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Journal of Pharmacy & Bioallied Sciences

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https://www.readbyqxmd.com/read/29962801/lab-on-a-chip-conquer-disease-at-the-earliest
#1
Gibson S T Daniel, Manigandan Thiruppathy, Nalini Aswath, Sankar R Narayanan
Oral cancer is the fifth most common cancer in the world, accounting for numerous deaths annually. The 5-year survival rate remains approximately 50% for oral squamous cell carcinoma (OSCC) in the past several decades. Early detection plays a vital role in the survival rate of the patients. There is no accurate, cost-effective, and reliable method for the screening of patients with OSCC. Hence, many patients are diagnosed at advanced stages. Early detection would, therefore, help to identify patients and modify treatment with close monitoring...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29962800/eosinophilia-in-advanced-hiv-infection-with-hyperinfection-syndrome-a-case-report
#2
Pratima Gupta, Ruchi Dua, Mohit Bhatia, Puneet K Gupta, Neelam Kaistha
Strongyloides stercoralis is a soil-transmitted helminth that occurs almost worldwide, yet estimates about its prevalence are not well documented. The spectrum of clinical manifestations of strongyloidiasis is wide, ranging from asymptomatic disease to hyperinfection or dissemination of larvae involving multiple organ systems. Immunosuppression can increase the risk of hyperinfection syndrome in patients with strongyloidiasis. Strongyloidiasis continues to remain a neglected tropical disease, the diagnosis of which is often overlooked by clinicians and diagnosticians alike...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29962799/emerging-biocide-resistance-among-multidrug-resistant-bacteria-myth-or-reality-a-pilot-study
#3
Priyanka Gupta, Mohit Bhatia, Pratima Gupta, Balram J Omar
Context: Possible linkage between biocide and antibiotic resistance in bacteria is a major area of concern. Aim: To evaluate the susceptibility of multidrug-resistant (MDR) bacteria to four commonly used biocides. Settings and Design: A pilot study was conducted in a tertiary care hospital from April to November 2017. Materials and Methods: Fifty-four MDR bacterial isolates, namely Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa , and Staphylococcus aureus , were obtained from various clinical samples of inpatients...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29962798/adverse-drug-reactions-attributed-to-fondaparinux-and-unfractionated-heparin-in-cardiovascular-care-unit-an-observational-prospective-pilot-study-in-a-tertiary-care-hospital
#4
Sahithi Sharma, Shubhatara Swamy, Anupam Bhambhani, Pratibha Nadig
Introduction: This study was carried out to collect and analyze the adverse drug reactions (ADRs) reported with use of anticoagulants, heparin and fondaparinux. These drugs are vital in the treatment of unstable coronary artery diseases and emergencies. Materials and Methods: A cross-sectional study with active reporting of ADRs from cardiology and medicine department was conducted. The type of reaction was assessed by Rawlins and Thomson criteria, causality by Naranjo probability scale, severity by modified Hartwig criteria, and preventability by Schumock and Thornton criteria...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29962797/-in-vitro-antilithiatic-potential-of-kalanchoe-pinnata-emblica-officinalis-bambusa-nutans-and-cynodon-dactylon
#5
Atul K Sohgaura, Papiya Bigoniya, B Shrivastava
Objective: The study aims at the exploration of calcium oxalate (CaOx ) crystal growth inhibition potential of Cynodon dactylon , Emblica officinalis , Kalanchoe pinnata , and Bambusa nutans ethyl acetate fraction rich in polyphenol and flavonoid. Materials and Methods: Ethyl acetate fraction was separated from the hydromethanolic extract of C. dactylon , E. officinalis , K. pinnata , and B. nutans followed by quantitative analysis for total polyphenol and flavonoid content...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29962796/assessment-of-knowledge-attitude-and-practice-of-dental-and-medical-interns-toward-toothbrush-maintenance-and-replacement-in-bhubaneswar-city-odisha-india
#6
Gunjan Kumar, Alok Kumar Sethi, Ranjan Mani Tripathi, Pratik, Diplina Barman
Background: Toothbrushes are an important medium for maintaining good oral hygiene, and hence there arises a need to maintain and replace toothbrushes at a regular interval. Assessing the knowledge, attitude, and practice (KAP) of the medical and dental interns would help the society in promoting oral hygiene in a broader aspect. Materials and Methods: A cross-sectional questionnaire study was conducted among 759 medical and dental interns residing in Bhubaneswar, Odisha, India...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29962795/pharmacoepidemiological-observational-study-of-antimicrobial-use-in-outpatients-of-ophthalmology-department-in-north-indian-population
#7
Hina Kauser, Deepti Chopra, Shoma Mukherjee, Pooja Mohan
Background: Recognition of drug usage patterns provides the basis for improving safety and plummeting risks associated with their use. Thus, this study was undertaken to explore the drug usage pattern in ophthalmology with an emphasis on antimicrobial use at a tertiary care teaching hospital. Materials and Methods: An observational study was conducted in the Department of Ophthalmology, Hakeem Abdul Hameed Centenary Hospital, Jamia Hamdard, New Delhi, India for 9 months...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29962794/protective-effect-of-rheum-turkestanicum-against-cisplatin-by-reducing-oxidative-stress-in-kidney-tissue
#8
Azar Hosseini, Sahar Fanoudi, Hamid Mollazadeh, Azita Aghaei, Mohammad Taher Boroushaki
Background: Cisplatin is used as chemotherapeutic drug in the treatment of some solid tumors. It causes different side effects such as nephrotoxicity because of increasing oxidative stress and reactive oxygen species production. This study was designed to investigate the effect of Rheum turkestanicum on cisplatin-induced nephrotoxicity in rat. Materials and Methods: Animals were randomly divided into four groups (six each). Group I received normal saline (1mL/day, intraperitoneally [i...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29962793/electrochemical-oxidability-of-antioxidants-synergism-and-antagonism-in-mixes
#9
Natalia Sazhina, Evgenii Plotnikov, Elena Korotkova, Elena Dorozhko, Olesya Voronova
Aims: To investigate electrochemical oxidability of antioxidants to reveal synergistic and antagonistic effects in mixes. Materials and Methods: Electrochemical oxidability of some widely used antioxidants, including uric acid, glutathione, trolox, ascorbic acid, gallic acid, Mexidol, and potassium fenozan, was investigated by the amperometric approach. Results: All obtained electrochemical oxidability values correlate well with antioxidant activity parameters of the same compounds measured by other methods...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29962792/polycystic-ovarian-syndrome-related-depression-in-adolescent-girls-a-review
#10
Saleha Sadeeqa, Tehreem Mustafa, Sumaira Latif
Polycystic ovarian syndrome (PCOS), a common endocrinal disorder of reproductive age characterized by heterogeneous complications, is nowadays prevailing among females at adolescent stage. Infrequent or prolonged menstrual periods, excess hair growth, acne, and obesity can occur in women with PCOS. In adolescents, infrequent or absence of menstruation may raise chances for this condition. The increased prevalence of PCOS among general population throughout the world is found to be 5%-10% in the women of reproductive age, and about 40% women with PCOS experience depression, particularly young girls...
April 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29657508/hypnotic-effect-of-red-cabbage-brassica-oleracea-on-pentobarbital-induced-sleep-in-mice
#11
Azar Hosseini, Mohammad-Ali Sobhanifar, Fatemeh Forouzanfar, Azita Aghaee, Hassan Rakhshandeh
Objective: The present study was performed to investigate the effect of hydroalcoholic extract of red cabbage and its fractions on sleeping behavior in mice. Materials and Methods: The extract and its fractions were injected to mice and sleep duration as well as sleep latency were recorded. Furthermore, toxicity of the extract was determined both in vivo and in vitro . Results: The extract increased sleep duration at doses of 50-200mg/kg ( P < 0...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29657507/initial-response-of-human-bone-marrow-derived-stem-cells-after-contact-with-ultrahigh-molecular-weight-polyethylene-uhmwpe-material-an-in-vitro-study-on-cell-viability-and-interleukin-6-expression
#12
Iwan B Anwar, Asep Santoso, Eko Saputra, Rifky Ismail, J Jamari, Emile van der Heide
Introduction: Ultrahigh-molecular-weight polyethylene (UHMWPE) is a thermoplastic polymer useful in biomaterial applications, especially in orthopedic field. Yet, little is known concerning its initial effect on human bone marrow stem cells (hBMSCs) after implantation. Materials and Methods: A cytotoxicity analysis was performed with a 3-(4,5-dimethylthiazol 2-yl)-2,5-diphenyltetrazolium assay after 24, 48, and 72h of incubation of hBMSC culture. Expression of interleukin-6 (IL-6) was measured using enzyme-linked immunosorbent assay...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29657506/-in-vivo-evaluation-of-the-anticancer-activity-of-the-gemcitabine-and-doxorubicin-combined-in-a-nanoemulsion
#13
Mayson H Alkhatib, Wafa S Alshehri, Faiza B Abdu
Context: Doxorubicin (DOX) and gemcitabine (GEM) are anticancer drugs that were combined in a nanoemulsion (NE) to reduce their adverse side effects. Aim: To detect the antitumor activity of the combination formulas of GEM and DOX, loaded either in water (GEM+DOX-Sol) or in NEs (GEM-DOX combination/loaded NE [GEM+DOX/LNE]), in female Swiss albino mice inoculated with Ehrlich ascites carcinoma (EAC). Settings and Design: The anticancer assessment of the NE formulas was implemented in 200 mice, which were divided into 10 groups...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29657505/knowledge-and-attitude-of-health-care-professionals-toward-adverse-drug-reactions-reporting-at-king-saud-medical-city
#14
Khaja Moinuddin, Sheraz Ali, Amal Qadri Al-Aqqad, Sara Osama Salem, Maram Abdullah Al-Dossari, Abdullah Mohammad Ananzeh, Jaffer Bin Baqar
Background: Health-care professionals across the globe are obligated to report adverse drug reactions (ADRs). The knowledge of ADRs and attitude of health-care professionals toward ADRs reporting is vital for patient safety. This study intends to investigate the knowledge of ADRs and attitude of health-care professionals toward ADRs reporting. Materials and Methods: A cross-sectional study using an anonymous questionnaire was conducted over a period of 3 months (September 2016 to November 2016) at King Saud Medical City, Riyadh, Saudi Arabia...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29657504/safety-evaluation-of-various-vector-repellents-in-combination-with-deltamethrin-in-wistar-rats
#15
Anitha Magesh, Senthilkumar Sivanesan, Vijayaraghavan Rajagopalan, Royapuram Veeraragavan Geetha, Anitha Roy
Background: Vector repellents are used globally to avoid insect bites and control transmission of diseases. It is important to ensure safety levels of these compounds, although they are noxious to insects. Vector repellents when used in combination are known to bring additional benefits in getting rid of the harmful insects. Unfortunately, the safety levels of various vector repellents such as Deet ( N , N -diethyl- m -toluamide), Depa ( N , N -diethyl phenylacetamide), and Deb ( N , N -diethylbenzamide) are not studied in combination with the widely used pyrethroid deltamethrin (Del)...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29657503/phytochemical-constituents-and-antimicrobial-activity-of-the-ethanol-and-chloroform-crude-leaf-extracts-of-spathiphyllum-cannifolium-dryand-ex-sims-schott
#16
Arunachalam Dhayalan, Daniel E Gracilla, Renato A Dela Peña, Marilyn T Malison, Christian R Pangilinan
Context: The study investigated the medicinal properties of Spathiphyllum cannifolium (Dryand. ex Sims) Schott as a possible source of antimicrobial compounds. Materials and Methods: The phytochemical constituents were screened using qualitative methods and the antibacterial and antifungal activities were determined using agar well diffusion method. Statistical Analysis: One-way analysis of variance and Fisher's least significant difference test were used...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29657502/knowledge-attitude-and-practice-regarding-the-risk-of-cardiovascular-diseases-in-patients-attending-outpatient-clinic-in-kuantan-malaysia
#17
Nursyafiza B Mohammad, Nor Azlina A Rahman, Mainul Haque
Background: Cardiovascular disease (CVD) is a leading cause of death around the world including Malaysia. Ischemic heart disease (IHD) is the single largest cause of death in the developed countries and is one of the main contributors to the disease burden in developing countries. Materials and Methods: This was a cross-sectional study conducted to determine knowledge, attitude, and practice (KAP) regarding the risk of CVD in patients attending an outpatient clinic in Kuantan, Malaysia...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29657501/evaluation-of-bloodletting-cupping-therapy-in-the-management-of-hypertension
#18
Moawia M Al-Tabakha, Farah Tariq Sameer, Mai Hafiz Saeed, Rahaf Montaser Batran, Nada Tarek Abouhegazy, Alaa A Farajallah
Background: Bloodletting cupping therapy (Hijama) is a traditional alternative medicine practiced in different cultures. Claims about the therapeutic efficacy of Hijama in hypertension are contradictory. The aim of this project was to determine if Hijama therapy is beneficial in the treatment of patients with hypertension. Materials and Methods: In this retrospective study, 60 files for patients treated for hypertension, aged 40-60 years and whose systolic blood pressure (SBP) is at least 140mm Hg, were used...
January 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284986/management-of-tooth-surface-loss-of-varying-etiology-with-full-mouth-all-ceramic-computer-aided-design-computer-aided-manufacture-restorations
#19
Nirmal Famila Bettie, Saravanan Kandasamy, Venkat Prasad
The anatomical form of a tooth can undergo changes leading to loss of tooth form. The loss of tooth surface can be due to varying etiology. Dental caries, attrition, abrasion, erosion, involving any surface of the tooth can lead to loss of tooth structure. The rate of tooth destruction may proceed to such an extent that the esthetics, function and comfort may be lost. The role of a practioner lies in identification and screening of such case and motivate for oral rehabilitation that includes habit cessation...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284985/a-conservative-method-of-retaining-an-interim-obturator-for-a-total-maxillectomy-patient
#20
Nirmal Famila Bettie
Interim obturators are indicated during the postsurgical phases. It promotes surgical healing and serves as a temporary prosthesis to rehabilitate a patient with intra-oral surgical defect. Retention is gained by wiring, surgical suturing, and other noninvasive methods to enable functional rehabilitation and easy replacement with a permanent obturator. Interim obturators serve as an easy guide for replacing with definitive obturators by indicating prosthesis extensions and the required method of retention. A more conservative and noninvasive method of retaining an interim obturator for a maxillectomy patient is described in this case report...
November 2017: Journal of Pharmacy & Bioallied Sciences
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