journal
https://read.qxmd.com/read/38449420/alopecia-areata-review-of-epidemiology-pathophysiology-current-treatments-and-nanoparticulate-delivery-system
#21
REVIEW
Robel Singh, Pawan Kumar, Davinder Kumar, Navidha Aggarwal, Hitesh Chopra, Virender Kumar
Alopecia areata (AA) is a kind of alopecia that affects hair follicles and nails. It typically comes with round patches and is a type of nonscarring hair loss. Various therapies are accessible for the management and treatment of AA, including topical, systemic and injectable modalities. It is a very complex type of autoimmune disease and is identified as round patches of hair loss and may occur at any age. This review paper highlights the epidemiology, clinical features, pathogenesis and new treatment options for AA, with a specific emphasis on nanoparticulate drug-delivery systems...
March 2024: Therapeutic Delivery
https://read.qxmd.com/read/38124684/fabrication-of-dual-drug-loaded-polycaprolactone-gelatin-composite-nanofibers-for-full-thickness-diabetic-wound-healing
#22
JOURNAL ARTICLE
Manjit Manjit, Manish Kumar, Krishan Kumar, Madhukiran R Dhondale, Abhishek Jha, Kanchan Bharti, Zinnu Rain, Pradyot Prakash, Brahmeshwar Mishra
Aim: Design of moxifloxacin and ornidazole co-loaded polycaprolactone and gelatin nanofiber dressing for diabetic wounds. Materials & methods: The composite nanofibers were prepared using electrospinning technique and characterized for in vitro drug release, antibacterial activity, laser doppler and in vivo wound healing. Results: The optimized nanofiber demonstrated an interconnected bead free nanofiber with average diameter <200 nm. The in vitro drug release & antimicrobial studies revealed that optimized nanofiber provided drug release for >120 h, thereby inhibiting growth of Escherichia coli and Stapyhlococcus aureus ...
December 21, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38116620/engineered-exosomes-a-promising-vehicle-in-cancer-therapy
#23
REVIEW
Farkhondeh Pooresmaeil, Sahar Andi, Behnam Hasannejad-Asl, Shahla Takamoli, Azam Bolhassani
During the past few decades, researchers have attempted to discover an effective treatment for cancer. Exosomes are natural nanovesicles released by various cells and play a role in communication between cells. While natural exosomes have high clinical potential, their inherent limitations have prompted researchers to design exosomes with improved therapeutic properties. To achieve this purpose, researchers have undertaken exosome engineering to modify the surface properties or internal composition of exosomes...
December 20, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38116616/delivering-volume-15-welcome-to-another-year-of-therapeutic-delivery
#24
JOURNAL ARTICLE
Rebecca Turner
No abstract text is available yet for this article.
December 20, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38111996/nanoparticle-based-delivery-platforms-for-the-enhanced-oral-delivery-of-peptides-proteins
#25
REVIEW
Sara Salatin, Soheila Montazersaheb, Afsaneh Farjami, Samin Hamidi
Biopharmaceutical products are currently well-established in nearly all branches of medicine and are believed to have great potential for the treatment of a broad spectrum of diseases. Peptide/protein drugs exhibit a predominant class of new biopharmaceuticals coming on the market in recent years. Oral delivery of peptides/proteins as a non-invasive therapeutic technique has become an appealing alternative to the parenteral route. However, the efficient oral delivery of peptides/proteins is limited because of their high molecular weight, poor stability and low biodistribution...
December 19, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38088095/on-the-role-of-nanocarriers-in-oral-drug-delivery
#26
EDITORIAL
Qin Yu, Wei Wu
No abstract text is available yet for this article.
December 13, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38088094/a-narrative-review-on-naringin-and-naringenin-as-a-possible-bioenhancer-in-various-drug-delivery%C3%A2-formulations
#27
REVIEW
Pradeepti Ganesh, Vanishree Suresh, Manoj Kumar Narasimhan, Sarvesh Sabarathinam
Naringenin belongs to the flavanones and is mainly found in fruits (grapefruit and oranges) and vegetables. Naringenin exhibits lipid-lowering and insulin-like characteristics and is used to treat osteoporosis, cancer and cardiovascular disorders. Their incorporation into drug formulations offers several advantages, including enhanced solubility, improved bioavailability and targeted delivery. Naringin-based formulations are beneficial in cancer, for example controlling breast and prostate cancer by inhibition of CYP19...
December 13, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38084393/characteristics-and-release-of-isoniazid-from-inhalable-alginate-carrageenan-microspheres
#28
JOURNAL ARTICLE
Yotomi Desia Eka Rani, Mahardian Rahmadi, Dewi Melani Hariyadi
Aim: Inhalable microspheres made of polymers as a targeted drug delivery system have been developed to overcome the limitation of current treatments in Tuberculosis. Materials & methods: Isoniazid inhalable microspheres were created using a gelation ionotropic method with sodium alginate, carrageenan and calcium chloride in four different formulations. Result: The particle morphology has smooth surfaces and round spherical shapes with sizes below 5 μm; good flowability. The drug loading and entrapment efficiency values ranged from 1...
December 12, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38059311/september-industry-news-update
#29
JOURNAL ARTICLE
Fiona McCartney
No abstract text is available yet for this article.
December 7, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38054237/-in-situ-gastric-floating-gel-of-atazanavir-sulphate-for-sustained-release-formulation-optimization-and-evaluation
#30
JOURNAL ARTICLE
Rajashree Masareddy, Pradnya Sandure, Archana Patil, Yadishma Gaude, Arpana Patil
Aim: Atazanavir sulphate belongs to BCS class II drug, its oral bioavailability is limited due to its rapid first-pass metabolism and P-gp efflux. Materials & methods: The in situ floating gel using the complexed drug was prepared by ion gelation method and optimized the formulation as per 32 full factorial design. Results: Floating lag time of optimized formulation was found to be 18 s and percentage drug release of 94.18 ± 0.18 % at the end of 16 h. The concentration of gelling polymer affects drug release and a floating lag time and vice versa ...
December 6, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38018449/anthocyanin-enriched-extract-from-ribes-nigrum-inhibits-triglyceride-and-cholesterol-accumulation-in-adipocytes
#31
JOURNAL ARTICLE
Laura Montaldo, Alicia Gallo, Gabriela Rocha, Cecilia Csernoch, Mauricio De Marzi, Liliana N Guerra
Aim: Obesity is a chronic pathology of epidemic proportions. Mature adipocytes from a 3T3-L1 cell line were used as in vitro obesity model to test different bioactive compounds. We aim to evaluate cassis ( Ribes nigrum ) extract antioxidant activity and its antiadipogenic effect on mature adipocytes. Results: We produced an extract by using enzyme that combines cellulase and pectinase; we obtained high yield of the bioactive compound anthocyanin. Extract showed high antioxidant capacity. We conducted in vitro assays by adding the extract to adipocytes culture medium...
November 29, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38018431/quality-by-design-assisted-development-of-d-%C3%AE-tocopherol-polyethylene-glycol-1000-succinate-incorporated-gefitinib-loaded-cationic-liposome-s
#32
JOURNAL ARTICLE
Lopamudra Mishra, Shuvadip Bhowmik, Rajveer Singh, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi
Aim: Gefitinib-loaded D-α-tocopherol polyethylene glycol 1000 succinate (TPGS)-coated cationic liposomes (GEF-TPGS-LIPO+ ) were developed and optimized by the quality by design (QbD) approach for its potential anticancer effect. Methods/materials: Box-Behnken design (BBD) a systematic design of experiments was added to screen and optimize the formulation variables. Results: GEF-TPGS-LIPO+ shows vesicle size (210 ± 4.82 nm), polydispersity index (0.271 ± 0.002), zeta potential (22...
November 29, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38014488/propranolol-hcl-loaded-liposomes-for-intranasal-delivery-in-vitro-and-ex-vivo-evaluation-of-optimized-formulation-using-design-of-experiments
#33
JOURNAL ARTICLE
Vishal Kumar, Nethish Kumaar R, D Aswin, Sreeja C Nair
Aim: To develop a propranolol HCL-loaded liposomal nasal formulation for migraine prophylaxis. Materials & methods: Formulated the liposomes through thin layer hydration method and optimized via design of experiments (DOE). The prepared liposomes were characterized for particle size, zeta potential, PDI, drug entrapment and drug loading. Assessed for in vitro release kinetics, ex vivo permeability, histopathology and stability. Results: Optimized liposomes: 135.52 ± 5...
November 28, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38014467/the-potential-of-dna-nanotechnology-to-advance-multiple-therapeutic-systems
#34
EDITORIAL
Igor L Medintz, Divita Mathur
No abstract text is available yet for this article.
November 28, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38014434/role-of-inorganic-ions-in-wound-healing-an-insight-into-the-various-approaches-for-localized-delivery
#35
REVIEW
M C Linju, M R Rekha
Recently, the role of inorganic ions has been explored for its wound-healing applications. Ions do play key role in the normal functioning of the skin, including the epidermal barrier property, maintaining redox balance, enzymatic activities, tissue remodeling, etc. The care of chronic wounds is a concern and new cost-effective therapeutic strategies that modulate the wound microenvironment and cell behaviour are needed. First, this review illustrates the ions that play a role in wound healing and their molecular mechanisms that are accountable for modifying the wound...
November 28, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38014430/microemulsions-nanoemulsions-and-emulgels-as-carriers-for-antifungal-antibiotics
#36
REVIEW
Annapurna Padaraju, Falguni Dwivedi, Gautam Kumar
According to estimates, up to 25% of the world's population has fungal skin diseases, making them the most prevalent infectious disease. Several chemical classes of antifungal drugs are available to treat fungal infections. However, the major challenges of conventional formulations of antifungal drugs include poor pharmacokinetic profiles like solubility, low permeability, side effects and decreased efficacy. Novel drug delivery is a promising approach for overcoming pharmacokinetic limitations and increasing the effectiveness of antibiotics...
November 28, 2023: Therapeutic Delivery
https://read.qxmd.com/read/37877308/internal-stimuli-responsive-nanocarriers-for-controlled-anti-cancer-drug-release-a-review
#37
REVIEW
Baji Baba Shaik, Naresh Kumar Katari, Sreekanth B Jonnalagadda
Cancer disease is one of the most frequent life-threatening, with a high fatality rate worldwide. However, recent immunotherapy studies in various tumours have yielded unsatisfactory outcomes, with just a few individuals experiencing long-term responses. To overcome these issues, nowadays internal stimuli-responsive nanocarriers have been widely exploited to transport a wide range of active substances, including peptides, genes and medicines. These nanosystems could be chemically adjusted to produce target-based drug release at the target location, minimizing pathological and physiological difficulties while increasing therapeutic efficiency...
October 25, 2023: Therapeutic Delivery
https://read.qxmd.com/read/37786969/industry-update-the-latest-developments-in-the-field-of-therapeutic-delivery-july-2023
#38
JOURNAL ARTICLE
Peter Timmins
No abstract text is available yet for this article.
October 3, 2023: Therapeutic Delivery
https://read.qxmd.com/read/38050965/formulation-optimization-and-evaluation-of-amisulpride-loaded-niosomal-intranasal-gel-for-brain-targeting
#39
JOURNAL ARTICLE
Vinayak S Patil, Kishori P Sutar, Rachana D Pockle, Siddarth Usulkar, Vishwanath A Jadhav
Aim: To develop stable non-ionic surfactant vesicles containing amisulpride (AMS) to improve brain uptake via nose to brain mechanism. Methods: Niosomes were developed using a modified ethanol injection technique, optimized using 32 factorial design and evaluated for the vesicle size (VS), percent encapsulation efficiency (EE), zeta potential (ZP) and % cumulative drug release (%CDR). Results: Optimized niosomes (Span-60: cholesterol ratio 0:1) showed 191.4 nm VS, 84.25% EE, -38.2 ZP and 81.31% CDR...
October 2023: Therapeutic Delivery
https://read.qxmd.com/read/37691579/can-amphotericin-b-mediated-effects-be-limited-using-intranasal-versus-intravenous-route
#40
JOURNAL ARTICLE
Ruqaiyyah Siddiqui, Timothy Yu Yee Ong, Sutherland Maciver, Naveed Ahmed Khan
Aim: CNS infections due to parasites often prove fatal. In part, this is due to inefficacy of drugs to cross the blood-brain barrier. Methods: Here, we tested intranasal and intravenous route and compared adverse effects of Amphotericin B administration, through blood biochemistry, liver, kidney and brain histopathological evidence of toxicities in vivo post-administration. Results: It was observed that intranasal route limits the adverse side effects of Amphotericin B, in contrast to intravenous route. Conclusion: As parasites such as Naegleria fowleri exhibit unequivocal affinity toward the olfactory bulb and frontal lobe in the central nervous system, intranasal administration would directly reach amoebae bypassing the blood-brain barrier selectivity and achieve the minimum inhibitory concentration at the target site...
September 11, 2023: Therapeutic Delivery
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