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Stem Cells International

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https://www.readbyqxmd.com/read/30018644/in-vitro-uptake-of-hydroxyapatite-nanoparticles-and-their-effect-on-osteogenic-differentiation-of-human-mesenchymal-stem-cells
#1
Xing Yang, Yuanyuan Li, Xujie Liu, Ranran Zhang, Qingling Feng
There have been many applications in biomedical fields based on hydroxyapatite nanoparticles (HA NPs) over the past decades. However, the biocompatibility of HANPs is affected by exposure dose, particle size, and the way of contact with cells. The objective of this study is to investigate the effect of HA NPs with different sizes on osteogenesis using human mesenchymal stem cells (hMSCs). Three different-sized HA NPs (~50, ~100, and ~150 nm, resp.) were synthesized to study the cytotoxicity, cellular uptake, and effect on osteogenic differentiation of hMSCs...
2018: Stem Cells International
https://www.readbyqxmd.com/read/30013601/user-friendly-genetic-conditional-knockout-strategies-by-crispr-cas9
#2
Liangliang Chen, Ying Ye, Hongxia Dai, Heyao Zhang, Xue Zhang, Qiang Wu, Zhexin Zhu, Rapolas Spalinskas, Wenyan Ren, Wensheng Zhang
Loss-of-function studies are critically important in gene functional analysis of model organisms and cells. However, conditional gene inactivation in diploid cells is difficult to achieve, as it involves laborious vector construction, multifold electroporation, and complicated genotyping. Here, a strategy is presented for generating biallelic conditional gene and DNA regulatory region knockouts in mouse embryonic stem cells by codelivery of CRISPR-Cas9 and short-homology-arm targeting vectors sequentially or simultaneously...
2018: Stem Cells International
https://www.readbyqxmd.com/read/30013600/mesenchymal-stem-cell-based-immunomodulation-properties-and-clinical-application
#3
REVIEW
Mengyuan Wang, Quan Yuan, Liang Xie
Mesenchymal stem cells (MSCs) are multipotent stem cells characterized by self-renewal, production of clonal cell populations, and multilineage differentiation. They exist in nearly all tissues and play a significant role in tissue repair and regeneration. Additionally, MSCs possess wide immunoregulatory properties via interaction with immune cells in both innate and adaptive immune systems, leading to immunosuppression of various effector functions. Numerous bioactive molecules secreted by MSCs, particularly cytokines, growth factors, and chemokines, exert autocrine/paracrine effects that modulate the physiological processes of MSCs...
2018: Stem Cells International
https://www.readbyqxmd.com/read/30008753/therapeutic-use-of-extraembryonic-derived-tissues
#4
EDITORIAL
Michael Uhlin, Mohamed Abumaree, Essam M Abdelalim
No abstract text is available yet for this article.
2018: Stem Cells International
https://www.readbyqxmd.com/read/30008752/generation-of-retinal-organoids-with-mature-rods-and-cones-from-urine-derived-human-induced-pluripotent-stem-cells
#5
Guilan Li, Bingbing Xie, Liwen He, Tiancheng Zhou, Guanjie Gao, Shengxu Liu, Guangjin Pan, Jian Ge, Fuhua Peng, Xiufeng Zhong
Urine cells, a body trash, have been successfully reprogrammed into human induced pluripotent stem cells (U-hiPSCs) which hold a huge promise in regenerative medicine. However, it is unknown whether or to what extent U-hiPSCs can generate retinal cells so far. With a modified retinal differentiation protocol without addition of retinoic acid (RA), our study revealed that U-hiPSCs were able to differentiate towards retinal fates and form 3D retinal organoids containing laminated neural retina with all retinal cell types located in proper layer as in vivo...
2018: Stem Cells International
https://www.readbyqxmd.com/read/30008751/use-of-self-assembling-peptides-to-enhance-stem-cell-function-for-therapeutic-angiogenesis
#6
Hyung Sub Park, Geum Hee Choi, Daehwan Kim, Tae Woo Jung, In Mok Jung, Jung Kee Chung, Taeseung Lee
The use of nanomaterials for biomedical applications has become a promising field in regenerative medicine. Self-assembling peptides (SAPs) have been proposed as a good candidate because they are able to self-assemble into stable hydrogels and interact with cells or molecules when combined together. This in turn can lead to the improved survival or action of cells or molecules to obtain the desired effects. In this study, we investigated whether the combination of mesenchymal stem cells (MSCs) with SAPs could improve angiogenesis in ischemic hindlimbs of rats compared to MSC or SAP treatment alone...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29983715/shp2-mediated-signal-networks-in-stem-cell-homeostasis-and-dysfunction
#7
REVIEW
Chen Kan, Fan Yang, Siying Wang
Stem cells, including embryonic stem cells (ESCs) and adult stem cells, play a central role in mammal organism development and homeostasis. They have two unique properties: the capacity for self-renewal and the ability to differentiate into many specialized cell types. Src homology region 2- (SH2-) containing protein tyrosine phosphatase 2 (SHP-2), a nonreceptor protein tyrosine phosphatase encoded by protein tyrosine phosphatase nonreceptor type 11 gene (PTPN11), regulates multicellular differentiation, proliferation, and survival through numerous conserved signal pathways...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29983714/location-isolation-and-identification-of-mesenchymal-stem-cells-from-adult-human-sweat-glands
#8
Yingzhi Ma, Meirong Li, Jinyu Liu, Chuanchao Pang, Jianqing Zhang, Yulin Li, Xiaobing Fu
Sweat glands (SGs) are spread over almost the entire surface of the human body and are essential for thermoregulation. Theoretically, tissue-specific stem cells (TSSCs) are excellent candidate cells for the regeneration of SGs due to their genetic stability and differentiation ability. Herein, we attempted to isolate TSSCs derived from adult human sweat glands (ahSGs). ahSGs were localized and identified by H&E staining, double immunofluorescence staining, transmission electron microscope (TEM), and immuno-TEM...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29977309/extracellular-vesicles-a-new-prospective-in-crosstalk-between-microenvironment-and-stem-cells-in-hematological-malignancies
#9
REVIEW
Ilaria Laurenzana, Daniela Lamorte, Stefania Trino, Luciana De Luca, Concetta Ambrosino, Pietro Zoppoli, Vitalba Ruggieri, Luigi Del Vecchio, Pellegrino Musto, Antonella Caivano, Geppino Falco
The bone marrow (BM) microenvironment in hematological malignancies (HMs) comprises heterogeneous populations of neoplastic and nonneoplastic cells. Cancer stem cells (CSCs), neoplastic cells, hematopoietic stem cells (HSCs), and mesenchymal stromal/stem cells (MSCs) are all components of this microenvironment. CSCs are the HM initiators and are associated with neoplastic growth and drug resistance, while HSCs are able to reconstitute the entire hematopoietic system; finally, MSCs actively support hematopoiesis...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29977308/autologous-stem-cell-therapy-in-critical-limb-ischemia-a-meta-analysis-of-randomized-controlled-trials
#10
REVIEW
Baocheng Xie, Houlong Luo, Yusheng Zhang, Qinghui Wang, Chenhui Zhou, Daohua Xu
Objective: Critical limb ischemia (CLI) is the most dangerous stage of peripheral artery disease (PAD). Many basic researches and clinical treatment had been focused on stem cell transplantation for CLI. This systematic review was performed to review evidence for safety and efficacy of autologous stem cell therapy in CLI. Methods: A systematic literature search was performed in the SinoMed, PubMed, Embase, ClinicalTrials.gov, and Cochrane Controlled Trials Register databases from building database to January 2018...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29977307/evaluation-of-oxidative-stress-and-mitophagy-during-adipogenic-differentiation-of-adipose-derived-stem-cells-isolated-from-equine-metabolic-syndrome-ems-horses
#11
Krzysztof Marycz, Christine Weiss, Agnieszka Śmieszek, Katarzyna Kornicka
Mesenchymal stem cells (MSCs) are frequently used in both human and veterinary medicine because their unique properties, such as modulating the immune response and differentiating into multiple lineages, make them a valuable tool in cell-based therapies. However, many studies have indicated the age-, lifestyle-, and disease-related deterioration of MSC regenerative characteristics. However, it still needs to be elucidated how the patient's health status affects the effectiveness of MSC differentiation. In the present study, we isolated mesenchymal stem cells from adipose tissue (adipose-derived mesenchymal stem cells (ASCs)) from horses diagnosed with equine metabolic syndrome (EMS), a common metabolic disorder characterized by pathological obesity and insulin resistance...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29977306/isolation-and-characterization-of-multipotent-turkey-tendon-derived-stem-cells
#12
Qian Liu, Yaxi Zhu, Peter C Amadio, Steven L Moran, Anne Gingery, Chunfeng Zhao
Tendon injuries are among the most common and severe hand injuries with a high demand for functional recovery. Stem cells have been identified and isolated from different species and a variety of tissues for the sake of regenerative medicine. Recently, turkey has been suggested as a potential new large animal model for flexor tendon-related research. However, turkey tissue-specific stem cells have not been investigated. Here, we presented the isolation and verification of tendon-derived stem cells (TDSCs) from 6- to 8-month-old heritage-breed turkey...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29977305/xenogenic-implantation-of-equine-synovial-fluid-derived-mesenchymal-stem-cells-leads-to-articular-cartilage-regeneration
#13
Mohammed Zayed, Steven Newby, Nabil Misk, Robert Donnell, Madhu Dhar
Horses are widely used as large animal preclinical models for cartilage repair studies, and hence, there is an interest in using equine synovial fluid-derived mesenchymal stem cells (SFMSCs) in research and clinical applications. Since, we have previously reported that similar to bone marrow-derived MSCs (BMMSCs), SFMSCs may also exhibit donor-to-donor variations in their stem cell properties; the current study was carried out as a proof-of-concept study, to compare the in vivo potential of equine BMMSCs and SFMSCs in articular cartilage repair...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29971111/noncoding-rnas-and-stem-cell-function-and-therapy
#14
EDITORIAL
Yaoliang Tang, Wei Lei, Yanfang Chen, Xiaolong Wang, Mark W Hamrick, Mi Zhou
No abstract text is available yet for this article.
2018: Stem Cells International
https://www.readbyqxmd.com/read/29971110/the-efficacy-of-graphene-foams-for-culturing-mesenchymal-stem-cells-and-their-differentiation-into-dopaminergic-neurons
#15
Nishat Tasnim, Vikram Thakur, Munmun Chattopadhyay, Binata Joddar
The implantation of stem cells in vivo is the ideal approach for the restoration of normal life functions, such as replenishing the decreasing levels of affected dopaminergic (DA) neurons during neurodegenerative disease conditions. However, combining stem cells with biomaterial scaffolds provides a promising strategy for engineering tissues or cellular delivery for directed stem cell differentiation as a means of replacing diseased/damaged tissues. In this study, mouse mesenchymal stem cells (MSCs) were differentiated into DA neurons using sonic hedgehog, fibroblast growth factor, basic fibroblast growth factor, and brain-derived neurotrophic factor, while they were cultured within collagen-coated 3D graphene foams (GF)...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29955232/marrow-adipose-tissue-its-origin-function-and-regulation-in-bone-remodeling-and-regeneration
#16
REVIEW
Qiwen Li, Yunshu Wu, Ning Kang
Marrow adipose tissue (MAT) is a unique fat depot in the bone marrow and exhibits close relationship with hematopoiesis and bone homeostasis. MAT is distinct from peripheral adipose tissue in respect of its heterogeneous origin, site-specific distribution, and complex and perplexing function. Though MAT is indicated to function in hematopoiesis, skeletal remodeling, and energy metabolism, its explicit characterization still requires further research. In this review, we highlight recent advancement made in MAT regarding the origin and distribution of MAT, the local interaction with bone homeostasis and hematopoietic niche, the systemic endocrine regulation of metabolism, and MAT-based strategies to enhance bone formation...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29951100/efficiency-of-cell-therapy-to-gc-induced-onfh-bmscs-with-dkk-1-interference-is-not-superior-to-unmodified-bmscs
#17
Wei Zhun, Li Donghai, Yang Zhouyuan, Zhao Haiyan, Kang Pengde
Glucocorticoid-induced osteonecrosis of the femoral head (ONFH) is a hip disorder, and it threatens patients who require megadose of steroid therapies. Nowadays, no valid therapies can reverse the development of GC-induced ONFH once it occurs. Stem cell therapy to GC-induced ONFH would be a promising choice. Although the pathogenesis of GC-induced ONFH is not yet fully clear, Dickkopf-1 (Dkk-1) upregulated by excessive GC use, which hinders the canonical Wnt pathway, could be an explanation. Thus, the aim of the present work lies in investigating the efficiency of the allograft bone marrow stem cells (BMSCs) with Dkk-1 interference in preventing the progression of the GC-induced ONFH...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29887893/mesenchymal-stromal-cells-and-cutaneous-wound-healing-a-comprehensive-review-of-the-background-role-and-therapeutic-potential
#18
REVIEW
Michael S Hu, Mimi R Borrelli, H Peter Lorenz, Michael T Longaker, Derrick C Wan
Cutaneous wound repair is a highly coordinated cascade of cellular responses to injury which restores the epidermal integrity and its barrier functions. Even under optimal healing conditions, normal wound repair of adult human skin is imperfect and delayed healing and scarring are frequent occurrences. Dysregulated wound healing is a major concern for global healthcare, and, given the rise in diabetic and aging populations, this medicoeconomic disease burden will continue to rise. Therapies to reliably improve nonhealing wounds and reduce scarring are currently unavailable...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29861746/mathematical-modeling-reveals-the-role-of-hypoxia-in-the-promotion-of-human-mesenchymal-stem-cell-long-term-expansion
#19
Shuhua Gao, Cheng Xiang, Kairong Qin, Changkai Sun
Many experimental studies have found that human mesenchymal stem cells (MSCs) in long-term culture exhibited enhanced cell proliferation and prolonged lifespan under hypoxia (around 1%-7% oxygen) against the normoxic condition (about 21% oxygen). Inspired by the experimental findings, we aimed to investigate the hypoxic effects on MSC expansion quantitatively through mathematical modeling to elucidate the corresponding biological mechanism. A two-compartment model based on ordinary differential equations (ODEs), which incorporate cellular division and senescence via state transition, was developed to describe the MSC expansion process...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29861745/direct-control-of-stem-cell-behavior-using-biomaterials-and-genetic-factors
#20
REVIEW
Jeong-Kee Yoon, Mi-Lan Kang, Joo Hyun Park, Kyoung-Mi Lee, Young Min Shin, Jin Woo Lee, Hyun Ok Kim, Hak-Joon Sung
Stem cells have recently emerged as an important candidate for cell therapy. However, some major limitations still exist such as a small quantity of cell supply, senescence, and insufficient differentiation efficiency. Therefore, there is an unmet need to control stem cell behavior for better clinical performance. Since native microenvironment factors including stem cell niche, genetic factors, and growth factors direct stem cell fate cooperatively, user-specified in vitro settings are required to understand the regulatory roles and effects of each factor, thereby applying the factors for improved cell therapy...
2018: Stem Cells International
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