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Journal of Thyroid Research

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https://www.readbyqxmd.com/read/29686830/cytomorphological-spectrum-of-thyroiditis-a-review-of-110-cases
#1
Shirish S Chandanwale, Rahul Nair, Anushree Gambhir, Supreet Kaur, Aditi Pandey, Abhinav Shetty, Piyusha Naragude
Introduction: Different types of thyroiditis may share some parallel clinical and biochemical features. Timely intervention can significantly reduce morbidity and mortality. Aim: Aim of this study is to find the frequency of various thyroiditis, study the cytomorphological features and correlate with clinical findings including radiological findings, thyroid function test, and anti-thyroid peroxidase antibodies (Anti-TPO antibodies). Materials and Methods: The study included consecutive 110 cases of thyroiditis...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29682275/follicular-thyroid-carcinoma-in-a-country-of-endemic-iodine-deficiency-1994-2013
#2
Edmund Muonir Der
Background: Follicular thyroid cancer (FTC) has historically been linked to iodine deficiency. Although Ghana is among the iodine deficient regions of the world, the proportions, trends, and the clinical features of FTCs have not been studied as a single disease entity. The aim of this study was to determine the relative frequencies, trends, and the clinicopathological characteristics of FTCs among all thyroid malignancies in our institution. Materials and Methods: This was a retrospective study from January 1994 to December 2013...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29682274/displacement-of-the-recurrent-laryngeal-nerve-in-patients-with-recurrent-goiter-undergoing-redo-thyroid-surgery
#3
Emin Gurleyik, Fuat Cetin, Sami Dogan, Erman Yekenkurul, Ufuk Onsal, Fatih Gursoy, Alper Ipor
Thyroid reoperations are surgically challenging because of scarring and disturbances in the anatomy of the recurrent laryngeal nerve (RLN). This study was conducted on 49 patients who underwent redo surgery. 61 RLNs were identified and completely exposed. Their functional integrity was evaluated using intraoperative nerve monitoring (IONM). Indications for secondary surgery, anatomical changes secondary to recurrent goiter mass and prior surgery, and results of IONM were studied. Frequent indications for redo surgery were multinodular goiter (MNG) in 19 (38...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29479488/does-the-polymorphism-in-the-length-of-the-polyalanine-tract-of-foxe1-gene-influence-the-risk-of-thyroid-dysgenesis-occurrence
#4
Clebson Pantoja Pimentel, Erik Artur Cortinhas-Alves, Edivaldo Herculano Correa de Oliveira, Luiz Carlos Santana-da-Silva
Background. Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) of FOXE1 gene may act as a susceptibility factor for thyroid dysgenesis. The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis. Method. A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease. Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29379659/thyrotoxic-atrial-fibrillation-factors-associated-with-persistence-and-risk-of-ischemic-stroke
#5
Cheuk-Lik Wong, Ho-Kee Vicki Tam, Chun-Kit Vincent Fok, Pong-Kai Ellen Lam, Lai-Ming Fung
Background: Atrial fibrillation (AF) is one of the commonest cardiovascular manifestations of thyrotoxicosis. A significant proportion of patients have persistent AF which may have long term consequences, for example, ischemic stroke. Methods: We performed a retrospective cohort study in a regional hospital from January 2004 to June 2016 to examine the clinical characteristics and outcomes of thyrotoxic patients who presented with atrial fibrillation and to investigate possible factors associated with persistent atrial fibrillation and ischemic stoke...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29209552/corrigendum-to-challenges-in-interpretation-of-thyroid-function-tests-in-pregnant-women-with-autoimmune-thyroid-disease
#6
Ulla Feldt-Rasmussen, Sofie Bliddal, Åse Krogh Rasmussen, Malene Boas, Linda Hilsted, Katharina Main
[This corrects the article DOI: 10.4061/2011/598712.].
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29201490/-18-f-fdg-pet-guided-external-beam-radiotherapy-in-iodine-refractory-differentiated-thyroid-cancer-a-pilot-study
#7
Eleonora Farina, Fabio Monari, Paolo Castellucci, Fabrizio Romani, Andrea Repaci, Arianna Farina, Giuseppe Zanirato Rambaldi, Giovanni Frezza, Renzo Mazzarotto, Silvia Cammelli, Luca Tagliaferri, Rosa Autorino, Francesco Deodato, Gabriella Macchia, Savino Cilla, Vincenzo Valentini, Stefano Fanti, Alessio G Morganti
Introduction: To evaluate the clinical response rate after a postoperative18 F-FDG PET/CT guided external beam radiotherapy (EBRT) in Iodine-refractory differentiated thyroid cancer. Material and Methods: Patients with thyroid cancer locally recurrent after total thyroidectomy plus metabolic radiotherapy and treated with radical EBRT were included. Inclusion criteria were detectable thyroglobulin (Tg), negative postmetabolic radiotherapy whole body scintigraphy, and no surgical indications...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29062583/the-end-diastolic-velocity-of-thyroid-arteries-is-strongly-correlated-with-the-peak-systolic-velocity-and-gland-volume-in-patients-with-autoimmune-thyroiditis
#8
Danilo Bianchini Höfling, Suemi Marui, Carlos Alberto Buchpiguel, Giovanni Guido Cerri, Maria Cristina Chammas
BACKGROUND: The end-diastolic velocity (EDV) of thyroid arteries reflects peripheral blood flow resistance. OBJECTIVE: The aim was to evaluate EDV correlations with other Doppler sonography parameters and with clinical and biochemical variables in a sample of patients with hypothyroidism caused by chronic autoimmune thyroiditis (CAT). METHODS: A sample of 48 CAT hypothyroid patients receiving treatment with stable doses of levothyroxine was selected...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28913004/hypermetabolic-thyroid-incidentaloma-on-positron-emission-tomography-review-of-laboratory-radiologic-and-pathologic-characteristics
#9
Mehrdad Bakhshayesh Karam, Abtin Doroudinia, Farzaneh Joukar, Kobra Nadi, Atosa Dorudinia, Payam Mehrian, Abbas Yousefikoma
INTRODUCTION: Incidental hypermetabolic thyroid lesions on Positron Emission Tomography have significant clinical value and may harbor malignancy. In this study we evaluated laboratory, radiologic, and pathologic characteristics of incidental hypermetabolic thyroid lesions. MATERIALS AND METHODS: We evaluated 18 patients prospectively with various malignancies and hypermetabolic thyroid incidentaloma. The thyroid function tests, ultrasound assessment, and guided FNA biopsy were performed on all cases...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28913003/corrigendum-to-the-relationship-between-population-t4-tsh-set-point-data-and-t4-tsh-physiology
#10
Stephen Paul Fitzgerald, Nigel Geoffrey Bean
[This corrects the article DOI: 10.1155/2016/6351473.].
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28894619/immunological-reactivity-using-monoclonal-and-polyclonal-antibodies-of-autoimmune-thyroid-target-sites-with-dietary-proteins
#11
Datis Kharrazian, Martha Herbert, Aristo Vojdani
Many hypothyroid and autoimmune thyroid patients experience reactions with specific foods. Additionally, food interactions may play a role in a subset of individuals who have difficulty finding a suitable thyroid hormone dosage. Our study was designed to investigate the potential role of dietary protein immune reactivity with thyroid hormones and thyroid axis target sites. We identified immune reactivity between dietary proteins and target sites on the thyroid axis that includes thyroid hormones, thyroid receptors, enzymes, and transport proteins...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28630779/impact-of-obesity-on-serum-levels-of-thyroid-hormones-among-euthyroid-saudi-adults
#12
Hassan M Al-Musa
AIM OF STUDY: To assess serum thyroid hormones levels among Saudi adults and to correlate participants' serum levels with their grades of body mass index (BMI). METHODOLOGY: A total of 278 adult subjects were recruited. Participants were categorized according to their BMI grades into normal weight (BMI < 25 kg/m(2)), overweight (BMI 25-29.9 kg/m(2)), or obese (BMI ≥ 30 kg/m(2)). Serum thyroid hormones levels were assessed at the central laboratory of Aseer Central Hospital, Abha City, by chemiluminescence immunoassay...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28286688/beneficial-effects-on-pregnancy-outcomes-of-thyroid-hormone-replacement-for-subclinical-hypothyroidism
#13
Norman J Blumenthal, Creswell J Eastman
Background. Hypothyroidism and raised thyroid antibody levels have been associated with adverse obstetrical outcomes. Several studies have investigated causal associations, but results have been inconsistent and few studies have reported the effects of thyroxine replacement therapy on pregnancy outcomes in hypothyroid patients. Objective. The primary study objective was to determine the outcome of pregnancies in women diagnosed with overt and subclinical hypothyroidism (SCH) (serum TSH > 2.5 mIU/L) and those with elevated circulating thyroid autoantibody levels in the first trimester of pregnancy and after the institution of appropriate thyroxine replacement therapy to maintain the serum TSH ≤ 2...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28025634/regional-variation-across-canadian-centers-in-radioiodine-administration-for-thyroid-remnant-ablation-in-well-differentiated-thyroid-cancer-diagnosed-in-2000-2010
#14
I Rachinsky, M Rajaraman, W D Leslie, A Zahedi, C Jefford, A McGibbon, J E M Young, K A Pathak, M Badreddine, S De Brabandere, H Fong, S Van Uum
Background. Use of radioactive iodine (RAI) ablation has been reported to vary significantly between studies. We explored variation in RAI ablation care patterns between seven thyroid cancer treatment centers in Canada. Methods. The Canadian Collaborative Network for Cancer of the Thyroid (CANNECT) is a collaborative registry to describe and analyze patterns of care for thyroid cancer. We analyzed data from seven participating centers on RAI ablation in patients diagnosed with well-differentiated (papillary and follicular) thyroid cancer between 2000 and 2010...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27648339/morphological-diversity-of-pretibial-myxedema-and-its-mechanism-of-evolving-process-and-outcome-a-retrospective-study-of-216-cases
#15
Changgui Lan, Yi Wang, Xia Zeng, Jing Zhao, Xiaoxi Zou
Background. Pretibial myxedema (PTM) is a rare dermopathy. The morphologic features and mechanism of its evolving process are not reported in large case series. Methods. 216 cases with PTM were retrospectively reviewed to analyze demographics, history, lesional morphology and its evolving process, histopathology and immunohistochemistry, serum TRAb levels, treatment, and outcome. Results. First appearing lesions evolved into 6 variants that were correlated with serum TRAb levels. Subvariants were caused by different kinds and frequencies of local trauma...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27433368/corrigendum-to-how-to-treat-a-signal-current-basis-for-ret-genotype-oriented-choice-of-kinase-inhibitors-for-the-treatment-of-medullary-thyroid-cancer
#16
Hugo Prazeres, Joana Torres, Fernando Rodrigues, Joana P Couto, João Vinagre, Manuel Sobrinho-Simões, Paula Soares
[This corrects the article DOI: 10.4061/2011/678357.].
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27403370/predictors-of-regional-lymph-node-recurrence-after-initial-thyroidectomy-in-patients-with-thyroid-cancer
#17
Amirsina Sharifi, Abolfazl Shojaeifard, Ahmadreza Soroush, Mehdi Jafari, Ali Ghorbani Abdehgah, Hossein Mahmoudzade
Background. Regional lymph node recurrence (RLNR) is common in patients with thyroid cancer but clinicopathological predictors are unclear. We aimed to clarify these predictors and identify patients who would benefit from prophylactic lymph node dissection the most. Method. 343 patients with different types of thyroid cancer were analyzed retrospectively. All patients underwent total thyroidectomy between 2007 and 2013. Results. The median ± interquartile range of patients' age was 40 ± 25 years. 245 (71...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27379194/frtl-5-rat-thyroid-cells-release-thyroglobulin-sequestered-in-exosomes-a-possible-novel-mechanism-for-thyroglobulin-processing-in-the-thyroid
#18
Pavel Vlasov, Sonia Q Doi, Donald F Sellitti
Exosomes are 30-100 nm, membrane-bound vesicles containing specific cellular proteins, mRNAs, and microRNAs that take part in intercellular communication between cells. A possible role for exosomes in thyroid function has not been fully explored. In the present study, FRTL-5 rat thyroid cells were grown to confluence and received medium containing either thyroid stimulating hormone (TSH), exogenous bovine thyroglobulin (bTg), or neither additive for 24 or 48 hours followed by collection of spent medium and ultracentrifugation to isolate small vesicles...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27313946/change-in-practice-over-four-decades-in-the-management-of-graves-disease-in-scotland
#19
D M Smith, S Dutta, F Ahmed, M A Thaha
There is continuing debate on the optimal treatment for Grave's thyrotoxicosis with a resultant variation in clinical practice. The present study aimed to ascertain changes in practice in the treatment of Grave's thyrotoxicosis in Tayside, Scotland, over the past four decades. Methods. The "Scottish automated follow-up register" (SAFUR) was queried to identify all patients treated for Grave's thyrotoxicosis from 1968 to 2007 inclusive. Patients were divided into 4 groups (Groups A to D) according to the decades...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27213079/association-between-tumor-size-and-bilateral-involvement-in-papillary-thyroid-carcinoma
#20
Suna Erkilic, Fatih Celenk, Zehra Bozdag
Background. Tumor multifocality and bilaterality of papillary thyroid carcinoma (PTC) are important factors when selecting the most appropriate surgical procedure. The aim of this study was to assess the bilaterality rate in PTC and the relationship between the tumor size and bilaterality. Materials and Methods. Thyroidectomy specimens with a diagnosis of PTC were retrospectively reviewed in the Pathology Department of a tertiary care medical center. Specimens were divided into three groups according to the size of the primary and contralateral tumor foci...
2016: Journal of Thyroid Research
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