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Journal of Pharmacy & Bioallied Sciences

Mohsen Keshavarz, Mohammad Hadi Karbalaie Niya, Fahimeh Safarnezhad Tameshkel, Amir Sasan Mozaffari Nejad, Seyed Hamidreza Monavari, Hossein Keyvani
Background: Xenotropic murine leukemia virus-related virus (XMRV) is a gamma retrovirus, which has been detected in patients with prostate cancer, chronic fatigue syndrome, and general population with a number of acquired infections such as infection with human T-cell lymphotropic virus (HTLV) and human immunodeficiency virus (HIV). The aim of this study was to determine the HTLV-1 and XMRV coinfection for the first time in Iranian patients who were admitted to the Tehran hospitals. Materials and Methods: Two hundred and ninety one patients suspected with HTLV-1 were referred to the hospitals affiliated to the Iran University of Medical Sciences, Tehran, Iran from April 2012 to October 2016...
July 2018: Journal of Pharmacy & Bioallied Sciences
Hanine Almubayedh, Rizwan Ahmad, Atta A Naqvi, Niyaz Ahmad
Background: Cinnamon ( Cinnamomum zeylanicum ) is a herb that is used traditionally as a flavoring agent as well as for its health benefits in different parts of the world. Its use may vary among cultures. Aim: To observe the knowledge and uses regarding cinnamon in the Saudi population. Materials and Methods: A 2-month cross-sectional study was conducted in Khobar, Saudi Arabia, using a novel questionnaire in Arabic language. Results: A total of 585 responses were collected...
July 2018: Journal of Pharmacy & Bioallied Sciences
Mohd Akhtar Ali, Hamiduddin, Mohammad Zaigham, Mohammad Ikram, Rajeev Ranjan
Introduction: Kushta of Shangarf (KS) is in therapeutic use since long time in Unani and Ayurvedic medicine. It requires extensive assessment with respect to its safety and processing because of the presence of mercury. KS prepared with Shangarf (HgS), Phitkari (alum), and Jozbua ( Myristica fragrans Houtt.) was selected for the study. It is indicated as tonic, increases blood production, and improves complexion of face. Preparation of KS by classical and contemporary method and its comparative physicochemical analysis was attempted in this work...
July 2018: Journal of Pharmacy & Bioallied Sciences
Bashir A Yousef, Amina I Dirar, Mohamed Ahmed A Elbadawi, Mohamed K Awadalla, Magdi A Mohamed
Background: Plants of the Amaryllidaceae family have been under intense scrutiny for the presence of a couple of alkaloidal secondary metabolites with endued cytotoxic activity, such as pancratistatin ( 1 ), 7-deoxypancratistatin ( 2 ), narciclasine ( 3 ), 7-deoxynarciclasine ( 4 ), trans -dihydronarciclasine ( 5 ), and 7-deoxy- trans -dihydronarciclasine ( 6 ). Nevertheless, preclinical evaluation of these alkaloids has been put on hold because of the limited quantity of materials available from isolation...
July 2018: Journal of Pharmacy & Bioallied Sciences
Harshad O Malve
Abuse of substances or methods to enhance the performance is becoming very common in the sports, which often destroys the spirit of competition. The regulatory bodies for sports have reported rates ranging from 5% to 31% for the use of performance-enhancing substances among athletes. Athletes can have serious injuries and morbidities, leading to poor health with the use of such substances. Commonly abused agents in sports include anabolic-androgenic steroids and its analogs, blood, erythropoietin, growth hormone and its derivatives, nutritional supplements, creatine, amphetamines, beta-hydroxy-beta-methylbutyrate (HMB), stimulants, and analgesics...
July 2018: Journal of Pharmacy & Bioallied Sciences
Nallan Csk Chaitanya, Arvind Muthukrishnan, C M S Krishnaprasad, Gali Sanjuprasanna, Poojaragini Pillay, Balmoori Mounika
Pain is an unpleasant subjective feeling having implications on both physical and mental realm. Multiple dimensions of pain involving behavioral, spiritual, emotional, and cognitive changes have been studied and pathways elucidated. It is stressed that the nature in which pain is modulated and perceived at a higher center is a complex phenomenon. One of the main goals of pain modulation is to modify pain to a more tolerable level, rather than its complete eradication. Different pain management interventions were tried but have effects that are more adverse...
July 2018: Journal of Pharmacy & Bioallied Sciences
Kamran Ashraf, Sadia Sultan, Aishah Adam
Orthosiphon stamineus Benth. (Lamiaceae) is a valued medicinal plant in traditional folk medicine. Many pharmacological studies have demonstrated the ability of this plant to exhibit antimicrobial, antioxidant, hepatoprotection, antigenotoxic, antiplasmodial, cytotoxic, cardioactive, antidiabetic, anti-inflammatory activies. This review is a comprehensive summary of the presently available chemical, pharmacological investigations as well as the traditional and therapeutic uses of this plant. Important and different experimental data have been addressed along with a review of all phytochemicals identified in this plant, including flavonoids, terpenoids, and essential oils...
July 2018: Journal of Pharmacy & Bioallied Sciences
Gibson S T Daniel, Manigandan Thiruppathy, Nalini Aswath, Sankar R Narayanan
Oral cancer is the fifth most common cancer in the world, accounting for numerous deaths annually. The 5-year survival rate remains approximately 50% for oral squamous cell carcinoma (OSCC) in the past several decades. Early detection plays a vital role in the survival rate of the patients. There is no accurate, cost-effective, and reliable method for the screening of patients with OSCC. Hence, many patients are diagnosed at advanced stages. Early detection would, therefore, help to identify patients and modify treatment with close monitoring...
April 2018: Journal of Pharmacy & Bioallied Sciences
Pratima Gupta, Ruchi Dua, Mohit Bhatia, Puneet K Gupta, Neelam Kaistha
Strongyloides stercoralis is a soil-transmitted helminth that occurs almost worldwide, yet estimates about its prevalence are not well documented. The spectrum of clinical manifestations of strongyloidiasis is wide, ranging from asymptomatic disease to hyperinfection or dissemination of larvae involving multiple organ systems. Immunosuppression can increase the risk of hyperinfection syndrome in patients with strongyloidiasis. Strongyloidiasis continues to remain a neglected tropical disease, the diagnosis of which is often overlooked by clinicians and diagnosticians alike...
April 2018: Journal of Pharmacy & Bioallied Sciences
Priyanka Gupta, Mohit Bhatia, Pratima Gupta, Balram J Omar
Context: Possible linkage between biocide and antibiotic resistance in bacteria is a major area of concern. Aim: To evaluate the susceptibility of multidrug-resistant (MDR) bacteria to four commonly used biocides. Settings and Design: A pilot study was conducted in a tertiary care hospital from April to November 2017. Materials and Methods: Fifty-four MDR bacterial isolates, namely Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa , and Staphylococcus aureus , were obtained from various clinical samples of inpatients...
April 2018: Journal of Pharmacy & Bioallied Sciences
Sahithi Sharma, Shubhatara Swamy, Anupam Bhambhani, Pratibha Nadig
Introduction: This study was carried out to collect and analyze the adverse drug reactions (ADRs) reported with use of anticoagulants, heparin and fondaparinux. These drugs are vital in the treatment of unstable coronary artery diseases and emergencies. Materials and Methods: A cross-sectional study with active reporting of ADRs from cardiology and medicine department was conducted. The type of reaction was assessed by Rawlins and Thomson criteria, causality by Naranjo probability scale, severity by modified Hartwig criteria, and preventability by Schumock and Thornton criteria...
April 2018: Journal of Pharmacy & Bioallied Sciences
Atul K Sohgaura, Papiya Bigoniya, B Shrivastava
Objective: The study aims at the exploration of calcium oxalate (CaOx ) crystal growth inhibition potential of Cynodon dactylon , Emblica officinalis , Kalanchoe pinnata , and Bambusa nutans ethyl acetate fraction rich in polyphenol and flavonoid. Materials and Methods: Ethyl acetate fraction was separated from the hydromethanolic extract of C. dactylon , E. officinalis , K. pinnata , and B. nutans followed by quantitative analysis for total polyphenol and flavonoid content...
April 2018: Journal of Pharmacy & Bioallied Sciences
Gunjan Kumar, Alok Kumar Sethi, Ranjan Mani Tripathi, Pratik, Diplina Barman
Background: Toothbrushes are an important medium for maintaining good oral hygiene, and hence there arises a need to maintain and replace toothbrushes at a regular interval. Assessing the knowledge, attitude, and practice (KAP) of the medical and dental interns would help the society in promoting oral hygiene in a broader aspect. Materials and Methods: A cross-sectional questionnaire study was conducted among 759 medical and dental interns residing in Bhubaneswar, Odisha, India...
April 2018: Journal of Pharmacy & Bioallied Sciences
Hina Kauser, Deepti Chopra, Shoma Mukherjee, Pooja Mohan
Background: Recognition of drug usage patterns provides the basis for improving safety and plummeting risks associated with their use. Thus, this study was undertaken to explore the drug usage pattern in ophthalmology with an emphasis on antimicrobial use at a tertiary care teaching hospital. Materials and Methods: An observational study was conducted in the Department of Ophthalmology, Hakeem Abdul Hameed Centenary Hospital, Jamia Hamdard, New Delhi, India for 9 months...
April 2018: Journal of Pharmacy & Bioallied Sciences
Azar Hosseini, Sahar Fanoudi, Hamid Mollazadeh, Azita Aghaei, Mohammad Taher Boroushaki
Background: Cisplatin is used as chemotherapeutic drug in the treatment of some solid tumors. It causes different side effects such as nephrotoxicity because of increasing oxidative stress and reactive oxygen species production. This study was designed to investigate the effect of Rheum turkestanicum on cisplatin-induced nephrotoxicity in rat. Materials and Methods: Animals were randomly divided into four groups (six each). Group I received normal saline (1mL/day, intraperitoneally [i...
April 2018: Journal of Pharmacy & Bioallied Sciences
Natalia Sazhina, Evgenii Plotnikov, Elena Korotkova, Elena Dorozhko, Olesya Voronova
Aims: To investigate electrochemical oxidability of antioxidants to reveal synergistic and antagonistic effects in mixes. Materials and Methods: Electrochemical oxidability of some widely used antioxidants, including uric acid, glutathione, trolox, ascorbic acid, gallic acid, Mexidol, and potassium fenozan, was investigated by the amperometric approach. Results: All obtained electrochemical oxidability values correlate well with antioxidant activity parameters of the same compounds measured by other methods...
April 2018: Journal of Pharmacy & Bioallied Sciences
Saleha Sadeeqa, Tehreem Mustafa, Sumaira Latif
Polycystic ovarian syndrome (PCOS), a common endocrinal disorder of reproductive age characterized by heterogeneous complications, is nowadays prevailing among females at adolescent stage. Infrequent or prolonged menstrual periods, excess hair growth, acne, and obesity can occur in women with PCOS. In adolescents, infrequent or absence of menstruation may raise chances for this condition. The increased prevalence of PCOS among general population throughout the world is found to be 5%-10% in the women of reproductive age, and about 40% women with PCOS experience depression, particularly young girls...
April 2018: Journal of Pharmacy & Bioallied Sciences
Azar Hosseini, Mohammad-Ali Sobhanifar, Fatemeh Forouzanfar, Azita Aghaee, Hassan Rakhshandeh
Objective: The present study was performed to investigate the effect of hydroalcoholic extract of red cabbage and its fractions on sleeping behavior in mice. Materials and Methods: The extract and its fractions were injected to mice and sleep duration as well as sleep latency were recorded. Furthermore, toxicity of the extract was determined both in vivo and in vitro . Results: The extract increased sleep duration at doses of 50-200mg/kg ( P < 0...
January 2018: Journal of Pharmacy & Bioallied Sciences
Iwan B Anwar, Asep Santoso, Eko Saputra, Rifky Ismail, J Jamari, Emile van der Heide
Introduction: Ultrahigh-molecular-weight polyethylene (UHMWPE) is a thermoplastic polymer useful in biomaterial applications, especially in orthopedic field. Yet, little is known concerning its initial effect on human bone marrow stem cells (hBMSCs) after implantation. Materials and Methods: A cytotoxicity analysis was performed with a 3-(4,5-dimethylthiazol 2-yl)-2,5-diphenyltetrazolium assay after 24, 48, and 72h of incubation of hBMSC culture. Expression of interleukin-6 (IL-6) was measured using enzyme-linked immunosorbent assay...
January 2018: Journal of Pharmacy & Bioallied Sciences
Mayson H Alkhatib, Wafa S Alshehri, Faiza B Abdu
Context: Doxorubicin (DOX) and gemcitabine (GEM) are anticancer drugs that were combined in a nanoemulsion (NE) to reduce their adverse side effects. Aim: To detect the antitumor activity of the combination formulas of GEM and DOX, loaded either in water (GEM+DOX-Sol) or in NEs (GEM-DOX combination/loaded NE [GEM+DOX/LNE]), in female Swiss albino mice inoculated with Ehrlich ascites carcinoma (EAC). Settings and Design: The anticancer assessment of the NE formulas was implemented in 200 mice, which were divided into 10 groups...
January 2018: Journal of Pharmacy & Bioallied Sciences
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