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Journal of Clinical Medicine Research

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https://www.readbyqxmd.com/read/29977426/bofutsushosan-significantly-ameliorated-betamethasone-induced-cushing-s-syndrome
#1
Hidekatsu Yanai
No abstract text is available yet for this article.
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29977425/unusual-features-of-clear-cell-adenocarcinoma-of-the-female-urethra-a-case-report-and-literature-review
#2
Jianfeng Zeng, Shanyun Wang, Liang Zhong, Zhifeng Huang, Ye Zeng, Song Wu, Dongxiang Zheng, Weiwei Zou, Haibiao Lai
Background: There has been scarce information about clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer. A few case reports show that CCAU tends to have similar clinical manifestation to the other urethral carcinomas, urethrocystoscopy can easily identify tumoral lesions in the urethra, and bloody drainage from the urethral meatus is often seen during physical exams. Methods: A 52-year-old woman presented with dysuria for 6 months. Urethrocystoscopy did not reveal abnormality, and there was no bloody vaginal drainage or bloody drainage from the urethral meatus during physical exams...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29977424/pretreatment-lymphocyte-to-monocyte-ratio-as-a-prognostic-marker-for-advanced-pulmonary-squamous-cell-carcinoma-treated-with-chemotherapy
#3
Seigo Minami, Shouichi Ihara, Kiyoshi Komuta
Background: Lower lymphocyte to monocyte ratio (LMR), higher neutrophil to lymphocyte ratio (NLR) and modified Glasgow prognostic score (mGPS) 2 have been demonstrated as independent prognostic markers for poor prognosis of advanced non-small cell lung cancer (NSCLC). However, little is known about these three markers as prognostic markers for a specific histological subset of NSCLC, squamous cell carcinoma (SCC). This study aimed to evaluate the prognostic significance of LMR, NLR and mGPS for advanced SCC...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29977423/effect-of-anagliptin-on-glycemic-and-lipid-profile-in-patients-with-type-2-diabetes-mellitus
#4
Yukari Chiba, Tadashi Yamakawa, Hirohisa Tsuchiya, Mari Oba, Daisuke Suzuki, Hirosuke Danno, Yoji Takatsuka, Hiroshi Shigematsu, Mizuki Kaneshiro, Yasuo Terauchi
Background: Anagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor expected to improve the lipid profile as well as glycemic control. However, findings from large-scale prospective trials have not been obtained. Methods: We performed a multicenter prospective trial in patients with type 2 diabetes receiving anagliptin to evaluate its effect on glycemic control and the lipid profile. A total of 95 patients received anagliptin at 200 mg twice daily. Markers of glucose and lipid metabolism were measured at baseline and after 12 and 24 weeks of administration, and the absolute changes and percent changes were determined...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29977422/efficacy-and-patient-satisfaction-of-dipeptidyl-peptidase-4-inhibitor-after-switching-from-once-daily-dpp-4-inhibitor-to-once-weekly-regimen
#5
Katsunori Suzuki, Kazuki Hasegawa, Mio Watanabe
Background: We administered once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor (W) (used omarigliptin as W in this study) to patients with type 2 diabetes taking once-daily DPP-4 inhibitor (D), and investigated efficacy, safety and patient satisfaction before and after switching to W. Methods: W was administered to 182 patients with type 2 diabetes taking D (used sitagliptin as D in this study), who had been visiting our hospital on an outpatient basis; 164 (90...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29977421/the-characteristics-and-trends-in-adrenocortical-carcinoma-a-united-states-population-based-study
#6
Eliza Sharma, Suyash Dahal, Pratibha Sharma, Abani Bhandari, Vishal Gupta, Birendra Amgai, Sumit Dahal
Background: Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Data on the incidence of ACC, however, are scarce and not recent. The purpose of this study was to characterize the tumor and the patients developing ACC over the last four decades using a large population based database. Methods: We identified all cases of ACC diagnosed between 1973 - 2014 from the Surveillance, Epidemiology, and End Results-18 registry. Descriptive analyses were used for all extracted demographic, clinical, pathological, therapeutic and survival data, and were compared between the four time periods of 1973 to 1984, 1985 to 1994, 1995 to 2004 and 2005 to 2014 using Chi-square tests for categorical variables and one-way analysis of variance for continuous variables...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29977420/association-between-visceral-fat-accumulation-and-exercise-tolerance-in-non-obese-subjects-without-diabetes
#7
Miki Shioya-Yamada, Kazunori Shimada, Miho Nishitani-Yokoyama, Eiryu Sai, Kageumi Takeno, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Hiroyuki Daida, Sachio Kawai
Background: We examined the associations between visceral fat accumulation, presence of the components of metabolic syndrome (MetS), and exercise tolerance in non-obese subjects without diabetes. Methods: Seventy-four non-obese, non-diabetic Japanese men were enrolled. The subjects were divided into the following two groups: non-obese subjects without any MetS risk factors (n = 38, Group A) and non-obese subjects with one or two MetS risk factors (n = 36, Group B)...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29977419/is-there-a-role-for-diagonal-coronary-artery-stenting-in-patients-undergoing-robotic-coronary-artery-bypass-graft-surgery
#8
Jeevan Nagendran, Chris Tarola, Jorge Catrip, Stephanie A Fox, Michael W A Chu, Patrick Teefy, Kumar Sridhar, Pantelis Diamantouros, Bob Kiaii
Background: The efficacy of diagonal coronary artery stenting in patients undergoing robotic left internal thoracic artery-to-left anterior descending (LITA-to-LAD) anastomosis is not well defined. The objective of this study was to assess graft and stent patency in a single-stage hybrid revascularization with LITA-to-LAD anastomosis and PCI to a diagonal coronary artery. Methods: From 2004 to 2014, a total of 25 patients consented to robotic-assisted LITA harvesting and a small left anterior thoracotomy for off-pump coronary artery bypass anastomosis onto the LAD along with concomitant PCI to the diagonal coronary artery...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29977418/sglt-2-inhibitors-and-cardiovascular-protection-lessons-and-gaps-in-understanding-the-current-outcome-trials-and-possible-benefits-of-combining-sglt-2-inhibitors-with-glp-1-agonists
#9
REVIEW
Elamin Abdelgadir, Fauzia Rashid, Alaaeldin Bashier, Razan Ali
Landmark trials on diabetes control have shown variable results in terms of cardiovascular benefits, with the majority showing a favorable effect of glycemic control on microvascular and, more recently, macrovascular complications. However, some trials pointed out a CV hazard with tight diabetes mellitus (DM) control. Most of those trials were assessing the impact of glycemic control, more than evaluating the effect of a certain medication. In the last decade, food and drugs administration (FDA) has mandated that all new hypoglycemic agents run a CV outcome trial (CVOT) for safety in order to grant and sustain approval...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29977417/ear-involvement-in-inflammatory-bowel-disease-a-review-of-the-literature
#10
REVIEW
Fotios S Fousekis, Maria Saridi, Eleni Albani, Fady Daniel, Konstantinos H Katsanos, Ioannis G Kastanioudakis, Dimitrios K Christodoulou
Inflammatory bowel disease (IBD) is a multisystemic disease. The ear is a rare but recognized site of extraintestinal manifestations of IBD. In external ear, the more common manifestations of IBD are pyoderma gangrenosum, metastatic Crohn's disease and relapsing polychondritis and the treatment includes corticosteroids and anti-TNF agents. Sensorineural hearing loss (SNHL) is the most common ear disease in IBD and especially in patients with ulcerative colitis. In most cases of IBD patients with SNHL, the hearing loss is attributable to autoimmune inner ear disease (AIED)...
August 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904447/which-factor-determines-the-duration-required-for-relief-of-glucotoxicity-by-the-intensive-insulin-therapy
#11
Hidekatsu Yanai, Mariko Hakoshima, Hiroki Adachi
No abstract text is available yet for this article.
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904446/secondary-salivary-gland-malignancy-in-thyroid-cancer-a-united-states-population-based-study
#12
Eliza Sharma, Suyash Dahal, Pratibha Sharma, Abani Bhandari, Vishal Gupta, Sumit Dahal
Background: There is an increased risk of second primary malignancies with thyroid cancer. However, the risk and characters of secondary salivary gland malignancy (sSGM) in patients with thyroid cancer have not been evaluated before. Methods: We used the Surveillance Epidemiology and End Results (SEER) 18 registry to identify thyroid cancer patients from 1973 to 2014. We then calculated the risk of sSGM using standardized incidence ratio and excess risk. Separately, all cases of primary salivary gland malignancy (pSGM) diagnosed between 1973 - 2014 were extracted from the SEER 18 registry, and their characteristics compared with sSGM using independent samples t -test for continuous variables and Chi-square tests for categorical variables...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904445/malignant-ventricular-arrhythmias-resulting-from-drug-induced-qtc-prolongation-a-retrospective-study
#13
Renato De Vecchis, Carmelina Ariano, Giuseppina Di Biase, Michel Noutsias
Background: Several drug classes (antiarrhythmics, antimicrobials, antidepressants, phenothiazines, opiates, prokinetics of digestive tract, etc.) have been related to ventricular hyperkinetic arrhythmias such as torsade de pointes (TdP). TdPs are usually heralded by an abnormal prolongation of heart rate-corrected QT interval on the electrocardiogram, so-called drug-induced long heart rate-corrected QT (diLQTc). We don't know to what extent the drug-induced QTc prolongation is able to predict malignant arrhythmias...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904444/the-impact-of-nutritional-status-and-complete-blood-count-parameters-on-clinical-outcome-in-geriatric-critically-ill-patients
#14
Abdulkerim Yildiz, Ali Yigit, Ali Ramazan Benli
Background: The geriatric population in intensive care units (ICUs) has recently increased. The aim of this study was to analyse the impact of initial complete blood count (CBC)-related parameters and nutritional status on morbidity and mortality in geriatric ICU patients. Methods: A retrospective analysis was made of geriatric patients admitted to our tertiary adult ICU for 1 year. Patients with a length of stay (LOS) of < 48 h, with hematological malignancy or age < 65 years age were excluded from the study...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904443/critical-event-intervals-in-determining-candidacy-for-intravenous-thrombolysis-in-acute-stroke
#15
John S Garrett, Steven Sonnamaker, Yahya Daoud, Hao Wang, Dion Graybeal
Background: The aim of the study was to determine the optimal set point for the critical event benchmarks described in stroke guidelines and validate the ability of these goals to predict successful administration of intravenous thrombolysis within 60 min of hospital arrival. Methods: This was a retrospective cohort analysis of patients with acute ischemic stroke who received intravenous thrombolysis following presentation to the emergency department. The national benchmarks for time intervals associated with the completion of critical events required to determine candidacy for thrombolysis were evaluated for the ability to predict successful administration of thrombolysis within 60 min of hospital arrival...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904442/characteristics-and-factors-associated-with-the-mortality-of-hypotensive-patients-attending-the-emergency-department
#16
Kumpol Amnuaypattanapon, Suwimon Khansompop
Background: The prevalence of hypotension in emergency departments (EDs) is approximately 1-2%, but is associated with a mortality rate of 8-15%. There has never been a study in Thailand examining the epidemiology or the risk factors for early mortality of patients presenting with hypotension in the ED. Therefore, this study aimed to define the characteristics, mortality rate within 48 h and associated factors of hypotensive patients at ED. Methods: Data of patients with hypotension attending the ED of Thammasat University Hospital (TUH) were retrospectively studied...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904441/ischemic-modified-albumin-predicts-critical-coronary-artery-disease-in-unstable-angina-pectoris-and-non-st-elevation-myocardial-infarction
#17
Abdullah Orhan Demirtas, Turgut Karabag, Derya Demirtas
Background: In this study, whether ischemia modified albumin (IMA) has a role in showing severity or criticality of coronary arteries in patients with unstable angina pectoris (USAP)/non-ST-elevation myocardial infarction (NSTEMI) was assessed. Methods: A total of 65 patients (40 male (M) and 25 female (F) patients; mean age 59.7 ± 12.1 years) with the initial diagnosis of USAP/NSTEMI were included in this study. The levels of IMA, troponin T, creatine kinase MB (CK-MB), C-reactive protein (CRP), brain natriuretic peptide (BNP), creatinine, lipid panel, and whole blood count were measured from venous blood obtained from each patient within 3 h after the onset of symptoms...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904440/serum-free-light-chains-in-neoplastic-monoclonal-gammopathies-relative-under-detection-of-lambda-dominant-kappa-lambda-ratio-and-underproduction-of-free-lambda-light-chains-as-compared-to-kappa-light-chains-in-patients-with-neoplastic-monoclonal-gammopathies
#18
Won Sok Lee, Gurmukh Singh
Background: Quantitative evaluation of serum free light chains is recommended for the work up of monoclonal gammopathies. Immunoglobulin light chains are generally produced in excess of heavy chains. In patients with monoclonal gammopathy, κ/λ ratio is abnormal less frequently with lambda chain lesions. This study was undertaken to ascertain if the levels of overproduction of the two light chain types and their detection rates are different in patients with neoplastic monoclonal gammopathies...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904439/multiplexed-microsphere-suspension-array-assay-for-urine-mitochondrial-dna-typing-by-c-stretch-length-in-hypervariable-regions
#19
Kimiko Aoki, Hiroyuki Tanaka, Takashi Kawahara
Background: The standard method for personal identification and verification of urine samples in doping control is short tandem repeat (STR) analysis using nuclear DNA (nDNA). The DNA concentration of urine is very low and decreases under most conditions used for sample storage; therefore, the amount of DNA from cryopreserved urine samples may be insufficient for STR analysis. We aimed to establish a multiplexed assay for urine mitochondrial DNA typing containing only trace amounts of DNA, particularly for Japanese populations...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904438/the-use-of-serum-procalcitonin-as-a-diagnostic-and-prognostic-biomarker-in-chronic-obstructive-pulmonary-disease-exacerbations-a-literature-review-update
#20
REVIEW
Nikolaos-Dimitrios Pantzaris, Diamantina-Xanthi Spilioti, Aikaterini Psaromyalou, Ioanna Koniari, Dimitrios Velissaris
Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are a major complication in COPD patients which can be triggered by bacterial or viral infections, environmental pollutants and other causes. Procalcitonin (PCT), a peptide that markedly increases in cases of bacterial infection, has been extensively investigated as a biomarker in the diagnosis, prognosis and treatment in patients with AECOPD. A number of studies published in the last decade, tried to investigate whether PCT levels can differentiate between bacterial and other causes of exacerbations, if they can be used as a guide for optimal antibiotic therapy and if they can be a tool in the assessment of the severity and the need for further interventions in the management of those patients...
July 2018: Journal of Clinical Medicine Research
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