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Journal of Osteoporosis

V V Povoroznyuk, N V Grygorieva, J A Kanis, E V McCloskey, H Johansson, S S Strafun, M O Korzh, V M Vaida, F V Klymovytsky, V S Forosenko, R O Vlasenko
Worldwide, the number of hip fractures, the most important osteoporotic complication in the elderly, continues to increase in line with the ageing of the population. In some countries, however, including the Ukraine, data on the incidence of hip fracture are limited. This article describes the first analysis to characterize the incidence of hip fracture in the Ukrainian population from the age of 40 years. It is based on data from two regional studies, namely, the Vinnitsa city study and the STOP study, which were performed during 1997-2002 and 2011-2012 years, respectively...
2018: Journal of Osteoporosis
Nahid J Rianon, Scott M Smith, MinJae Lee, Hannah Pervin, Paul Musgrave, Gordon P Watt, Shahla Nader, Sundeep Khosla, Catherine G Ambrose, Joseph B McCormick, Susan P Fisher-Hoch
Altered bone quality, caused by underlying metabolic changes of type 2 diabetes (T2D), has been hypothesized to cause altered bone strength and turnover leading to increased fracture risk in T2D patients. Current understanding about changes in bone turnover markers in T2D patients is mainly based on studies focused on Caucasian men and women. However, Hispanic populations have the highest prevalence of both T2D and osteoporosis in the US. We investigated associations of glycemic control (in terms of glycated hemoglobin [HbA1c]) and bone turnover rate in 69 older (≥50 years) Mexican American Cameron County Hispanic Cohort (CCHC) participants with T2D...
2018: Journal of Osteoporosis
Journal Of Osteoporosis
[This corrects the article DOI: 10.1155/2012/528790.].
2018: Journal of Osteoporosis
Annesofie L Jensen, Gitte Wind, Bente Lomholt Langdahl, Kirsten Lomborg
Introduction: Patients with chronic diseases like osteoporosis constantly have to make decisions related to their disease. Multifaceted osteoporosis group education (GE) may support patients' decision-making. This study investigated multifaceted osteoporosis GE focusing on the impact of GE on patients' decision-making related to treatment options and lifestyle. Material and Methods: An interpretive description design using ethnographic methods was utilized with 14 women and three men diagnosed with osteoporosis who attended multifaceted GE...
2018: Journal of Osteoporosis
Bhavna Daswani, M Ikram Khatkhatay
Postmenopausal osteoporosis (PMO) is a result of increased bone resorption compared to formation. Osteoclasts are responsible for bone resorption, which are derived from circulating monocytes that undertake a journey from the blood to the bone for the process of osteoclastogenesis. In recent times, the use of high throughput technologies to explore monocytes from women with low versus high bone density has led to the identification of candidate molecules that may be deregulated in PMO. This review provides a list of molecules in monocytes relevant to bone density which have been identified by "omics" studies in the last decade or so...
2018: Journal of Osteoporosis
Athanasios Karpouzos, Evangelos Diamantis, Paraskevi Farmaki, Spyridon Savvanis, Theodore Troupis
Introduction: Fractures are quite common, especially among the elderly. However, they can increase in prevalence in younger ages too if the bone health is not good. This may happen as a result of bad nutrition. Methods: A customized, retrospective review of available literature was performed using the following keywords: bone health, nutrition, and fractures. Results: Insufficient intake of certain vitamins, particularly A and D, and other nutrients, such as calcium, may affect bone health or even the time and degree of bone healing in case of fracture...
2017: Journal of Osteoporosis
Joonas Sirola, Manuel Diaz Curiel, Risto Honkanen, Jun Iwamoto
[This corrects the article DOI: 10.4061/2011/582789.].
2017: Journal of Osteoporosis
Ville Juhana Waris, Joonas P Sirola, Vesa V Kiviniemi, Marjo T Tuppurainen, V Pekka Waris
[This corrects the article DOI: 10.4061/2011/732560.].
2017: Journal of Osteoporosis
Katherine Neubecker, Beverley Adams-Huet, Irfan M Farukhi, Rosinda Castanon, Ugis Gruntmanis
[This corrects the article DOI: 10.4061/2011/924595.].
2017: Journal of Osteoporosis
Inbar Hillel, Itzhak Binderman, Yifat Sarda, Uri Nevo
Osteoporosis is characterized by reduction in trabecular bone in conjunction with increased marrow cell adiposity. While these changes occur within weeks, monitoring of treatment efficacy as performed by DEXA is sensitive only to long-term changes. MRI is sensitive to bone marrow changes but is less affordable. In a recent study, we have shown that a stray-field NMR can monitor bone marrow cellular changes that are related to osteoporosis. Objectives. To demonstrate sensitivity of a low-field tabletop NMR scanner to bone marrow dynamics following hormonal treatment in rats...
2017: Journal of Osteoporosis
Miyako Suzuki, Magali Millecamps, Lina Naso, Seiji Ohtori, Chisato Mori, Laura S Stone
Although the pathological changes in osteoporotic bones are well established, the characterization of the osteoporotic pain and its appropriate treatment are not fully elucidated. We investigated the behavioral signs of cutaneous and deep musculoskeletal pain and physical function; time-dependent changes in bone mineral density (BMD) and the emergence of the behavioral phenotype; and the effects of pharmacological interventions having different mechanisms of action (chronic intraperitoneal administration of pamidronate [0...
2017: Journal of Osteoporosis
Saulo Martelli, Hossein Mokhtarzadeh, Peter Pivonka, Peter R Ebeling
Physical activity is recommended to prevent age-related bone loss. However, the proximal femur mechanoresponse is variable, possibly because of a muscle-dependant mechanoresponse. We compared the proximal femur response with the femoral strain pattern generated by the hip extensor muscles. A healthy participant underwent a six-month unilateral training of the hip extensor muscles using a resistance weight regularly adjusted to the 80% of the one-repetition maximum weight. DXA-based measurements of the areal Bone Mineral Density (aBMD) in the exercise leg were adjusted for changes in the control leg...
2017: Journal of Osteoporosis
Kok-Yong Chin
Aspirin is a cyclooxygenase inhibitor commonly used in primary prevention of cardiovascular diseases and cancers. Its users are elderly population susceptible to osteoporosis. It also inhibits the synthesis of prostaglandin E2 essential in bone remodeling. This prompts the question whether it can influence bone health among users. This review aimed to summarize the current literature on the use of aspirin on bone health. A literature search on experimental and clinical evidence on the effects of aspirin on bone health was performed using major scientific databases...
2017: Journal of Osteoporosis
Kirsti Uusi-Rasi, Radhika Patil, Saija Karinkanta, Kari Tokola, Pekka Kannus, Harri Sievänen
Introduction. Osteoarthritis (OA) of the hip is one of the major causes of pain and disability in the older population. Although exercise is an effective treatment for knee OA, there is lack of evidence regarding hip OA. The aim of this trial was to test the safety and feasibility of a specifically designed exercise program in relieving hip pain and improving function in hip OA participants and to evaluate various methods to measure changes in their physical functioning. Materials and Methods . 13 women aged ≥ 65 years with hip OA were recruited in this 12-week pilot study...
2017: Journal of Osteoporosis
Sarah E P Munce, Debra A Butt, Rokeni Sumi Anantharajah, Susana Huang, Sonya Allin, Tarik Bereket, Susan B Jaglal
Introduction. The purpose of this study is to understand the experience of primary care providers (PCPs) using an evidence-based requisition for bone mineral density (BMD) testing. Methods. A qualitative descriptive approach was adopted. Participants were given 3 BMD Recommended Use Requisitions (RUR) to use over a 2-month period. Twenty-six PCPs were interviewed before using the RUR. Those who had received at least one BMD report resulting from RUR use were then interviewed again. An inductive thematic analysis was performed...
2016: Journal of Osteoporosis
A E Bombak, H M Hanson
Purpose. Much of the research on osteoporosis has been generated quantitatively. However, the qualitative osteoporosis literature provides valuable information on patient and clinician experiences and perspectives, informing the design and implementation of health research and healthcare services. To identify knowledge gaps and inform the design of future qualitative research, a narrative review was conducted to consolidate and synthesize the existing insights available within the qualitative osteoporosis research...
2016: Journal of Osteoporosis
W Banks Hinshaw, Allyn F DeLong
The documented history of the development of the bisphosphonate drugs is reviewed in sufficient detail to permit independent evaluation of the consistency of the conclusions reached from the available data. The evidence developed during the early interval of these studies 1960-1975 was sufficient to establish that pyrophosphate shares the subsequently established dual bisphosphonate characteristics of bone resorption inhibition and prevention of tissue mineralization.
2016: Journal of Osteoporosis
Michael W J Davie, Sally F Evans, Christopher A Sharp
Aims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men. Methods. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular) and 2 diaphyseal (mainly cortical)). BMD at femoral neck (FN) and lumbar spine L2-4, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH), and urinary calcium and NTx/Cr, a measure of bone breakdown, were also measured...
2016: Journal of Osteoporosis
J Kelly Smith, Rhesa Dykes, David S Chi
Although it is recognized that the mechanical stresses associated with physical activity augment bone mineral density and improve bone quality, our understanding of how exercise modulates bone homeostasis at the molecular level is lacking. In a before and after trial involving 43 healthy adults, we measured the effect of six months of supervised exercise training on the spontaneous and phytohemagglutinin-induced production of osteoclastogenic cytokines (interleukin-1α, tumor necrosis factor-α), antiosteoclastogenic cytokines (transforming growth factor-β1 and interleukins 4 and 10), pleiotropic cytokines with variable effects on osteoclastogenesis (interferon-γ, interleukin-6), and T cell growth and differentiation factors (interleukins 2 and 12) by peripheral blood mononuclear cells...
2016: Journal of Osteoporosis
A Sánchez, L R Brun, H Salerni, P R Costanzo, D González, A Bagur, B Oliveri, M B Zanchetta, V Farías, L Maffei, V Premrou, J L Mansur, M S Larroudé, M A Sarli, P Rey, M R Ulla, M M Pavlove, S Karlsbrum, M L Brance
The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina. Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior...
2016: Journal of Osteoporosis
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