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Journal of Advanced Pharmaceutical Technology & Research

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[This retracts the article on p. 18 in vol. 1, PMID: 22247827.].
July 2016: Journal of Advanced Pharmaceutical Technology & Research
Kartikeya Rajpal, Nafe Aziz, Ram Prasad, Ramendra G Varma, Ajit Varma
Therapeutic properties of fungal metabolites and silver nanoparticles have been well documented. While fungal metabolites have been used for centuries as medicinal drugs, potential of biogenic silver nanoparticles has recently received attention. We have evaluated the antimicrobial potential of Aspergillus terreus crude extract, silver nanoparticles and an amalgamation of both against four pathogenic bacterial strains. Antimicrobial activity of the following was evaluated - A. terreus extract, biogenic silver nanoparticles, and a mixture containing extract and nanoparticles...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
Lili Fitriani, Alianshar Haqi, Erizal Zaini
The aim of this research is to prepare and characterize solid dispersion of efavirenz - polyvinylpyrrolidone (PVP) K-30 by freeze drying to increase its solubility. Solid dispersion of efavirenz - PVP K-30 was prepared by solvent evaporation method with ratio 2:1, 1:1, and 1:2 and dried using a freeze dryer. Characterizations were done by scanning electron microscopy (SEM), powder X-ray diffraction analysis, differential thermal analysis (DTA), and Fourier transform infrared (FT-IR) spectroscopy. Solubility test was carried out in CO2-free distilled water, and efavirenz assay was conducted using high-performance liquid chromatography with acetonitrile:acetic acid (80:20) as the mobile phases...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
Sayed Hassan Seif El-Din, Naglaa Mohamed El-Lakkany, Maha Badr Salem, Olfat Ali Hammam, Samira Saleh, Sanaa Sabet Botros
Resveratrol is a naturally occurring polyphenol, possesses several pharmacological activities including anticancer, antioxidant, antidiabetic, antinociceptive, and antiasthmatic activity. Little is known about its hepatoprotective action mechanisms. This study was conceived to explore the possible protective mechanisms of resveratrol compared with the hepatoprotective silymarin in thioacetamide (TAA)-induced hepatic injury in rats. Thirty-two rats were equally divided into four groups; normal control (i), TAA (100 mg/kg) (ii), TAA + silymarin (50 mg/kg) (iii), and TAA + resveratrol (10 mg/kg) (iv)...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
Neda Bavarsad, Maryam Kouchak, Pardis Mohamadipour, Batool Sadeghi-Nejad
Griseofulvin is an antifungal drug and is available as oral dosage forms. Development of topical treatment could be advantageous for superficial fungal infections of the skin. In this study, films prepared from the incorporation of griseofulvin-loaded liposomes in chitosan film for topical drug delivery in superficial fungal infections. The properties of the films were characterized regarding mechanical properties, swelling, ability to transmit vapor, drug release, thermal behavior, and antifungal efficacy against Microsporum gypseum and Epidermophyton floccosum...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
Luis Guzman Jofre, Ricardo I Castro Cepeda
In view of the toxicity of chromium (Cr(3+)) ions, it was explored the damaging effects that this ion could induce in cell membranes. The measurement of the effects induced by Cr(3+) ions on electrophysiological parameters of short-circuit current and on the potential difference were investigated using the outer side (mucosal) and the inner side (serosal) of toad Pleurodema thaul skin. The results showed a decreased on electrophysiological parameters when it were administered concentrations of 33, 100 and 200 μM of Cr(3+), the results also suggest that the administration of Cr(3+) inhibits the ion transport in toad skin by the interaction of Cr(3+) with lipid bilayers or protein constituents of membrane, and not by an inhibition of the active transport of ions across Na(+) channels...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
M M R Meor Mohd Affandi, Minaketan Tripathy, A B A Majeed
Categorized as a Biopharmaceutics Classification System Class II drugs, atorvastatin (ATV) exhibits low aqueous solubility and bioavailability thus presenting an obstacle and great challenge to formulation researchers. Numerous studies are available in regard to the solubility enhancement of ATV, but very few actually describe this phenomenon in terms of thermodynamics and the solute-solvent interaction. Arginine (ARG) is an amino acid that has been reported to enhance the solubility of the highly insoluble wheat protein gluten through hydrogen bonding and π electron-cation interaction...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
Eskandar Moghimipour, Sayyed Abolghassem Sajadi Tabassi, Mohammad Ramezani, Somayeh Handali, Raimar Löbenberg
The aim of this study was to investigate the influence of absorption enhancers in the uptake of hydrophilic compounds. The permeation of the two hydrophilic drug models gentamicin and 5 (6)-carboxyfluorescein (CF) across the brush border membrane vesicles and Caco-2 cell lines were evaluated using total saponins of Acanthophyllum squarrosum, Quillaja saponaria, sodium lauryl sulfate, sodium glycocholate, sodium taurodeoxycholate, and Tween 20 as absorption enhancers. Transepithelial electrical resistance (TEER) measurement was utilized to assess the paracellular permeability of cell lines...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
Omid Barati, Hesam Dorosti, Alireza Talebzadeh, Peivand Bastani
Considering the importance of accreditation for hospital pharmacies, this study was to determine the challenges of medication management in hospital pharmacies affiliated with Shiraz University of Medical Sciences, Iran. The study was a mix-method research conducted in two qualitative and quantitative phases during the years 2014-2015 in Shiraz, Iran. National Accreditation Standard checklist for hospitals was used for data collection in the first phase, and Delphi method was applied in three rounds to achieve the most challenges of medication management and the related solutions...
July 2016: Journal of Advanced Pharmaceutical Technology & Research
Upendra Nagaich
No abstract text is available yet for this article.
July 2016: Journal of Advanced Pharmaceutical Technology & Research
Syed Ahamed Raheel, Omar Bashar Kujan, Bassel Tarakji, Dilshad Umar, Salah Ibrahim
Drug reactions are a group of reactionary lesions generally show their manifestations in the oral cavity. The drug reactions may vary from local rashes to well-developed swellings in the oral cavity especially involving the gingiva. Most of the drug reactions are asymptomatic and commonly triggered from the active metabolite of a drug used for a long time. Nager syndrome is a group of acrofacial dysostosis that usually results in craniofacial and limb malformations. The craniofacial defects are very similar to the mandibulofacial dysostosis...
April 2016: Journal of Advanced Pharmaceutical Technology & Research
Ramadhani S O Nondo, Paul Erasto, Mainen J Moshi, Abdallah Zacharia, Pax J Masimba, Abdul W Kidukuli
Plants used in traditional medicine have been the source of a number of currently used antimalarial medicines and continue to be a promising resource for the discovery of new classes of antimalarial compounds. The aim of this study was to evaluate in vivo antimalarial activity of four plants; Erythrina schliebenii Harms, Holarrhena pubescens Buch-Ham, Phyllanthus nummulariifolius Poir, and Caesalpinia bonducella (L.) Flem used for treatment of malaria in Tanzania. In vivo antimalarial activity was assessed using the 4-day suppressive antimalarial assay...
April 2016: Journal of Advanced Pharmaceutical Technology & Research
Sanaa Sabet Botros, Naglaa Mohamed El-Lakkany, Olfat Ali Hammam, Abdel-Naser Abdel-Aal Sabra, Alaa Awad Taha
Dimethyl dimethoxy biphenyl dicarboxylate (DDB) has been extensively used in the treatment of liver diseases accounting for 1-6% of the global disease burden. Cell replication, DNA synthesis, and proliferation, providing significant information about behavior of cells were examined in mice exposed to subchronic administration with DDB. Conventional liver functions specifically gamma-glutamyltransferase (γ-GT), a marker expressing liver canceration was also investigated. Normal mice were allocated into two groups each of 10 mice...
April 2016: Journal of Advanced Pharmaceutical Technology & Research
Sathvik Belagodu Sridhar, Padma Gurumadhva Rao, Satendra Kumar Multani, Meenakshi Jain
United Arab Emirates (UAE) has a high prevalence of hypovitaminosis D. Not much data are available regarding the prevalence of Vitamin D deficiency among multiethnic UAE adult population. (1) To determine the prevalence of hypovitaminosis D in multiethnic UAE population (2) To compare the Vitamin D status in Arab and non-Arab population (3) To identify the demographic variables associated with hypovitaminosis D. It was a retrospective study conducted at a secondary care hospital. Electronic case records of all the subjects who had checked their Vitamin D levels during the time period of May 2010-October 2012 were considered for the study...
April 2016: Journal of Advanced Pharmaceutical Technology & Research
Parvin Safavi, Ali Hasanpour-Dehkordi, Maryam AmirAhmadi
Although pharmacotherapy with atypical antipsychotics is common in child psychiatry, there has been little research on this issue. To compare the efficacy and safety of risperidone and aripiprazole in the treatment of preschool children with disruptive behavior disorders comorbid with attention deficit-hyperactivity disorder (ADHD). Randomized clinical trial conducted in a university-affiliated child psychiatry clinic in southwest Iran. Forty 3-6-year-old children, diagnosed with oppositional defiant disorder comorbid with ADHD, were randomized to an 8-week trial of treatment with risperidone or aripiprazole (20 patients in each group)...
April 2016: Journal of Advanced Pharmaceutical Technology & Research
Yamon Pitakpawasutthi, Worathat Thitikornpong, Chanida Palanuvej, Nijsiri Ruangrungsi
Chromolaena odorata (L.) R. M. King and H. Rob. is a Thai medicinal plant used for the treatment of wounds, rashes, diabetes, and insect repellent. The leaves of C. odorata were collected from 10 different sources throughout Thailand. The chemical constituents of essential oils were hydro-distilled from the leaves and were analyzed by gas chromatography-mass spectrometry. Chlorogenic acid contents were determined by thin-layer chromatography (TLC) - densitometry with winCATS software and TLC image analysis with ImageJ software...
April 2016: Journal of Advanced Pharmaceutical Technology & Research
A Ibeyaima, Jyoti Rana, Anuj Dwivedi, Sanjay Gupta, Sanjeev K Sharma, Narendra Saini, Indira P Sarethy
During a screening program for antimicrobial compounds from underexplored habitats, a Gram-positive bacterium TD-032, was isolated from arid soil, Thar Desert (India), and analyzed for its morphological, physicochemical, and antimicrobial properties. The 16S ribosomal DNA (rDNA) sequence of the isolate was further studied for the novelty of γ-hyper variable region. TD-032 was grown in large-scale culture, and aqueous and organic solvent extracts analyzed for antimicrobial activity. Culture characteristics showed a lack of diffusible and melanoid pigments...
April 2016: Journal of Advanced Pharmaceutical Technology & Research
Upendra Nagaich
No abstract text is available yet for this article.
April 2016: Journal of Advanced Pharmaceutical Technology & Research
Shamsuddin, Mohammad Fazil, Shahid H Ansari, Javed Ali
Atorvastatin calcium is a lipid-lowering agent. It has approximately 15% of bioavailability, remaining amount of drug showed adverse effect which is undesirable for patients. The objective of the study was to enhance the solubility and a dissolution profile of the atorvastatin (AT) calcium. Solid dispersion (SD) is a technique which enhances the solubility and a dissolution profile of poorly soluble drug. Various methods are being used for SDs such as microwave irradiation fusion, kneading, solvent evaporation, fusion, and dropping method...
January 2016: Journal of Advanced Pharmaceutical Technology & Research
Amal Kumar, Bhaswat S Chakraborty
Clinical research operates in a strictly regulated environment under various management models, but a distinct management model of clinical trial (CT) still needs exploration and research. Critical path analysis (CPA) is a management approach can be used for monitoring, analysis, and prediction of success of its time-bound operational activities. A model CT was compiled with 78 activities, which were further merged into 35 major activities. After performing dependence analysis, the list was finalized with 25 activities which were taken in activity predecessor to create a network diagram and perform CPA considering patients, conduct, and outcome...
January 2016: Journal of Advanced Pharmaceutical Technology & Research
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