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Journal of Cancer

Renfei Zhu, Cheng Gao, Liuhua Wang, Guoxin Zhang, Weiming Zhang, Zhihong Zhang, Lizong Shen, Shoulin Wang
Background: Persistent Helicobacter pylori ( H. pylori ) infection leads to various gastric diseases. Multiple studies have demonstrated that aryl hydrocarbon receptor (AHR) plays roles in the antibacterial response and aryl hydrocarbon receptor repressor (AHRR) is downregulated in stomach cancer. However, the role of AHR or AHRR in H. pylori -related gastric diseases remains unclear. Aims: To investigate whether AHR or AHRR is involved in H. pylori -related gastric diseases. Methods: Patients with gastritis or gastric adenocarcinoma were enrolled randomly, and gastric tissue specimens were diagnosed pathologically...
2018: Journal of Cancer
Jing Tao, Zhen-Jian Zhuo, Meng Su, Lizhao Yan, Jing He, Jiao Zhang
Neuroblastoma is a malignant tumor arising from the developing sympathetic nervous system, which mainly affects children. Variations in XPA gene have been shown to confer cancer susceptibility. However, no investigation has been reported regarding the association between XPA polymorphisms and neuroblastoma risk. This study was conducted to measure the association of XPA polymorphisms with neuroblastoma susceptibility in Chinese children. In this hospital-based case-control study with 393 cases and 812 controls, we genotyped two polymorphisms (rs1800975 T>C, and rs3176752 G>T) in XPA gene to access their contributions to neuroblastoma risk by TaqMan methods...
2018: Journal of Cancer
Li-Ye Shi, Jiang Liu, Lu-Jiao Yu, Yi-Ming Lei, Sean X Leng, Hai-Yan Zhang
Purpose: Age at diagnosis has been identified as a major determinant of thyroid cancer-specific survival. But the cut-off value for age was controversial. The interaction among gender, age and histologic subtypes needed to be answered. Methods: We identified 59,892 thyroid cancer (TC) patients from the Surveillance, Epidemiology, and End Results (SEER) database. We divided the patients into the following three groups according to age: 20-44 years (young), 45-64 years (middle-aged), and ≥ 65 years (elderly)...
2018: Journal of Cancer
Dejiao He, Xuan Sun, Hongxia Yang, Xiaoli Li, Dingping Yang
Cancer cells usually have a high requirement for fatty acids in order to meet the rapid proliferation and metabolism. Acetyl-CoA carboxylase-α(ACCA) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and has been a rate-limiting enzyme in the synthesis of long chain fatty acid and cellular energy storage. 5-tetradecyloxy-2-furoic acid (TOFA) is well known as an allosteric inhibitor of ACCA. In this study, we examined the functions of TOFA in human renal cell carcinoma (RCC) cell lines ACHN and 786-O...
2018: Journal of Cancer
Yi-Meng Duan, Ying Jin, Meng-Li Guo, Leng-Xin Duan, Jian-Gang Wang
Gecko ( Gekko japonicus ) extracts have been used in traditional Chinese medicine for many years. It has been proven that the gecko polypeptide mixture (GPM) extracted from gecko can inhibit the growth of multiple types of tumor cells. In order to investigate the possible anti-tumor molecular mechanisms of GPM, we used RNA-seq technology to identify the differentially expressed genes (DEGs) of human hepatocellular carcinoma (HCC) HepG2 cells treated with or without GPM. MTT assay was used to detect the viability of HepG2 cells...
2018: Journal of Cancer
Yalu Zhang, Rundong Zhang, Guopei Luo, Kaixing Ai
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most common causes of cancer-related death. Recently, long noncoding RNAs (lncRNAs) have emerged as significant regulators in numerous cancers, including PDAC. LncRNA small nucleolar RNA host gene 1 (SNHG1) has been reported in the development of several tumors, but the biological roles of it in PDAC remain to be illuminated. This study aims to investigate the function of lncRNA SNHG1, revealing its molecular mechanism and clinical significance in PDAC...
2018: Journal of Cancer
Tamotsu Sugai, Noriyuki Uesugi, Yuriko Kitada, Noriyuki Yamada, Mitsumasa Osakabe, Makoto Eizuka, Ryo Sugimoto, Yasuko Fujita, Keisuke Kawasaki, Eiichiro Yamamoto, Hiroo Yamano, Hiromu Suzuki, Takayuki Matsumoto
Objective: Recent studies have shown that cancer-associated fibroblasts (CAFs) and the epithelial-mesenchymal transition (EMT) play important roles in the progression and metastasis of CRC. Although prediction of lymph node metastasis in submucosal invasive colorectal cancer (SiCRC) is important, the relationships of CAF and EMT with lymph node metastasis of SiCRC have not yet been examined. Here, we aimed to analyze the expression patterns of CAF- and EMT-related proteins in SiCRC. Materials and Methods: The expression of CAF-related markers, including α-smooth muscle actin, CD10, podoplanin, fibroblast specific protein 1, and adipocyte enhancer-binding protein 1, and EMT-related proteins [zinc finger protein SNAI2 (ZEB1) and twist-related protein 1 (TWIST1) in SiCRC with (n = 29) or without (n = 80) lymph node metastasis was examined by immunohistochemistry...
2018: Journal of Cancer
Liu Yang, Yang Guo, Xin Liu, Tongtong Wang, Xiangmin Tong, Kefeng Lei, Jiahui Wang, Dongsheng Huang, Qiuran Xu
MicroRNAs (miRNAs) have been recognized as key regulators of tumorigenesis and progression. Serum miR-302c-3p expression is prominently deregulated in HCV-related hepatocellular carcinoma (HCC). However, the expression of miR-302c-3p and its functional role in HBV-related HCC are rarely investigated. In this study, we found that the expression levels of miR-302c-3p were prominently down-regulated in HCC tissues compared to matched tumor-adjacent tissues. Moreover, miR-302c-3p under-expression was detected in HCC cell lines compared to a normal hepatic cell line LO2...
2018: Journal of Cancer
Haihua Peng, Chengtao Wang, Weiwei Xiao, Xiaodan Lin, Kaiyun You, Jun Dong, Zhenyu Wang, Xiaobi Yu, Zhifan Zeng, Tongchong Zhou, Yuanhong Gao, Bixiu Wen
To explore clinical characteristics which could be applied to predict pathologic complete response (pCR) for patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (neo-CRT) and total mesorectal excision (TME). 297 patients with locally advanced rectal cancer (cT3-4 or cN+) who were treated with neo-CRT followed by TME were retrospectively reviewed. Clinical characteristics including age, gender, tumor distance from anus, serum CEA, hemoglobin levels before treatment and clinical TN stage were used to investigate the association with pCR after neo-CRT...
2018: Journal of Cancer
Wen-Hui Su, Yuh-Shan Jou, Jia-Hao Zhang, Chun-Ming Ho, Dar-In Tai
Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer-related mortality because of its poor prognosis. Therefore, identifying targetable genetic mutations and mutational signatures associated with prognosis and treatment strategies are needed. Ultra-deep sequencing of 409 cancer genes using formalin-fixed paraffin-embedded tissue from 33 male patients with hepatitis B virus-associated HCC was performed to identify mutational signatures associated with the prognosis of HCC...
2018: Journal of Cancer
Chuanyi Zhang, Xinzhou Deng, Li Qiu, Feng Peng, Shanshan Geng, Li Shen, Zhiguo Luo
Radiotherapy has played a limited role for the treatment of human esophageal cancer owing to the risk of tumor radioresistance. Core 1 β1, 3-galactosyltransferase (C1GalT1), which catalyzes the formation of core 1 O-glycan structures, is frequently overexpressed during tumorigenesis. However, the exact effects and mechanisms of C1GalT1 in the radioresistance of esophageal cancer remain unclear. In this study, Public databases and our data revealed that C1GalT1 expression was up-regulated in esophageal cancer tissues and was associated with poor survival...
2018: Journal of Cancer
Shibao Li, Yao Zhao, Wenbai Chen, Lingyu Yin, Jie Zhu, Haoliang Zhang, Chenchen Cai, Pengpeng Li, Lingyan Huang, Ping Ma
Up-regulation of serum ephrinA2 is common in various malignancies and has been suggested as a potential biomarker for the diagnosis and prognosis of prostate cancer (PCa). However, the type of serum ephrinA2 expressed in PCa patients remains elusive. Furthermore, the level of exosomal ephrinA2 derived from serum is increased in patients with osteoporosis, a common complication of PCa patients undergoing androgen deprivation therapy. It is unknown whether exosomes derived from PCa patient serum contains ephrinA2...
2018: Journal of Cancer
Tao Song, Cong Wang, Cheng Guo, Qingguang Liu, Xin Zheng
As a pattern recognition receptor, pentraxin 3 (PTX3) has been found to exert the pleiotropic roles on a variety of cancers. However, the accurate clinical significance of PTX3 in hepatocellular carcinoma (HCC) has not been well defined. The aim of the present investigation was to determine the expression characteristics, prognostic significance, and the relevant biological effect of PTX3 in HCC. The expression of PTX3 was evaluated in tumor and adjacent liver tissues from 210 HCC patients using immunohistochemistry staining...
2018: Journal of Cancer
Tao Guo, Ping Wu, Pengpeng Liu, Baiyang Chen, Xiang Jiang, Yang Gu, Zhisu Liu, Zhen Li
Objective: We conducted a network meta-analysis to comprehensively compare various anticancer agents used in transarterial chemoembolization (TACE) based on the Bayesian theorem. Methods: Globally recognized electronic databases, including PubMed, EMBASE, and Cochrane Central, were searched to retrieve relevant randomized controlled trials (RCTs) comparing anticancer agents in TACE for hepatocellular carcinoma (HCC) patients. The therapeutic response, adverse events and overall survival rate were selected as parametric data to evaluate the clinical efficacy...
2018: Journal of Cancer
Li Sun, Yingying Su, Xiangxiang Liu, Mu Xu, Xiaoxiang Chen, Yefei Zhu, Zhirui Guo, Tingting Bai, Lin Dong, Chenchen Wei, Xiaoxiao Cai, Bangshun He, Yuqin Pan, Huiling Sun, Shukui Wang
Background: Hepatocellular carcinoma (HCC) is one of the most aggressive cancers, with limited new diagnostic and therapeutic measures. This study aimed to investigate the utility of specific serum and exosome lncRNAs as biomarkers for early diagnosis of HCC. Methods : The relative expression levels of eight selected lncRNAs in serum were evaluated by quantitative reverse transcription-PCR (qRT-PCR) in the training and validation sets of HCC patients and matched healthy controls. Additionally, the stability, specificity and diagnostic efficiency of these lncRNAs were evaluated to determine their potential as biomarkers...
2018: Journal of Cancer
Zhiyan Liu, Jing Wang, Zhiyong Yuan, Baozhong Zhang, Linlin Gong, Lujun Zhao, Ping Wang
To evaluate the clinical outcomes of simultaneous dose reduction of elective nodal area with intensity-modulated radiotherapy (SIR-IMRT) versus conventional IMRT (C-IMRT) in patients with limited-stage small-cell lung cancer (LS-SCLC), patients with LS-SCLC who received definitive SIR-IMRT or C-IMRT were retrospectively analyzed. In SIR-IMRT group, the prescribed dose was 60Gy to the planning gross target volume (PTVG ), and 54Gy to the planning target volume (PTV). In the C-IMRT group, the prescribed dose was 60Gy to the whole PTV...
2018: Journal of Cancer
Sai Han, Xuejiao Shi, Lu Liu, Liju Zong, Jingjing Zhang, Qian Chen, Qiuhong Qian, Li Chen, Ying Wang, Jing Jin, Yana Ma, Baoxia Cui, Xingsheng Yang, Youzhong Zhang
B7-H3, which has been reported to be a co-regulatory ligand of the B7 family, can suppress T cell-mediated immunity and has also been reported to be expressed in many malignancies. In this study, we found that B7-H3 was primarily expressed in the cytoplasm of cervical cancer cells and was associated with deep stromal invasion (P=0.0013). The disease-free survival data showed that cervical cancer patients whose tumours were positive for B7-H3 expression had higher mortality rates compared with patients whose tumours lacked B7-H3 expression (P=0...
2018: Journal of Cancer
Xiu-Xiu Hu, Xue-Ni Xu, Bang-Shun He, Hui-Ling Sun, Tao Xu, Xiang-Xiang Liu, Xiao-Xiang Chen, Kai-Xuan Zeng, Shu-Kui Wang, Yu-Qin Pan
Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research, we found that miR-485-5p was at lower level expression in CRC tissues and cell lines compared to the paired paracancerous tissues and the normal colon epithelial cell line FHC, correspondingly...
2018: Journal of Cancer
Harald Hessel, Manuela Poignée-Heger, Sabine Lohmann, Bianca Hirscher, Andrea Herold, Gerald Assmann, Jan Budczies, Karl Sotlar, Thomas Kirchner
Background: "Triple-negative breast cancers" (TNBC) comprise a heterogeneous group of about 15% of invasive BCs lacking the expression of estrogen and progesterone receptors (ER, PR) and the expression of HER2 (ERBB2) and are therefore no established candidates for targeted treatment options in BC, i.e., endocrine and anti-HER2 therapy. The aim of the present study was to use gene expression profiling and immunohistochemical (IHC) characterization to identify receptor tyrosine kinase (RTK) profiles that would allow patient stratification for the purposes of target-oriented personalized tumor therapy in TNBC...
2018: Journal of Cancer
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