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Journal of Young Pharmacists: JYP

Selvaraj Nitya, Kameswari Deepa, Adhimoolam Mangaiarkkarasi, Kaliaperumal Karthikeyan
Adverse drug reactions are a major hazard of modern medicine. Fixed drug eruption, which is a cutaneous adverse drug reaction, is commonly seen with antimicrobials and analgesics. Here we report 37-year-old female with bullous fixed drug eruptions due to doxycycline administration.
December 2013: Journal of Young Pharmacists: JYP
Jagdish Manwar, Kakasaheb Mahadik, Anant Paradkar, Lohidasan Sathiyanarayanan, Mustafa Vohra, Sanjay Patil
OBJECTIVE: To isolate and characterize the alcohol-producing yeasts from Woodfordia fruticosa flowers, which are used for the induction and maintenance of fermentation in the making of Ayurvedic formulations. MATERIALS AND METHODS: Initially twenty four yeasts strains were isolated on MGYP agar plate. Among them, four strains were selected for further studies on the basis of their alcohol generation capacity using jaggery media (50% w/v). Physiological, biochemical and genetic characterization (18S rRNA sequencing) of selected strains were carried out...
December 2013: Journal of Young Pharmacists: JYP
Teógenes M Souza, Maria F B Morais-Braga, José G M Costa, Antônio A F Saraiva, Micheline A Lima, Henrique D M Coutinho
AIMS: In this work, the ethyl acetate and hexane fractions of Pityrogramma calomelanos (L.) were evaluated to antibacterial and antifungal activity against strains of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, Candida krusei and Candida tropicalis. METHODS: The study was performed aiming to assess the antimicrobial effect with the method of dilution in HIA. The hexane and ethyl acetate fractions were named HFPC and EAFPC, respectively...
December 2013: Journal of Young Pharmacists: JYP
Arti Gupta, Navin R Sheth, Sonia Pandey, Dinesh R Shah, Jitendra S Yadav
AIM: To isolate and identify the quercetin from polyherbal hepatoprotective formulation. Polyherbal formulations were developed by using five bioactive fractionated extracts of Butea monosperma, Bauhinia variegata and Ocimum gratissimum for treatment of liver disorders by exploiting the knowledge of traditional system of medicine and evaluated for hepatoprotective activity using acute liver toxicity model of paracetamol induced liver damage in rats. METHODS: Major active fractions were isolated by solvent fractionation and quantified by HPTLC method...
December 2013: Journal of Young Pharmacists: JYP
Md Rezaul Islam, Aubhishek Zaman, Iffat Jahan, Rajib Chakravorty, Sajib Chakraborty
UNLABELLED: Acetylcholine-esterase (AchE) inhibitors are one of the most potent drug molecules against Alzheimer's disease (AD). But, patients treated with current AchE inhibitors often experience severe side effects. Quercetin is a plant flavonoid compound which can act as AchE inhibitor and it may be a better alternative to current AchE inhibitors in terms of effectiveness with no or fewer side effects. AIMS: The aim of the study was to compare quercetin with conventional AchE inhibitors to search for a better drug candidate...
December 2013: Journal of Young Pharmacists: JYP
Pushkar R Sharma, Shaila A Lewis
AIM: Nateglinide is a quick acting anti-diabetic medication whose potent activity lasts for a short duration. One of the dangerous side effects of nateglinide administration is rapid hypoglycemia, a condition that needs to be monitored carefully to prevent unnecessary fatalities. The aim of the study was to develop a longer lasting and slower releasing formulation of nateglinide that could be administered just once daily. METHODS: Matrix tablets of nateglinide were prepared in combination with the polymers hydroxypropylmethylcellulose (HPMC), eudragits, ethyl cellulose and polyethylene oxide and the formulated drug release patterns were evaluated using in vitro and in vivo studies...
December 2013: Journal of Young Pharmacists: JYP
Sonia Pandey, Ashish Mishra, Pooja Raval, Hetal Patel, Arti Gupta, Dinesh Shah
OBJECTIVE: The objective of present work was to prepare a polyelectrolyte complex (PEC) between chitosan (polycation) & pectin (polyanion) and to develop enteric coated tablets for colon delivery using the PEC. METHODOLOGY: The PECs were prepared using different concentrations of chitosan and pectin. Drug loaded enteric coated tablets were prepared by wet granulation method using PEC to sustain the release at colon and coating was done with Eudragit S 100 to prevent the early release of the drug in stomach and intestine...
December 2013: Journal of Young Pharmacists: JYP
Sekar Vinoth Kumar, Mohan Raj Subramanian, Santhosh Kumar Chinnaiyan
RATIONALE: Benzimidazoles and its derivatives represent one of the mainly biological active classes of literature. AIM: In this present study aimed to synthesize N-mannich bases derivatives compounds bearing of 2-substituted benzimidazole moiety, in order to investigate their possible biological activity. METHOD: Benzimidazole compounds were prepared from the condensation reaction between ortho phenylene diamine and various acids. Mannich base of newly synthesized Benzimidazole derivatives were synthesized from 2-substituted Benzimidazoles by reacting with secondary amines...
December 2013: Journal of Young Pharmacists: JYP
Sumanta Kumar Goswami, Mohammed Naseeruddin Inamdar, Rohitash Jamwal, Shekhar Dethe
OBJECTIVE: Cinnamomum cassia has been suggested in Ayurveda for the management of sexual dysfunction. This research work was conducted to shed some light on the mechanism of action of the extract, and evaluate the efficacy of its methanol extract in age induced sexual dysfunction in male Wistar rats. Secondary objective of the project was to study the effect of treatment on sperm parameters and smooth muscle:collagen level in rat penile tissue. METHODS: Young and aged male rats were treated with methanol extract of Cinnamomum cassia at a dose of 100 mg/kg and sexual behavior was observed on 28th day in presence of female rats in estrous phase...
December 2013: Journal of Young Pharmacists: JYP
Sirajudeen S Alavudeen, C K Dhanapal, Noohu Abdulla Khan, Khalid M Al Akhali, Sam Daniel Paulliah
BACKGROUND/AIM: Dyslipidemia is a significant predictor of cardiovascular events and mortality in diabetes patients. The aim of this study is to estimate the prevalence rates, characteristics of dyslipidemia and their control in outpatient population in a Diabetic Centre. METHODS: A cross sectional prospective study design was used to collect data from 255 patients which included patient characteristics, past medical history of CVD, medications and parameters related to DM and cardiovascular risk factor control...
December 2013: Journal of Young Pharmacists: JYP
Sunita Shailajan, Priyanka Wadke, Harshvardhan Joshi, Bhavesh Tiwari
BACKGROUND: Infestation with the head louse, Pediculus humanus capitis, is one of the most common parasitic infestations of human worldwide. Traditionally, the main treatment for control of head lice is chemical control that includes wide variety of neurotoxic synthetic insecticides. The main difficulty posed in controlling the head louse infestation is increasing lice resistance to synthetic pediculicidal drugs. Plant-based drugs; especially essential oil components and standardized extracts have been suggested as an alternative source of materials for insect control...
December 2013: Journal of Young Pharmacists: JYP
Om Prakash Ranjan, Usha Y Nayak, Meka Sreenivasa Reddy, Swapnil J Dengale, Prashant B Musmade, Nayanabhirama Udupa
OBJECTIVE: To develop a liquid-liquid extraction based reverse phase liquid chromatography method for estimation of montelukast in rabbit plasma. METHODS: Chromatographic separation was carried out using Phenomenex Luna C18 column (250 mm × 4.6 mm × 5 μm) with mobile phase composed of ammonium acetate buffer (20 Mm), pH 5.5 and acetonitrile in 20:80, v/v ratio. The analyte was monitored with UV detector at 345 nm. The developed method was validated with respect to linearity, accuracy, precision, specificity and stability...
December 2013: Journal of Young Pharmacists: JYP
Pavan Kommavarapu, Arthanareeswari Maruthapillai, Ravikiran Allada, Kamaraj Palanisamy, Praveen Chappa
OBJECTIVE: In the present study, simultaneous determination of degree of crystallinity content in abacavir (ABC), lamivudine (3TC) and neverapine (NVP) from there combination drug product using X-ray powder diffraction (XRPD) technique is developed and validated. METHODS: The X-ray procedure for the identification and determination of the degree of crystallinity in ABC, 3TC and NVP drug product is developed and validated. It is based on the X-ray diffraction from crystalline region of the drug product...
December 2013: Journal of Young Pharmacists: JYP
Kothagorla Venkata Raghava Rao, Tamanam Raghava Rao
OBJECTIVE: To isolate and identify the biologically active strain of Streptomyces species from mangrove soil of Visakhapatnam region. MATERIALS AND METHODS: Actinomycetes are isolated by using starch casein agar media and four potential strains were selected to evaluate the antioxidant activity by using the standard methods DPPH, FRAP and total antioxidant capacity. Further, significant antioxidant activity strain characterized by morphological, physiological, biochemical and molecular characterization...
December 2013: Journal of Young Pharmacists: JYP
Manjunath Ajanal, Shradda Nayak, Buduru Sreenivasa Prasad, Avinash Kadam
Drug safety is a very basic and fundamental concept in medical practice. ADRs play an important role in assessing patient safety in any system of medicine. Pharmacovigilance study is thus significant to understand treatment outcomes. Current raised issue with respect to complementary and alternative system medicine (CAM) like Ayurveda is increased in number of safety reports along with report misinterpretation; this generates the negative impact on system. Although, Ayurveda which is holistic system of medicine from India has elaborated the causes and methods of drug-induced consequences along with preventive measures the available data in classical texts is scattered...
December 2013: Journal of Young Pharmacists: JYP
Mageshwaran Lakshmanan, Alphienes Stanley Xavier
Increasing incidence of MDR-TB, long duration of treatment and co-infection with HIV are the significant problems in achieving the eradication of tuberculosis. Bedaquiline is an anti-tuberculosis drug with unique mechanism of action. It selectively inhibits the mycobacterial energy metabolism i.e. ATP synthesis and found to be effective against all states of Mycobacterium tuberculosis like active, dormant, replicating, non-replicating, intracellular and extracellular. Preclinical studies have shown the efficacy of bedaquiline in terms of reduction in bacterial load and treatment duration...
December 2013: Journal of Young Pharmacists: JYP
Dubashi Biswajit
No abstract text is available yet for this article.
December 2013: Journal of Young Pharmacists: JYP
Saibal Das, Indranil Saha, Somnath Mondal, Sanjib Bandyopadhyay
No abstract text is available yet for this article.
September 2013: Journal of Young Pharmacists: JYP
Saibal Das, Somnath Mondal, Ankur Datta, Sanjib Bandyopadhyay
This report highlights an extremely rare case of dicyclomine abuse for 1.5 years by an 18-year old female resulting in overt features of anticholinergic toxicity. Strict abstinence and rehabilitation measures were employed to revert back the altered physiological state.
September 2013: Journal of Young Pharmacists: JYP
Raimundo Gonçalves de Oliveira, Grasielly Rocha Souza, Amanda Leite Guimarães, Ana Paula de Oliveira, Amanda Caroline Silva Morais, Edigênia Cavalcante da Cruz Araújo, Xirley Pereira Nunes, Jackson Roberto Guedes da Silva Almeida
The antioxidant and photoprotective activities of dried extracts from the leaves of Encholirium spectabile were investigated. It was also evaluated the total phenolic and flavonoid contents by the Folin-Ciocalteu and aluminum chloride methods, respectively. Antioxidant activities of the extracts were evaluated by using of 2,2-diphenyl-1-picrylhydrazil (DPPH) radical scavenging and β-carotene-linoleic acid bleaching and compared with ascorbic acid, butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) used as reference compounds...
September 2013: Journal of Young Pharmacists: JYP
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