Yan-Fei Zhang, Liu-Liu Yuan, Zong-Can Wang, Wen-Bin Zhuang, Wen-Jia Zhang, Hai-Tao Liu, Ming Li, Li-Hong Fan
Background: DHEA is a steroid hormone produced by the gonads, adrenal cortex, brain, and gastrointestinal tract. While the anti-obesity, anti-atherosclerosis, anti-cancer, and memory-enhancing effects of DHEA have been substantiated through cell experiments, animal studies, and human trials, the precise mechanisms underlying these effects remain unclear. Altered mitochondrial dynamics can lead to mitochondrial dysfunction, which is closely related to many human diseases, especially cancer and aging. This study was to investigate whether DHEA inhibits lung adenocarcinoma through the mitochondrial pathway and its molecular mechanism...
2024: Journal of Cancer