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Journal of Cancer

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https://www.readbyqxmd.com/read/29896291/impact-of-interstitial-lung-disease-classification-on-the-development-of-acute-exacerbation-of-interstitial-lung-disease-and-prognosis-in-patients-with-stage-iii-non-small-cell-lung-cancer-and-interstitial-lung-disease-treated-with-chemoradiotherapy
#1
Haruki Kobayashi, Tateaki Naito, Katsuhiro Omae, Shota Omori, Kazuhisa Nakashima, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo, Hideyuki Harada, Toshiaki Takahashi
Introduction: Data on the efficacy and risk of curative-intent chemoradiotherapy in patients with inoperable stage III non-small-cell lung cancer (NSCLC) and interstitial lung disease (ILD) are limited. The aim of this study was to explore the impact of ILD classification on acute exacerbation (AE) of ILD and prognosis in patients with stage III NSCLC and ILD treated with chemoradiotherapy. Materials and methods: We retrospectively reviewed the medical records of patients with stage III NSCLC and ILD treated with curative-intent chemoradiotherapy as the first-line treatment at the Shizuoka Cancer Center between June 2009 and May 2014...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896290/a-study-on-effect-of-oxaliplatin-in-microrna-expression-in-human-colon-cancer
#2
Jasmine Evert, Surajit Pathak, Xiao-Feng Sun, Hong Zhang
Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidated. This study outlines the regulatory effects of oxaliplatin on miRNAs expression in colon cancer cells and correlates it with the changing microRNA expression with p53 and p73 expression status in cells...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896289/detection-of-ctcs-in-portal-vein-was-associated-with-intrahepatic-metastases-and-prognosis-in-patients-with-advanced-pancreatic-cancer
#3
Xiaoyu Liu, Changyu Li, Junhao Li, Tianzhu Yu, Guofeng Zhou, Jiemin Cheng, Guoping Li, Yang Zhou, Wenhui Lou, Xiaolin Wang, Gaoquan Gong, Lingxiao Liu, Yi Chen
Pancreatic cancer is amongst the most lethal malignancies with increasing incidence and mortality worldwide. Distant metastases, especially intrahepatic metastases, is the leading cause of death for pancreatic cancer. Circulating tumor cells (CTCs) are neoplastic cells released from the primary tumor into circulation, and play critical roles in metastases of various types of cancers. Though clinical studies showed that detection of CTCs in peripheral circulation was associated with worse prognosis in patients with breast cancer and hepatocellular carcinoma, detection CTCs in peripheral blood of pancreatic cancer was still challenging due to hepatic filtration and technical limitations...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896288/addition-of-chemotherapy-to-intensity-modulated-radiotherapy-does-not-improve-survival-in-stage-ii-nasopharyngeal-carcinoma-patients
#4
Wang Fangzheng, Jiang Chuner, Sun Quanquan, Ye Zhimin, Liu Tongxin, Liu Jiping, Masoto Sakamoto, Wu Peng, Shi Kaiyuan, Qin Weifeng, Fu Zhenfu, Jiang Yangming
In this study, we examined whether combining neoadjuvant chemotherapy (NAC) and/or concurrent chemotherapy (CC) with intensity-modulated radiotherapy (IMRT) improved survival in patients with stage II nasopharyngeal carcinoma (NPC). Two hundred forty-two stage II NPC patients were enrolled between May 2008 and April 2014 and received radical IMRT with simultaneous integrated boost technique using 6 MV photons; some patient groups also received chemotherapy every 3 weeks for 2-3 cycles. The median follow-up duration was 69 months for all patients...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896287/higher-plasma-fibrinogen-levels-are-associated-with-malignant-phenotype-and-worse-survival-in-patients-with-glioblastomas
#5
Peng-Fei Wang, Zhe Meng, Hong-Wang Song, Kun Yao, Ze-Jun Duan, Shou-Wei Li, Chang-Xiang Yan
Preoperative plasma fibrinogen levels were associated with poor clinical outcomes in malignancies. There were few data about the prognostic value of plasma fibrinogen in glioblastomas (GBMs). The objective of our study was to investigate the association between fibrinogen and patients' clinicopathological factors and overall survival (OS). From 2008 to 2016, 315 patients with GBMs who had a surgical treatment at our institute, were retrospectively involved in this study. IDH (isocitrate dehydrogenase) mutations and ATRX (alpha thalassemia/mental retardation syndrome X-linked) loss were detected with IHC (Immunohistochemistry)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896286/sirt1-promotes-formation-of-breast-cancer-through-modulating-akt-activity
#6
Xiaoxia Jin, Yingze Wei, Feng Xu, Min Zhao, Kui Dai, Rong Shen, Shuyun Yang, Nong Zhang
The silent information regulation factor 1 (sirtuin Type 1, SIRT1), as a kind of NAD+ dependent class III histone deacetylation enzyme, has been found to be involved in tumor proliferation, invasion, and metastasis. The roles of SIRTl in breast cancer is multifaceted depending on its substrate from upstream or downstream signaling pathway. In this study, we sought to make clear the regulating effects of SIRT1 in breast cancer cells, and to explore the underlying mechanisms through which SIRT1 regulates breast cancer...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896285/construction-of-a-human-monoclonal-antibody-against-bfgf-for-suppression-of-nsclc
#7
Sheng Wang, Yiyang Qin, Zhongmin Wang, Junjian Xiang, Yu Zhang, Meng Xu, Baiyong Li, Yu Xia, Peng Zhang, Hong Wang
Compelling evidence implicates that overexpression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor 1 (FGFR1) in non-small cell lung cancer (NSCLC) drives tumor progression, can serve as prognostic biomarkers or therapeutic targets for NSCLC patients. But at present, we still lack of effective drugs for bFGF. The preparation of monoclonal antibodies against bFGF or to understand its mechanism of action is urgently need. Previously, we used hybridoma technology to produce a murine anti-bFGF monoclonal antibody (E12)...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896284/development-of-a-three-gene-prognostic-signature-for-hepatitis-b-virus-associated-hepatocellular-carcinoma-based-on-integrated-transcriptomic-analysis
#8
Yao Yang, Qian Lu, Xuejun Shao, Banghui Mo, Xuqiang Nie, Wei Liu, Xianhua Chen, Yuan Tang, Youcai Deng, Jun Yan
Integration of public genome-wide gene expression data together with Cox regression analysis is a powerful weapon to identify new prognostic gene signatures for cancer diagnosis and prognosis. Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), however, it remains largely unknown about the specific gene prognostic signature of HBV-associated HCC. Using Robust Rank Aggreg (RRA) method to integrate seven whole genome expression datasets, we identified 82 up-regulated genes and 577 down-regulated genes in HBV-associated HCC patients...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896283/from-first-line-to-sequential-treatment-in-the-management-of-metastatic-pancreatic-cancer
#9
REVIEW
Andrés Muñoz Martín, Manuel Hidalgo, Rafael Alvarez, Virginia Arrazubi, Joaquina Martínez-Galán, Mercedes Salgado, Teresa Macarulla, Alfredo Carrato
The current management of patients with metastatic pancreatic ductal adenocarcinoma (mPDAC) is based on systemic chemotherapy. The results of the MPACT and PRODIGE clinical trials have demonstrated that the combination of nab-paclitaxel and gemcitabine (GEM) as well as FOLFIRINOX regimen result in improvement in overall survival when compared to GEM alone. Treatment guidelines now recommend either one of these two regimens as first line treatment for fit patients with mPDAC. Because no head-to-head comparison between the two regimens exists, the selection of one versus the other is based on clinical criteria...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896282/aerosol-immunotherapy-with-or-without-cisplatin-for-metastatic-lung-cancer-non-small-cell-lung-cancer-disease-in-vivo-study-a-more-efficient-combination
#10
Konstantinos Sapalidis, Paul Zarogoulidis, Efstathios Pavlidis, Stella Laskou, Athanasios Katsaounis, Charilaos Koulouris, Dimitrios Giannakidis, Stylianos Mantalovas, Haidong Huang, Chong Bai, Yuting Wen, Li Wang, Chrysanthi Sardeli, Aikaterini Amaniti, Ilias Karapantzos, Chrysanthi Karapantzou, Wolfgang Hohenforst-Schmidt, Fotis Konstantinou, Isaak Kesisoglou, Naim Benhanseen
Lung cancer is the leading cause of cancer death after prostate cancer for males and breast cancer for females. There are novel therapies in the past five years such as; tyrosine kinase inhibitors and most recently in the last two years immunotherapy. Immunotherapy is currently being investigated if it can be administered alone or in combination. Previously we have investigated whether immunotherapy compounds can be produced as aerosols, and in the current study we investigated the safety and efficiency independently of the programmed death-ligand 1...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896281/involvement-of-non-coding-rnas-in-chemotherapy-resistance-of-ovarian-cancer
#11
REVIEW
Yang Shao, Hui Li, Ran Du, Jiao Meng, Gong Yang
Ovarian cancer (OC) is the most lethal gynecological malignancy, with a low 5-year survival rate. Most patients with ovarian cancer are diagnosed in late-stages. A rising number of non-coding RNAs (ncRNAs) have been found to act as key regulators of gene expression by applying novel high-thought methods, such as next generation sequencing (NGS). Non-coding RNAs not only play important roles in carcinogenesis, but also affect the clinical treatment strategies. One of the biggest challenge in OC treatment was chemoresistance, which causes poor prognosis and high recurrence rate after applying traditional remedies...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896280/differences-and-similarities-in-the-phenomenon-of-nets-formation-in-oral-inflammation-and-in-oral-squamous-cell-carcinoma
#12
Marzena Garley, Dorota Dziemiańczyk-Pakieła, Kamil Grubczak, Arkadiusz Surażyński, Dorota Dąbrowska, Wioletta Ratajczak-Wrona, Jolanta Sawicka-Powierza, Jan Borys, Marcin Moniuszko, Jerzy A Pałka, Ewa Jabłońska
Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in patients with cancer occurring in the same location. For preliminary isolation of neutrophils (PMNs), we used Polymorphprep™, then sorted with Microbeads. The cells were recorded in the incubation chamber with a BD Pathway 855 microscope system...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896279/trends-and-outcomes-of-sentinel-lymph-node-biopsy-in-early-stage-vulvar-squamous-cell-carcinoma-a-population-based-study
#13
Juan Zhou, Wen-Wen Zhang, Xue-Ting Chen, San-Gang Wu, Jia-Yuan Sun, Qiong-Hua Chen, Zhen-Yu He
Purpose: To compare trends and outcomes between lymphadenectomy and sentinel lymph node biopsy (SLNB) in node-negative early-stage vulvar squamous cell carcinoma (SCC) using a population-based cancer registry. Methods: Patients with vulvar SCC registered on the Surveillance, Epidemiology, and End Results program between 2003 and 2013 were identified. Statistical analysis was performed using Cox regression proportional hazards to calculate hazard ratio (HR) and 95% confidence interval (CI). A 1:1 propensity score matching (PSM) method was performed to minimize selection bias...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896278/analysis-of-differential-expressions-of-long-non-coding-rnas-in-nasopharyngeal-carcinoma-using-next-generation-deep-sequencing
#14
Xiao-Xiao Li, Xu-Jun Liang, Liu-Ying Zhou, Rui-Jie Liu, Wu Bi, Sai Zhang, Shi-Sheng Li, Wen-Hui Yang, Zhu-Chu Chen, Xin-Ming Yang, Peng-Fei Zhang
Background : Little knowledge about long non-coding RNAs(lncRNAs) in nasopharyngeal carcinoma (NPC) has been acquired. Methods : Next-generation sequencing was applied in 7 cases of NPC tissues and 7 cases of normal tissues in nasopharynx. PLEX, CNCI and CPAT soft-wares were used to predict novel lncRNAs. Real-time Quantitative PCR (qPCR) further validated the data in 20 cases of NPC tissues and 14 cases of normal tissues. Then the cis-regulators and trans-regulators and potential biological functions together with pathways were predicted by Bioinformatics...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896277/-mlh1-promoter-methylation-and-prediction-prognosis-of-gastric-cancer-a-systematic-review-and-meta-and-bioinformatic-analysis
#15
Shixuan Shen, Xiaohui Chen, Hao Li, Liping Sun, Yuan Yuan
Background: The promoter methylation of MLH1 gene and gastric cancer (GC)has been investigated previously. To get a more credible conclusion, we performed a systematic review and meta and bioinformatic analysis to clarify the role of MLH1 methylation in the prediction and prognosis of GC. Methods: Eligible studies were targeted after searching the PubMed, Web of Science, Embase, BIOSIS, CNKI and Wanfang Data to collect the information of MLH1 methylation and GC. The link strength between the two was estimated by odds ratio with its 95% confidence interval...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896276/the-innovative-regularity-and-role-of-p16-methylation-in-blood-during-hcc-development
#16
Cheng-Gang Jiang, Qun Chen, Lina Wu, Guang Wang, Jianzhong Ma
Purpose: This study was performed to examine the regularity and role of p16 methylation in hepatocellular carcinoma (HCC) blood. Methods: Big data of the case-control studies due to blood p16 methylation detection were collected in English and Chinese Journals. The risk of HCC's histologic process was investigated using both Meta-analysis and the quantitative correlation analysis. Results: p16 methylation frequencies in blood were gradually increased from 0 % in normal to 10 % in benign disease, and to 60 % in HCC development...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896275/mycophenolate-mofetil-induces-c-jun-n-terminal-kinase-expression-in-22rv1-cells-an-impact-on-androgen-receptor-signaling
#17
Ondrej Zenata, Zdenek Dvorak, Radim Vrzal
Mycophenolate Mofetil (MYC) is a transplant drug used to prevent rejection in heart and kidneys transplant patients. Inosine monophosphate dehydrogenase (IMPDH), an enzyme involved in de novo synthesis of guanosine nucleotides, was considered as a primary target for MYC. Recently, we described that MYC was activates aryl hydrocarbon receptor and it antagonizes glucocorticoid receptor. Here we describe an androgen receptor (AR) as another off-target for MYC. We found that MYC increased basal and dihydrotestosterone (DHT)-inducible AR-dependent luciferase activity in AIZ-AR cells...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896274/risk-factors-of-the-recurrences-of-pancreatic-solid-pseudopapillary-tumors-a-systematic-review-and-meta-analysis
#18
Hao Gao, Yong Gao, Lingdi Yin, Guangfu Wang, Jishu Wei, Kuirong Jiang, Yi Miao
Background: Pancreatic solid pseudopapillary tumors (SPTs) are rare neoplasms with low-grade malignancy. The main treatment for them is surgical resection. However, some SPTs relapse after resection. The risk factors associated with the recurrences of resected SPTs remain controversial to date. We performed a systematic review and meta-analysis to identify the risk factors of the recurrences of pancreatic SPTs. Materials and Methods: We searched PubMed, EMBASE, and the Cochrane Library from their inception to December 2017...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896273/aberrant-dna-methylation-of-the-p16-apc-mgmt-timp3-and-cdh1-gene-promoters-in-tumours-and-the-surgical-margins-of-patients-with-oral-cavity-cancer
#19
Joanna Katarzyna Strzelczyk, Łukasz Krakowczyk, Aleksander Jerzy Owczarek
Oral cavity cancer is a type of head and neck squamous cell carcinoma (HNSCC) and contributes to significant morbidity and mortality each year. An epigenetic pathway of transcriptional inactivation for many genes has been described in various cancers, including HNSCC. For our study, we selected genes for which silencing caused by hypermethylation can promote cancer development. In 75 primary HNSCC tumours and paired surgical margins, we investigated the methylation status of the p16, APC, MGMT, TIMP3 and CDH1 gene promoters by methylation-specific PCR after bisulphite treatment...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29896272/genomic-and-epigenetic-signatures-associated-with-survival-rate-in-oral-squamous-cell-carcinoma-patients
#20
Ilda Patrícia Ribeiro, Francisco Caramelo, Luísa Esteves, Camila Oliveira, Francisco Marques, Leonor Barroso, Joana Barbosa Melo, Isabel Marques Carreira
Purpose: Although oral squamous cell carcinoma (OSCC) presents great mortality and morbidity worldwide, the mechanisms behind its clinical behavior remain unclear. Biomarkers are needed to forecast patients' survival and, among those patients undergoing curative therapy, which are more likely to develop tumor recurrence/metastasis. Demonstrating clinical relevance of these biomarkers could be crucial both for surveillance and in helping to establish adjuvant therapy strategies. We aimed to identify genomic and epigenetic biomarkers of OSCC prognosis as well as to explore a noninvasive strategy to perform its detection...
2018: Journal of Cancer
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