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International Journal of Inflammation

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https://www.readbyqxmd.com/read/29692883/-s-equol-a-major-isoflavone-from-soybean-inhibits-nitric-oxide-production-in-lipopolysaccharide-stimulated-rat-astrocytes-partially-via-the-gpr30-mediated-pathway
#1
Mitsuaki Moriyama, Ayano Hashimoto, Hideyo Satoh, Kenji Kawabe, Mizue Ogawa, Katsura Takano, Yoichi Nakamura
Cumulative evidence indicates that estrogen receptor (ER) agonists attenuate neuroinflammation. Equol, a major isoflavone from soybean, exhibits estrogen-like biological activity, but their effect on inflammatory response has not been well established. Here, we investigated the effect of S -equol on nitric oxide (NO) production, well-known inflammatory change in astrocytes stimulated by LPS. S -Equol attenuated LPS-induced NO production with a concomitant decrease in expression of inducible NO synthase (iNOS)...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29686833/natural-products-with-toll-like-receptor-4-antagonist-activity
#2
REVIEW
Monica Molteni, Annalisa Bosi, Carlo Rossetti
Toll-Like Receptors (TLRs) are the innate immunity receptors that play an activating role when interacting with molecules released by bacteria and viruses (PAMPs, pathogen-associated molecular patterns) or with molecules released by injured cells and tissues (DAMPs, danger-associated molecular patterns). TLR triggering leads to the induction of proinflammatory cytokines and chemokines, driving the activation of both innate and adaptive immunity. In particular, Toll-Like Receptor 4 (TLR4) has been described to be involved in the inflammatory processes observed in several pathologies (such as ischemia/reperfusion injury, neuropathic pain, neurodegenerative diseases, and cancer)...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29568482/presenting-a-new-standard-drug-model-for-turmeric-and-its-prized-extract-curcumin
#3
REVIEW
Franco Cavaleri
Various parts of the turmeric plant have been used as medicinal treatment for various conditions from ulcers and arthritis to cardiovascular disease and neuroinflammation. The rhizome's curcumin extract is the most studied active constituent, which exhibits an expansive polypharmacology with influence on many key inflammatory markers. Despite the expansive reports of curcucmin's therapeutic value, clinical reliability and research repeatability with curcumin treatment are still poor. The pharmacology must be better understood and reliably mapped if curcumin is to be accepted and used in modern medical applications...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29568481/impaired-inflammatory-response-to-lps-in-type-2-diabetes-mellitus
#4
Lusine Khondkaryan, Sona Margaryan, David Poghosyan, Gayane Manukyan
Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels. High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients. The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNF α ( p < 0...
2018: International Journal of Inflammation
https://www.readbyqxmd.com/read/29348965/ethanol-induced-alterations-of-t-cells-and-cytokines-after-surgery-in-a-murine-infection-model
#5
Nadine Lanzke, Mario Menk, Clarissa von Haefen, Lilit Sargsyan, Bianca Scharf, Klaus-Dieter Wernecke, Claudia D Spies
Background: Interactions between alcohol, infection, and surgery and their effect on differentiation and functionality of T helper cells are not yet completely understood. We hypothesized that alcohol and surgery disturb differentiation of T helper cells and contribute to an impaired immune response. Methods: Mice were treated with alcohol for two weeks. Saline treatment served as control. Clinical performance and weight were assessed. On day 14, a median laparotomy was performed and animals were challenged with Klebsiella pneumoniae intranasally...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/29225991/administration-of-protein-kinase-d1-induces-a-protective-effect-on-lipopolysaccharide-induced-intestinal-inflammation-in-a-co-culture-model-of-intestinal-epithelial-caco-2-cells-and-raw264-7-macrophage-cells
#6
Ditte Søvsø Gundelund Nielsen, Marlene Fredborg, Vibeke Andersen, Stig Purup
Inflammatory bowel diseases (IBD) are chronic inflammatory diseases involving all or part of the gastrointestinal tract. The stress-activated serine-threonine protein kinase D1 (PKD1) protein has previously been implicated in intestinal immune regulation. The objective of this study was to evaluate the effects of human PKD1 in relation to intestinal inflammation, using a co-culture model of intestinal epithelial Caco-2 cells and RAW264.7 macrophages. An inflammatory response was induced in the macrophages by lipopolysaccharide (LPS), upregulating the expression of tumour necrosis factor alpha (TNF- α ), interleukin- (IL-) 1 β , and IL-6 besides increasing the secretion of TNF- α protein...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28828191/neutrophil-extracellular-trap-production-in-patients-with-colorectal-cancer-in-vitro
#7
J J R Richardson, C Hendrickse, F Gao-Smith, D R Thickett
PURPOSE: Neutrophil Extracellular Traps (NETs) are extracellular neutrophil derived DNA webs which have been implicated in cancer progression and in the development of metastases. NETs production in patients with colorectal cancer was investigated to elucidate their role and prognostic significance. METHODS: Systemic neutrophils were isolated from consecutive patients with colorectal cancer and from age-matched healthy volunteers. Neutrophils were stimulated to produce NETs which were quantified by a measure of the fluorescence of the extracellular DNA...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28811954/is-neutrophil-to-lymphocyte-ratio-a-predictor-of-coronary-artery-disease-in-western-indians
#8
Kamal Sharma, Alap K Patel, Komal H Shah, Ashwati Konat
INTRODUCTION: The current study was designed to evaluate the association of neutrophil-to-lymphocyte ratio (NLR) with coronary artery disease (CAD) presence. We also aimed to propose a suitable cut-off of NLR for diagnosis of CAD in Western Indians. METHODS: Total 324 patients undergoing coronary angiography were enrolled and were subdivided into two groups: group 1 (n = 99; population without CAD) and group 2 (n = 225; population with CAD). RESULTS: The results indicated significant (p < 0...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28811953/from-inflammation-to-current-and-alternative-therapies-involved-in-wound-healing
#9
REVIEW
Mariana Barreto Serra, Wermerson Assunção Barroso, Neemias Neves da Silva, Selma do Nascimento Silva, Antonio Carlos Romão Borges, Iracelle Carvalho Abreu, Marilene Oliveira da Rocha Borges
Wound healing is a complex event that develops in three overlapping phases: inflammatory, proliferative, and remodeling. These phases are distinct in function and histological characteristics. However, they depend on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events. In this article, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28804668/impaired-mrna-expression-of-the-migration-related-chemokine-receptor-cxcr4-in-mesenchymal-stem-cells-of-copd-patients
#10
K Karagiannis, A Proklou, E Tsitoura, I Lasithiotaki, C Kalpadaki, D Moraitaki, I Sperelakis, G Kontakis, K M Antoniou, N Tzanakis
Defective tissue repair and remodeling are main aspects of Chronic Obstructive Pulmonary Disease (COPD) pathophysiology. Bone marrow mesenchymal stem cells (BM-MSCs) have been implicated in this direction, as their functional impairment and recruitment could possibly contribute to disease development and progression. The present study characterizes for the first time the expression of migration related chemokine receptors and their ligands in BM-MSCs from COPD patients. CXCR4/SDF1a and CCR7/CCL19-CCL21 mRNA levels were evaluated in BM-MSCs obtained from twelve COPD patients and seven healthy donors...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28676841/an-in-vitro-model-of-gastric-inflammation-and-treatment-with-cobalamin
#11
T R Elliott, A L Guildford
Pernicious anaemia (PA) is an autoimmune condition where antibodies target intrinsic factor and parietal cells, reducing the patient's ability to absorb cobalamin promoting atrophic gastritis. Treatment guidelines are based on excretion data of hydroxocobalamin from healthy individuals obtained 50 years ago. This manuscript describes the use of phorbol 12-myristate 13-acetate (PMA) to stimulate low grade inflammation in an epithelial colorectal cell line to assess the efficacy of methylcobalamin and hydroxocobalamin...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28660089/does-inhalation-of-virgin-coconut-oil-accelerate-reversal-of-airway-remodelling-in-an-allergic-model-of-asthma
#12
N A Kamalaldin, S A Sulaiman, M R Yusop, B Yahaya
Many studies have been done to evaluate the effect of various natural products in controlling asthma symptoms. Virgin coconut oil (VCO) is known to contain active compounds that have beneficial effects on human health and diseases. The objective of this study was to evaluate the effect of VCO inhalation on airway remodelling in a rabbit model of allergic asthma. The effects of VCO inhalation on infiltration of airway inflammatory cells, airway structures, goblet cell hyperplasia, and cell proliferation following ovalbumin induction were evaluated...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28660088/high-vitamin-d-levels-may-downregulate-inflammation-in-patients-with-beh%C3%A3-et-s-disease
#13
Fahd Adeeb, Maria Usman Khan, Xia Li, Austin G Stack, Joseph Devlin, Alexander D Fraser
Vitamin D plays a significant role in the immune system modulation and may confer a protective role in autoimmune diseases. We conducted a case-control study to compare 25(OH)D levels in patients with BD who were managed at a regional rheumatology programme in the midwest region of Ireland compared to matched controls. Healthy controls were selected from the Irish health system and matched in 1 : 5 ratio for age, sex, and the month of the year. 25(OH)D levels <20 nmol/L were classified as deficient while levels between 20 and 40 nmol/L were classified as insufficient...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28573063/alleviating-promotion-of-inflammation-and-cancer-induced-by-nonsteroidal-anti-inflammatory-drugs
#14
REVIEW
Anthony M Kyriakopoulos, Markus Nagl, Stella Baliou, Vasilleios Zoumpourlis
CLINICAL RELEVANCE: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays. These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition. Though beneficial for health in some instances, both unspecific and specific cyclooxygenase inhibitor activity interfere with AA metabolism producing also proinflammatory lipids that may promote cancer. MATERIALS AND METHODS: This review is based on available literature on clinical uses, biochemical investigations, molecular medicine, pharmacology, toxicity, and epidemiology-clinical studies on NSAIDs and other drugs that may be used accordingly, which was collected from electronic (SciFinder, Medline, Science Direct, and ACS among others) and library searches of books and journals...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28553556/the-role-of-toll-like-receptors-in-autoimmune-diseases-through-failure-of-the-self-recognition-mechanism
#15
REVIEW
Mark Farrugia, Byron Baron
Toll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. However, when specific cellular contexts develop in which TLRs are inappropriately activated by self-components, this may lead to sterile inflammation and result in the occurrence of autoimmunity. This review analyses the available data regarding TLR biochemistry, the specific mechanisms which are brought about by TLR activation, and the importance of these mechanisms in the light of any existing and potential therapies in the field of autoimmunity...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28523203/mycobacterium-avium-subsp-paratuberculosis-induces-specific-ige-production-in-japanese-people-with-allergies
#16
D Cossu, S Otsubo, Y Otsubo, S Eda, T Suzuki, Y Iwao, T Kuribayashi, S Yamamoto, L A Sechi, E Momotani
Background. The prevalence of allergies is steadily increasing worldwide; however, the pathogenesis is still unclear. We hypothesized that Mycobacterium avium subsp. paratuberculosis (MAP) may contribute to allergy development. This organism can be present in dairy foods, it can elicit an immunomodulatory switch from a Th1 to a Th2 response, and it has been speculated that it is linked to several human autoimmune diseases. To determine the contribution, sera from 99 individuals with various atopic disorders and 45 healthy nonallergic controls were assessed for total IgE levels and successively for MAP-specific IgE by ELISA...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28523202/identification-of-a-novel-alternatively-spliced-form-of-inflammatory-regulator-swap-70-like-adapter-of-t-cells
#17
Marie Hashimoto, Jun-Ichi Nagao, Shojiro Ikezaki, Sonoko Tasaki, Ken-Ichi Arita-Morioka, Yuka Narita, Tamaki Cho, Kenji Yuasa, Amnon Altman, Yoshihiko Tanaka
Activation of naive CD4(+) T cells results in the development of several distinct subsets of effector Th cells, including Th2 cells that play a pivotal role in allergic inflammation and helminthic infections. SWAP-70-like adapter of T cells (SLAT), also known as Def6 or IBP, is a guanine nucleotide exchange factor for small GTPases, which regulates CD4(+) T cell inflammatory responses by controlling Ca(2+)/NFAT signaling. In this study, we have identified a novel alternatively spliced isoform of SLAT, named SLAT2, which lacks the region encoded by exons 2-7 of the Def6 gene...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28487813/transcriptional-and-molecular-pathways-activated-in-mesenteric-adipose-tissue-and-intestinal-mucosa-of-crohn-s-disease-patients
#18
Andressa Coope, Lívia Bitencourt Pascoal, Francesca Aparecida Ramos da Silva, José Diego Botezelli, Maria de Lourdes Setsuko Ayrizono, Marciane Milanski, Michel Gardere Camargo, Núria Planell, Mariana Portovedo, Cilene Bicca Dias, João José Fagundes, Raquel Franco Leal
Crohn's disease (CD) is a chronic inflammatory disorder, characterized by cytokine imbalance and transcription signaling pathways activation. In addition, the increase of mesenteric adipose tissue (MAT) near the affected intestinal area is a hallmark of CD. Therefore, we evaluated the transcription signaling pathways and cytokines expression in intestinal mucosa and MAT of active CD patients. Ten patients with ileocecal CD and eight with noninflammatory diseases were studied. The biopsies of intestinal mucosa and MAT were snap-frozen and protein expression was determined by immunoblotting...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28487812/high-sensitive-c-reactive-protein-levels-in-a-group-of-syrian-university-male-students-and-its-associations-with-smoking-physical-activity-anthropometric-measurements-and-some-hematologic-inflammation-biomarkers
#19
Wafika Zarzour, Nada Dehneh, Mazen Rajab
In Syria, health risk data on young males are limited. Hence, the aim of the present study was to evaluate cardiovascular disease (CVD) risk factors along with C-reactive protein levels measured by high-sensitive method (hsCRP) in a group of healthy males of university students (n = 101, 18-25 years old). Participants' anthropometric characteristics; alcohol drinking, smoking, and physical activity habits; parents medical history; and some inflammatory biomarkers were inspected for their associations with hsCRP...
2017: International Journal of Inflammation
https://www.readbyqxmd.com/read/28487811/curcumin-inhibits-nthi-induced-muc5ac-mucin-overproduction-in-otitis-media-via-upregulation-of-mapk-phosphatase-mkp-1
#20
Anuhya Sharma Konduru, Shingo Matsuyama, Byung-Cheol Lee, Kensei Komatsu, Jian-Dong Li
Otitis media (OM), characterized by the presence of mucus overproduction and excess inflammation in the middle ear, is the most common childhood infection. Nontypeable Haemophilus influenzae (NTHi) pathogen is responsible for approximately one-third of episodes of bacteria-caused OM. Current treatments for bacterial OM rely on the systemic use of antibiotics, which often leads to the emergence of multidrug resistant bacterial strains. Therefore there is an urgent need for developing alternative therapies strategies for controlling mucus overproduction in OM...
2017: International Journal of Inflammation
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