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Therapeutic Delivery

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https://www.readbyqxmd.com/read/28633594/targeting-and-delivery-of-therapeutic-enzymes
#1
Scott N Dean, Kendrick B Turner, Igor L Medintz, Scott A Walper
Biotechnology has revolutionized therapeutics for the treatment of a wide range of diseases. Recent advances in protein engineering and material science have made the targeted delivery of enzyme therapeutics using nanocarriers (NCs) a new model of treatment. Several NCs have been approved for clinical use in drug delivery. Despite their advantages, few NCs have been approved to deliver enzyme cargo in a targeted manner. This review details the current arsenal of platforms developed to deliver enzyme therapeutics as well as the advantages and challenges of using enzymes as drugs, with examples from the literature, and discusses the benefits and liabilities of a given approach...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633593/an-industry-update-the-latest-developments-in-the-field-of-therapeutic-delivery
#2
Peter Timmins
No abstract text is available yet for this article.
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633592/recent-advances-in-therapeutic-delivery-systems-of-bacteriophage-and-bacteriophage-encoded-endolysins
#3
Hollie Hathaway, Scarlet Milo, J Mark Sutton, Toby A Jenkins
Antibiotics have been the cornerstone of clinical management of bacterial infection since their discovery in the early 20th century. However, their widespread and often indiscriminate use has now led to reports of multidrug resistance becoming globally commonplace. Bacteriophage therapy has undergone a recent revival in battle against pathogenic bacteria, as the self-replicating and co-evolutionary features of these predatory virions offer several advantages over conventional therapeutic agents. In particular, the use of targeted bacteriophage therapy from specialized delivery platforms has shown particular promise owing to the control of delivery location, administration conditions and dosage of the therapeutic cargo...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633591/approaches-in-topical-ocular-drug-delivery-and-developments-in-the-use-of-contact-lenses-as-drug-delivery-devices
#4
Prina Mehta, Rita Haj-Ahmad, Ali Al-Kinani, Muhammad Sohail Arshad, Ming-Wei Chang, Raid G Alany, Zeeshan Ahmad
Drug-delivery approaches have diversified over the last two decades with the emergence of nanotechnologies, smart polymeric systems and multimodal functionalities. The intended target for specific treatment of disease is the key defining developing parameter. One such area which has undergone significant advancements relates to ocular delivery. This has been expedited by the development of material advancement, mechanistic concepts and through the deployment of advanced process technologies. This review will focus on the developments within lens-based drug delivery while touching on conventional and current methods of topical ocular drug delivery...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633590/polymeric-therapeutic-delivery-systems-for-the-treatment-of-infectious-diseases
#5
Blessing A Aderibigbe
Infectious diseases caused by germs, parasites, fungi, virus and bacteria are one of the leading causes of death worldwide. Polymeric therapeutics are nanomedicines that offer several advantages making them useful for the treatment of infectious diseases such as targeted drug release mechanism, ability to maintain the drug concentration within a therapeutic window for a desired duration, biocompatibility with low immunogenicity and reduced drug toxicity resulting in enhanced therapeutic efficacy of the incorporated drug...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633589/laser-induced-thermal-ablation-of-cancerous-cell-organelles
#6
Renat R Letfullin, Scott A Szatkowski
AIM: By exploiting the physical changes experienced by cancerous organelles, we investigate the feasibility of destroying cancerous cells by single and multipulse modes of laser heating. MATERIALS & METHODS: Our procedure consists of two primary steps: determining the normal and cancerous organelles optical properties and simulating the heating of all of the major organelles in the cell to find the treatment modes for the laser ablation of cancerous organelles without harming healthy cells...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28633588/new-strategies-for-cancer-management-how-can-temozolomide-carrier-modifications-improve-its-delivery
#7
Saurabh Sharma, Kishan Italiya, Anupama Mittal, Deepak Chitkara
No abstract text is available yet for this article.
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28555530/albumin-based-drug-delivery-using-cysteine-34-chemical-conjugates-important-considerations-and-requirements
#8
Mikael B Caspersen, Matthias Kuhlmann, Karl Nicholls, Malcolm J Saxton, Birgitte Andersen, Karen Bunting, Jason Cameron, Kenneth A Howard
The long blood circulation time of albumin has been clinically utilized as a half-life extension technology for improved drug performance. The availability of one free thiol for site-selective chemical conjugation offers an alternative approach to current genetic fusion and association-based products. This special report highlights important factors for successful conjugation that allows the reader to design and evaluate next-generation albumin conjugates. Albumin type, available conjugation chemistries, linker length, animal models and influence of conjugation on albumin pharmacokinetics and drug activity are discussed...
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28350230/predicting-in-vivo-behavior-of-injectable-in-situ-forming-drug-delivery-systems
#9
Christopher Hernandez, Agata A Exner
No abstract text is available yet for this article.
July 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530151/microneedles-for-vaccine-delivery-challenges-and-future-perspectives
#10
Chong In Shin, Seong Dong Jeong, N Sanoj Rejinold, Yeu-Chun Kim
Vaccine delivery to the skin using conventional needles is associated with needle-stick injuries and needle-phobia, which are all major obstacles to vaccination. The development of microneedles has enabled to overcome these limitations and as a result viral, DNA and bacterial vaccines have been studied for the delivery into the skin. Research has shown the superiority of microneedle vaccination over conventional needles in terms of immunogenicity, vaccine stability and dose-sparing abilities in animals and humans...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530150/the-roles-of-bile-acids-and-applications-of-microencapsulation-technology-in-treating-type-1-diabetes-mellitus
#11
Louise Woodhams, Hani Al-Salami
Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the loss of glycemic control. Recent studies have shown significant inflammation and disturbed bile acid homeostasis, associated with T1DM. Bile acids are endogenously produced as a result of cholesterol catabolism in the liver and solely metabolized by gut microflora. This review investigates their potential oral delivery in T1DM using targeted delivery and encapsulation technologies. A sensitive and selective search was carried out using different search engines and databases...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530149/a-technology-roadmap-of-smart-biosensors-from-conventional-glucose-monitoring-systems
#12
Pravin Shende, Pratiksha Sahu, Ram Gaud
The objective of this review article is to focus on technology roadmap of smart biosensors from a conventional glucose monitoring system. The estimation of glucose with commercially available devices involves analysis of blood samples that are obtained by pricking finger or extracting blood from the forearm. Since pain and discomfort are associated with invasive methods, the non-invasive measurement techniques have been investigated. The non-invasive methods show advantages like non-exposure to sharp objects such as needles and syringes, due to which there is an increase in testing frequency, improved control of glucose concentration and absence of pain and biohazard materials...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530148/an-industry-update-what-is-new-in-the-field-of-therapeutic-delivery-this-month
#13
Elaine Harris
The present industry update covers the period 1-28 February 2017. Information was sourced primarily from company press releases, regulatory and patent agencies, scientific literature and various news websites. A report issued this month indicated that the recent American election has influenced the rate and volume of pharma acquisitions and mergers (A&M) in the final quarter of 2016 and it remains to be seen what (if any) is the effect on the therapeutic drug delivery sector in the longer term. There was positive approval news this month for Valeant, Intellipharmaceutics and Pfizer for products that offered novel therapeutic delivery...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530147/exposing-the-tumor-microenvironment-how-gold-nanoparticles-enhance-and-refine-drug-delivery
#14
Lawrence Tamarkin, David G I Kingston
No abstract text is available yet for this article.
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530146/an-emerging-integration-between-ionic-liquids-and-nanotechnology-general-uses-and-future-prospects-in-drug-delivery
#15
Tânia Santos de Almeida, Ana Júlio, Joana Portugal Mota, Patrícia Rijo, Catarina Pinto Reis
There is a growing need to develop drug-delivery systems that overcome drawbacks such as poor drug solubility/loading/release, systemic side effects and limited stability. Ionic liquids (ILs) offer many advantages and their tailoring represents a valuable tuning tool. Nano-based systems are also prized materials that prevent drug degradation, enhance their transport/distribution and extend their release. Consequently, structures containing ILs and nanoparticles (NPs) have been developed to attain synergistic effects...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530145/bioengineered-liposome-scaffold-composites-as-therapeutic-delivery-systems
#16
Claudia Zylberberg, Sandro Matosevic
The therapeutic potential of liposomes can be amplified when combined with biomaterial scaffolds. Such configurations overcome the convergent demands of therapies by enabling enhanced delivery, environmental responsiveness and potency. Liposomes benefit from the increased physical and mechanical strength, favorable rheological properties and natural environment conducive to improved tissue formation that scaffolds provide, while enabling biocompatible delivery of hydrophilic and lipophilic compounds that can be further functionalized to achieve targeted delivery...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530144/disulfide-conjugation-chemistry-a-mixed-blessing-for-therapeutic-drug-delivery
#17
Maarten Danial, Almar Postma
No abstract text is available yet for this article.
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28530143/intranasal-melatonin-nanoniosomes-pharmacokinetic-pharmacodynamics-and-toxicity-studies
#18
Aroonsri Priprem, Jeffrey R Johns, Sucharat Limsitthichaikoon, Wanwisa Limphirat, Pramote Mahakunakorn, Nutjaree Prateepawanit Johns
AIM: Intranasal melatonin encapsulated in nanosized niosomes was preclinically evaluated. METHODOLOGY: A formula of melatonin niosomes (MN) was selected through physicochemical and cytotoxic data for pharmacokinetic, pharmacodynamics and toxicity studies in male Wistar rats. RESULTS: Intranasal MN was bioequivalent to intravenous injection of melatonin, providing therapeutic level doses. Acute and subchronic toxicity screening showed no abnormal signs, symptoms or hematological effects in any animals...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28470113/nebulized-drug-delivery-in-respiratory-medicine-what-does-the-future-hold
#19
John N Pritchard
In the later half of the 20th century, nebulized therapy was in decline, but in the 21st century the prospects for the expanded use of nebulized therapy within respiratory medicine look bright. The advent of mesh nebulizers, which combine the universal applicability of the nebulizer in the treatment of all respiratory patients with the convenience of portable inhaler use, is ideally timed to capitalize on the forecast of increased numbers of patients who will require nebulized therapy in the future. This special report will highlight some of the opportunities that the development of mesh nebulizers presents in the field of respiratory medicine...
June 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28222661/an-industry-update-what-are-the-latest-developments-in-the-field-of-therapeutic-delivery-industry-update-1st-december-to-31st-december-2016
#20
Peter Timmins
No abstract text is available yet for this article.
April 2017: Therapeutic Delivery
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