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Journal of Osteoporosis

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https://www.readbyqxmd.com/read/28913002/corrigendum-to-mikkeli-osteoporosis-index-identifies-fracture-risk-factors-and-osteoporosis-and-intervention-thresholds-parallel-with-frax
#1
Ville Juhana Waris, Joonas P Sirola, Vesa V Kiviniemi, Marjo T Tuppurainen, V Pekka Waris
[This corrects the article DOI: 10.4061/2011/732560.].
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28785507/corrigendum-to-predictors-of-fracture-risk-and-bone-mineral-density-in-men-with-prostate-cancer-on-androgen-deprivation-therapy
#2
Katherine Neubecker, Beverley Adams-Huet, Irfan M Farukhi, Rosinda Castanon, Ugis Gruntmanis
[This corrects the article DOI: 10.4061/2011/924595.].
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28638673/monitoring-of-cellular-changes-in-the-bone-marrow-following-pth-1-34-treatment-of-ovx-rats-using-a-portable-stray-field-nmr-scanner
#3
Inbar Hillel, Itzhak Binderman, Yifat Sarda, Uri Nevo
Osteoporosis is characterized by reduction in trabecular bone in conjunction with increased marrow cell adiposity. While these changes occur within weeks, monitoring of treatment efficacy as performed by DEXA is sensitive only to long-term changes. MRI is sensitive to bone marrow changes but is less affordable. In a recent study, we have shown that a stray-field NMR can monitor bone marrow cellular changes that are related to osteoporosis. Objectives. To demonstrate sensitivity of a low-field tabletop NMR scanner to bone marrow dynamics following hormonal treatment in rats...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28299231/chronic-osteoporotic-pain-in-mice-cutaneous-and-deep-musculoskeletal-pain-are-partially-independent-of-bone-resorption-and-differentially-sensitive-to-pharmacological-interventions
#4
Miyako Suzuki, Magali Millecamps, Lina Naso, Seiji Ohtori, Chisato Mori, Laura S Stone
Although the pathological changes in osteoporotic bones are well established, the characterization of the osteoporotic pain and its appropriate treatment are not fully elucidated. We investigated the behavioral signs of cutaneous and deep musculoskeletal pain and physical function; time-dependent changes in bone mineral density (BMD) and the emergence of the behavioral phenotype; and the effects of pharmacological interventions having different mechanisms of action (chronic intraperitoneal administration of pamidronate [0...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28168080/the-femoral-neck-mechanoresponse-to-hip-extensors-exercise-a-case-study
#5
Saulo Martelli, Hossein Mokhtarzadeh, Peter Pivonka, Peter R Ebeling
Physical activity is recommended to prevent age-related bone loss. However, the proximal femur mechanoresponse is variable, possibly because of a muscle-dependant mechanoresponse. We compared the proximal femur response with the femoral strain pattern generated by the hip extensor muscles. A healthy participant underwent a six-month unilateral training of the hip extensor muscles using a resistance weight regularly adjusted to the 80% of the one-repetition maximum weight. DXA-based measurements of the areal Bone Mineral Density (aBMD) in the exercise leg were adjusted for changes in the control leg...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28163951/a-review-on-the-relationship-between-aspirin-and-bone-health
#6
REVIEW
Kok-Yong Chin
Aspirin is a cyclooxygenase inhibitor commonly used in primary prevention of cardiovascular diseases and cancers. Its users are elderly population susceptible to osteoporosis. It also inhibits the synthesis of prostaglandin E2 essential in bone remodeling. This prompts the question whether it can influence bone health among users. This review aimed to summarize the current literature on the use of aspirin on bone health. A literature search on experimental and clinical evidence on the effects of aspirin on bone health was performed using major scientific databases...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28116214/exercise-training-in-treatment-and-rehabilitation-of-hip-osteoarthritis-a-12-week-pilot-trial
#7
Kirsti Uusi-Rasi, Radhika Patil, Saija Karinkanta, Kari Tokola, Pekka Kannus, Harri Sievänen
Introduction. Osteoarthritis (OA) of the hip is one of the major causes of pain and disability in the older population. Although exercise is an effective treatment for knee OA, there is lack of evidence regarding hip OA. The aim of this trial was to test the safety and feasibility of a specifically designed exercise program in relieving hip pain and improving function in hip OA participants and to evaluate various methods to measure changes in their physical functioning. Materials and Methods. 13 women aged ≥ 65 years with hip OA were recruited in this 12-week pilot study...
2017: Journal of Osteoporosis
https://www.readbyqxmd.com/read/28050306/acceptability-and-feasibility-of-an-evidence-based-requisition-for-bone-mineral-density-testing-in-clinical-practice
#8
Sarah E P Munce, Debra A Butt, Rokeni Sumi Anantharajah, Susana Huang, Sonya Allin, Tarik Bereket, Susan B Jaglal
Introduction. The purpose of this study is to understand the experience of primary care providers (PCPs) using an evidence-based requisition for bone mineral density (BMD) testing. Methods. A qualitative descriptive approach was adopted. Participants were given 3 BMD Recommended Use Requisitions (RUR) to use over a 2-month period. Twenty-six PCPs were interviewed before using the RUR. Those who had received at least one BMD report resulting from RUR use were then interviewed again. An inductive thematic analysis was performed...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27994908/qualitative-insights-from-the-osteoporosis-research-a-narrative-review-of-the-literature
#9
REVIEW
A E Bombak, H M Hanson
Purpose. Much of the research on osteoporosis has been generated quantitatively. However, the qualitative osteoporosis literature provides valuable information on patient and clinician experiences and perspectives, informing the design and implementation of health research and healthcare services. To identify knowledge gaps and inform the design of future qualitative research, a narrative review was conducted to consolidate and synthesize the existing insights available within the qualitative osteoporosis research...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27800209/an-evaluative-history-of-bisphosphonate-drugs-dual-physiologic-effects-of-pyrophosphate-as-inspiration-for-a-novel-pharmaceutical-class
#10
REVIEW
W Banks Hinshaw, Allyn F DeLong
The documented history of the development of the bisphosphonate drugs is reviewed in sufficient detail to permit independent evaluation of the consistency of the conclusions reached from the available data. The evidence developed during the early interval of these studies 1960-1975 was sufficient to establish that pyrophosphate shares the subsequently established dual bisphosphonate characteristics of bone resorption inhibition and prevention of tissue mineralization.
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27672477/lower-limb-metaphyseal-bone-is-lost-in-men-with-coeliac-disease-and-does-not-relate-to-parathyroid-status
#11
Michael W J Davie, Sally F Evans, Christopher A Sharp
Aims. To investigate regional lower limb bone density and associations with weight, PTH, and bone breakdown in coeliac men. Methods. From whole body DXA scans bone mineral density (BMD) was measured in 28 coeliac men, in the lower limb (subdivided into 6 regions, 3 being metaphyseal (mainly trabecular) and 2 diaphyseal (mainly cortical)). BMD at femoral neck (FN) and lumbar spine L2-4, body weight, height, serum calcium, alkaline phosphatase, parathyroid hormone (PTH), and urinary calcium and NTx/Cr, a measure of bone breakdown, were also measured...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27642534/the-effect-of-long-term-exercise-on-the-production-of-osteoclastogenic-and-antiosteoclastogenic-cytokines-by-peripheral-blood-mononuclear-cells-and-on-serum-markers-of-bone-metabolism
#12
J Kelly Smith, Rhesa Dykes, David S Chi
Although it is recognized that the mechanical stresses associated with physical activity augment bone mineral density and improve bone quality, our understanding of how exercise modulates bone homeostasis at the molecular level is lacking. In a before and after trial involving 43 healthy adults, we measured the effect of six months of supervised exercise training on the spontaneous and phytohemagglutinin-induced production of osteoclastogenic cytokines (interleukin-1α, tumor necrosis factor-α), antiosteoclastogenic cytokines (transforming growth factor-β1 and interleukins 4 and 10), pleiotropic cytokines with variable effects on osteoclastogenesis (interferon-γ, interleukin-6), and T cell growth and differentiation factors (interleukins 2 and 12) by peripheral blood mononuclear cells...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27579211/effect-of-denosumab-on-bone-mineral-density-and-markers-of-bone-turnover-among-postmenopausal-women-with-osteoporosis
#13
A Sánchez, L R Brun, H Salerni, P R Costanzo, D González, A Bagur, B Oliveri, M B Zanchetta, V Farías, L Maffei, V Premrou, J L Mansur, M S Larroudé, M A Sarli, P Rey, M R Ulla, M M Pavlove, S Karlsbrum, M L Brance
The aim of this study was to evaluate the effect of denosumab (Dmab) on bone mineral density (BMD) and bone turnover markers after 1 year of treatment. Additionally, the effect of Dmab in bisphosphonate-naïve patients (BP-naïve) compared to patients previously treated with bisphosphonates (BP-prior) was analyzed. This retrospective study included 425 postmenopausal women treated with Dmab for 1 year in clinical practice conditions in specialized centers from Argentina. Participants were also divided according to previous bisphosphonate treatment into BP-naïve and BP-prior...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27313945/sclerostin-antibody-therapy-for-the-treatment-of-osteoporosis-clinical-prospects-and-challenges
#14
REVIEW
Claire MacNabb, D Patton, J S Hayes
It is estimated that over 200 million adults worldwide have osteoporosis, a disease that has increasing socioeconomic impact reflected by unsustainable costs associated with disability, fracture management, hospital stays, and treatment. Existing therapeutic treatments for osteoporosis are associated with a variety of issues relating to use, clinical predictability, and health risks. Consequently, additional novel therapeutic targets are increasingly sought. A promising therapeutic candidate is sclerostin, a Wnt pathway antagonist and, as such, a negative regulator of bone formation...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27293954/association-of-trabecular-bone-score-with-inflammation-and-adiposity-in-patients-with-psoriasis-effect-of-adalimumab-therapy
#15
José L Hernández, Raquel López-Mejías, Ricardo Blanco, Trinitario Pina, Sheila Ruiz, Isabel Sierra, Begoña Ubilla, Verónica Mijares, Marcos A González-López, Susana Armesto, Alfonso Corrales, Enar Pons, Patricia Fuentevilla, Carmen González-Vela, Miguel Á González-Gay
Studies on trabecular bone score (TBS) in psoriasis are lacking. We aim to assess the association between TBS and inflammation, metabolic syndrome features, and serum adipokines in 29 nondiabetic patients with psoriasis without arthritis, before and after 6-month adalimumab therapy. For that purpose, adjusted partial correlations and stepwise multivariable linear regression analysis were performed. No correlation was found between TBS and disease severity. TBS was negatively associated with weight, BMI, waist perimeter, fat percentage, and systolic and diastolic blood pressure before and after adalimumab...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27239366/cross-calibration-of-ge-healthcare-lunar-prodigy-and-idxa-dual-energy-x-ray-densitometers-for-bone-mineral-measurements
#16
J Saarelainen, M Hakulinen, T Rikkonen, H Kröger, M Tuppurainen, H Koivumaa-Honkanen, R Honkanen, M Hujo, J S Jurvelin
In long-term prospective studies, dual-energy X-ray absorptiometry (DXA) devices need to be inevitably changed. It is essential to assess whether systematic differences will exist between measurements with the new and old device. A group of female volunteers (21-72 years) underwent anteroposterior lumbar spine L2-L4 (n = 72), proximal femur (n = 72), and total body (n = 62) measurements with the Prodigy and the iDXA scanners at the same visit. The bone mineral density (BMD) measurements with these two scanners showed a high linear association at all tested sites (r = 0...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27123357/bone-mineral-density-in-postmenopausal-women-heterozygous-for-the-c282y-hfe-mutation
#17
Jenny E Gunton, Frances Gates, Greg R Fulcher, Phillip B Clifton-Bligh
Mutations in the HFE gene may be associated with increased tissue iron stores reflected in an elevated serum ferritin. With homozygous mutation C282Y, the increase in serum ferritin may be associated with tissue damage in the liver, pancreas, and pituitary and with a reduced bone mineral density. With heterozygous mutation C282Y, the degree of iron retention is less but information relating to how a heterozygous C282Y mutation might impact bone mineral density is uncertain. The present study was undertaken to study the relationships between bone mineral density measured by dual energy X-ray absorptiometry and the serum ferritin and serum iron in postmenopausal women heterozygous for the C282Y mutation...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/27047700/bone-strength-and-arterial-stiffness-impact-on-cardiovascular-mortality-in-a-general-population
#18
Petar Avramovski, Maja Avramovska, Aleksandar Sikole
Osteoporosis and increased arterial stiffness independently have been found to be associated with higher cardiovascular events rates in the general population (GP). We examined 558 patients from GP by dual-energy X-ray absorptiometry (DXA) and pulse wave velocity (PWV) measurements at baseline, with 36-month follow-up period. DXA assessed bone mineral density of femoral neck (BMD FN) and lumbar spine (BMD LS). Carotid-femoral PWV was assessed by pulsed-Doppler. The aim of our study is to find correlation between bone strength and arterial stiffness and their impact on cardiovascular mortality in GP...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/26904357/understanding-referral-patterns-for-bone-mineral-density-testing-among-family-physicians-a-qualitative-descriptive-study
#19
Sarah E P Munce, Sonya Allin, Leslie Carlin, Joanna Sale, Gillian Hawker, Sandra Kim, Debra A Butt, Irene Polidoulis, Karen Tu, Susan B Jaglal
Introduction. Evidence of inappropriate bone mineral density (BMD) testing has been identified in terms of overtesting in low risk women and undertesting among patients at high risk. In light of these phenomena, the objective of this study was to understand the referral patterns for BMD testing among Ontario's family physicians (FPs). Methods. A qualitative descriptive approach was adopted. Twenty-two FPs took part in a semi-structured interview lasting approximately 30 minutes. An inductive thematic analysis was performed on the transcribed data in order to understand the referral patterns for BMD testing...
2016: Journal of Osteoporosis
https://www.readbyqxmd.com/read/26881176/the-effects-of-noncompliance-to-prolia-denosumab-on-the-changes-in-bone-mineral-density-a-retrospective-review
#20
Matthew Wong-Pack, Aashish Kalani, Jacob Hordyk, George Ioannidis, Robert Bensen, William G Bensen, Alexandra Papaioannou, Jonathan D Adachi, Arthur N Lau
Although denosumab (Prolia) has been shown to be a safe and efficacious therapy for osteoporotic patients in numerous clinical trials, few studies have determined its effectiveness in real world clinical practice. A retrospective review of patients prescribed Prolia assessing the impact that noncompliance from the regular dosing regimen of six months for denosumab has on bone mineral density (BMD) was performed. 924 patient records were reviewed between August 2012 and September 2013 with 436 patients meeting the eligibility criteria...
2016: Journal of Osteoporosis
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