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Journal of Thyroid Research

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https://www.readbyqxmd.com/read/27648339/morphological-diversity-of-pretibial-myxedema-and-its-mechanism-of-evolving-process-and-outcome-a-retrospective-study-of-216-cases
#1
Changgui Lan, Yi Wang, Xia Zeng, Jing Zhao, Xiaoxi Zou
Background. Pretibial myxedema (PTM) is a rare dermopathy. The morphologic features and mechanism of its evolving process are not reported in large case series. Methods. 216 cases with PTM were retrospectively reviewed to analyze demographics, history, lesional morphology and its evolving process, histopathology and immunohistochemistry, serum TRAb levels, treatment, and outcome. Results. First appearing lesions evolved into 6 variants that were correlated with serum TRAb levels. Subvariants were caused by different kinds and frequencies of local trauma...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27433368/corrigendum-to-how-to-treat-a-signal-current-basis-for-ret-genotype-oriented-choice-of-kinase-inhibitors-for-the-treatment-of-medullary-thyroid-cancer
#2
Hugo Prazeres, Joana Torres, Fernando Rodrigues, Joana P Couto, João Vinagre, Manuel Sobrinho-Simões, Paula Soares
[This corrects the article DOI: 10.4061/2011/678357.].
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27403370/predictors-of-regional-lymph-node-recurrence-after-initial-thyroidectomy-in-patients-with-thyroid-cancer
#3
Amirsina Sharifi, Abolfazl Shojaeifard, Ahmadreza Soroush, Mehdi Jafari, Ali Ghorbani Abdehgah, Hossein Mahmoudzade
Background. Regional lymph node recurrence (RLNR) is common in patients with thyroid cancer but clinicopathological predictors are unclear. We aimed to clarify these predictors and identify patients who would benefit from prophylactic lymph node dissection the most. Method. 343 patients with different types of thyroid cancer were analyzed retrospectively. All patients underwent total thyroidectomy between 2007 and 2013. Results. The median ± interquartile range of patients' age was 40 ± 25 years. 245 (71...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27379194/frtl-5-rat-thyroid-cells-release-thyroglobulin-sequestered-in-exosomes-a-possible-novel-mechanism-for-thyroglobulin-processing-in-the-thyroid
#4
Pavel Vlasov, Sonia Q Doi, Donald F Sellitti
Exosomes are 30-100 nm, membrane-bound vesicles containing specific cellular proteins, mRNAs, and microRNAs that take part in intercellular communication between cells. A possible role for exosomes in thyroid function has not been fully explored. In the present study, FRTL-5 rat thyroid cells were grown to confluence and received medium containing either thyroid stimulating hormone (TSH), exogenous bovine thyroglobulin (bTg), or neither additive for 24 or 48 hours followed by collection of spent medium and ultracentrifugation to isolate small vesicles...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27313946/change-in-practice-over-four-decades-in-the-management-of-graves-disease-in-scotland
#5
D M Smith, S Dutta, F Ahmed, M A Thaha
There is continuing debate on the optimal treatment for Grave's thyrotoxicosis with a resultant variation in clinical practice. The present study aimed to ascertain changes in practice in the treatment of Grave's thyrotoxicosis in Tayside, Scotland, over the past four decades. Methods. The "Scottish automated follow-up register" (SAFUR) was queried to identify all patients treated for Grave's thyrotoxicosis from 1968 to 2007 inclusive. Patients were divided into 4 groups (Groups A to D) according to the decades...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27213079/association-between-tumor-size-and-bilateral-involvement-in-papillary-thyroid-carcinoma
#6
Suna Erkilic, Fatih Celenk, Zehra Bozdag
Background. Tumor multifocality and bilaterality of papillary thyroid carcinoma (PTC) are important factors when selecting the most appropriate surgical procedure. The aim of this study was to assess the bilaterality rate in PTC and the relationship between the tumor size and bilaterality. Materials and Methods. Thyroidectomy specimens with a diagnosis of PTC were retrospectively reviewed in the Pathology Department of a tertiary care medical center. Specimens were divided into three groups according to the size of the primary and contralateral tumor foci...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27123359/the-relationship-between-population-t4-tsh-set-point-data-and-t4-tsh-physiology
#7
Stephen Paul Fitzgerald, Nigel Geoffrey Bean
Context. Population studies of the distribution of T4/TSH set points suggest a more complex inverse relationship between T4 and TSH than that suggested by physiological studies. The reasons for the similarities and differences between the curves describing these relationships are unresolved. Methods. We subjected the curve, derived from empiric data, describing the TSH suppression response to T4, and the more mathematically derived curve describing the T4 response to TSH, to the different possible models of population variation...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27123358/hypothyroidism-in-pancreatic-cancer-role-of-exogenous-thyroid-hormone-in-tumor-invasion-preliminary-observations
#8
Konrad Sarosiek, Ankit V Gandhi, Shivam Saxena, Christopher Y Kang, Galina I Chipitsyna, Charles J Yeo, Hwyda A Arafat
According to the epidemiological studies, about 4.4% of American general elderly population has a pronounced hypothyroidism and relies on thyroid hormone supplements daily. The prevalence of hypothyroidism in our patients with pancreatic cancer was much higher, 14.1%. A retrospective analysis was performed on patients who underwent pancreaticoduodenectomy (Whipple procedure) or distal pancreatectomy and splenectomy (DPS) at Thomas Jefferson University Hospital, Philadelphia, from 2005 to 2012. The diagnosis of hypothyroidism was correlated with clinicopathologic parameters including tumor stage, grade, and survival...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27057371/quercetin-induced-cell-death-in-human-papillary-thyroid-cancer-b-cpap-cells
#9
Ergül Mutlu Altundağ, Tolga Kasacı, Ayşe Mine Yılmaz, Betül Karademir, Semra Koçtürk, Yavuz Taga, A Süha Yalçın
In this study, we have investigated the antiproliferative effect of quercetin on human papillary thyroid cancer cells and determined the apoptotic mechanisms underlying its actions. We have used different concentrations of quercetin to induce apoptosis and measured cell viability. Apoptosis and cell cycle analysis was determined by flow cytometry using Annexin V and propidium iodide. Finally, we have measured changes in caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP) protein expression levels as hallmarks of apoptosis and Hsp90 protein expression level as a marker of proteasome activity in treated and control cells...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27034886/effect-of-preoperative-nerve-block-on-postthyroidectomy-headache-and-cervical-pain-a-randomized-prospective-study
#10
Sunil Malla Bujar Barua, Anjali Mishra, Kamal Kishore, Saroj Kanta Mishra, Gyan Chand, Gaurav Agarwal, Amit Agarwal, Ashok Kumar Verma
The aim of the current study was to investigate the efficacy of greater occipital nerve (GON) block and bilateral superficial cervical plexuses (BSCP) blocks in alleviating postoperative occipital headache and posterior neck pain after thyroidectomy. This randomized prospective study consisted of 75 women undergoing total thyroidectomy. Patients were randomized into three groups: Group I (n = 25): patients receiving GON, Group II (n = 25): patients receiving bilateral (BSCP) blocks, and Group III (n = 25): patients receiving no block...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27034885/significance-of-interleukin-6-in-papillary-thyroid-carcinoma
#11
Toral P Kobawala, Trupti I Trivedi, Kinjal K Gajjar, Darshita H Patel, Girish H Patel, Nandita R Ghosh
This study sought to reveal the significance of IL-6 in papillary thyroid carcinoma by determining its circulating levels, tumoral protein, and mRNA expressions. As compared to the healthy individuals, serum IL-6 was significantly higher in patients with benign thyroid diseases and PTC. Further, its level was significantly higher in PTC patients as compared to patients with benign thyroid diseases. ROC curves also confirmed a good discriminatory efficacy of serum IL-6 between healthy individuals and patients with benign thyroid diseases and PTC...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/27006857/safety-and-effectiveness-of-total-thyroidectomy-and-its-comparison-with-subtotal-thyroidectomy-and-other-thyroid-surgeries-a-systematic-review
#12
REVIEW
Ashwini Aithal Padur, Naveen Kumar, Anitha Guru, Satheesha Nayak Badagabettu, Swamy Ravindra Shanthakumar, Murlimanju Bukkambudhi Virupakshamurthy, Jyothsna Patil
Diseases associated with the thyroid gland are one of the most frequently seen endocrine disorders across the globe. Total thyroidectomy is currently the preferred treatment for many thyroid diseases. Controversies exist among surgeons regarding safety of total thyroidectomy due to the risk associated with it like postoperative hypoparathyroidism or recurrent laryngeal nerve damage. Since, in the recent years, the incidence of thyroidectomy is in increasing trend in south Indian population, this review aims to study the available data regarding the appropriateness and safety of total thyroidectomy and compares it with subtotal thyroidectomy and other thyroid surgeries...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/26989557/prenatal-exposures-to-multiple-thyroid-hormone-disruptors-effects-on-glucose-and-lipid-metabolism
#13
REVIEW
Deborah Molehin, Marloes Dekker Nitert, Kerry Richard
Background. Thyroid hormones (THs) are essential for normal human fetal development and play a major role in the regulation of glucose and lipid metabolism. Delivery of TH to target tissues is dependent on processes including TH synthesis, transport, and metabolism. Thyroid hormone endocrine disruptors (TH-EDCs) are chemical substances that interfere with these processes, potentially leading to adverse pregnancy outcomes. Objectives. This review focuses on the effects of prenatal exposures to combinations of TH-EDCs on fetal and neonatal glucose and lipid metabolism and also discusses the various mechanisms by which TH-EDCs interfere with other hormonal pathways...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/26949559/incidental-papillary-thyroid-microcarcinoma-in-an-endemic-goiter-area
#14
Emin Gürleyik, Gunay Gurleyik, Banu Karapolat, Ufuk Onsal
Clinical and pathological characteristics of incidental papillary thyroid microcancer cases, surgical, medical, and nuclear treatment methods, and patients' outcome were studied during follow-up period of 102 months. We studied 37 patients with incidental papillary thyroid microcancer (I-PTM). The surgical procedure was total thyroidectomy in 29 and hemithyroidectomy in 8 patients. Size, multifocality, and bilateralism of PTM foci, thyroid capsule invasion, and presence of lymphovascular invasion were histopathological parameters...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/26881177/significance-of-tnf-%C3%AE-and-the-adhesion-molecules-l-selectin-and-vcam-1-in-papillary-thyroid-carcinoma
#15
Toral P Kobawala, Trupti I Trivedi, Kinjal K Gajjar, Darshita H Patel, Girish H Patel, Nandita R Ghosh
Circulating levels of TNF-α and the adhesion molecules L-Selectin and VCAM-1 as well as their expression in the primary tumors of patients with benign thyroid diseases and papillary thyroid carcinoma (PTC) have been determined in this study. The serum levels of TNF-α, L-Selectin, and VCAM-1 were significantly higher in patients with both benign thyroid diseases and PTC as compared to the healthy individuals. However, the levels of only TNF-α and L-Selectin, and not VCAM-1, were significantly higher in patients with PTC in comparison to those observed in patients with benign thyroid diseases...
2016: Journal of Thyroid Research
https://www.readbyqxmd.com/read/26798549/thyroid-autoantibodies-in-the-cerebrospinal-fluid-of-subjects-with-and-without-thyroid-disease-implications-for-hashimoto-s-encephalopathy
#16
Ioannis Ilias, Vasiliki Karagiorga, George Paraskevas, Anastasia Bougea, Mara Bourbouli, Athina Pappa, Stamatina Nikopoulou, Elisabeth Kapaki
Introduction. Plasma antithyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies (anti-Tg) are widely used in the diagnosis of autoimmune thyroiditis. No research has compared anti-TPO and anti-Tg both in plasma and cerebrospinal fluid (CSF) of healthy individuals vis-à-vis patients with thyroid disease. Methods. We measured anti-TPO and anti-Tg antibodies in plasma and CSF in nine subjects (mean age ± SD: 73 ± 6 years) with hypothyroidism and nine subjects (mean age ± SD: 73 ± 8 years) without thyroid disease...
2015: Journal of Thyroid Research
https://www.readbyqxmd.com/read/26798548/relationship-between-clinical-and-immunological-features-of-thyroid-autoimmunity-and-ophthalmopathy-during-pregnancy
#17
Jack R Wall, Hooshang Lahooti, Emily J Hibbert, Bernard Champion
Problem. Clinical features of Graves' hyperthyroidism (GH) generally improve during pregnancy and rebound in the postpartum period. It is unclear whether the ophthalmopathy that is associated with GH and, less often, Hashimoto's thyroiditis (HT) changes in parallel with the thyroid associated antibody reactions and clinical features or runs a different course. Method of Study. We retrospectively studied 19 patients with autoimmune thyroid disease over 22 pregnancies: 9 pregnancies with GH and 13 with HT. Ophthalmopathy was defined by NOSPECS class...
2015: Journal of Thyroid Research
https://www.readbyqxmd.com/read/26798547/prevalence-and-predictors-of-thyroid-dysfunction-in-patients-with-hiv-infection-and-acquired-immunodeficiency-syndrome-an-indian-perspective
#18
Neera Sharma, Lokesh Kumar Sharma, Deep Dutta, Adesh Kisanji Gadpayle, Atul Anand, Kumar Gaurav, Sabyasachi Mukherjee, Rahul Bansal
Background. Predictors of thyroid dysfunction in HIV are not well determined. This study aimed to determine the prevalence and predictors of thyroid dysfunction in HIV infected Indians. Methods. Consecutive HIV patients, 18-70 years of age, without any severe comorbid state, having at least 1-year follow-up at the antiretroviral therapy clinic, underwent clinical assessment and hormone assays. Results. From initially screened 527 patients, 359 patients (61.44 ± 39.42 months' disease duration), having good immune function [CD4 count >200 cell/mm(3): 90...
2015: Journal of Thyroid Research
https://www.readbyqxmd.com/read/26697261/patient-benefit-risk-tradeoffs-for-radioactive-iodine-refractory-differentiated-thyroid-cancer-treatments
#19
Ateesha F Mohamed, Juan Marcos González, Angelyn Fairchild
Background. The aims of this study were to assess patients' preferences to wait or start systemic treatment and understand how patients would make tradeoffs between certain severe adverse events (AEs) and additional months of progression-free survival (PFS). Materials and Methods. Adults in France, Germany, and Spain with a diagnosis of DTC and who have had at least one RAI treatment completed a direct-elicitation question and a discrete-choice experiment (DCE) online. The direct-elicitation question asked respondents whether they would opt out of treatment when their tumor is RAI-R...
2015: Journal of Thyroid Research
https://www.readbyqxmd.com/read/26523236/cardiovascular-risk-factors-in-subclinical-hypothyroidism-a-case-control-study-in-nepalese-population
#20
Rajendra Kc, Saroj Khatiwada, Kishun Deo Mehta, Pratikshya Pandey, Madhab Lamsal, Shankhar Majhi
Objectives. To assess cardiovascular risk factors in Nepalese population with subclinical hypothyroidism as compared to age and sex matched controls. Materials and Methods. A case control study was conducted among 200 subjects (100 subclinical hypothyroid and 100 euthyroid) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Demographic and anthropometric variables including systolic and diastolic blood pressure (BP) were taken. Blood samples were assayed for serum free triiodothyronine (fT3), free thyroxine (fT4), thyroid stimulating hormone (TSH), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and high sensitivity C reactive protein (hs-CRP)...
2015: Journal of Thyroid Research
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