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Therapeutic Delivery

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https://www.readbyqxmd.com/read/28470113/nebulized-drug-delivery-in-respiratory-medicine-what-does-the-future-hold
#1
John N Pritchard
In the later half of the 20th century, nebulized therapy was in decline, but in the 21st century the prospects for the expanded use of nebulized therapy within respiratory medicine look bright. The advent of mesh nebulizers, which combine the universal applicability of the nebulizer in the treatment of all respiratory patients with the convenience of portable inhaler use, is ideally timed to capitalize on the forecast of increased numbers of patients who will require nebulized therapy in the future. This special report will highlight some of the opportunities that the development of mesh nebulizers presents in the field of respiratory medicine...
May 4, 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28350230/predicting-in-vivo-behavior-of-injectable-in-situ-forming-drug-delivery-systems
#2
Christopher Hernandez, Agata A Exner
No abstract text is available yet for this article.
March 28, 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28287026/erratum
#3
(no author information available yet)
No abstract text is available yet for this article.
March 13, 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530151/microneedles-for-vaccine-delivery-challenges-and-future-perspectives
#4
Chong In Shin, Seong Dong Jeong, N Sanoj Rejinold, Yeu-Chun Kim
Vaccine delivery to the skin using conventional needles is associated with needle-stick injuries and needle-phobia, which are all major obstacles to vaccination. The development of microneedles has enabled to overcome these limitations and as a result viral, DNA and bacterial vaccines have been studied for the delivery into the skin. Research has shown the superiority of microneedle vaccination over conventional needles in terms of immunogenicity, vaccine stability and dose-sparing abilities in animals and humans...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530150/the-roles-of-bile-acids-and-applications-of-microencapsulation-technology-in-treating-type-1-diabetes-mellitus
#5
Louise Woodhams, Hani Al-Salami
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the loss of glycemic control. Recent studies have shown significant inflammation and disturbed bile acid homeostasis, associated with T1DM. Bile acids are endogenously produced as a result of cholesterol catabolism in the liver and solely metabolized by gut microflora. This review investigates their potential oral delivery in T1DM using targeted delivery and encapsulation technologies. A sensitive and selective search was carried out using different search engines and databases...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530149/a-technology-roadmap-of-smart-biosensors-from-conventional-glucose-monitoring-systems
#6
Pravin Shende, Pratiksha Sahu, Ram Gaud
The objective of this review article is to focus on technology roadmap of smart biosensors from a conventional glucose monitoring system. The estimation of glucose with commercially available devices involves analysis of blood samples that are obtained by pricking finger or extracting blood from the forearm. Since pain and discomfort are associated with invasive methods, the non-invasive measurement techniques have been investigated. The non-invasive methods show advantages like non-exposure to sharp objects such as needles and syringes, due to which there is an increase in testing frequency, improved control of glucose concentration and absence of pain and biohazard materials...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530148/an-industry-update-what-is-new-in-the-field-of-therapeutic-delivery-this-month
#7
Elaine Harris
The present industry update covers the period 1-28 February 2017. Information was sourced primarily from company press releases, regulatory and patent agencies, scientific literature and various news websites. A report issued this month indicated that the recent American election has influenced the rate and volume of pharma acquisitions and mergers (A&M) in the final quarter of 2016 and it remains to be seen what (if any) is the effect on the therapeutic drug delivery sector in the longer term. There was positive approval news this month for Valeant, Intellipharmaceutics and Pfizer for products that offered novel therapeutic delivery...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530147/exposing-the-tumor-microenvironment-how-gold-nanoparticles-enhance-and-refine-drug-delivery
#8
Lawrence Tamarkin, David G I Kingston
No abstract text is available yet for this article.
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530146/an-emerging-integration-between-ionic-liquids-and-nanotechnology-general-uses-and-future-prospects-in-drug-delivery
#9
Tânia Santos de Almeida, Ana Júlio, Joana Portugal Mota, Patrícia Rijo, Catarina Pinto Reis
There is a growing need to develop drug-delivery systems that overcome drawbacks such as poor drug solubility/loading/release, systemic side effects and limited stability. Ionic liquids (ILs) offer many advantages and their tailoring represents a valuable tuning tool. Nano-based systems are also prized materials that prevent drug degradation, enhance their transport/distribution and extend their release. Consequently, structures containing ILs and nanoparticles (NPs) have been developed to attain synergistic effects...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530145/bioengineered-liposome-scaffold-composites-as-therapeutic-delivery-systems
#10
Claudia Zylberberg, Sandro Matosevic
The therapeutic potential of liposomes can be amplified when combined with biomaterial scaffolds. Such configurations overcome the convergent demands of therapies by enabling enhanced delivery, environmental responsiveness and potency. Liposomes benefit from the increased physical and mechanical strength, favorable rheological properties and natural environment conducive to improved tissue formation that scaffolds provide, while enabling biocompatible delivery of hydrophilic and lipophilic compounds that can be further functionalized to achieve targeted delivery...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530144/disulfide-conjugation-chemistry-a-mixed-blessing-for-therapeutic-drug-delivery
#11
Maarten Danial, Almar Postma
No abstract text is available yet for this article.
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530143/intranasal-melatonin-nanoniosomes-pharmacokinetic-pharmacodynamics-and-toxicity-studies
#12
Aroonsri Priprem, Jeffrey R Johns, Sucharat Limsitthichaikoon, Wanwisa Limphirat, Pramote Mahakunakorn, Nutjaree Prateepawanit Johns
AIM: Intranasal melatonin encapsulated in nanosized niosomes was preclinically evaluated. METHODOLOGY: A formula of melatonin niosomes (MN) was selected through physicochemical and cytotoxic data for pharmacokinetic, pharmacodynamics and toxicity studies in male Wistar rats. RESULTS: Intranasal MN was bioequivalent to intravenous injection of melatonin, providing therapeutic level doses. Acute and subchronic toxicity screening showed no abnormal signs, symptoms or hematological effects in any animals...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28222661/an-industry-update-what-are-the-latest-developments-in-the-field-of-therapeutic-delivery-industry-update-1st-december-to-31st-december-2016
#13
Peter Timmins
No abstract text is available yet for this article.
April 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28222660/potential-therapeutic-application-of-dendrimer-cyclodextrin-conjugates-with-targeting-ligands-as-advanced-carriers-for-gene-and-oligonucleotide-drugs
#14
Hidetoshi Arima, Keiichi Motoyama, Taishi Higashi
Despite the recent approval of some gene medicines and nucleic acid drugs, further improvement of delivery techniques for these drugs is strongly required. Several delivery technologies for these drugs have been developed, in other words, viral and two types of nonviral (lipofection and polyfection) vectors. Among the polyfection system, the potential use of various cyclodextrin (CyD) derivatives and CyD-appended polymers as carriers for gene and nucleic acid drugs has been demonstrated. The polyamidoamine dendrimer (G3) conjugates with α-CyD (α-CDE (G3)) have been reported to possess noteworthy properties as DNA and nucleic acid drugs carriers...
April 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28222659/antimalarial-solid-self-emulsifying-system-for-oral-use-in-vitro-investigation
#15
Sameer Bhandari, Vikas Rana, Ashok K Tiwary
AIM: The low aqueous solubility of artemether and lumefantrine makes them less bioavailable. It is expected that by formulating self-microemulsifying drug-delivery systems (SMEDDS), their aqueous solubility and absorption will thus be enhanced. Results & methodology: Optimized liquid SMEDDS containing artemether and lumefantrine was adsorbed on Neusilin US2(®) employing spray drying technique to convert it into solid SMEDDS. Almost 90% of both drugs were released within 15 min in their respective official dissolution media...
April 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28222658/how-can-nano-delivery-systems-selectively-kill-cancerous-cells
#16
Maria-Eleni Kyriazi, Amelie Heuer-Jungemann, Antonios G Kanaras
No abstract text is available yet for this article.
April 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28222657/inner-ear-targeted-drug-delivery-what-does-the-future-hold
#17
Vibhuti Agrahari, Vivek Agrahari, Ashim K Mitra
No abstract text is available yet for this article.
April 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28361614/therapeutic-approaches-for-the-delivery-of-tnf-%C3%AE-sirna
#18
Palpandi Pandi, Anjali Jain, Saka Raju, Wahid Khan
Immune-mediated diseases are emerging as a major healthcare concern in the present era. TNF-α, a proinflammatory cytokine, plays a major role in the manifestation of these diseases by mediating different pathways and inducing the expression of other cytokines. In last decades, monoclonal antibodies and extracellular portion of human TNF-α receptors are explored in this area; however, the risk of immunological response and undesired effects urge a need to develop more effective therapies to control TNF-α levels...
March 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28361613/synergistic-efficacy-of-ultrasound-sonosensitizers-and-chemotherapy-a-review
#19
Henry Hirschberg, Steen J Madsen
Chemotherapeutic agents, either in the form of systemically injected free drug or encapsulated in nanoparticles transport vehicles, must overcome three main obstacles prior to reaching and interacting with their intended target inside tumor cells. Drugs must leave the circulation, overcome the tissue-tumor barrier and penetrate the cell's plasma membrane. Since, many agents enter the cell by endocytosis, they must avoid entrapment and degradation by the intracellular endolysosome complex. Ultrasound has demonstrated potential to enhance the efficacy of chemotherapy by reducing these barriers...
March 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28361612/targeting-therapeutics-to-the-plasma-membrane-opportunities-for-nanoparticle-mediated-delivery-abound
#20
Kelly E Burns, James B Delehanty
No abstract text is available yet for this article.
March 2017: Therapeutic Delivery
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