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Journal of Clinical Medicine Research

Hidekatsu Yanai, Norio Tada
No abstract text is available yet for this article.
December 2018: Journal of Clinical Medicine Research
Takashi Hitsumoto
Background: The blood concentration of high-sensitivity cardiac troponin T (hs-cTnT) is a useful biomarker for myocardial injury or the pathogenesis of hypertension. Little is known about the relationship between hemorheology and myocardial injury in patients with hypertension. This cross-sectional study aimed to clarify the clinical impact of hemorheology on subclinical myocardial injury assessed with a microchannel array flow analyzer (MC-FAN) and its impact on hs-cTnT in patients with hypertension...
December 2018: Journal of Clinical Medicine Research
Kazuki Ohashi, Toru Ishikawa, Asami Hoshi, Mitsuyuki Suzuki, Yuta Mitobe, Etsuko Yamada, Hansani Madushika Abeywickrama, Nao Seki, Chikayo Koyama, Hagiko Aoki, Yu Koyama
Background: Sarcopenia can affect the prognosis of patients with cirrhosis or hepatocellular carcinoma. Exercise therapy and nutritional therapy are carried out to prevent processing sarcopenia. In addition, changing lifestyle is also important. However, there are only few reports on the physical activities (PAs) and lifestyle of chronic liver disease patients and their association with sarcopenia. The aim of this study is to examine the relationship between sarcopenia in patients with chronic liver disease and both PA and lifestyle...
December 2018: Journal of Clinical Medicine Research
Satyajeet Roy, Shirisha Vallepu, Cristian Barrios, Krystal Hunter
Background: Cancer survivors suffer from many comorbid conditions even after the cure of their cancers beyond 5 years. We explored the differences in the association of comorbid conditions between the cancer survivors and patients without cancer. Methods: Electronic medical records of 280 adult cancer survivors and 280 age-matched patients without cancer in our suburban internal medicine office were reviewed. Results: Mean age of the cancer survivors was 72...
December 2018: Journal of Clinical Medicine Research
Satomi Minato, Naoki Sakane, Kazuhiko Kotani, Shinsuke Nirengi, Ikuyo Hayashi, Akiko Suganuma, Ken Yamaguchi, Kenji Takakura, Narumi Nagai
Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder among reproductive-aged women. While PCOS is associated with an increased risk of obesity and insulin resistance, little is known regarding the prevalence of and risk factors for nonalcoholic fatty liver disease (NAFLD) among Japanese women with PCOS. We estimated the prevalence of and risk factors for elevated liver enzymes, as the index of NAFLD, in Japanese women with PCOS. Methods: We retrospectively reviewed 102 reproductive-aged women who visited the Department of Gynecology, Kyoto Medical Center in Japan from January 2000 to September 2016...
December 2018: Journal of Clinical Medicine Research
Francine Sanchez Gulin, Mayra Goncalves Menegueti, Maria Auxiliadora-Martins, Thamiris Ricci de Araujo, Fernando Bellissimo-Rodrigues, Aline Nassiff, Anibal Basile-Filho, Ana Maria Laus
Background: The aim of this study was to identify factors associated with pressure injury (PI) occurrence in critically ill patients. This was a retrospective cohort study conducted at a mixed intensive care unit (ICU). Methods: Univariate analysis and logistic regression were used to identify which variables are associated with PI. Results: Twenty-one (15%) of 142 patients developed PI. The median and the range of the variables in the groups without and with PI were as follows: Braden scale risk score, 13 (8 - 20) and 10 (8 - 14) points, respectively; Acute Physiology and Chronic Health Evaluation II (APACHE II) death risk, 39% (2 - 97%) and 75% (26 - 96%), respectively; and length of stay in the ICU, 4 (2 - 36) and 16 (5 - 29) days, respectively...
December 2018: Journal of Clinical Medicine Research
Bharat Bajantri, Omesh Toolsie, Sindhaghatta Venkatram, Gilda Diaz-Fuentes
Background: Mycoplasma pneumoniae pneumonia (MPP), or "walking pneumonia," is an atypical mild disease with varied clinical findings. Specifically, diagnosis is often controversial and understanding of disease presentation is limited. The goal of the study was to evaluate presentation, clinical associations and outcomes of MPP patients admitted to an inner-city hospital. Methods: This was a retrospective analysis of adult patients diagnosed with MPP from January 2010 to January 2017...
December 2018: Journal of Clinical Medicine Research
Takashi Hitsumoto
Background: The cardio-ankle vascular index (CAVI) is a physiologic marker reflecting arterial function. There have been no prospective studies investigating the relationship between CAVI and cardiovascular events in patients with chronic kidney disease (CKD). The aim of this prospective study was to assess the clinical usefulness of CAVI as a predictor of primary cardiovascular events in patients with CKD. Methods: The study enrolled 460 outpatients with CKD but no history of cardiovascular disease (152 men and 308 women; mean ± standard deviation age, 74 ± 12 years)...
December 2018: Journal of Clinical Medicine Research
Hiroaki Yanagawa, Hiroshi Nokihara, Hideto Yokoi, Hitoshi Houchi, Masahiro Nagai, Risako Yamashita, Narufumi Suganuma, Masamitsu Hyodo
Background: The new Clinical Trials Act that recently came into effect in Japan emphasizes the reliability of investigator-initiated clinical trials. Although Japanese clinical research coordinators have been mainly engaged in operational roles in industry-initiated clinical trials for drug approval (registration trials), broadening their contribution to cover more types of clinical research may lead to quality improvement of clinical research. To ultimately establish a clinical research infrastructure that meets the needs of the new era of Clinical Trials Act, here we gathered basic information on how clinical research coordinators might make such contributions...
December 2018: Journal of Clinical Medicine Research
Hafeez Ul Hassan Virk, Kevin Bryan Lo, Chayakrit Krittanawong, Faisal Inayat, Usman Sarwar, Ali Raza Ghani, Christian Witzke, Sean Janzer, Jon C George, Gregg Pressman, Behnam Bozorgnia, Saurav Chatterjee, Vincent M Figueredo
Background: The optimal timing of revascularization in unstable angina (UA) or non-ST-segment elevation myocardial infarction (NSTEMI) remains uncertain. We compared routine early revascularization (REV) versus selective late revascularization (SLR) strategies and divergence in the approach of cardiologists in the United States and Europe. Methods: Seventeen randomized controlled trials (RCTs) (15,812 patients) were extracted from PubMed, Cochrane Library, EMBASE and Web of Science databases...
December 2018: Journal of Clinical Medicine Research
Vasiliki Gkioka, Panagiotis Tsirigotis, Markos Sarris, Sotiris Soulis, Athanasios Apostolou, Michel Noutsias, Georgios Dimitriadis, Alkiviadis Kostakis, Ioannis Boletis, Andreas Karabinis
Progress in science and technology in the health services has led to the development of methods of regenerating and replacing solid organs, tissues and cells, using human body components to create medical products of human origin intended for clinical use. In the activities in which products of human origin are used, however, from the point of donation and harvesting to the subsequent care of the recipient, medical products of human origin are exposed to the risk of specific complications related to the transmission of infectious diseases, and further side-effects...
December 2018: Journal of Clinical Medicine Research
(no author information available yet)
[This retracts the article DOI: 10.14740/jocmr3324w.].
November 2018: Journal of Clinical Medicine Research
Renato De Vecchis, Carmelina Ariano, Silvia Soreca
No abstract text is available yet for this article.
November 2018: Journal of Clinical Medicine Research
Maya Antoine, Patrick T Reeves, Luis Rohena, Olcay Jones, Brian Faux
Juvenile dermatomyositis (JDM) is a rare, but well recognized multi-systemic inflammatory myopathy in children defined by proximal muscle weakness and distinctive skin lesions, that if recognized and treated early result in decreased morbidity and mortality. The 1975 criteria established by Bohan and Peter center around the propensity for early development of heliotrope and Gottron's lesions in combination with specific laboratory abnormalities, and are still the leading diagnostic tool. The following case demonstrates a toddler with an atypical presentation of JDM in which delayed dermatologic manifestations hindered initial diagnosis...
November 2018: Journal of Clinical Medicine Research
Aline Barbosa Moraes, Natalia Treistman, Mariana Coutinho Studart, Vera Lucia Antunes Chagas, Eloa Pereira Brabo, Leonardo Vieira Neto
Neuroendocrine tumors (NETs) of cystic duct are extremely rare, accounting for less than 2% of NET cases. The association of biliary tree NET and multiple endocrine neoplasm type 1 (MEN1) are even more rare. In this report, we described a case of a 65-year-old woman who was referred to our neuroendocrine outpatient clinic to investigate MEN1 after an incidental diagnosis of gastrinoma. Her medical history initiated 7 years earlier with severe peptic disease not responsive to proton pump inhibitor therapy. Endoscopic study revealed erosive antral gastritis, erosive duodenitis, bulbar ulcer and pyloric deformity...
November 2018: Journal of Clinical Medicine Research
Hodaka Yamada, Masafumi Kakei, Kazuo Hara
Background: Postprandial hyperglycemia is a well-known risk factor for cardiovascular disease. We prospectively examined the effects of repaglinide on postprandial hyperglycemia in patients with type 2 diabetes. Methods: During this 24-week, single-arm, prospective study, we enrolled 10 patients with type 2 diabetes who were previously being administered glimepiride (0.5 or 1 mg/day) and switched it with repaglinide (0.75 or 1.5 mg/day). Changes in their metabolic parameters were evaluated at the end of the study period...
November 2018: Journal of Clinical Medicine Research
Cosme Alvarado-Esquivel
Background: The link between suicidal behavior and premenstrual syndrome has been poorly studied. This study aimed to determine the association of suicide attempts, and suicidal ideation and signs and symptoms of premenstrual syndrome and menstrual history in women in Durango City, Mexico. Methods: Using a cross-sectional study design, 437 women were interviewed to obtain clinical data about their premenstrual period, menstrual history and suicidal behavior. Logistic regression was used to assess the association between suicide behavior and clinical features of women...
November 2018: Journal of Clinical Medicine Research
Mika Takeuchi, Satomi Minato, Kaori Kitaoka, Ayaka Tsuboi, Miki Kurata, Tsutomu Kazumi, Keisuke Fukuo
Background: To assess the relationship of the shape of glucose concentration curve during a standardized meal test to serum free fatty acid (FFA) concentrations, insulin resistance and insulin secretion in young non-obese women. Methods: Thirty-five young women had a standardized meal for breakfast with measurement of glucose, insulin and FFA concentrations at 0 (fasting), 30, 60 and 120 min; the areas under the concentration curves were calculated (AUCg, AUCi and AUCffa, respectively)...
November 2018: Journal of Clinical Medicine Research
Shin-Ichiro Masunaga, Junya Kobayashi, Keizo Tano, Yu Sanada, Minoru Suzuki, Koji Ono
Background: The aim of the study was to clarify the effect of p53 status of tumor cells on radio-sensitivity of solid tumors following γ-ray irradiation at various dose rates, referring to the response of intratumor quiescent (Q) cells. Methods: Human head and neck squamous cell carcinoma cells transfected with mutant TP53 (SAS/ mp53 ) or with neo vector (SAS/ neo ) were injected subcutaneously into hind legs of nude mice. Tumor bearing mice received 5-bromo-2'-deoxyuridine (BrdU) continuously to label all intratumor proliferating (P) cells...
November 2018: Journal of Clinical Medicine Research
John Peabody, Maria Czarina Acelajado, Tim Robert, Cheryl Hild, Joshua Schrecker, David Paculdo, Mary Tran, Elaine Jeter
Background: Drug-drug interactions (DDIs) are ubiquitous, harmful and a leading cause of morbidity and mortality. With an aging population, growth in polypharmacy, widespread use of supplements, and the rising opioid abuse epidemic, primary care physicians (PCPs) are increasingly challenged with identifying and preventing DDIs. We set out to evaluate current clinical practices related to identifying and treating DDIs and to determine if opportunities to increase prevention of DDIs and their adverse events could be identified...
November 2018: Journal of Clinical Medicine Research
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