journal
MENU ▼
Read by QxMD icon Read
search

Stem Cells International

journal
https://www.readbyqxmd.com/read/28326106/in-vivo-assessment-of-stem-cells-for-treating-neurodegenerative-disease-current-approaches-and-future-prospects
#1
REVIEW
Byeong-Wook Song
In recent years, stem cell-related therapies have been widely applied for treating neurodegenerative disease. Despite their potential, stem cell tracking and imaging techniques for the evaluation of in vivo proof-of-concept (PoC) therapies have not been sufficiently represented in the research area. This review summarizes the recent approaches that have been used for tracking and imaging engrafted stem cells in vivo. Furthermore, we introduce tissue clearing technology that can be applied to develop three-dimensional in vivo experiments...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28326105/paracrine-effects-of-bone-marrow-mononuclear-cells-in-survival-and-cytokine-expression-after-90-partial-hepatectomy
#2
Carlos Oscar Kieling, Carolina Uribe-Cruz, Mónica Luján López, Alessandro Bersch Osvaldt, Themis Reverbel da Silveira, Ursula Matte
Acute liver failure is a complex and fatal disease. Cell-based therapies are a promising alternative therapeutic approach for liver failure due to relatively simple technique and lower cost. The use of semipermeable microcapsules has become an interesting tool for evaluating paracrine effects in vivo. In this study, we aimed to assess the paracrine effects of bone marrow mononuclear cells (BMMC) encapsulated in sodium alginate to treat acute liver failure in an animal model of 90% partial hepatectomy (90% PH)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28321259/evaluation-of-three-devices-for-the-isolation-of-the-stromal-vascular-fraction-from-adipose-tissue-and-for-asc-culture-a-comparative-study
#3
Jonathan Rodriguez, Anne-Sophie Pratta, Nacira Abbassi, Hugo Fabre, Fanny Rodriguez, Cyrille Debard, Jacqueline Adobati, Fabien Boucher, Frédéric Mallein-Gerin, Céline Auxenfans, Odile Damour, Ali Mojallal
Adipose-derived stem/stromal cells (ASCs) reside in the stromal vascular fraction (SVF) of adipose tissue (AT) and can be easily isolated. However, extraction of the SVF from lipoaspirate is a critical step in generating ASC, and semiautomated devices have been developed to enhance the efficacy and reproducibility of the outcomes and to decrease manipulation and contamination. In this study, we compared the reference method used in our lab for SVF isolation from lipoaspirate, with three medical devices: GID SVF-1™, Puregraft™, and Stem...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28316629/periodontal-ligament-stem-cells-in-the-periodontitis-microenvironment-are-sensitive-to-static-mechanical-strain
#4
Jia Liu, Qiang Li, Shiyu Liu, Jie Gao, Wen Qin, Yang Song, Zuolin Jin
During orthodontic treatment, periodontium remodeling of periodontitis patients under mechanical force was abnormal. We have previously confirmed the function impairment of periodontal ligament stem cells (PDLSCs) in the periodontitis microenvironment which might be involved in this pathological process. However, the response of PDLSCs in periodontitis microenvironment to mechanical force remains unclear. Therefore, in the present study, we introduced a Flexcell tension apparatus and investigated the response of PDLSCs obtained from periodontal tissues of periodontitis patients (PPDLSCs) and of those obtained from healthy periodontal tissues (HPDLSCs) to different magnitudes of static mechanical strain (SMS)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28303154/mesenchymal-stem-cell-administration-in-patients-with-chronic-obstructive-pulmonary-disease-state-of-the-science
#5
REVIEW
Shih-Lung Cheng, Ching-Hsiung Lin, Chao-Ling Yao
Patients with chronic obstructive pulmonary disease (COPD) have chronic, irreversible airway inflammation; currently, there is no effective or curative treatment and the main goals of COPD management are to mitigate symptoms and improve patients' quality of life. Stem cell based therapy offers a promising therapeutic approach that has shown potential in diverse degenerative lung diseases. Preclinical studies have demonstrated encouraging outcomes of mesenchymal stem/stromal cells (MSCs) therapy for lung disorders including emphysema, bronchopulmonary dysplasia, fibrosis, and acute respiratory distress syndrome...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28303153/de-novo-human-cardiac-myocytes-for-medical-research-promises-and-challenges
#6
REVIEW
Veronique Hamel, Kang Cheng, Shudan Liao, Aizhu Lu, Yong Zheng, Yawen Chen, Yucai Xie, Wenbin Liang
The advent of cellular reprogramming technology has revolutionized biomedical research. De novo human cardiac myocytes can now be obtained from direct reprogramming of somatic cells (such as fibroblasts), from induced pluripotent stem cells (iPSCs, which are reprogrammed from somatic cells), and from human embryonic stem cells (hESCs). Such de novo human cardiac myocytes hold great promise for in vitro disease modeling and drug screening and in vivo cell therapy of heart disease. Here, we review the technique advancements for generating de novo human cardiac myocytes...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28303152/promising-therapeutic-strategies-for-mesenchymal-stem-cell-based-cardiovascular-regeneration-from-cell-priming-to-tissue-engineering
#7
REVIEW
Seung Taek Ji, Hyunyun Kim, Jisoo Yun, Joo Seop Chung, Sang-Mo Kwon
The primary cause of death among chronic diseases worldwide is ischemic cardiovascular diseases, such as stroke and myocardial infarction. Recent evidence indicates that adult stem cell therapies involving cardiovascular regeneration represent promising strategies to treat cardiovascular diseases. Owing to their immunomodulatory properties and vascular repair capabilities, mesenchymal stem cells (MSCs) are strong candidate therapeutic stem cells for use in cardiovascular regeneration. However, major limitations must be overcome, including their very low survival rate in ischemic lesion...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28298931/the-roles-of-insulin-like-growth-factors-in-mesenchymal-stem-cell-niche
#8
REVIEW
Amer Youssef, Doaa Aboalola, Victor K M Han
Many tissues contain adult mesenchymal stem cells (MSCs), which may be used in tissue regeneration therapies. However, the MSC availability in most tissues is limited which demands expansion in vitro following isolation. Like many developing cells, the state of MSCs is affected by the surrounding microenvironment, and mimicking this natural microenvironment that supports multipotent or differentiated state in vivo is essential to understand for the successful use of MSC in regenerative therapies. Many researchers are, therefore, optimizing cell culture conditions in vitro by altering growth factors, extracellular matrices, chemicals, oxygen tension, and surrounding pH to enhance stem cells self-renewal or differentiation...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28298930/predicting-the-remaining-lifespan-and-cultivation-related-loss-of-osteogenic-capacity-of-bone-marrow-multipotential-stromal-cells-applicable-across-a-broad-donor-age-range
#9
Sarah M Churchman, Sally A Boxall, Dennis McGonagle, Elena A Jones
Background and Objectives. Culture expanded multipotential stromal cells (MSCs) have considerable potential for bone regeneration therapy but their wider use is constrained by the lack of simple and predictive assays of functional potency. Extended passaging leads to loss of multipotency but speed of decline depends on MSC donor age. The aim of this study was to develop an assay predictive of MSC culture longevity applicable to a broad donor age range. Materials and Methods. Bone marrow (BM, n = 7) was obtained from a diverse range (2-72 years) of healthy donors...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28298929/%C3%AE-arrestin1-mir-326-transcription-unit-is-epigenetically-regulated-in-neural-stem-cells-where-it-controls-stemness-and-growth-arrest
#10
Agnese Po, Federica Begalli, Luana Abballe, Vincenzo Alfano, Zein Mersini Besharat, Giuseppina Catanzaro, Alessandra Vacca, Maddalena Napolitano, Marco Tafani, Felice Giangaspero, Franco Locatelli, Elisabetta Ferretti, Evelina Miele
Cell development is regulated by a complex network of mRNA-encoded proteins and microRNAs, all funnelling onto the modulation of self-renewal or differentiation genes. How intragenic microRNAs and their host genes are transcriptionally coregulated and their functional relationships for the control of neural stem cells (NSCs) are poorly understood. We propose here the intragenic miR-326 and its host gene β-arrestin1 as novel players whose epigenetic silencing maintains stemness in normal cerebellar stem cells...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28298928/biological-characteristics-of-fluorescent-superparamagnetic-iron-oxide-labeled-human-dental-pulp-stem-cells
#11
Liang Ma, Ming-Wei Li, Yu Bai, Hui-Hui Guo, Sheng-Chao Wang, Qing Yu
Tracking transplanted stem cells is necessary to clarify cellular properties and improve transplantation success. In this study, we investigate the effects of fluorescent superparamagnetic iron oxide particles (SPIO) (Molday ION Rhodamine-B™, MIRB) on biological properties of human dental pulp stem cells (hDPSCs) and monitor hDPSCs in vitro and in vivo using magnetic resonance imaging (MRI). Morphological analysis showed that intracellular MIRB particles were distributed in the cytoplasm surrounding the nuclei of hDPSCs...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28298927/therapeutic-potential-of-olfactory-ensheathing-cells-and-mesenchymal-stem-cells-in-spinal-cord-injuries
#12
REVIEW
Zadroga Anna, Jezierska-Woźniak Katarzyna, Czarzasta Joanna, Monika Barczewska, Wojtkiewicz Joanna, Maksymowicz Wojciech
Spinal cord injury (SCI) is a devastating neurological condition that affects individuals worldwide, significantly reducing quality of life, for both patients and their families. In recent years there has been a growing interest in cell therapy potential in the context of spinal cord injuries. The present review aims to discuss and compare the restorative approaches based on the current knowledge, available spinal cord restorative cell therapies, and use of selected cell types. However, treatment options for spinal cord injury are limited, but rehabilitation and experimental technologies have been found to help maintain or improve remaining nerve function in some cases...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28293262/transcriptome-profiling-of-il-17a-preactivated-mesenchymal-stem-cells-a-comparative-study-to-unmodified-and-ifn-%C3%AE-modified-mesenchymal-stem-cells
#13
Kisha Nandini Sivanathan, Darling Rojas-Canales, Shane T Grey, Stan Gronthos, Patrick T Coates
Human mesenchymal stem cells pretreatment with IL-17A (MSC-17) potently enhances T cell immunosuppression but not their immunogenicity, in addition to avidly promoting the induction of suppressive regulatory T cells. The aim of this study was to identify potential mechanisms by which human MSC-17 mediate their superior immunomodulatory function. Untreated-MSC (UT-MSC), IFN-γ treated MSC (MSC-γ), and MSC-17 were assessed for their gene expression profile by microarray. Significantly regulated genes were identified for their biological functions (Database for Annotation, Visualisation and Integrated Discovery, DAVID)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28286525/mesenchymal-stem-and-progenitor-cells-in-regeneration-tissue-specificity-and-regenerative-potential
#14
REVIEW
Rokhsareh Rohban, Thomas Rudolf Pieber
It has always been an ambitious goal in medicine to repair or replace morbid tissues for regaining the organ functionality. This challenge has recently gained momentum through considerable progress in understanding the biological concept of the regenerative potential of stem cells. Routine therapeutic procedures are about to shift towards the use of biological and molecular armamentarium. The potential use of embryonic stem cells and invention of induced pluripotent stem cells raised hope for clinical regenerative purposes; however, the use of these interventions for regenerative therapy showed its dark side, as many health concerns and ethical issues arose in terms of using these cells in clinical applications...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28286524/mesenchymal-stem-cells-for-the-treatment-of-spinal-arthrodesis-from-preclinical-research-to-clinical-scenario
#15
REVIEW
F Salamanna, M Sartori, G Barbanti Brodano, C Griffoni, L Martini, S Boriani, M Fini
The use of spinal fusion procedures has rapidly augmented over the last decades and although autogenous bone graft is the "gold standard" for these procedures, alternatives to its use have been investigated over many years. A number of emerging strategies as well as tissue engineering with mesenchymal stem cells (MSCs) have been planned to enhance spinal fusion rate. This descriptive systematic literature review summarizes the in vivo studies, dealing with the use of MSCs in spinal arthrodesis surgery and the state of the art in clinical applications...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28265289/evaluating-wharton-s-jelly-derived-mesenchymal-stem-cell-s-survival-migration-and-expression-of-wound-repair-markers-under-conditions-of-ischemia-like-stress
#16
Iris Himal, Umesh Goyal, Malancha Ta
The efficacy of mesenchymal stem cell (MSC) therapy is currently limited by low retention and poor survival of transplanted cells as demonstrated by clinical studies. This is mainly due to the harsh microenvironment created by oxygen and nutrient deprivation and inflammation at the injured sites. The choice of MSC source could be critical in determining fate and cellular function of MSCs under stress. Our objective here was to investigate the influence of ischemia-like stress on Wharton's jelly MSCs (WJ-MSCs) from human umbilical cord to assess their therapeutic relevance in ischemic diseases...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28265288/intravenous-administration-of-adipose-derived-stem-cell-protein-extracts-improves-neurological-deficits-in-a-rat-model-of-stroke
#17
Kai Zhao, Rui Li, Changcong Gu, Long Liu, Yulong Jia, Xize Guo, Wanping Zhang, Chunying Pei, Linlu Tian, Bo Li, Jianrong Jia, Huakun Cheng, Hongwei Xu, Lixian Li
Treatment of adipose-derived stem cell (ADSC) substantially improves the neurological deficits during stroke by reducing neuronal injury, limiting proinflammatory immune responses, and promoting neuronal repair, which makes ADSC-based therapy an attractive approach for treating stroke. However, the potential risk of tumorigenicity and low survival rate of the implanted cells limit the clinical use of ADSC. Cell-free extracts from ADSC (ADSC-E) may be a feasible approach that could overcome these limitations...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28261273/capacity-of-human-dental-follicle-cells-to-differentiate-into-neural-cells-in-vitro
#18
Shingo Kanao, Naomi Ogura, Kosuke Takahashi, Ko Ito, Masaaki Suemitsu, Kayo Kuyama, Toshirou Kondoh
The dental follicle is an ectomesenchymal tissue surrounding the developing tooth germ. Human dental follicle cells (hDFCs) have the capacity to commit to differentiation into multiple cell types. Here we investigated the capacity of hDFCs to differentiate into neural cells and the efficiency of a two-step strategy involving floating neurosphere-like bodies for neural differentiation. Undifferentiated hDFCs showed a spindle-like morphology and were positive for neural markers such as nestin, β-III-tubulin, and S100β...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28261272/stem-cells-in-cartilage-regeneration
#19
EDITORIAL
Jianying Zhang, Shiwu Dong, Wesley Sivak, Hui Bin Sun, Kai Tao
No abstract text is available yet for this article.
2017: Stem Cells International
https://www.readbyqxmd.com/read/28255307/overexpression-of-heme-oxygenase-1-in-mesenchymal-stem-cells-augments-their-protection-on-retinal-cells-in-vitro-and-attenuates-retinal-ischemia-reperfusion-injury-in-vivo-against-oxidative-stress
#20
Li Li, GaiPing Du, DaJiang Wang, Jin Zhou, Guomin Jiang, Hua Jiang
Retinal ischemia/reperfusion (I/R) injury, involving several ocular diseases, seriously threatens human ocular health, mainly treated by attenuating I/R-induced oxidative stress. Currently, mesenchymal stem cells (MSCs) could restore I/R-injured retina through paracrine secretion. Additionally, heme oxygenase-1 (HO-1) could ameliorate oxidative stress and thus retinal apoptosis, but the expression of HO-1 in MSC is limited. Here, we hypothesized that overexpression of HO-1 in MSC (MSC-HO-1) may significantly improve their retina-protective potentials...
2017: Stem Cells International
journal
journal
43149
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"