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Journal of Pharmacy & Bioallied Sciences

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https://www.readbyqxmd.com/read/28584496/marfan-syndrome
#1
T Sivasankari, Philips Mathew, Ravi David Austin, Sakthi Devi
Marfan syndrome (MFS) is the autosomal dominant-inherited multisystem connective-tissue disorder, with a reported incidence of 1 in 10,000 individuals and equal distribution in both genders. The main clinical manifestation of this disorder consists of an exaggerated length of the upper and lower limbs, hyperlaxity, scoliosis, alterations in the cardiovascular and pulmonary systems, and atypical bone overgrowth. Orofacial manifestations such as high-arched palate, hypodontia, long narrow teeth, bifid uvula, mandibular prognathism, and temporomandibular disorders are also common...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584495/prevalence-pattern-and-correlates-of-alcohol-misuse-among-male-patients-attending-rural-primary-care-in-india
#2
Sanghamitra Pati, Subhashisa Swain, Sandeep Mahapatra, Mohammad Akhtar Hussain, Sandipana Pati
BACKGROUND: There are limited data available on how the problem of alcohol use is detected in primary care setting in India. Particularly in Odisha, it has not been investigated yet. This study was conducted to determine the prevalence of drinking, drinking patterns, and quitting behavior among the male patients visiting a primary health-care facility in a district of Odisha. METHODOLOGY: A cross-sectional study was conducted among patients attending community health center (CHC), Buguda in the state of Odisha, India, from December 1, 2014, to February 31, 2015...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584494/efficacy-and-tolerability-of-antihypertensive-drugs-in-diabetic-and-nondiabetic-patients
#3
Maria Aslam, Mobasher Ahmad, Fizza Mobasher
OBJECTIVES OF THE STUDY: The aim of the study was to compare the efficacy and tolerability of different classes of antihypertensive drugs in diabetic and nondiabetic patients (NDPs) with essential hypertension. MATERIAL AND METHODS: The study was conducted in Mayo Hospital, Punjab Institute of Cardiology, and National Defence Hospital, Lahore, Pakistan, on 200 hypertensive patients with diabetes and 230 hypertensive patients without (Three hospitals) diabetes. Both male and female patients of age between 30 and 80 years with systolic blood pressure (SBP) above 130 mmHg and diastolic blood pressure (DBP) above 80 mmHg were enrolled in the study...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584493/assessment-of-perception-experience-and-information-seeking-behavior-of-the-public-of-ras-al-khaimah-united-arab-emirates-toward-usage-and-safety-of-complementary-and-alternative-medicine
#4
Sathvik Belagodu Sridhar, Atiqulla Shariff, Nour Al Halabi, Rand Sarmini, Lubab Arkan Harb
AIMS AND OBJECTIVES: This study was conducted to identify the different types of complementary and alternative medicine (CAM) used, reasons for the use of CAM, and the perceptions, experience, and information seeking-behavior toward usage and safety of CAM by the general public of Ras Al-Khaimah, UAE. MATERIALS AND METHODS: This was a prospective cross-sectional study. A validated, self-administered, or interviewer-assisted survey questionnaire was used to collect the data...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584492/prevalence-of-exposure-to-secondhand-smoke-among-higher-secondary-school-students-in-ernakulam-district-kerala-southern-india
#5
P S Rakesh, Jishnu Satheesh Lalu, K Leelamoni
INTRODUCTION: The association between secondhand smoke and health outcomes, such as frequent respiratory infections, ischemic heart disease, lung cancer, asthma, and stroke, has long been established. The study aimed to estimate the prevalence of secondhand smoking exposure among higher secondary school students in Ernakulam district, Kerala, Southern India. MATERIALS AND METHODS: A structured questionnaire was administered to all students from four randomly selected higher secondary schools in Ernakulam district...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584491/evaluation-of-cassia-tora-linn-against-oxidative-stress-induced-dna-and-cell-membrane-damage
#6
R Sunil Kumar, Ramesh Balenahalli Narasingappa, Chandrashekar G Joshi, Talakatta K Girish, Ummiti Js Prasada Rao, Ananda Danagoudar
OBJECTIVE: The present study aims to evaluate antioxidants and protective role of Cassia tora Linn. against oxidative stress-induced DNA and cell membrane damage. MATERIALS AND METHODS: The total and profiles of flavonoids were identified and quantified through reversed-phase high-performance liquid chromatography. In vitro antioxidant activity was determined using standard antioxidant assays. The protective role of C. tora extracts against oxidative stress-induced DNA and cell membrane damage was examined by electrophoretic and scanning electron microscopic studies, respectively...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584490/chromatographic-isolation-and-spectroscopic-identification-of-phytoconstituents-of-jujuba-seeds-zizyphus-jujuba-mill
#7
Md Manowwar Alam, Abuzer Ali, Mohammad Ali, Showkat R Mir
BACKGROUND: The seeds of Zizyphus jujuba Mill. (Rhamnaceae) are astringent, aphrodisiac, tonic; used to cure cough, asthma, vomiting, burning sensation, biliousness, leucorrhoea, and eye infections in traditional systems of medicine. MATERIALS AND METHODS: The methanol extract of seeds of Z. jujuba was partitioned into petroleum ether and water soluble fractions. Isolation of compounds was performed by silica gel column chromatography. The structures of isolated compounds were established on the basis of spectral studies and chemical reactions...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584489/influence-of-milling-process-on-efavirenz-solubility
#8
Erizal Zaini, Deni Wahyu, Maria Dona Octavia, Lili Fitriani
INTRODUCTION: The aim of this study was to investigate the influence of the milling process on the solubility of efavirenz. MATERIALS AND METHODS: Milling process was done using Nanomilling for 30, 60, and 180 min. Intact and milled efavirenz were characterized by powder X-ray diffraction, scanning electron microscopy (SEM), spectroscopy infrared (IR), differential scanning calorimetry (DSC), and solubility test. RESULTS: The X-ray diffractogram showed a decline on peak intensity of milled efavirenz compared to intact efavirenz...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584488/moisture-sorption-desorption-characteristics-and-the-corresponding-thermodynamic-properties-of-carvedilol-phosphate
#9
Ravikiran Allada, Arthanareeswari Maruthapillai, Kamaraj Palanisamy, Praveen Chappa
AIMS: Carvedilol phosphate (CDP) is a nonselective beta-blocker used for the treatment of heart failures and hypertension. In this work, moisture sorption-desorption characteristics and thermodynamic properties of CDP have been investigated. MATERIALS AND METHODS: The isotherms were determined using dynamic vapor sorption analyzer at different humidity conditions (0%-90% relative humidity) and three pharmaceutically relevant temperatures (20°C, 30°C, and 40°C)...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584487/modulatory-effects-of-decalepis-hamiltonii-extract-and-its-compounds-on-the-antioxidant-status-of-the-aging-rat-brain
#10
Ramachandregowda Sowbhagya, Siddhaghatta Kariyappa Anupama, Dundaiah Bhagyalakshmi, Santosh Anand, Tekupalli Ravikiran
OBJECTIVE: The present study was aimed to investigate the neuroprotective effects of Decalepis hamiltonii (Dh) aqueous root extract and its compounds against age-related oxidative stress (OS) in the discrete regions of the rat brain. MATERIALS AND METHODS: Male Wistar albino rats of 4- and 22-month-old were divided into control and six supplemented groups. The supplemented groups were orally administered with ellagic acid (EA), 4-hydroxyisophthalic acid (4-HIA), and Dh extract for 30 days...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28584486/estimation-of-guggulsterone-e-and-z-in-the-guggul-based-commercial-formulations-using-high-performance-thin-layer-chromatography
#11
Pramod Kumar Sairkar, Anjana Sharma, N P Shukla
BACKGROUND: Guggulsterone (GS) is a plant steroid and bioactive compound present in gum Guggul of Commiphora wightii. An Indian herbal medicine system "Ayurveda" has a long history of use of gum Guggul and plant extract of C. wightii as medicine for the treatment of various illnesses. Complex nature, low availability, and inconsistency of phytoconstituents make its analysis of difficult tasks. AIMS: In this work, six different Guggul-based herbal formulations were examined for estimation of GS and their isomers (E and Z) through high-performance thin-layer chromatography technique...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28216962/electronic-cigarette-experimentation-in-the-malaysian-city-of-kuantan-was-there-an-association-with-the-smoking-status
#12
Konstantinos E Farsalinos, Jacques Le Houezec
No abstract text is available yet for this article.
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28216961/menopausal-symptoms-and-obesity-is-there-a-relationship
#13
Maria Fernanda Naufel, Cristina Frange, Sérgio Tufik, Helena Hachul
No abstract text is available yet for this article.
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28216960/pharmacological-evaluation-of-apium-leptophyllum-pers-on-bronchial-asthma
#14
Himanshu Bhusan Sahoo, Rakesh Sagar, Ganesh Patro, Madhulita Panda, Saroj Kumar Sahoo, D Priyadarshini
OBJECTIVE: The present study was to investigate the antiasthmatic potential from the flavonoid fraction of Apium leptophyllum fruit (FFALF) to validate its traditional claim. MATERIALS AND METHODS: The antiasthmatic activity of FFALF was evaluated by histamine or acetylcholine-induced bronchospasm model in guinea pigs, compound 48/80 induced mast cell degranulation in albino rats and histamine-induced tracheal contraction in guinea pig. The preconvulsion dyspnea time at 0(th) and 7(th) day at the dose of 100 and 200 mg/kg in guinea pig's bronchospasm model, the percentage of granulated and degranulated mast cell at the dose of 500, 750, and 1000 μg/ml in rats and tracheal contraction at the dose of 500, 750, and 1000 μg/ml in guinea pig were measured and compared with respective control groups...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28216959/prescription-patterns-and-appropriateness-of-antibiotics-in-the-management-of-cough-cold-and-diarrhea-in-a-rural-tertiary-care-teaching-hospital
#15
Akram Ahmad, Muhammad Umair Khan, Sadiqa Malik, Guru Prasad Mohanta, S Parimalakrishnan, Isha Patel, Sameer Dhingra
BACKGROUND: Acute gastroenteritis and respiratory illnesses are the major causes of morbidity and mortality in children under 5 years of age. The objective of this study was to evaluate the prescription pattern of antibiotic utilization during the treatment of cough/cold and/or diarrhea in pediatric patients. METHODS: A descriptive, cross-sectional study was conducted for 6 months in pediatric units of a tertiary care hospital in South India. Children under 5 years of age presenting with illness related to diarrhea and/or cough/cold were included in this study...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28216958/-1-h-nmr-based-serum-metabolomics-reveals-erythromycin-induced-liver-toxicity-in-albino-wistar-rats
#16
Atul Rawat, Durgesh Dubey, Anupam Guleria, Umesh Kumar, Amit K Keshari, Swati Chaturvedi, Anand Prakash, Sudipta Saha, Dinesh Kumar
INTRODUCTION: Erythromycin (ERY) is known to induce hepatic toxicity which mimics other liver diseases. Thus, ERY is often used to produce experimental models of drug-induced liver-toxicity. The serum metabolic profiles can be used to evaluate the liver-toxicity and to further improve the understanding of underlying mechanism. OBJECTIVE: To establish the serum metabolic patterns of Erythromycin induced hepatotoxicity in albino wistar rats using (1)H NMR based serum metabolomics...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28216957/synthesis-of-some-novel-pyrazolo-3-4-d-pyrimidin-4-5h-one-derivatives-as-potential-antimicrobial-agent
#17
Dipen K Sureja, Sandip P Dholakia, Kantilal R Vadalia
OBJECTIVES: The aim of the present work was to synthesize a novel series of pyrazolo[3,4-d]pyrimidin-4(5H)-one derivatives and evaluate their in vitro antimicrobial activity. METHODS: Cyclization of an ortho-amino ester of 1-(2,4-dinitrophenyl)pyrazole with various aliphatic/aromatic nitriles under different reaction conditions such as conventional and microwave assisted synthesis, provided pyrazolo[3,4-d] pyrimidin-4(5H)-one derivatives. All the synthesized compounds were evaluated in vitro for their antimicrobial activity against selected bacteria and fungi by agar well diffusion method...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28216956/assessment-of-cost-of-illness-for-diabetic-patients-in-south-indian-tertiary-care-hospital
#18
Leelavathi D Acharya, N R Rau, N Udupa, M Surulivel Rajan, K Vijayanarayana
BACKGROUND: The impact of diabetes on health-care expenditures has been increasingly recognized. To formulate an effective health planning and resource allocation, it is important to determine economic burden. OBJECTIVE: The objective of this study is to assess the cost of illness (COI) for diabetic inpatients with or without complications. METHODOLOGY: The study was conducted in the medicine wards of tertiary care hospital after ethical approval by the Institutional Ethical Committee...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28216955/patterns-of-prescription-drugs-use-among-pregnant-women-at-sultan-qaboos-university-hospital-and-sultan-qaboos-university-hospital-family-and-community-medicine-clinic-oman
#19
J Z Al-Hamimi, K A Al Balushi
OBJECTIVE: This study evaluates the patterns of prescription drugs use among women attending antenatal clinic at Sultan Qaboos University Hospital (SQUH) and SQUH Family and Community Medicine clinic (FAMCO), Oman. METHODS: The study was a descriptive retrospective cross-sectional study on pregnant women who attended the antenatal clinic at SQUH and FAMCO from February to April 2014 and received a prescription containing at least one drug. Patients' information was extracted from SQUH electronic records...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28216954/optimization-characterization-and-efficacy-evaluation-of-2-chitosan-scaffold-for-tissue-engineering-and-wound-healing
#20
Priyanka Chhabra, Priyanka Tyagi, Aseem Bhatnagar, Gaurav Mittal, Amit Kumar
OBJECTIVE: To develop a chitosan-based scaffold and carry out a complete comprehensive study encompassing optimization of exact chitosan strength, product characterization, toxicity evaluation, in vitro validation in cell culture experiments, and finally in vivo efficacy in animal excision wound model. MATERIALS AND METHODS: Developed chitosan scaffolds (CSs) were optimized for tissue engineering and wound healing efficacy by means of microstructure, toxicity, and biocompatibility evaluation...
October 2016: Journal of Pharmacy & Bioallied Sciences
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