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Therapeutic Delivery

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https://www.readbyqxmd.com/read/30444462/spray-congealing-a-versatile-technology-for-advanced-drug-delivery-systems
#1
Serena Bertoni, Luisa S Dolci, Beatrice Albertini, Nadia Passerini
Spray congealing is a low cost, simple and versatile method to produce microparticles without the use of organic or aqueous solvent. This review provides a detailed picture of the pharmaceutical applications of this technology, with an overview of the spray-congealed-based drug-delivery systems. First, the basic principles and equipment of spray congealing technology are presented. Then, representative examples of the drug-delivery systems are examined and critically discussed. Emphasis is given on the role of formulation variables, together with practical considerations for formulation design...
November 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30444461/eudragit-%C3%A2-based-microcapsules-of-probucol-with-a-gut-bacterial-processed-secondary-bile-acid
#2
Armin Mooranian, Nassim Zamani, Momir Mikov, Svetlana Goločorbin-Kon, Goran Stojanovic, Frank Arfuso, Hani Al-Salami
AIM: Deoxycholic acid (DCA) has improved gliclazide oral absorption, while Eudragit® (ED) polymers have improved formulation stability of antidiabetic drugs. The aim of the study is to test if DCA and ED encapsulation will optimize the release and stability of the potential antidiabetic drug probucol (PB). MATERIALS & METHODS:  The PB formulations were prepared using ED polymers and DCA, and formulations were analyzed for their rheological and biological properties...
November 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30444460/industry-update-the-latest-developments-in-the-field-of-therapeutic-delivery-july-2018
#3
Peter Timmins
No abstract text is available yet for this article.
November 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30444459/photodynamic-therapy-of-cancer-with-liposomal-photosensitizers
#4
Nejat Düzgüneş, Jaroslaw Piskorz, Paulina Skupin-Mrugalska, Tomasz Goslinski, Jadwiga Mielcarek, Krystyna Konopka
The photodynamic reaction involves the light-induced generation of an excited state in a photosensitizer molecule (PS), which then results in the formation of reactive oxygen species in the presence of oxygen, or a direct modification of a cellular molecule. Most PSs are porphyrinoids, which are highly lipophilic, and are administered usually in liposomes to facilitate their effective delivery to target cells. The currently available liposomal formulations are Visudyne® and Fospeg® . Novel PSs were developed and tested for their photodynamic activity against cancer cells...
November 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30444456/industry-update-covering-august-2018
#5
Louise Rosenmayr-Templeton
No abstract text is available yet for this article.
November 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30444455/long-circulating-liposomes-challenges-and-opportunities
#6
Suyash Deodhar, Alekha K Dash
The poor pharmacokinetic parameters and low solubility of many anticancer therapeutics have warranted the use of drug-delivery systems such as liposomes. Overcoming some drawbacks of the conventional liposomes, targeted liposomal delivery by longer circulation time by addition of poly(ethylene glycol) to the liposomal surface and further adding specific ligands to achieve ligand selective retention and uptake has been introduced. PEGylated liposomes are the only second-generation liposomal formulations in clinical use and are now being challenged with the allergenic response they pose even in the treatment of naive patients...
November 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30444454/stabilizing-supersaturated-drug-delivery-system-through-mechanism-of-nucleation-and-crystal-growth-inhibition-of-drugs
#7
Prachi Joshi, Abhay T Sangamwar
A supersaturated drug-delivery system is capable of enhancing oral bioavailability of hydrophobic drugs. Maintenance of the supersaturated system both in vitro and in vivo is one of the most challenging parts, for that it is required to keenly understand the nucleation and crystal growth behavior. Polymers are widely used to stabilize supersaturated solutions; screening of polymers is done on the basis of their interaction with drug. Nucleation and crystal growth inhibition and drug-polymer interactions can be investigated by using various spectroscopic methods...
November 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30277138/formulation-of-rna-interference-based-drugs-for-pulmonary-delivery-challenges-and-opportunities
#8
Kaushik Thanki, Kevin G Blum, Aneesh Thakur, Fabrice Rose, Camilla Foged
With recent advances in the field of RNAi-based therapeutics, it is possible to make any target gene 'druggable', at least in principle. The present review focuses on aspects critical for pulmonary delivery of formulations of nucleic acid-based drugs. The first part introduces the therapeutic potential of RNAi-based drugs for the treatment of lung diseases. Subsequently, we discuss opportunities for formulation-enabled pulmonary delivery of RNAi drugs in light of key physicochemical properties and physiological barriers...
October 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30277137/emerging-therapeutic-nanotechnologies-in-pancreatic-cancer-advances-risks-and-challenges
#9
Ana Rebelo, Catarina Reis
No abstract text is available yet for this article.
October 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30277136/industry-update-covering-june-2018
#10
Iain Simpson
No abstract text is available yet for this article.
October 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30277135/long-lasting-immunosuppressive-effects-of-tacrolimus-loaded-micelle-nk61060-in-preclinical-arthritis-and-colitis-models
#11
Takamichi Sato, Junpei Konno, Akihiro Sekiguchi, Nao Yoneki, Kana Kawano, Tomohiro Hayashi, Yukina Ogawa, Aya Kikitsu, Takashi Aijima, Kazuhisa Hara, Shintaro Hara, Hitomi Hayashi, Kimiko Fuchigami, Naoko Igo, Yuki Takashima, Yuki Kobayashi, Masayuki Mori, Keiichiro Yamamoto, Makoto Niwa, Kan Saiga, Eiji Ichimura
AIM: Tacrolimus (TAC) is an important drug for inflammatory diseases. However, TAC has several limitations, such as variable trough concentrations among individuals and a high medication frequency. In this study, we created NK61060, a novel micellar TAC formulation, to circumvent these disadvantages. MATERIALS & METHODS: Immunosuppressive activity of NK61060 was determined in the collagen-induced arthritis rat model, mannan-induced arthritis mouse model and dextran sodium sulfate-induced colitis mouse model...
October 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30277134/sodium-alginate-capsulation-increased-brain-delivery-of-probucol-and-suppressed-neuroinflammation-and-neurodegeneration
#12
John Cl Mamo, Virginie Lam, Hani Al-Salami, Emily Brook, Armin Mooranian, Michael Nesbit, Liam Graneri, Zachary D'Alonzo, Nicholas Fimognari, Andrea Stephenson, Ryusuke Takechi
AIM: To enhance the bioavailability and brain uptake of probucol and examine whether it attenuates neuroinflammation and neurodegeneration by utilizing a sodium alginate nanoencapsulation technique. MATERIALS & METHODS: Wild-type mice were given either low-fat standard chow, high-fat (HF) diet to induce neuroinflammation and neurodegeneration, HF diet supplemented with nanocapsuled probucol at a concentration of 0.1% (w/w), HF diet supplemented with noncapsulated probucol at the same concentration of 0...
October 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30277133/bioformulative-concepts-on-intracellular-organ-specific-bioavailability
#13
Nikhitha K Shanmukhan, Arun Radhakishnan, Vinoth Maniarasan, Gowthamarajan Kuppusamy, Samuel Gideon
Bioavailability is an ancient but effective terminology by which the entire therapeutic efficacy of a drug directly or indirectly relays. Despite considering general plasma bioavailability, specific organ/tissue bioavailability will pave the path to broad spectrum dose calculation. Clear knowledge and calculative vision on bioavailability can improve the research and organ-targeting phenomenon. This article comprises a detailed introduction on bioavailability along with regulatory aspects, kinetic data and novel bioformulative approaches to achieve improved organ specific bioavailability, which may not be readily related to blood plasma bioavailability...
October 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30277132/thiol-redox-sensitive-cationic-polymers-for-dual-delivery-of-drug-and-gene
#14
Priya Sahadevan Syamala, Rekha Mannemcherril Ramesan
Recently greater emphasis has been given to combination therapy for generating synergistic effects of treating cancer. Recent studies on thiol-sensitive nanocarriers for the delivery of drug or gene have shown promising results. In this review, we will examine the rationale and advantage in using nanocarriers for the combined delivery of different anticancer drugs and biologics. Here, we also discuss the role of nanocarriers, particularly redox-sensitive polymers in evading or inhibiting the efflux pump in cancer and how they modulate the sensitivity of cancer cells...
October 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30189811/binary-and-ternary-complexes-of-norfloxacin-to-improve-the-solubility-of-the-active-pharmaceutical-ingredient
#15
Micaela Ponce-Ponte, Carolina Aloisio, Diana Marcela Romero-Guerra, Sandra Gracia-Vásquez, Claudia Garnero, Marcela Longhi
AIM: Binary and ternary complexes with hydroxypropyl-β-cyclodextrin (HPβCD), using glutamic acid (GA), proline or lysine as the third component, were developed to increase the solubility and the dissolution rate of norfloxacin (NOR). METHODS/RESULTS: Complexation was evaluated by phase solubility studies, obtaining the highest NOR solubility with GA and HPβCD. Thermal analysis suggested that different kinds of interactions occur among NOR, HPβCD and each amino acid, and when the systems were prepared by kneading or by means of freeze-drying technique...
September 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30189810/industry-update-covering-april-2018
#16
Iain Simpson
No abstract text is available yet for this article.
September 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30189809/nonlamellar-liquid-crystals-a-new-paradigm-for-the-delivery-of-small-molecules-and-bio-macromolecules
#17
Sandeep Urandur, Disha Marwaha, Shalini Gautam, Venkatesh T Banala, Madhu Sharma, Prabhat R Mishra
The aim of this article is to collate the recent developments in the field of drug delivery, medical therapeutics and diagnostics specifically involving the nonlamellar liquid crystalline (NLC) systems. This review highlights different NLC phases having cubic, hexagonal and sponge internal structures, and their application in the field of drug delivery, such as dose reduction, toxicity reduction and therapeutic efficacy enhancement either in the form of nanoparticles, colloidal dispersion or gels. In addition, application of NLC systems as vehicles for peptides, proteins and as a theranostic system in cancer and other disease conditions is also elaborated, which is a growing platform of interest...
September 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30189808/development-and-in-vitro-evaluation-of-solid-dispersions-as-strategy-to-improve-albendazole-biopharmaceutical-behavior
#18
Analía Simonazzi, Alicia Graciela Cid, Alejandro Javier Paredes, Laureano Schofs, Elio Emilio Gonzo, Santiago Daniel Palma, José María Bermúdez
AIM: Solid dispersions using Poloxamer 407 as carrier were developed to improve albendazole (ABZ) solubility and dissolution profiles. METHODS: ABZ/poloxamer solid dispersions were prepared, and dissolution profiles were mathematically modeled and compared with physical mixtures, pharmaceutical ABZ and a commercial formulation. RESULTS: Poloxamer 407 increased exponentially ABZ solubility, in about 400% when 95% w/w of polymer compared with its absence...
September 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30189807/non-procrustean-pathways-for-complex-generic-drugs-development
#19
Rodrigo Cristofoletti, Stephan Schmidt, Andrea Diniz
No abstract text is available yet for this article.
September 2018: Therapeutic Delivery
https://www.readbyqxmd.com/read/30189806/ibuprofen-intercalation-and-release-from-different-layered-double-hydroxides
#20
Elsie E Gaskell, Tina Ha, Ashley R Hamilton
AIM: The chemical composition of layered double hydroxides (LDHs) affects their structure and properties. The method of ibuprofen (IBU) intercalation into LDHs may modify its release, reduce adverse effects and decrease the required dosing frequency. METHODOLOGY: This study investigates the effects of four different LDHs; MgAl-LDH, MgFe-LDH, NiAl-LDH and NiFe-LDH on in vitro release of IBU intercalated by coprecipitation and anionic-exchange. RESULTS: MgAl-LDH was the most crystalline and substitution of either cation decreased LDH order...
September 2018: Therapeutic Delivery
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