Rajesh Raju, Shyam Mohan Palapetta, Varot K Sandhya, Apeksha Sahu, Abbas Alipoor, Lavanya Balakrishnan, Jayshree Advani, Bijesh George, K Ramachandra Kini, N P Geetha, H S Prakash, T S Keshava Prasad, Yu-Jung Chang, Linyi Chen, Akhilesh Pandey, Harsha Gowda
Fibroblast growth factor-1 (FGF-1) is a well characterized growth factor among the 22 members of the FGF superfamily in humans. It binds to all the four known FGF receptors and regulates a plethora of functions including cell growth, proliferation, migration, differentiation, and survival in different cell types. FGF-1 is involved in the regulation of diverse physiological processes such as development, angiogenesis, wound healing, adipogenesis, and neurogenesis. Deregulation of FGF-1 signaling is not only implicated in tumorigenesis but also is associated with tumor invasion and metastasis...
2014: Journal of Signal Transduction