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Hormone Molecular Biology and Clinical Investigation

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https://www.readbyqxmd.com/read/28525362/fgf21-receptor-agonists-an-emerging-therapeutic-class-for-obesity-related-diseases
#1
Junichiro Sonoda, Mark Z Chen, Amos Baruch
Fibroblast growth factor 21 (FGF21) analogs and FGF21 receptor agonists (FGF21RAs) that mimic FGF21 ligand activity constitute the new "FGF21-class" of anti-obesity and anti-diabetic molecules that improve insulin sensitivity, ameliorate hepatosteatosis and promote weight loss. The metabolic actions of FGF21-class proteins in obese mice are attributed to stimulation of brown fat thermogenesis and increased secretion of adiponectin. The therapeutic utility of this class of molecules is being actively investigated in clinical trials for the treatment of type 2 diabetes and non-alcoholic steatohepatitis (NASH)...
May 19, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28475489/differential-modulation-of-innate-immune-response-by-epinephrine-and-estradiol
#2
Sona Margaryan, Armenuhi Hyusyan, Anush Martirosyan, Shushan Sargsian, Gayane Manukyan
Background Although it is widely accepted that catecholamines and estrogens influence immunity and have consequences for health, their effect on innate immunity (e.g. monocytes and neutrophils) is still not fully investigated. Materials and methods Our study aimed to analyze the production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, monocyte chemoattractant protein (MCP)-1 and IL-8 by whole blood cells following short-term exposure to epinephrine (Epi) and 17β-estradiol (E2) in the presence or absence of lipopolysaccharide (LPS)...
May 5, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28333653/association-of-transient-hyperthyroidism-and-severity-of-hyperemesis-gravidarum
#3
Nor Zila Hassan Malek, Aida Kalok, Zainal Abidin Hanafiah, Shamsul Azhar Shah, Nor Azlin Mohamed Ismail
Background Transient non-immune hyperthyroidism in early pregnancy is hyperthyroidism diagnosed for the first time in early pregnancy, without evidence of thyroid autoimmunity or clinical findings of Grave's disease and resolved spontaneously as the pregnancy progressed. Hyperemesis gravidarum (HG) is the commonest cause with 66%-73% of women with severe HG were found to have elevated thyroid function. Materials and methods We conducted a cross sectional study to determine the prevalence of transient hyperthyroidism in patients with hyperemesis gravidarum and its relation to the severity of nausea and vomiting...
March 23, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28222027/vitamin-d-modulates-the-expression-of-hla-dr-and-cd38-after-in-vitro-activation-of-t-cells
#4
Simon Villegas-Ospina, Wbeimar Aguilar-Jimenez, Sandra M Gonzalez, María T Rugeles
OBJECTIVE: Vitamin D (VitD) is an anti-inflammatory hormone; however, some evidence shows that VitD may induce the expression of activation markers, such as CD38 and HLA-DR. We explored its effect on the expression of these markers on CD4+ and CD8+ T-cells in vitro, and their potential correlations in vivo. MATERIALS AND METHODS: CD38 and HLA-DR expression was measured by flow cytometry in PHA/IL-2-activated mononuclear cells cultured under VitD precursors: three cholecalciferol (10-11M, 10-9M, 10-7M; n=11) and two calcidiol (40 ng/mL, 80 ng/mL; n=9) concentrations...
March 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28157691/the-effect-of-alfacalcidiol-and-metformin-on-metabolic-disturbances-in-women-with-polycystic-ovary-syndrome
#5
RANDOMIZED CONTROLLED TRIAL
Jana Figurová, Ingrid Dravecká, Jana Petríková, Martin Javorský, Ivica Lazúrová
BACKGROUND: The aim of this randomized clinical trial (RCT) was to evaluate the effect of vitamin D supplementation in obese, insulin-resistant (IR) and vitamin D-deficient polycystic ovary syndrome (PCOS) women on metabolic abnormalities in comparison to the effect of metformin or combined metformin plus vitamin D therapy. MATERIAL AND METHODS: Thirty-nine PCOS women who fulfilled the inclusion criteria were randomized into three groups and treated with alfacalcidiol, combined alfacalcidiol and metformin therapy and metformin for 6 months...
March 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28099123/hyperandrogenemia-in-women-with-polycystic-ovary-syndrome-prevalence-characteristics-and-association-with-body-mass-index
#6
Eleni Alexiou, Erifili Hatziagelaki, Vasilios Pergialiotis, Charalampos Chrelias, Dimitrios Kassanos, Charalampos Siristatidis, Giannoula Kyrkou, Maria Kreatsa, Eftihios Trakakis
BACKGROUND: Hyperandrogenemia is one of the major diagnostic features for the diagnosis of polycystic ovary syndrome (PCOS). The aim of this study was to estimate the prevalence and the characteristics of hyperandrogenemia in women with PCOS and to investigate the association of clinical and biochemical characteristics with body mass index (BMI) according to the presence of hyperandrogenemia. MATERIALS AND METHODS: We studied 266 women diagnosed with PCOS. Hyperandrogenemia was defined by testosterone (T) and/or free testosterone (FT) and/or ∆4 androstenedione (Δ4-A) higher than 75% of the upper limits of each hormone...
March 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27416617/hypomagnesaemia-a-modifiable-risk-factor-of-diabetic-nephropathy
#7
RANDOMIZED CONTROLLED TRIAL
Sonny Bherwani, Srushtee Bipin Jibhkate, A S Saumya, Sitendu Kumar Patel, Ritu Singh, L H Ghotekar
BACKGROUND: Diabetes mellitus (DM) is a heterogeneous disease characterised by an absolute or relative deficiency of insulin and insulin resistance. Diabetes is occurring at younger age in India. It is estimated that 20% of the type 2 DM patients reach end-stage renal disease (ESRD) during their lifetime. Recently, it has been proposed that hypomagnesaemia is a novel factor implicated in the pathogenesis of diabetic complications. Considering this, a study was designed to estimate the prevalence and association of hypomagnesaemia with diabetic nephropathy in North Indian population...
March 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27997350/a-low-dose-6-5-mg-of-intravaginal-dhea-permits-a-strictly-local-action-while-maintaining-all-serum-estrogens-or-androgens-as-well-as-their-metabolites-within-normal-values
#8
RANDOMIZED CONTROLLED TRIAL
Fernand Labrie, Céline Martel
OBJECTIVE: Serum concentrations of estradiol (E2) and testosterone (testo) measured by mass spectrometry-based assays should remain below the 95th centile measured at 9.3 pg/mL for E2 and 0.26 ng/mL for testo in normal postmenopausal women in order to avoid the risk of non-physiological systemic exposure to elevated serum concentrations of these two sex steroids. METHODS: Serum E2 and testo, as well as dehydroepiandrosterone (DHEA) and nine of its other metabolites, were measured at 10 time intervals over 24 h on the first and seventh days of daily intravaginal administration of 0...
February 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27802175/neurotransmitter-alteration-in-a-testosterone-propionate-induced-polycystic-ovarian-syndrome-rat-model
#9
Nirja K Chaudhari, Laxmipriya P Nampoothiri
BACKGROUND: Polycystic ovarian syndrome (PCOS), one of the leading causes of infertility seen in women, is characterized by anovulation and hyperandrogenism, resulting in ovarian dysfunction. In addition, associations of several metabolic complications like insulin resistance, obesity, dyslipidemia and psychological co-morbidities are well known in PCOS. One of the major factors influencing mood and the emotional state of mind is neurotransmitters. Also, these neurotransmitters are very crucial for GnRH release...
February 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27505093/thiol-disulfide-parameters-as-a-novel-oxidative-marker-in-medical-labor-induction-with-oxytocin
#10
COMPARATIVE STUDY
Ozlem Gun Eryilmaz, Hatice Kansu-Celik, Ozcan Erel, Serpil Erdogan
BACKGROUND: The aim of this study was to analyze the alterations in thiol levels among mothers and neonates who were prone to medical oxytocin induction. MATERIALS AND METHODS: A total of 40 pregnant women who underwent medical labor induction with oxytocin (Group A) were compared with 53 women whose labor progressed spontaneously without any kind of induction (Group B). We measured the thiol/disulfide homeostasis parameters (native thiol, total thiol, disulfide, disulfide/total thiol, disulfide/native thiol) of maternal and cord blood...
February 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27318657/primary-umbilical-endometriosis-successfully-treated-with-dienogest
#11
Kah Teik Chew, Salim Norsaadah, Aziz Suraya, Erica Yee Hing, Zainuddin Ani Amelia, Mohd Ismail Nor Azlin, Abdul Ghani Nur Azurah
Primary umbilical endometriosis (PUE) is a rare gynaecological disorder. A majority of the reported cases were treated with surgical excision as medical treatment had been found to be less successful. We reported a case of PUE successfully treated with dienogest without any profound side effects from the drug.
February 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28099124/browning-of-white-adipose-tissue-lessons-from-experimental-models
#12
Thereza Cristina Lonzetti Bargut, Vanessa Souza-Mello, Marcia Barbosa Aguila, Carlos Alberto Mandarim-de-Lacerda
Beige or brite (brown-in-white) adipocytes are present in white adipose tissue (WAT) and have a white fat-like phenotype that when stimulated acquires a brown fat-like phenotype, leading to increased thermogenesis. This phenomenon is known as browning and is more likely to occur in subcutaneous fat depots. Browning involves the expression of many transcription factors, such as PR domain containing 16 (PRDM16) and peroxisome proliferator-activated receptor (PPAR)-γ, and of uncoupling protein (UCP)-1, which is the hallmark of thermogenesis...
January 18, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28085671/exercise-induced-effects-on-ucp1-expression-in-classical-brown-adipose-tissue-a-systematic-review
#13
Andreas D Flouris, Petros C Dinas, Angelica Valente, Cláudia Marlise Balbinotti Andrade, Nair Honda Kawashita, Paraskevi Sakellariou
Understanding the impact of regular exercise training on uncoupling protein 1 (UCP1) activity in classical brown adipose tissue (CBAT) is vital to our knowledge of whole-body thermogenic activity. The purpose of this systematic review was to evaluate the available experimental evidence on the effect of regular exercise training on UCP1 expression in CBAT. We performed a literature search using PubMed (1966-2016), Scopus, and EMBASE (1974-2016). Studies in any language that examined the effect of regular exercise training on UCP1 expression in CBAT, and not white adipose tissue (WAT), were eligible...
January 13, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28222028/expression-purification-and-characterization-of-human-cytosolic-sulfotransferase-sult-1c4
#14
Amber L Guidry, Zachary E Tibbs, Melissa Runge-Morris, Charles N Falany
Human cytosolic sulfotransferase 1C4 (hSULT1C4) is a dimeric Phase II drug-metabolizing enzyme primarily expressed in the developing fetus. SULTs facilitate the transfer of a hydrophilic sulfonate moiety from 3'-phosphoadenosine-5'-phosphosulfate (PAPS) onto an acceptor substrate altering the substrate's biological activity and increasing the compound's water solubility. While several of the hSULTs' endogenous and xenobiotic substrates have been identified, the physiological function of hSULT1C4 remains unknown...
January 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27831918/17%C3%AE-estradiol-suppresses-visceral-adipogenesis-and-activates-brown-adipose-tissue-specific-gene-expression
#15
Saad Misfer Al-Qahtani, Galyna Bryzgalova, Ismael Valladolid-Acebes, Marion Korach-André, Karin Dahlman-Wright, Suad Efendić, Per-Olof Berggren, Neil Portwood
Both functional ovaries and estrogen replacement therapy (ERT) reduce the risk of type 2 diabetes (T2D). Understanding the mechanisms underlying the antidiabetic effects of 17β-estradiol (E2) may permit the development of a molecular targeting strategy for the treatment of metabolic disease. This study examines how the promotion of insulin sensitivity and weight loss by E2 treatment in high-fat-diet (HFD)-fed mice involve several anti-adipogenic processes in the visceral adipose tissue. Magnetic resonance imaging (MRI) revealed specific reductions in visceral adipose tissue volume in HFD+E2 mice, compared with HFD mice...
January 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27740917/comment-on-is-there-a-role-for-vitamin-d-in-human-reproduction
#16
Francesca Colonese, Valentina Lucia La Rosa, Antonio Simone Laganà, Salvatore Giovanni Vitale, Diego Cortinovis, Paolo Bidoli
No abstract text is available yet for this article.
January 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27269896/the-evolution-of-genomic-stability-to-a-mechanism-in-reproduction-and-psychiatry
#17
REVIEW
Pedro-Antonio Regidor, Claus D Volko, Adolf E Schindler, Uwe D Rohr
There are two forms of immune defense, the specific or adaptive immune defense and the unspecific innate immune defense. Vaccination is utilized against specific bacteria via the adaptive immune system. The innate immunity DNA stress defense is a non-toxic mechanism developed in yeasts and conserved in mammals and in plants. Although the steroidal hormone cascade has overtaken the stress response and allows superfast response via non-genomic receptors, the old innate immunity response is still mediated via the steroidal hormones cascade...
January 1, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27902451/vitamin-d-and-male-reproductive-system
#18
REVIEW
Pablo R Costanzo, Pablo Knoblovits
Vitamin D deficiency is a highly prevalent worldwide condition and affects people of all ages. The most important role of vitamin D is the regulation of intestinal calcium absorption and metabolism of calcium and phosphorus to maintain muscle and bone homeostasis. Furthermore, in recent years it has been discovered that the vitamin D receptor (VDR) is widely distributed in many organs and tissues where vitamin D can perform other actions that include the modulation of the immune response, insulin secretion, anti-proliferative effect on cells of vascular smooth muscle, modulation of the renin-angiotensin-aldosterone system and regulates cell growth in several organs...
December 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27665425/effects-of-obesity-treatments-on-bone-mineral-density-bone-turnover-and-fracture-risk-in-adults-with-overweight-or-obesity
#19
REVIEW
Claudia Harper, Andrea L Pattinson, Hamish A Fernando, Jessica Zibellini, Radhika V Seimon, Amanda Sainsbury
BACKGROUND: New evidence suggests that obesity is deleterious for bone health, and obesity treatments could potentially exacerbate this. MATERIALS AND METHODS: This narrative review, largely based on recent systematic reviews and meta-analyses, synthesizes the effects on bone of bariatric surgery, weight loss pharmaceuticals and dietary restriction. RESULTS AND CONCLUSIONS: All three obesity treatments result in statistically significant reductions in hip bone mineral density (BMD) and increases in bone turnover relative to pre-treatment values, with the reductions in hip BMD being strongest for bariatric surgery, notably Roux-en Y gastric bypass (RYGB, 8%-11% of pre-surgical values) and weakest for dietary restriction (1%-1...
December 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27092656/adipose-derived-stem-cells-for-regenerative-therapy-in-osteoarticular-diseases
#20
REVIEW
Yves-Marie Pers, Christian Jorgensen
In the recent years, adipose derived stem cells (ASCs) led to significant findings in the field of regenerative therapy. ASCs have various biological properties and capacity as differentiation in three lineages (chondrocytes, osteocytes and adipocytes) or immunomodulation by releasing paracrine factors. Osteoarthritis (OA) is the most frequent osteoarticular disease characterized by none curative treatment. We reviewed all current data on the proof of concept of ASCs in OA pathophysiology as well as an inventory of ASC promising cell therapy in OA...
December 1, 2016: Hormone Molecular Biology and Clinical Investigation
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