journal
MENU ▼
Read by QxMD icon Read
search

Journal of Advanced Pharmaceutical Technology & Research

journal
https://www.readbyqxmd.com/read/27833897/anticancer-antioxidant-potential-and-profiling-of-polyphenolic-compounds-of-wrightia-tinctoria-roxb-r-br-bark
#1
Nishat Fatima, Mohammad Kaleem Ahmad, Jamal Akhtar Ansari, Zulfiqar Ali, Abdul Rahman Khan, Abbas Ali Mahdi
Wrightia tinctoria Roxb. (R.Br.) is an Ayurvedic remedy, ethnomedically used in the treatment of various ailments. The present work was carried out to evaluate the anticancer and antioxidant activity as well as total phenolic and phytochemical contents of W. tinctoria bark methanolic extract (WTBM) by high-performance liquid chromatography (HPLC)-diode array detector. Antiproliferative activity of WTBM was evaluated against MDA-MB-231 and MCF-7 cancer cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation, and Hoechst staining...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833896/isolation-and-characterization-of-quinine-from-polygonatum-verticillatum-a-new-marker-approach-to-identify-substitution-and-adulteration
#2
Jaswinder Kaur Virk, Sanjiv Kumar, Ranjit Singh, Avinash C Tripathi, Shailendra K Saraf, Vikas Gupta, Parveen Bansal
Polygonatum verticillatum (Mahameda) is an important ingredient of Ashtawarga and Ayurvedic formulations. Nowadays, it comes under the category of endangered plants due to large scale and indiscriminate collection of wild material. To overcome the scarcity, substitutes of Mahameda are also commonly used in market. These additives are different from the authentic plant by Ayurvedic and pharmacological theory of drug action, thereby resulting in substitution/adulteration. Substitution is a critical issue in isolation and quantification of the therapeutically active ingredients that can be used as markers in the identification of substitution/adulteration...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833895/evaluation-of-antibacterial-activity-of-achyranthes-aspera-extract-against-streptococcus-mutans-an-in-vitro-study
#3
Roma Yadav, Radhika Rai, Abhishek Yadav, Meetika Pahuja, Savita Solanki, Himani Yadav
Dental caries and periodontal diseases have historically been considered the most important global oral health burdens. Many chemicals and synthetic drugs have marked the side effects. Hence, there has been a paradigm shift from the use of modern drugs to the age-old herbs. Achyranthes aspera is one such important plant with various established pharmaceutical properties. The aim of this study was to assess the antibacterial activity of the A. aspera extract against Streptococcus mutans. Aqueous extract of A...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833894/comparison-of-the-effects-of-methylphenidate-and-the-combination-of-methylphenidate-and-risperidone-in-preschool-children-with-attention-deficit-hyperactivity-disorder
#4
Parvin Safavi, Ali Hasanpour Dehkordi, Nasim Ghasemi
Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric disorder among preschool children but the number of controlled clinical trials regarding psychopharmacological treatment in this age group is limited. The aim of this study was to compare methylphenidate with the combination of methylphenidate and risperidone in preschool children with ADHD. Forty-two preschool children, aged 3-6 years, diagnosed with ADHD by a child and adolescent psychiatrist according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-Text Revision criteria, were enrolled in a 6-week, single-blind clinical trial and administered with methylphenidate (5-30 mg/dl) or the combination of methylphenidate and risperidone (0...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833893/thermoreversible-gel-for-intrapocket-delivery-of-green-tea-catechin-as-a-local-drug-delivery-system-an-original-research
#5
M Yuvaraja, N Raghavendra Reddy, P Mohan Kumar, K S Ravi, Nabeeh Alqahtani
The periodontal therapies along with systemic antibiotic therapy aim at eliminating the subgingival microbiota to arrest the progression of periodontal diseases. The complete elimination is often difficult, and thus the probability of repopulation after periodontal therapy is also high. The objectives of the study are to develop in situ thermoreversible gelling system of green tea catechins suitable for periodontal pocket administration, which would act as an adjunct to mechanical periodontal therapy. Gel is prepared on a weight basis using a cold process...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833892/pharmacognostic-specification-of-zanthoxylum-limonella-dennst-alston-fruits-and-seeds-in-thailand
#6
Rawiwan Charoensup, Thidarat Duangyod, Pravaree Phuneerub, Chatubhong Singharachai
Zanthoxylum limonella (Dennst.) Alston. (Rutaceae) or Ma-khwaen is one of the medicinal plants in Thai traditional medicine. To investigate the pharmacognostic specifications and chemical constituents of Z. limonella fruits and seeds. Fruits and seeds of Z. limonella were collected from 15 sources throughout Thailand; then examined the pharmacognostic specification following WHO guideline of quality control method for medicinal plant materials. Microscopic determination of Z. limonella powders demonstrated fragment of mesocarp, fragment of brown vitta, oil glands, fragment of endocarp, and endosperm containing oil globule, trichome and pale brown stone cells...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833891/characterization-of-mangifera-indica-cultivars-in-thailand-based-on-macroscopic-microscopic-and-genetic-characters
#7
Aunyachulee Ganogpichayagrai, Kanchana Rungsihirunrat, Chanida Palanuvej, Nijsiri Ruangrungsi
Thai mango cultivars are classified into six groups plus one miscellaneous group according to germplasm database for mango. Characterization is important for conservation and the development of Thai mango cultivars. This study investigated macroscopic, microscopic leaf characteristics, and genetic relationship among 17 cultivars selected from six groups of mango in Thailand. Selected mango samples were obtained from three different locations in Thailand (n = 57). They were observed for their leaf and fruit macroscopic characteristics...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833890/neuroanatomical-changes-in-parkinson-s-disease-in-relation-to-cognition-an-update
#8
REVIEW
K G Prakash, B M Bannur, Madhavrao D Chavan, K Saniya, Kumar Sai Sailesh, Archana Rajagopalan
The pathophysiological changes underlying impairment of cognition in Parkinson's disease (PD) are complex and not fully understood till date. Hence, understanding the structural changes responsible for cognitive decline in PD is essential for early diagnosis and to offer effective treatment. In this review, we discuss the neuroanatomical changes in major brain structures responsible for cognition in PD. We have included the key findings of various studies to provide up-to-date information for better understanding of pathophysiology of PD, which will help researchers and clinicians in planning and developing new treatment methods for the benefit of PD patients...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833889/interim-analysis-a-rational-approach-of-decision-making-in-clinical-trial
#9
REVIEW
Amal Kumar, Bhaswat S Chakraborty
Interim analysis of especially sizeable trials keeps the decision process free of conflict of interest while considering cost, resources, and meaningfulness of the project. Whenever necessary, such interim analysis can also call for potential termination or appropriate modification in sample size, study design, and even an early declaration of success. Given the extraordinary size and complexity today, this rational approach helps to analyze and predict the outcomes of a clinical trial that incorporate what is learned during the course of a study or a clinical development program...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833888/deformable-vesicles-alternatives-in-topical-drug-delivery
#10
EDITORIAL
Upendra Nagaich
No abstract text is available yet for this article.
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429932/retraction-case-report-and-clinical-databased-research-study-on-malaria
#11
(no author information available yet)
[This retracts the article on p. 18 in vol. 1, PMID: 22247827.].
July 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429931/evaluating-bionanoparticle-infused-fungal-metabolites-as-a-novel-antimicrobial-agent
#12
Kartikeya Rajpal, Nafe Aziz, Ram Prasad, Ramendra G Varma, Ajit Varma
Therapeutic properties of fungal metabolites and silver nanoparticles have been well documented. While fungal metabolites have been used for centuries as medicinal drugs, potential of biogenic silver nanoparticles has recently received attention. We have evaluated the antimicrobial potential of Aspergillus terreus crude extract, silver nanoparticles and an amalgamation of both against four pathogenic bacterial strains. Antimicrobial activity of the following was evaluated - A. terreus extract, biogenic silver nanoparticles, and a mixture containing extract and nanoparticles...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429930/preparation-and-characterization-of-solid-dispersion-freeze-dried-efavirenz-polyvinylpyrrolidone-k-30
#13
Lili Fitriani, Alianshar Haqi, Erizal Zaini
The aim of this research is to prepare and characterize solid dispersion of efavirenz - polyvinylpyrrolidone (PVP) K-30 by freeze drying to increase its solubility. Solid dispersion of efavirenz - PVP K-30 was prepared by solvent evaporation method with ratio 2:1, 1:1, and 1:2 and dried using a freeze dryer. Characterizations were done by scanning electron microscopy (SEM), powder X-ray diffraction analysis, differential thermal analysis (DTA), and Fourier transform infrared (FT-IR) spectroscopy. Solubility test was carried out in CO2-free distilled water, and efavirenz assay was conducted using high-performance liquid chromatography with acetonitrile:acetic acid (80:20) as the mobile phases...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429929/resveratrol-mitigates-hepatic-injury-in-rats-by-regulating-oxidative-stress-nuclear-factor-kappa-b-and-apoptosis
#14
Sayed Hassan Seif El-Din, Naglaa Mohamed El-Lakkany, Maha Badr Salem, Olfat Ali Hammam, Samira Saleh, Sanaa Sabet Botros
Resveratrol is a naturally occurring polyphenol, possesses several pharmacological activities including anticancer, antioxidant, antidiabetic, antinociceptive, and antiasthmatic activity. Little is known about its hepatoprotective action mechanisms. This study was conceived to explore the possible protective mechanisms of resveratrol compared with the hepatoprotective silymarin in thioacetamide (TAA)-induced hepatic injury in rats. Thirty-two rats were equally divided into four groups; normal control (i), TAA (100 mg/kg) (ii), TAA + silymarin (50 mg/kg) (iii), and TAA + resveratrol (10 mg/kg) (iv)...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429928/preparation-and-physicochemical-characterization-of-topical-chitosan-based-film-containing-griseofulvin-loaded-liposomes
#15
Neda Bavarsad, Maryam Kouchak, Pardis Mohamadipour, Batool Sadeghi-Nejad
Griseofulvin is an antifungal drug and is available as oral dosage forms. Development of topical treatment could be advantageous for superficial fungal infections of the skin. In this study, films prepared from the incorporation of griseofulvin-loaded liposomes in chitosan film for topical drug delivery in superficial fungal infections. The properties of the films were characterized regarding mechanical properties, swelling, ability to transmit vapor, drug release, thermal behavior, and antifungal efficacy against Microsporum gypseum and Epidermophyton floccosum...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429927/effects-of-cr-3-ions-on-electrophysiological-parameters-of-isolated-skin-of-toad-pleurodema-thaul
#16
Luis Guzman Jofre, Ricardo I Castro Cepeda
In view of the toxicity of chromium (Cr(3+)) ions, it was explored the damaging effects that this ion could induce in cell membranes. The measurement of the effects induced by Cr(3+) ions on electrophysiological parameters of short-circuit current and on the potential difference were investigated using the outer side (mucosal) and the inner side (serosal) of toad Pleurodema thaul skin. The results showed a decreased on electrophysiological parameters when it were administered concentrations of 33, 100 and 200 μM of Cr(3+), the results also suggest that the administration of Cr(3+) inhibits the ion transport in toad skin by the interaction of Cr(3+) with lipid bilayers or protein constituents of membrane, and not by an inhibition of the active transport of ions across Na(+) channels...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429926/conductometric-and-volumetric-studies-of-atorvastatin-in-aqueous-solution-of-arginine-from-298-15-to-313-15-k
#17
M M R Meor Mohd Affandi, Minaketan Tripathy, A B A Majeed
Categorized as a Biopharmaceutics Classification System Class II drugs, atorvastatin (ATV) exhibits low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. Numerous studies are available in regard to the solubility enhancement of ATV, but very few actually describe this phenomenon in terms of thermodynamics and the solute-solvent interaction. Arginine (ARG) is an amino acid that has been reported to enhance the solubility of the highly insoluble wheat protein gluten through hydrogen bonding and π electron-cation interaction...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429925/brush-border-membrane-vesicle-and-caco-2-cell-line-two-experimental-models-for-evaluation-of-absorption-enhancing-effects-of-saponins-bile-salts-and-some-synthetic-surfactants
#18
Eskandar Moghimipour, Sayyed Abolghassem Sajadi Tabassi, Mohammad Ramezani, Somayeh Handali, Raimar Löbenberg
The aim of this study was to investigate the influence of absorption enhancers in the uptake of hydrophilic compounds. The permeation of the two hydrophilic drug models gentamicin and 5 (6)-carboxyfluorescein (CF) across the brush border membrane vesicles and Caco-2 cell lines were evaluated using total saponins of Acanthophyllum squarrosum, Quillaja saponaria, sodium lauryl sulfate, sodium glycocholate, sodium taurodeoxycholate, and Tween 20 as absorption enhancers. Transepithelial electrical resistance (TEER) measurement was utilized to assess the paracellular permeability of cell lines...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429924/accreditation-status-of-hospital-pharmacies-and-their-challenges-of-medication-management-a-case-of-south-iranian-largest-university
#19
Omid Barati, Hesam Dorosti, Alireza Talebzadeh, Peivand Bastani
Considering the importance of accreditation for hospital pharmacies, this study was to determine the challenges of medication management in hospital pharmacies affiliated with Shiraz University of Medical Sciences, Iran. The study was a mix-method research conducted in two qualitative and quantitative phases during the years 2014-2015 in Shiraz, Iran. National Accreditation Standard checklist for hospitals was used for data collection in the first phase, and Delphi method was applied in three rounds to achieve the most challenges of medication management and the related solutions...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429923/hydrotherapy-tool-for-preventing-illness
#20
Upendra Nagaich
No abstract text is available yet for this article.
July 2016: Journal of Advanced Pharmaceutical Technology & Research
journal
journal
43199
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"