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International Journal of Inflammation

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https://www.readbyqxmd.com/read/28421157/psoriatic-arthritis-is-an-indicator-of-significant-renal-damage-in-patients-with-psoriasis-an-observational-and-epidemiological-study
#1
Abidullah Khan, Iqbal Haider, Maimoona Ayub, Mohammad Humayun
Background. Psoriasis affects joints in around 30% of the patients. Recent studies have demonstrated an increased risk of essential hypertension, ischemic heart disease, and stroke in psoriatic patients. However, the prevalence of renal disease in patients with psoriasis has not been evaluated properly. Objectives. Objectives were to evaluate renal functions in patients with psoriasis and to assess any possible relationship of renal failure with psoriasis and psoriatic arthritis. Methods. In this cross-sectional study, 30 participants were recruited into the following three groups: group-A, psoriatic arthritis; group-B, psoriasis without arthritis; and group-C, healthy subjects...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28316860/hmgb1-and-histones-play-a-significant-role-in-inducing-systemic-inflammation-and-multiple-organ-dysfunctions-in-severe-acute-pancreatitis
#2
REVIEW
Runkuan Yang, Jyrki Tenhunen, Tor Inge Tonnessen
Severe acute pancreatitis (SAP) starts as a local inflammation of pancreatic tissue that induces the development of multiple extrapancreatic organs dysfunction; however, the underlying mechanisms are still not clear. Ischemia-reperfusion, circulating inflammatory cytokines, and possible bile cytokines significantly contribute to gut mucosal injury and intestinal bacterial translocation (BT) during SAP. Circulating HMGB1 level is significantly increased in SAP patients and HMGB1 is an important factor that mediates (at least partly) gut BT during SAP...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28127491/sterile-neuroinflammation-and-strategies-for-therapeutic-intervention
#3
REVIEW
Manoj Banjara, Chaitali Ghosh
Sterile neuroinflammation is essential for the proper brain development and tissue repair. However, uncontrolled neuroinflammation plays a major role in the pathogenesis of various disease processes. The endogenous intracellular molecules so called damage-associated molecular patterns or alarmins or damage signals that are released by activated or necrotic cells are thought to play a crucial role in initiating an immune response. Sterile inflammatory response that occurs in Alzheimer's disease (AD), Parkinson's disease (PD), stroke, hemorrhage, epilepsy, or traumatic brain injury (TBI) creates a vicious cycle of unrestrained inflammation, driving progressive neurodegeneration...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28116213/are-systematic-screening-for-vitamin-d-deficiency-and-vitamin-d-supplementation-currently-feasible-for-ankylosing-spondylitis-patients
#4
REVIEW
Mickael Essouma, Jean Jacques N Noubiap
Beyond its role in calcium and phosphorus metabolism for healthy bone mineralization, there is increasing awareness for vitamin D contribution in modulation of immune reactions. Given that ankylosing spondylitis (AS) is a chronic inflammatory disease involving excess immune/inflammatory activity and posing great therapeutic challenges, it is conceivable to claim that vitamin D treatment may be a safe and effective treatment to influence or modify the primary disease and its related comorbidities. Nevertheless, consistent body of research supporting this hypothesis is still lacking...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28116212/hyperexcitability-in-spinal-wdr-neurons-following-experimental-disc-herniation-is-associated-with-upregulation-of-fractalkine-and-its-receptor-in-nucleus-pulposus-and-the-dorsal-root-ganglion
#5
Daniel Pitz Jacobsen, Aurora Moen, Fred Haugen, Johannes Gjerstad
Introduction. Lumbar radicular pain following intervertebral disc herniation may be associated with a local inflammatory response induced by nucleus pulposus (NP) cells. Methods. In anaesthetized Lewis rats, extracellular single unit recordings of wide dynamic range (WDR) neurons in the dorsal horn and qPCR were used to explore the effect of NP application onto the dorsal nerve roots (L3-L5). Results. A clear increase in C-fiber response was observed following NP conditioning. In the NP tissue, the expression of interleukin-1β (IL-1β), colony stimulating factor 1 (Csf1), fractalkine (CX3CL1), and the fractalkine receptor CX3CR1 was increased...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/27795867/the-role-of-tlr2-tlr4-and-tlr9-in-the-pathogenesis-of-atherosclerosis
#6
REVIEW
Mohsin H K Roshan, Amos Tambo, Nikolai P Pace
Toll-like receptors (TLRs) are key players in the pathogenesis of inflammatory conditions including coronary arterial disease (CAD). They are expressed by a variety of immune cells where they recognize pathogen-associated molecular patterns (PAMPs). TLRs recruit adaptor molecules, including myeloid differentiation primary response protein (MYD88) and TIRF-related adaptor protein (TRAM), to mediate activation of MAPKs and NF-kappa B pathways. They are associated with the development of CAD through various mechanisms...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/27293953/inflammatory-serum-protein-profiling-of-patients-with-lumbar-radicular-pain-one-year-after-disc-herniation
#7
Aurora Moen, Anne-Li Lind, Måns Thulin, Masood Kamali-Moghaddam, Cecilie Røe, Johannes Gjerstad, Torsten Gordh
Earlier studies suggest that lumbar radicular pain following disc herniation may be associated with a local or systemic inflammatory process. In the present study, we investigated the serum inflammatory protein profile of such patients. All 45 patients were recruited from Oslo University Hospital, Ullevål, Norway, during the period 2007-2009. The new multiplex proximity extension assay (PEA) technology was used to analyze the levels of 92 proteins. Interestingly, the present data showed that patients with radicular pain 12 months after disc herniation may be different from other patients with regard to many measurable serum cytokines...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/26998377/the-effect-of-periodontitis-on-expression-of-interleukin-21-a-systematic-review
#8
REVIEW
Archana Mootha, Sankari Malaiappan, N D Jayakumar, Sheeja S Varghese, Julie Toby Thomas
Purpose. Inflammation and tissue breakdown are led by an array of inflammatory destructive mediators associated with initiation and progression of inflammatory diseases like periodontitis. Current evidence shows that these inflammatory mediators have a definitive role in the pathogenesis of various systemic diseases with an inflammatory component. Interleukin-21 (IL-21) has been associated with systemic diseases like rheumatoid arthritis and Crohn's disease that follow a chronic inflammatory cascade. Similarly recent studies have associated Interleukin-21 levels with periodontitis...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/26981311/association-of-alanine-aminotransferase-and-periodontitis-a-cross-sectional-analysis-nhanes-2009-2012
#9
R Constance Wiener, Usha Sambamoorthi, Richard J Jurevic
Objective. Alanine Aminotransferase is an enzyme associated with not only liver diseases, liver conditions, and metabolic syndrome, but also inflammation. Periodontitis is associated with increased cytokines and other markers of inflammation. The purpose of this study is to determine if an independent association between Alanine Aminotransferase and periodontitis exists. Methods. Data from the 2009-2010 and 2011-2012 National Health and Nutrition Surveys (NHANES) were combined. Data concerning periodontitis and Alanine Aminotransferase were extracted and analyzed with Rao Scott Chi-square and logistic regressions...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/26966610/the-pattern-of-juvenile-idiopathic-arthritis-in-a-single-tertiary-center-in-saudi-arabia
#10
Mohammad H Al-Hemairi, Shatha M Albokhari, Mohammed A Muzaffer
Introduction. Juvenile Idiopathic Arthritis (JIA) is the most common chronic arthritis in children. Our aim is to describe demographic, clinical, and laboratory characteristics and treatment of JIA patients followed up in Pediatric Rheumatology clinic in a tertiary center in Saudi Arabia. Methods. Medical records of all patients who are followed up between January 2007 and January 2015 were retrospectively reviewed. Data were collected about demographic, clinical, and laboratory features and treatment. Results...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/26925290/investigation-of-the-anti-inflammatory-and-analgesic-activities-of-ethanol-extract-of-stem-bark-of-sonapatha-oroxylum-indicum-in-vivo
#11
K Lalrinzuali, M Vabeiryureilai, Ganesh Chandra Jagetia
Inflammation is all a pervasive phenomenon, which is elicited by the body in response to obnoxious stimuli as a protective measure. However, sustained inflammation leads to several diseases including cancer. Therefore it is necessary to neutralize inflammation. Sonapatha (Oroxylum indicum), a medicinal plant, is traditionally used as a medicine in Ayurveda and other folk systems of medicine. It is commonly used to treat inflammatory diseases including rheumatoid arthritis and asthma. Despite this fact its anti-inflammatory and analgesic effects are not evaluated scientifically...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/26885437/intravenous-immunoglobulins-mode-of-action-and-indications-in-autoimmune-and-inflammatory-dermatoses
#12
REVIEW
Lyubomir A Dourmishev, Dimitrina V Guleva, Ljubka G Miteva
Intravenous immunoglobulins (IVIGs), a mixture of variable amounts of proteins (albumin, IgG, IgM, IgA, and IgE antibodies), as well as salt, sugar, solvents, and detergents, are successfully used to treat a variety of dermatological disorders. For decades, IVIGs have been administered for treatment of infectious diseases and immune deficiencies, since they contain natural antibodies that represent a first-line defense against pathogens. Today their indication has expanded, including the off-label therapy for a variety of autoimmune and inflammatory diseases...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/26881175/nicotine-inhibits-clostridium-difficile-toxin-a-induced-colitis-but-not-ileitis-in-rats
#13
Steven R Vigna
Nicotine is protective in ulcerative colitis but not Crohn's disease of the small intestine, but little is known about the effects of nicotine on Clostridium difficile toxin A-induced enteritis. Isolated ileal or colonic segments in anesthetized rats were pretreated with nicotine bitartrate or other pharmacological agents before intraluminal injection of toxin A. After 3 hours, the treated segments were removed and inflammation was assessed. Nicotine biphasically inhibited toxin A colitis but not ileitis. Pretreatment with the nicotinic receptor antagonist, hexamethonium, blocked the effects of nicotine...
2016: International Journal of Inflammation
https://www.readbyqxmd.com/read/26881174/eola1-inhibits-lipopolysaccharide-induced-vascular-cell-adhesion-molecule-1-expression-by-association-with-mt2a-in-ecv304-cells
#14
Weiling Leng, Xiaotian Lei, Hao Meng, Xinshou Ouyang, Ziwen Liang
Our research group firstly discovered endothelial-overexpressed lipopolysaccharide-associated factor 1 (EOLA1, GenBank number AY074889) as a lipopolysaccharide (LPS) responsive gene in ECV304 cells. The previous studies have further demonstrated the association of EOLA1 with metallothionein 2A (MT2A), while the role of EOLA1 during LPS-induced inflammatory response in ECV304 cells is unknown. In this report, we determined the subcellular localization of EOLA1 and the regulatory capacity of EOLA1 on vascular cell adhesion molecule-1 (VCAM-1) in response to LPS in ECV304 cells...
2015: International Journal of Inflammation
https://www.readbyqxmd.com/read/26839731/angiogenesis-in-inflammatory-bowel-disease
#15
REVIEW
Canan Alkim, Huseyin Alkim, Ali Riza Koksal, Salih Boga, Ilker Sen
Angiogenesis is an important component of pathogenesis of inflammatory bowel disease (IBD). Chronic inflammation and angiogenesis are two closely related processes. Chronic intestinal inflammation is dependent on angiogenesis and this angiogenesis is modulated by immune system in IBD. Angiogenesis is a very complex process which includes multiple cell types, growth factors, cytokines, adhesion molecules, and signal transduction. Lymphangiogenesis is a new research area in the pathogenesis of IBD. While angiogenesis supports inflammation via leukocyte migration, carrying oxygen and nutrients, on the other hand, it has a major role in wound healing...
2015: International Journal of Inflammation
https://www.readbyqxmd.com/read/26798546/vegfr-2-expression-in-glioblastoma-multiforme-depends-on-inflammatory-tumor-microenvironment
#16
Jana Jaal, Marju Kase, Ave Minajeva, Mikk Saretok, Aidi Adamson, Jelizaveta Junninen, Tõnis Metsaots, Tõnu Jõgi, Madis Joonsalu, Markus Vardja, Toomas Asser
Glioblastoma multiforme (GBM) is one of the most angiogenic tumors. However, antiangiogenic therapy has not shown significant clinical efficacy. The aim of our study was to evaluate the impact of inflammatory tumor microenvironment on the expression of vascular endothelial growth factor receptor 2 (VEGFR-2). Surgically excised primary GBM tissues were histologically examined for overall extent of inflammation (score 1-3). After immunohistochemistry, the tissue expression of ICAM-1 (optical density), the number of VEGFR-2 positive (VEGFR-2+) blood vessels (per microscopic field), and the endothelial staining intensity of VEGFR-2 (score 0-3) were determined...
2015: International Journal of Inflammation
https://www.readbyqxmd.com/read/26770865/ccr7-receptor-expression-in-mono-mac-1-cells-modulation-by-liver-x-receptor-%C3%AE-activation-and-prostaglandin-e-2
#17
Bérengère Tanné, Stéphane Bernier, Nancy Dumais
Cell migration via chemokine receptor CCR7 expression is an essential function of the immune system. We previously showed that prostaglandin E2 (PGE2), an important immunomodulatory molecule, increases CCR7 expression and function in monocytes. Here, we explore the role of the liver X receptor α (LXRα) activation on CCR7 expression in Mono-Mac-1 (MM-1) cells in the presence of PGE2. To do this, MM-1 cells were stimulated with the LXRα synthetic agonist T0901317 in the presence or absence of PGE2. CCR7 mRNA transcription was measured using quantitative RT-PCR and protein expression was examined using flow cytometry...
2015: International Journal of Inflammation
https://www.readbyqxmd.com/read/26550518/curbing-inflammation-in-multiple-sclerosis-and-endometriosis-should-mast-cells-be-targeted
#18
REVIEW
David A Hart
Inflammatory diseases and conditions can arise due to responses to a variety of external and internal stimuli. They can occur acutely in response to some stimuli and then become chronic leading to tissue damage and loss of function. While a number of cell types can be involved, mast cells are often present and can be involved in the acute and chronic processes. Recent studies in porcine and rabbit models have supported the concept of a central role for mast cells in a "nerve-mast cell-myofibroblast axis" in some inflammatory processes leading to fibrogenic outcomes...
2015: International Journal of Inflammation
https://www.readbyqxmd.com/read/26457222/lipopolysaccharide-from-rhodobacter-sphaeroides-attenuates-microglia-mediated-inflammation-and-phagocytosis-and-directs-regulatory-t-cell-response
#19
Sagar Gaikwad, Reena Agrawal-Rajput
Microglia activation and neuroinflammation are key events during the progression of neurodegenerative disorders. Microglia exhibits toll-like receptors (TLRs), with predominant expression of TLR4, inducing aberrant neuroinflammation and exacerbated neurotoxicity. Studies suggest that microglia initiate infiltration of T cells into the brain that critically influence disease conditions. We report that LPS-Rs, through TLR4 antagonism, significantly inhibit TLR4 mediated inflammatory molecules like IL-1β, IL-6, TNF-α, COX-2, iNOS, and NO...
2015: International Journal of Inflammation
https://www.readbyqxmd.com/read/26366318/smoking-status-effect-on-inflammatory-markers-in-a-randomized-trial-of-current-and-former-heavy-smokers
#20
Sami Aldaham, Janet A Foote, H-H Sherry Chow, Iman A Hakim
Background. The level of systemic inflammation as measured by circulating levels of C-reactive protein (CRP) and interleukin-6 (IL-6) is linked to an increased risk for cardiovascular diseases (CVD) and cancer. Methods. We recruited 154 current and former smokers between 40 and 80 years of age with 25 or more pack-years of smoking history to study the relationship between inflammatory markers (CRP and IL-6) and smoking status. Results. Our results show that male smokers had significantly higher levels of serum IL-6 compared to male former smokers...
2015: International Journal of Inflammation
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