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Journal of Cancer

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https://www.readbyqxmd.com/read/27877233/the-impact-of-clinical-stage-on-radiation-doses-to-organs-at-risk-following-intensity-modulated-radiotherapy-in-nasopharyngeal-carcinoma-a-prospective-analysis
#1
Lin Xu, Ji-Jin Yao, Guan-Qun Zhou, Wang-Jian Zhang, Guo-Long Liu, Li-Zhi Liu, Jun Ma, Ying Sun
Background: The development of intensity-modulated radiotherapy (IMRT) has revolutionized the management of nasopharyngeal carcinoma (NPC). The purpose of this study was to investigate the impact of clinical stage on radiation doses to organs at risk (OARs) in NPC. Material and Methods: One hundred and forty-eight patients with newly diagnosed and untreated NPC were prospectively enrolled. Based on the anatomic definition and pathogenesis of radiation induced injury, a total of 28 OARs surrounding the nasopharynx were contoured on axial computed tomography (CT) planning images in each patient...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877232/a-novel-prognostic-score-based-on-preoperative-nutritional-status-predicts-outcomes-of-patients-after-curative-resection-for-gastric-cancer
#2
Xuechao Liu, Haibo Qiu, Jianjun Liu, Shangxiang Chen, Dazhi Xu, Wei Li, Youqing Zhan, Yuanfang Li, Yingbo Chen, Zhiwei Zhou, Xiaowei Sun
PURPOSE: We aimed to determine whether preoperative nutritional status (PNS) was a valuable predictor of outcome in patients with gastric cancer (GC). METHODS: We retrospectively evaluated 1320 patients with GC undergoing curative resection. The PNS score was constructed based on four objective and easily measurable criteria: prognostic nutritional index (PNI) score 1, serum albumin <35 g/L, body mass index (BMI) <18.5 kg/m(2), or preoperative weight loss ≥5% of body weight. The PNS score was 2 for patients who met three or four criteria, 1 for those who met one or two criteria, and 0 for those who didn't meet all of these criteria...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877231/chemomodulatory-potential-of-bartogenic-acid-against-dmba-croton-oil-induced-two-step-skin-carcinogenesis-in-mice
#3
Chandragouda R Patil, Bhavin M Sonara, Umesh B Mahajan, Kalpesh R Patil, Dipak D Patil, Ramchandra B Jadhav, Sameer N Goyal, Shreesh Ojha
Barringtonia racemosa fruits are believed to be useful in cancer treatment in Ayurveda, the Indian system of medicine. In present study, bartogenic acid (BA), a triterpenoid constituent of Barringtonia fruits was evaluated for its cytotoxicity property using the human skin carcinoma cell line (SCC-13) and human peripheral blood mononuclear cells (PBMC). The chemopreventive efficacy of BA was evaluated against the DMBA/Croton oil-induced skin carcinogenesis in mice.BA was orally administered at the doses of 1, 2 or 4 mg/kg/day or applied topically every day for 12 weeks following DMBA application...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877230/transcriptional-cofactor-mask2-is-required-for-yap-induced-cell-growth-and-migration-in-bladder-cancer-cell
#4
Liang Dong, Fan Lin, Wanjun Wu, Weiren Huang, Zhiming Cai
The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in bladder cancer, we overexpress YAP in bladder cancer cells and discover that YAP is able to promote bladder cancer cell growth and migration. In addition, we provide evidence that knockdown of Mask2 is able to repress bladder cancer cell growth and migration...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877229/co-expression-of-achaete-scute-homologue-1-and-calcitonin-gene-related-peptide-during-nnk-induced-pulmonary-neuroendocrine-hyperplasia-and-carcinogenesis-in-hamsters
#5
Xu Naizhen, R Ilona Linnoila, Shioko Kimura
Achaete-scute homologue-1 or ASCL1 (MASH1, hASH1) plays roles in neural development and pulmonary neuroendocrine (NE) differentiation, and it is expressed in certain lung cancers. This study was aimed to assess whether and/or how ASCL1 plays a role in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced pulmonary NE hyperplasia and carcinogenesis in hamsters. Hamsters were injected 3 times weekly with either NNK or solvent alone (control) for treatment periods of 6 and 24 weeks, both without and with 6-week recovery...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877228/lymphangiogenesis-in-classical-hodgkin-lymphoma-preliminary-study-with-clinicopathological-correlations
#6
Daniel Benharroch, Isebrand Prinsloo, Jacob Gopas, Irena Lazarev
A role for lymphangiogenesis in metastatic breast and prostate cancers has been suggested recently. The relevance of lymphangiogenesis in cancer as a rule, and more specifically in classical Hodgkin lymphoma, is poorly understood in comparison with that of angiogenesis. In a preliminary (pilot) study we have investigated the role of lymphatic vessels growth in 19 cases of classical Hodgkin lymphoma stained with the D2-40 (podoplanin) antibody. In each case, three lymphatic vessels hot spots were scrutinized twice...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877227/incidence-and-predictors-of-bone-metastases-bm-and-skeletal-related-events-sres-in-small-cell-lung-cancer-sclc-a-swiss-patient-cohort
#7
Katrin Conen, Raphael Hagmann, Viviane Hess, Alfred Zippelius, Sacha I Rothschild
Objectives: Bone metastases (BM) and skeletal-related events (SREs) are frequent complications in patients with lung cancer. Whereas in non-small-cell lung cancer (NSCLC) incidence, prognostic impact, and risk factors are well established, there is only little knowledge in patients with small cell lung cancer (SCLC). We retrospectively evaluated the incidence of BM, SRE and their treatment in a SCLC patient cohort treated at our hospital. We further assessed the role of Lactate Dehydrogenase (LDH), a possible predictor of BM development in SCLC patients...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877226/rac1-overexpression-is-correlated-with-epithelial-mesenchymal-transition-and-predicts-poor-prognosis-in-non-small-cell-lung-cancer
#8
Yujuan Zhou, Qianjin Liao, Yaqian Han, Jie Chen, Zhigang Liu, Hang Ling, Jing Zhang, Wenjuan Yang, Linda Oyang, Longzheng Xia, Li Wang, Heran Wang, Lei Xue, Hui Wang, Bingqiang Hu
Objective: Ras-related C3 botulinum toxin substrate1(Rac1) and epithelial mesenchymal transition (EMT) are key therapeutic targets in cancer. We investigated the clinical significance of Rac1 and markers of EMT expression in non-small cell lung cancer (NSCLC), and their possible correlation with EMT phenotype. Methods: Immunohistochemistry was used to assess the expression of Rac1, Snail1, Twist1, N-cadherin (N-cad), Vimentin (Vim), and E-cadherin (E-cad) in 153 NSCLC paraffin-embedded specimens and 45 normal specimens adjacent to tumors...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877225/anti-cancer-and-sensibilisation-effect-of-triptolide-on-human-epithelial-ovarian-cancer
#9
Hui Hu, Liping Luo, Fei Liu, Danghua Zou, Sihong Zhu, Buzhen Tan, Tingtao Chen
Introduction: Advanced ovarian cancer is the main cause of ovarian cancer deaths, and it is important to seek safe and effective phytochemicals to suppress cancer or lower the chemotherapy resistance of ovarian cancer. Methods: This study evaluated the effect of Triptolide (TPL) on the proliferation, cycle distribution, apoptosis, and ultra-structure of COC1/DDP cells in vitro, as well as the anti-cancer effect and sensibilisation effect of TPL in vivo. Results: The results indicated that TPL could significantly inhibit the growth of COC1/DDP cells (P<0...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877224/the-role-of-copper-transporter-atp7a-in-platinum-resistance-of-esophageal-squamous-cell-cancer-escc
#10
Zhuang-Hua Li, Rongjie Zheng, Jing-Tang Chen, Jun Jia, Miaozhen Qiu
Purpose: Platinum derivatives, such as cisplatin (DDP), carboplatin and oxaliplatin, are widely used components of modern cancer chemotherapy including esophageal squamous cell cancer (ESCC). However, their roles are limited by the impact of intrinsic/acquired resistance mechanisms on tumor responses. Recent studies have shown that the mammalian copper transporters CTR1, ATP7A and ATP7B are involved in cisplatin-resistance to some cancers. Methods: The cytotoxicities of DDP in different cell lines were determined using the MTT assay...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877223/prognostic-impact-of-hormone-receptor-and-her2-defined-subtypes-in-inflammatory-breast-cancer-treated-with-high-dose-chemotherapy-a-retrospective-study
#11
Laurys Boudin, Anthony Gonçalves, Patrick Sfumato, Renaud Sabatier, François Bertucci, Carole Tarpin, Magali Provansal, Gilles Houvenaeghel, Eric Lambaudie, Agnes Tallet, Michel Resbeut, Emmanuelle Charafe-Jauffret, Boris Calmels, Claude Lemarie, Jean-Marie Boher, Jean-Marc Extra, Patrice Viens, Christian Chabannon
Purpose: Studies examining high-dose chemotherapy with autologous hematopoietic stem cell transplantation (HDC-AHSCT) strategies in inflammatory breast cancer (IBC), showed encouraging results in terms of disease-free survival (DFS), and overall survival (OS). The lack of data regarding HER2 status in all of these studies prevented any prognostic analysis involving breast cancer subtypes. Methods: All consecutive female patients treated for IBC with HDC and AHSCT at Institut Paoli-Calmettes between 2003 and 2012 were included...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877222/hedgehog-signaling-non-canonical-activated-by-pro-inflammatory-cytokines-in-pancreatic-ductal-adenocarcinoma
#12
Yuqiong Wang, Gang Jin, Quanjiang Li, Zhiping Wang, Weimin Hu, Ping Li, Shude Li, Hongyu Wu, Xiangyu Kong, Jun Gao, Zhaoshen Li
Hedgehog(HH) pathway is found to be activated through a manner of canonical, or the non-canonical HH pathways. Distinct hyperplasia stroma around tumor cells is supposed to express pro-inflammatory cytokines abundantly, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), etc. in pancreatic ductal adenocarcinoma (PDAC) tissues. In this study we observed the effects of TNF-α and IL-1β on HH pathway activation in PDAC cells, and explored their activation manners. Our results showed that pro-inflammatory cytokines, TNF-α and IL-1β, could up-regulate the expression of GLI1 gene, increase its nuclear protein expression and promote malignant cell behaviors including migration, invasion, epithelial-mesenchymal transition (EMT) and drug resistance as well...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877221/the-impact-of-diabetes-on-the-risk-of-prostate-cancer-development-according-to-body-mass-index-a-10-year-nationwide-cohort-study
#13
Jin Bong Choi, Hyong Woo Moon, Young Hyun Park, Woong Jin Bae, Hyuk Jin Cho, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Kyung-Do Han, U-Syn Ha
Purpose: We examined the association between obesity and prostate cancer both with and without diabetic patients included in the analysis using nationally representative data of the Korean population from the National Health Insurance System (NHIS). Materials and Methods: Of the 424,712 participants who underwent health examinations in 2002-2008, 139,519 men ≥40 years old and without prostate cancer were followed from the beginning of 2002 to the end of 2012. Multivariate adjusted Cox regression analysis was conducted to examine the hazard ratio (HR) and 95% confidence interval (CI) for the association between prostate cancer and body mass index (BMI) both with and without diabetes...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877220/aib1-genomic-amplification-predicts-poor-clinical-outcomes-in-female-glioma-patients
#14
Lihong Chen, Changwei Wang, Xinyuan Zhang, Ke Gao, Rui Liu, Bingyin Shi, Peng Hou
Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas as control subjects were enrolled, and the copy number of AIB1 was analyzed in these samples. In addition, we explored potential correlation of AIB1 amplification with clinicopathological characteristics and clinical outcomes of glioma patients...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877219/an-overview-of-genetic-changes-and-risk-of-pancreatic-ductal-adenocarcinoma
#15
REVIEW
Agnieszka K Sarnecka, Malgorzata Zagozda, Marek Durlik
The pancreatic carcinoma is a leading cause of death in cancer carriers worldwide. The early diagnostic is difficult due to late stage during diagnosis, lack of characteristic symptoms and also multifactor basis. In cancer development take part both, environmental and genetic factors, alone or in conjunction with each other. The nonspecific biomarkers of cancers are a reason for the search for more accurate factors which allow for fast and personalized diagnostics. Some of cancers have identified molecular (metabolic, biochemical or genetic) markers but in most cases the only clue is patient`s interview and abnormal levels of organ functions markers...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877218/vitamin-d3-intake-dose-and-common-cancer-a-population-based-case-control-study-in-a-chinese-population
#16
Henry Wc Leung, Chih-Hsin Muo, Chung-Feng Liu, Agnes Lf Chan
Objectives: Epidemiological studies suggest that vitamin D status is associated inversely with risk of common cancers in western populations. This study aimed to investigate whether vitamin D is associated with risk of common cancers in Chinese population. Methods: A population-based retrospective case-control study was conducted analyzing data retrieved from the Catastrophic Illness Patient Databases (CIPD) and longitudinal health insurance database (LHID) from January 1, 2010 to December 31, 2011and January 1, 2000 to December 31, 2011, respectively...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877217/pregnancy-specific-%C3%AE-1-glycoprotein-1-is-expressed-in-pancreatic-ductal-adenocarcinoma-and-its-subcellular-localization-correlates-with-overall-survival
#17
Jasmin H Shahinian, Hannah Fuellgraf, Stefan Tholen, Justin Mastroianni, Julia Daniela Knopf, Markus Kuehs, Bettina Mayer, Manuel Schlimpert, Birte Kulemann, Simon Kuesters, Jens Hoeppner, Ulrich F Wellner, Martin Werner, Ulrich T Hopt, Robert Zeiser, Peter Bronsert, Oliver Schilling
Proteins of the pregnancy specific β-1 glycoprotein (PSG) family are renowned for their elevated expression during pregnancy. Only few reports have investigated their expression in adenocarcinomas. We studied the expression of PSG1 in pancreatic adenocarcinoma (PDAC). In a cohort of 104 patient samples, immunohistochemical analysis determined PSG1 expression in every specimen. PSG1 was found at apical and cytoplasmic localization or solely at cytoplasmic localization, with the latter case being correlated to shortened median survival (25 vs 11 months, logrank p-value < 0...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877216/investigating-a-correlation-between-chemoradiotherapy-schedule-parameters-and-overall-survival-in-a-real-life-ld-sclc-patient-cohort
#18
Farkhad Manapov, Chukwuka Eze, Maximilian Niyazi, Olarn Roengvoraphoj, Minglun Li, Nina-Sophie Hegemann, Guido Hildebrandt, Rainer Fietkau, Claus Belka
Background: Chemoradiotherapy (CRT) is a treatment standard in limited disease (LD) small cell lung cancer (SCLC). Currently, the timing of thoracic radiation therapy (TRT) remains the subject of randomised trials and meta-analyses. To investigate a correlation between CRT schedule parameters and overall survival (OS) in a real-life patient cohort, a temporal analysis was performed. Methods: 182 LD SCLC patients successfully treated with definitive CRT were retrospectively reviewed. TRT was applied concurrently or sequentially...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877215/the-c-reactive-protein-albumin-ratio-is-an-independent-prognostic-factor-for-overall-survival-in-patients-with-nasopharyngeal-carcinoma-receiving-intensity-modulated-radiotherapy
#19
Chang-Juan Tao, Yuan-Yuan Chen, Feng Jiang, Xing-Lai Feng, Qi-Feng Jin, Ting Jin, Yong-Feng Piao, Xiao-Zhong Chen
This study aims to investigate the prognostic value of the C-reactive protein/albumin (CRP/ALB) ratio in nasopharyngeal carcinoma (NPC) in the intensity-modulated radiotherapy (IMRT) era. A total of 719 patients with NPC treated between January 2007 and December 2012 were retrospectively reviewed. Serum albumin and CRP levels were measured before treatment. The associations between the CRP/ALB ratio and clinicopathological parameters were analyzed. Multivariate analyses using the Cox proportional hazards model were performed to identify significant prognostic factors associated with overall survival (OS)...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27877214/role-of-urinary-biomarkers-in-the-diagnosis-of-adenoma-and-colorectal-cancer-a-systematic-review-and-meta-analysis
#20
REVIEW
Emma Altobelli, Paolo Matteo Angeletti, Giovanni Latella
The growing interest in enhancing and spreading colorectal cancer (CRC) screening has been stimulating the exploration of novel biomarkers with greater sensitivity and specificity than immunochemical faecal occult blood test (iFOBT). The present study provides i) a systematic review of the urinary biomarkers that have been tested to achieve early CRC diagnosis and assess the risk of colorectal adenoma and adenocarcinoma, and ii) a meta-analysis of the data regarding the urinary prostaglandin (PG) metabolite PGE-M...
2016: Journal of Cancer
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