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Journal of Cancer

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https://www.readbyqxmd.com/read/29581792/inhaled-immunotherapy-administration-for-lung-cancer-efficient-certainly-possible
#1
Konstantinos Sapalidis, Paul Zarogoulidis, Haidong Huang, Chong Bai, Yuting Wen, Li Wang, Konstantina Boniou, Ilias Karapantzos, Chrysanthi Karapantzou, Michael Karanikas, Vasilis Thomaidis, Christoforos Kosmidis, Chrysanthi Sardeli, Naim Benhassen, Yan-Gao Man, Maria C Florou, Stylianos Mantalovas, Stella Laskou, Dimitris Giannakidis, Charilaos Koulouris, Aikaterini Amaniti, Isaak Kesisoglou, Wolfgang Hohenforst-Schmidt
Lung cancer is still diagnosed at a late stage in most lung cancer patients. Regarding Non-small Cell lung cancer there are novel therapies such as; tyrosine kinase inhibitors and immunotherapy. Currently we have two immunotherapies that can be used either as first-line treatment or second line treatment; pembrolizumab and nivolumab. A third one is being investigated as a combination of immunotherapy; ipilimumab. Aerosol treatment has been investigated for many diseases not only for the lung, but also for systematic diseases...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581791/usefulness-of-bronchoscopic-rebiopsy-of-non-small-cell-lung-cancer-with-acquired-resistance-to-epidermal-growth-factor-receptor-tyrosine-kinase-inhibitor
#2
Eun Kyong Goag, Jung Mo Lee, Kyung Soo Chung, Song Yee Kim, Ah Young Leem, Joo Han Song, Ji Ye Jung, Moo Suk Park, Yoon Soo Chang, Young Sam Kim, Joon Chang, Eun Young Kim
Background : Approximately 50% of non-small cell lung cancer (NSCLC) patients with acquired resistance to EGFR-TKI harbor the EGFR mutation T790M. The recent development and wide use of third-generation EGFR-TKIs targeting T790M-mutant NSCLCs have increased the importance of rebiopsy after EGFR-TKI failure. We aimed to investigate the advantages of flexible bronchoscopy as a rebiopsy method and the prevalence of and factors affecting the T790M mutation after EGFR-TKI failure. Methods : We investigated 139 patients who had undergone bronchoscopic rebiopsy and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) between Sep 2014 and Jul 2016...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581790/surgical-treatment-of-combined-hepatocellular-cholangiocarcinoma-is-as-effective-in-elderly-patients-as-it-is-in-younger-patients-a-propensity-score-matching-analysis
#3
Chen-Yang Tao, Wei-Ren Liu, Lei Jin, Zheng Tang, Meng-Xin Tian, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Yuan Fang, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Ying-Hong Shi
Aims: To compare the long-term prognosis of younger and elderly patients with combined hepatocellular-cholangiocarcinoma (CHC) who underwent curative resection between 1993 and 2014 at our center. Methods: Two hundred and thirteen patients who underwent liver resection for CHC were enrolled in our study. The overall survival (OS) and disease-free survival (DFS) of elderly patients (age≥60, n=52) and younger patients (age<60, n=161) were compared by multivariate analysis and propensity score matching (PSM) analysis...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581789/integrated-oncogenomic-profiling-of-copy-numbers-and-gene-expression-in-lung-adenocarcinomas-without-egfr-mutations-or-alk-fusion
#4
Yanzhuo Luo, Bingjin Li, Guangxin Zhang, Yuxiao He, Jeeyoo Hope Bae, Fengping Hu, Ranji Cui, Runhua Liu, Zhou Wang, Lizhong Wang
Targeted therapies based on EGFR mutations or on the ALK fusion oncogene have become the standard treatment for certain patients with lung adenocarcinoma (LUAD). However, most LUAD patients have no EGFR mutation or ALK fusion, and their oncogenetic alterations remain to be characterized. Here we conducted an integrated analysis of public datasets to assess the genomic alterations of 23 highly lung cancer-associated genes. The copy numbers of these genes were measured in ten micro-dissected, paired tumors and normal lung tissues of LUAD patients without EGFR mutations or ALK fusion...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581788/increased-he4-mrna-expression-correlates-with-high-level-of-eif3a-mrna-and-better-survival-in-women-with-epithelial-ovarian-cancer
#5
Chen-Hui Luo, Min Zhao, Yu-Xi Tang, Shohreh Shahabi, Kai-Ning Fang, Yan Chen, Yan Tang, Xiao-Yan Chen, Jing Wang, Hong-Hao Zhou
Human epididymis protein 4 (HE4) is one of the most promising biomarkers for epithelial ovarian cancer (EOC). The majority of previous studies utilized the serum level or tissue protein expression of HE4 based upon immunohistochemistry (IHC) to evaluate the role of HE4 in the diagnosis, prognosis, and surveillance of EOC, but very little is known about HE4 mRNA expression. Eukaryotic translation initiation factor 3a (eIF3a) is implicated in oncogenesis and has been investigated extensively as a potential biomarker for malignancy...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581787/sult1e1-inhibits-cell-proliferation-and-invasion-by-activating-ppar%C3%AE-in-breast-cancer
#6
Yali Xu, Xiaoyan Lin, Jiawen Xu, Haiyan Jing, Yejun Qin, Yintao Li
Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which is involved in tumorigenesis and the progression of breast and endometrial cancers. Our previous study has shown that the protein levels of SULT1E1 were decreased in breast cancer; however, the underlying mechanism is still poorly understood. In this study, we explored the functional and molecular mechanisms by which SULT1E1 influenced breast cancer. Here, we identified that overexpression of SULT1E1 inhibited breast cancer cell growth through inducing apoptosis and arresting cell cycle progression...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581786/genetic-variations-in-the-pi3k-pten-akt-mtor-pathway-predict-tumor-response-and-disease-free-survival-in-locally-advanced-rectal-cancer-patients-receiving-preoperative-chemoradiotherapy-and-radical-surgery
#7
Jianhong Peng, Wenjuan Ma, Zhongguo Zhou, Yangkui Gu, Zhenhai Lu, Rongxin Zhang, Zhizhong Pan
Objective: Although preoperative chemoradiotherapy (CRT) followed by total mesorectal excision (TME) is the standard treatment for locally advanced rectal cancer (LARC), the clinical efficacy differs among patients. This study was conducted to determine the association between genetic variations in the PI3K/PTEN/AKT/mTOR pathway and clinical outcomes in LARC patients. Methods: Sixteen tagging single-nucleotide polymorphisms (SNPs) in five core genes (PIK3CA, PTEN, AKT1, AKT2, and FRAP1) were genotyped. The associations of these SNPs with tumor response to preoperative CRT, postoperative disease-free survival (DFS) and overall survival (OS) were identified...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581785/a-meta-analysis-methylenetetrahydrofolate-reductase-c677t-polymorphism-in-gastric-cancer-patients-treated-with-5-fu-based-chemotherapy-predicts-serious-hematologic-toxicity-but-not-prognosis
#8
Cheng Tang, Shan Yu, Huiqin Jiang, Wei Li, Xiaojing Xu, Xi Cheng, Ke Peng, Erbao Chen, Yuehong Cui, Tianshu Liu
5-fluorouracil (5-Fu) metabolism associated enzyme, methylenetetrahydrofolate reductase (MTHFR)'s polymorphism C677T can affect enzyme activity and a series of studies have been performed to examine the association of this MTHFR polymorphism with the clinical outcomes of gastric cancer (GC) patients treated with 5-Fu based chemotherapies. However, the results are inconsistent and inconclusive. Therefore, a more comprehensive summary like meta-analysis on this topic is needed. We performed a systematic literature search of PubMed and Embase up to May 20, 2017...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581784/autophagy-inhibition-stimulates-apoptosis-in-oesophageal-squamous-cell-carcinoma-treated-with-fasudil
#9
Fa-Jun Xie, Qiu-Qing Zheng, Jing Qin, Ling-Ling Zhang, Na Han, Wei-Min Mao
Fasudil has been proven to be a promising chemotherapeutic drug for various malignancies. However, the potential anticancer effects of fasudil in oesophageal squamous cell carcinoma (ESCC) remain to be established. We confirmed the RhoA activity is inhibited by fasudil in ESCC cells. Then measured the effects of fasudil on apoptosis and autophagy in ESCC. Our study showed fasudil could both induce ESCCs apoptosis and autophagy, and when fasudil-induced autophagy was inhibited by knockdown of the essential autophagy genes (Beclin 1 or ATG7), and pharmacologic agent (chloroquine) treatment, both treatments also significantly sensitized ESCC to fasudil-induced apoptosis, reducing cell viability in vitro...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581783/effect-of-the-oncolytic-echo-7-virus-rigvir%C3%A2-on-the-viability-of-cell-lines-of-human-origin-in-vitro
#10
Andra Tilgase, Liene Patetko, Ilze Blāķe, Anna Ramata-Stunda, Mārtiņš Borodušķis, Pēteris Alberts
Background: The role of oncolytic viruses in cancer treatment is increasingly studied. The first oncolytic virus (Rigvir®, ECHO-7) was registered in Latvia over a decade ago. In a recent retrospective study Rigvir® decreased mortality 4.39-6.57-fold in stage IB-IIC melanoma patients. The aims of the present study are to test the effect of Rigvir® on cell line viability in vitro and to visualize the cellular presence of Rigvir® by immunocytochemistry. Methods: The cytolytic effect of Rigvir® on the viability of FM-9, RD, AGS, A549, HDFa, HPAF‑II, MSC, MCF7, HaCaT, and Sk-Mel-28 cell lines was measured using live cell imaging...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581782/a-novel-risk-prediction-model-for-patients-with-combined-hepatocellular-cholangiocarcinoma
#11
Meng-Xin Tian, Wen-Jun He, Wei-Ren Liu, Jia-Cheng Yin, Lei Jin, Zheng Tang, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Chen-Yang Tao, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Ying-Hong Shi
Backgrounds: Regarding the difficulty of CHC diagnosis and potential adverse outcomes or misuse of clinical therapies, an increasing number of patients have undergone liver transplantation, transcatheter arterial chemoembolization (TACE) or other treatments. Objective: To construct a convenient and reliable risk prediction model for identifying high-risk individuals with combined hepatocellular-cholangiocarcinoma (CHC). Methods: 3369 patients who underwent surgical resection for liver cancer at Zhongshan Hospital were enrolled in this study...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581781/lass2-regulates-invasion-and-chemoresistance-via-erk-drp1-modulated-mitochondrial-dynamics-in-bladder-cancer-cells
#12
Lijuan Huang, Ting Luan, Yujin Chen, Xin Bao, Yinglong Huang, Shi Fu, Haifeng Wang, Jiansong Wang
Mitochondria coordinated a lot of vital cellular processes of energy production and distribution. Change of mitochondrial functions has been implicated in cancer progression. The present study aims to investigate the involvement of mitochondria dynamics in LASS2 induced invasion and chemoresistance of bladder cancer cells. J82 and BIU87 cell lines were used for LASS2 plasmid transfection while siRNA knockdown was carried out in 5637 cell line. Matrigel invasion assay and Annexin V/PI staining demonstrated that LASS2 negatively regulated cancer cell invasion and chemoresistance...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581780/switch-of-the-ovarian-cancer-cell-to-a-calcifying-phenotype-in-the-calcification-of-ovarian-cancer
#13
Jirui Wen, Zhiwei Zhao, Liwei Huang, Liang Li, Jiman Li, Ye Zeng, Jiang Wu, Yali Miao
OBJECTIVE: The main aim of this study was to study swith of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer, and to offer some help for ovarian cancer's diagnosis and differentiation therapy. METHODS: The mineralization of ovarian cancer cell lines SKOV3 was induced via calcification medium for 21 d in vitro . Alizarin red staining, von kossa staining, calcein fluorescence staining and ALP activity detection were used to identify mineralization in calcification model of ovarian cancer...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581779/idh1-2-mutations-predict-shorter-survival-in-chondrosarcoma
#14
Iwona Lugowska, Pawel Teterycz, Michal Mikula, Maria Kulecka, Anna Kluska, Aneta Balabas, Magdalena Piatkowska, Michal Wagrodzki, Andrzej Pienkowski, Piotr Rutkowski, Jerzy Ostrowski
Background . Recent studies have shown that isocitrate dehydrogenase 1/2 ( IDH1/2 )- activating mutations occur in a variety of cancers, including acute myeloid leukaemia, gliomas, and chondrosarcomas (CHS)s. The effect of IDH1/2 mutation on overall survival (OS) has not been reported in CHS. The aim of our study was to assess the prevalence of known cancer-related gene mutations in CHS, as well as their prognostic role in patient survival. Methods . DNA from FFPE samples of 80 patients (F:M- 1:1.3; mean age: 58 years; range 27-86) with histologically confirmed CHS (G1:29; G2:34; G3:17) was subjected to library preparation with the Ion AmpliSeq Cancer Hotspot Panel v2 and sequenced on the PGM Ion Torrent...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581778/the-anti-tumor-effects-of-dual-pi3k-mtor-inhibitor-bez235-and-histone-deacetylase-inhibitor-trichostatin-a-on-inducing-autophagy-in-esophageal-squamous-cell-carcinoma
#15
Ning Wu, Yingfeng Zhu, Xiao Xu, Yongjun Zhu, Yang Song, Liewen Pang, Zhiming Chen
The effect and regulation of autophagy-related proteins Beclin-1 and LC3 in esophageal squamous cell carcinoma have not been fully studied. The aim of this study was to assess the expression of Beclin-1 and LC3 in ESCCs, and to investigate the association between the two markers and clinicopathological characteristics as well as prognosis. Meanwhile, we explored the anti-tumor effect of the PI3K/mTOR dual inhibitor BEZ235 and the histone deacetylase inhibitor TSA on inducing autophagy in ESCC cells. Our study included 118 ESCC tumors and paired non-tumor esophageal mucosa tissues...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581777/prospective-matched-study-on-comparison-of-volumetric-modulated-arc-therapy-and-intensity-modulated-radiotherapy-for-nasopharyngeal-carcinoma-dosimetry-delivery-efficiency-and-outcomes
#16
Bin-Bin Chen, Shao-Min Huang, Wei-Wei Xiao, Wen-Zhao Sun, Ming-Zhu Liu, Tai-Xiang Lu, Xiao-Wu Deng, Fei Han
Background: The purpose of this study is to assess the feasibility of volumetric-modulated arc therapy (VMAT) for nasopharyngeal carcinoma (NPC) patients by comparing the physical dosimetry, delivery efficiency and clinical outcomes with intensity-modulated radiotherapy (IMRT). Methods: A prospective matched study was performed for patients with newly diagnosed NPC who underwent VMAT or IMRT. The patients in two groups were equally matched in terms of gender, age, tumor stage and chemotherapy. The target coverage, homogeneity index (HI) and conformity index (CI) of the planning target volume (PTV), organs at risk (OARs) sparing, average treatment time and clinical outcomes were analyzed...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581776/association-of-smoking-and-xpg-cyp1a1-ogg1-ercc5-ercc1-mmp2-and-mmp9-gene-polymorphisms-with-the-early-detection-and-occurrence-of-laryngeal-squamous-carcinoma
#17
Yi Zhu, Luo Guo, ShengZi Wang, Qun Yu, JianXiong Lu
A total of 200 smoking-related laryngeal carcinoma patients with pathology confirmation from the Eye and ENT Hospital and 190 high-risk smokers were included in a survey. All of the participants had a smoking index greater than 400 (cigarettes/day*year.) We obtained data on clinical and baseline characteristics, and peripheral blood was obtained and subjected to DNA extraction to analyse the correlation between smoking and the occurrence of laryngeal carcinoma. We selected candidate genes and SNP fragments that were found to be closely associated with smoking-related tumours in preliminary studies...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581775/increased-paxillin-expression-in-prostate-cancer-is-associated-with-advanced-pathological-features-lymph-node-metastases-and-biochemical-recurrence
#18
Qing-Shui Zheng, Shao-Hao Chen, Yu-Peng Wu, Hui-Jun Chen, Hong Chen, Yong Wei, Xiao-Dong Li, Jin-Bei Huang, Xue-Yi Xue, Ning Xu
Purpose Paxillin regulates cell-cell adhesion, and altered Paxillin expression has been associated with human carcinogenesis. This study analyzed the association between Paxillin expression in prostate cancer (PCa) tissues with clinicopathological features, lymph node metastasis and biochemical PCa recurrence. Methods A total of 386 tissue specimens from PCa patients who received radical prostatectomy and 60 tissue specimens from benign prostatic hyperplasia (BPH) cases were collected to construct tissue microarrays, which were subsequently immunostained for Paxillin expression...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581774/tumor-location-is-an-independent-predictive-factor-for-distant-metastasis-and-metastatic-sites-of-rectal-adenocarcinoma-in-patients-receiving-total-mesorectal-excision
#19
Chien-Hsin Chen, Mao-Chih Hsieh, Ping-Kun Hsiao, En-Kwang Lin, Yen-Jung Lu, Szu-Yuan Wu
Background and Objectives : To evaluate the predictive factor for and patterns of distant metastasis in patients with rectal adenocarcinoma receiving total mesorectal excision (TME). Methods : We enrolled 217 consecutive patients who had histologically confirmed rectal adenocarcinoma and underwent surgery at Taipei Medical University- Wanfang Hospital between January 2000 and December 2014. TME was performed in all patients undergoing a sphincter-sparing procedure or abdominal perineal resection of rectal cancer...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581773/epigenetic-modification-of-sall1-as-a-novel-biomarker-for-the-prognosis-of-early-stage-head-and-neck-cancer
#20
Kiyoshi Misawa, Yuki Misawa, Atsushi Imai, Daiki Mochizuki, Shiori Endo, Masato Mima, Ryuji Ishikawa, Hideya Kawasaki, Takashi Yamatodani, Takeharu Kanazawa
This study examined Sal-like protein ( SALL)1 methylation profiles in head and neck squamous-cell carcinoma (HNSCC) patients at diagnosis and follow-up, and evaluated their prognostic significance and value as a biomarker. SALL1 expression was examined in a panel of cell lines by quantitative reverse transcription PCR (qRT-PCR). Promoter methylation was determined by quantitative methylation-specific polymerase chain reaction (qMSP) and was compared to the clinical characteristics of 205 samples. SALL1 promoter methylation was associated with transcriptional inhibition and was correlated with disease recurrence in 31...
2018: Journal of Cancer
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