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Journal of Advanced Pharmaceutical Technology & Research

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https://www.readbyqxmd.com/read/29441323/the-ethanolic-extract-of-ashitaba-stem-angelica-keskei-miq-koidz-as-future-antituberculosis
#1
Sri Agung Fitri Kusuma, Yoppi Iskandar, Mutiara Ayu Dewanti
Considering the easy contagion of tuberculosis (TB) disease spread and the emergence of multidrug-resistant TB, which directly impacts the failure of therapeutic goals and mortality rates increasing, TB disease control remains to be the main concern of continuous health development effort. Therefore, the discovery of new TB drug is needed. This research assessed the new natural anti-TB drug from the ethanolic extract of Angelica keiskei stem obtained from Lombok, Indonesia. The objectives of this study were to evaluate the sensitivity of Mycobacterium tuberculosis (Mtb) H37Rv strain to A...
January 2018: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29441322/effect-of-vitamin-e-and-omega-3-fatty-acids-in-type-2-diabetes-mellitus-patients
#2
Ashwitha Shruti Dass, Sarala Narayana, P N Venkatarathnamma
Diabetes mellitus (DM) and its complications have been implicated in hyperglycemia-induced oxidative stress. Antioxidants can improve glycemic control, lipid profile, and cognitive functions. We assessed the effect of Vitamin E and omega 3 fatty acids (OFA) on the above parameters. One hundred patients with type 2 DM receiving metformin 500 mg and glimepiride 1 mg were randomized to receive add-on therapy of Vitamin E 400 mg or OFA once daily for 12 weeks and the third group served as control. Fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), body mass index (BMI), waist-hip ratio (WHR), lipid profile, and mini-mental state examination were done at baseline and 12 weeks...
January 2018: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29441321/quality-evaluation-of-kaempferia-parviflora-rhizome-with-reference-to-5-7-dimethoxyflavone
#3
Yamon Pitakpawasutthi, Chanida Palanuvej, Nijsiri Ruangrungsi
Kaempferia parviflora Wall. ex Baker is a medicinal plant found in the upper Northeastern regions of Thailand, which belongs to Zingiberaceae family. The present study aims to investigate the standardization parameters, to analyze chemical constituents of volatile oil by gas chromatography-mass spectrometry, and to determine the content of 5,7-dimethoxyflavone in K. parviflora rhizomes by thin-layer chromatography (TLC)-densitometry compared to TLC image analysis. K. parviflora rhizomes from 15 different sources throughout Thailand were investigated for morphological and pharmacognostic parameters...
January 2018: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29441320/zika-virus-disease-knowledge-among-the-future-health-care-providers-of-the-united-arab-emirates
#4
Syed Arman Rabbani, Farhan Mustafa, Tasneem Shouqair, Itaf Mohamad, Nada Tahsin
Zika virus (ZIKV) disease has become a major public health concern. Although there are no reported cases of ZIKV disease in the United Arab Emirates (UAE), there is a potential risk of transmission due to large expatriate population and high influx of international travelers. This cross-sectional study was conducted to assess the knowledge of ZIKV disease among the students of a medical and health sciences university in the UAE. Their knowledge of ZIKV disease was assessed using a specially designed, pretested, and validated questionnaire...
January 2018: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29441319/the-effect-of-calendula-officinalis-versus-metronidazole-on-bacterial-vaginosis-in-women-a-double-blind-randomized-controlled-trial
#5
Zahra Pazhohideh, Solmaz Mohammadi, Nosrat Bahrami, Faraz Mojab, Parvin Abedi, Elham Maraghi
Bacterial vaginosis (BV) is a common disorder among women of reproductive age. This study aimed to compare the effect of a Calendula officinalis extract-based cream and metronidazole on BV among women of reproductive age. In this study, 80 women of reproductive age with BV were randomly assigned to the C. officinalis ( n = 40) or metronidazole ( n = 40). Diagnosis of BV was confirmed when at least 3 of the 4 Amsel criteria were met (pH >4.5, whitish grey or thin homogeneous discharge, release of a fishy odor on adding 10% KOH, and detection of clue cells on microscopic examination)...
January 2018: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29441318/the-off-label-use-of-drugs-for-parenteral-nutrition-as-a-solvent-of-substances-slightly-soluble-in-water-in-pharmacological-research
#6
Aleksandr L Urakov, Ilshat G Mustafin, Aleksandr V Samorodov, Felix Kh Kamilov, Ferkat A Khaliullin
Because of the problem to evaluate biological activity in water-soluble substances in all phases of preclinical and clinical studies, the research work enabled to develop the original solvent for poorly soluble compounds based on substances for parenteral nutrition. The main aim is to examine the impact of the original solvent based on substances for parenteral nutrition on biological systems exemplified by the hemostatic system, characterized by sensitivity and variability of the effects in response to any impact, and its comparison with the solvents that are conventional in pharmacological research...
January 2018: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29441317/polymeric-micelles-as-cutaneous-drug-delivery-system-in-normal-skin-and-dermatological-disorders
#7
REVIEW
Behzad Sharif Makhmalzade, Fateme Chavoshy
The easy accessibility of skin made dermal application, one of the approaches for local drug therapy. Effectiveness of topical drug application is depended on different parameters such as skin barrier properties, physicochemical properties of drug and vehicle, and interaction between drug and its vehicle with the skin layers. In this review, an overview of skin structure and feature of polymeric micelles as topical nanocarriers is provided. We also summarized the research studies dealing with the application of polymeric micelles for cutaneous delivery...
January 2018: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29441316/pharmaceutical-quality-by-design-approach
#8
EDITORIAL
Upendra Nagaich
No abstract text is available yet for this article.
January 2018: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29184847/novel-biorelevant-dissolution-medium-as-a-prognostic-tool-for-polysaccharide-based-colon-targeted-drug-delivery-system
#9
Ankit Kumar Yadav, Manik Sadora, Sachin Kumar Singh, Monica Gulati, Peddi Maharshi, Abhinav Sharma, Bimlesh Kumar, Harish Rathee, Deepak Ghai, Adil Hussain Malik, Varun Garg, K Gowthamrajan
To overcome the limitations of the conventionally used methods for evaluation of orally administered colon-targeted delivery systems, a novel dissolution method using probiotics has been recently reported. In the present study, universal suitability of this medium composed of five different probiotics is established. Different delivery systems - mini tablets, liquisolid compacts, and microspheres coated with different polysaccharides - were prepared and subjected to sequential dissolution testing in medium with and without microbiota...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29184846/-acacia-catechu-ethanolic-bark-extract-induces-apoptosis-in-human-oral-squamous-carcinoma-cells
#10
Thangavelu Lakshmi, Devaraj Ezhilarasan, Rajagopal Vijayaragavan, Sukhwinder Kaur Bhullar, Ramasamy Rajendran
Oral cancer is in approximately 30% of all cancers in India. This study was conducted to evaluate the cytotoxic activity of ethanolic extract of Acacia catechu bark (ACB) against human squamous cell carcinoma cell line-25 (SCC-25). Cytotoxic effect of ACB extract was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide assay. A. catechu extract was treated SCC-25 cells with 25 and 50 μg/mL for 24 h. Apoptosis markers such as caspases-8 and 9, bcl-2, bax, and cytochrome c (Cyt-c) were done by RT-PCR...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29184845/the-effect-of-adding-ferrous-sulfate-to-methylphenidate-on-attention-deficit-hyperactivity-disorder-in-children
#11
Gholamreza Panahandeh, Bahareh Vatani, Parvin Safavi, Abolfazl Khoshdel
Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children with several complications. This study was conducted to investigate the effect of adding ferrous sulfate to methylphenidate in decreasing ADHD symptoms. This study was a double-blind, randomized clinical trial. In this study, 42 nonanemic children with ADHD and serum ferritin below 30 mg/ml were enrolled according to convenience sampling and randomly assigned to two groups of 21 each, cases and controls...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29184844/effect-of-different-doses-of-oxytocin-on-cardiac-electrophysiology-and-arrhythmias-induced-by-ischemia
#12
Fariba Houshmand, Mahdieh Faghihi, Alireza Imani, Soleiman Kheiri
The onset of acute myocardial ischemia (MI) is accompanied by a rapid increase in electrical instability and often fatal ventricular arrhythmias. This study investigated that whether oxytocin (OT) can modulate ischemia-induced arrhythmias and considered relationships between the severity of arrhythmia and the electrocardiogram parameters during ischemia. OT (0.0001-1 μg) was administrated intraperitoneally 30 min before ischemia. To examine receptor involved, a selective OT-receptor antagonist, atosiban (ATO), was infused 10 min before OT...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29184843/the-performance-implications-of-pharmacy-information-system-at-the-university-teaching-hospitals-of-shiraz-iran-cluster-approach
#13
Saeede Bayati, Peivand Bastani, Zahra Mahmoodzade Sagheb, Sara Jamalabadi, Mahnaz Samadbeik
Pharmacy information system (PIS) is becoming vital in assisting pharmacists to do their responsibilities. The aim of this study was to identify the current PIS implications in teaching hospitals affiliated with Shiraz University of Medical Science. This cross-sectional study was conducted in teaching hospitals affiliated with Shiraz University of Medical Science over the year 2016. Data were collected by observing the PIS as well as interviewing its users based on the researcher-made checklist. The checklist was prepared based on reviewing the Persian and English literature and its content validity was approved by the experts...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29184842/the-status-of-iranian-hospital-pharmacies-according-to-age-friendly-pharmacies-criteria
#14
Peivand Bastani, Milad Ahmadi Marzaleh, Mina Dehghani, Maryam Falahatzadeh, Elahe Rahmati, Ali Tahernezhad
Due to the increasing elderly population and the subsequent increase in their need for medication and more referrals to the pharmacy, this study was conducted to investigate the Iranian hospital pharmacies in terms of age-friendliness criteria. This was a cross-sectional study conducted in 2017. The study population included 3 metropolitan hospital pharmacies selected through clustered sampling, and all their 67 pharmacies were included by census. Data collection tool was a reliable researcher-made checklist (t = 0...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29184841/evaluation-of-the-anesthetic-effect-of-nasal-mucosa-with-tetracaine-0-5-on-hemodynamic-changes-and-postoperative-pain-of-septoplasty-a-randomized-controlled-trial
#15
Hossein Madineh, Soroush Amani, Majid Kabiri, Behnam Karimi
The nasal septum repair surgery is the dangerous operations that any stimulation of this area causes a large change in the rhythm of the heartbeat and blood pressure. This study aimed to determine the effects of tetracaine 0.5% on changes in heartbeat and heart rhythm, hemodynamic changes during surgery, intraoperative bleeding, and pain after septoplasty surgery. The irregular double-blind clinical trial registry of clinical trials Iran with the code number (IRCT: 20150526625N8) in the first half of 2013 on 86 patients in Kashani hospital of Shahrekord...
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/29184840/personalized-medicine-an-era-of-dosage-form-development
#16
EDITORIAL
Upendra Nagaich
No abstract text is available yet for this article.
October 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28795025/sub-chronic-safety-evaluation-of-aqueous-extract-of-alangium-salvifolium-l-f-wangerin-leaves-in-rats
#17
Bhupinder Kapoor, Gagandeep Kaur, Mukta Gupta, Reena Gupta
Conventionally, the juice and extract of Alangium salvifolium leaves have been used for the treatment of diabetes, wound healing, dog bite, and as a poultice in rheumatism. To carry out the sub-chronic toxicity and thereafter safety evaluation of A. salvifolium leaves. The aqueous extract of A. salvifolium leaves was administered orally at the doses of 200, 400, and 800 mg/kg/day for 90 days. All the animals were observed daily for general behavior, changes in body weight, food, and water consumption. At the end of the treatment period, biochemical and hematological parameters were analyzed; and the animals were sacrificed for histopathological examination of heart, lungs, liver, and kidney...
July 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28795024/chemopreventive-effect-of-artesunate-in-1-2-dimethylhydrazine-induced-rat-colon-carcinogenesis
#18
Sazal Patyar, Rakesh Raman Patyar, Bikash Medhi, Krishan Lal Khanduja
Artesunate (ART) is a semisynthetic derivative of artemisinin. Artemisinin and its derivatives have shown profound cytotoxicity and antitumor activity in addition to antimalarial activity in various studies. As the in vivo chemopreventive efficacy of ART in colon carcinogenesis has not been investigated so far, the aim of the current study was to study the chemopreventive effect of ART in 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. Animals were divided into four groups (n = 6): Group I - vehicle (1 mM ethylenediaminetetraacetic acid), Group II - DMH (20 mg/kg), Group III - DMH + 5-fluorouracil (81 mg/kg), Group IV - DMH + ART (6...
July 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28795023/leptocarpus-disjunctus-prolongs-sleeping-time-and-increases-nonrapid-eye-movement-sleep-with-additional-anxiolytic-capacity
#19
Watchara Damjuti, Thanes Fuangfoo, Chanida Palanuvej, Tingli Li, Nijsiri Ruangrungsi
Leptocarpus disjunctus Mast. (Restionaceae) is an edible plant which has indigenous warnings regarding its side effects which can manifest as dizziness. This study investigated hypnotic and anxiolytic properties using several animal models. Anxiolytic activities were evaluated using locomotor determination by elevated plus-maze test, open-field test, and rotarod performance test. Hypnotic activities were performed using pentobarbital sodium-induced sleeping time test. Sleep architecture and quality were obtained from sleep-wake analysis and nonrapid eye movement (NREM) delta activity using electroencephalography...
July 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28795022/the-potency-of-chicken-egg-yolk-immunoglobulin-igy-specific-as-immunotherapy-to-mycobacterium-tuberculosis-infection
#20
Sri Agus Sudjarwo, Koerniasari Eraiko, Giftania Wardani Sudjarwo, Koerniasari
The aim of this study was to characterize of chicken egg yolk immunoglobulins (IgYs) specific as immunotherapy to Mycobacterium tuberculosis complex (MTBC) infection. Lohmann laying hens were immunized intramuscularly with antigenic of MTBC. Egg yolk was separated from egg white, and IgY antibody was then purified by multiple polyethylene glycols 6000 extraction and ammonium sulfate purification steps. The IgY anti-MTBC concentration in egg yolk increased at 2 weeks and it reached a maximum at 4 weeks after immunization...
July 2017: Journal of Advanced Pharmaceutical Technology & Research
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