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International Journal of Inflammation

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https://www.readbyqxmd.com/read/30402217/familial-mediterranean-gene-mefv-mutation-in-parents-of-children-with-familial-mediterranean-fever-what-are-the-exceptions
#1
Leila Shahbaznejad, Sayed-Reza Raeeskarami, Raheleh Assari, Abbas Shakoori, Hamidreza Azhideh, Yahya Aghighi, Fatemeh Tahghighi, Vahid Ziaee
Objectives: Familial Mediterranean Fever (FMF) is one of the most prevalent periodic fever syndromes; MEFV, the responsible gene for the disease, is in the short arm of chromosome16. In the considerable count of the FMF patients, only one mutation is found in the MEFV and parents, who were the obligatory carriers for that mutation, were asymptomatic. The aim of this study was to evaluate these asymptomatic parents in regard to mutation in MEFV gene and similarity between parents and offspring patients...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/30245803/potential-pitfalls-of-the-humanized-mice-in-modeling-sepsis
#2
REVIEW
Krzysztof Laudanski, Michael Stentz, Matthew DiMeglio, William Furey, Toby Steinberg, Arpit Patel
Humanized mice are a state-of-the-art tool used to study several diseases, helping to close the gap between mice and human immunology. This review focuses on the potential obstacles in the analysis of immune system performance between humans and humanized mice in the context of severe acute inflammation as seen in sepsis or other critical care illnesses. The extent to which the reconstituted human immune system in mice adequately compares to the performance of the human immune system in human hosts is still an evolving question...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/30155241/association-of-elevated-serum-gm-csf-ifn-%C3%AE-il-4-and-tnf-%C3%AE-concentration-with-tobacco-smoke-induced-chronic-obstructive-pulmonary-disease-in-a-south-indian-population
#3
Ankita Mitra, Sangeetha Vishweswaraiah, Tania Ahalya Thimraj, Mahendra Maheswarappa, Chaya Sindaghatta Krishnarao, Komarla Sundararaja Lokesh, Jayaraj Biligere Siddaiah, Koustav Ganguly, Mahesh Padukudru Anand
Background: Chronic obstructive pulmonary disease (COPD) is a devastating condition with limited pharmacotherapeutic options and exceptionally high public-health burden globally as well as in India. Tobacco smoking is the primary cause for COPD among men in India. Systemic inflammation involving altered regulation of cytokines controlling the host defense mechanism is a hallmark of COPD pathogenesis. However, biomarker discovery studies are limited among Indian COPD patients. Methods: We assessed the serum concentrations [median (25th-75th percentile) pg/ml] of interleukin ( IL )-2,4,6,8,10, granulocyte macrophage colony stimulating factor ( GM-CSF ), interferon gamma ( IFN- γ ), and tumor necrosis factor alpha ( TNF- α ) using a multiplexed immunoassay...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/30112161/antipleuritic-and-vascular-permeability-inhibition-of-the-ethyl-acetate-petroleum-ether-stem-bark-extract-of-maerua-angolensis-dc-capparaceae-in-murine
#4
Felix Agyei Ampadu, Eric Boakye-Gyasi, Newman Osafo, Charles Kwaku Benneh, Edmund Ekuadzi, Eric Woode
Maerua angolensis has been used traditionally in the management of pain, arthritis, and rheumatism in Ghana and Nigeria but no scientific evidence is currently available to give credence to its folkloric use. The aim of this study was therefore to evaluate the anti-inflammatory effects of a stem bark extract of Maerua angolensis DC (MAE) in acute inflammatory models. The effects of MAE (30-300 mg kg-1 ) on neutrophil infiltration, exudate volume, and endogenous antioxidant enzymes in lung tissues and lung morphology were evaluated with the carrageenan induced pleurisy model in Sprague Dawley rats...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/30034774/a-cfa-induced-model-of-inflammatory-skin-disease-in-miniature-swine
#5
Nalú Navarro-Alvarez, Beatriz M M Gonçalves, Alec R Andrews, David H Sachs, Christene A Huang
Similarities between porcine and human skin make the pig an ideal model for preclinical studies of cutaneous inflammation and wound healing. Complete Freund's adjuvant (CFA) has been used to induce inflammation and to study inflammatory pain in several animal models. Here, we evaluated the inflammation caused by CFA injected in different layers of skin and subcutaneous (SC) tissue in a large-animal model. The degree of inflammation was evaluated at early and late time points by visual inspection and histopathologic analysis...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29805787/the-difference-in-interleukin-19-serum-on-degrees-of-acne-vulgaris-severity
#6
Moerbono Mochtar, Alamanda Murasmita, M Eko Irawanto, Indah Julianto, Harijono Kariosentono, Fajar Waskito
Introduction: Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris. Methods: This is an analytical observational cross-sectional study...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29692883/-s-equol-a-major-isoflavone-from-soybean-inhibits-nitric-oxide-production-in-lipopolysaccharide-stimulated-rat-astrocytes-partially-via-the-gpr30-mediated-pathway
#7
Mitsuaki Moriyama, Ayano Hashimoto, Hideyo Satoh, Kenji Kawabe, Mizue Ogawa, Katsura Takano, Yoichi Nakamura
Cumulative evidence indicates that estrogen receptor (ER) agonists attenuate neuroinflammation. Equol, a major isoflavone from soybean, exhibits estrogen-like biological activity, but their effect on inflammatory response has not been well established. Here, we investigated the effect of S -equol on nitric oxide (NO) production, well-known inflammatory change in astrocytes stimulated by LPS. S -Equol attenuated LPS-induced NO production with a concomitant decrease in expression of inducible NO synthase (iNOS)...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29686833/natural-products-with-toll-like-receptor-4-antagonist-activity
#8
REVIEW
Monica Molteni, Annalisa Bosi, Carlo Rossetti
Toll-Like Receptors (TLRs) are the innate immunity receptors that play an activating role when interacting with molecules released by bacteria and viruses (PAMPs, pathogen-associated molecular patterns) or with molecules released by injured cells and tissues (DAMPs, danger-associated molecular patterns). TLR triggering leads to the induction of proinflammatory cytokines and chemokines, driving the activation of both innate and adaptive immunity. In particular, Toll-Like Receptor 4 (TLR4) has been described to be involved in the inflammatory processes observed in several pathologies (such as ischemia/reperfusion injury, neuropathic pain, neurodegenerative diseases, and cancer)...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29568482/presenting-a-new-standard-drug-model-for-turmeric-and-its-prized-extract-curcumin
#9
REVIEW
Franco Cavaleri
Various parts of the turmeric plant have been used as medicinal treatment for various conditions from ulcers and arthritis to cardiovascular disease and neuroinflammation. The rhizome's curcumin extract is the most studied active constituent, which exhibits an expansive polypharmacology with influence on many key inflammatory markers. Despite the expansive reports of curcucmin's therapeutic value, clinical reliability and research repeatability with curcumin treatment are still poor. The pharmacology must be better understood and reliably mapped if curcumin is to be accepted and used in modern medical applications...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29568481/impaired-inflammatory-response-to-lps-in-type-2-diabetes-mellitus
#10
Lusine Khondkaryan, Sona Margaryan, David Poghosyan, Gayane Manukyan
Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels. High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients. The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNF α ( p < 0...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29348965/ethanol-induced-alterations-of-t-cells-and-cytokines-after-surgery-in-a-murine-infection-model
#11
Nadine Lanzke, Mario Menk, Clarissa von Haefen, Lilit Sargsyan, Bianca Scharf, Klaus-Dieter Wernecke, Claudia D Spies
Background: Interactions between alcohol, infection, and surgery and their effect on differentiation and functionality of T helper cells are not yet completely understood. We hypothesized that alcohol and surgery disturb differentiation of T helper cells and contribute to an impaired immune response. Methods: Mice were treated with alcohol for two weeks. Saline treatment served as control. Clinical performance and weight were assessed. On day 14, a median laparotomy was performed and animals were challenged with Klebsiella pneumoniae intranasally...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/29225991/administration-of-protein-kinase-d1-induces-a-protective-effect-on-lipopolysaccharide-induced-intestinal-inflammation-in-a-co-culture-model-of-intestinal-epithelial-caco-2-cells-and-raw264-7-macrophage-cells
#12
Ditte Søvsø Gundelund Nielsen, Marlene Fredborg, Vibeke Andersen, Stig Purup
Inflammatory bowel diseases (IBD) are chronic inflammatory diseases involving all or part of the gastrointestinal tract. The stress-activated serine-threonine protein kinase D1 (PKD1) protein has previously been implicated in intestinal immune regulation. The objective of this study was to evaluate the effects of human PKD1 in relation to intestinal inflammation, using a co-culture model of intestinal epithelial Caco-2 cells and RAW264.7 macrophages. An inflammatory response was induced in the macrophages by lipopolysaccharide (LPS), upregulating the expression of tumour necrosis factor alpha (TNF- α ), interleukin- (IL-) 1 β , and IL-6 besides increasing the secretion of TNF- α protein...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28828191/neutrophil-extracellular-trap-production-in-patients-with-colorectal-cancer-in-vitro
#13
J J R Richardson, C Hendrickse, F Gao-Smith, D R Thickett
PURPOSE: Neutrophil Extracellular Traps (NETs) are extracellular neutrophil derived DNA webs which have been implicated in cancer progression and in the development of metastases. NETs production in patients with colorectal cancer was investigated to elucidate their role and prognostic significance. METHODS: Systemic neutrophils were isolated from consecutive patients with colorectal cancer and from age-matched healthy volunteers. Neutrophils were stimulated to produce NETs which were quantified by a measure of the fluorescence of the extracellular DNA...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28811954/is-neutrophil-to-lymphocyte-ratio-a-predictor-of-coronary-artery-disease-in-western-indians
#14
Kamal Sharma, Alap K Patel, Komal H Shah, Ashwati Konat
INTRODUCTION: The current study was designed to evaluate the association of neutrophil-to-lymphocyte ratio (NLR) with coronary artery disease (CAD) presence. We also aimed to propose a suitable cut-off of NLR for diagnosis of CAD in Western Indians. METHODS: Total 324 patients undergoing coronary angiography were enrolled and were subdivided into two groups: group 1 (n = 99; population without CAD) and group 2 (n = 225; population with CAD). RESULTS: The results indicated significant (p < 0...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28811953/from-inflammation-to-current-and-alternative-therapies-involved-in-wound-healing
#15
REVIEW
Mariana Barreto Serra, Wermerson Assunção Barroso, Neemias Neves da Silva, Selma do Nascimento Silva, Antonio Carlos Romão Borges, Iracelle Carvalho Abreu, Marilene Oliveira da Rocha Borges
Wound healing is a complex event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. These phases are distinct in function and histological characteristics. However, they depend on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events. In this article, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28804668/impaired-mrna-expression-of-the-migration-related-chemokine-receptor-cxcr4-in-mesenchymal-stem-cells-of-copd-patients
#16
K Karagiannis, A Proklou, E Tsitoura, I Lasithiotaki, C Kalpadaki, D Moraitaki, I Sperelakis, G Kontakis, K M Antoniou, N Tzanakis
Defective tissue repair and remodeling are main aspects of Chronic Obstructive Pulmonary Disease (COPD) pathophysiology. Bone marrow mesenchymal stem cells (BM-MSCs) have been implicated in this direction, as their functional impairment and recruitment could possibly contribute to disease development and progression. The present study characterizes for the first time the expression of migration related chemokine receptors and their ligands in BM-MSCs from COPD patients. CXCR4/SDF1a and CCR7/CCL19-CCL21 mRNA levels were evaluated in BM-MSCs obtained from twelve COPD patients and seven healthy donors...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28676841/an-in-vitro-model-of-gastric-inflammation-and-treatment-with-cobalamin
#17
T R Elliott, A L Guildford
Pernicious anaemia (PA) is an autoimmune condition where antibodies target intrinsic factor and parietal cells, reducing the patient's ability to absorb cobalamin promoting atrophic gastritis. Treatment guidelines are based on excretion data of hydroxocobalamin from healthy individuals obtained 50 years ago. This manuscript describes the use of phorbol 12-myristate 13-acetate (PMA) to stimulate low grade inflammation in an epithelial colorectal cell line to assess the efficacy of methylcobalamin and hydroxocobalamin...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28660089/does-inhalation-of-virgin-coconut-oil-accelerate-reversal-of-airway-remodelling-in-an-allergic-model-of-asthma
#18
N A Kamalaldin, S A Sulaiman, M R Yusop, B Yahaya
Many studies have been done to evaluate the effect of various natural products in controlling asthma symptoms. Virgin coconut oil (VCO) is known to contain active compounds that have beneficial effects on human health and diseases. The objective of this study was to evaluate the effect of VCO inhalation on airway remodelling in a rabbit model of allergic asthma. The effects of VCO inhalation on infiltration of airway inflammatory cells, airway structures, goblet cell hyperplasia, and cell proliferation following ovalbumin induction were evaluated...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28660088/high-vitamin-d-levels-may-downregulate-inflammation-in-patients-with-beh%C3%A3-et-s-disease
#19
Fahd Adeeb, Maria Usman Khan, Xia Li, Austin G Stack, Joseph Devlin, Alexander D Fraser
Vitamin D plays a significant role in the immune system modulation and may confer a protective role in autoimmune diseases. We conducted a case-control study to compare 25(OH)D levels in patients with BD who were managed at a regional rheumatology programme in the midwest region of Ireland compared to matched controls. Healthy controls were selected from the Irish health system and matched in 1 : 5 ratio for age, sex, and the month of the year. 25(OH)D levels <20 nmol/L were classified as deficient while levels between 20 and 40 nmol/L were classified as insufficient...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28573063/alleviating-promotion-of-inflammation-and-cancer-induced-by-nonsteroidal-anti-inflammatory-drugs
#20
REVIEW
Anthony M Kyriakopoulos, Markus Nagl, Stella Baliou, Vasilleios Zoumpourlis
CLINICAL RELEVANCE: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays. These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition. Though beneficial for health in some instances, both unspecific and specific cyclooxygenase inhibitor activity interfere with AA metabolism producing also proinflammatory lipids that may promote cancer. MATERIALS AND METHODS: This review is based on available literature on clinical uses, biochemical investigations, molecular medicine, pharmacology, toxicity, and epidemiology-clinical studies on NSAIDs and other drugs that may be used accordingly, which was collected from electronic (SciFinder, Medline, Science Direct, and ACS among others) and library searches of books and journals...
2017: International Journal of Inflammation
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