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Journal of Advanced Pharmaceutical Technology & Research

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https://www.readbyqxmd.com/read/28217554/innate-antioxidant-activity-of-some-traditional-formulations
#1
Gunpreet Kaur, Vikas Gupta, Parveen Bansal
Herbal medicine is the oldest form of healthcare known to humanity. Recently, much attention is being directed toward the use of antioxidants. There are some very commonly used Ayurvedic preparations that might have inbuilt antioxidant activity, and their therapeutic potential can be partially attributable to its antioxidant activity. Hence, it was proposed to find out antioxidant activity of such common formulations. Estimation of innate antioxidant activity of some commonly used traditional formulations. In this study, five formulations were evaluated for antioxidant activity in comparison to gallic acid (standard) using the in vitro reducing power method and superoxide radical scavenging activity by dimethyl sulfoxide method followed by calculation of scavenging activity and inhibitory concentration 50% (IC50)...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28217553/effect-of-vestibular-stimulation-on-auditory-and-visual-reaction-time-in-relation-to-stress
#2
Archana Rajagopalan, Sai Sailesh Kumar, Joseph Kurien Mukkadan
The present study was undertaken to provide scientific evidence and for beneficial effects of vestibular stimulation for the management of stress-induced changes in auditory and visual reaction time (RT). A total of 240 healthy college students of the age group of 18-24 of either gender were a part of this research after obtaining written consent from them. RT for right and left response was measured for two auditory stimuli (low and high pitch) and visual stimuli (red and green) were recorded. A significant decrease in the visual RT for green light and red light was observed and stress-induced changes was effectively prevented followed by vestibular stimulation...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28217552/effectiveness-and-safety-of-topical-tacrolimus-in-treatment-of-vitiligo
#3
Ghasem Rahmatpour Rokni, Massoud Golpour, Alimorad Heidari Gorji, Alireza Khalilian, Hamta Ghasemi
Vitiligo is one of the most primitive well-known dermatoid disorders with different suggested therapies. Therefore, this study investigated the efficiency and safety of topical tacrolimus in treatment of patients with vitiligo. This study was a clinical randomized designed study pre- post-test method, has been conducted on thirty cases with vitiligo who have referred to polyclinic and dermatology clinic. Participant's evaluated and demographic information recorded in designed checklist. In the next stage, the disease activity scored by vitiligo index disease activity system...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28217551/cost-effectiveness-of-glaucoma-management-with-monotherapy-medications-in-egypt
#4
Amal Abd-Elaal El-Khamery, Amir Ibrahim Mohamed, Hassan Eisa Hassan Swify, Alaa Ibrahim Mohamed
Glaucoma is a serious chronic ophthalmic disease since it causes irreversible visual disability if untreated can lead to blindness. Treatment options include medications (classified into five major classes of drugs which are muscarinic cholinergic agonists, alpha-2 adrenergic agonists, beta-1 adrenergic antagonists, prostaglandins [PGs], and carbonic anhydrase inhibitors); use of laser therapy or conventional surgery. Pharmacoeconomic analysis helps in choosing among this variety of treatments. There is a great need for such analysis in Egypt since undergoing of it in different countries or societies may produce different results...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28217550/antidiabetic-and-anticancer-activities-of-mangifera-indica-cv-okrong-leaves
#5
Aunyachulee Ganogpichayagrai, Chanida Palanuvej, Nijsiri Ruangrungsi
Diabetes and cancer are a major global public health problem. Plant-derived agents with undesirable side-effects were required. This study aimed to evaluate antidiabetic and anticancer activities of the ethanolic leaf extract of Mangifera indica cv. Okrong and its active phytochemical compound, mangiferin. Antidiabetic activities against yeast α-glucosidase and rat intestinal α-glucosidase were determined using 1 mM of p-nitro phenyl-α-D-glucopyranoside as substrate. Inhibitory activity against porcine pancreatic α-amylase was performed using 1 mM of 2-chloro-4 nitrophenol-α-D-maltotroside-3 as substrate...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28217549/anticoagulation-control-among-patients-with-nonvalvular-atrial-fibrillation-a-single-tertiary-cardiac-center-experience
#6
Shaban Mohammed, Amer H S Aljundi, Mohamed Kasem, Mohammed Alhashemi, Ayman El-Menyar
There is a limited knowledge about the predictors of anticoagulation control in patients with nonvalvular atrial fibrillation (NVAF). Furthermore, few reports addressed the role of time in therapeutic range (TTR) that could reflect the safety and efficacy of anticoagulation therapy. We aimed to assess factors that affect the quality of anticoagulation therapy utilizing TTR in patients with NVAF. A retrospective observational study was conducted for patients with NVAF who were maintained on warfarin >6 months at a tertiary cardiac care hospital...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28217548/polygonum-multiflorum-root-extract-as-a-potential-candidate-for-treatment-of-early-graying-hair
#7
Nguyen Dinh Thang, Pham Ngoc Diep, Pham Thi Huong Lien, Le Thi Lien
Despite Polygonum multiflorum (PM) has been experiencely used as a drug to treat early graying hair phenomenon in Asian countries for a long time, there is limited study examined the real biological effects of PM on hair graying in vitro and in vivo. In this study, we investigated the effects of PM root extract (PM-RE) on melanin synthesis in human melanoma SKMEL-28 cells and embryos/larvae of wild-type strain AB zebrafish. We also preliminary revealed the molecular mechanism of early hair graying phenomenon in both in vitro and in vivo models...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28217547/a-study-of-the-formation-of-magnetically-active-solid-dispersions-of-phenacetin-using-atomic-and-magnetic-force-microscopy
#8
Liana Stanislavovna Usmanova, Marat Akhmedovich Ziganshin, Valery Vilenovich Gorbatchuk, Sufia Askhatovna Ziganshina, Dmitry Anatolevich Bizyaev, Anastas Akhmetovich Bukharaev, Timur Anvarovich Mukhametzyanov, Alexander Vladimirovich Gerasimov
A lot of pharmaceutical substances have a poor solubility that limits their absorption and distribution to the targeted sites to elicit the desired action without causing untoward effects on healthy cells or tissues. For such drugs, new modes of delivery have to be developed for efficient and effective delivery of the drug to the target site. Formation of magnetically active solid dispersion of such drugs could be a useful approach to addressing this problem because they combine targeted delivery and good solubility...
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28217546/microneedles-mediated-drug-and-vaccine-delivery
#9
EDITORIAL
Upendra Nagaich
No abstract text is available yet for this article.
January 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833897/anticancer-antioxidant-potential-and-profiling-of-polyphenolic-compounds-of-wrightia-tinctoria-roxb-r-br-bark
#10
Nishat Fatima, Mohammad Kaleem Ahmad, Jamal Akhtar Ansari, Zulfiqar Ali, Abdul Rahman Khan, Abbas Ali Mahdi
Wrightia tinctoria Roxb. (R.Br.) is an Ayurvedic remedy, ethnomedically used in the treatment of various ailments. The present work was carried out to evaluate the anticancer and antioxidant activity as well as total phenolic and phytochemical contents of W. tinctoria bark methanolic extract (WTBM) by high-performance liquid chromatography (HPLC)-diode array detector. Antiproliferative activity of WTBM was evaluated against MDA-MB-231 and MCF-7 cancer cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation, and Hoechst staining...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833896/isolation-and-characterization-of-quinine-from-polygonatum-verticillatum-a-new-marker-approach-to-identify-substitution-and-adulteration
#11
Jaswinder Kaur Virk, Sanjiv Kumar, Ranjit Singh, Avinash C Tripathi, Shailendra K Saraf, Vikas Gupta, Parveen Bansal
Polygonatum verticillatum (Mahameda) is an important ingredient of Ashtawarga and Ayurvedic formulations. Nowadays, it comes under the category of endangered plants due to large scale and indiscriminate collection of wild material. To overcome the scarcity, substitutes of Mahameda are also commonly used in market. These additives are different from the authentic plant by Ayurvedic and pharmacological theory of drug action, thereby resulting in substitution/adulteration. Substitution is a critical issue in isolation and quantification of the therapeutically active ingredients that can be used as markers in the identification of substitution/adulteration...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833895/evaluation-of-antibacterial-activity-of-achyranthes-aspera-extract-against-streptococcus-mutans-an-in-vitro-study
#12
Roma Yadav, Radhika Rai, Abhishek Yadav, Meetika Pahuja, Savita Solanki, Himani Yadav
Dental caries and periodontal diseases have historically been considered the most important global oral health burdens. Many chemicals and synthetic drugs have marked the side effects. Hence, there has been a paradigm shift from the use of modern drugs to the age-old herbs. Achyranthes aspera is one such important plant with various established pharmaceutical properties. The aim of this study was to assess the antibacterial activity of the A. aspera extract against Streptococcus mutans. Aqueous extract of A...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833894/comparison-of-the-effects-of-methylphenidate-and-the-combination-of-methylphenidate-and-risperidone-in-preschool-children-with-attention-deficit-hyperactivity-disorder
#13
Parvin Safavi, Ali Hasanpour Dehkordi, Nasim Ghasemi
Attention-deficit hyperactivity disorder (ADHD) is a common psychiatric disorder among preschool children but the number of controlled clinical trials regarding psychopharmacological treatment in this age group is limited. The aim of this study was to compare methylphenidate with the combination of methylphenidate and risperidone in preschool children with ADHD. Forty-two preschool children, aged 3-6 years, diagnosed with ADHD by a child and adolescent psychiatrist according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition-Text Revision criteria, were enrolled in a 6-week, single-blind clinical trial and administered with methylphenidate (5-30 mg/dl) or the combination of methylphenidate and risperidone (0...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833893/thermoreversible-gel-for-intrapocket-delivery-of-green-tea-catechin-as-a-local-drug-delivery-system-an-original-research
#14
M Yuvaraja, N Raghavendra Reddy, P Mohan Kumar, K S Ravi, Nabeeh Alqahtani
The periodontal therapies along with systemic antibiotic therapy aim at eliminating the subgingival microbiota to arrest the progression of periodontal diseases. The complete elimination is often difficult, and thus the probability of repopulation after periodontal therapy is also high. The objectives of the study are to develop in situ thermoreversible gelling system of green tea catechins suitable for periodontal pocket administration, which would act as an adjunct to mechanical periodontal therapy. Gel is prepared on a weight basis using a cold process...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833892/pharmacognostic-specification-of-zanthoxylum-limonella-dennst-alston-fruits-and-seeds-in-thailand
#15
Rawiwan Charoensup, Thidarat Duangyod, Pravaree Phuneerub, Chatubhong Singharachai
Zanthoxylum limonella (Dennst.) Alston. (Rutaceae) or Ma-khwaen is one of the medicinal plants in Thai traditional medicine. To investigate the pharmacognostic specifications and chemical constituents of Z. limonella fruits and seeds. Fruits and seeds of Z. limonella were collected from 15 sources throughout Thailand; then examined the pharmacognostic specification following WHO guideline of quality control method for medicinal plant materials. Microscopic determination of Z. limonella powders demonstrated fragment of mesocarp, fragment of brown vitta, oil glands, fragment of endocarp, and endosperm containing oil globule, trichome and pale brown stone cells...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833891/characterization-of-mangifera-indica-cultivars-in-thailand-based-on-macroscopic-microscopic-and-genetic-characters
#16
Aunyachulee Ganogpichayagrai, Kanchana Rungsihirunrat, Chanida Palanuvej, Nijsiri Ruangrungsi
Thai mango cultivars are classified into six groups plus one miscellaneous group according to germplasm database for mango. Characterization is important for conservation and the development of Thai mango cultivars. This study investigated macroscopic, microscopic leaf characteristics, and genetic relationship among 17 cultivars selected from six groups of mango in Thailand. Selected mango samples were obtained from three different locations in Thailand (n = 57). They were observed for their leaf and fruit macroscopic characteristics...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833890/neuroanatomical-changes-in-parkinson-s-disease-in-relation-to-cognition-an-update
#17
REVIEW
K G Prakash, B M Bannur, Madhavrao D Chavan, K Saniya, Kumar Sai Sailesh, Archana Rajagopalan
The pathophysiological changes underlying impairment of cognition in Parkinson's disease (PD) are complex and not fully understood till date. Hence, understanding the structural changes responsible for cognitive decline in PD is essential for early diagnosis and to offer effective treatment. In this review, we discuss the neuroanatomical changes in major brain structures responsible for cognition in PD. We have included the key findings of various studies to provide up-to-date information for better understanding of pathophysiology of PD, which will help researchers and clinicians in planning and developing new treatment methods for the benefit of PD patients...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833889/interim-analysis-a-rational-approach-of-decision-making-in-clinical-trial
#18
REVIEW
Amal Kumar, Bhaswat S Chakraborty
Interim analysis of especially sizeable trials keeps the decision process free of conflict of interest while considering cost, resources, and meaningfulness of the project. Whenever necessary, such interim analysis can also call for potential termination or appropriate modification in sample size, study design, and even an early declaration of success. Given the extraordinary size and complexity today, this rational approach helps to analyze and predict the outcomes of a clinical trial that incorporate what is learned during the course of a study or a clinical development program...
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27833888/deformable-vesicles-alternatives-in-topical-drug-delivery
#19
EDITORIAL
Upendra Nagaich
No abstract text is available yet for this article.
October 2016: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/27429932/retraction-case-report-and-clinical-databased-research-study-on-malaria
#20
(no author information available yet)
[This retracts the article on p. 18 in vol. 1, PMID: 22247827.].
July 2016: Journal of Advanced Pharmaceutical Technology & Research
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