations. Various in vivo, ex situ and in vitro models may be utilised to study NAFLD; but all come with their own specific caveats. Here, we review the human-based models and discuss their advantages and limitations in regards to studying the development and progression of NAFLD. Overall, in vivo whole-body human studies are advantageous in that they allow for investigation within the physiological setting, however, limited accessibility to the liver makes direct investigations challenging...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30098283/reciprocal-role-of-hbd2-and-hbd3-on-the-adaptive-immune-response-by-measuring-t-lymphocyte-proliferation-in-terms-of-cd4-and-ccr6-expression
#19
Nima Taefehshokr, Alireza Isazadeh, Amin Oveisi, Yashar Azari Key, Sina Taefehshokr
Background Human β-defensins (hBD2 and hBD3) are small cationic antimicrobial peptides of innate immune system which can act as a barrier against the majority of pathogens, contributing to the host immune defence. Objective The aim of study is to determine whether hBD2 and hBD3 play a role in development and proliferation of human effector CD4 T cells or not. Furthermore, if enhanced proliferation is observed in the presence of hBD2 and hBD3, these data will demonstrate whether chemokine receptor type 6 (CCR6) is required to be present for this activity to occur...
August 11, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/30063464/choice-of-progestogen-for-endometrial-protection-in-combination-with-transdermal-estradiol-in-menopausal-women
#20
REVIEW
Alfred O Mueck, Thomas Römer
Transdermal estradiol (TE) application (using gels, patches or a novel spray) is now a preferred route of hormone therapy (HT) in menopausal women, because various risks such as venous thromboembolism, stroke and unwanted hepatic effects can be reduced compared with oral HT. However, in the presence of an intact uterus, concurrent administration of progestogen is needed for endometrial protection. Due to the variety of progestogens available and differences in their clinical effects, the selection of the most appropriate substance and dosing for individual combination therapy can be difficult...
July 31, 2018: Hormone Molecular Biology and Clinical Investigation
journal
journal
43220
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"