journal
https://read.qxmd.com/read/38179214/adsc-exos-outperform-bmsc-exos-in-alleviating-hydrostatic-pressure-induced-injury-to-retinal-ganglion-cells-by-upregulating-nerve-growth-factors
#21
JOURNAL ARTICLE
Zhi-Kun Zheng, Lei Kong, Min Dai, Yi-Dan Chen, Yan-Hua Chen
BACKGROUND: Mesenchymal stem cells (MSCs) have protective effects on the cornea, lacrimal gland, retina, and photoreceptor cell damage, which may be mediated by exosomes (exos) released by MSCs. AIM: To investigate the ameliorating effect of exos derived from different MSCs on retinal ganglion cell (RGC) injury induced by hydrostatic pressure. METHODS: The RGC injury model was constructed by RGC damage under different hydrostatic pressures (40, 80, 120 mmHg)...
December 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/38179213/mid-term-outcomes-of-microfragmented-adipose-tissue-plus-arthroscopic-surgery-for-knee-osteoarthritis-a-randomized-active-control-multicenter-clinical-trial
#22
JOURNAL ARTICLE
Cong-Zi Wu, Zhen-Yu Shi, Zhen Wu, Wen-Jun Lin, Wei-Bo Chen, Xue-Wen Jia, Si-Cheng Xiang, Hui-Hui Xu, Qin-Wen Ge, Kai-Ao Zou, Xu Wang, Jia-Li Chen, Ping-Er Wang, Wen-Hua Yuan, Hong-Ting Jin, Pei-Jian Tong
BACKGROUND: Osteoarthritis (OA) is the most prevalent form of degenerative whole-joint disease. Before the final option of knee replacement, arthroscopic surgery was the most widely used joint-preserving surgical treatment. Emerging regenerative therapies, such as those involving platelet-rich plasma, mesenchymal stem cells, and microfragmented adipose tissue (MFAT), have been pushed to the forefront of treatment to prevent the progression of OA. Currently, MFAT has been successfully applied to treat different types of orthopedic diseases...
December 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/38058960/hypoxia-and-inflammatory-factor-preconditioning-enhances-the-immunosuppressive-properties-of-human-umbilical-cord-mesenchymal-stem-cells
#23
JOURNAL ARTICLE
Hang Li, Xiao-Qing Ji, Shu-Ming Zhang, Ri-Hui Bi
BACKGROUND: Mesenchymal stem cells (MSCs) have great potential for the treatment of various immune diseases due to their unique immunomodulatory properties. However, MSCs exposed to the harsh inflammatory environment of damaged tissue after intravenous transplantation cannot exert their biological effects, and therefore, their therapeutic efficacy is reduced. In this challenging context, an in vitro preconditioning method is necessary for the development of MSC-based therapies with increased immunomodulatory capacity and transplantation efficacy...
November 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/38058959/dissecting-molecular-mechanisms-underlying-ferroptosis-in-human-umbilical-cord-mesenchymal-stem-cells-role-of-cystathionine-%C3%AE-lyase-hydrogen-sulfide-pathway
#24
JOURNAL ARTICLE
Bin Hu, Xiang-Xi Zhang, Tao Zhang, Wan-Cheng Yu
BACKGROUND: Ferroptosis can induce low retention and engraftment after mesenchymal stem cell (MSC) delivery, which is considered a major challenge to the effectiveness of MSC-based pulmonary arterial hypertension (PAH) therapy. Interestingly, the cystathionine γ-lyase (CSE)/hydrogen sulfide (H2 S) pathway may contribute to mediating ferroptosis. However, the influence of the CSE/H2 S pathway on ferroptosis in human umbilical cord MSCs (HUCMSCs) remains unclear. AIM: To clarify whether the effect of HUCMSCs on vascular remodelling in PAH mice is affected by CSE/H2 S pathway-mediated ferroptosis, and to investigate the functions of the CSE/H2 S pathway in ferroptosis in HUCMSCs and the underlying mechanisms...
November 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/38058958/how-to-enhance-the-ability-of-mesenchymal-stem-cells-to-alleviate-intervertebral-disc-degeneration
#25
REVIEW
Qing-Xiang Zhang, Min Cui
Intervertebral disc (ID) degeneration (IDD) is one of the main causes of chronic low back pain, and degenerative lesions are usually caused by an imbalance between catabolic and anabolic processes in the ID. The environment in which the ID is located is harsh, with almost no vascular distribution within the disc, and the nutrient supply relies mainly on the diffusion of oxygen and nutrients from the blood vessels located under the endplate. The stability of its internal environment also plays an important role in preventing IDD...
November 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37970238/potential-of-dental-pulp-stem-cells-and-their-products-in-promoting-peripheral-nerve-regeneration-and-their-future-applications
#26
REVIEW
Wen-Bo Xing, Shu-Ting Wu, Xin-Xin Wang, Fen-Yao Li, Ruo-Xuan Wang, Ji-Hui He, Jiao Fu, Yan He
Peripheral nerve injury (PNI) seriously affects people's quality of life. Stem cell therapy is considered a promising new option for the clinical treatment of PNI. Dental stem cells, particularly dental pulp stem cells (DPSCs), are adult pluripotent stem cells derived from the neuroectoderm. DPSCs have significant potential in the field of neural tissue engineering due to their numerous advantages, such as easy isolation, multidifferentiation potential, low immunogenicity, and low transplant rejection rate...
October 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37970237/microrna-584-5p-runx-family-transcription-factor-2-axis-mediates-hypoxia-induced-osteogenic-differentiation-of-periosteal-stem-cells
#27
JOURNAL ARTICLE
Jia-Jia Lu, Xiao-Jian Shi, Qiang Fu, Yong-Chuan Li, Lei Zhu, Nan Lu
BACKGROUND: The hypoxic environment during bone healing is important in regulating the differentiation of periosteal stem cells (PSCs) into osteoblasts or chondrocytes; however, the underlying mechanisms remain unclear. AIM: To determine the effect of hypoxia on PSCs, and the expression of microRNA-584-5p (miR-584-5p) and RUNX family transcription factor 2 (RUNX2) in PSCs was modulated to explore the impact of the miR-584-5p/RUNX2 axis on hypoxia-induced osteogenic differentiation of PSCs...
October 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37900941/enhanced-wound-healing-and-hemostasis-with-exosome-loaded-gelatin-sponges-from-human-umbilical-cord-mesenchymal-stem-cells
#28
JOURNAL ARTICLE
Xin-Mei Hu, Can-Can Wang, Yu Xiao, Peng Jiang, Yu Liu, Zhong-Quan Qi
BACKGROUND: Rapid wound healing remains a pressing clinical challenge, necessitating studies to hasten this process. A promising approach involves the utilization of human umbilical cord mesenchymal stem cells (hUC-MSCs) derived exosomes. The hypothesis of this study was that these exosomes, when loaded onto a gelatin sponge, a common hemostatic material, would enhance hemostasis and accelerate wound healing. AIM: To investigate the hemostatic and wound healing efficacy of gelatin sponges loaded with hUC-MSCs-derived exosomes...
September 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37900940/multiomics-reveal-human-umbilical-cord-mesenchymal-stem-cells-improving-acute-lung-injury-via-the-lung-gut-axis
#29
JOURNAL ARTICLE
Lu Lv, En-Hai Cui, Bin Wang, Li-Qin Li, Feng Hua, Hua-Dong Lu, Na Chen, Wen-Yan Chen
BACKGROUND: Acute lung injury (ALI) and its final severe stage, acute respiratory distress syndrome, are associated with high morbidity and mortality rates in patients due to the lack of effective specific treatments. Gut microbiota homeostasis, including that in ALI, is important for human health. Evidence suggests that the gut microbiota improves lung injury through the lung-gut axis. Human umbilical cord mesenchymal cells (HUC-MSCs) have attractive prospects for ALI treatment. This study hypothesized that HUC-MSCs improve ALI via the lung-gut microflora...
September 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37900939/mechanism-of-adipose-derived-mesenchymal-stem-cell-exosomes-in-the-treatment-of-heart-failure
#30
JOURNAL ARTICLE
Lei Wang, Jin-Jin Zhang, Sha-Sha Wang, Liang Li
BACKGROUND: Heart failure (HF) is a global health problem characterized by impaired heart function. Cardiac remodeling and cell death contribute to the development of HF. Although treatments such as digoxin and angiotensin receptor blocker drugs have been used, their effectiveness in reducing mortality is uncertain. Researchers are exploring the use of adipose-derived mesenchymal stem cell (ADMSC) exosomes (Exos) as a potential therapy for HF. These vesicles, secreted by cells, may aid in tissue repair and regulation of inflammation and immune responses...
September 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37900938/integrin-beta-3-overexpressing-mesenchymal-stromal-cells-display-enhanced-homing-and-can-reduce-atherosclerotic-plaque
#31
JOURNAL ARTICLE
Hai-Juan Hu, Xue-Ru Xiao, Tong Li, De-Min Liu, Xue Geng, Mei Han, Wei Cui
BACKGROUND: Umbilical cord (UC) mesenchymal stem cell (MSC) transplantation is a potential therapeutic intervention for atherosclerotic vascular disease. Integrin beta 3 (ITGB3) promotes cell migration in several cell types. However, whether ITGB-modified MSCs can migrate to plaque sites in vivo and play an anti-atherosclerotic role remains unclear. AIM: To investigate whether ITGB3-overexpressing MSCs (MSCsITGB3 ) would exhibit improved homing efficacy in atherosclerosis...
September 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37900937/interferon-%C3%AE-priming-enhances-the-therapeutic-effects-of-menstrual-blood-derived-stromal-cells-in-a-mouse-liver-ischemia-reperfusion-model
#32
JOURNAL ARTICLE
Qi Zhang, Si-Ning Zhou, Jia-Min Fu, Li-Jun Chen, Yang-Xin Fang, Zhen-Yu Xu, Hui-Kang Xu, Yin Yuan, Yu-Qi Huang, Ning Zhang, Yi-Fei Li, Charlie Xiang
BACKGROUND: Mesenchymal stem cells (MSCs) have been used in liver transplantation and have certain effects in alleviating liver ischemia-reperfusion injury (IRI) and regulating immune rejection. However, some studies have indicated that the effects of MSCs are not very significant. Therefore, approaches that enable MSCs to exert significant and stable therapeutic effects are worth further study. AIM: To enhance the therapeutic potential of human menstrual blood-derived stromal cells (MenSCs) in the mouse liver ischemia-reperfusion (I/R) model via interferon-γ (IFN-γ) priming...
September 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37700823/interferon-gamma-and-tumor-necrosis-factor-alpha-synergistically-enhance-the-immunosuppressive-capacity-of-human-umbilical-cord-derived-mesenchymal-stem-cells-by-increasing-pd-l1-expression
#33
JOURNAL ARTICLE
Zhuo Chen, Meng-Wei Yao, Zhi-Lin Shen, Shi-Dan Li, Wei Xing, Wei Guo, Zhan Li, Xiao-Feng Wu, Luo-Quan Ao, Wen-Yong Lu, Qi-Zhou Lian, Xiang Xu, Xiang Ao
BACKGROUND: The immunosuppressive capacity of mesenchymal stem cells (MSCs) is dependent on the "license" of several proinflammatory factors to express immunosuppressive factors such as programmed cell death 1 ligand 1 (PD-L1), which determines the clinical therapeutic efficacy of MSCs for inflammatory or immune diseases. In MSCs, interferon-gamma (IFN-γ) is a key inducer of PD-L1 expression, which is synergistically enhanced by tumor necrosis factor-alpha (TNF-α); however, the underlying mechanism is unclear...
August 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37700822/constitutive-aryl-hydrocarbon-receptor-facilitates-the-regenerative-potential-of-mouse-bone-marrow-mesenchymal-stromal-cells
#34
JOURNAL ARTICLE
Jing Huang, Yi-Ning Wang, Yi Zhou
BACKGROUND: Bone marrow mesenchymal stromal cells (BMSCs) are the commonly used seed cells in tissue engineering. Aryl hydrocarbon receptor (AhR) is a transcription factor involved in various cellular processes. However, the function of constitutive AhR in BMSCs remains unclear. AIM: To investigate the role of AhR in the osteogenic and macrophage-modulating potential of mouse BMSCs (mBMSCs) and the underlying mechanism. METHODS: Immunochemistry and immunofluorescent staining were used to observe the expression of AhR in mouse bone marrow tissue and mBMSCs...
August 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37700821/up-to-date-meta-analysis-of-long-term-evaluations-of-mesenchymal-stem-cell-therapy-for-complex-perianal-fistula
#35
JOURNAL ARTICLE
Fang Cheng, Huang Zhong, Zhong Huang, Zhi Li
BACKGROUND: Local mesenchymal stem cell (MSC) therapy for complex perianal fistulas (PFs) has shown considerable promise. But, the long-term safety and efficacy of MSC therapy in complex PFs remain unknown. AIM: To explore the long-term effectiveness and safety of local MSC therapy for complex PFs. METHODS: Sources included the PubMed, EMBASE, and Cochrane Library databases. A standard meta-analysis was performed using RevMan 5.3. RESULTS: After screening, 6 studies met the inclusion criteria...
August 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37700820/mastering-the-craft-creating-an-insightful-and-widely-cited-literature-review
#36
EDITORIAL
Shengwen Calvin Li
The art of constructing an insightful literature review manuscript has witnessed an exemplar in the work of Oz et al (2023), wherein concept progression harmoniously merges with figures and tables. Reflecting on retrospective data science, it is evident that well-cited articles can wield a transformative influence on the Journal Citation Reports Impact Factor score, as exemplified by Robert Weinberg's landmark on cancer (Hanahan and Weinberg, 2011). Here, we aim to spotlight a commendable contribution by Tuba Oz, Ajeet Kaushik, and Małgorzata Kujawska in this issue while pivoting towards identifying the hallmarks of a subpar literature review-elements that hinder rather than promote advancement...
August 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37700819/wnt-signaling-pathway-inhibitor-promotes-mesenchymal-stem-cells-differentiation-into-cardiac-progenitor-cells-in-vitro-and-improves-cardiomyopathy-in-vivo
#37
JOURNAL ARTICLE
Rabbia Muneer, Rida-E-Maria Qazi, Abiha Fatima, Waqas Ahmad, Asmat Salim, Luciana Dini, Irfan Khan
BACKGROUND: Cardiovascular diseases particularly myocardial infarction (MI) are the leading cause of mortality and morbidity around the globe. As cardiac tissue possesses very limited regeneration potential, therefore use of a potent small molecule, inhibitor Wnt production-4 (IWP-4) for stem cell differentiation into cardiomyocytes could be a promising approach for cardiac regeneration. Wnt pathway inhibitors may help stem cells in their fate determination towards cardiomyogenic lineage and provide better homing and survival of cells in vivo ...
August 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37700818/quercetin-ameliorates-oxidative-stress-induced-senescence-in-rat-nucleus-pulposus-derived-mesenchymal-stem-cells-via-the-mir-34a-5p-sirt1-axis
#38
JOURNAL ARTICLE
Wen-Jie Zhao, Xin Liu, Man Hu, Yu Zhang, Peng-Zhi Shi, Jun-Wu Wang, Xu-Hua Lu, Xiao-Fei Cheng, Yu-Ping Tao, Xin-Min Feng, Yong-Xiang Wang, Liang Zhang
BACKGROUND: Intervertebral disc degeneration (IDD) is a main contributor to low back pain. Oxidative stress, which is highly associated with the progression of IDD, increases senescence of nucleus pulposus-derived mesenchymal stem cells (NPMSCs) and weakens the differentiation ability of NPMSCs in degenerated intervertebral discs (IVDs). Quercetin (Que) has been demonstrated to reduce oxidative stress in diverse degenerative diseases. AIM: To investigate the role of Que in oxidative stress-induced NPMSC damage and to elucidate the underlying mechanism...
August 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37545758/transplantation-of-human-induced-pluripotent-stem-cell-derived-keratinocytes-accelerates-deep-second-degree-burn-wound-healing
#39
JOURNAL ARTICLE
Li-Jun Wu, Wei Lin, Jian-Jiang Liu, Wei-Xin Chen, Wen-Jun He, Yuan Shi, Xiao Liu, Ke Li
BACKGROUND: Current evidence shows that human induced pluripotent stem cells (hiPSCs) can effectively differentiate into keratinocytes (KCs), but its effect on skin burn healing has not been reported. AIM: To observe the effects of hiPSCs-derived KCs transplantation on skin burn healing in mice and to preliminarily reveal the underlying mechanisms. METHODS: An analysis of differentially expressed genes in burn wounds based on GEO datasets GSE140926, and GSE27186 was established...
July 26, 2023: World Journal of Stem Cells
https://read.qxmd.com/read/37545757/neural-stem-cells-for-parkinson-s-disease-management-challenges-nanobased-support-and-prospects
#40
REVIEW
Tuba Oz, Ajeet Kaushik, Małgorzata Kujawska
Parkinson's disease (PD), characterized by loss of nigrostriatal dopaminergic neurons, is one of the most predominant neurodegenerative diseases affecting the elderly population worldwide. The concept of stem cell therapy in managing neurodegenerative diseases has evolved over the years and has recently rapidly progressed. Neural stem cells (NSCs) have a few key features, including self-renewal, proliferation, and multipotency, which make them a promising agent targeting neurodegeneration. It is generally agreed that challenges for NSC-based therapy are present at every stage of the transplantation process, including preoperative cell preparation and quality control, perioperative procedures, and postoperative graft preservation, adherence, and overall therapy success...
July 26, 2023: World Journal of Stem Cells
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