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Journal of Thyroid Research

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https://www.readbyqxmd.com/read/30174822/prevalence-and-associations-of-hypothyroidism-in-indian-patients-with-type-2-diabetes-mellitus
#1
Abilash Nair, C Jayakumari, P K Jabbar, R V Jayakumar, Nishant Raizada, Anjana Gopi, Geena Susan George, T P Seena
Both type 2 diabetes and hypothyroidism are highly prevalent disorders in the community. The existing data regarding prevalence of hypothyroidism in patients with diabetes comes mostly from small studies. There are only two studies with a sample size of more than 1000 diabetic patients, none of which have been done in South Asians. The present study evaluated patients with type 2 diabetes for presence of hypothyroidism and the clinical factors associated with it. The demographic, anthropometric, clinical, and biochemical parameters of consecutively enrolled patients with diabetes were systematically collected and analyzed...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/30174821/lessons-from-randomised-clinical-trials-for-triiodothyronine-treatment-of-hypothyroidism-have-they-achieved-their-objectives
#2
Rudolf Hoermann, John E M Midgley, Rolf Larisch, Johannes W Dietrich
Randomised controlled trials are deemed to be the strongest class of evidence in evidence-based medicine. Failure of trials to prove superiority of T3/T4 combination therapy over standard LT4 monotherapy has greatly influenced guidelines, while not resolving the ongoing debate. Novel studies have recently produced more evidence from the examination of homeostatic equilibria in humans and experimental treatment protocols in animals. This has exacerbated a serious disagreement with evidence from the clinical trials...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/30155237/short-stay-thyroid-surgery-can-we-replicate-the-same-in-low-resource-setting
#3
Naval Bansal, Sanjay Kumar Yadav, Saroj Kanta Mishra, Kamal Kishore, Anjali Mishra, Gyan Chand, Gaurav Agarwal, Amit Agarwal, Ashok Kumar Verma
Introduction: The concept of short stay thyroidectomy has been tested and in practice in the developed world; the same has not been replicated in countries with limited resources due to lack of organized healthcare system. So, in this study, we tried to analyze if short stay thyroid surgery can be performed in a cost-effective way in developing countries and also if the endocrine surgical trainee can deliver these services safely. Methods: The study was conducted prospectively from January 2013 to July 2014, at Department of Endocrine Surgery, SGPGIMS, Lucknow, India...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/30151097/metabolic-syndrome-and-subclinical-hypothyroidism-a-type-2-diabetes-dependent-association
#4
Valmore Bermúdez, Juan Salazar, Roberto Añez, Milagros Rojas, Viviana Estrella, María Ordoñez, Maricarmen Chacín, Juan Diego Hernández, Víctor Arias, Mayela Cabrera, Clímaco Cano-Ponce, Joselyn Rojas
Introduction: Subclinical hypothyroidism (ScH) is an endocrine alteration that is related to cardiovascular risk factors, including those categorized as components of the Metabolic Syndrome (MS). However, findings in prior reports regarding an association between these alterations are inconsistent. The purpose of this study was to determine the relationship between both entities in adult subjects from Maracaibo City, Venezuela. Materials and Methods: The Maracaibo City Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study with random and multistage sampling...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/30046434/incidence-of-second-malignancy-in-patients-with-papillary-thyroid-cancer-from-surveillance-epidemiology-and-end-results-13-dataset
#5
Mayumi Endo, Jessica B Liu, Marcelle Dougan, Jennifer S Lee
Increased risk of second primary malignancy (SPM) in papillary thyroid cancer (PTC) has been reported. Here, we present the most updated incidence rates of second primary malignancy from original diagnosis of PTC by using the data from the Surveillance, Epidemiology, and End Results. In this cohort, 3,200 patients developed SPM, a substantially higher number than in the reference population of 2,749 with observed to expected ratio (O/E) of 1.16 (95% CI; 1.12-1.21). Bone and joint cancer had the highest O/E ratio of 4...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29862009/spontaneous-slowing-and-regressing-of-tumor-growth-in-childhood-adolescent-papillary-thyroid-carcinomas-suggested-by-the-postoperative-thyroglobulin-doubling-time
#6
Toshihiko Kasahara, Akira Miyauchi, Takumi Kudo, Eijun Nishihara, Mitsuru Ito, Yasuhiro Ito, Minoru Kihara, Akihiro Miya
Background: Children and adolescents with papillary thyroid carcinomas (PTCs) have generally excellent prognoses despite their frequent extended disease. The tumor growth of young patients' PTCs might show spontaneous slowing postoperatively. We compared young PTC patients' postoperative thyroglobulin-doubling time (Tg-DT) with their preoperative hypothetical tumor volume-doubling time (hTV-DT). Methods: Fourteen PTC patients aged ≤18 years who underwent total thyroidectomy at Kuma Hospital in 1998-2016 had biochemically persistent disease postoperatively...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29854383/the-outcome-of-papillary-thyroid-cancer-associated-with-graves-disease-a-case-control-study
#7
Riju Menon, C Gopalakrishnan Nair, Misha Babu, Pradeep Jacob, G Praveen Krishna
Introduction: Thyroidectomy is now a less popular therapeutic option for Graves' disease. The frequency of thyroid nodule and the cancer risk of these nodules accompanying Graves' disease are controversial. The outcome of thyroid cancers coexisting with Graves' disease is debated. Study Design: Designed as retrospective case control study of papillary thyroid cancers associated with Graves' disease and those with euthyroid background. Pathological characteristics and outcome of papillary thyroid cancers in the two groups were compared...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29850012/significance-of-testing-anti-thyroid-autoantibodies-in-patients-with-deranged-thyroid-profile
#8
Hamid Nawaz Tipu, Dawood Ahmed, Muhammad Mukarram Bashir, Naveed Asif
Background: We hypothesized that anti-thyroid antibodies are more often positive in individuals with deranged thyroid profile. Methods: This prospective cohort was done in Immunology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan, from Jan 2017 to Oct 2017. All the samples that were referred to us for testing anti-thyroid antibodies (anti-TPO or anti-TG antibodies) and thyroid profile were included in the study. There were no exclusion criteria...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29850011/diagnostic-accuracy-of-preoperative-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios-in-detecting-occult-papillary-thyroid-microcarcinomas-in-benign-multinodular-goitres
#9
Dimitrios K Manatakis, Sophia Tseleni-Balafouta, Lazaros Tzelves, Dimitrios Balalis, Adelais Tzortzopoulou, Dimitrios P Korkolis, George H Sakorafas, Emmanouil Gontikakis, Georgios Plataniotis
Objective: To investigate the diagnostic accuracy of neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios in detecting occult papillary thyroid microcarcinomas in benign, multinodular goitres. Methods: 397 total thyroidectomy patients were identified from the institutional thyroid surgery database between 2007 and 2016 (94 males, 303 females, mean age 53 ± 14.5 years). NLR and PLR were calculated as the absolute neutrophil and absolute platelet counts divided by the absolute lymphocyte count, respectively, based on the preoperative complete blood cell count...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29686830/cytomorphological-spectrum-of-thyroiditis-a-review-of-110-cases
#10
Shirish S Chandanwale, Rahul Nair, Anushree Gambhir, Supreet Kaur, Aditi Pandey, Abhinav Shetty, Piyusha Naragude
Introduction: Different types of thyroiditis may share some parallel clinical and biochemical features. Timely intervention can significantly reduce morbidity and mortality. Aim: Aim of this study is to find the frequency of various thyroiditis, study the cytomorphological features and correlate with clinical findings including radiological findings, thyroid function test, and anti-thyroid peroxidase antibodies (Anti-TPO antibodies). Materials and Methods: The study included consecutive 110 cases of thyroiditis...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29682275/follicular-thyroid-carcinoma-in-a-country-of-endemic-iodine-deficiency-1994-2013
#11
Edmund Muonir Der
Background: Follicular thyroid cancer (FTC) has historically been linked to iodine deficiency. Although Ghana is among the iodine deficient regions of the world, the proportions, trends, and the clinical features of FTCs have not been studied as a single disease entity. The aim of this study was to determine the relative frequencies, trends, and the clinicopathological characteristics of FTCs among all thyroid malignancies in our institution. Materials and Methods: This was a retrospective study from January 1994 to December 2013...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29682274/displacement-of-the-recurrent-laryngeal-nerve-in-patients-with-recurrent-goiter-undergoing-redo-thyroid-surgery
#12
Emin Gurleyik, Fuat Cetin, Sami Dogan, Erman Yekenkurul, Ufuk Onsal, Fatih Gursoy, Alper Ipor
Thyroid reoperations are surgically challenging because of scarring and disturbances in the anatomy of the recurrent laryngeal nerve (RLN). This study was conducted on 49 patients who underwent redo surgery. 61 RLNs were identified and completely exposed. Their functional integrity was evaluated using intraoperative nerve monitoring (IONM). Indications for secondary surgery, anatomical changes secondary to recurrent goiter mass and prior surgery, and results of IONM were studied. Frequent indications for redo surgery were multinodular goiter (MNG) in 19 (38...
2018: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29479488/does-the-polymorphism-in-the-length-of-the-polyalanine-tract-of-foxe1-gene-influence-the-risk-of-thyroid-dysgenesis-occurrence
#13
Clebson Pantoja Pimentel, Erik Artur Cortinhas-Alves, Edivaldo Herculano Correa de Oliveira, Luiz Carlos Santana-da-Silva
Background. Recent data have suggested that polymorphisms in the length of the polyalanine tract (polyA) of FOXE1 gene may act as a susceptibility factor for thyroid dysgenesis. The main purpose of this study was to investigate the influence of polyA of FOXE1 gene on the risk of thyroid dysgenesis. Method. A case-control study was conducted in a sample of 90 Brazilian patients with thyroid dysgenesis and 131 controls without family history of thyroid disease. Genomic DNA was isolated from peripheral blood samples and the genotype of each individual was determined by automated sequencing...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29379659/thyrotoxic-atrial-fibrillation-factors-associated-with-persistence-and-risk-of-ischemic-stroke
#14
Cheuk-Lik Wong, Ho-Kee Vicki Tam, Chun-Kit Vincent Fok, Pong-Kai Ellen Lam, Lai-Ming Fung
Background: Atrial fibrillation (AF) is one of the commonest cardiovascular manifestations of thyrotoxicosis. A significant proportion of patients have persistent AF which may have long term consequences, for example, ischemic stroke. Methods: We performed a retrospective cohort study in a regional hospital from January 2004 to June 2016 to examine the clinical characteristics and outcomes of thyrotoxic patients who presented with atrial fibrillation and to investigate possible factors associated with persistent atrial fibrillation and ischemic stoke...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29209552/corrigendum-to-challenges-in-interpretation-of-thyroid-function-tests-in-pregnant-women-with-autoimmune-thyroid-disease
#15
Ulla Feldt-Rasmussen, Sofie Bliddal, Åse Krogh Rasmussen, Malene Boas, Linda Hilsted, Katharina Main
[This corrects the article DOI: 10.4061/2011/598712.].
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29201490/-18-f-fdg-pet-guided-external-beam-radiotherapy-in-iodine-refractory-differentiated-thyroid-cancer-a-pilot-study
#16
Eleonora Farina, Fabio Monari, Paolo Castellucci, Fabrizio Romani, Andrea Repaci, Arianna Farina, Giuseppe Zanirato Rambaldi, Giovanni Frezza, Renzo Mazzarotto, Silvia Cammelli, Luca Tagliaferri, Rosa Autorino, Francesco Deodato, Gabriella Macchia, Savino Cilla, Vincenzo Valentini, Stefano Fanti, Alessio G Morganti
Introduction: To evaluate the clinical response rate after a postoperative18 F-FDG PET/CT guided external beam radiotherapy (EBRT) in Iodine-refractory differentiated thyroid cancer. Material and Methods: Patients with thyroid cancer locally recurrent after total thyroidectomy plus metabolic radiotherapy and treated with radical EBRT were included. Inclusion criteria were detectable thyroglobulin (Tg), negative postmetabolic radiotherapy whole body scintigraphy, and no surgical indications...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/29062583/the-end-diastolic-velocity-of-thyroid-arteries-is-strongly-correlated-with-the-peak-systolic-velocity-and-gland-volume-in-patients-with-autoimmune-thyroiditis
#17
Danilo Bianchini Höfling, Suemi Marui, Carlos Alberto Buchpiguel, Giovanni Guido Cerri, Maria Cristina Chammas
BACKGROUND: The end-diastolic velocity (EDV) of thyroid arteries reflects peripheral blood flow resistance. OBJECTIVE: The aim was to evaluate EDV correlations with other Doppler sonography parameters and with clinical and biochemical variables in a sample of patients with hypothyroidism caused by chronic autoimmune thyroiditis (CAT). METHODS: A sample of 48 CAT hypothyroid patients receiving treatment with stable doses of levothyroxine was selected...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28913004/hypermetabolic-thyroid-incidentaloma-on-positron-emission-tomography-review-of-laboratory-radiologic-and-pathologic-characteristics
#18
Mehrdad Bakhshayesh Karam, Abtin Doroudinia, Farzaneh Joukar, Kobra Nadi, Atosa Dorudinia, Payam Mehrian, Abbas Yousefikoma
INTRODUCTION: Incidental hypermetabolic thyroid lesions on Positron Emission Tomography have significant clinical value and may harbor malignancy. In this study we evaluated laboratory, radiologic, and pathologic characteristics of incidental hypermetabolic thyroid lesions. MATERIALS AND METHODS: We evaluated 18 patients prospectively with various malignancies and hypermetabolic thyroid incidentaloma. The thyroid function tests, ultrasound assessment, and guided FNA biopsy were performed on all cases...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28913003/corrigendum-to-the-relationship-between-population-t4-tsh-set-point-data-and-t4-tsh-physiology
#19
Stephen Paul Fitzgerald, Nigel Geoffrey Bean
[This corrects the article DOI: 10.1155/2016/6351473.].
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28894619/immunological-reactivity-using-monoclonal-and-polyclonal-antibodies-of-autoimmune-thyroid-target-sites-with-dietary-proteins
#20
Datis Kharrazian, Martha Herbert, Aristo Vojdani
Many hypothyroid and autoimmune thyroid patients experience reactions with specific foods. Additionally, food interactions may play a role in a subset of individuals who have difficulty finding a suitable thyroid hormone dosage. Our study was designed to investigate the potential role of dietary protein immune reactivity with thyroid hormones and thyroid axis target sites. We identified immune reactivity between dietary proteins and target sites on the thyroid axis that includes thyroid hormones, thyroid receptors, enzymes, and transport proteins...
2017: Journal of Thyroid Research
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