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Journal of Clinical Medicine Research

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https://www.readbyqxmd.com/read/27829962/successful-closure-of-a-ventricular-septal-defect-using-a-novel-non-prosthesis-touching-technique-following-mechanical-aortic-valve-replacement
#1
Xinghua Gu, Hourong Sun, Lei Zhang, Changjing Qi, Kejie Cai, Xiquan Zhang
Percutaneous intervention is preferred over reoperation for the treatment of iatrogenic membranous ventricular septal defects (VSDs). During the standard percutaneous procedure, an arterio-venous loop is used for occluder deployment, entailing the risk of device impingement on the prosthetic aortic valve, which may cause serious complications or even death. In this report, we describe a novel non-prosthesis touching procedure for the closure of a VSD in a patient with prior aortic valve replacement. The unique feature of this technique is the use of an apex-venous loop for occluder deployment, which prevents the device impingement on the prosthetic valve, thus avoiding difficulties, lengthy operation and serious complications associated with the standard procedure...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829961/fulminant-hepatic-failure-secondary-to-herpes-hepatitis-in-a-patient-with-myasthenia-crisis-an-elusive-diagnosis
#2
Harish Patel, Hassan Tariq, Vinaya Gaduputi, Trupti Vakde, Jasbir Makker, Myrta Daniel
Herpes hepatitis is a rare cause of fulminant hepatic failure contributing to less than 1% of all cases. It is most often seen in persons who are immunosuppressed and in pregnant women. The presentation is usually non-specific and rapidly progressive, thus making antemortem diagnosis of this condition rare. We present a patient who was on chronic immunosuppressive therapy for systemic lupus erythematosus and subsequently developed multi-organ failure with anicteric transaminitis as a result of disseminated herpes infection...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829960/ketoacidosis-in-a-non-diabetic-adult-with-chronic-etoh-consumption
#3
Catherine-Audrey Boutin, Mikhael Laskine
Although much more rare than its diabetic counterpart, ketoacidosis secondary to alcohol withdrawal in the context of fasting has its own complex pathophysiology and can easily mimic the acute insulin deficiency presentation. We present here a rare case of a non-diabetic alcoholic patient who presented in ketoacidosis after a period of reduced intake.
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829959/propionibacterium-acnes-time-to-positivity-in-standard-bacterial-culture-from-different-anatomical-sites
#4
Rasha Abdulmassih, Jina Makadia, James Como, Michelle Paulson, Zaw Min, Nitin Bhanot
BACKGROUND: Propionibacterium acnes infections are likely under-recognized and underreported. This is partly because of low clinical suspicion, perceived non-pathogenicity, or lack of adequate culture incubation time. We conducted a study to assess the optimal incubation period to recover P. acnes from specimens acquired during the workup of suspected clinical infections. METHODS: A 5-year retrospective chart review was conducted between January 2010 and December 2014 at a single tertiary-care hospital...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829958/antioxidant-and-renoprotective-effects-of-mushroom-extract-implication-in-prevention-of-nephrolithiasis
#5
Ariel Schulman, Matthew Chaimowitz, Muhammad Choudhury, Majid Eshghi, Sensuke Konno
BACKGROUND: The pathogenesis of nephrolithiasis (kidney stone) remains elusive, while several therapeutic options are available but not effective as we expected. Accumulating data yet suggest that oxidative stress (generation of oxygen free radicals) may play a primary role in its occurrence. Particularly, calcium oxalate (CaOx) is a key element in the most common form (> 75%) of kidney stones, and its crystal form known as CaOx monohydrate (COM) has been shown to exert oxidative stress, facilitating CaOx stone formation...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829957/evaluation-of-the-antithrombotic-effects-of-rivaroxaban-and-apixaban-using-the-total-thrombus-formation-analysis-system-%C3%A2-in-vitro-and-ex-vivo-studies
#6
Hidekazu Sugihara, Yoshiaki Idemoto, Takashi Kuwano, Yoshihisa Nagata, Joji Morii, Makoto Sugihara, Masahiro Ogawa, Shin-Ichiro Miura, Keijiro Saku
BACKGROUND: The usefulness of the Total Thrombus-Formation Analysis System(®) (T-TAS(®)) for monitoring the anticoagulant effects of non-vitamin K oral anticoagulants (NOACs) in clinical practice has been poorly addressed. METHODS: NOACs (rivaroxaban and apixaban) were added to whole blood from healthy subjects in an in vitro study, and their effects on thrombus formation were evaluated by the T-TAS(®). We also evaluated antithrombotic effects using ex vivo samples of whole blood from patients given rivaroxaban or apixaban at the respective trough and peak drug concentrations...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829956/bi-luminal-mitral-valve-incidence-clinical-features-associated-anomaly-and-echocardiographic-evaluation
#7
Santosh Kumar Sinha, Vikas Mishra, Karandeep Singh, Mohammad Asif, Mohit Sachan, Ashutosh Kumar, Mukesh Jitendra Jha, Dibbendhu Khanra, Avinash Kumar Singh, Shravan Singh, Mahamdula Razi, Ramesh Thakur, Umeshwar Pandey, Chandra Mohan Varma
OBJECTIVE: The aim of the study was to know the incidence, clinical features, associated anomaly and echocardiographic evaluation of bi-luminal mitral valve (also known as double orifice mitral valve or DOMV) in patients with suspected mitral valve disease, continous murmur or left-to-right shunt. METHODS: Twenty-eight patients with DOMV were diagnosed by transthoracic echocardiography (TTE) in a retrospective review of 52,256 echocardiographic studies in 45,898 patients performed between 2000 and 2015...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829955/efficacy-and-safety-of-a-single-pill-fixed-dose-combination-of-azilsartan-and-amlodipine
#8
Kota Motozato, Shin-Ichiro Miura, Yuhei Shiga, Takaaki Kusumoto, Keijiro Saku
BACKGROUND: Guidelines for the management of hypertension recommend the use of drugs with different mechanisms of action in antihypertensive regimens that include single-pill fixed-dose combinations of medications. There is some controversy regarding which single-pill fixed-dose combinations of angiotensin II type 1 receptor blockers (ARBs) and calcium channel blockers (CCBs) are effective at reducing blood pressure (BP). METHODS: Forty hypertensive patients who were receiving a single-pill fixed-dose combination of valsartan 80 mg/day and amlodipine 5 mg/day or irbesartan 100 mg/day and amlodipine 5 mg/day were enrolled...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829954/the-effects-of-ramelteon-on-glucose-metabolism-and-sleep-quality-in-type-2-diabetic-patients-with-insomnia-a-pilot-prospective-randomized-controlled-trial
#9
Tetsuji Tsunoda, Masayo Yamada, Tomoaki Akiyama, Taichi Minami, Taishi Yoshii, Yoshinobu Kondo, Shinobu Satoh, Yasuo Terauchi
BACKGROUND: Insomnia is associated with the onset and development of diabetes. Melatonin affects sleep quality and glucose metabolism in diabetic patients with insomnia. We administered ramelteon, an agonist of melatonin, to type 2 diabetic patients and investigated its effects on glucose metabolism and insomnia. METHODS: This multicenter, prospective, randomized, and observational pilot study was performed between April 2014 and April 2015 at three institutes in Japan...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829953/high-prevalence-of-toxoplasma-gondii-infection-in-miners-a-case-control-study-in-rural-durango-mexico
#10
Cosme Alvarado-Esquivel, Sandy Janet Pacheco-Vega, Jesus Hernandez-Tinoco, Luis Omar Berumen-Segovia, Luis Francisco Sanchez-Anguiano, Sergio Estrada-Martinez, Ada Agustina Sandoval-Carrillo, Jose Manuel Salas-Pacheco, Oliver Liesenfeld, Elizabeth Irasema Antuna-Salcido
BACKGROUND: Very little is known about the seroepidemiology of infection with the parasite Toxoplasma gondii (T. gondii) in miners. We determine the association of T. gondii infection and the occupation of miner, and the association of seropositivity for T. gondii with the socio-demographic, clinical, work and behavioral characteristics of the miners. METHODS: Through a case-control study, 125 miners working in Durango State, Mexico and 250 age- and gender-matched non-miner subjects were examined for the presence of anti-T...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829952/effect-of-l-carnitine-in-patients-with-liver-cirrhosis-on-energy-metabolism-using-indirect-calorimetry-a-pilot-study
#11
Yoshiyuki Sakai, Hiroki Nishikawa, Hirayuki Enomoto, Kazunori Yoh, Yoshinori Iwata, Kunihiro Hasegawa, Chikage Nakano, Kyohei Kishino, Yoshihiro Shimono, Ryo Takata, Takashi Nishimura, Nobuhiro Aizawa, Naoto Ikeda, Tomoyuki Takashima, Akio Ishii, Hiroko Iijima, Shuhei Nishiguchi
BACKGROUND: L-carnitine supplementation has been suggested to show several favorable effects on patients with liver cirrhosis (LC). However, there have been no reports regarding the effect of L-carnitine on energy metabolism in patients with LC using indirect calorimetry which is a well-established method for assessing the degree of liver malnutrition. We examined the effect of L-carnitine in patients with LC on energy metabolism using indirect calorimetry. METHODS: A total of 13 LC patients who are scheduled to be treated with L-carnitine (1,800 mg/day) were analyzed in this study...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829951/clinical-impact-of-blood-culture-results-in-acutely-ill-hospitalized-adult-patients-with-cystic-fibrosis
#12
Robert J Vender, Robert L Vender
BACKGROUND: Blood cultures are obtained clinically to confirm site and source of acute infection as well as to guide effective antibiotic therapies. Patients with cystic fibrosis (CF) are at risk for blood stream infection (BSI) as identified from positive blood culture results. METHODS: A retrospective chart review was performed of 190 adult CF patients from January 1, 2001 through December 1, 2015. All positive blood culture results were identified as to clinical relevance and source of BSI...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829950/effects-of-helicobacter-pylori-eradication-on-the-platelet-count-in-hepatitis-c-virus-infected-patients
#13
Tomoyuki Takashima, Hirayuki Enomoto, Yoshinori Iwata, Hiroki Nishikawa, Kazunori Yoh, Kunihiro Hasegawa, Chikage Nakano, Yukihisa Yuri, Noriko Ishii, Yuho Miyamoto, Ryo Takata, Takashi Nishimura, Akio Ishii, Yoshiyuki Sakai, Nobuhiro Aizawa, Naoto Ikeda, Hiroko Iijima, Shuhei Nishiguchi
BACKGROUND: Helicobacter pylori (H. pylori) infection is associated with a low platelet count in patients with immune thrombocytopenic purpura (ITP). While eradication of H. pylori is an established therapy for increasing the platelet count in ITP patients, it is unclear whether or not eradication will similarly affect the platelet counts in patients with chronic liver diseases (CLDs). We herein examined the effect of H. pylori eradication on the platelet counts in hepatitis C virus (HCV)-related CLD patients...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829949/exercise-intervention-for-anti-sarcopenia-in-community-dwelling-older-people
#14
REVIEW
Ryo Miyazaki, Taro Takeshima, Kazuhiko Kotani
Sarcopenia is an age-related health problem in general communities. Effective exercise programs against sarcopenia remain necessary for community-dwelling older people. In order to summarize the available knowledge on this subject, we collected English articles from a MEDLINE/Pubmed database examining the effects of exercise interventions on sarcopenia-related outcome measures in community-dwelling older people. When nine articles, including eight randomized controlled trials, were reviewed, most studies demonstrated significant improvements in some outcome measures...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829948/increased-hematocrit-during-sodium-glucose-cotransporter-2-inhibitor-therapy-indicates-recovery-of-tubulointerstitial-function-in-diabetic-kidneys
#15
REVIEW
Motoaki Sano, Makoto Takei, Yasuyuki Shiraishi, Yoshihiko Suzuki
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been attracting attention for cardiovascular as well as antidiabetic effects since the results of the Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients (EMPA-REG OUTCOME Trial) were reported. The hematocrit increases during treatment with SGLT2 inhibitors, which have a diuretic effect but do not cause sufficient hemoconcentration to increase the risk of cerebral infarction. Elevation of the hematocrit during SGLT2 inhibitor therapy is presumed to involve enhancement of erythropoiesis in addition to hemoconcentration...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27829947/why-physicians-should-look-at-the-mouths-of-their-patients
#16
EDITORIAL
Luciano Alberto de Castro, Joao Gabriel Leite de Castro, Jayanne Silva de Alcantara, Divino Alves Garcia Junior, Caio Santana Novaes Romeu, Itagores Hoffman Ii Lopes Sousa Coutinho
No abstract text is available yet for this article.
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27738487/effect-of-diet-on-serum-creatinine-in-healthy-subjects-during-a-phase-i-study
#17
Eduardo Pimenta, Markus Jensen, David Jung, Frank Schaumann, Stefanie Boxnick, Hubert Truebel
Creatinine is widely used as an indirect marker of renal function. However, interfering factors such as diet, exercise and problems with the assay can generate false results and misinterpretation of real kidney function. In this article, we report the dietary effects on serum creatinine during a phase I single dose escalation study and discuss the reasons why serum creatinine should be measured under fasting conditions.
November 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27738486/bacterial-pneumonia-caused-by-streptococcus-pyogenes-infection-a-case-report-and-review-of-the-literature
#18
Nobuhiro Akuzawa, Masahiko Kurabayashi
A 78-year-old Japanese man was admitted to our hospital because of fever lasting for 4 days. His white blood cell count and C-reactive protein level were elevated and computed tomography of the chest showed bronchopneumonia in the right upper lobe of the lung. Streptococcus pyogenes was detected from sputum and blood culture samples on admission and administration of ampicillin/sulbactam was effective. Although our patient's clinical course was good, S. pyogenes pneumonia commonly shows a high rate of fatality and septicemia, and may affect a previously healthy population...
November 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27738485/primary-b-cell-mucosa-associated-lymphoid-tissue-lymphoma-of-the-hard-palate-and-parotid-gland-report-of-one-case-and-review-of-the-literature
#19
Ipek Yonal-Hindilerden, Fehmi Hindilerden, Serkan Arslan, Nalan Turan-Guzel, Ibrahim Oner Dogan, Meliha Nalcaci
A 61-year-old woman was admitted to our hospital with an ulcerated palate mass and swelling of the right parotid gland. Incisional biopsy from the hard palate revealed an extranodal marginal zone B-cell lymphoma, also called mucosa-associated lymphoid tissue (MALT) lymphoma. Final diagnosis was MALT lymphoma of the parotid gland with concomitant involvement of an extremely seldom site of involvement: the hard palate. To our knowledge, this report illustrates the first case of MALT lymphoma of the hard palate and parotid gland without an underlying autoimmune disease...
November 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27738484/generalized-lymphadenopathy-as-presenting-feature-of-systemic-lupus-erythematosus-case-report-and-review-of-the-literature
#20
Wais Afzal, Talal Arab, Tofura Ullah, Katerina Teller, Kaushik J Doshi
Lymphadenopathy could represent a vast spectrum of etiologies including infectious and non-infectious diseases. Besides proper history taking, physical examination, and laboratory investigations, a tissue diagnosis is often necessary to unmask the cause of generalized lymphadenopathy. Here we present a 23-year-old woman who was admitted for diffuse generalized lymphadenopathy, fatigue, malaise, weight loss, nausea, and bilateral lower extremity edema. She reported a history of seizures as well as stroke 2 years prior with no other medical conditions present...
November 2016: Journal of Clinical Medicine Research
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