journal
MENU ▼
Read by QxMD icon Read
search

Therapeutic Delivery

journal
https://www.readbyqxmd.com/read/28747100/loading-and-elution-characteristics-of-quadrasphere-microspheres-loaded-with-bevacizumab
#1
Martin Oselkin, Neda I Sedora-Roman, Bryan A Pukenas, David Kung, Robert W Hurst
AIM: Super absorbent polyvinyl alcohol-sodium acrylate copolymer microspheres, Quadrasphere microspheres (QSM), are commonly used for drug-eluting bead therapy, however, the literature only reports its use with small molecule chemotherapeutics. This study evaluates the loading and elution characteristics of bevacizumab-loaded QSM. METHODS & RESULTS: A single vial of QSM was reconstituted with 200 mg of bevacizumab. Drug concentration was determined by ELISA immunoassay...
July 27, 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28659016/calcipotriene-betamethasone-dipropionate-aerosol-foam-in-the-treatment-of-plaque-psoriasis-a-review-of-the-literature
#2
Jillian Frieder, Dario Kivelevitch, Alan Menter
Psoriasis is a common chronic immune-mediated skin disease which has a significant impact on patients' quality of life, and is associated with numerous comorbidities (i.e., psoriatic arthritis, Crohn's disease and cardiovascular disease). A greater understanding of its immunopathogenesis has guided the development of novel, more targeted therapies. Nonetheless, traditional treatment with topical agents, phototherapy and systemic medications is used in the management of the majority of psoriasis patients. Mainstay topical treatments include corticosteroids and vitamin D derivatives...
June 29, 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730942/posterior-drug-delivery-via-periocular-route-challenges-and-opportunities
#3
David Waite, Yujing Wang, David Jones, Alan Stitt, Thakur Raghu Raj Singh
Drug delivery to the posterior segment via the periocular route is a promising route for delivery of a range of formulations. In this review, we have highlighted the challenges and opportunities of posterior segment drug delivery via the periocular route. Consequently, we have discussed different types of periocular routes, physiological barriers that limit effective drug delivery, practical challenges regarding patient compliance and acceptability and recent advances in developing innovative strategies to enhance periocular drug delivery...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730941/how-can-we-fine-tune-nanoparticles-to-improve-drug-delivery
#4
Zibiao Li
No abstract text is available yet for this article.
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730940/nanomicrobicides-for-hiv-vaginal-transmission-prevention-where-do-we-stand
#5
Vivek Agrahari
No abstract text is available yet for this article.
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730939/drug-delivery-to-the-brain-how-can-nanoencapsulated-statins-be-used-in-the-clinic
#6
Fabio Sonvico, Francesca Zimetti, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres
Statins are used for the primary and secondary prevention of cardiovascular disease by inhibiting cholesterol synthesis in the liver. Statins have also noncholesterol-related effects, called pleiotropic effects, which arise from statins' anti-inflammatory, immunomodulatory and antioxidant properties. These effects are especially attractive for the treatment of various brain diseases ranging from stroke to neurodegenerative diseases. Still, low brain concentrations after oral drug administration hinder the clinical application of statins in these pathologies...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730938/stratum-corneum-modulation-by-chemical-enhancers-and-lipid-nanostructures-implications-for-transdermal-drug-delivery
#7
Mudra Saurabh Kapoor, Shruti GuhaSarkar, Rinti Banerjee
Skin is the outermost and largest protective covering of the body. The uppermost layer of the skin, stratum corneum also called the horny layer is composed of keratin-filled cells covered by a lipid matrix which shields the skin from physical and chemical entrants. The lipid lamellar structure comprises of ceramides, cholesterol, fatty acids and proteins. Chemical enhancers that mimic the lamellar chemistry, reversibly fluidize the latter can be utilized for enhancing transport of cargo across the epidermis into the dermis...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730937/clay-based-drug-delivery-systems-what-does-the-future-hold
#8
Giuseppe, Serena Riela, Rawil F Fakhrullin
Clays for drug delivery have been used from ancient time due to the large availability of clay minerals and their unprecedented properties. The empirical use of nanoclays from the past is converted in a stimulating scientific task aimed at building up nanoarchitectonic vehicles for drug delivery in a targeted and stimuli-responsive fashion. Here the historical aspects are discussed; next the modern examples of applications of different clay-based materials are discussed. A special focus is given to halloysite clay nanotubes, which are an emerging and very promising nanomaterial for drug-delivery purposes due to its special morphology and unique chemical properties...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730936/an-industry-update-what-is-the-latest-news-in-therapeutic-delivery
#9
Iain Simpson
This Industry Update covers the period from 1 through 30 April 2017, and is based on information sourced from company press releases, scientific literature, patents and various news websites. Biogen expanded its portfolio of developmental drugs targeting neurological diseases by licensing a drug from Bristol-Myers Squibb which is currently under investigation for the treatment of progressive supranuclear palsy. Takeda announced a deal with NuBiyota focused on developing treatments for gastrointestinal disorders, based on the manipulation of microbes living in the gut...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730935/effect-of-directly-compressible-excipient-and-treated-agar-on-drug-release-of-clopidogrel-oral-disintegrating-tablets
#10
Kambham Venkateswarlu, Manyam Nirosha, Budideti Kishore Kumar Reddy, Badithala Siva Sai Kiran
AIM: In the present investigation, oral dissolving/dispersible/disintegrating tablets (ODTs) of clopidogrel were designed with a view to enhance the bioavailability and patient compliance by two different methods, namely, direct compression and effervescent methods using directly compressible excipient and treated agar (TAG). MATERIALS & METHODS: In the direct compression method, TAG was used as a disintegrant and another method used a mixture of sodium bicarbonate and tartaric acid along with TAG as disintegrants...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730934/challenges-in-oral-peptide-delivery-lessons-learnt-from-the-clinic-and-future-prospects
#11
Joël Richard
Therapeutic peptides have become very successful drugs due to their specificity, potency and low toxicity, but they show challenges for their delivery, due to their short half-life and rapid plasma clearance. For these reasons, peptides are usually administered using injectable sustained-release formulations. Oral peptide route is highly compelling from a patient and commercial point of view. However, poor peptide stability and low permeability across the intestinal epithelium still make it very challenging to effectively deliver peptides by the oral route...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28730933/drug-delivery-to-the-lungs-challenges-and-opportunities
#12
Stephen P Newman
Pulmonary drug delivery is relatively complex because the respiratory tract has evolved defense mechanisms to keep inhaled drug particles out of the lungs and to remove or inactivate them once deposited. In addition to these mechanical, chemical and immunological barriers, pulmonary drug delivery is adversely affected by the behavioral barriers of poor adherence and poor inhaler technique. Strategies to mitigate the effects of these barriers include use of inhaler devices and formulations that deliver drug to the lungs efficiently, appropriate inhaler technique and improved education of patients...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633594/targeting-and-delivery-of-therapeutic-enzymes
#13
Scott N Dean, Kendrick B Turner, Igor L Medintz, Scott A Walper
Biotechnology has revolutionized therapeutics for the treatment of a wide range of diseases. Recent advances in protein engineering and material science have made the targeted delivery of enzyme therapeutics using nanocarriers (NCs) a new model of treatment. Several NCs have been approved for clinical use in drug delivery. Despite their advantages, few NCs have been approved to deliver enzyme cargo in a targeted manner. This review details the current arsenal of platforms developed to deliver enzyme therapeutics as well as the advantages and challenges of using enzymes as drugs, with examples from the literature, and discusses the benefits and liabilities of a given approach...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633593/an-industry-update-the-latest-developments-in-the-field-of-therapeutic-delivery
#14
Peter Timmins
No abstract text is available yet for this article.
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633592/recent-advances-in-therapeutic-delivery-systems-of-bacteriophage-and-bacteriophage-encoded-endolysins
#15
Hollie Hathaway, Scarlet Milo, J Mark Sutton, Toby A Jenkins
Antibiotics have been the cornerstone of clinical management of bacterial infection since their discovery in the early 20th century. However, their widespread and often indiscriminate use has now led to reports of multidrug resistance becoming globally commonplace. Bacteriophage therapy has undergone a recent revival in battle against pathogenic bacteria, as the self-replicating and co-evolutionary features of these predatory virions offer several advantages over conventional therapeutic agents. In particular, the use of targeted bacteriophage therapy from specialized delivery platforms has shown particular promise owing to the control of delivery location, administration conditions and dosage of the therapeutic cargo...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633591/approaches-in-topical-ocular-drug-delivery-and-developments-in-the-use-of-contact-lenses-as-drug-delivery-devices
#16
Prina Mehta, Rita Haj-Ahmad, Ali Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633590/polymeric-therapeutic-delivery-systems-for-the-treatment-of-infectious-diseases
#17
Blessing A Aderibigbe
Infectious diseases caused by germs, parasites, fungi, virus and bacteria are one of the leading causes of death worldwide. Polymeric therapeutics are nanomedicines that offer several advantages making them useful for the treatment of infectious diseases such as targeted drug release mechanism, ability to maintain the drug concentration within a therapeutic window for a desired duration, biocompatibility with low immunogenicity and reduced drug toxicity resulting in enhanced therapeutic efficacy of the incorporated drug...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633589/laser-induced-thermal-ablation-of-cancerous-cell-organelles
#18
Renat R Letfullin, Scott A Szatkowski
AIM: By exploiting the physical changes experienced by cancerous organelles, we investigate the feasibility of destroying cancerous cells by single and multipulse modes of laser heating. MATERIALS & METHODS: Our procedure consists of two primary steps: determining the normal and cancerous organelles optical properties and simulating the heating of all of the major organelles in the cell to find the treatment modes for the laser ablation of cancerous organelles without harming healthy cells...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633588/new-strategies-for-cancer-management-how-can-temozolomide-carrier-modifications-improve-its-delivery
#19
Saurabh Sharma, Kishan Italiya, Anupama Mittal, Deepak Chitkara
No abstract text is available yet for this article.
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28555530/albumin-based-drug-delivery-using-cysteine-34-chemical-conjugates-important-considerations-and-requirements
#20
Mikael B Caspersen, Matthias Kuhlmann, Karl Nicholls, Malcolm J Saxton, Birgitte Andersen, Karen Bunting, Jason Cameron, Kenneth A Howard
The long blood circulation time of albumin has been clinically utilized as a half-life extension technology for improved drug performance. The availability of one free thiol for site-selective chemical conjugation offers an alternative approach to current genetic fusion and association-based products. This special report highlights important factors for successful conjugation that allows the reader to design and evaluate next-generation albumin conjugates. Albumin type, available conjugation chemistries, linker length, animal models and influence of conjugation on albumin pharmacokinetics and drug activity are discussed...
July 2017: Therapeutic Delivery
journal
journal
43215
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"